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"UniProtKB", "id": "P48999", "url": "https://www.uniprot.org/uniprotkb/P48999" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "publication": [ { "title": "Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme.", "journal": "Antioxidants & redox signaling", "date": "2020", "authors": "Marbach-Breitruck E, Kutzner L, Rothe M, Gurke R, Schreiber Y, Reddanna P, Schebb NH, Stehling S, Wieler LH, Heydeck D, Kuhn H", "evidence": [ { "database": "UniProtKB", "id": "P48999", "url": "https://www.uniprot.org/uniprotkb/P48999" } ], "reference": [ { "type": "PubMed", "id": "31642348", "url": "https://glygen.org/publication/PubMed/31642348" } ] }, { "title": "Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants.", "journal": "Archives of biochemistry and biophysics", "date": "2013", "authors": "Hofheinz K, Kakularam KR, Adel S, Anton M, Polymarasetty A, Reddanna P, Kuhn H, Horn T", "evidence": [ { "database": "UniProtKB", "id": "P48999", "url": "https://www.uniprot.org/uniprotkb/P48999" } ], "reference": [ { "type": "PubMed", "id": "23246375", "url": "https://glygen.org/publication/PubMed/23246375" } ] } ], "crossref": [ { "id": "P48999", "url": "https://www.uniprot.org/uniprotkb/P48999", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "31642348", "url": "https://glygen.org/publication/PubMed/31642348", "database": "PubMed", "categories": [ "Other" ] }, { "id": "23246375", "url": "https://glygen.org/publication/PubMed/23246375", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "F", "start_aa": "F", "up_seq": "LPTDSKYDWLLAKIWVRSSD", "down_seq": "HVHQTITHLLRTHLVSEVFG", "mutagenesis": [ { "sequence_org": "F", "sequence_mut": "W", "comment": "Increases formation of (8S)-hydroperoxyicosatetraenoic acid ((8S)-HPETE). Exhibits a (8S)-lipoxygenase activity; when associated with I-425. Exhibits a (15S)-lipoxygenase activity; when associated with I-425 and M-426. Loss of arachidonate (5S)-lipoxygenase activity; when associated with G-411; I-425 and M-426. Forms 11(R)-hydroperoxyicosatetraenoic acid (11(R)-HPETE) as the major arachidonic acid oxygenation product; when associated with G-411; I-425 and M-426. Does not oxygenate arachidonic acid into 5-HETE; when associated with I-425 and M-426. Catalyzes oxygenation of arachidonic acid into a major product (15S)-HETE followed by 12-HETE and 8-HETE;when associated with I-425 and M-426. Catalyzes oxygenation of linoleic acid, gamma-linolenic acid, arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid; when associated with I-425 and M-426. Catalyzes oxygenation of anandamide to 15-OH-ANA. Knockin mice are viable, fertile, and develop normally; when associated with I-425 and M-426. Mice convert arachidonic to 15-HETE, 12-HETE, and 8-HETE; when associated with I-425 and M-426. Mice cannot synthesize pro-inflammatory leukotrienes but show significantly attenuated plasma levels of lipolytic endocannabinoids; when associated with I-425 and M-426. When aging, animals gain significantly more body weight probably due to higher levels of 13-HODE in the adipose tissue; when associated with I-425 and M-426.", "evidence": [ { "database": "UniProtKB", "id": "P48999", "url": "https://www.uniprot.org/uniprotkb/P48999" }, { "database": "PubMed", "id": "31642348", "url": "https://glygen.org/publication/PubMed/31642348" }, { "database": "PubMed", "id": "23246375", "url": "https://glygen.org/publication/PubMed/23246375" } ] } ], "all_sites": [ { "type": "mutagenesis", "site_list": [ { "start_pos": "360", "end_pos": "360" }, { "start_pos": "411", "end_pos": "411" }, { "start_pos": "425", "end_pos": "425" }, { "start_pos": "426", "end_pos": "426" }, { "start_pos": "604", "end_pos": "604" }, { "start_pos": "672", "end_pos": "672" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "272", "end_pos": "272" }, { "start_pos": "524", "end_pos": "524" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "P48999-1.411.411", "start_pos": 411, "end_pos": 411, "uniprot_canonical_ac": "P48999-1", "length": 674, "uniprot_id": "LOX5_MOUSE", "protein_name": "Polyunsaturated fatty acid 5-lipoxygenase", "refseq_ac": "NP_033792", "refseq_name": "polyunsaturated fatty acid 5-lipoxygenase", "gene_name": "Alox5", "gene_names_uniprotkb": "Alox5", "gene_names_refseq": "5-LOX; 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Forms 9-hydroperoxyicosatetraenoic acid (9-HPETE) as the major arachidonic acid oxygenation product. Loss of arachidonate (5S)-lipoxygenase activity; when associated with W-360; I-425 and M-426. Forms 11(R)-hydroperoxyicosatetraenoic acid (11(R)-HPETE) as the major arachidonic acid oxygenation product; when associated with W-360; I-425 and M-426.", "evidence": [ { "database": "UniProtKB", "id": "P48999", "url": "https://www.uniprot.org/uniprotkb/P48999" }, { "database": "PubMed", "id": "23246375", "url": "https://glygen.org/publication/PubMed/23246375" } ] } ], "all_sites": [ { "type": "mutagenesis", "site_list": [ { "start_pos": "360", "end_pos": "360" }, { "start_pos": "411", "end_pos": "411" }, { "start_pos": "425", "end_pos": "425" }, { "start_pos": "426", "end_pos": "426" }, { "start_pos": "604", "end_pos": "604" }, { "start_pos": "672", "end_pos": "672" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "272", "end_pos": "272" }, { "start_pos": "524", "end_pos": "524" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 14, "direction": "upstream", "id": "P48999-1.425.425", "categories": [ "mutagenesis_flag" ] }, { "distance": 15, "direction": "upstream", "id": "P48999-1.426.426", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "P48999-1.425.425", "start_pos": 425, "end_pos": 425, "uniprot_canonical_ac": "P48999-1", "length": 674, "uniprot_id": "LOX5_MOUSE", "protein_name": "Polyunsaturated fatty acid 5-lipoxygenase", "refseq_ac": "NP_033792", "refseq_name": "polyunsaturated fatty acid 5-lipoxygenase", "gene_name": "Alox5", "gene_names_uniprotkb": "Alox5", "gene_names_refseq": "5-LOX; 5-LO; 5LO; 5LX; Alox5; F730011J02", "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "P48999", "url": "https://www.uniprot.org/uniprotkb/P48999" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "publication": [ { "title": "Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme.", "journal": "Antioxidants & redox signaling", "date": "2020", "authors": "Marbach-Breitruck E, Kutzner L, Rothe M, Gurke R, Schreiber Y, Reddanna P, Schebb NH, Stehling S, Wieler LH, Heydeck D, Kuhn H", "evidence": [ { "database": "UniProtKB", "id": "P48999", "url": "https://www.uniprot.org/uniprotkb/P48999" } ], "reference": [ { "type": "PubMed", "id": "31642348", "url": "https://glygen.org/publication/PubMed/31642348" } ] }, { "title": "Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants.", "journal": "Archives of biochemistry and biophysics", "date": "2013", "authors": "Hofheinz K, Kakularam KR, Adel S, Anton M, Polymarasetty A, Reddanna P, Kuhn H, Horn T", "evidence": [ { "database": "UniProtKB", "id": "P48999", "url": "https://www.uniprot.org/uniprotkb/P48999" } ], "reference": [ { "type": "PubMed", "id": "23246375", "url": "https://glygen.org/publication/PubMed/23246375" } ] } ], "crossref": [ { "id": "P48999", "url": "https://www.uniprot.org/uniprotkb/P48999", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "31642348", "url": "https://glygen.org/publication/PubMed/31642348", "database": "PubMed", "categories": [ "Other" ] }, { "id": "23246375", "url": "https://glygen.org/publication/PubMed/23246375", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "A", "start_aa": "A", "up_seq": "IAINTKAREQLICEYGLFDK", "down_seq": "NATGGGGHVQMVQRAVQDLT", "mutagenesis": [ { "sequence_org": "A", "sequence_mut": "I", "comment": "Decreases arachidonate (5S)-lipoxygenase activity. Decreases arachidonate 5 lipoxygenase activity; when associated with A-604. Exhibits a (8S)-lipoxygenase activity; when associated with W-360. Exhibits a (15S)-lipoxygenase activity; when associated with W-360 and M-426. Loss of arachidonate (5S)-lipoxygenase activity; when associated with W-360; G-411 and M-426. Forms 11(R)-hydroperoxyicosatetraenoic acid (11(R)-HPETE) as the major arachidonic acid oxygenation product; when associated with W-360; G-411 and M-426. Does not oxygenate arachidonic acid into 5-HETE; when associated with I-425 and M-426. Catalyzes oxygenation of arachidonic acid into a major product (15S)-HETE followed by 12-HETE and 8-HETE; when associated with I-425 and M-426. Catalyzes oxygenation of linoleic acid, gamma-linolenic acid, arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid; when associated with I-425 and M-426. Catalyzes oxygenation of anandamide to 15-OH-ANA. Knockin mice are viable, fertile, and develop normally; when associated with I-425 and M-426. Mice convert arachidonic to 15-HETE, 12-HETE, and 8-HETE; when associated with I-425 and M-426. Mice cannot synthesize pro-inflammatory leukotrienes but show significantly attenuated plasma levels of lipolytic endocannabinoids; when associated with I-425 and M-426. When aging, animals gain significantly more body weight probably due to higher levels of 13-HODE in the adipose tissue; when associated with I-425 and M-426.", "evidence": [ { "database": "UniProtKB", "id": "P48999", "url": "https://www.uniprot.org/uniprotkb/P48999" }, { "database": "PubMed", "id": "31642348", "url": "https://glygen.org/publication/PubMed/31642348" }, { "database": "PubMed", "id": "23246375", "url": "https://glygen.org/publication/PubMed/23246375" } ] } ], "all_sites": [ { "type": "mutagenesis", "site_list": [ { "start_pos": "360", "end_pos": "360" }, { "start_pos": "411", "end_pos": "411" }, { "start_pos": "425", "end_pos": "425" }, { "start_pos": "426", "end_pos": "426" }, { "start_pos": "604", "end_pos": "604" }, { "start_pos": "672", "end_pos": "672" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "272", "end_pos": "272" }, { "start_pos": "524", "end_pos": "524" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 14, "direction": "downstream", "id": "P48999-1.411.411", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "upstream", "id": "P48999-1.426.426", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "P48999-1.426.426", "start_pos": 426, "end_pos": 426, "uniprot_canonical_ac": "P48999-1", "length": 674, "uniprot_id": "LOX5_MOUSE", "protein_name": "Polyunsaturated fatty acid 5-lipoxygenase", "refseq_ac": "NP_033792", "refseq_name": "polyunsaturated fatty acid 5-lipoxygenase", "gene_name": "Alox5", "gene_names_uniprotkb": "Alox5", "gene_names_refseq": "5-LOX; 5-LO; 5LO; 5LX; Alox5; F730011J02", "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "P48999", "url": "https://www.uniprot.org/uniprotkb/P48999" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "publication": [ { "title": "Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme.", "journal": "Antioxidants & redox signaling", "date": "2020", "authors": "Marbach-Breitruck E, Kutzner L, Rothe M, Gurke R, Schreiber Y, Reddanna P, Schebb NH, Stehling S, Wieler LH, Heydeck D, Kuhn H", "evidence": [ { "database": "UniProtKB", "id": "P48999", "url": "https://www.uniprot.org/uniprotkb/P48999" } ], "reference": [ { "type": "PubMed", "id": "31642348", "url": "https://glygen.org/publication/PubMed/31642348" } ] }, { "title": "Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants.", "journal": "Archives of biochemistry and biophysics", "date": "2013", "authors": "Hofheinz K, Kakularam KR, Adel S, Anton M, Polymarasetty A, Reddanna P, Kuhn H, Horn T", "evidence": [ { "database": "UniProtKB", "id": "P48999", "url": "https://www.uniprot.org/uniprotkb/P48999" } ], "reference": [ { "type": "PubMed", "id": "23246375", "url": "https://glygen.org/publication/PubMed/23246375" } ] } ], "crossref": [ { "id": "P48999", "url": "https://www.uniprot.org/uniprotkb/P48999", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "31642348", "url": "https://glygen.org/publication/PubMed/31642348", "database": "PubMed", "categories": [ "Other" ] }, { "id": "23246375", "url": "https://glygen.org/publication/PubMed/23246375", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "AINTKAREQLICEYGLFDKA", "down_seq": "ATGGGGHVQMVQRAVQDLTY", "mutagenesis": [ { "sequence_org": "N", "sequence_mut": "M", "comment": "Increases formation of (8S)-hydroperoxyicosatetraenoic acid ((8S)-HPETE) and (12S)-hydroperoxyicosatetraenoic acid ((12S)-HPETE). Exhibits a (15S)-lipoxygenase activity; when associated with W-360 and I-425. Loss of arachidonate (5S)-lipoxygenase activity; when associated with W-360; G-411 and I-425. Forms 11(R)-hydroperoxyicosatetraenoic acid (11(R)-HPETE) as the major arachidonic acid oxygenation product; when associated with W-360; G-411 and I-425.", "evidence": [ { "database": "UniProtKB", "id": "P48999", "url": "https://www.uniprot.org/uniprotkb/P48999" }, { "database": "PubMed", "id": "31642348", "url": "https://glygen.org/publication/PubMed/31642348" }, { "database": "PubMed", "id": "23246375", "url": "https://glygen.org/publication/PubMed/23246375" } ] } ], "all_sites": [ { "type": "mutagenesis", "site_list": [ { "start_pos": "360", "end_pos": "360" }, { "start_pos": "411", "end_pos": "411" }, { "start_pos": "425", "end_pos": "425" }, { "start_pos": "426", "end_pos": "426" }, { "start_pos": "604", "end_pos": "604" }, { "start_pos": "672", "end_pos": "672" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "272", "end_pos": "272" }, { "start_pos": "524", "end_pos": "524" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], 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