[ { "uniprot_canonical_ac": "Q9Y6V0-5", "uniprot_ac": "Q9Y6V0", "uniprot_id": "PCLO_HUMAN", "mass": { "chemical_mass": 560699.0, "monoisotopic_mass": 560699.0 }, "refseq": { "ac": "NP_055325", "name": "protein piccolo isoform 2", "summary": "The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055325" }, "gene_names": [ { "name": "PCLO", "type": "recommended", "evidence": [ { "id": "Q9Y6V0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ] }, { "name": "ACZ", "type": "synonym", "evidence": [ { "id": "NP_055325", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055325" }, { "id": "Q9Y6V0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ] }, { "name": "KIAA0559", "type": "synonym", "evidence": [ { "id": "Q9Y6V0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ] }, { "name": "PCH3", "type": "synonym", "evidence": [ { "id": "NP_055325", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055325" } ] }, { "name": "PCLO", "type": "synonym", "evidence": [ { "id": "NP_055325", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055325" } ] } ], "protein_names": [ { "name": "Protein piccolo", "type": "recommended", "evidence": [ { "id": "Q9Y6V0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0/entry#names_and_taxonomy" } ] }, { "name": "Aczonin", "type": "synonym", "evidence": [ { "id": "Q9Y6V0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0/entry#names_and_taxonomy" } ] }, { "name": "aczonin", "type": "synonym", "evidence": [ { "id": "NP_055325", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055325" } ] }, { "name": "protein piccolo isoform 2", "type": "synonym", "evidence": [ { "id": "NP_055325", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055325" } ] }, { "name": "protein piccolo", "type": "synonym", "evidence": [ { "id": "NP_055325", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055325" } ] } ], "function": [ { "annotation": "In an analysis comparing 1,942 cases with lifetime diagnosis of MDD and 4,565 controls, PCLO showed a genome-wide significant association with major depressive disorder at SNP (rs2715157, p = 2.91 x 10-8) and gene-based (p = 1.48 x 10-7) level.", "evidence": [ { "database": "RefSeq", "id": "NP_055325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055325" }, { "database": "PubMed", "id": "28540843", "url": "https://glygen.org/publication/PubMed/28540843" } ] }, { "annotation": "No symphony without bassoon and piccolo: changes in synaptic active zone proteins in Huntington's disease. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_055325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055325" }, { "database": "PubMed", "id": "32493491", "url": "https://glygen.org/publication/PubMed/32493491" } ] }, { "annotation": "Piccolo contributes to tumor aggressiveness in esophageal squamous cell carcinoma, likely by stabilizing EGFR and promoting EGFR-dependent signaling.", "evidence": [ { "database": "RefSeq", "id": "NP_055325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055325" }, { "database": "PubMed", "id": "28263981", "url": "https://glygen.org/publication/PubMed/28263981" } ] }, { "annotation": "Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (By similarity). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0#function" }, { "database": "UniProtKB", "id": "Q9JKS6", "url": "https://www.uniprot.org/uniprotkb/Q9JKS6#function" } ] }, { "annotation": "The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].", "evidence": [ { "database": "RefSeq", "id": "NP_055325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055325" } ] } ], "disease": [ { "disease_id": "DOID:0060272", "recommended_name": { "id": "DOID:0060272", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0060272", "name": "pontocerebellar hypoplasia type 3", "description": "A pontocerebellar hypoplasia that is characterized by progressive microcephaly, hypotonia, dysmorphic features, profound intellectual disability and seizure, has_material_basis_in autosomal recessive inheritance of mutation in the PCLO gene." }, "synonyms": [ { "id": "MONDO:0011948", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011948", "name": "pontocerebellar hypoplasia type 3", "description": "Pontocerebellar hypoplasia type 3 (PCH3), also known as cerebellar atrophy with progressive microcephaly (CLAM) is a rare form of pontocerebellar hypoplasia with autosomal recessive transmission characterized neonatally by hypotonia and impaired swallowing and from infancy onward by seizures, optic atrophy and short stature, but none of the clinical findings are specific for PCH3." }, { "id": "MONDO:0011948", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011948", "name": "PCH with optic atrophy", "description": "" }, { "id": "MONDO:0011948", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011948", "name": "PCH without dyskinesia", "description": "" }, { "id": "MONDO:0011948", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011948", "name": "PCH3", "description": "" }, { "id": "MONDO:0011948", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011948", "name": "PCLO non-syndromic pontocerebellar hypoplasia", "description": "" }, { "id": "MONDO:0011948", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011948", "name": "cerebellar atrophy with progressive microcephaly", "description": "" }, { "id": "MONDO:0011948", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011948", "name": "clam", "description": "" }, { "id": "MONDO:0011948", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011948", "name": "non-syndromic pontocerebellar hypoplasia caused by mutation in PCLO", "description": "" }, { "id": "MONDO:0011948", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011948", "name": "pontocerebellar hypoplasia, type 3", "description": "" }, { "id": "MIM:608027", "resource": "MIM", "url": "https://www.omim.org/entry/608027", "name": "Pontocerebellar hypoplasia 3", "description": "Pontocerebellar hypoplasia 3" } ], "unlinked_id_list": [], "evidence": [ { "id": "608027", "database": "MIM", "url": "https://www.omim.org/entry/608027" }, { "id": "0060272", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060272" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "74.43", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000186472", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186472" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "44.33", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000186472", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186472" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "64.3", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000186472", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186472" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "49.96", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000186472", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186472" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "62.32", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000186472", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186472" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "71.63", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000186472", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186472" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "47.76", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000186472", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186472" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "60.66", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000186472", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186472" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "76.24", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000186472", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186472" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "47.6", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000186472", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186472" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "55.48", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000186472", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186472" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "72.92", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000186472", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186472" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "68.16", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000186472", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186472" } ] } ], "expression_disease": [ { "significant": "No", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "Q9Y6V0", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9Y6V0" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] } ] }, { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "Q9Y6V0", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9Y6V0" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] } ] }, { "significant": "No", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "Q9Y6V0", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9Y6V0" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "11054", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ] } ] }, { "significant": "No", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "Q9Y6V0", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9Y6V0" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ], "unlinked_id_list": [ "DOID:1542" ], "evidence": [ { "id": "11934", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11934" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "Q9Y6V0", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9Y6V0" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" 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"https://www.iedb.org/epitope/2058818", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2063848", "url": "https://www.iedb.org/epitope/2063848", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2139732", "url": "https://www.iedb.org/epitope/2139732", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2140623", "url": "https://www.iedb.org/epitope/2140623", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2247648", "url": "https://www.iedb.org/epitope/2247648", "database": "IEDB", "categories": [ "Other" ] }, { "id": "542267", "url": "https://www.iedb.org/epitope/542267", "database": "IEDB", "categories": [ "Other" ] }, { "id": "543033", "url": "https://www.iedb.org/epitope/543033", "database": "IEDB", "categories": [ "Other" ] }, { "id": "546633", "url": "https://www.iedb.org/epitope/546633", "database": "IEDB", "categories": [ "Other" ] }, { "id": "565417", "url": "https://www.iedb.org/epitope/565417", "database": "IEDB", "categories": [ "Other" ] }, { "id": "876231", "url": "https://www.iedb.org/epitope/876231", "database": "IEDB", "categories": [ "Other" ] }, { "id": "930904", "url": "https://www.iedb.org/epitope/930904", "database": "IEDB", "categories": [ "Other" ] }, { "id": "950583", "url": "https://www.iedb.org/epitope/950583", "database": "IEDB", "categories": [ "Other" ] }, { "id": "951276", "url": "https://www.iedb.org/epitope/951276", "database": "IEDB", "categories": [ "Other" ] }, { "id": "992769", "url": "https://www.iedb.org/epitope/992769", "database": "IEDB", "categories": [ "Other" ] }, { "id": "Q9Y6V0", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9Y6V0*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042720", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042720", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:27445", "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:27445", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "604918", "url": "http://www.omim.org/entry/604918", "database": "MIM", "categories": [ "Other" ] }, { "id": "608027", "url": "http://www.omim.org/entry/608027", "database": "MIM", "categories": [ "Other" ] }, { "id": "Q9Y6V0", "url": "https://oglcnac.org/atlas/detail/Q9Y6V0", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "KVTTDHK", "url": "https://omabrowser.org/oma/group/KVTTDHK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q9Y6V0", "url": "https://www.orthodb.org/?gene=Q9Y6V0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14113", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14113", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14113:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14113:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00001ujd", "url": "https://www.rcsb.org/structure/pdb_00001ujd", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1UJD", "url": "https://www.rcsb.org/structure/1UJD", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF05715", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05715", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "Q9Y6V0", "url": "https://pharos.nih.gov/targets/Q9Y6V0", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR:Q9Y6V0", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:Q9Y6V0", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-9662360", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9662360", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_055325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055325", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9Y6V0-3", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9Y6V0-5", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0-5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9Y6V0-6", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0-6", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNEASLEGEGLPEGLAAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVPPAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQKALKSAEEMYEEMMHKTHKYKAFPAANERDEVFEKEPLYGGMLIEDYIYESLVEDTYNGSVDGSLLTRQEEENGFMQQKGREQKIRLSEQIYEDPMQKITDLQKEFYELESLHSVVPQEDIVSSSFIIPESHEIVDLGTMVTSTEEERKLLDADAAYEELMKRQQMQLTPGSSPTQAPIGEDMTESTMDFDRMPDASLTSSVLSGASLTDSTSSATLSIPDVKITQHFSTEEIEDEYVTDYTREIQEIIAHESLILTYSEPSESATSVPPSDTPSLTSSVSSVCTTDSSSPITTLDSITTVYTEPVDMITKFEDSEEISSSTYFPGSIIDYPEEISVSLDRTAPPDGRASADHIVISLSDMASSIIESVVPKPEGPVADTVSTDLLISEKDPVKKAKKETGNGIILEVLEAYRDKKELEAERTKSSLSETVFDHPPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPTDSSASQAITSWPLGSPSKDLVSVEPVFSVVPPVTAVEIPISSEQTFYISGALQTFSATPVTAPSSFQAAPTSVTQFLTTEVSKTEVSATRSTAPSVGLSSISITIPPEPLALDNIHLEKPQYKEDGKLQLVGDVIDLRTVPKVEVKTTDKCIDLSASTMDVKRQITANEVYGKQISAVQPSIINLSVTSSIVTPVSLATETVTFVTCTASASYTTGTESLVGAEHAMTTPLQLTTSKHAEPPYRIPSDQVFPIAREEAPINLSLGTPAHAVTLAITKPVTVPPVGVTNGWTDSTVSQGITDGEVVDLSTTKSHRTVVTMDESTSSVMTKIIEDEKPVDLTAGRRAVCCDVVYKLPFGRSCTAQQPATTLPEDRFGYRDDHYQYDRSGPYGYRGIGGMKPSMSDTNLAEAGHFFYKSKNAFDYSEGTDTAVDLTSGRVTTGEVMDYSSKTTGPYPETRQVISGAGISTPQYSTARMTPPPGPQYCVGSVLRSSNGVVYSSVATPTPSTFAITTQPGSIFSTTVRDLSGIHTADAVTSLPAMHHSQPMPRSYFITTGASETDIAVTGIDISASLQTITMESLTAETIDSVPTLTTASEVFPEVVGDESALLIVPEEDKQQQQLDLERELLELEKIKQQRFAEELEWERQEIQRFREQEKIMVQKKLEELQSMKQHLLFQQEEERQAQFMMRQETLAQQQLQLEQIQQLQQQLHQQLEEQKIRQIYQYNYDPSGTASPQTTTEQAILEGQYAALEGSQFWATEDATTTASAVVAIEIPQSQGWYTVQSDGVTQYIAPPGILSTVSEIPLTDVVVKEEKQPKKRSSGAKVRGQYDDMGENMTDDPRSFKKIVDSGVQTDDEDATDRSYVSRRRRTKKSVDTSVQTDDEDQDEWDMPTRSRRKARVGKYGDSMTEADKTKPLSKVSSIAVQTVAEISVQTEPVGTIRTPSIRARVDAKVEIIKHISAPEKTYKGGSLGCQTEADSDTQSPQYLSATSPPKDKKRPTPLEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRAPFQYTEGYTTKGSQTMTSSGAQKKVKRTLPNPPPEEISTGTQSTFSTMGTVSRRRICRTNTMARAKILQDIDRELDLVERESAKLRKKQAELDEEEKEIDAKLRYLEMGINRRKEALLKEREKRERAYLQGVAEDRDYMSDSEVSSTRPTRIESQHGIERPRTAPQTEFSQFIPPQTQTESQLVPPTSPYTQYQYSSPALPTQAPTSYTQQSHFEQQTLYHQQVSPYQTQPTFQAVATMSFTPQVQPTPTPQPSYQLPSQMMVIQQKPRQTTLYLEPKITSNYEVIRNQPLMIAPVSTDNTFAVSHLGSKYNSLDLRIGLEERSSMASSPISSISADSFYADIDHHTPRNYVLIDDIGEITKGTAALSTAFSLHEKDLSKTDRLLRTTETRRSQEVTDFLAPLQSSSRLHSYVKAEEDPMEDPYELKLLKHQIKQEFRRGTESLDHLAGLSHYYHADTSYRHFPKSEKYSISRLTLEKQAAKQLPAAILYQKQSKHKKSLIDPKMSKFSPIQESRDLEPDYSSYMTSSTSSIGGISSRARLLQDDITFGLRKNITDQQKFMGSSLGTGLGTLGNTIRSALQDEADKPYSSGSRSRPSSRPSSVYGLDLSIKRDSSSSSLRLKAQEAEALDVSFSHASSSARTKPTSLPISQSRGRIPIVAQNSEEESPLSPVGQPMGMARAAAGPLPPISADTRDQFGSSHSLPEVQQHMREESRTRGYDRDIAFIMDDFQHAMSDSEAYHLRREETDWFDKPRESRLENGHGLDRKLPERLVHSRPLSQHQEQIIQMNGKTMHYIFPHARIKITRDSKDHTVSGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGGSAEQTGKLMEGMQVLEWNGIPLTSKTYEEVQSIISQQSGEAEICVRLDLNMLSDSENSQHLELHEPPKAVDKAKSPGVDPKQLAAELQKVSLQQSPLVLSSVVEKGSHVHSGPTSAGSSSVPSPGQPGSPSVSKKKHGSSKPTDGTKVVSHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSNDFLGEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKSHSSQSSQQSPKPSVIKSRSHGIFPDPSKDMQVPTIEKSHSSPGSSKSSSEGHLRSHGPSRSQSKTSVTQTHLEDAGAAIAAAEAAVQQLRIQPTKPPNHRPAESSVSTGSSGSSFGSGYSVDSEGSSSTAGETNLFPIPRIGKMGQNGQEPVKQPGVGVGLADTEAKTQVMGEIKIALKKEMKTDGEQLIVEILQCRNITYKFKSPDHLPDLYVKIYVMNISTQKKVIKKKTRVCRHDREPSFNETFRFSLSPAGHSLQILLFSNGGKFMKKTLIGEACIWLDKVDLRKRIVNWHKLLVSPTQTH", "length": 5142, "header": "sp|Q9Y6V0-5|PCLO_HUMAN Isoform 5 of Protein piccolo OS=Homo sapiens OX=9606 GN=PCLO PE=1 SV=5 CANONICAL=Q9Y6V0-5" }, "isoforms": [ { "isoform_ac": "Q9Y6V0-3", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0/entry#Q9Y6V0-3", "sequence": { "sequence": "MKKFRVSLVSKVGKQKYVDLNMLSDSENSQHLELHEPPKAVDKAKSPGVDPKQLAAELQKVSLQQSPLVLSSVVEKGSHVHSGPTSAGSSSVPSPGQPGSPSVSKKKHGSSKPTDGTKVVSHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSNDFLGEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKSHSSQSSQQSPKPSVIKSRSHGIFPDPSKDMQVPTIEKSHSSPGSSKSSSEGHLRSHGPSRSQSKTSVTQTHLEDAGAAIAAAEAAVQQLRIQPSKRRK", "length": 356, "header": "sp|Q9Y6V0-3|PCLO_HUMAN Isoform 3 of Protein piccolo OS=Homo sapiens OX=9606 GN=PCLO PE=1 SV=5 CANONICAL=Q9Y6V0-5" }, "locus": {} }, { "isoform_ac": "Q9Y6V0-5", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0/entry#Q9Y6V0-5", "sequence": { "sequence": "MGNEASLEGEGLPEGLAAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVPPAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQKALKSAEEMYEEMMHKTHKYKAFPAANERDEVFEKEPLYGGMLIEDYIYESLVEDTYNGSVDGSLLTRQEEENGFMQQKGREQKIRLSEQIYEDPMQKITDLQKEFYELESLHSVVPQEDIVSSSFIIPESHEIVDLGTMVTSTEEERKLLDADAAYEELMKRQQMQLTPGSSPTQAPIGEDMTESTMDFDRMPDASLTSSVLSGASLTDSTSSATLSIPDVKITQHFSTEEIEDEYVTDYTREIQEIIAHESLILTYSEPSESATSVPPSDTPSLTSSVSSVCTTDSSSPITTLDSITTVYTEPVDMITKFEDSEEISSSTYFPGSIIDYPEEISVSLDRTAPPDGRASADHIVISLSDMASSIIESVVPKPEGPVADTVSTDLLISEKDPVKKAKKETGNGIILEVLEAYRDKKELEAERTKSSLSETVFDHPPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPTDSSASQAITSWPLGSPSKDLVSVEPVFSVVPPVTAVEIPISSEQTFYISGALQTFSATPVTAPSSFQAAPTSVTQFLTTEVSKTEVSATRSTAPSVGLSSISITIPPEPLALDNIHLEKPQYKEDGKLQLVGDVIDLRTVPKVEVKTTDKCIDLSASTMDVKRQITANEVYGKQISAVQPSIINLSVTSSIVTPVSLATETVTFVTCTASASYTTGTESLVGAEHAMTTPLQLTTSKHAEPPYRIPSDQVFPIAREEAPINLSLGTPAHAVTLAITKPVTVPPVGVTNGWTDSTVSQGITDGEVVDLSTTKSHRTVVTMDESTSSVMTKIIEDEKPVDLTAGRRAVCCDVVYKLPFGRSCTAQQPATTLPEDRFGYRDDHYQYDRSGPYGYRGIGGMKPSMSDTNLAEAGHFFYKSKNAFDYSEGTDTAVDLTSGRVTTGEVMDYSSKTTGPYPETRQVISGAGISTPQYSTARMTPPPGPQYCVGSVLRSSNGVVYSSVATPTPSTFAITTQPGSIFSTTVRDLSGIHTADAVTSLPAMHHSQPMPRSYFITTGASETDIAVTGIDISASLQTITMESLTAETIDSVPTLTTASEVFPEVVGDESALLIVPEEDKQQQQLDLERELLELEKIKQQRFAEELEWERQEIQRFREQEKIMVQKKLEELQSMKQHLLFQQEEERQAQFMMRQETLAQQQLQLEQIQQLQQQLHQQLEEQKIRQIYQYNYDPSGTASPQTTTEQAILEGQYAALEGSQFWATEDATTTASAVVAIEIPQSQGWYTVQSDGVTQYIAPPGILSTVSEIPLTDVVVKEEKQPKKRSSGAKVRGQYDDMGENMTDDPRSFKKIVDSGVQTDDEDATDRSYVSRRRRTKKSVDTSVQTDDEDQDEWDMPTRSRRKARVGKYGDSMTEADKTKPLSKVSSIAVQTVAEISVQTEPVGTIRTPSIRARVDAKVEIIKHISAPEKTYKGGSLGCQTEADSDTQSPQYLSATSPPKDKKRPTPLEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRAPFQYTEGYTTKGSQTMTSSGAQKKVKRTLPNPPPEEISTGTQSTFSTMGTVSRRRICRTNTMARAKILQDIDRELDLVERESAKLRKKQAELDEEEKEIDAKLRYLEMGINRRKEALLKEREKRERAYLQGVAEDRDYMSDSEVSSTRPTRIESQHGIERPRTAPQTEFSQFIPPQTQTESQLVPPTSPYTQYQYSSPALPTQAPTSYTQQSHFEQQTLYHQQVSPYQTQPTFQAVATMSFTPQVQPTPTPQPSYQLPSQMMVIQQKPRQTTLYLEPKITSNYEVIRNQPLMIAPVSTDNTFAVSHLGSKYNSLDLRIGLEERSSMASSPISSISADSFYADIDHHTPRNYVLIDDIGEITKGTAALSTAFSLHEKDLSKTDRLLRTTETRRSQEVTDFLAPLQSSSRLHSYVKAEEDPMEDPYELKLLKHQIKQEFRRGTESLDHLAGLSHYYHADTSYRHFPKSEKYSISRLTLEKQAAKQLPAAILYQKQSKHKKSLIDPKMSKFSPIQESRDLEPDYSSYMTSSTSSIGGISSRARLLQDDITFGLRKNITDQQKFMGSSLGTGLGTLGNTIRSALQDEADKPYSSGSRSRPSSRPSSVYGLDLSIKRDSSSSSLRLKAQEAEALDVSFSHASSSARTKPTSLPISQSRGRIPIVAQNSEEESPLSPVGQPMGMARAAAGPLPPISADTRDQFGSSHSLPEVQQHMREESRTRGYDRDIAFIMDDFQHAMSDSEAYHLRREETDWFDKPRESRLENGHGLDRKLPERLVHSRPLSQHQEQIIQMNGKTMHYIFPHARIKITRDSKDHTVSGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGGSAEQTGKLMEGMQVLEWNGIPLTSKTYEEVQSIISQQSGEAEICVRLDLNMLSDSENSQHLELHEPPKAVDKAKSPGVDPKQLAAELQKVSLQQSPLVLSSVVEKGSHVHSGPTSAGSSSVPSPGQPGSPSVSKKKHGSSKPTDGTKVVSHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSNDFLGEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKSHSSQSSQQSPKPSVIKSRSHGIFPDPSKDMQVPTIEKSHSSPGSSKSSSEGHLRSHGPSRSQSKTSVTQTHLEDAGAAIAAAEAAVQQLRIQPTKPPNHRPAESSVSTGSSGSSFGSGYSVDSEGSSSTAGETNLFPIPRIGKMGQNGQEPVKQPGVGVGLADTEAKTQVMGEIKIALKKEMKTDGEQLIVEILQCRNITYKFKSPDHLPDLYVKIYVMNISTQKKVIKKKTRVCRHDREPSFNETFRFSLSPAGHSLQILLFSNGGKFMKKTLIGEACIWLDKVDLRKRIVNWHKLLVSPTQTH", "length": 5142, "header": "sp|Q9Y6V0-5|PCLO_HUMAN Isoform 5 of Protein piccolo OS=Homo sapiens OX=9606 GN=PCLO PE=1 SV=5 CANONICAL=Q9Y6V0-5" }, "locus": { "chromosome": "7", "start_pos": 83162592, "end_pos": 82758578, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000333891.14", "url": "https://www.ensembl.org/id/ENST00000333891.14" }, { "database": "Ensembl Peptide", "id": "ENSP00000334319.8", "url": "https://www.ensembl.org/id/ENSP00000334319.8" } ] } }, { "isoform_ac": "Q9Y6V0-6", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0/entry#Q9Y6V0-6", "sequence": { "sequence": "MGNEASLEGEGLPEGLAAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVPPAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQKALKSAEEMYEEMMHKTHKYKAFPAANERDEVFEKEPLYGGMLIEDYIYESLVEDTYNGSVDGSLLTRQEEENGFMQQKGREQKIRLSEQIYEDPMQKITDLQKEFYELESLHSVVPQEDIVSSSFIIPESHEIVDLGTMVTSTEEERKLLDADAAYEELMKRQQMQLTPGSSPTQAPIGEDMTESTMDFDRMPDASLTSSVLSGASLTDSTSSATLSIPDVKITQHFSTEEIEDEYVTDYTREIQEIIAHESLILTYSEPSESATSVPPSDTPSLTSSVSSVCTTDSSSPITTLDSITTVYTEPVDMITKFEDSEEISSSTYFPGSIIDYPEEISVSLDRTAPPDGRASADHIVISLSDMASSIIESVVPKPEGPVADTVSTDLLISEKDPVKKAKKETGNGIILEVLEAYRDKKELEAERTKSSLSETVFDHPPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPTDSSASQAITSWPLGSPSKDLVSVEPVFSVVPPVTAVEIPISSEQTFYISGALQTFSATPVTAPSSFQAAPTSVTQFLTTEVSKTEVSATRSTAPSVGLSSISITIPPEPLALDNIHLEKPQYKEDGKLQLVGDVIDLRTVPKVEVKTTDKCIDLSASTMDVKRQITANEVYGKQISAVQPSIINLSVTSSIVTPVSLATETVTFVTCTASASYTTGTESLVGAEHAMTTPLQLTTSKHAEPPYRIPSDQVFPIAREEAPINLSLGTPAHAVTLAITKPVTVPPVGVTNGWTDSTVSQGITDGEVVDLSTTKSHRTVVTMDESTSSVMTKIIEDEKPVDLTAGRRAVCCDVVYKLPFGRSCTAQQPATTLPEDRFGYRDDHYQYDRSGPYGYRGIGGMKPSMSDTNLAEAGHFFYKSKNAFDYSEGTDTAVDLTSGRVTTGEVMDYSSKTTGPYPETRQVISGAGISTPQYSTARMTPPPGPQYCVGSVLRSSNGVVYSSVATPTPSTFAITTQPGSIFSTTVRDLSGIHTADAVTSLPAMHHSQPMPRSYFITTGASETDIAVTGIDISASLQTITMESLTAETIDSVPTLTTASEVFPEVVGDESALLIVPEEDKQQQQLDLERELLELEKIKQQRFAEELEWERQEIQRFREQEKIMVQKKLEELQSMKQHLLFQQEEERQAQFMMRQETLAQQQLQLEQIQQLQQQLHQQLEEQKIRQIYQYNYDPSGTASPQTTTEQAILEGQYAALEGSQFWATEDATTTASAVVAIEIPQSQGWYTVQSDGVTQYIAPPGILSTVSEIPLTDVVVKEEKQPKKRSSGAKVRGQYDDMGENMTDDPRSFKKIVDSGVQTDDEDATDRSYVSRRRRTKKSVDTSVQTDDEDQDEWDMPTRSRRKARVGKYGDSMTEADKTKPLSKVSSIAVQTVAEISVQTEPVGTIRTPSIRARVDAKVEIIKHISAPEKTYKGGSLGCQTEADSDTQSPQYLSATSPPKDKKRPTPLEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRAPFQYTEGYTTKGSQTMTSSGAQKKVKRTLPNPPPEEISTGTQSTFSTMGTVSRRRICRTNTMARAKILQDIDRELDLVERESAKLRKKQAELDEEEKEIDAKLRYLEMGINRRKEALLKEREKRERAYLQGVAEDRDYMSDSEVSSTRPTRIESQHGIERPRTAPQTEFSQFIPPQTQTESQLVPPTSPYTQYQYSSPALPTQAPTSYTQQSHFEQQTLYHQQVSPYQTQPTFQAVATMSFTPQVQPTPTPQPSYQLPSQMMVIQQKPRQTTLYLEPKITSNYEVIRNQPLMIAPVSTDNTFAVSHLGSKYNSLDLRIGLEERSSMASSPISSISADSFYADIDHHTPRNYVLIDDIGEITKGTAALSTAFSLHEKDLSKTDRLLRTTETRRSQEVTDFLAPLQSSSRLHSYVKAEEDPMEDPYELKLLKHQIKQEFRRGTESLDHLAGLSHYYHADTSYRHFPKSEKYSISRLTLEKQAAKQLPAAILYQKQSKHKKSLIDPKMSKFSPIQESRDLEPDYSSYMTSSTSSIGGISSRARLLQDDITFGLRKNITDQQKFMGSSLGTGLGTLGNTIRSALQDEADKPYSSGSRSRPSSRPSSVYGLDLSIKRDSSSSSLRLKAQEAEALDVSFSHASSSARTKPTSLPISQSRGRIPIVAQNSEEESPLSPVGQPMGMARAAAGPLPPISADTRDQFGSSHSLPEVQQHMREESRTRGYDRDIAFIMDDFQHAMSDSEAYHLRREETDWFDKPRESRLENGHGLDRKLPERLVHSRPLSQHQEQIIQMNGKTMHYIFPHARIKITRDSKDHTVSGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGGSAEQTGKLMEGMQVLEWNGIPLTSKTYEEVQSIISQQSGEAEICVRLDLNMLSDSENSQHLELHEPPKAVDKAKSPGVDPKQLAAELQKVSLQQSPLVLSSVVEKGSHVHSGPTSAGSSSVPSPGQPGSPSVSKKKHGSSKPTDGTKVVSHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSNDFLGEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKSHSSQSSQQSPKPSVIKSRSHGIFPDPSKDMQVPTIEKSHSSPGSSKSSSEGHLRSHGPSRSQSKTSVTQTHLEDAGAAIAAAEAAVQQLRIQPSKRRK", "length": 4935, "header": "sp|Q9Y6V0-6|PCLO_HUMAN Isoform 6 of Protein piccolo OS=Homo sapiens OX=9606 GN=PCLO PE=1 SV=5 CANONICAL=Q9Y6V0-5" }, "locus": { "chromosome": "7", "start_pos": 83162592, "end_pos": 82822481, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000423517.6", "url": "https://www.ensembl.org/id/ENST00000423517.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000388393.2", "url": "https://www.ensembl.org/id/ENSP00000388393.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_pos": 2382, "start_aa": "Ser", "end_pos": 2382, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser2382", "evidence": [ { "id": "20563614", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/20563614" }, { "id": "Q9Y6V0", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9Y6V0" }, { "id": "28657654", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28657654" }, { "id": "28411811", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28411811" }, { "id": "29485866", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29485866" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "41350704", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/41350704" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "40136647", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40136647" } ], "filter_code": 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Cell Biol.", "date": "1999", "authors": "Wang X, Kibschull M, Laue M M, Lichte B, Petrasch-Parwez E, Kilimann M W", "evidence": [ { "database": "UniProtKB", "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ], "reference": [ { "type": "PubMed", "id": "10508862", "url": "https://glygen.org/publication/PubMed/10508862" } ] }, { "title": "RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function.", "journal": "Neuron", "date": "2000", "authors": "Schmitz F, Konigstorfer A, Sudhof TC", "evidence": [ { "database": "Reactome", "id": "R-HSA-9662360", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9662360" } ], "reference": [ { "type": "PubMed", "id": "11163272", "url": "https://glygen.org/publication/PubMed/11163272" } ] }, { "title": "Exploring the human leukocyte phosphoproteome using a microfluidic reversed-phase-TiO2-reversed-phase high-performance liquid chromatography phosphochip coupled to a quadrupole time-of-flight mass spectrometer.", "journal": "Analytical chemistry", "date": "2010", "authors": "Raijmakers R, Kraiczek K, de Jong AP, Mohammed S, Heck AJ", "evidence": [ { "database": "iPTMnet", "id": "Q9Y6V0-5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9Y6V0-5" } ], "reference": [ { "type": "PubMed", "id": "20058876", "url": "https://glygen.org/publication/PubMed/20058876" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "iPTMnet", "id": "Q9Y6V0-5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9Y6V0-5" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Human Alzheimer's disease synaptic O-GlcNAc site mapping and iTRAQ expression proteomics with ion trap mass spectrometry.", "journal": "Amino acids", "date": "2011", "authors": "Skorobogatko YV, Deuso J, Adolf-Bryfogle J, Nowak MG, Gong Y, Lippa CF, Vosseller K", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9Y6V0", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9Y6V0" }, { "database": "O-GlcNAc Atlas", "id": "Q9Y6V0", "url": "https://oglcnac.org/atlas/detail/Q9Y6V0" } ], "reference": [ { "type": "PubMed", "id": "20563614", "url": "https://glygen.org/publication/PubMed/20563614" } ] }, { "title": "Exploration of peptides bound to MHC class I molecules in melanoma.", "journal": "Pigment cell & melanoma research", "date": "2015-05", "authors": "Pritchard Antonia L, Hastie Marcus L, Neller Michelle, Gorman Jeffrey J, Schmidt Chris W, Hayward Nicholas K", "evidence": [ { "database": "IEDB", "id": "542267", "url": "https://www.iedb.org/epitope/542267" }, { "database": "IEDB", "id": 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"date": "2017", "authors": "Zhang W, Hong R, Xue L, Ou Y, Liu X, Zhao Z, Xiao W, Dong D, Dong L, Fu M, Ma L, Lu N, Chen H, Song Y, Zhan Q", "evidence": [ { "database": "RefSeq", "id": "NP_055325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055325" } ], "reference": [ { "type": "PubMed", "id": "28263981", "url": "https://glygen.org/publication/PubMed/28263981" } ] }, { "title": "A novel strategy for global mapping of O-GlcNAc proteins and peptides using selective enzymatic deglycosylation, HILIC enrichment and mass spectrometry identification.", "journal": "Talanta", "date": "2017", "authors": "Shen B, Zhang W, Shi Z, Tian F, Deng Y, Sun C, Wang G, Qin W, Qian X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9Y6V0", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9Y6V0" } ], "reference": [ { "type": "PubMed", "id": "28411811", "url": "https://glygen.org/publication/PubMed/28411811" } ] }, { "title": "Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder.", "journal": "Twin research and human genetics : the official journal of the International Society for Twin Studies", "date": "2017", "authors": "Mbarek H, Milaneschi Y, Hottenga JJ, Ligthart L, de Geus EJC, Ehli EA, Willemsen G, Davies GE, Smit JH, Boomsma DI, Penninx BWJH", "evidence": [ { "database": "RefSeq", "id": "NP_055325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055325" } ], "reference": [ { "type": "PubMed", "id": "28540843", "url": "https://glygen.org/publication/PubMed/28540843" } ] }, { "title": "Quantitative proteomics identifies altered O-GlcNAcylation of structural, synaptic and memory-associated proteins in Alzheimer's disease.", "journal": "The Journal of pathology", "date": "2017", "authors": "Wang S, Yang F, Petyuk VA, Shukla AK, Monroe ME, Gritsenko MA, Rodland KD, Smith RD, Qian WJ, Gong CX, Liu T", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9Y6V0", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9Y6V0" }, { 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Fan C, Melicher MS, Orman M, Benjamin T, Walker S", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9Y6V0", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9Y6V0" } ], "reference": [ { "type": "PubMed", "id": "29485866", "url": "https://glygen.org/publication/PubMed/29485866" } ] }, { "title": "The natural HLA ligandome of glioblastoma stem-like cells: antigen discovery for T cell-based immunotherapy.", "journal": "Acta neuropathologica", "date": "2018-06", "authors": "Neidert Marian Christoph, Kowalewski Daniel Johannes, Silginer Manuela, Kapolou Konstantina, Backert Linus, Freudenmann Lena Katharina, Peper Janet Kerstin, Marcu Ana, Wang Sophie Shih-Y\u00fcng, Walz Juliane Sarah, Wolpert Fabian, Rammensee Hans-Georg, Henschler Reinhard, Lamszus Katrin, Westphal Manfred, Roth Patrick, Regli Luca, Stevanovi\u0107 Stefan, Weller Michael, Eisele G\u00fcnter", "evidence": [ { "database": "IEDB", "id": "1109146", "url": "https://www.iedb.org/epitope/1109146" }, { 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"https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "GATAD2B O-GlcNAcylation Regulates Breast Cancer Stem-like Potential and Drug Resistance.", "journal": "Cells", "date": "2025-03-08", "authors": "Le Minh Giang, Merzy Jessica, Esquea Emily M, Ahmed Nusaiba N, Young Riley G, Sharp Ryan J, Dhameliya Tejsi T, Agana Bernice, Lee Mi-Hye, Bethard Jennifer R, Comte-Walters Susana, Ball Lauren E, Reginato Mauricio J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9Y6V0", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9Y6V0" } ], "reference": [ { "type": "PubMed", "id": "40136647", "url": "https://glygen.org/publication/PubMed/40136647" } ] }, { "title": "Ferroptosis-induced remodeling of glycosylation the immune microenvironment and improves survival in pancreatic cancer.", "journal": "World journal of surgical oncology", "date": "2025-12-05", "authors": "Tan Hao, Zhang Haitao, Gao Jiacheng, Wang Lei, Luan Xiaofeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9Y6V0", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9Y6V0" } ], "reference": [ { "type": "PubMed", "id": "41350704", "url": "https://glygen.org/publication/PubMed/41350704" } ] } ], "pathway": [ { "id": "hsa:27445", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:27445", "resource": "KEGG Pathway" }, { "id": "R-HSA-9662360", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9662360", "resource": "Reactome", "description": "Sensory processing of sound by inner hair cells of the cochlea" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M3AJG6-1", "protein_name": "Protein piccolo", "gene_name": "pclob", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MFSSNFLSGGNPLSAMSSAVNKFGLFGDETSEEKQQQQPPGSSKQKDHQQQGNGQPASQGPQRQSGPQPQGMGRGGQGVGRGGSQPQGAGRGGSQPQAAGQGGSQPQGAGRGGSHPQGAGRGGSQPQGAGRGGSQPQGAGRGGFQPQAAGRGGSPVLQGAGRGGLSQQGAGRGGLQHGTGGGESPKHGVGKGGPRGPGSRPPSTEPQEKSGSGAGVKTLCPVCKNTELNLKSKDSLNHNTCTQCKSEVCNMCGFSPPDATAKEWLCLNCQMQRALGGAESSGPPTLKAQSQPKDNVPSQNLAKKDTPHSKQMPPSASPPTKPTQSQKQSSQSSTSAAHTSQQTTQQKPPTKQTTQGAPPAKSEPPSKTDPPKKEEESSFFGFGFGGTRSRSPSPQPGASSVSGKVLGFGSSFLSSASNLISATQDENSTTPPTSRKGSTISQTSAKITTPPSSRKGSEASKGSPNLSKSLMQEGKTQQQQNKPQDTQKPTTITESPSAQATKVDQSPKLPPKSCPLCKALLRKDPLNYSTCTECKTIVCNQCGFNPVPHQTEAKEWLCLNCQTQRALKGIEPPGQPTIKSKTQPSKSNKMDSTLGPLEKQSSTLPTMASPANQPAAHKKEMHEQQTSAVGAKQAPSTKPVQQQTVKNASSPSVSKASPKAEAEQEQSGFFGLGFGGARSRSPSPQPAVSAMSGKVLGFGSSFLNSASNLISSAVQDEPSTTNSQATSVSQISLKTNTPPMPRKGSTTSNENQSVGQKEDKKIELTADLNNKAPISQPKKGEPSLLMPKADKNPQPLPKSCPLCKVEIKKDLANYQICTECKTTVCNLCGFNPTPHQTELKEWLCLNCQTQRALKGMEPPGPPKLESAAQAKKQPASKPLVSPLIQKEGASELDKLGKKIGPPQKLQDQQSKAPNGALPIQKAQQQEHEAKSEVSAKSAKEESGFFGFGGARSRSPSPQPAVSAVSGKVLGFGSSFLSSASNLISTAVLDETSTTPPTSRKASTVSQGSTPTTSRKSSAVPQMSNTGDTTQTTAEKQETYQQASKSSMNKTADKSLPTKVDKTPLPLPKSCPLCKADITSVPPNFSSCTDCKTIVCNRCGFNPMPHEKEVKEWLCLSCQIKRASEPSSLDPKLQSKLGLQQDKRVQHQPPPQNVLNEKSPAQKESIKPQQPKDASVSAKSEITTQSDSSKTDTGFFGFGFGGVRSRSPSPQPVVSEKVLGFGSSFLSSASNLISSVVQDESSTTPPTPRKGSTVSQSSVKSTTPPTSRKDSLTVAATSRKGSTASQDSVKTQPGETKILSQKLMEDKKSLQDQILKAPSTSPSKPQSAVKSSQLLVKNCPLCKVELKKDPPNFNTCTECKSIVCNLCGFNPMPHQTEANEWLCLTCQVQRASVPKDQAKITTPVPKKEKDLPESLQKKQHTKEATNAGHKSPVAGGKEPTADLPQQVRQPKTQQQMKSDKPLENQSELPPKTEPHQEGSGFFGFGFGGARSRSPSPQPAVSGKVLGFGSSFLSTASNLISSAVQDEPSTTPPTSRKSSSVSETTILPGSRKGSSVAMQESQKTQPSKDTKPSIEQKKEEKTQLLQQVNVPSRELKDNLKMTKDSPKPLPKVCPLCKVDLKKDQYNSCTECKNIVCNLCGFNPMPHQNEVMWLCLACQMQKAPEPPPVQLQSHAKKPEDTVQMDKKPQVPGKQDYKQTSAATVQPAQKETQKQHITDVSKSESQKTDPQQDKVGFFGFGFGGARSRSPSPQPAVSERVLGFGSSFLSSASNLISTTPQDESSTTPSSSRKASTASQMSDKTPPTSRKGSAVSQISNKVNTTPASSRKGSQTSIKTTPPTSQKGAEADVNINNADGAKTKVPEKGEETNNLVTSQQQEQGKAQDGASLSSELHEDPRSRSQSPLLPPAASAVSGKVLGFGSSLFSSASNLISSALEEPSTTPPASRKGSTASQLSAKTTTPPPSRKGSSVSQTSDKIATPPSSRKGSGVSLTSAPGPTQKKTLDPDATVKEKAALLTGTPESIQKKRKDEKPMVSQAQPTTTKDAALPETRTKSPISLPKACPLCKVDLQKEPPNFDTCTECKNTVCNRCGFNPMPHETEKKEWLCLNCQMQRAQAEANKVAPPVSPLKKTTPAPVPISEKEKTAVSSGTPEFTKENTITPKQKPQQQEDIKKIAQPSLNQSTAPSKTAPTKEESGFFGFGRSRSPSPQPAASSVSGKVFGFGSSLLSSASNLMSTAVQDESSTTPLATQEDSAPSKTLVKTTLTQATTQGGSADLSPKQGAKSVQENQKDKEQEGKMKEIQAKAVIKEEVYKSEPPKACPLCKAEIIKNPPNYSTCTTCKNTVCNLCGFNPLPHQTEMKEWLCLNCQIQRAPIPPAGQPGPQTTKLPPPASPQKQHTPGVVAEDQKLDASGQHKIKPNSADLKPPTSEAQKQKSEVLPAKSDQPHKPEPSKQETDFFSFGFGGSQSRSQSPQPTVSAVSDKVFGFGSSFLNSASNLISSAEPSKTPPTSRKGSTISQTSSKTIPTPPTSRKGSVAPPESKLNPPPVQSKPTSTPTQEQKGPPDVQPSKPLEAELNKEPPKSCPLCKETLKKTPQNYSSCTSCKSIVCNLCGFNPNPHQTDVKEWLCLTCQMHKTSGPPLPQPEPQSNIALAPASPLKEKTQVSPSPEKKPSVTADQDKKPLAETKELKTPNTQKSKGDVPSSKPVPPPKGEQVKEESSFFGFGFGSSRSRSPSPSPQAAVSDKVFGFGSSFLSSASNLISSAVQDESSTKTPPTSRKGSTVSQVSNKTTPTPPTSRKGSVIPQDAKQKQPQRESKPAVSSIQDQKPVSKTQDPQLVKPAHTSEEISKACPLCNETLKKDPQNYSTCSSCQKSVCNLCGFNPNPHQIEMKEWLCLTCQVERASGPPPAQQQVPLASTQKKVTLEIKQTVTVEQDKKLTEAKEPTVTPTAYAQKSKDDTIPSKLAPTSKVEQNKEDSGFFGFGARSRSPSPQSAVSGKVLGFGSSFLSSASNLISSAIQDESSSKTPPSSRKGSTVSQSSIKTAPTPPTSRKGSEAAQAVQKRKVVEEAKVTVVQKKDDKKIEENKSQDEKPKVPVDDVQSNTPVPELSKVCPICKVDLKSNPSNYNTCTGCKTTVCNLCGFSPMPHQTKVKEWLCLNCQVKKAQEFPSAQPPPMASKASQPTKSQDMDSPIPSKIPVSSLNMTDVIGTKSASVATENQESKPTQASSPVPQMPKSDPSPTKHAVSQKAEPLKEEAEFFSFGFGGARSGSPQPSVTAVSGKVLGFGSSFLSSASNLISTAMQDDSSTTPPTSRKASMASETSAKNTTPPTSRKASVVSQTSLKTTPTSPASRKGSVTSQQIPPTGDTSKAPIPDKTDVKQVQQATTVPEPVIGAVTAPKAETKTCPLCKVDLNIGSKVTPNYNTCTECKKIVCNLCGFNPTPHQTEFNEWLCLNCQTQRALNGIKPQEPSKIKTHEQPDKVFTPALPQKSESITPGSSSTTIAPDSVDGTQKKEIQAVAISDRTKPAVSADVQKKEAVTGSPKPPESNIKGPPVPSSESDKPPEKATPNVQTEPPKQESSFFGFGFGSPKMQPASPKSSESTTGKLFGFGGLTETARSRSPSPQSVSAVSGKVLGLGSSIFSSASNLISSAVQDEPSKTPPTSRKGSTVSQTSTKATAPTSRKGSAVAPDSSKVSPVGDTKTQAAQDVEKKTEIKQVTSPKPPEKSASKEVKTNCPICKVKLNIDSKDAKNFNTCTECKMTVCSQCGFNPMPHQHEVEEWLCLNCQVQRAQQGVKSPSTLPQSVPLLKDDKTTSKADKEAPAPVDTKPDENPAAVPTKKKAAPDQEIKKDILVQKTSSDAKPTDKITSSKDLPKQDNTKTEPEKSQQPPTKDTIIPVKSAPPTETKPPKQESSFLGFGLGGPKAQPSSPKPTDSGTGRFFSGFGGLTETARSRSPSPQSVSAVSGKVLGLGSSIFSSASNLISSAVQDESSKTPPTSRKGSTVSQTSTKATPPTSRKGSAVAPDSSKVSPPEDTKTQAAQDVEKKTDIKQVTSPIPLQKLAPKEVKTNCPLCKVELNIDSKDAKNFNTCTECKMTVCSQCGFNPMPHQTEVDEWLCLNCQVQRAQGGIKSPPVNSQTVPLVKDNQTTSKVDKVAPVESKPDENPTAAPIEKKVVPTQEIKKDISVQKTSSDAKPTDKITSSKDLPKQDKTKTEPEKTQQQPTKDTIIPVKSAPPTKTEPPKQESSFFGFGLGGSKAQPPSPKPTDSATGRFFSGFGGLTETARSRSPSPQSVSAVSGKVLGLGSSIFSSASNLINSAVQDESSKTPPTSRKGSTVSQTSTKATPPTSRKGSAVALDSSKVSPVGDNKSQAVQDVEKKTDIKQVTSPKPLHRPAPKEVKTNCPLCKVELNIDSKDAKNFNTCTECKMTVCSQCGFNPMPHQTEVDEWLCLNCQVQRAQGGIKSPPVKPQTVPLVKDNQSTSKADKVAPAPVESKLDEDSTAAPTEKMAAPDQEIKKDISVQKTSSDAKSADMITSSKDLPKPDNTKPEPEKTQQQQQQPPKDTITPVKSTPPTKTEPPKQESGFFGFGLGGPKAQPPSPKPMDSATGRFFSGFGGLTETARSRSPSPQSVSAVSGKVLGLGSSIFSSASNLISSAVQDESSKTPPTSRKGSTVSQTSTKATPPTSRKGSAVAPDSSKVQPTEDTKTQAAQDVEKKTDIKQVTSPKPLQKPAPKEVKTNCPLCKVELNIDSKDVKNFNTCTECKMTVCSQCGFNPMPHQTDVDEWLCLNCQVQRAQGGIKSPTVKPQTVPLVKDNQTTSKADKVAPAPVKSKLDENPTAAPTEKKAGPAQEIKKDISVQKTSSDAKPTDKITSRKDLPEQDNTKPEPEKTQQQPPKDTITPVKSAPPTKTEPPKQESGFFGFGLGGPKAQPPSPKPTESTTGRFFGGLTETARSRSPSPQSVSAVSGKVLGFGSSLFSSASNLISSAVQDEPPTTPPTSRKGSTVSTDSGKATTAPASRKGSVASARTTPLTPRKGSVTTETDNNPPAKEVIQQVEKKPEQVSVDKLSSIPTSEKDTPESGRDILLTHPESLPQPSTCPLCKIALNMDSKDPPNYNTCTECKSVVCQLCGFNPMPHLAEAEWLCLNCQTQRAITGQLGDMGKIPIAGPVSAKDKPTVTSKTQLPETPAPTQVAAPQPELKPSTEKQAKEEKTTVEKAAVTTPAVPASLSVVPTTYLPQTEMTAVVAPIPAAESQKAVVTAAEVTLTETGRDKIPDEIKVERGPISMIPAATVEADVVKVKEDTYTHPTTEGQLDNVVIQIDTSLTEISKVDTLKADTKEQQRKDILPVSVESYSSAEEELKEIQRVSEMAMKETAAKLLPVRAQDNVKQYHEDSSESEPSPQIQRRRVRPPSSSSEDYKIDSSNSGDDEEFIRRQLMSMGEDENLPSDEENIVKEQLDASQETKEVDSMKPKRALKKLTVEPEEYLSSHDQDDQVVQVIPVSEALEVSSVEIDVSVDNKITVTDTIAAAVTQKSPVRQTTEEYESLVEDSSKGDGSSSVQVSSITPGTASPTSVSSIDEDSDSSPSHKKARAESKQQRKAKHRPHGQALATIEDSSEEDGLHEKGDQPMELEEERDDQQPLRKASRKMKTEKDELVMQRRRDHLTKTDKLRQVAGTEERKSSSFSDFSPSVESDAESAEYRTLSSETQEAAGKPLKNAEEVYEEMMLKAQEYKTSEKFTPPDIEPLYGGMLIEDYAYETLVDEQDQAAAAFGNFTHGQDRESVRILMTPDEAYEEMMRKRSKIVLKEEEAQQTYTTKIDTSLPLDDSDTCFVTISGNDALAADKNSKTLLQTEDAYEELLKAQKDVLTPGTSPTPSTPLSPASPLTVSESSYDSPEVILIPSSGEEDNLAEPIECILEPYITESTSTQDAFVNKTLYPIPDLKITQCSSGEDEIEEEDIARQEQISPEPTDVSLSEEEPQAPGELFENDPISVVCEVPSSKYVVETTTLSPLSPPTSPAISSPDSNLELATAPSSSPMSDQTSELTTPASPSVADVSVPVVIHMPDLMDEQTTVHPSIAASAQTIVSSSPAILASHHVSEDASTPAPPEVLASKPTQGPKPTLAPKPTITKTIQQAVPSPEWVSTNTVDSTQKPLAGAIHEPTSVTKSAITDKPTVAPMTAEKVDHVKMSTTPALTPIVQSQEKPLIETSIVVQMPDHISSSLKHPVVEQTPVSAPTLPSTTLKNQVPTAIAIVATMPDTLLCQVTSTSQSVEQASTSVPTMVPSSVPASIVSTDPTSSAVVQVATPPSAHTTLPALIRDVQPPASVSIQIPIQRLVETRSDIAPPLHQATPISPPVSHMECIAAKTVSVVSPTITTTVAFENSLSHPVKSMLADSQPTMTQIPQKIIPDNAIPPIEQKPQSQISFRLPNLEKTVNDEKVQPVIVSVSPITYAATVSSFVSPCVASAKPYISQERTDKPVISFPPPPLATPPELPYSTVPRSDFDQQMAFQTTSSVTSSQPNPPATVASVTVKAAVTPTHKSPPPVPPKPVCIPPGLVFSHRSRESIKPPVSPEPVVVQAVRAATLPRTREPPNALTLSLTAPIETKHSASSPKSPLSPRFARTLETYVVITLPSEPGSPVETITTQAPIRRSSLPTSRQQVTCDAPIVFIPAAIDAPVSLISAQVVAAPPKPPPALKTAAPFGGMAPDFASTTMETYYALPEMNLTQSIAPPCVTVPELPVTSDPMLVEAPRLVTSSELAQTMSFIPHISMGNVTHSPSEFVTPHYSAPVEMAPPALISAAPVAAPPLPPTSVEPTVYHAMVHTTPSMVCPPPMASASTLYTSKPLEELPITLTPMSGAPAVSVPQNTVSDVRKELEMQQVQTAYSVPITITQIPIQAQNEDIPGLDMEEVLIVSAPEEILTDLGPTPVPITQQTIYEEKTEIPSMTSATAVPPVPVTFTQFTKSIESQEICGQDKFISSMSQVYSAISTTEQHPDTLPKLVTQVVTTEVQRTTTVSVVQERIPVDPIPEPVSATVTIQPEVHQKSKQNGRIHYPTDVVDLTTFKVNVTMTDSGMDLTAPDSSRSFLSSESSGRQATAVQPEIVNLSAEIIPSPTLSVVNDSITIVTCTATIAYNNNSTVDKPLDLGNATSVPLSLTTYNPFEPLAQIVYRPVNSQPKPPASAEIPVNLSNRSATISAPPLMPLTVAPVSFTNGTVGIPMHTEPSVVGPVDLTTSKPLNTMVALSSSSGVVTNVVEDDGTPVDLTSGRRTVCCDVIYRLPFTGSCRTQPPVTTQPDTQIGYEIDDAEMPVIENLSTMKTSISDSNFKETGLLSYERKNGFTYQNGAPEGAMDLTSAKMSMEEALDYSKKGTLAFTGITSTPYSQGTSYGVNSLLRSTNGIVYSSVAAPVPSTYAITTQPGSIFSTTHNSLTDPTEPLSAFENQPAPYGFVHTATDQSIFSQSDISKDILPSALASLLPSLTAFPELYSDATLEAIAASLDTLVSPNFPDLDDSKSQQYKAEHEFLQLEKLKQLCLAEELEWERQEIQRYREQEQFIVQKELEELQNMKQQLLMQQEEERKAQLILQQETFAQQQHQLEQIHRLQKQLQQQLEEQKIYPYGFGPIEGMSPPMGSNIILDSKYSGGDNGQYWPVKDDNSMSSAVSTHDSTLVQNWQSTTVQHSSNIPVTVSAQTKEQMQLSTNMSDSAKQEQNLGLSGKKLIESGVQTDDEDEVEKIPSGRKRRSRRSVDSCVQTDDEDQDEWDVPVRSRRRSRSSRYADGEKGKSSKVSSIAIQTVAEISVQTEHSGTIRRSPVRAQVDTKVDLQREGQTESDSDITSDKDKRRPVPTGITVSTHLTADDVGTSMVTKSPKVLCSPVSPMSPGKSSQKMLTADSSRHLSSPRSLRASQRSLSDPKSLSPTTEDRMMYQYSETYSSKGSQSGTPVGSYKKVKRTLPHPPPEEDNIIGLSGYTTSSTRRRMCRNTTMARAKILQDIDKELDLVERESSKLRKIQAELDEEEKEIDAKLRYLEMGINRRKEALLKEREKRERAYLQGVAEERDYMSDSEVSNIREARGNGHGLERPRTAPQSEFNQFIPPQTESESQYAQLTSPYSHYQYASQTSQYPQQTLYQQQSLYHQQVSPYQSIYSSVPSLNQQSQQTGYDHSSLLLMQQKPRQTTLSDLEPKITTNYEVVRNQPLLIVPTSTESAYGVSHLGGKYSSLDLRMGLEERASMASSPMSSISAESFYADLDHHNARNYVLIDDIGELTKSSTGLGSSYSIADKDISKADRLLRTADIRRTADVADFLSPLQSASRLHSYGKADEDSMEEPYELKMLKQQIKQEFRRGTDSLEQLTGLPHYLHSDTSFRHFPKAEKYSIGRLTLEKQAAKQLPASVLYQKQLKNKKALIDPKITKFSPIQESRDIELDYSNFLASASSVGGLSARARLLQDEITFGLRKNLAEQQKYLGSALGANLAQSLNFGQSLNLGPTIRSSLHEDGTYPSGTRSRPSSRPSSVYGLDLSIKRDLSNSSLRLKTEGEGMDSQFVSRAKPTSLPISQSRGRIPIVAQNSEEESPLSPVGQPMGMARASAGPLPPISADLRDQFGSSHSLPEVQQHMREESRTSGYERDIAFIKDDLQGAMSDSEAGGPSWNVKAYHLQHEETDWFDKPRQGRGGPESGPDRRQMKGSHYPFPHTRIKLQRDPKDHSVSGSGLGIRVVGGKEIPGTNREIGAYIAKVSAGGYAEQTGKVVEGMQVLEWNGISLLGKTYEEVQSIVGQQNGEVDVCVRLDLNMLSNTEQPQQLELHNQLRAGERQRSPGVDPKQLAAELQKVSQQQGPASVLSALERAGHLHSGPGSAASSGVPSPGQPGSPSVSKKRHSSKSAEALKPQPHPITGDIQLQINYDRNMGNLIVHVLQARNLAPRENNGYTDPFVKVYLLPGRGQVMVVQNASAENKRRTKYIQKTQNPEWNQTVIYKNIHLEQLKKKTLEVTVWDYDRYSSNDFLGEVLIDLSNTTQLDNTPRWHPLKEQSESIHHGRTHPPQGPGGSGGFGGQGGSGGQRGPGGTGGSGGQGGQPGNQESPKTSVIKSRSHGIFPDPAKDTQVPTIEKSHSSPGSSKSSSEGHLRSHGPSRSQSKGSVTQAHLEEAGNAIAAAEAAVHQSRLQPNKTNHRMTDGEGYTLDSEDSMGTNALDSAIFQVPQMKNIPNGTDKTRGLESLNLPDSEGKMMGEIKVALKKEMKTEGEQLVLEILQCRNITYKFKSPDHLPDLYVKLYVVNVATQKRIIKKKTRVCRHDREPSFNETFRFNLNPVGHSIQLFLVSNGGKFMKKTLIGEAYIWLDKVDMRKRAVSWHKLVPTTSQTQP", "length": 9355 }, "evidence": [ { "id": "HGNC:13406", "url": "https://alliancegenome.org/gene/HGNC:13406#orthology", "database": "AGR" }, { "id": "RGD:69406", "url": "https://alliancegenome.org/gene/RGD:69406#orthology", "database": "AGR" }, { "id": "MGI:1349390", "url": "https://alliancegenome.org/gene/MGI:1349390#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-030131-8100", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-030131-8100#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0AC58J9N3-1", "protein_name": "Protein piccolo", "gene_name": "pcloa", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGNEASLEGGEAGLPAGLAPDGKGGFIQMPAGVEADLSNLSEEERKQLVAAMARAQSRPPETQAGGTKVPVGLSKSRTVDAFGEGPPPKPKPGRSPSSLSLLESRFRQEPKDPEQPRTGMFSSGFLSGANPLSAVSSAVSSASIPKFSLFGDDEEEESAKQEGKPPGPQSGVGKGPPQGSKPPQQGPPKGQGPLQQGPKPGGPGPQQGPKPGGPEAQHQAPKPGAPGPQQGPKPGGPGPQQQGPKPGGPGIQQQGPKPSGPGPQQQGPRPGGPGPQQQGPKPGGPGPQQQGSKPGGPGPQQQGPKPGGPGPQQQGPGKPGPGVAGKPSGPQQQGKPGPGALSEGPGKAAPAPGKAMCPLCKSTELNVQAKDQPPNYNTCTQCKQQVCSLCGFSPPDSASKEWLCLNCQMQRAMGGMEPPGPPMMKQPPKQGSAPPSPQRKEPPPGSPSKVEPGKKPPMLTKQQSIADTGKGSTPPTTPKSGPQQGPQPGQLGAKRGQPPPLQKPSQSPKGSPQPSPAKTTPKQDGGGFFGGFGLGGLTEVTKPSPAAQATESVTGKLFSGFGGGSKPQGGSAAPASESVTGKLFSGFSGLTETTKPLPAQSQSTESVSGKMFGFGSSFLSSATNLISGEESKSPPDSPAGSPPDSPIGSDADSPAGSPPDSGSESPPDTPPAYSKDPASPKPTPAEKKASADTSPPKSTDVKEAKVSGSEAQSCCPLCKVKLNFGSGEVINYSTCTECQKTVCNLCGFNPTPHLSEKEWLCLNCQTQRALSGQLGDMPPPPSPSKLPAKHEPTPPSSPACATSSTPSSPAPTAIPAKGLTRMPSITQAPADKSEPVSAKTDAKEVKNTDAEQGVTAEPVPRSTQVVPEESKEQALGTLTENTEGVTSLPEHTVNEDAPPLHSDSDKRADVKGPDVEQAEALQQSEAPAEVQKAEESEPEQCQVQEPECTNTVELEPGSGQEAPIFDNTQTLLVSDNEAIQEKDIEPQSTETLEAATQIEITESSASSPISTEPHSQTTNRQAGEFTQPSHVDLEDSNPVNEICIETATADPDQRSIGDVPERKPEASVQIEAPATGPSDDQLSHNITDQEQPENKTNQLKPVEIEVVEQDIIDNKLLELSPQNNLNVCDTEALIAQMPETKLPLDESEVTNTGSCLVGNDISVDKKDENSEKNVKEDKTNVDNRSQLDEPTSSLVTEVNFTEDILANGAANVSKLSPNEQCTEELFEEKVDNPLEKEQMSAGKPELGKCMPDQTGGDLEILENTDQNVTLKTESDNKKIDFSSESTFYEQETNFNKNIEESNNGDACPPALQEGAPEPEKETTETEKVHVNKAESDTDITENVTERVVIEDELSSGNNKNVTETVEQLLPKEKEIPDRVTEKPREESDVLGSLSHQKIGVSSSNVFCTKDDIPPVIEMHHTQQAQTPAITEIAEKLIAEEINICQIPESLMENGSEQSVMPGAINSQNIEVPSSTPVSKNEDIKTLITSEEIQSTQQSQTFVTDLEITPKSKLESRVECVPDVELESPPSTFSQQERNKSEHGMLASEQEKQDDVLQPLIKTNKIESEENKEAAAPVKENELLKEPSEKDKESSPTSPSDLAKLESTVLPILEAQKSPKDESKSETPKVKRRLEVLPMSPEPSSEDDLHGETKEQTNNAPKKERKKLLIPTDIQGDSFEDSSEGERSPEQREKTIGDKGEIESPMDEEDFIRKQIIEMSADEDASPSDEENLVRRKIKDQEKKQMDKNARKDDKEKSESGKTRRLLKSTSISPEDEPERKSIISVTKIEELGKGEQPSADSGAGIRHFKTIELNSTATVRQTSDDGEPESLTDSPDDRSRGEGSSSLHASSFTPGTSPTSLSSLDEDSDSSSPSHVRSSGEGKQQRKAKHRQPGQMLPTIEDSSEEEELREEEELLREQEKQKGSGKKSKKDKEEIRAQRRRERPKTPPSNLSPIEDASPTEELRQEAEMEEIRRSSCSDLSPSIDSEPESFEILPEKIVAVQKVYQLPTSVSLYSPTDEQHADNQSKEKGKQSLKTAEEAYEEIMLKAKSPTNEGKESPPGKVSLYGGMLIEDYAYESLVDDASCEQEPEKLNVSEKPKKPLRSPDEVYEDMMQRKEIMIKKHELKHDKPMEDVPKPETELVNTVSSKETVSSSITGQSGKDGRPLLDAEAAYEELMKKKKAVLTPGTSPTQAGPDLSGMAQGTTGVQVEKTDTTPVRRILPIPDLRVTQCSSGEEESGEENFADQTQDSDKPTVSTTKTASESAVDEAAQKTSASEPVADDLSLQREVKSPVISSDSKDATEKDVGNEQAGVVDLSKSSTPSQIDTFSASAPSEISGQSAPVVVSVSPLSTVPQYIVSSVPCVVSTAPPVPPKPVILRRAASLEKEEIPVPPPLPPPTLPKPSVYPKKTPPQVPPRTTPVGMPTTGDSVPIKQPLGQGYKPHVPPPVPPKPSSIPAGLNFSHKQGESFKPPIAPKPMAGAQPSLTAHTPTRPTILTTSSADNVLNLSPSAESRTGTTSPLKSPTSPRFGKVLRDTYVVITLPSQPSSPTEGITTQASISPSQESHQKLPPSPPQPTQQSQTTRVPLAFTRITESIESQEICGPEKVVSSMSHVYEAISASTQPQTVIPNVGVQVVTTEVQRTTVSVVHERTPPPHPMPRATGISVVQETTKPEAVQIQNGHAYHPGEVVDLRTPKIDAVTSMKGIDLSSSESRRQSLAVDSGGRQQSAVQSSVVNLSTDTSSVSVVTDNITILTCTATVAYGSDASLATSVPLQLTTAKSFEPVSQIIYRPVDCQPEKPINLSTTMGKTHSLPVTIAPTMANNGISAALPPNLETGLSGAVDLTTVKPAQTMVAMNGSTAAVVTAVIAEDDGKPVDLTGGRRAVCCDVVYKLPFASSCATQQPSAPLPEDRFGYRDDHYQYDRSPYGMRGLGGIKPSMSDTNLAEAGLFLYKSKHSYDYKDATEGAVDLTSGKMSVGGEAVDYSSKTTGVCTGMTVPQYTQARITSVVGTNYGVSSVLRSSNGIVYSSVAAPVPSTYAITTQPGSIFSTSYNTLSGMHTSDTMPSLSNLQNQPLTRSHSFLSTIALTTAEGQIDLPLNLETSASRAGLSSTLSGEVSTVTTVTGLDTYTNASLDAIAASLEALSSPMVPGDGQYQMEREFLELEKIKQQRLAEELEWERQEIQRFREQEQLLVQKELEELQAMKQQILCQQEEERQAHLMMQKETYAQQQEQLEQIQRLQEQLRQQLEEQKFRQMYPGEVLPEALVVTGERKMDSGCQTDEEDNTEKAYTAGRKKKTTKKSVDSCVQTDDEDQDEWEVPARGRRSRPRGGKNGMAERGAVSVQALTEISVQTDSGTLRGHSVQVDARVDYPDSDRTSSPKRRPIPLDIGQSPLLKADASTLQVAPGPPKSPKVLYSPISPCVSPSKSLEYLSYEKPLGETSPQRIRSVTDLSKGPPTSPRAPKVIQRSMSDPKPMSPTAEERAAANFQYSESYSAKGSPSGTPSGTQKKVKRTLPNPPSEEEAANAGQAAYSTGSARRRLCRSTNMARAKILQDIDRELDLVERESSKLRKKQAELDEEEKEIDAKLRYLEMGINRRKDALLKEREKRERAYLQSVAEDRDYMSDSEVSNIRETRGGEDIGGHGLERPRTAPQSELDEFVPPQTKHDQYGKYSQYQYSQYQQSLYQPQSPYQSQSIYSSVPSLTASQQQSYHQMLLLQQKARQQAALLSELDSTKIASSYDTSSYLGGKYSNHLDLHSLEDRAGSMAVSPMSNVSADSFYSDLDQHQTPRSYMLLEDAAELAKSTGSLSSTSYGIAERELAKAERLLRHAAADVSSDYLGSSSRLHSYGKAQDEEDPMEEPFELKLLKQQLKQEFRRSTGGTESLEQLAGLSHHYTPSTGVSSGGYRAYPKTEKYSISRLTLEKQAAKQLPTSMLYQKHKNTSNIGKYSSMQDSRGLETDYSSYLGSSSSSPRSSRLMQDEITFGLRKNIAEQQKYLGSTLGANLAGSLNLGQSLNLSPGMRSSLGEDSSYPSGSRSRPSSRPSSVYGLDLSIKRDLSSSSLRLKAEGEASSETSAFQTPSGRSKPTSLPIVQSGRGRIPIVAQNSEEESPLSPVGQPMGMARASAGPLPPISADSRDQFGSCMSLQESQQQHLREDPSRGRGYVLMDDLQGTMSDSEALSESLVGLSRDDPGNSHENVTNAYHLRREETDWFDKPRDGRAENGQGMERRQGKFHYPFPHARIKLLRDPKDRSVSGNGLGIRVVGGKEVPGSNGDIGAYVAKVLPGGAAEQTGKIVEGMQVLEWNNISLSGKTYEEVQGLVGHQVGEAELCIRLDINMLSDSDSSHLDLHDQVKGDRPPRSPGVDPKQLAAELQKVSQQQVPSSSASALDKPSASAGSSAVPSPGQPGSPSVSKKRHSKNSEGTKTQSHPVSGEIQLQINYDKQLGNLIVHVLQARNLAPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAENKRRSKHVQKTLNPEWNQTVIYKNIHLEQLRKKTLEVSVWDYDKSSANDFLGEVLIDLSNTAQLDNVPRWLPLKEQSEGEHHRRSHSGQGRQHSPKPPGGHGSQHSPKTSGHSKEDSPKSSVIKSRSHGIFPDPAKDTQVPTIEKSHSSPSSSKPSLSEGQARPHGGPRAHGKSGTTRAHLDDAAAMAEAAGQQPRLQPTQNGGLDPRHHRHSVVGVLTIQRAPSESPAHEVPDGRHLTLRKALSEERPQPDGASRSHRSGDAPVTAASLDSGLSGSAFSLLDEEGGTNAVDSAIFQVPRFGKIPNGTEAVKSAHGDAEGKTQVMGEIKIALKKEMKTEGEHLVLEILQCRNITYKFKSPDHLPDLYVKLYVVNVATQKRIIKKKTRVCRHDREPSFNETFRFCMNPTGHSIQLFLVSNGGKFVKKTLIGEAYVWLDKVDLRKRVVSWHKLLASTAQIHS", "length": 4953 }, "evidence": [ { "id": "HGNC:13406", "url": "https://alliancegenome.org/gene/HGNC:13406#orthology", "database": "AGR" }, { "id": "RGD:69406", "url": "https://alliancegenome.org/gene/RGD:69406#orthology", "database": "AGR" }, { "id": "MGI:1349390", "url": "https://alliancegenome.org/gene/MGI:1349390#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-030131-8115", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-030131-8115#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9JKS6-1", "protein_name": "Protein piccolo", "gene_name": "Pclo", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGNEASLEGEGLPEGLAAAAGAGGSGSALHPGIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVPPAAAESPSMHRKQELDSSQAPQQPGKPPDPGRPTQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDFKEEYKSSMMPGFFSDVNPLSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKSEGMAKPPLQQPSPKPIPKQQGQVKEVIQQDSSPKSVSSQQAEKVKPQAPGTGKPSQQSPAQTPAQQASPGKPVAQQPGSAKATVQQPGPAKSPAQPAGTGKSPAQPPAKTPGQQAGLEKTSSSQQPGPKSLAQTPGHGKFPLGPVKSPAQQPGTAKHPAQQPGPQTAAKVPGPTKTPAQQSGPGKTPAQQPGPTKPSPQQPIPAKPQPQQPVATKTQPQQSAPAKPQPQQPAPAKPQPQQPTPAKPQPQPPTPAKPQPQPPTATKPQPQPPTATKPHHQQPGLAKPSAQQPTKSISQTVTGRPLQPPPTSAAQTPAQGLSKTICPLCNTTELLLHIPEKANFNTCTECQSTVCSLCGFNPNPHLTEIKEWLCLNCQMQRALGGDLAAAIPSSPQPTPKAATAPTATASKSPVPSQQASPKKEPPSKQDSPKALESKKPPEPKKPPEPKKPPEPKKPPPLVKQPTLHGPTPATAPQLPVAEALPEPAPPKEPSGPLPEQAKAPVGDVEPKQPKMTETRADIQSSSTTKPDILSSQVQSQAQVKTASPLKTDSAKPSQSFPPTGEKTTPLDSKAMPRPASDSKIISQPGPGSESKDPKHIDPIQKKDEPKKAQPKGSPKPETKPVPKGSPTPSGTRPTAGQAAPPSQQPPKPQEQSRRFSLNLGGITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQQGPHPQTGPAAPSKQAPTPSQSPAAQGPAKSTGQLPPAPAKATAVKKEAKAAAAENLESKPEQAPTAKKTEKDKKPPPAKVGKPPPSEPEKAVPAHKPDKTTKPKPACPLCRTELNLGSQEPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDMGKMPPAPSGPKASPMPAPAEPSSQKTPTGTQVKGKKKEAEGKTEAEKPVPEKETASIEKTPPMVTTDQKLEESEGKKSKVSALPEKKPSEEEKAISADKKERKPPAEEKPPLEEKKPIPVDKKLPPEAKPLSSEGEEKHEILKAHVQIPEEEPTGKVAAKAGEEEQQPDSRPEALPGATPLTLPKAGEKERAVAQPQAEGSSKDGQGERSKEKTEKEEDKSDTSSSQQPKSPQGLSDTGYSSDGISGSLGEIPSLIPSDEKDLLKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLVGEKAEKKTQPQKISPEKPQDQQKTQTASETLDITISEEEIKESQEKKVSPKKDSEQGFPSRKEHKEKPELVDDLSPRRASYDSVEDSSESENSPVVRRKRRTSIGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDEEFIRSQLKEISGVGESQKREEAKGKGKGVAGKHRRLTRKSSTSFDDDAGRRHSWHDEDDETFDESPELKFRETKSQESEELVVAGGGGLRRFKTIELNSTIADKYSSESSQKKTILYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRSHGPLLPTIEDSSEEEELREEEELLKEQEKQRELEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPAAVSLYSPTDEQSVMQKEGVQKALKSAEEMYEEMMQKPHKYKAFPAANERDEVFEKEPLYGGMLIEDYIYESLVEDTYNGSVDGSLLTRQEEQNGFMQQRGREQKVRLQEQIYDDPMQKISDLQKEFYELESLHSVVPQEDIVSSSYIIPESHEIVDLGSMVMSTSEEKKLLDADSAYEELMRRQQVQVTDGSSPVQTTIGDDMAESTLDFDRVQDASLTSSILSGASLTDSTSSATLSIPDVKITQQFSAEELEDEYVTDYTREIQDIIAHESLILTYSEPSESATSVPPSDTPSLTSSISSVCTTDSSSPVTTLDSLTTVYTEPADVMTKFKDSEEISSTYFPGSIIDYPEDISVSLDRTIMPESRTNEDRIVLSFSGMAPSVVESVGTKPERPQADTISTDLPISEKDLIKGKKETGDGIILEVLDAYKDKREESEAELTKISLPEPGLAQAPSSVTAPQIKEQHVSPHSVSGKISGQEKPTYRLPSGSLPVSTHPSKSRPFFRSSSLDISAQPPPPPPPPPPSPSTSSPPPTPPLPPATSPKPPTYPKKKLAVAATVTSTTIVTTHVDALTMVEAAAARRSNGLPATKMCAIAPPPVPPKPSQIPTGLVFTHRPEAIKPPIAPKPAVPQIPVTTQKPTDTCPKPTGLSLTSTMSLNLVTSADYNVPSPTSPLSPHSNKSSPRYSKSLMDTYVVITLPSEPGTPTDSSAAQAITSWPLGSPPKDLVSLETVFSVVPPMTSTEIPSASQPTLYTSGALGTFSVTPAVTASLFQTVPTSLTQFLPAEASKPEVSAVSSAVPSVAPRSVSIPIPPEPLALDRHQYKENGKLPLIGDAIDLRTIPKSEVKVTEKCMDLSASAMDVKRQTTANEVYRRQISAVQPSIINLSAASSLGTPVTMDSKTVAVVTCTDTTIYTTGTESQVGIEHAVTSPLQLTTSKHTELPYRKPSSQAFPTIRDEAPINLSLGPSAQAVTLAVTKPVTVPPVGVTNGWTDSTLSQGVADGEVVDLSTSKSHRTVVTMDESTSNVVTKIIEDDEKPVDLTAGRRAVCCDMVYTLPFGRSCTAQQPATTLPEDRFGYRDDHYQYDRSGPYGYRGIGGMKPSMSDTNLPEAGHFFYKSKNAFDYSGGTGAAVDLTSGRVSTGEVMDYSSKTTGPYPETRQVISGVGISTPQYSTARLTPPPGPQYGVGSVLRSSNGVVYSSVATPIPSTFAITTQPGSIFSTTVRDLSGIPTTDAMTSLSALHQSQPMPRSYFITTGASETDIAVTGIDINASLQTITMETLPAETMDSVPTLTTASEVFSEVVGEESTLLIVPDEDKQQQQLDLERELLELEKIKQQRFAEELEWERQEIQRFREQEKIMVQKKLEELQSMKQHLLYQQEEERQAQFMMRQETLAQQQLQLEQIQQLQQQLHQQLEEQKLRQIYQYNYDPSGTSSPQTTTEQAILEGQYAATEGSQFWATEDATTTASTVVAIEIPQSQGWYTVQSDGVTQYIAPPGILSTVSEIPLTDVVVKEEKQPKKRSSGAKVRGQYDEMGESVADDPRNLKKIVDSGVQTDDEETADRSYASRRRRTKKSVDTSVQTDDEDQDEWDMPSRSRRKARTGKYGDSTAEGDKTKPLSKVSSVAVQTVAEISVQTEPVGTIRTPSIRARVDAKVEIIKHISAPEKTYKGGSLGCQTETDSDTQSPPYLGATSPPKDKKRPTPLEIGYSSSHLRADPTVQLAPSPPKSPKVLYSPISPLSPGNALEPAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRAPFQYSEGFTTKGSQTMTASGTQKKVKRTLPNPPPEEVSTGTQSTYSTMGTASRRRMCRTNTMARAKILQDIDRELDLVERESAKLRKKQAELDEEEKEIDAKLRYLEMGINRRKEALLKEREKRERAYLQGVAEDRDYMSDSEVSSTRPSRVESQHGVERPRTAPQTEFSQFIPPQTQTEAQLVPPTSPYTQYQYSSPALPTQAPTPYTQQSHFQQQTLYHQQVSPYQTQPTFQAVATMSFTPQAQPTPTPQPSYQLPSQMMVIQQKPRQTTLYLEPKITSNYEVIRNQPLMIAPVSTDNTYAVSHLGSKYNSLDLRIGLEERSSMAGSPISSISADSFYADIDHHTSRNYVLIDDIGDITKGTAALSTVFSLHEKDLSKTDRLLRTTETRRSQEVTDFLAPLQTSSRLHSYVKADEDPMEDPYELKLLKHQIKQEFRRGTESLDHLAGLSHYYHADTSYRHFPKSEKYSISRLTLEKQAAKQLPAAILYQKQSKHKKSLIDPKMSKFSPIQESRDLEPDYPTYMSSGTSSIGGISSRARLLQDDITFGLRKNITDQQKFMGSSLGSGLGTLGNTIRSALQDEADKPYSSGSRSRPSSRPSSVYGLDLSIKRDSSSSSLRLKAQEAEALDVSFGHSSSSARTKPTSLPISQSRGRIPIVAQSSEEESPLSPVGQPMGMARAAAGPLPPISADTRDQFGSSHSLPEVQQHMREESRTRGYDRDIAFIMDDFQHAMSDSEAYHLRREETDWFDKPRESRLENGHGLDRKLPERLVHSRPLSQHQEQILQMNGKTIHYIFPHARVKITRDFKDHTGSGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGESAEHTGPLMEGMQVLEWNGVPLTSKTYEEVQSIINQQSGEAEICVRLDLNMLSDSENPQHLELHEPPKVDKAKSPGVDPKQLAAELQKVSLQQSPLVMSSVVEKGSHAHSGPTSAGSSSVPSPGQPGSPSVSKKKHSSTKPTDGPKAASHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEYKRRTKYVQKSLNPEWNQTVIYKSISMEQLMKKTLEVTVWDYDRFSSNDFLGEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKSHSSQNSQQSPKPSVIKSRSHGIFPDPSKDMQVPTIEKSHSSPGSSKSSSEGHLRSHGPSRSQSKTSVAQTHLEDAGVAIAAAEAAVQQLRIQPTKPTNHRPAESSVSTGSSGSSVGSGYSVDSEGSSCVAGEPNLLPIPRIGKMGQNGQDPVKQPGMGATDTEGKTQVMGEIKLALKKEMKTDGEQLIVEILQCRNITYKFKSPDHLPDLYVKLYVINISTQKKVIKKKTRVCRHDREPSFNETFRFSLSPAGHSLQILLFSNGGKFMKKTLIGEACIWLDKVDLRKRIVNWHKLLVSPTQTH", "length": 5085 }, "evidence": [ { "id": "HGNC:13406", "url": "https://alliancegenome.org/gene/HGNC:13406#orthology", "database": "AGR" }, { "id": "RGD:69406", "url": "https://alliancegenome.org/gene/RGD:69406#orthology", "database": "AGR" }, { "id": "MGI:1349390", "url": "https://alliancegenome.org/gene/MGI:1349390#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-030131-8115", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-030131-8115#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-030131-8100", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-030131-8100#orthology", "database": "AGR" }, { "id": "Q9Y6V0", "url": "https://omabrowser.org/oma/group/Q9Y6V0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9QYX7-1", "protein_name": "Protein piccolo", "gene_name": "Pclo", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGNEASLEGEGLPEGLAAAAGGAGGSGSALHPGIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVPAAAAESPSMHRKQELDSSQAPQQPGKPPDPGRPPQHGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDFKEEYKSSMMPGFFSDVNPLSAVSSVVNKFNPFDLISDSEAVQEETTKKQKVAQKDQGKSEGITKPSLQQPSPKLIPKQQGPGKEVIPQDIPSKSVSSQQAEKTKPQAPGTAKPSQQSPAQTPAQQAKPVAQQPGPAKATVQQPGPAKSPAQPAGTGKSPAQPPVTAKPPAQQAGLEKTSLQQPGPKSLAQTPGQGKVPPGPAKSPAQQPGTAKLPAQQPGPQTAAKVPGPTKTPAQLSGPGKTPAQQPGPTKPSPQQPIPAKPQPQQPVATKPQPQQPAPAKPQPQHPTPAKPQPQHPTPAKPQPQQPTPAKPQPQQPTPAKPQPQQPTPAKPQPQHPTPAKPQPQQPGLGKPSAQQPSKSISQTVTGRPLQAPPTSAAQAPAQGLSKTICPLCNTTELLLHTPEKANFNTCTECQSTVCSLCGFNPNPHLTEIKEWLCLNCQMQRALGGELAAIPSSPQPTPKAASVQPATASKSPVPSQQASPKKELPSKQDSPKAPESKKPPPLVKQPTLHGPTPATAPQPPVAEALPKPAPPKKPSAALPEQAKAPVADVEPKQPKTTETLTDSPSSAAATSKPAILSSQVQAQAQVTTAPPLKTDSAKTSQSFPPTGDTITPLDSKAMPRPASDSKIVSHPGPTSESKDPVQKKEEPKKAQTKVTPKPDTKPVPKGSPTPSGTRPTTGQATPQSQQPPKPPEQSRRFSLNLGGIADAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQQAPHPQTGPAAPSKQAPPPSQTLAAQGPPKSTGPHPSAPAKTTAVKKETKGPAAENLEAKPVQAPTVKKAEKDKKPPPGKVSKPPPTEPEKAVLAQKPDKTTKPKPACPLCRTELNVGSQDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDMDKMPPASSGPKASPVPAPAEPPPQKTPTAAHAKGKKKETEVKAETEKQIPEKETPSIEKTPPAVATDQKLEESEVTKSLVSVLPEKKPSEEEKALPADKKEKKPPAAEAPPLEEKKPIPDDQKLPPDAKPSASEGEEKRDLLKAHVQIPEEGPIGKVASLACEGEQQPDTRPEDLPGATPQTLPKDRQKESRDVTQPQAEGTAKEGRGEPSKDRTEKEEDKSDTSSSQQPKSPQGLSDTGYSSDGISGSLGEIPSLIPSDEKDLLKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLVGEKAEKKTQPQKVSPEQPQDQQKTQTPSETRDISISEEEIKESQEKKVTSKKDSAQGFPSRKEHKENPELVDDLSPRRASYDSVEDSSESENSPVARRKRRTSIGSSSSEEYKQEDSQGSGEDEDFIRKQIIEMSADEDASGSEDEEFIRSQLKEIGGVTESQKREETKGKGKSPAGKHRRLTRKSSTSFDDDAGRRHSWHDEDDETFDESPELKFRETKSQESEELVVAGGGGLRRFKTIELNSTVTDKYSAESSQKKTTLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRSHGPLLPTIEDSSEEEELREEEELLKEQEKQRELEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSVMQKEGAQKALKSAEEMYEEMMHKPHKYKAFPAANERDEVFEKEPLYGGMLIEDYIYESLVEDTYNGSVDGSLLTRQDEQNGFMQQRGREQKIRLQEQIYDDPMQKITDLQKEFYELESLHSIVPQEDIVSSSYIIPESHEIVDLGSMVTSTSEEKKLLDADAAYEELMKRQQMQVTDGSSLIQTTMGDDMAESTLDFDRVQDASLTSSILSGASLTDSTSSATLSIPDVKITQHFSTEEFEDEYVTDYTREIQEIIAHESLILTYSEPSESATSVPPSDTPSLTSSISSVCTTDSSSPVTTLDSLTTVYTEPADVITKFKDSEEISSTYFPGSVIDYPEDIGVSLDRTITPESRTNADQIMISFPGIAPSITESVATKPERPQADTISTDLPISEKELIKGKKETGDGIILEVLDAYKDKREESEAELTKISLPETGLAPTPSSQTKEQPGSPHSVSGEILGQEKPTYRSPSGGLPVSTHPSKSHPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPATSPKPPTYPKRKLAAAAPVAPTAIVTAHADAIPTVEATAARRSNGLPATKICAAAPPPVPPKPSSIPTGLVFTHRPEASKPPIAPKPAVPEIPVTTQKTTDTCPKPTGLPLTSNMSLNLVTSADYKLPSPTSPLSPHSNKSSPRYSKSLMETYVVITLPSEPGTPTDSSAAQAITSWPLGSPPKDLVSLETVFSVVPPMTSTEIPSASQPTLYTSGALGTFSVTPAVTASLFQTVPTSLTQFLPAEASKPEVSAVSSAVPSVAPRSVSIPIPPEPLALDRHQYKENGKLPLIGDAIDLRTIPKSEVKVTEKCMDLSASAMDVKRQTTANEVYRRQISAVQPSIINLSAASSLGTPVTMDSKTVAVVTCTDTTIYTTGTESQVGIEHAVTSPLQLTTSKHTELQYRKPSSQAFPMIRDEAPINLSLGPSTQAVTLAVTKPVTVPPVGVTNGWTDSTISQGITDGEVVDLSTSKSHRTVVTMDESTSNVVTKIIEDEEKPVDLTAGRRAVCCDMVYKLPFGRSCTAQQPATTLPEDRFGYRDDHYQYDRSGPYGYRGIGGMKPSMSDTNLAEAGHFFYKSKNAFDYSGGTEAAVDLTSGRVSTGEVMDYSSKTTGPYPETRQVISGVGISTPQYSTARMTPPPGPQYGVGSVLRSSNGVVYSSVATPIPSTFAITTQPGSIFSTTVRDLSGIHTTDAITSLSALHQSQPMPRSYFITTGASETDISVTSIDINASLQTITMETLPAETMDSVPTLTTASEVFSEVVGEESTLLIVPDEDKQQQQLDLERELLELEKIKQQRFAEELEWERQEIQRFREQEKIMVQKKLEELQSMKQHLLYQQEEERQAQFMMRQETLAQQQLQLEQIQQLQQQLHQQLEEQKLRQIYQYNYEPSGTASPQTTTEQAILEGQYVATEGSQFWATEDATTTASTVVAIEIPQSQGWYTVQSDGVTQYIAPPGILSTVSEIPLTDVVVKEEKQPKKRSSGAKVRGQYDEMGESMADDPRNLKKIVDSGVQTDDEETADRTYASRRRRTKKSVDTSVQTDDEDQDEWDMPSRSRRKARTGKYGDSTAEGDKTKPPSKVSSVAVQTVAEISVQTEPLGTIRTPSIRARVDAKVEIIKHISAPEKTYKGGSLGCQTETDPDTQSPPYMGATSPPKDKKRPTPLEIGYSSSHLRADPTVQLAPSPPKSPKVLYSPISPLSPGHALEPAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRAPFQYSEGFTAKGSQTTSGTQKKVKRTLPNPPPEEASTGTQSTYSTMGTASRRRMCRTNTMARAKILQDIDRELDLVERESAKLRKKQAELDEEEKEIDAKLRYLEMGINRRKEALLKEREKRERAYLQGVAEDRDYMSDSEVSSTRPSRVESQHGIERPRTAPQTEFSQFIPPQTQTEAQLVPPTSPYTQYQYSSPALPTQAPTPYTQQSHFQQQTLYHQQVSPYQTQPTFQAVATMSFTPQAQPTPTPQPSYQLPSQMMVIQQKPRQTTLYLEPKITSTYEVIRNQPLMIAPVSTDNTYAVSHLGSKYNSLDLRIGLEERSSMASSPISSISADSFYADIDHHTSRNYVLIDDIGDITKGTAALSSAFSLHEKDLSKTDRLLRTTETRRSQEVTDFLAPLQTSSRLHSYVKAEEDSMEDPYELKLLKHQIKQEFRRGTESLDHLAGLSHYYHADTSYRHFPKSEKYSISRLTLEKQAAKQLPAAILYQKQSKHKKALIDPKMSKFSPIQESRDLEPDYPTYLSSSTSSIGGISSRARLLQDDITFGLRKNITDQQKFMGSSLGSGLGTLGNTIRSALQDEADKPYSSGSRSRPSSRPSSVYGLDLSIKRDSSSSSLRLKAQEAEALDVSFGHSSSSARTKPTSLPISQSRGRIPIVAQNSEEESPLSPVGQPMGMARAAAGPLPPISADTRDQFGSSHSLPEVQQHMREESRTRGYDRDIAFIMDDFQHAMSDSEAYHLRREETDWFDKPRESRLENGHGLDRKLPERLVHSRPLSQHQEQILQMNGKTMHYIFPHARIKITRDSKDHTVSGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGGSAEHSGKLIEGMQVLEWNGIPLTSKTYEEVQSIINQQSGEAEICVRLDLNMLSDSENPQHLELHEPPKVVDKAKSPGVDPKQLAAELQKVSLQQSPLVMSSVVEKGAHAHSGPTSAGSSSVPSPGQPGSPSVSKKKHGGSKPTDVSKTASHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASVEYKRRTKYVQKSLNPEWNQTVIYKSISMEQLMKKTLEVTVWDYDRFSSNDFLGEVLIDLSSTSHLDNTPRWYPLKEQTESIEHGKSHSSQNSQQSPKPSVIKSRSHGIFPDPSKDMQVPTIEKSHSSPGSSKSSSEGHLRSHGPSRSQSKTSVAQTHLEDAGAAIAAAEAAVQQLRIQPTKPTNHRPAETSVSTGSSGSSVGSGYSVDSEGSSCVAGEPNLLPIPRIGKMGQNGQDPVKQPGMGAADTEAKTQVMGEIKLALKKEMKTDGEQLIVEILQCRNITYKFKSPDHLPDLYVKIYVINIATQKKVIKKKTRVCRHDREPSFNETFRFSLSPAGHSLQILLFSNGGKFMKKTLIGEACIWLDKVDLRKRIVNWHKLLMSPTQTH", "length": 5068 }, "evidence": [ { "id": "HGNC:13406", "url": "https://alliancegenome.org/gene/HGNC:13406#orthology", "database": "AGR" }, { "id": "RGD:69406", "url": "https://alliancegenome.org/gene/RGD:69406#orthology", "database": "AGR" }, { "id": "MGI:1349390", "url": "https://alliancegenome.org/gene/MGI:1349390#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-030131-8115", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-030131-8115#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-030131-8100", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-030131-8100#orthology", "database": "AGR" }, { "id": "Q9Y6V0", "url": "https://omabrowser.org/oma/group/Q9Y6V0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ], "pmid": "" }, { "name": "GABA-ergic synapse", "id": "GO:0098982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098982", "evidence": [ { "database": "UniProtKB", "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ], "pmid": "" }, { "name": "postsynaptic density", "id": "GO:0014069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "database": "UniProtKB", "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ], "pmid": "" }, { "name": "cytoskeleton of presynaptic active zone", "id": "GO:0048788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048788", "evidence": [ { "database": "UniProtKB", "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "synaptic vesicle clustering", "id": "GO:0097091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097091", "evidence": [ { "database": "UniProtKB", "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ], "pmid": "" }, { "name": "cytoskeleton organization", "id": "GO:0007010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007010", "evidence": [ { "database": "UniProtKB", "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ], "pmid": "" }, { "name": "protein localization to synapse", "id": "GO:0035418", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035418", "evidence": [ { "database": "UniProtKB", "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ], "pmid": "" }, { "name": "presynaptic active zone assembly", "id": "GO:1904071", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904071", "evidence": [ { "database": "UniProtKB", "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ], "pmid": "" }, { "name": "synaptic vesicle exocytosis", "id": "GO:0016079", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016079", "evidence": [ { "database": "UniProtKB", "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ], "pmid": "" }, { "name": "presynaptic actin cytoskeleton organization", "id": "GO:0099140", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099140", "evidence": [ { "database": "UniProtKB", "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ], "pmid": "" }, { "name": "regulation of transport", "id": "GO:0051049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051049", "evidence": [ { "database": "UniProtKB", "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "structural constituent of presynaptic active zone", "id": "GO:0098882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098882", "evidence": [ { "database": "UniProtKB", "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ], "pmid": "" }, { "name": "calcium-dependent phospholipid binding", "id": "GO:0005544", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005544", "evidence": [ { "database": "UniProtKB", "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ], "pmid": "" }, { "name": "profilin binding", "id": "GO:0005522", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005522", "evidence": [ { "database": "UniProtKB", "id": "Q9Y6V0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1673, "end_pos": 1675, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1829, "end_pos": 1831, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1966, "end_pos": 1968, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2566, "end_pos": 2568, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2777, "end_pos": 2779, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2854, "end_pos": 2856, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3429, "end_pos": 3431, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4248, "end_pos": 4250, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4748, "end_pos": 4750, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4769, "end_pos": 4771, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5035, "end_pos": 5037, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5057, "end_pos": 5059, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5081, "end_pos": 5083, "annotation": "n_glycosylation_sequon" }, { "start_pos": 593, "end_pos": 595, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "1ujd", "pdb_chain": "a", "start_pos": 4489, "end_pos": 4592, "overlap": "1.0", "method": "NMR_Spectroscopy", "type": "experimental", "resolution": 100.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/1ujd.pdb", "url_external": "https://www.rcsb.org/structure/1ujd" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q9Y6V0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y6V0" }, { "id": "PRU00041", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00041" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2 1", "eco_id": "ECO_0000255", "start_pos": 4694, "end_pos": 4823, "start_aa": "Ile", "end_aa": "Tyr", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q9Y6V0", "database": "UniProtKB", "url": 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