{
    "assessed_biomarker_entity": "Interferon gamma (IFNG)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "P01579-1",
                "name": "Interferon gamma",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "31986264",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/31986264"
                    },
                    {
                        "id": "15296648",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/15296648"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "monitoring",
            "status": "increased IFNG level",
            "notes": "Measured in serum (UN:0001977) and plasma (UN:0001969) as well.",
            "literature_evidence": "We noted that patients infected with 2019-nCoV also had high amounts of IL1B, IFN gamma, IP10, and MCP1, probably leading to activated T-helper-1 (Th1) cell responses. Initial plasma IL1B concentrations were higher in both ICU patients and non-ICU patients than in healthy adults. [PMID:31986264]",
            "loinc_code": "12729-0",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:0080600",
                "recommended_name": {
                    "id": "DOID:0080600",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080600",
                    "name": "COVID-19",
                    "description": "A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2."
                },
                "synonyms": [
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019 Novel Coronavirus (2019-nCoV)",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019-nCoV infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan coronavirus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan seafood market pneumonia virus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "COVID19",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "SARS-CoV-2 infection",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "31986264",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31986264"
                }
            ]
        },
        {
            "best_biomarker_type": "diagnostic",
            "status": "increased IFNG level",
            "notes": "",
            "literature_evidence": "IFN gamma level in patients from group 1 (T2DM) was 3.13 \u00b1 0.92 pg/ml, group 2 (CC) 2.73 \u00b1 0.91 pg/ ml, group 3 (T2DM and CC) 2.46 \u00b1 0.98 pg/ml and group 4 (control) 5.02 \u00b1 1.43 pg/ml; p < 0.05. There was no statistically significant difference in the concentration of IFN gamma in patients with T2DM and CC compared to other subjects. However, it has been demonstrated that level of IFN gamma in the control group and the group of patients with T2DM without CC was higher than in the other two groups. [PMID:15296648]",
            "loinc_code": "12729-0",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:9351",
                "recommended_name": {
                    "id": "DOID:9351",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9351",
                    "name": "diabetes mellitus",
                    "description": "A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both."
                },
                "synonyms": [
                    {
                        "id": "DOID:9351",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:9351",
                        "name": "diabetes",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "15296648",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/15296648"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Intracellular IFN-gamma production and IL-12 serum levels in latent autoimmune diabetes of adults (LADA) and in type 2 diabetes.",
            "journal": "Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research",
            "authors": "Tsiavou A, Degiannis D, Hatziagelaki E, Koniavitou K, Raptis SA",
            "date": "2004",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15296648",
                    "url": "https://glygen.org/publication/PubMed/15296648"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        },
        {
            "title": "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.",
            "journal": "Lancet (London, England)",
            "authors": "Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31986264",
                    "url": "https://glygen.org/publication/PubMed/31986264"
                }
            ],
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                    "id": "GLY_000625",
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                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
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            "id": "31986264",
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        },
        {
            "id": "15296648",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/15296648"
        }
    ],
    "biomarker_id": "A0041",
    "aclist": [
        "P01579-1"
    ],
    "crossref": [],
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