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            "notes": "",
            "literature_evidence": "Together with the reported markers of liver injury, such hyperinflammatory state may trigger significant derangements in hepatic cytochrome P450 metabolic machinery, and subsequent modulation of drug clearance that may result in unexpected therapeutic/toxic response. We hypothesize that COVID-19 patients are potentially vulnerable to a significant disease-drug interaction, and therefore, suitable dosing guidelines with therapeutic drug monitoring should be implemented to assure optimal clinical outcomes. [PMID:32758877]",
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                        "id": "DOID:3571",
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                        "description": ""
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                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
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                        "id": "DOID:3571",
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                        "id": "DOID:3571",
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                        "id": "DOID:3571",
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                        "id": "DOID:3571",
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                        "description": ""
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                    {
                        "id": "DOID:3571",
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                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
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                        "description": ""
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            "title": "Cytochrome P450-mediated drug interactions in COVID-19 patients: Current findings and possible mechanisms.",
            "journal": "Medical hypotheses",
            "authors": "El-Ghiaty MA, Shoieb SM, El-Kadi AOS",
            "date": "2020",
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        {
            "title": "CYP3A4 Gene Is a Novel Biomarker for Predicting a Poor Prognosis in Hepatocellular Carcinoma.",
            "journal": "Cancer genomics & proteomics",
            "authors": "Ashida R, Okamura Y, Ohshima K, Kakuda Y, Uesaka K, Sugiura T, Ito T, Yamamoto Y, Sugino T, Urakami K, Kusuhara M, Yamaguchi K",
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