{ "assessed_biomarker_entity": "Cardiac troponin (TNN)", "assessed_entity_type": "protein", "components": { "protein": [ { "accession": "Q6P1J9-1", "name": "Parafibromin", "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "32702736", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32702736" }, { "id": "32475810", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32475810" }, { "id": "32416124", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32416124" }, { "id": "22120679", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22120679" } ] } ], "glycan": [] }, "instances": [ { "best_biomarker_type": "prognostic", "status": "increased TNN level", "notes": "", "literature_evidence": "Cardiac biomarkers add prognostic value to the determination of the severity of COVID-19 and can predict mortality. [PMID:32702736] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] These results are of prognostic importance, since patients with elevated troponins have higher risk of in-hospital mortality, are more prone to deterioration during hospital stay and so deserve more focused clinical attention. [PMID:32416124]", "loinc_code": "89575-5", "tissue": { "name": "blood", "namespace": "UBERON", "id": "0000178", "url": "http://purl.obolibrary.org/obo/UBERON_0000178" }, "disease": { "disease_id": "DOID:0080600", "recommended_name": { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "COVID-19", "description": "A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2." }, "synonyms": [ { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "2019 Novel Coronavirus (2019-nCoV)", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "2019-nCoV infection", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "Wuhan coronavirus infection", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "Wuhan seafood market pneumonia virus infection", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "COVID19", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "SARS-CoV-2 infection", "description": "" } ] }, "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "32702736", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32702736" }, { "id": "32475810", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32475810" }, { "id": "32416124", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32416124" } ] }, { "best_biomarker_type": "monitoring", "status": "increased TNN level", "notes": "", "literature_evidence": "The prevalence and determinant of chronic cTnT elevation was studied in a large, representative population consisting of 3557 subjects of the Dallas Heart Study. cTnT elevation was associated with older age, black race, male sex, congestive heart failure, left ventricular hypertrophy, diabetes mellitus, and chronic kidney disease. In the general population, cTnT elevation is a rare in subjects without congestive heart failure, left ventricular hypertrophy, chronic kidney disease, or diabetes mellitus. Studies have shown that Tn release in heart failure (HF) occurs with and without obstructive epicardial coronary disease. [PMID:22120679]", "loinc_code": "89575-5", "tissue": { "name": "blood", "namespace": "UBERON", "id": "0000178", "url": "http://purl.obolibrary.org/obo/UBERON_0000178" }, "disease": { "disease_id": "DOID:9351", "recommended_name": { "id": "DOID:9351", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9351", "name": "diabetes mellitus", "description": "A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both." }, "synonyms": [ { "id": "DOID:9351", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9351", "name": "diabetes", "description": "" } ] }, "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "22120679", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22120679" } ] } ], "publication": [ { "title": "A review of causes and systemic approach to cardiac troponin elevation.", "journal": "Clinical cardiology", "authors": "Patil Harshal, Vaidya Omkar, Bogart Douglas", "date": "2011-12", "reference": [ { "type": "PubMed", "id": "22120679", "url": "https://glygen.org/publication/PubMed/22120679" } ], "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" } ] }, { "title": "The role of biomarkers in diagnosis of COVID-19 - A systematic review.", "journal": "Life sciences", "authors": "Kermali M, Khalsa RK, Pillai K, Ismail Z, Harky A", "date": "2020", "reference": [ { "type": "PubMed", "id": "32475810", "url": "https://glygen.org/publication/PubMed/32475810" } ], "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" } ] }, { "title": "Prognostic value of Cardiac Biomarkers in COVID-19 Infection: A Meta-analysis.", "journal": "Research square", "authors": "Dawson Desiree, Dominic Paari, Sheth Aakash, Modi Malak", "date": "2020-06-13", "reference": [ { "type": "PubMed", "id": "32702736", "url": "https://glygen.org/publication/PubMed/32702736" } ], "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" } ] }, { "title": "Cardiac troponins predict mortality in patients with COVID-19: A meta-analysis of adjusted risk estimates.", "journal": "The Journal of infection", "authors": "Vrsalovic Mislav, Vrsalovic Presecki Ana", "date": "2020-09", "reference": [ { "type": "PubMed", "id": "32416124", "url": "https://glygen.org/publication/PubMed/32416124" } ], "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" } ] } ], "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "32702736", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32702736" }, { "id": "32475810", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32475810" }, { "id": "32416124", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32416124" }, { "id": "22120679", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22120679" } ], "biomarker_id": "A0029", "aclist": [ "Q6P1J9-1" ], "crossref": [], "section_stats": [ { "table_id": "instances", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "best_biomarker_type", "status", "notes", "literature_evidence", "loinc_code", "tissue.name", "tissue.namespace", "tissue.id", "tissue.url", "disease.disease_id" ] }, { "table_id": "components", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "authors", "date" ] } ] }