[ { "id": "Q9VHP9-1.264.264", "start_pos": 264, "end_pos": 264, "uniprot_canonical_ac": "Q9VHP9-1", "length": 1411, "uniprot_id": "Q9VHP9_DROME", "protein_name": "Centromeric protein-C, isoform A", "refseq_ac": "NP_731254", "refseq_name": "centromeric protein-C, isoform A", "gene_name": "Cenp-C", "gene_names_uniprotkb": "Cenp-C; CENP-C; CG11745; CG11746; CG31258; CLD1; CenpC; Dmel\\CG31258; Dmel_CG31258; L1; cenp-C; dCENP-C; dCenpC; l(2)SH3 157; l(3)85Aa; l(3)SH157", "gene_names_refseq": "CENP-C; CG11745; CG11746; CG31258; CLD1; Cenp-C; CenpC; Dmel\\CG31258; L1; cenp-C; dCENP-C; dCenpC; l(2)SH3 157; l(3)85Aa; l(3)SH157", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VHP9", "url": "https://www.uniprot.org/uniprotkb/Q9VHP9" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "FHKNVLQLDYSGRAPYSRPP", "down_seq": "PSSPSVAGLRRTYTMEKGPA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr264", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "264", "end_pos": "264" }, { "start_pos": "999", "end_pos": "999" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VHP9-1.999.999", "start_pos": 999, "end_pos": 999, "uniprot_canonical_ac": "Q9VHP9-1", "length": 1411, "uniprot_id": "Q9VHP9_DROME", "protein_name": "Centromeric protein-C, isoform A", "refseq_ac": "NP_731254", "refseq_name": "centromeric protein-C, isoform A", "gene_name": "Cenp-C", "gene_names_uniprotkb": "Cenp-C; CENP-C; CG11745; CG11746; CG31258; CLD1; CenpC; Dmel\\CG31258; Dmel_CG31258; L1; cenp-C; dCENP-C; dCenpC; l(2)SH3 157; l(3)85Aa; l(3)SH157", "gene_names_refseq": "CENP-C; CG11745; CG11746; CG31258; CLD1; Cenp-C; CenpC; Dmel\\CG31258; L1; cenp-C; dCENP-C; dCenpC; l(2)SH3 157; l(3)85Aa; l(3)SH157", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VHP9", "url": "https://www.uniprot.org/uniprotkb/Q9VHP9" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GEECTEKSSDVMESLRVNTP", "down_seq": "PPIDQNSDDVPSRNPSPSRT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr999", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "264", "end_pos": "264" }, { "start_pos": "999", "end_pos": "999" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VJK4-1.441.441", "start_pos": 441, "end_pos": 441, "uniprot_canonical_ac": "Q9VJK4-1", "length": 701, "uniprot_id": "Q9VJK4_DROME", "protein_name": "MADF domain-containing protein", "refseq_ac": "NP_001260503", "refseq_name": "uncharacterized protein, isoform D", "gene_name": "Dmel\\CG5953", "gene_names_uniprotkb": "Dmel\\CG5953; CG5953; Dmel_CG5953", "gene_names_refseq": "CG5953; Dmel\\CG5953", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VJK4", "url": "https://www.uniprot.org/uniprotkb/Q9VJK4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "NMHEAHKNHLLNSPAGGRSV", "down_seq": "PRQAHEQLHHHPHTQHHLQQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr441", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "441", "end_pos": "441" }, { "start_pos": "575", "end_pos": "575" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VJK4-1.575.575", "start_pos": 575, "end_pos": 575, "uniprot_canonical_ac": "Q9VJK4-1", "length": 701, "uniprot_id": "Q9VJK4_DROME", "protein_name": "MADF domain-containing protein", "refseq_ac": "NP_001260503", "refseq_name": "uncharacterized protein, isoform D", "gene_name": "Dmel\\CG5953", "gene_names_uniprotkb": "Dmel\\CG5953; CG5953; Dmel_CG5953", "gene_names_refseq": "CG5953; Dmel\\CG5953", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VJK4", "url": "https://www.uniprot.org/uniprotkb/Q9VJK4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AQAKANFGAFILPPRGSDAS", "down_seq": "PAMPLNMRKLTGAGSAGHML", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr575", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "441", "end_pos": "441" }, { "start_pos": "575", "end_pos": "575" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VC09-1.515.515", "start_pos": 515, "end_pos": 515, "uniprot_canonical_ac": "Q9VC09-1", "length": 863, "uniprot_id": "Q9VC09_DROME", "protein_name": "PID domain-containing protein", "refseq_ac": "NP_001262939", "refseq_name": "uncharacterized protein, isoform D", "gene_name": "Dmel\\CG11168", "gene_names_uniprotkb": "Dmel\\CG11168; CG11168; Dmel_CG11168", "gene_names_refseq": "CG11168; Dmel\\CG11168", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC09", "url": "https://www.uniprot.org/uniprotkb/Q9VC09" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GNGTKLRLVRHSPTPDYPPP", "down_seq": "VTEAERTIFNFMQPATLRKN", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr515", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "515", "end_pos": "515" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VGI4-1.823.823", "start_pos": 823, "end_pos": 823, "uniprot_canonical_ac": "Q9VGI4-1", "length": 1142, "uniprot_id": "Q9VGI4_DROME", "protein_name": "non-specific serine/threonine protein kinase", "refseq_ac": "NP_651986", "refseq_name": "Lk6 kinase, isoform A", "gene_name": "Lk6", "gene_names_uniprotkb": "Lk6; CG17342; CG6929; Dmel\\CG17342; Dmel_CG17342; LK6; MESR8; anon-WO0172774.84; lk6", "gene_names_refseq": "CG17342; CG6929; Dmel\\CG17342; LK6; Lk6; MESR8; MNK/LK6; anon-WO0172774.84; lk6", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VGI4", "url": "https://www.uniprot.org/uniprotkb/Q9VGI4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PEIYETANIVVNSAAVPAAS", "down_seq": "PAASATRPPTDNPEEDDSNV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr823", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "823", "end_pos": "823" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VUL4-1.228.228", "start_pos": 228, "end_pos": 228, "uniprot_canonical_ac": "Q9VUL4-1", "length": 503, "uniprot_id": "Q9VUL4_DROME", "protein_name": "DUF4789 domain-containing protein", "refseq_ac": "NP_648750", "refseq_name": "uncharacterized protein, isoform A", "gene_name": "CT21630; Dmel\\CG16959", "gene_names_uniprotkb": "CT21630; Dmel\\CG16959; CG16959; CT21630; Dmel\\CG16959; Dmel_CG16959", "gene_names_refseq": "CG16959; CT21630; Dmel\\CG16959", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VUL4", "url": "https://www.uniprot.org/uniprotkb/Q9VUL4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SFYYPAEESCYEHYTKGPCS", "down_seq": "PGHIFLPGGRCDCQRHLPHY", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr228", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "228", "end_pos": "228" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VY72-1.284.284", "start_pos": 284, "end_pos": 284, "uniprot_canonical_ac": "Q9VY72-1", "length": 1553, "uniprot_id": "Q9VY72_DROME", "protein_name": "Maternal gene required for meiosis, isoform H; Maternal gene required for meiosis, isoform I", "refseq_ac": "NP_572932", "refseq_name": "maternal gene required for meiosis, isoform I", "gene_name": "mamo", "gene_names_uniprotkb": "mamo; CG11071; CG11072; CG11075; CG11082; CG32606; CG32611; CG34346; CG44132; CG45477; CR44656; Dmel\\CG45477; Dmel_CG45477; Mamo; lincRNA.990", "gene_names_refseq": "CG11071; CG11072; CG11075; CG11082; CG32606; CG32611; CG34346; CG44132; CG45477; CR44656; Dmel\\CG45477; Mamo; lincRNA.990; mamo", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VY72", "url": "https://www.uniprot.org/uniprotkb/Q9VY72" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TSSSSSTGGQKREASDRSSP", "down_seq": "PAKRSSRMHPADKVDVAEDR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr284", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "284", "end_pos": "284" }, { "start_pos": "887", "end_pos": "887" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VY72-1.887.887", "start_pos": 887, "end_pos": 887, "uniprot_canonical_ac": "Q9VY72-1", "length": 1553, "uniprot_id": "Q9VY72_DROME", "protein_name": "Maternal gene required for meiosis, isoform H; Maternal gene required for meiosis, isoform I", "refseq_ac": "NP_572932", "refseq_name": "maternal gene required for meiosis, isoform I", "gene_name": "mamo", "gene_names_uniprotkb": "mamo; CG11071; CG11072; CG11075; CG11082; CG32606; CG32611; CG34346; CG44132; CG45477; CR44656; Dmel\\CG45477; Dmel_CG45477; Mamo; lincRNA.990", "gene_names_refseq": "CG11071; CG11072; CG11075; CG11082; CG32606; CG32611; CG34346; CG44132; CG45477; CR44656; Dmel\\CG45477; Mamo; lincRNA.990; mamo", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VY72", "url": "https://www.uniprot.org/uniprotkb/Q9VY72" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QQPQTGGATGSGVGGLGGSP", "down_seq": "AGASFNLRYPTPTAFYQQQQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr887", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "284", "end_pos": "284" }, { "start_pos": "887", "end_pos": "887" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9V9U3-1.297.297", "start_pos": 297, "end_pos": 297, "uniprot_canonical_ac": "Q9V9U3-1", "length": 489, "uniprot_id": "Q9V9U3_DROME", "protein_name": "Uncharacterized protein", "refseq_ac": "NP_651888", "refseq_name": "uncharacterized protein, isoform A", "gene_name": "1A3; anon-WO0118547.398; anon-WO0118547.745", "gene_names_uniprotkb": "1A3; anon-WO0118547.398; anon-WO0118547.745; 1A3; Anon1A3; CG1910; Dmel\\CG1910; Dmel_CG1910; anon-EST:fe1A3; anon-WO0118547.398; anon-WO0118547.745; anon1A3", "gene_names_refseq": "1A3; Anon1A3; CG1910; Dmel\\CG1910; anon-EST:fe1A3; anon-WO0118547.398; anon-WO0118547.745; anon1A3", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V9U3", "url": "https://www.uniprot.org/uniprotkb/Q9V9U3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EEHAAAVLESKEQNEPAKEP", "down_seq": "PEPMEVDGSSKGSSDTAQVD", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr297", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "297", "end_pos": "297" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VFB3-1.461.461", "start_pos": 461, "end_pos": 461, "uniprot_canonical_ac": "Q9VFB3-1", "length": 516, "uniprot_id": "Q9VFB3_DROME", "protein_name": "type I protein arginine methyltransferase", "refseq_ac": "NP_650434", "refseq_name": "arginine methyltransferase 3, isoform A", "gene_name": "Art3", "gene_names_uniprotkb": "Art3; CG6563; DART3; Dmel\\CG6563; Dmel_CG6563; PRMT3", "gene_names_refseq": "Art3; CG6563; DART3; Dmel\\CG6563; PRMT3", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VFB3", "url": "https://www.uniprot.org/uniprotkb/Q9VFB3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "YFETLFELPSPVMFSTSPSA", "down_seq": "PTHWKQTVFFIENPQVVKEG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr461", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "461", "end_pos": "461" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8IQG9-1.62.62", "start_pos": 62, "end_pos": 62, "uniprot_canonical_ac": "Q8IQG9-1", "length": 229, "uniprot_id": "KAD1_DROME", "protein_name": "Adenylate kinase 1", "refseq_ac": "NP_524038", "refseq_name": "adenylate kinase 1, isoform A", "gene_name": "Ak1", "gene_names_uniprotkb": "Ak1; Adk1; CG17146; Dak1", "gene_names_refseq": "ADK-1; AK1; Adk1; Ak1; CG17146; DAK1; Dak1; Dmel\\CG17146; adk1; bs34e10.y1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8IQG9", "url": "https://www.uniprot.org/uniprotkb/Q8IQG9" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "Q8IQG9", "url": "https://www.uniprot.org/uniprotkb/Q8IQG9", "database": "UniProtKB", "categories": [ "Protein" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "GCGKGTQCAKIVEKYGFTHL", "down_seq": "SGDLLRNEVASGSDKGRQLQ", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8IQG9", "url": "https://www.uniprot.org/uniprotkb/Q8IQG9" } ], "site_lbl": "Ser62" } ], "all_sites": [ { "type": "phosphorylation", "site_list": [ { "start_pos": "62", "end_pos": "62" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8IQK4-1.159.159", "start_pos": 159, "end_pos": 159, "uniprot_canonical_ac": "Q8IQK4-1", "length": 615, "uniprot_id": "Q8IQK4_DROME", "protein_name": "Nuclear export factor 3, isoform D; Nuclear export factor 3, isoform E", "refseq_ac": "NP_001287064", "refseq_name": "nuclear export factor 3, isoform E", "gene_name": "Nxf3", "gene_names_uniprotkb": "Nxf3; CG32135; Dmel\\CG32135; Dmel_CG32135; NXF3; nxf3", "gene_names_refseq": "CG32135; Dmel\\CG32135; NXF3; Nxf3; nxf3", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8IQK4", "url": "https://www.uniprot.org/uniprotkb/Q8IQK4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "KRLQEEVAVINTCQKIEVRV", "down_seq": "PGLPKSMMCAQITDEFTTAI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr159", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "159", "end_pos": "159" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8IQS4-1.435.435", "start_pos": 435, "end_pos": 435, "uniprot_canonical_ac": "Q8IQS4-1", "length": 564, "uniprot_id": "Q8IQS4_DROME", "protein_name": "Sulfatase N-terminal domain-containing protein", "refseq_ac": "NP_001287102", "refseq_name": "uncharacterized protein, isoform C", "gene_name": "CG5584", "gene_names_uniprotkb": "CG5584; CG32191; Dmel\\CG32191; Dmel_CG32191", "gene_names_refseq": "CG32191; CG5584; Dmel\\CG32191", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8IQS4", "url": "https://www.uniprot.org/uniprotkb/Q8IQS4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SVLTYRELDDLDPRDSRYAV", "down_seq": "VRNSATSRALSRYDLRRLTQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr435", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "435", "end_pos": "435" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8IR42-1.101.101", "start_pos": 101, "end_pos": 101, "uniprot_canonical_ac": "Q8IR42-1", "length": 827, "uniprot_id": "Q8IR42_DROME", "protein_name": "2.3.1.-; Drop dead", "refseq_ac": "NP_001033845", "refseq_name": "drop dead", "gene_name": "drd", "gene_names_uniprotkb": "drd; BcDNA:GM06434; CG32589; CG33968; CG5652; Dmel\\CG33968; Dmel_CG33968; GM06434; beltless; blt; lwf", "gene_names_refseq": "BcDNA:GM06434; CG32589; CG33968; CG5652; Dmel\\CG33968; GM06434; beltless; blt; drd; lwf", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8IR42", "url": "https://www.uniprot.org/uniprotkb/Q8IR42" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DATTTILEYQTANLSQLHAV", "down_seq": "PGNYTIHQMEQAEDDDDQVE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr101", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "101", "end_pos": "101" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8IRX5-1.147.147", "start_pos": 147, "end_pos": 147, "uniprot_canonical_ac": "Q8IRX5-1", "length": 284, "uniprot_id": "Q8IRX5_DROME", "protein_name": "Peptidase S1 domain-containing protein", "refseq_ac": "NP_726740", "refseq_name": "uncharacterized protein", "gene_name": "Dmel\\CG32808", "gene_names_uniprotkb": "Dmel\\CG32808; CG32808; Dmel_CG32808; EG:80H7.1; SP234", "gene_names_refseq": "CG32808; Dmel\\CG32808; EG:80H7.1; SP234", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8IRX5", "url": "https://www.uniprot.org/uniprotkb/Q8IRX5" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QSVALSKFVQPVRLPEPRQV", "down_seq": "PGNASAVLAGWGLNATGGVV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr147", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "147", "end_pos": "147" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9U1L6-1.517.517", "start_pos": 517, "end_pos": 517, "uniprot_canonical_ac": "Q9U1L6-1", "length": 756, "uniprot_id": "Q9U1L6_DROME", "protein_name": "Uncharacterized protein", "refseq_ac": "NP_569892", "refseq_name": "uncharacterized protein", "gene_name": "EG:BACR42I17.8", "gene_names_uniprotkb": "EG:BACR42I17.8; CG14625; Dmel\\CG14625; Dmel_CG14625", "gene_names_refseq": "CG14625; Dmel\\CG14625; EG:BACR42I17.8", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9U1L6", "url": "https://www.uniprot.org/uniprotkb/Q9U1L6" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "FDHSAALKNIEEFDLSHVVP", "down_seq": "PDRVERERERERERERDSRE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr517", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "517", "end_pos": "517" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9V3B8-1.119.119", "start_pos": 119, "end_pos": 119, "uniprot_canonical_ac": "Q9V3B8-1", "length": 469, "uniprot_id": "Q9V3B8_DROME", "protein_name": "Nervous fingers 1", "refseq_ac": "NP_524783", "refseq_name": "nervous fingers 1", "gene_name": "nerfin-1", "gene_names_uniprotkb": "nerfin-1; CG13906; Dmel\\CG13906; Dmel_CG13906; Nerfin-1; Nerfin; nerfin1; nerfin; nerf", "gene_names_refseq": "CG13906; Dmel\\CG13906; Nerfin-1; Nerfin; nerfin-1; nerfin1; nerfin; nerf", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V3B8", "url": "https://www.uniprot.org/uniprotkb/Q9V3B8" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SSSEVQGEVTKVEELPVKPP", "down_seq": "PPQSPAGKRKLSRESYDDEP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr119", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "119", "end_pos": "119" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9V3C6-1.444.444", "start_pos": 444, "end_pos": 444, "uniprot_canonical_ac": "Q9V3C6-1", "length": 505, "uniprot_id": "Q9V3C6_DROME", "protein_name": "Uncharacterized protein", "refseq_ac": "NP_001284768", "refseq_name": "uncharacterized protein, isoform C", "gene_name": "EG:BACR42I17.10", "gene_names_uniprotkb": "EG:BACR42I17.10; CG11382; Dmel\\CG11382; Dmel_CG11382", "gene_names_refseq": "CG11382; Dmel\\CG11382; EG:BACR42I17.10", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V3C6", "url": "https://www.uniprot.org/uniprotkb/Q9V3C6" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AFLGAKHESGSNSISGYDYA", "down_seq": "PSSTFLQAPSSPGYDYQAPA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr444", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "444", "end_pos": "444" }, { "start_pos": "497", "end_pos": "497" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9V3C6-1.497.497", "start_pos": 497, "end_pos": 497, "uniprot_canonical_ac": "Q9V3C6-1", "length": 505, "uniprot_id": "Q9V3C6_DROME", "protein_name": "Uncharacterized protein", "refseq_ac": "NP_001284768", "refseq_name": "uncharacterized protein, isoform C", "gene_name": "EG:BACR42I17.10", "gene_names_uniprotkb": "EG:BACR42I17.10; CG11382; Dmel\\CG11382; Dmel_CG11382", "gene_names_refseq": "CG11382; Dmel\\CG11382; EG:BACR42I17.10", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V3C6", "url": "https://www.uniprot.org/uniprotkb/Q9V3C6" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ATPIFEPEATYLPPASSYGP", "down_seq": "AASSHGYH", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr497", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "444", "end_pos": "444" }, { "start_pos": "497", "end_pos": "497" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9V3U5-1.274.274", "start_pos": 274, "end_pos": 274, "uniprot_canonical_ac": "Q9V3U5-1", "length": 287, "uniprot_id": "Q9V3U5_DROME", "protein_name": "Uncharacterized protein", "refseq_ac": "NP_609682", "refseq_name": "uncharacterized protein", "gene_name": "LP05416", "gene_names_uniprotkb": "LP05416; BG:DS00941.13; CG7916; CT23894; Dmel\\CG7916; Dmel_CG7916", "gene_names_refseq": "BG:DS00941.13; CG7916; CT23894; Dmel\\CG7916; LP05416", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V3U5", "url": "https://www.uniprot.org/uniprotkb/Q9V3U5" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GHKIWYLFSLLSATTGSCNP", "down_seq": "PAPWLAIESRKLD", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr274", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "274", "end_pos": "274" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9V3Y7-1.31.31", "start_pos": 31, "end_pos": 31, "uniprot_canonical_ac": "Q9V3Y7-1", "length": 333, "uniprot_id": "Q9V3Y7_DROME", "protein_name": "Uncharacterized protein", "refseq_ac": "NP_001285925", "refseq_name": "uncharacterized protein, isoform C", "gene_name": "BG:DS01759.2", "gene_names_uniprotkb": "BG:DS01759.2; CG15293; CT35241; Dmel\\CG15293; Dmel_CG15293; HL03474", "gene_names_refseq": "BG:DS01759.2; CG15293; CT35241; Dmel\\CG15293; HL03474", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V3Y7", "url": "https://www.uniprot.org/uniprotkb/Q9V3Y7" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VSLLLLKLKGAAATSLSAEP", "down_seq": "PELLNAAKQIGLDEVGLREM", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr31", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "31", "end_pos": "31" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9V3Z3-1.456.456", "start_pos": 456, "end_pos": 456, "uniprot_canonical_ac": "Q9V3Z3-1", "length": 553, "uniprot_id": "Q9V3Z3_DROME", "protein_name": "Meso18E, isoform A; Meso18E, isoform B; Meso18E, isoform C; Meso18E, isoform D", "refseq_ac": "NP_001162799", "refseq_name": "meso18E, isoform B", "gene_name": "meso18E", "gene_names_uniprotkb": "meso18E; CG14233; Dmel\\CG14233; Dmel_CG14233; Dmeso18E; Meso18E; Mmeso18E; anon-18DEd; eso18E; ld26007", "gene_names_refseq": "CG14233; Dmel\\CG14233; Dmeso18E; Meso18E; Mmeso18E; anon-18DEd; eso18E; ld26007; meso18E", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z3", "url": "https://www.uniprot.org/uniprotkb/Q9V3Z3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Quantitative and site-specific chemoproteomic profiling of O-GlcNAcylation in Drosophila.", "journal": "Bioorganic & medicinal chemistry", "date": "2025-04-10", "authors": "Lei Cong, Chen Zihan, Hao Yi, Huang Wanping, Chu Tianyu, Xiao Kangming, Zhang Che, Zhou Wen, Li Chenjian, Chen Xing", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9V3Z3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9V3Z3" } ], "reference": [ { "type": "PubMed", "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499" } ] } ], "crossref": [ { "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9V3Z3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9V3Z3", "database": "O-GlcNAc Database", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MNLLERTVVAIETLAVKRAL", "down_seq": "FPVNPTKENAPATARPLSPP", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr456", "evidence": [ { "id": "40245499", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40245499" }, { "id": "Q9V3Z3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9V3Z3" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "456", "end_pos": "456" }, { "start_pos": "462", "end_pos": "462" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 6, "direction": "upstream", "id": "Q9V3Z3-1.462.462", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9V3Z3-1.462.462", "start_pos": 462, "end_pos": 462, "uniprot_canonical_ac": "Q9V3Z3-1", "length": 553, "uniprot_id": "Q9V3Z3_DROME", "protein_name": "Meso18E, isoform A; Meso18E, isoform B; Meso18E, isoform C; Meso18E, isoform D", "refseq_ac": "NP_001162799", "refseq_name": "meso18E, isoform B", "gene_name": "meso18E", "gene_names_uniprotkb": "meso18E; CG14233; Dmel\\CG14233; Dmel_CG14233; Dmeso18E; Meso18E; Mmeso18E; anon-18DEd; eso18E; ld26007", "gene_names_refseq": "CG14233; Dmel\\CG14233; Dmeso18E; Meso18E; Mmeso18E; anon-18DEd; eso18E; ld26007; meso18E", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z3", "url": "https://www.uniprot.org/uniprotkb/Q9V3Z3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Quantitative and site-specific chemoproteomic profiling of O-GlcNAcylation in Drosophila.", "journal": "Bioorganic & medicinal chemistry", "date": "2025-04-10", "authors": "Lei Cong, Chen Zihan, Hao Yi, Huang Wanping, Chu Tianyu, Xiao Kangming, Zhang Che, Zhou Wen, Li Chenjian, Chen Xing", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9V3Z3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9V3Z3" } ], "reference": [ { "type": "PubMed", "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499" } ] } ], "crossref": [ { "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9V3Z3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9V3Z3", "database": "O-GlcNAc Database", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TVVAIETLAVKRALTFPVNP", "down_seq": "KENAPATARPLSPPPPEAQF", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr462", "evidence": [ { "id": "40245499", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40245499" }, { "id": "Q9V3Z3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9V3Z3" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "456", "end_pos": "456" }, { "start_pos": "462", "end_pos": "462" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 6, "direction": "downstream", "id": "Q9V3Z3-1.456.456", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9V406-1.568.568", "start_pos": 568, "end_pos": 568, "uniprot_canonical_ac": "Q9V406-1", "length": 631, "uniprot_id": "Q9V406_DROME", "protein_name": "Cropped, isoform A; Cropped, isoform B", "refseq_ac": "NP_001285976", "refseq_name": "cropped, isoform B", "gene_name": "crp", "gene_names_uniprotkb": "crp; 35F(AT)[[17]]; AP-4; AP4; BG:DS02740.3; CG7664; CRP; Crp; Dmel\\CG7664; Dmel_CG7664; MS:35F.AT17; bHLHe63; dAP-4; l(2)00232; l(2)35Fd; l(2)SH1614; l(2)SH2 1614; l(2)k00809; l(2)k03505", "gene_names_refseq": "35F(AT)[[17]]; AP-4; AP4; BG:DS02740.3; CG7664; CRP; Crp; Dmel\\CG7664; MS:35F.AT17; bHLHe63; crp; dAP-4; l(2)00232; l(2)35Fd; l(2)SH1614; l(2)SH2 1614; l(2)k00809; l(2)k03505", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V406", "url": "https://www.uniprot.org/uniprotkb/Q9V406" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AKTAKDSGGLVSTSTSSTAV", "down_seq": "PTAIFKVQTTGGHGNGSHLP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr568", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "568", "end_pos": "568" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9V4B8-1.0.0", "start_pos": 0, "end_pos": 0, "uniprot_canonical_ac": "Q9V4B8-1", "length": 917, "uniprot_id": "Q9V4B8_DROME", "protein_name": "EGF-like domain-containing protein", "refseq_ac": "NP_001284712", "refseq_name": "uncharacterized protein, isoform C", "gene_name": "CT7856", "gene_names_uniprotkb": "CT7856; CG10323; CG11288; CG31999; CT31491; Dmel\\CG31999; Dmel_CG31999", "gene_names_refseq": "CG10323; CG11288; CG31999; CT31491; CT7856; Dmel\\CG31999", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V4B8", "url": "https://www.uniprot.org/uniprotkb/Q9V4B8" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Drosophila O-GlcNAcase Mutants Reveal an Expanded Glycoproteome and Novel Growth and Longevity Phenotypes.", "journal": "Cells", "date": "2021", "authors": "Akan I, Halim A, Vakhrushev SY, Clausen H, Hanover JA", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9V4B8", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9V4B8" } ], "reference": [ { "type": "PubMed", "id": "33925313", "url": "https://glygen.org/publication/PubMed/33925313" } ] } ], "crossref": [ { "id": "33925313", "url": "https://glygen.org/publication/PubMed/33925313", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9V4B8", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9V4B8", "database": "O-GlcNAc Database", "categories": [ "Other" ] } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "evidence": [ { "id": "33925313", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33925313" }, { "id": "Q9V4B8", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9V4B8" } ] } ], "all_sites": [], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9V9N4-1.139.139", "start_pos": 139, "end_pos": 139, "uniprot_canonical_ac": "Q9V9N4-1", "length": 561, "uniprot_id": "CLAMP_DROME", "protein_name": "Transcription factor Clamp", "refseq_ac": "NP_001014498", "refseq_name": "Chromatin-linked adaptor for MSL proteins, isoform B", "gene_name": "Clamp", "gene_names_uniprotkb": "Clamp; CG1832", "gene_names_refseq": "CG1832; CLAMP; Clamp; Dmel\\CG1832; clamp", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V9N4", "url": "https://www.uniprot.org/uniprotkb/Q9V9N4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Structural basis for interaction between CLAMP and MSL2 proteins involved in the specific recruitment of the dosage compensation complex in Drosophila.", "journal": "Nucleic acids research", "date": "2022-06-24", "authors": "Tikhonova Evgeniya, Mariasina Sofia, Efimov Sergey, Polshakov Vladimir, Maksimenko Oksana, Georgiev Pavel, Bonchuk Artem", "evidence": [ { "database": "UniProtKB", "id": "Q9V9N4", "url": "https://www.uniprot.org/uniprotkb/Q9V9N4" } ], "reference": [ { "type": "PubMed", "id": "35648444", "url": "https://glygen.org/publication/PubMed/35648444" } ] } ], "crossref": [ { "id": "Q9V9N4", "url": "https://www.uniprot.org/uniprotkb/Q9V9N4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "35648444", "url": "https://glygen.org/publication/PubMed/35648444", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "L", "start_aa": "L", "up_seq": "ANTISNISFKCDVCSDMFPH", "down_seq": "ALLNAHKRMHTDGEQQQQQQ", "mutagenesis": [ { "sequence_org": "L", "sequence_mut": "A", "comment": "Impaired interaction with msl-2.", "evidence": [ { "database": "UniProtKB", "id": "Q9V9N4", "url": "https://www.uniprot.org/uniprotkb/Q9V9N4" }, { "database": "PubMed", "id": "35648444", "url": "https://glygen.org/publication/PubMed/35648444" } ] } ], "all_sites": [ { "type": "mutagenesis", "site_list": [ { "start_pos": "139", "end_pos": "139" }, { "start_pos": "146", "end_pos": "146" }, { "start_pos": "147", "end_pos": "147" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 7, "direction": "upstream", "id": "Q9V9N4-1.146.146", "categories": [ "mutagenesis_flag" ] }, { "distance": 8, "direction": "upstream", "id": "Q9V9N4-1.147.147", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9V9N4-1.146.146", "start_pos": 146, "end_pos": 146, "uniprot_canonical_ac": "Q9V9N4-1", "length": 561, "uniprot_id": "CLAMP_DROME", "protein_name": "Transcription factor Clamp", "refseq_ac": "NP_001014498", "refseq_name": "Chromatin-linked adaptor for MSL proteins, isoform B", "gene_name": "Clamp", "gene_names_uniprotkb": "Clamp; CG1832", "gene_names_refseq": "CG1832; CLAMP; Clamp; Dmel\\CG1832; clamp", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V9N4", "url": "https://www.uniprot.org/uniprotkb/Q9V9N4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Structural basis for interaction between CLAMP and MSL2 proteins involved in the specific recruitment of the dosage compensation complex in Drosophila.", "journal": "Nucleic acids research", "date": "2022-06-24", "authors": "Tikhonova Evgeniya, Mariasina Sofia, Efimov Sergey, Polshakov Vladimir, Maksimenko Oksana, Georgiev Pavel, Bonchuk Artem", "evidence": [ { "database": "UniProtKB", "id": "Q9V9N4", "url": "https://www.uniprot.org/uniprotkb/Q9V9N4" } ], "reference": [ { "type": "PubMed", "id": "35648444", "url": "https://glygen.org/publication/PubMed/35648444" } ] } ], "crossref": [ { "id": "Q9V9N4", "url": "https://www.uniprot.org/uniprotkb/Q9V9N4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "35648444", "url": "https://glygen.org/publication/PubMed/35648444", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "SFKCDVCSDMFPHLALLNAH", "down_seq": "RMHTDGEQQQQQQHNAQAGG", "mutagenesis": [ { "sequence_org": "K", "sequence_mut": "E", "comment": "Abolished interaction with msl-2.", "evidence": [ { "database": "UniProtKB", "id": "Q9V9N4", "url": "https://www.uniprot.org/uniprotkb/Q9V9N4" }, { "database": "PubMed", "id": "35648444", "url": "https://glygen.org/publication/PubMed/35648444" } ] } ], "all_sites": [ { "type": "mutagenesis", "site_list": [ { "start_pos": "139", "end_pos": "139" }, { "start_pos": "146", "end_pos": "146" }, { "start_pos": "147", "end_pos": "147" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 7, "direction": "downstream", "id": "Q9V9N4-1.139.139", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "upstream", "id": "Q9V9N4-1.147.147", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9V9N4-1.147.147", "start_pos": 147, "end_pos": 147, "uniprot_canonical_ac": "Q9V9N4-1", "length": 561, "uniprot_id": "CLAMP_DROME", "protein_name": "Transcription factor Clamp", "refseq_ac": "NP_001014498", "refseq_name": "Chromatin-linked adaptor for MSL proteins, isoform B", "gene_name": "Clamp", "gene_names_uniprotkb": "Clamp; CG1832", "gene_names_refseq": "CG1832; CLAMP; Clamp; Dmel\\CG1832; clamp", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V9N4", "url": "https://www.uniprot.org/uniprotkb/Q9V9N4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Structural basis for interaction between CLAMP and MSL2 proteins involved in the specific recruitment of the dosage compensation complex in Drosophila.", "journal": "Nucleic acids research", "date": "2022-06-24", "authors": "Tikhonova Evgeniya, Mariasina Sofia, Efimov Sergey, Polshakov Vladimir, Maksimenko Oksana, Georgiev Pavel, Bonchuk Artem", "evidence": [ { "database": "UniProtKB", "id": "Q9V9N4", "url": "https://www.uniprot.org/uniprotkb/Q9V9N4" } ], "reference": [ { "type": "PubMed", "id": "35648444", "url": "https://glygen.org/publication/PubMed/35648444" } ] } ], "crossref": [ { "id": "Q9V9N4", "url": "https://www.uniprot.org/uniprotkb/Q9V9N4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "35648444", "url": "https://glygen.org/publication/PubMed/35648444", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "FKCDVCSDMFPHLALLNAHK", "down_seq": "MHTDGEQQQQQQHNAQAGGD", "mutagenesis": [ { "sequence_org": "R", "sequence_mut": "E", "comment": "Does not affect interaction with msl-2.", "evidence": [ { "database": "UniProtKB", "id": "Q9V9N4", "url": "https://www.uniprot.org/uniprotkb/Q9V9N4" }, { "database": "PubMed", "id": "35648444", "url": "https://glygen.org/publication/PubMed/35648444" } ] } ], "all_sites": [ { "type": "mutagenesis", "site_list": [ { "start_pos": "139", "end_pos": "139" }, { "start_pos": "146", "end_pos": "146" }, { "start_pos": "147", "end_pos": "147" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 8, "direction": "downstream", "id": "Q9V9N4-1.139.139", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "downstream", "id": "Q9V9N4-1.146.146", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9V9U9-1.24.24", "start_pos": 24, "end_pos": 24, "uniprot_canonical_ac": "Q9V9U9-1", "length": 207, "uniprot_id": "Q9V9U9_DROME", "protein_name": "Nucleolar protein 16", "refseq_ac": "NP_651884", "refseq_name": "uncharacterized protein", "gene_name": "BcDNA:RE07994", "gene_names_uniprotkb": "BcDNA:RE07994; CG11563; Dmel\\CG11563; Dmel_CG11563", "gene_names_refseq": "BcDNA:RE07994; CG11563; Dmel\\CG11563", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V9U9", "url": "https://www.uniprot.org/uniprotkb/Q9V9U9" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Quantitative and site-specific chemoproteomic profiling of O-GlcNAcylation in Drosophila.", "journal": "Bioorganic & medicinal chemistry", "date": "2025-04-10", "authors": "Lei Cong, Chen Zihan, Hao Yi, Huang Wanping, Chu Tianyu, Xiao Kangming, Zhang Che, Zhou Wen, Li Chenjian, Chen Xing", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9V9U9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9V9U9" } ], "reference": [ { "type": "PubMed", "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499" } ] } ], "crossref": [ { "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9V9U9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9V9U9", "database": "O-GlcNAc Database", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RKNHARKRYRYNVNRKTMNK", "down_seq": "RSSTGKIKDPRMKKMWMEDQ", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr24", "evidence": [ { "id": "40245499", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40245499" }, { "id": "Q9V9U9", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9V9U9" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "24", "end_pos": "24" }, { "start_pos": "28", "end_pos": "28" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "upstream", "id": "Q9V9U9-1.28.28", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9V9U9-1.28.28", "start_pos": 28, "end_pos": 28, "uniprot_canonical_ac": "Q9V9U9-1", "length": 207, "uniprot_id": "Q9V9U9_DROME", "protein_name": "Nucleolar protein 16", "refseq_ac": "NP_651884", "refseq_name": "uncharacterized protein", "gene_name": "BcDNA:RE07994", "gene_names_uniprotkb": "BcDNA:RE07994; CG11563; Dmel\\CG11563; Dmel_CG11563", "gene_names_refseq": "BcDNA:RE07994; CG11563; Dmel\\CG11563", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V9U9", "url": "https://www.uniprot.org/uniprotkb/Q9V9U9" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Quantitative and site-specific chemoproteomic profiling of O-GlcNAcylation in Drosophila.", "journal": "Bioorganic & medicinal chemistry", "date": "2025-04-10", "authors": "Lei Cong, Chen Zihan, Hao Yi, Huang Wanping, Chu Tianyu, Xiao Kangming, Zhang Che, Zhou Wen, Li Chenjian, Chen Xing", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9V9U9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9V9U9" } ], "reference": [ { "type": "PubMed", "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499" } ] } ], "crossref": [ { "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9V9U9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9V9U9", "database": "O-GlcNAc Database", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ARKRYRYNVNRKTMNKTRSS", "down_seq": "GKIKDPRMKKMWMEDQRVGT", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr28", "evidence": [ { "id": "40245499", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40245499" }, { "id": "Q9V9U9", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9V9U9" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "24", "end_pos": "24" }, { "start_pos": "28", "end_pos": "28" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "downstream", "id": "Q9V9U9-1.24.24", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9V9Z6-1.167.167", "start_pos": 167, "end_pos": 167, "uniprot_canonical_ac": "Q9V9Z6-1", "length": 628, "uniprot_id": "Q9V9Z6_DROME", "protein_name": "C2H2-type domain-containing protein", "refseq_ac": "NP_651853", "refseq_name": "uncharacterized protein, isoform A", "gene_name": "Dmel\\CG12054", "gene_names_uniprotkb": "Dmel\\CG12054; CG12054; Dmel_CG12054", "gene_names_refseq": "CG12054; Dmel\\CG12054", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V9Z6", "url": "https://www.uniprot.org/uniprotkb/Q9V9Z6" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "FSSEFIMRYGSRHSGGGSNG", "down_seq": "PGNEKPFACPVPGCKKRYKN", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr167", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "167", "end_pos": "167" }, { "start_pos": "546", "end_pos": "546" }, { "start_pos": "560", "end_pos": "560" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9V9Z6-1.546.546", "start_pos": 546, "end_pos": 546, "uniprot_canonical_ac": "Q9V9Z6-1", "length": 628, "uniprot_id": "Q9V9Z6_DROME", "protein_name": "C2H2-type domain-containing protein", "refseq_ac": "NP_651853", "refseq_name": "uncharacterized protein, isoform A", "gene_name": "Dmel\\CG12054", "gene_names_uniprotkb": "Dmel\\CG12054; CG12054; Dmel_CG12054", "gene_names_refseq": "CG12054; Dmel\\CG12054", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V9Z6", "url": "https://www.uniprot.org/uniprotkb/Q9V9Z6" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QQQQLQQQVQQQHHVLPISP", "down_seq": "SSVSGNSSKSSSPTPQQQQQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr546", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "167", "end_pos": "167" }, { "start_pos": "546", "end_pos": "546" }, { "start_pos": "560", "end_pos": "560" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 14, "direction": "upstream", "id": "Q9V9Z6-1.560.560", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9V9Z6-1.560.560", "start_pos": 560, "end_pos": 560, "uniprot_canonical_ac": "Q9V9Z6-1", "length": 628, "uniprot_id": "Q9V9Z6_DROME", "protein_name": "C2H2-type domain-containing protein", "refseq_ac": "NP_651853", "refseq_name": "uncharacterized protein, isoform A", "gene_name": "Dmel\\CG12054", "gene_names_uniprotkb": "Dmel\\CG12054; CG12054; Dmel_CG12054", "gene_names_refseq": "CG12054; Dmel\\CG12054", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V9Z6", "url": "https://www.uniprot.org/uniprotkb/Q9V9Z6" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VLPISPTSSVSGNSSKSSSP", "down_seq": "PQQQQQQLLKKGKLELIEPM", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr560", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "167", "end_pos": "167" }, { "start_pos": "546", "end_pos": "546" }, { "start_pos": "560", "end_pos": "560" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 14, "direction": "downstream", "id": "Q9V9Z6-1.546.546", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VAA9-1.194.194", "start_pos": 194, "end_pos": 194, "uniprot_canonical_ac": "Q9VAA9-1", "length": 475, "uniprot_id": "Q9VAA9_DROME", "protein_name": "JIL-1 anchoring and stabilizing protein, isoform A; JIL-1 anchoring and stabilizing protein, isoform B", "refseq_ac": "NP_001263099", "refseq_name": "JIL-1 anchoring and stabilizing protein, isoform B", "gene_name": "Jasper", "gene_names_uniprotkb": "Jasper; CG7946; Dmel\\CG7946; Dmel_CG7946; JASPer; dP75", "gene_names_refseq": "CG7946; Dmel\\CG7946; JASPer; Jasper; dP75", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VAA9", "url": "https://www.uniprot.org/uniprotkb/Q9VAA9" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RVPTEGLATAAAIPAAPAAA", "down_seq": "PTSSKKSVKKSKPTAAVTPI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr194", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "194", "end_pos": "194" }, { "start_pos": "196", "end_pos": "196" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "upstream", "id": "Q9VAA9-1.196.196", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VAA9-1.196.196", "start_pos": 196, "end_pos": 196, "uniprot_canonical_ac": "Q9VAA9-1", "length": 475, "uniprot_id": "Q9VAA9_DROME", "protein_name": "JIL-1 anchoring and stabilizing protein, isoform A; JIL-1 anchoring and stabilizing protein, isoform B", "refseq_ac": "NP_001263099", "refseq_name": "JIL-1 anchoring and stabilizing protein, isoform B", "gene_name": "Jasper", "gene_names_uniprotkb": "Jasper; CG7946; Dmel\\CG7946; Dmel_CG7946; JASPer; dP75", "gene_names_refseq": "CG7946; Dmel\\CG7946; JASPer; Jasper; dP75", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VAA9", "url": "https://www.uniprot.org/uniprotkb/Q9VAA9" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PTEGLATAAAIPAAPAAATP", "down_seq": "SSKKSVKKSKPTAAVTPIQK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr196", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "194", "end_pos": "194" }, { "start_pos": "196", "end_pos": "196" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "downstream", "id": "Q9VAA9-1.194.194", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VB05-1.175.175", "start_pos": 175, "end_pos": 175, "uniprot_canonical_ac": "Q9VB05-1", "length": 836, "uniprot_id": "Q9VB05_DROME", "protein_name": "ALG-2 interacting protein X", "refseq_ac": "NP_651582", "refseq_name": "ALG-2 interacting protein X", "gene_name": "ALiX", "gene_names_uniprotkb": "ALiX; AIP1; ALIX; Aip1; AliX; Alix; CG12876; DAIP1; Dmel\\CG12876; Dmel_CG12876; Snf7; alix", "gene_names_refseq": "AIP1; ALIX; ALiX; Aip1; AliX; Alix; CG12876; DAIP1; Dmel\\CG12876; Snf7; alix", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VB05", "url": "https://www.uniprot.org/uniprotkb/Q9VB05" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SAGIFQYLKGATPAAVPSEP", "down_seq": "PDLSQDTLTVLQALMVAQAQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr175", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "175", "end_pos": "175" }, { "start_pos": "721", "end_pos": "721" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VB05-1.721.721", "start_pos": 721, "end_pos": 721, "uniprot_canonical_ac": "Q9VB05-1", "length": 836, "uniprot_id": "Q9VB05_DROME", "protein_name": "ALG-2 interacting protein X", "refseq_ac": "NP_651582", "refseq_name": "ALG-2 interacting protein X", "gene_name": "ALiX", "gene_names_uniprotkb": "ALiX; AIP1; ALIX; Aip1; AliX; Alix; CG12876; DAIP1; Dmel\\CG12876; Dmel_CG12876; Snf7; alix", "gene_names_refseq": "AIP1; ALIX; ALiX; Aip1; AliX; Alix; CG12876; DAIP1; Dmel\\CG12876; Snf7; alix", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VB05", "url": "https://www.uniprot.org/uniprotkb/Q9VB05" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EKEELLKDLTTESSRQACPA", "down_seq": "PALPSHYASTSGSGSDIPPG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr721", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "175", "end_pos": "175" }, { "start_pos": "721", "end_pos": "721" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VB46-1.213.213", "start_pos": 213, "end_pos": 213, "uniprot_canonical_ac": "Q9VB46-1", "length": 579, "uniprot_id": "APMAP_DROME", "protein_name": "Adipocyte plasma membrane-associated protein Hemomucin", "refseq_ac": "NP_477159", "refseq_name": "hemomucin", "gene_name": "Hmu", "gene_names_uniprotkb": "Hmu; CG3373; Rbp5; SPH210; rrm5", "gene_names_refseq": "CG3373; Dmel\\CG3373; Hmu; RRM5; Rbp5; SPH210; hmu; rrm5", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VB46", "url": "https://www.uniprot.org/uniprotkb/Q9VB46" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "Q9VB46", "url": "https://www.uniprot.org/uniprotkb/Q9VB46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PRU00498", "url": "https://prosite.expasy.org/rule/PRU00498", "database": "PROSITE-ProRule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "TIEDLVFASFANPSGRLFKY", "down_seq": "RSKNVSEVLLDELAFANGLA", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn213", "evidence": [ { "id": "Q9VB46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9VB46#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "213", "end_pos": "213" }, { "start_pos": "217", "end_pos": "217" }, { "start_pos": "41", "end_pos": "41" }, { "start_pos": "532", "end_pos": "532" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "upstream", "id": "Q9VB46-1.217.217", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VB46-1.217.217", "start_pos": 217, "end_pos": 217, "uniprot_canonical_ac": "Q9VB46-1", "length": 579, "uniprot_id": "APMAP_DROME", "protein_name": "Adipocyte plasma membrane-associated protein Hemomucin", "refseq_ac": "NP_477159", "refseq_name": "hemomucin", "gene_name": "Hmu", "gene_names_uniprotkb": "Hmu; CG3373; Rbp5; SPH210; rrm5", "gene_names_refseq": "CG3373; Dmel\\CG3373; Hmu; RRM5; Rbp5; SPH210; hmu; rrm5", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VB46", "url": "https://www.uniprot.org/uniprotkb/Q9VB46" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "Q9VB46", "url": "https://www.uniprot.org/uniprotkb/Q9VB46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PRU00498", "url": "https://prosite.expasy.org/rule/PRU00498", "database": "PROSITE-ProRule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "LVFASFANPSGRLFKYNRSK", "down_seq": "VSEVLLDELAFANGLALSPN", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn217", "evidence": [ { "id": "Q9VB46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9VB46#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "213", "end_pos": "213" }, { "start_pos": "217", "end_pos": "217" }, { "start_pos": "41", "end_pos": "41" }, { "start_pos": "532", "end_pos": "532" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "downstream", "id": "Q9VB46-1.213.213", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VB46-1.41.41", "start_pos": 41, "end_pos": 41, "uniprot_canonical_ac": "Q9VB46-1", "length": 579, "uniprot_id": "APMAP_DROME", "protein_name": "Adipocyte plasma membrane-associated protein Hemomucin", "refseq_ac": "NP_477159", "refseq_name": "hemomucin", "gene_name": "Hmu", "gene_names_uniprotkb": "Hmu; CG3373; Rbp5; SPH210; rrm5", "gene_names_refseq": "CG3373; Dmel\\CG3373; Hmu; RRM5; Rbp5; SPH210; hmu; rrm5", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VB46", "url": "https://www.uniprot.org/uniprotkb/Q9VB46" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "IILMPGLPPRTTFPFKDYIV", "down_seq": "PPKDLKGALESNFHLEGAER", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr41", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "213", "end_pos": "213" }, { "start_pos": "217", "end_pos": "217" }, { "start_pos": "41", "end_pos": "41" }, { "start_pos": "532", "end_pos": "532" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VB46-1.532.532", "start_pos": 532, "end_pos": 532, "uniprot_canonical_ac": "Q9VB46-1", "length": 579, "uniprot_id": "APMAP_DROME", "protein_name": "Adipocyte plasma membrane-associated protein Hemomucin", "refseq_ac": "NP_477159", "refseq_name": "hemomucin", "gene_name": "Hmu", "gene_names_uniprotkb": "Hmu; CG3373; Rbp5; SPH210; rrm5", "gene_names_refseq": "CG3373; Dmel\\CG3373; Hmu; RRM5; Rbp5; SPH210; hmu; rrm5", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VB46", "url": "https://www.uniprot.org/uniprotkb/Q9VB46" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TTTTTTTTPKPTTTTTPTTP", "down_seq": "PEPSKPKVKRTVPEKPAPVE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr532", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "213", "end_pos": "213" }, { "start_pos": "217", "end_pos": "217" }, { "start_pos": "41", "end_pos": "41" }, { "start_pos": "532", "end_pos": "532" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VBD6-1.258.258", "start_pos": 258, "end_pos": 258, "uniprot_canonical_ac": "Q9VBD6-1", "length": 274, "uniprot_id": "Q9VBD6_DROME", "protein_name": "TweedleJ", "refseq_ac": "NP_651489", "refseq_name": "TweedleJ", "gene_name": "TwdlJ", "gene_names_uniprotkb": "TwdlJ; CG5471; Dmel\\CG5471; Dmel_CG5471; twdlJ", "gene_names_refseq": "CG5471; Dmel\\CG5471; TwdlJ; twdlJ", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VBD6", "url": "https://www.uniprot.org/uniprotkb/Q9VBD6" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "FLPASQPEATAPISSYVPPA", "down_seq": "PGSSYLPANILRRLRF", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr258", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "258", "end_pos": "258" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VBT7-1.359.359", "start_pos": 359, "end_pos": 359, "uniprot_canonical_ac": "Q9VBT7-1", "length": 422, "uniprot_id": "Q9VBT7_DROME", "protein_name": "CHK kinase-like domain-containing protein", "refseq_ac": "NP_651370", "refseq_name": "uncharacterized protein", "gene_name": "Dmel\\CG10513", "gene_names_uniprotkb": "Dmel\\CG10513; CG10513; CT29500; Dmel_CG10513; Dro2-0", "gene_names_refseq": "CG10513; CT29500; Dmel\\CG10513; Dro2-0", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VBT7", "url": "https://www.uniprot.org/uniprotkb/Q9VBT7" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "YIPTLRQFVLQLERGRFFAV", "down_seq": "VALVCQAILTNDQNADADFN", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr359", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "359", "end_pos": "359" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VC03-1.129.129", "start_pos": 129, "end_pos": 129, "uniprot_canonical_ac": "Q9VC03-1", "length": 389, "uniprot_id": "NMNA_DROME", "protein_name": "Nicotinamide-nucleotide adenylyltransferase", "refseq_ac": "NP_001262942", "refseq_name": "nicotinamide mononucleotide adenylyltransferase, isoform C", "gene_name": "Nmnat", "gene_names_uniprotkb": "Nmnat; CG13645", "gene_names_refseq": "3R4; AAL90149; CG13645; DmNMNAT; DmNmnat; Dmel\\CG13645; NMNAT; Nmnat1; NmnatB; Nmnat; dNmnat; dnmnat; nmnat", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC03", "url": "https://www.uniprot.org/uniprotkb/Q9VC03" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity.", "journal": "PLoS biology", "date": "2006-11", "authors": "Zhai R Grace, Cao Yu, Hiesinger P Robin, Zhou Yi, Mehta Sunil Q, Schulze Karen L, Verstreken Patrik, Bellen Hugo J", "evidence": [ { "database": "UniProtKB", "id": "Q9VC03", "url": "https://www.uniprot.org/uniprotkb/Q9VC03" } ], "reference": [ { "type": "PubMed", "id": "17132048", "url": "https://glygen.org/publication/PubMed/17132048" } ] }, { "title": "Nmnat exerts neuroprotective effects in dendrites and axons.", "journal": "Molecular and cellular neurosciences", "date": "2011-09", "authors": "Wen Yuhui, Parrish Jay Z, He Ruina, Zhai R Grace, Kim Michael D", "evidence": [ { "database": "UniProtKB", "id": "Q9VC03", "url": "https://www.uniprot.org/uniprotkb/Q9VC03" } ], "reference": [ { "type": "PubMed", "id": "21596138", "url": "https://glygen.org/publication/PubMed/21596138" } ] }, { "title": "NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.", "journal": "Nature", "date": "2008-04-17", "authors": "Zhai R Grace, Zhang Fan, Hiesinger P Robin, Cao Yu, Haueter Claire M, Bellen Hugo J", "evidence": [ { "database": "UniProtKB", "id": "Q9VC03", "url": "https://www.uniprot.org/uniprotkb/Q9VC03" } ], "reference": [ { "type": "PubMed", "id": "18344983", "url": "https://glygen.org/publication/PubMed/18344983" } ] } ], "crossref": [ { "id": "Q9VC03", "url": "https://www.uniprot.org/uniprotkb/Q9VC03", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "17132048", "url": "https://glygen.org/publication/PubMed/17132048", "database": "PubMed", "categories": [ "Other" ] }, { "id": "21596138", "url": "https://glygen.org/publication/PubMed/21596138", "database": "PubMed", "categories": [ "Other" ] }, { "id": "18344983", "url": "https://glygen.org/publication/PubMed/18344983", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "W", "start_aa": "W", "up_seq": "LATQSSNWIRLSDWEVHQNQ", "down_seq": "MRTQAVLQHHQNYINNHINS", "mutagenesis": [ { "sequence_org": "W", "sequence_mut": "G", "comment": "Reduces adenylyltransferase activity; probably by disrupting substrate binding. Abolishes NMN adenylyltransferase activity; when associated with A-255. Has no effect on chaperone activity or on neuronal cell dendrite maintenance; when associated with A-255.", "evidence": [ { "database": "UniProtKB", "id": "Q9VC03", "url": "https://www.uniprot.org/uniprotkb/Q9VC03" }, { "database": "PubMed", "id": "17132048", "url": "https://glygen.org/publication/PubMed/17132048" }, { "database": "PubMed", "id": "21596138", "url": "https://glygen.org/publication/PubMed/21596138" }, { "database": "PubMed", "id": "18344983", "url": "https://glygen.org/publication/PubMed/18344983" } ] } ], "all_sites": [ { "type": "mutagenesis", "site_list": [ { "start_pos": "129", "end_pos": "129" }, { "start_pos": "255", "end_pos": "255" }, { "start_pos": "380", "end_pos": "380" }, { "start_pos": "61", "end_pos": "61" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9VC03-1.255.255", "start_pos": 255, "end_pos": 255, "uniprot_canonical_ac": "Q9VC03-1", "length": 389, "uniprot_id": "NMNA_DROME", "protein_name": "Nicotinamide-nucleotide adenylyltransferase", "refseq_ac": "NP_001262942", "refseq_name": "nicotinamide mononucleotide adenylyltransferase, isoform C", "gene_name": "Nmnat", "gene_names_uniprotkb": "Nmnat; CG13645", "gene_names_refseq": "3R4; AAL90149; CG13645; DmNMNAT; DmNmnat; Dmel\\CG13645; NMNAT; Nmnat1; NmnatB; Nmnat; dNmnat; dnmnat; nmnat", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC03", "url": "https://www.uniprot.org/uniprotkb/Q9VC03" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity.", "journal": "PLoS biology", "date": "2006-11", "authors": "Zhai R Grace, Cao Yu, Hiesinger P Robin, Zhou Yi, Mehta Sunil Q, Schulze Karen L, Verstreken Patrik, Bellen Hugo J", "evidence": [ { "database": "UniProtKB", "id": "Q9VC03", "url": "https://www.uniprot.org/uniprotkb/Q9VC03" } ], "reference": [ { "type": "PubMed", "id": "17132048", "url": "https://glygen.org/publication/PubMed/17132048" } ] }, { "title": "Nmnat exerts neuroprotective effects in dendrites and axons.", "journal": "Molecular and cellular neurosciences", "date": "2011-09", "authors": "Wen Yuhui, Parrish Jay Z, He Ruina, Zhai R Grace, Kim Michael D", "evidence": [ { "database": "UniProtKB", "id": "Q9VC03", "url": "https://www.uniprot.org/uniprotkb/Q9VC03" } ], "reference": [ { "type": "PubMed", "id": "21596138", "url": "https://glygen.org/publication/PubMed/21596138" } ] }, { "title": "NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.", "journal": "Nature", "date": "2008-04-17", "authors": "Zhai R Grace, Zhang Fan, Hiesinger P Robin, Cao Yu, Haueter Claire M, Bellen Hugo J", "evidence": [ { "database": "UniProtKB", "id": "Q9VC03", "url": "https://www.uniprot.org/uniprotkb/Q9VC03" } ], "reference": [ { "type": "PubMed", "id": "18344983", "url": "https://glygen.org/publication/PubMed/18344983" } ] } ], "crossref": [ { "id": "Q9VC03", "url": "https://www.uniprot.org/uniprotkb/Q9VC03", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "17132048", "url": "https://glygen.org/publication/PubMed/17132048", "database": "PubMed", "categories": [ "Other" ] }, { "id": "21596138", "url": "https://glygen.org/publication/PubMed/21596138", "database": "PubMed", "categories": [ "Other" ] }, { "id": "18344983", "url": "https://glygen.org/publication/PubMed/18344983", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "QSNITLITNWVPNEVSSTLI", "down_seq": "RLLGRGQSVKYLLDDLVLEY", "mutagenesis": [ { "sequence_org": "R", "sequence_mut": "A", "comment": "Reduces NMN adenylyltransferase activity; probably by disrupting substrate binding. Abolishes NMN adenylyltransferase activity; when associated with G-129. Has no effect on chaperone activity or on neuronal cell dendrite maintenance; when associated with G-129.", "evidence": [ { "database": "UniProtKB", "id": "Q9VC03", "url": "https://www.uniprot.org/uniprotkb/Q9VC03" }, { "database": "PubMed", "id": "17132048", "url": "https://glygen.org/publication/PubMed/17132048" }, { "database": "PubMed", "id": "21596138", "url": "https://glygen.org/publication/PubMed/21596138" }, { "database": "PubMed", "id": "18344983", "url": "https://glygen.org/publication/PubMed/18344983" } ] } ], "all_sites": [ { "type": "mutagenesis", "site_list": [ { "start_pos": "129", "end_pos": "129" }, { "start_pos": "255", "end_pos": "255" }, { "start_pos": "380", "end_pos": "380" }, { "start_pos": "61", "end_pos": "61" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9VC03-1.380.380", "start_pos": 380, "end_pos": 380, "uniprot_canonical_ac": "Q9VC03-1", "length": 389, "uniprot_id": "NMNA_DROME", "protein_name": "Nicotinamide-nucleotide adenylyltransferase", "refseq_ac": "NP_001262942", "refseq_name": "nicotinamide mononucleotide adenylyltransferase, isoform C", "gene_name": "Nmnat", "gene_names_uniprotkb": "Nmnat; CG13645", "gene_names_refseq": "3R4; AAL90149; CG13645; DmNMNAT; DmNmnat; Dmel\\CG13645; NMNAT; Nmnat1; NmnatB; Nmnat; dNmnat; dnmnat; nmnat", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC03", "url": "https://www.uniprot.org/uniprotkb/Q9VC03" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Alternative splicing of Drosophila Nmnat functions as a switch to enhance neuroprotection under stress.", "journal": "Nature communications", "date": "2015-11-30", "authors": "Ruan Kai, Zhu Yi, Li Chong, Brazill Jennifer M, Zhai R Grace", "evidence": [ { "database": "UniProtKB", "id": "Q9VC03", "url": "https://www.uniprot.org/uniprotkb/Q9VC03" } ], "reference": [ { "type": "PubMed", "id": "26616331", "url": "https://glygen.org/publication/PubMed/26616331" } ] } ], "crossref": [ { "id": "Q9VC03", "url": "https://www.uniprot.org/uniprotkb/Q9VC03", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "26616331", "url": "https://glygen.org/publication/PubMed/26616331", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "PGQAVQVITMQADEKEESQA", "down_seq": "KQKISQVQL", "mutagenesis": [ { "sequence_org": "K", "sequence_mut": "R", "comment": "Switches localization from nuclear to cytoplasmic.", "evidence": [ { "database": "UniProtKB", "id": "Q9VC03", "url": "https://www.uniprot.org/uniprotkb/Q9VC03" }, { "database": "PubMed", "id": "26616331", "url": "https://glygen.org/publication/PubMed/26616331" } ] } ], "all_sites": [ { "type": "mutagenesis", "site_list": [ { "start_pos": "129", "end_pos": "129" }, { "start_pos": "255", "end_pos": "255" }, { "start_pos": "380", "end_pos": "380" }, { "start_pos": "61", "end_pos": "61" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9VC03-1.61.61", "start_pos": 61, "end_pos": 61, "uniprot_canonical_ac": "Q9VC03-1", "length": 389, "uniprot_id": "NMNA_DROME", "protein_name": "Nicotinamide-nucleotide adenylyltransferase", "refseq_ac": "NP_001262942", "refseq_name": "nicotinamide mononucleotide adenylyltransferase, isoform C", "gene_name": "Nmnat", "gene_names_uniprotkb": "Nmnat; CG13645", "gene_names_refseq": "3R4; AAL90149; CG13645; DmNMNAT; DmNmnat; Dmel\\CG13645; NMNAT; Nmnat1; NmnatB; Nmnat; dNmnat; dnmnat; nmnat", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC03", "url": "https://www.uniprot.org/uniprotkb/Q9VC03" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity.", "journal": "PLoS biology", "date": "2006-11", "authors": "Zhai R Grace, Cao Yu, Hiesinger P Robin, Zhou Yi, Mehta Sunil Q, Schulze Karen L, Verstreken Patrik, Bellen Hugo J", "evidence": [ { "database": "UniProtKB", "id": "Q9VC03", "url": "https://www.uniprot.org/uniprotkb/Q9VC03" } ], "reference": [ { "type": "PubMed", "id": "17132048", "url": "https://glygen.org/publication/PubMed/17132048" } ] }, { "title": "NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.", "journal": "Nature", "date": "2008-04-17", "authors": "Zhai R Grace, Zhang Fan, Hiesinger P Robin, Cao Yu, Haueter Claire M, Bellen Hugo J", "evidence": [ { "database": "UniProtKB", "id": "Q9VC03", "url": "https://www.uniprot.org/uniprotkb/Q9VC03" } ], "reference": [ { "type": "PubMed", "id": "18344983", "url": "https://glygen.org/publication/PubMed/18344983" } ] } ], "crossref": [ { "id": "Q9VC03", "url": "https://www.uniprot.org/uniprotkb/Q9VC03", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "17132048", "url": "https://glygen.org/publication/PubMed/17132048", "database": "PubMed", "categories": [ "Other" ] }, { "id": "18344983", "url": "https://glygen.org/publication/PubMed/18344983", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "H", "start_aa": "H", "up_seq": "SLLPRIAFIACGCFSPPTPM", "down_seq": "LRMFEIAKDHFEMQGTHRVV", "mutagenesis": [ { "sequence_org": "H", "sequence_mut": "A", "comment": "Abolishes adenylyltransferase activity. Has no effect on chaperone activity.", "evidence": [ { "database": "UniProtKB", "id": "Q9VC03", "url": "https://www.uniprot.org/uniprotkb/Q9VC03" }, { "database": "PubMed", "id": "17132048", "url": "https://glygen.org/publication/PubMed/17132048" }, { "database": "PubMed", "id": "18344983", "url": "https://glygen.org/publication/PubMed/18344983" } ] } ], "all_sites": [ { "type": "mutagenesis", "site_list": [ { "start_pos": "129", "end_pos": "129" }, { "start_pos": "255", "end_pos": "255" }, { "start_pos": "380", "end_pos": "380" }, { "start_pos": "61", "end_pos": "61" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9VC10-1.108.108", "start_pos": 108, "end_pos": 108, "uniprot_canonical_ac": "Q9VC10-1", "length": 536, "uniprot_id": "Q9VC10_DROME", "protein_name": "Phosphatidylinositol glycan anchor biosynthesis class S", "refseq_ac": "NP_733060", "refseq_name": "phosphatidylinositol glycan anchor biosynthesis class S", "gene_name": "PIG-S", "gene_names_uniprotkb": "PIG-S; CG13644; CG31120; CG44255; CG6031; Dmel\\CG44255; Dmel_CG44255; PIGS; sud2", "gene_names_refseq": "CG13644; CG31120; CG44255; CG6031; Dmel\\CG44255; PIG-S; PIGS; sud2", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC10", "url": "https://www.uniprot.org/uniprotkb/Q9VC10" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LQNAFSDNEIWSVEFKQLSP", "down_seq": "PMTQEAHTPAALEKLLLENH", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr108", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "108", "end_pos": "108" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VC13-1.249.249", "start_pos": 249, "end_pos": 249, "uniprot_canonical_ac": "Q9VC13-1", "length": 463, "uniprot_id": "Q9VC13_DROME", "protein_name": "Kinesin motor domain-containing protein", "refseq_ac": "NP_651309", "refseq_name": "uncharacterized protein", "gene_name": "Dmel\\CG10845", "gene_names_uniprotkb": "Dmel\\CG10845; B; CG10845; Dmel_CG10845; Klp96B", "gene_names_refseq": "CG10845; Dmel\\CG10845; KIF26A/B; Klp96B", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC13", "url": "https://www.uniprot.org/uniprotkb/Q9VC13" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GSRTVIINYADPPEGKDDPV", "down_seq": "PAPTPSSNSNASLPDEVWRR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr249", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "249", "end_pos": "249" }, { "start_pos": "253", "end_pos": "253" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "upstream", "id": "Q9VC13-1.253.253", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VC13-1.253.253", "start_pos": 253, "end_pos": 253, "uniprot_canonical_ac": "Q9VC13-1", "length": 463, "uniprot_id": "Q9VC13_DROME", "protein_name": "Kinesin motor domain-containing protein", "refseq_ac": "NP_651309", "refseq_name": "uncharacterized protein", "gene_name": "Dmel\\CG10845", "gene_names_uniprotkb": "Dmel\\CG10845; B; CG10845; Dmel_CG10845; Klp96B", "gene_names_refseq": "CG10845; Dmel\\CG10845; KIF26A/B; Klp96B", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC13", "url": "https://www.uniprot.org/uniprotkb/Q9VC13" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VIINYADPPEGKDDPVTPAP", "down_seq": "PSSNSNASLPDEVWRRLLRQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr253", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "249", "end_pos": "249" }, { "start_pos": "253", "end_pos": "253" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "downstream", "id": "Q9VC13-1.249.249", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VC23-1.311.311", "start_pos": 311, "end_pos": 311, "uniprot_canonical_ac": "Q9VC23-1", "length": 362, "uniprot_id": "Q9VC23_DROME", "protein_name": "Uncharacterized protein", "refseq_ac": "NP_651301", "refseq_name": "uncharacterized protein", "gene_name": "Dmel\\CG7016", "gene_names_uniprotkb": "Dmel\\CG7016; CG7016; Dmel_CG7016", "gene_names_refseq": "CG7016; Dmel\\CG7016", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC23", "url": "https://www.uniprot.org/uniprotkb/Q9VC23" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TLIIGTNRPPLVPPHNPDPP", "down_seq": "PTFPTWIVPEPLPKPLDELS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr311", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "311", "end_pos": "311" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VC36-1.1166.1166", "start_pos": 1166, "end_pos": 1166, "uniprot_canonical_ac": "Q9VC36-1", "length": 1654, "uniprot_id": "Q9VC36_DROME", "protein_name": "Polybromo", "refseq_ac": "NP_651288", "refseq_name": "polybromo", "gene_name": "polybromo", "gene_names_uniprotkb": "polybromo; BAF180; Bap180; CG11375; Dmel\\CG11375; Dmel_CG11375; PB; POLYBROMO; Pb; Polybromo; anon-WO0140519.158; baf180; bap180", "gene_names_refseq": "BAF180; Bap180; CG11375; Dmel\\CG11375; PB; POLYBROMO; Pb; Polybromo; anon-WO0140519.158; baf180; bap180; polybromo", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC36", "url": "https://www.uniprot.org/uniprotkb/Q9VC36" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "WEQNGKSYFKGPWLLPPSET", "down_seq": "PGLGKQFYRQELLLSTVEEV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1166", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1166", "end_pos": "1166" }, { "start_pos": "669", "end_pos": "669" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VC36-1.669.669", "start_pos": 669, "end_pos": 669, "uniprot_canonical_ac": "Q9VC36-1", "length": 1654, "uniprot_id": "Q9VC36_DROME", "protein_name": "Polybromo", "refseq_ac": "NP_651288", "refseq_name": "polybromo", "gene_name": "polybromo", "gene_names_uniprotkb": "polybromo; BAF180; Bap180; CG11375; Dmel\\CG11375; Dmel_CG11375; PB; POLYBROMO; Pb; Polybromo; anon-WO0140519.158; baf180; bap180", "gene_names_refseq": "BAF180; Bap180; CG11375; Dmel\\CG11375; PB; POLYBROMO; Pb; Polybromo; anon-WO0140519.158; baf180; bap180; polybromo", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC36", "url": "https://www.uniprot.org/uniprotkb/Q9VC36" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Quantitative and site-specific chemoproteomic profiling of O-GlcNAcylation in Drosophila.", "journal": "Bioorganic & medicinal chemistry", "date": "2025-04-10", "authors": "Lei Cong, Chen Zihan, Hao Yi, Huang Wanping, Chu Tianyu, Xiao Kangming, Zhang Che, Zhou Wen, Li Chenjian, Chen Xing", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9VC36", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VC36" } ], "reference": [ { "type": "PubMed", "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499" } ] } ], "crossref": [ { "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9VC36", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VC36", "database": "O-GlcNAc Database", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "YETVKEYQEPKGKRQLSLIF", "down_seq": "KLPSKSEYPDYYDIIREPID", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr669", "evidence": [ { "id": "40245499", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40245499" }, { "id": "Q9VC36", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VC36" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1166", "end_pos": "1166" }, { "start_pos": "669", "end_pos": "669" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9VC47-1.1005.1005", "start_pos": 1005, "end_pos": 1005, "uniprot_canonical_ac": "Q9VC47-1", "length": 1464, "uniprot_id": "TOK_DROME", "protein_name": "Protein tolkin", "refseq_ac": "NP_001287510", "refseq_name": "tolkin, isoform C", "gene_name": "tok", "gene_names_uniprotkb": "tok; CG6863; tlr-1; tlr", "gene_names_refseq": "CG6863; CT21251; Dmel\\CG6863; TLR; TOK; Tlr-1; Tlr; Tok; tldr-1; tldr1; tlr-1; tlr1; tlr; tok", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PRU00498", "url": "https://prosite.expasy.org/rule/PRU00498", "database": "PROSITE-ProRule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "ELHSDKKHCEDACGGVIEYP", "down_seq": "GTITSPSFPEMYPLLKECIW", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1005", "evidence": [ { "id": "Q9VC47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9VC47#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1005", "end_pos": "1005" }, { "start_pos": "1038", "end_pos": "1038" }, { "start_pos": "1327", "end_pos": "1327" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "321", "end_pos": "321" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "541", "end_pos": "541" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "747", "end_pos": "747" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "516", "end_pos": "516" }, { "start_pos": "519", "end_pos": "519" }, { "start_pos": "669", "end_pos": "669" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VC47-1.1038.1038", "start_pos": 1038, "end_pos": 1038, "uniprot_canonical_ac": "Q9VC47-1", "length": 1464, "uniprot_id": "TOK_DROME", "protein_name": "Protein tolkin", "refseq_ac": "NP_001287510", "refseq_name": "tolkin, isoform C", "gene_name": "tok", "gene_names_uniprotkb": "tok; CG6863; tlr-1; tlr", "gene_names_refseq": "CG6863; CT21251; Dmel\\CG6863; TLR; TOK; Tlr-1; Tlr; Tok; tldr-1; tldr1; tlr-1; tlr1; tlr; tok", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PRU00498", "url": "https://prosite.expasy.org/rule/PRU00498", "database": "PROSITE-ProRule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "PLLKECIWEIVAPPKHRISL", "down_seq": "FTHFDLEGTAHQQSDCGYDS", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1038", "evidence": [ { "id": "Q9VC47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9VC47#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1005", "end_pos": "1005" }, { "start_pos": "1038", "end_pos": "1038" }, { "start_pos": "1327", "end_pos": "1327" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "321", "end_pos": "321" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "541", "end_pos": "541" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "747", "end_pos": "747" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "516", "end_pos": "516" }, { "start_pos": "519", "end_pos": "519" }, { "start_pos": "669", "end_pos": "669" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VC47-1.1327.1327", "start_pos": 1327, "end_pos": 1327, "uniprot_canonical_ac": "Q9VC47-1", "length": 1464, "uniprot_id": "TOK_DROME", "protein_name": "Protein tolkin", "refseq_ac": "NP_001287510", "refseq_name": "tolkin, isoform C", "gene_name": "tok", "gene_names_uniprotkb": "tok; CG6863; tlr-1; tlr", "gene_names_refseq": "CG6863; CT21251; Dmel\\CG6863; TLR; TOK; Tlr-1; Tlr; Tok; tldr-1; tldr1; tlr-1; tlr1; tlr; tok", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PRU00498", "url": "https://prosite.expasy.org/rule/PRU00498", "database": "PROSITE-ProRule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "APDNSYVQLIFLTFDIESSE", "down_seq": "CTFDYVQVFSDIDDVYGQYG", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1327", "evidence": [ { "id": "Q9VC47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9VC47#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1005", "end_pos": "1005" }, { "start_pos": "1038", "end_pos": "1038" }, { "start_pos": "1327", "end_pos": "1327" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "321", "end_pos": "321" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "541", "end_pos": "541" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "747", "end_pos": "747" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "516", "end_pos": "516" }, { "start_pos": "519", "end_pos": "519" }, { "start_pos": "669", "end_pos": "669" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VC47-1.214.214", "start_pos": 214, "end_pos": 214, "uniprot_canonical_ac": "Q9VC47-1", "length": 1464, "uniprot_id": "TOK_DROME", "protein_name": "Protein tolkin", "refseq_ac": "NP_001287510", "refseq_name": "tolkin, isoform C", "gene_name": "tok", "gene_names_uniprotkb": "tok; CG6863; tlr-1; tlr", "gene_names_refseq": "CG6863; CT21251; Dmel\\CG6863; TLR; TOK; Tlr-1; Tlr; Tok; tldr-1; tldr1; tlr-1; tlr1; tlr; tok", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PRU00498", "url": "https://prosite.expasy.org/rule/PRU00498", "database": "PROSITE-ProRule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "SPVHDPPSVSGAANSGPTKF", "down_seq": "ATFQLDLEKLKQEVYHEGLQ", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn214", "evidence": [ { "id": "Q9VC47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9VC47#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1005", "end_pos": "1005" }, { "start_pos": "1038", "end_pos": "1038" }, { "start_pos": "1327", "end_pos": "1327" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "321", "end_pos": "321" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "541", "end_pos": "541" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "747", "end_pos": "747" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "516", "end_pos": "516" }, { "start_pos": "519", "end_pos": "519" }, { "start_pos": "669", "end_pos": "669" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VC47-1.321.321", "start_pos": 321, "end_pos": 321, "uniprot_canonical_ac": "Q9VC47-1", "length": 1464, "uniprot_id": "TOK_DROME", "protein_name": "Protein tolkin", "refseq_ac": "NP_001287510", "refseq_name": "tolkin, isoform C", "gene_name": "tok", "gene_names_uniprotkb": "tok; CG6863; tlr-1; tlr", "gene_names_refseq": "CG6863; CT21251; Dmel\\CG6863; TLR; TOK; Tlr-1; Tlr; Tok; tldr-1; tldr1; tlr-1; tlr1; tlr; tok", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PRU00498", "url": "https://prosite.expasy.org/rule/PRU00498", "database": "PROSITE-ProRule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "RIHTDKPARLTLAEIGPKFS", "down_seq": "KTQSLHRNVDTRKIQSDNKD", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn321", "evidence": [ { "id": "Q9VC47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9VC47#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1005", "end_pos": "1005" }, { "start_pos": "1038", "end_pos": "1038" }, { "start_pos": "1327", "end_pos": "1327" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "321", "end_pos": "321" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "541", "end_pos": "541" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "747", "end_pos": "747" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "516", "end_pos": "516" }, { "start_pos": "519", "end_pos": "519" }, { "start_pos": "669", "end_pos": "669" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VC47-1.486.486", "start_pos": 486, "end_pos": 486, "uniprot_canonical_ac": "Q9VC47-1", "length": 1464, "uniprot_id": "TOK_DROME", "protein_name": "Protein tolkin", "refseq_ac": "NP_001287510", "refseq_name": "tolkin, isoform C", "gene_name": "tok", "gene_names_uniprotkb": "tok; CG6863; tlr-1; tlr", "gene_names_refseq": "CG6863; CT21251; Dmel\\CG6863; TLR; TOK; Tlr-1; Tlr; Tok; tldr-1; tldr1; tlr-1; tlr1; tlr; tok", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PRU00498", "url": "https://prosite.expasy.org/rule/PRU00498", "database": "PROSITE-ProRule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "HHRRRGQSTTQYVNHSPPGF", "down_seq": "QSQQAQQQSVPEMDLLKAET", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn486", "evidence": [ { "id": "Q9VC47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9VC47#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1005", "end_pos": "1005" }, { "start_pos": "1038", "end_pos": "1038" }, { "start_pos": "1327", "end_pos": "1327" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "321", "end_pos": "321" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "541", "end_pos": "541" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "747", "end_pos": "747" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "516", "end_pos": "516" }, { "start_pos": "519", "end_pos": "519" }, { "start_pos": "669", "end_pos": "669" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VC47-1.541.541", "start_pos": 541, "end_pos": 541, "uniprot_canonical_ac": "Q9VC47-1", "length": 1464, "uniprot_id": "TOK_DROME", "protein_name": "Protein tolkin", "refseq_ac": "NP_001287510", "refseq_name": "tolkin, isoform C", "gene_name": "tok", "gene_names_uniprotkb": "tok; CG6863; tlr-1; tlr", "gene_names_refseq": "CG6863; CT21251; Dmel\\CG6863; TLR; TOK; Tlr-1; Tlr; Tok; tldr-1; tldr1; tlr-1; tlr1; tlr; tok", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PRU00498", "url": "https://prosite.expasy.org/rule/PRU00498", "database": "PROSITE-ProRule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "VTAKKERIWDYGVIPYEIDG", "down_seq": "FSGIHKALFKLAMRHWENST", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn541", "evidence": [ { "id": "Q9VC47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9VC47#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1005", "end_pos": "1005" }, { "start_pos": "1038", "end_pos": "1038" }, { "start_pos": "1327", "end_pos": "1327" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "321", "end_pos": "321" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "541", "end_pos": "541" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "747", "end_pos": "747" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "516", "end_pos": "516" }, { "start_pos": "519", "end_pos": "519" }, { "start_pos": "669", "end_pos": "669" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 18, "direction": "upstream", "id": "Q9VC47-1.559.559", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VC47-1.559.559", "start_pos": 559, "end_pos": 559, "uniprot_canonical_ac": "Q9VC47-1", "length": 1464, "uniprot_id": "TOK_DROME", "protein_name": "Protein tolkin", "refseq_ac": "NP_001287510", "refseq_name": "tolkin, isoform C", "gene_name": "tok", "gene_names_uniprotkb": "tok; CG6863; tlr-1; tlr", "gene_names_refseq": "CG6863; CT21251; Dmel\\CG6863; TLR; TOK; Tlr-1; Tlr; Tok; tldr-1; tldr1; tlr-1; tlr1; tlr; tok", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PRU00498", "url": "https://prosite.expasy.org/rule/PRU00498", "database": "PROSITE-ProRule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "DGNFSGIHKALFKLAMRHWE", "down_seq": "STCIKFVERDPEIHPNYIVF", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn559", "evidence": [ { "id": "Q9VC47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9VC47#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1005", "end_pos": "1005" }, { "start_pos": "1038", "end_pos": "1038" }, { "start_pos": "1327", "end_pos": "1327" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "321", "end_pos": "321" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "541", "end_pos": "541" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "747", "end_pos": "747" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "516", "end_pos": "516" }, { "start_pos": "519", "end_pos": "519" }, { "start_pos": "669", "end_pos": "669" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 18, "direction": "downstream", "id": "Q9VC47-1.541.541", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VC47-1.747.747", "start_pos": 747, "end_pos": 747, "uniprot_canonical_ac": "Q9VC47-1", "length": 1464, "uniprot_id": "TOK_DROME", "protein_name": "Protein tolkin", "refseq_ac": "NP_001287510", "refseq_name": "tolkin, isoform C", "gene_name": "tok", "gene_names_uniprotkb": "tok; CG6863; tlr-1; tlr", "gene_names_refseq": "CG6863; CT21251; Dmel\\CG6863; TLR; TOK; Tlr-1; Tlr; Tok; tldr-1; tldr1; tlr-1; tlr1; tlr; tok", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PRU00498", "url": "https://prosite.expasy.org/rule/PRU00498", "database": "PROSITE-ProRule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "FQESSGIFASPSHYTAGALS", "down_seq": "ETEHCEWRITATYGERVELK", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn747", "evidence": [ { "id": "Q9VC47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9VC47#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1005", "end_pos": "1005" }, { "start_pos": "1038", "end_pos": "1038" }, { "start_pos": "1327", "end_pos": "1327" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "321", "end_pos": "321" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "541", "end_pos": "541" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "747", "end_pos": "747" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "516", "end_pos": "516" }, { "start_pos": "519", "end_pos": "519" }, { "start_pos": "669", "end_pos": "669" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VC47-1.516.516", "start_pos": 516, "end_pos": 516, "uniprot_canonical_ac": "Q9VC47-1", "length": 1464, "uniprot_id": "TOK_DROME", "protein_name": "Protein tolkin", "refseq_ac": "NP_001287510", "refseq_name": "tolkin, isoform C", "gene_name": "tok", "gene_names_uniprotkb": "tok; CG6863; tlr-1; tlr", "gene_names_refseq": "CG6863; CT21251; Dmel\\CG6863; TLR; TOK; Tlr-1; Tlr; Tok; tldr-1; tldr1; tlr-1; tlr1; tlr; tok", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Matching catalytic activity to developmental function: tolloid-related processes Sog in order to help specify the posterior crossvein in the Drosophila wing.", "journal": "Development (Cambridge, England)", "date": "2005-06", "authors": "Serpe Mihaela, Ralston Amy, Blair Seth S, O'Connor Michael B", "evidence": [ { "database": "UniProtKB", "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47" } ], "reference": [ { "type": "PubMed", "id": "15872004", "url": "https://glygen.org/publication/PubMed/15872004" } ] } ], "crossref": [ { "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "15872004", "url": "https://glygen.org/publication/PubMed/15872004", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "VPEMDLLKAETSKDEEPLRH", "down_seq": "VARAVTAKKERIWDYGVIPY", "mutagenesis": [ { "sequence_org": "R", "sequence_mut": "A", "comment": "Abolishes propeptide cleavage and ability to cleave sog; when associated with A-519.", "evidence": [ { "database": "UniProtKB", "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47" }, { "database": "PubMed", "id": "15872004", "url": "https://glygen.org/publication/PubMed/15872004" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1005", "end_pos": "1005" }, { "start_pos": "1038", "end_pos": "1038" }, { "start_pos": "1327", "end_pos": "1327" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "321", "end_pos": "321" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "541", "end_pos": "541" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "747", "end_pos": "747" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "516", "end_pos": "516" }, { "start_pos": "519", "end_pos": "519" }, { "start_pos": "669", "end_pos": "669" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 3, "direction": "upstream", "id": "Q9VC47-1.519.519", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9VC47-1.519.519", "start_pos": 519, "end_pos": 519, "uniprot_canonical_ac": "Q9VC47-1", "length": 1464, "uniprot_id": "TOK_DROME", "protein_name": "Protein tolkin", "refseq_ac": "NP_001287510", "refseq_name": "tolkin, isoform C", "gene_name": "tok", "gene_names_uniprotkb": "tok; CG6863; tlr-1; tlr", "gene_names_refseq": "CG6863; CT21251; Dmel\\CG6863; TLR; TOK; Tlr-1; Tlr; Tok; tldr-1; tldr1; tlr-1; tlr1; tlr; tok", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Matching catalytic activity to developmental function: tolloid-related processes Sog in order to help specify the posterior crossvein in the Drosophila wing.", "journal": "Development (Cambridge, England)", "date": "2005-06", "authors": "Serpe Mihaela, Ralston Amy, Blair Seth S, O'Connor Michael B", "evidence": [ { "database": "UniProtKB", "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47" } ], "reference": [ { "type": "PubMed", "id": "15872004", "url": "https://glygen.org/publication/PubMed/15872004" } ] } ], "crossref": [ { "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "15872004", "url": "https://glygen.org/publication/PubMed/15872004", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "MDLLKAETSKDEEPLRHRVA", "down_seq": "AVTAKKERIWDYGVIPYEID", "mutagenesis": [ { "sequence_org": "R", "sequence_mut": "A", "comment": "Abolishes propeptide cleavage and ability to cleave sog; when associated with A-516.", "evidence": [ { "database": "UniProtKB", "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47" }, { "database": "PubMed", "id": "15872004", "url": "https://glygen.org/publication/PubMed/15872004" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1005", "end_pos": "1005" }, { "start_pos": "1038", "end_pos": "1038" }, { "start_pos": "1327", "end_pos": "1327" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "321", "end_pos": "321" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "541", "end_pos": "541" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "747", "end_pos": "747" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "516", "end_pos": "516" }, { "start_pos": "519", "end_pos": "519" }, { "start_pos": "669", "end_pos": "669" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 3, "direction": "downstream", "id": "Q9VC47-1.516.516", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9VC47-1.669.669", "start_pos": 669, "end_pos": 669, "uniprot_canonical_ac": "Q9VC47-1", "length": 1464, "uniprot_id": "TOK_DROME", "protein_name": "Protein tolkin", "refseq_ac": "NP_001287510", "refseq_name": "tolkin, isoform C", "gene_name": "tok", "gene_names_uniprotkb": "tok; CG6863; tlr-1; tlr", "gene_names_refseq": "CG6863; CT21251; Dmel\\CG6863; TLR; TOK; Tlr-1; Tlr; Tok; tldr-1; tldr1; tlr-1; tlr1; tlr; tok", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Matching catalytic activity to developmental function: tolloid-related processes Sog in order to help specify the posterior crossvein in the Drosophila wing.", "journal": "Development (Cambridge, England)", "date": "2005-06", "authors": "Serpe Mihaela, Ralston Amy, Blair Seth S, O'Connor Michael B", "evidence": [ { "database": "UniProtKB", "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47" } ], "reference": [ { "type": "PubMed", "id": "15872004", "url": "https://glygen.org/publication/PubMed/15872004" } ] }, { "title": "At the next stop sign turn right: the metalloprotease Tolloid-related 1 controls defasciculation of motor axons in Drosophila.", "journal": "Development (Cambridge, England)", "date": "2006-10", "authors": "Meyer Frauke, Aberle Hermann", "evidence": [ { "database": "UniProtKB", "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47" } ], "reference": [ { "type": "PubMed", "id": "16971470", "url": "https://glygen.org/publication/PubMed/16971470" } ] } ], "crossref": [ { "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "15872004", "url": "https://glygen.org/publication/PubMed/15872004", "database": "PubMed", "categories": [ "Other" ] }, { "id": "16971470", "url": "https://glygen.org/publication/PubMed/16971470", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "NFNMLSPDEVDSLGMAYDYD", "down_seq": "IMHYARNTFSKGTYLDTILP", "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "F", "comment": "Abolishes ability to cleave sog.", "evidence": [ { "database": "UniProtKB", "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47" }, { "database": "PubMed", "id": "15872004", "url": "https://glygen.org/publication/PubMed/15872004" } ] }, { "sequence_org": "S", "sequence_mut": "T", "comment": "In tlr1-I678; Absent and/or mislocalized neuromuscular junctions with misrouted motor axons.", "evidence": [ { "database": "UniProtKB", "id": "Q9VC47", "url": "https://www.uniprot.org/uniprotkb/Q9VC47" }, { "database": "PubMed", "id": "16971470", "url": "https://glygen.org/publication/PubMed/16971470" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1005", "end_pos": "1005" }, { "start_pos": "1038", "end_pos": "1038" }, { "start_pos": "1327", "end_pos": "1327" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "321", "end_pos": "321" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "541", "end_pos": "541" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "747", "end_pos": "747" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "516", "end_pos": "516" }, { "start_pos": "519", "end_pos": "519" }, { "start_pos": "669", "end_pos": "669" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9VCC9-1.279.279", "start_pos": 279, "end_pos": 279, "uniprot_canonical_ac": "Q9VCC9-1", "length": 1100, "uniprot_id": "Q9VCC9_DROME", "protein_name": "Tsc1", "refseq_ac": "NP_477415", "refseq_name": "Tsc1", "gene_name": "Tsc1", "gene_names_uniprotkb": "Tsc1; CG6147; Dmel\\CG6147; Dmel_CG6147; TSC1; TSC; TsC1; Tsc; dTSC-1; dTSC1; dTSC; dTsc1; dtsc1; rocky; tSC1; tsc1", "gene_names_refseq": "CG6147; Dmel\\CG6147; TSC1; TSC; TsC1; Tsc1; Tsc; dTSC-1; dTSC1; dTSC; dTsc1; dtsc1; rocky; tSC1; tsc1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VCC9", "url": "https://www.uniprot.org/uniprotkb/Q9VCC9" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SLPVLLPETSNEDGSYAYPM", "down_seq": "PGYSRMTSNTSNTDYSYQLR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr279", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "279", "end_pos": "279" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VCV3-1.126.126", "start_pos": 126, "end_pos": 126, "uniprot_canonical_ac": "Q9VCV3-1", "length": 398, "uniprot_id": "Q9VCV3_DROME", "protein_name": "Ring finger protein 220", "refseq_ac": "NP_651088", "refseq_name": "ring finger protein 220", "gene_name": "Rnf220", "gene_names_uniprotkb": "Rnf220; CG4813; Dmel\\CG4813; Dmel_CG4813; RNF220", "gene_names_refseq": "CG4813; Dmel\\CG4813; RNF220", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VCV3", "url": "https://www.uniprot.org/uniprotkb/Q9VCV3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PAPPATVNPTVAAAPPPAAA", "down_seq": "PSVAAAESSQPTCPVCNHNF", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr126", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "126", "end_pos": "126" }, { "start_pos": "57", "end_pos": "57" }, { "start_pos": "62", "end_pos": "62" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VCV3-1.57.57", "start_pos": 57, "end_pos": 57, "uniprot_canonical_ac": "Q9VCV3-1", "length": 398, "uniprot_id": "Q9VCV3_DROME", "protein_name": "Ring finger protein 220", "refseq_ac": "NP_651088", "refseq_name": "ring finger protein 220", "gene_name": "Rnf220", "gene_names_uniprotkb": "Rnf220; CG4813; Dmel\\CG4813; Dmel_CG4813; RNF220", "gene_names_refseq": "CG4813; Dmel\\CG4813; RNF220", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VCV3", "url": "https://www.uniprot.org/uniprotkb/Q9VCV3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QVADHCQVEMERLHNPISAV", "down_seq": "PPTPTSGATASEESGSVSGG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr57", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "126", "end_pos": "126" }, { "start_pos": "57", "end_pos": "57" }, { "start_pos": "62", "end_pos": "62" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 5, "direction": "upstream", "id": "Q9VCV3-1.62.62", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VCV3-1.62.62", "start_pos": 62, "end_pos": 62, "uniprot_canonical_ac": "Q9VCV3-1", "length": 398, "uniprot_id": "Q9VCV3_DROME", "protein_name": "Ring finger protein 220", "refseq_ac": "NP_651088", "refseq_name": "ring finger protein 220", "gene_name": "Rnf220", "gene_names_uniprotkb": "Rnf220; CG4813; Dmel\\CG4813; Dmel_CG4813; RNF220", "gene_names_refseq": "CG4813; Dmel\\CG4813; RNF220", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VCV3", "url": "https://www.uniprot.org/uniprotkb/Q9VCV3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "CQVEMERLHNPISAVTPPTP", "down_seq": "SGATASEESGSVSGGRQPWS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr62", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "126", "end_pos": "126" }, { "start_pos": "57", "end_pos": "57" }, { "start_pos": "62", "end_pos": "62" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 5, "direction": "downstream", "id": "Q9VCV3-1.57.57", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VDD0-1.163.163", "start_pos": 163, "end_pos": 163, "uniprot_canonical_ac": "Q9VDD0-1", "length": 393, "uniprot_id": "Q9VDD0_DROME", "protein_name": "Protein-lysine N-trimethyltransferase SMYD5", "refseq_ac": "NP_650955", "refseq_name": "SET and MYND domain containing, class 5", "gene_name": "Smyd5", "gene_names_uniprotkb": "Smyd5; CG3353; Dmel\\CG3353; Dmel_CG3353", "gene_names_refseq": "CG3353; Dmel\\CG3353; Smyd5", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VDD0", "url": "https://www.uniprot.org/uniprotkb/Q9VDD0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Quantitative and site-specific chemoproteomic profiling of O-GlcNAcylation in Drosophila.", "journal": "Bioorganic & medicinal chemistry", "date": "2025-04-10", "authors": "Lei Cong, Chen Zihan, Hao Yi, Huang Wanping, Chu Tianyu, Xiao Kangming, Zhang Che, Zhou Wen, Li Chenjian, Chen Xing", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9VDD0", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VDD0" } ], "reference": [ { "type": "PubMed", "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499" } ] } ], "crossref": [ { "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9VDD0", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VDD0", "database": "O-GlcNAc Database", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PPETGSIMLIVRLMALYQQS", "down_seq": "KKEEFLEQLQSFQSLIVNRE", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr163", "evidence": [ { "id": "40245499", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40245499" }, { "id": "Q9VDD0", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VDD0" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "163", "end_pos": "163" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9VDP8-1.30.30", "start_pos": 30, "end_pos": 30, "uniprot_canonical_ac": "Q9VDP8-1", "length": 357, "uniprot_id": "Q9VDP8_DROME", "protein_name": "Midlife crisis", "refseq_ac": "NP_650865", "refseq_name": "midlife crisis", "gene_name": "mdlc", "gene_names_uniprotkb": "mdlc; CG4973; Dmel\\CG4973; Dmel_CG4973", "gene_names_refseq": "CG4973; Dmel\\CG4973; mdlc", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VDP8", "url": "https://www.uniprot.org/uniprotkb/Q9VDP8" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Quantitative and site-specific chemoproteomic profiling of O-GlcNAcylation in Drosophila.", "journal": "Bioorganic & medicinal chemistry", "date": "2025-04-10", "authors": "Lei Cong, Chen Zihan, Hao Yi, Huang Wanping, Chu Tianyu, Xiao Kangming, Zhang Che, Zhou Wen, Li Chenjian, Chen Xing", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9VDP8", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VDP8" } ], "reference": [ { "type": "PubMed", "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499" } ] } ], "crossref": [ { "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9VDP8", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VDP8", "database": "O-GlcNAc Database", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SFGFKKRNLKKGAGIRRKKE", "down_seq": "SSDESAKSSDEETKGKASAL", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr30", "evidence": [ { "id": "40245499", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40245499" }, { "id": "Q9VDP8", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VDP8" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "30", "end_pos": "30" }, { "start_pos": "31", "end_pos": "31" }, { "start_pos": "35", "end_pos": "35" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 1, "direction": "upstream", "id": "Q9VDP8-1.31.31", "categories": [ "glycosylation_flag" ] }, { "distance": 5, "direction": "upstream", "id": "Q9VDP8-1.35.35", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9VDP8-1.31.31", "start_pos": 31, "end_pos": 31, "uniprot_canonical_ac": "Q9VDP8-1", "length": 357, "uniprot_id": "Q9VDP8_DROME", "protein_name": "Midlife crisis", "refseq_ac": "NP_650865", "refseq_name": "midlife crisis", "gene_name": "mdlc", "gene_names_uniprotkb": "mdlc; CG4973; Dmel\\CG4973; Dmel_CG4973", "gene_names_refseq": "CG4973; Dmel\\CG4973; mdlc", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VDP8", "url": "https://www.uniprot.org/uniprotkb/Q9VDP8" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Quantitative and site-specific chemoproteomic profiling of O-GlcNAcylation in Drosophila.", "journal": "Bioorganic & medicinal chemistry", "date": "2025-04-10", "authors": "Lei Cong, Chen Zihan, Hao Yi, Huang Wanping, Chu Tianyu, Xiao Kangming, Zhang Che, Zhou Wen, Li Chenjian, Chen Xing", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9VDP8", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VDP8" } ], "reference": [ { "type": "PubMed", "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499" } ] } ], "crossref": [ { "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9VDP8", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VDP8", "database": "O-GlcNAc Database", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "FGFKKRNLKKGAGIRRKKET", "down_seq": "SDESAKSSDEETKGKASALV", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser31", "evidence": [ { "id": "40245499", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40245499" }, { "id": "Q9VDP8", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VDP8" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "30", "end_pos": "30" }, { "start_pos": "31", "end_pos": "31" }, { "start_pos": "35", "end_pos": "35" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 1, "direction": "downstream", "id": "Q9VDP8-1.30.30", "categories": [ "glycosylation_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q9VDP8-1.35.35", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9VDP8-1.35.35", "start_pos": 35, "end_pos": 35, "uniprot_canonical_ac": "Q9VDP8-1", "length": 357, "uniprot_id": "Q9VDP8_DROME", "protein_name": "Midlife crisis", "refseq_ac": "NP_650865", "refseq_name": "midlife crisis", "gene_name": "mdlc", "gene_names_uniprotkb": "mdlc; CG4973; Dmel\\CG4973; Dmel_CG4973", "gene_names_refseq": "CG4973; Dmel\\CG4973; mdlc", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VDP8", "url": "https://www.uniprot.org/uniprotkb/Q9VDP8" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Quantitative and site-specific chemoproteomic profiling of O-GlcNAcylation in Drosophila.", "journal": "Bioorganic & medicinal chemistry", "date": "2025-04-10", "authors": "Lei Cong, Chen Zihan, Hao Yi, Huang Wanping, Chu Tianyu, Xiao Kangming, Zhang Che, Zhou Wen, Li Chenjian, Chen Xing", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9VDP8", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VDP8" } ], "reference": [ { "type": "PubMed", "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499" } ] } ], "crossref": [ { "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9VDP8", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VDP8", "database": "O-GlcNAc Database", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "KRNLKKGAGIRRKKETSSDE", "down_seq": "AKSSDEETKGKASALVRAEN", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser35", "evidence": [ { "id": "40245499", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40245499" }, { "id": "Q9VDP8", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VDP8" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "30", "end_pos": "30" }, { "start_pos": "31", "end_pos": "31" }, { "start_pos": "35", "end_pos": "35" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 5, "direction": "downstream", "id": "Q9VDP8-1.30.30", "categories": [ "glycosylation_flag" ] }, { "distance": 4, "direction": "downstream", "id": "Q9VDP8-1.31.31", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9VDY3-1.102.102", "start_pos": 102, "end_pos": 102, "uniprot_canonical_ac": "Q9VDY3-1", "length": 555, "uniprot_id": "Q9VDY3_DROME", "protein_name": "CUB domain-containing protein", "refseq_ac": "NP_001287405", "refseq_name": "uncharacterized protein, isoform B", "gene_name": "Dmel\\CG14280", "gene_names_uniprotkb": "Dmel\\CG14280; CG14280; Dmel_CG14280", "gene_names_refseq": "CG14280; Dmel\\CG14280", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VDY3", "url": "https://www.uniprot.org/uniprotkb/Q9VDY3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DGGMGGMENPPETEAPMPMP", "down_seq": "PGTPPPEPAPTEPEEPEPTI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr102", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "102", "end_pos": "102" }, { "start_pos": "145", "end_pos": "145" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VDY3-1.145.145", "start_pos": 145, "end_pos": 145, "uniprot_canonical_ac": "Q9VDY3-1", "length": 555, "uniprot_id": "Q9VDY3_DROME", "protein_name": "CUB domain-containing protein", "refseq_ac": "NP_001287405", "refseq_name": "uncharacterized protein, isoform B", "gene_name": "Dmel\\CG14280", "gene_names_uniprotkb": "Dmel\\CG14280; CG14280; Dmel_CG14280", "gene_names_refseq": "CG14280; Dmel\\CG14280", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VDY3", "url": "https://www.uniprot.org/uniprotkb/Q9VDY3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RPTTIPVEEPSPQPPTMMVP", "down_seq": "PSASPGMQPSSKPRPTGKPS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr145", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "102", "end_pos": "102" }, { "start_pos": "145", "end_pos": "145" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VE73-1.90.90", "start_pos": 90, "end_pos": 90, "uniprot_canonical_ac": "Q9VE73-1", "length": 487, "uniprot_id": "Q9VE73_DROME", "protein_name": "WD repeat-containing protein 37", "refseq_ac": "NP_650723", "refseq_name": "WD repeat domain 37", "gene_name": "Wdr37", "gene_names_uniprotkb": "Wdr37; CG12333; Dmel\\CG12333; Dmel_CG12333; wdr37", "gene_names_refseq": "CG12333; Dmel\\CG12333; Wdr37; wdr37", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VE73", "url": "https://www.uniprot.org/uniprotkb/Q9VE73" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DARSAAGGSMSTQASSAALA", "down_seq": "PATQTDEVAGSFLAAASSTH", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr90", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "90", "end_pos": "90" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VEH6-1.98.98", "start_pos": 98, "end_pos": 98, "uniprot_canonical_ac": "Q9VEH6-1", "length": 210, "uniprot_id": "Q9VEH6_DROME", "protein_name": "Uncharacterized protein", "refseq_ac": "NP_732252", "refseq_name": "uncharacterized protein", "gene_name": "Dmel\\CG14323", "gene_names_uniprotkb": "Dmel\\CG14323; CG14323; Dmel_CG14323", "gene_names_refseq": "CG14323; Dmel\\CG14323", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VEH6", "url": "https://www.uniprot.org/uniprotkb/Q9VEH6" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "NCPVYGCSLAAIGPQPGYYA", "down_seq": "PAGFYTMPLNQQQAQGNSNV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr98", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "98", "end_pos": "98" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VES0-1.105.105", "start_pos": 105, "end_pos": 105, "uniprot_canonical_ac": "Q9VES0-1", "length": 543, "uniprot_id": "Q9VES0_DROME", "protein_name": "Spp2/MOS2 G-patch domain-containing protein", "refseq_ac": "NP_650571", "refseq_name": "uncharacterized protein", "gene_name": "Gpkow", "gene_names_uniprotkb": "Gpkow; CG10324; Dmel\\CG10324; Dmel_CG10324", "gene_names_refseq": "CG10324; Dmel\\CG10324", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VES0", "url": "https://www.uniprot.org/uniprotkb/Q9VES0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DPEEVTPVAQSIAEVTAGGP", "down_seq": "ESLEQRAARELISAIQNNGA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr105", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "105", "end_pos": "105" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VES7-1.458.458", "start_pos": 458, "end_pos": 458, "uniprot_canonical_ac": "Q9VES7-1", "length": 499, "uniprot_id": "Q9VES7_DROME", "protein_name": "Fatty acyl-CoA reductase", "refseq_ac": "NP_650566", "refseq_name": "uncharacterized protein", "gene_name": "Dmel\\CG17562", "gene_names_uniprotkb": "Dmel\\CG17562; CG17562; Dmel_CG17562", "gene_names_refseq": "CG17562; Dmel\\CG17562", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VES7", "url": "https://www.uniprot.org/uniprotkb/Q9VES7" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "KEYFVQALRGMRQFLGNEAP", "down_seq": "PESIAQGKKLIKRLKLLHHI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr458", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "458", "end_pos": "458" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VF24-1.1322.1322", "start_pos": 1322, "end_pos": 1322, "uniprot_canonical_ac": "Q9VF24-1", "length": 1470, "uniprot_id": "Q9VF24_DROME", "protein_name": "Crossveinless d", "refseq_ac": "NP_732076", "refseq_name": "crossveinless d", "gene_name": "cv-d", "gene_names_uniprotkb": "cv-d; CG31150; CG9622; CG9625; CG9627; Cv-D; Cv-d; Dmel\\CG31150; Dmel_CG31150", "gene_names_refseq": "CG31150; CG9622; CG9625; CG9627; Cv-D; Cv-d; Dmel\\CG31150; cv-d", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VF24", "url": "https://www.uniprot.org/uniprotkb/Q9VF24" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DCLTLLVADCSPLPQIAVFV", "down_seq": "PSPVQGLSTNYGLRVHIGQN", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1322", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1322", "end_pos": "1322" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VF39-1.69.69", "start_pos": 69, "end_pos": 69, "uniprot_canonical_ac": "Q9VF39-1", "length": 460, "uniprot_id": "Q9VF39_DROME", "protein_name": "Protein FAM114A2", "refseq_ac": "NP_650488", "refseq_name": "uncharacterized protein", "gene_name": "Fam114A", "gene_names_uniprotkb": "Fam114A; CG9590; Dmel\\CG9590; Dmel_CG9590", "gene_names_refseq": "CG9590; Dmel\\CG9590", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VF39", "url": "https://www.uniprot.org/uniprotkb/Q9VF39" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Quantitative and site-specific chemoproteomic profiling of O-GlcNAcylation in Drosophila.", "journal": "Bioorganic & medicinal chemistry", "date": "2025-04-10", "authors": "Lei Cong, Chen Zihan, Hao Yi, Huang Wanping, Chu Tianyu, Xiao Kangming, Zhang Che, Zhou Wen, Li Chenjian, Chen Xing", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9VF39", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VF39" } ], "reference": [ { "type": "PubMed", "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499" } ] } ], "crossref": [ { "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9VF39", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VF39", "database": "O-GlcNAc Database", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "SRNDAKGTAENQEKLETPRI", "down_seq": "APATASATSSSWGLWGGKLS", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser69", "evidence": [ { "id": "40245499", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40245499" }, { "id": "Q9VF39", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VF39" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "69", "end_pos": "69" }, { "start_pos": "77", "end_pos": "77" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 8, "direction": "upstream", "id": "Q9VF39-1.77.77", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9VF39-1.77.77", "start_pos": 77, "end_pos": 77, "uniprot_canonical_ac": "Q9VF39-1", "length": 460, "uniprot_id": "Q9VF39_DROME", "protein_name": "Protein FAM114A2", "refseq_ac": "NP_650488", "refseq_name": "uncharacterized protein", "gene_name": "Fam114A", "gene_names_uniprotkb": "Fam114A; CG9590; Dmel\\CG9590; Dmel_CG9590", "gene_names_refseq": "CG9590; Dmel\\CG9590", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VF39", "url": "https://www.uniprot.org/uniprotkb/Q9VF39" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Quantitative and site-specific chemoproteomic profiling of O-GlcNAcylation in Drosophila.", "journal": "Bioorganic & medicinal chemistry", "date": "2025-04-10", "authors": "Lei Cong, Chen Zihan, Hao Yi, Huang Wanping, Chu Tianyu, Xiao Kangming, Zhang Che, Zhou Wen, Li Chenjian, Chen Xing", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9VF39", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VF39" } ], "reference": [ { "type": "PubMed", "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499" } ] } ], "crossref": [ { "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9VF39", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VF39", "database": "O-GlcNAc Database", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AENQEKLETPRISAPATASA", "down_seq": "SSSWGLWGGKLSSVLTTATE", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr77", "evidence": [ { "id": "40245499", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40245499" }, { "id": "Q9VF39", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VF39" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "69", "end_pos": "69" }, { "start_pos": "77", "end_pos": "77" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 8, "direction": "downstream", "id": "Q9VF39-1.69.69", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9VF93-1.162.162", "start_pos": 162, "end_pos": 162, "uniprot_canonical_ac": "Q9VF93-1", "length": 470, "uniprot_id": "Q9VF93_DROME", "protein_name": "Uncharacterized protein", "refseq_ac": "NP_650445", "refseq_name": "uncharacterized protein", "gene_name": "Dmel\\CG6276", "gene_names_uniprotkb": "Dmel\\CG6276; CG6276; Dmel_CG6276", "gene_names_refseq": "CG6276; Dmel\\CG6276", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VF93", "url": "https://www.uniprot.org/uniprotkb/Q9VF93" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RMQRERSVTIPGSSSIGGQP", "down_seq": "PSAHQSPPAQQLDNYLDYFD", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr162", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "162", "end_pos": "162" }, { "start_pos": "358", "end_pos": "358" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VF93-1.358.358", "start_pos": 358, "end_pos": 358, "uniprot_canonical_ac": "Q9VF93-1", "length": 470, "uniprot_id": "Q9VF93_DROME", "protein_name": "Uncharacterized protein", "refseq_ac": "NP_650445", "refseq_name": "uncharacterized protein", "gene_name": "Dmel\\CG6276", "gene_names_uniprotkb": "Dmel\\CG6276; CG6276; Dmel_CG6276", "gene_names_refseq": "CG6276; Dmel\\CG6276", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VF93", "url": "https://www.uniprot.org/uniprotkb/Q9VF93" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GGGGGGGVPGTAGLSEAELP", "down_seq": "PSTAAVATPMAPSSSVSASS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr358", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "162", "end_pos": "162" }, { "start_pos": "358", "end_pos": "358" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VFF3-1.296.296", "start_pos": 296, "end_pos": 296, "uniprot_canonical_ac": "Q9VFF3-1", "length": 900, "uniprot_id": "EXOSX_DROME", "protein_name": "Exosome complex component 10 homolog", "refseq_ac": "NP_001097795", "refseq_name": "Rrp6, isoform B", "gene_name": "Rrp6", "gene_names_uniprotkb": "Rrp6; CG7292", "gene_names_refseq": "CG7292; DmRrp6; Dmel\\CG7292; RRP6; Rrp6; dRrp6; rrp6", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VFF3", "url": "https://www.uniprot.org/uniprotkb/Q9VFF3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "An Interaction between RRP6 and SU(VAR)3-9 Targets RRP6 to Heterochromatin and Contributes to Heterochromatin Maintenance in Drosophila melanogaster.", "journal": "PLoS genetics", "date": "2015-09", "authors": "Eberle Andrea B, Jord\u00e1n-Pla Antonio, Ga\u00f1ez-Zapater Antoni, Hessle Viktoria, Silberberg Gilad, von Euler Anne, Silverstein Rebecca A, Visa Neus", "evidence": [ { "database": "UniProtKB", "id": "Q9VFF3", "url": "https://www.uniprot.org/uniprotkb/Q9VFF3" } ], "reference": [ { "type": "PubMed", "id": "26389589", "url": "https://glygen.org/publication/PubMed/26389589" } ] } ], "crossref": [ { "id": "Q9VFF3", "url": "https://www.uniprot.org/uniprotkb/Q9VFF3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "26389589", "url": "https://glygen.org/publication/PubMed/26389589", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "TVEKLKQALEELRQAPQIAI", "down_seq": "VEHHSYRTFMGITCLVQMST", "mutagenesis": [ { "sequence_org": "D", "sequence_mut": "A", "comment": "Causes accumulation of transcripts derived from retrotransposon and repeat sequences.", "evidence": [ { "database": "UniProtKB", "id": "Q9VFF3", "url": "https://www.uniprot.org/uniprotkb/Q9VFF3" }, { "database": "PubMed", "id": "26389589", "url": "https://glygen.org/publication/PubMed/26389589" } ] } ], "all_sites": [ { "type": "mutagenesis", "site_list": [ { "start_pos": "296", "end_pos": "296" }, { "start_pos": "419", "end_pos": "419" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9VFF3-1.419.419", "start_pos": 419, "end_pos": 419, "uniprot_canonical_ac": "Q9VFF3-1", "length": 900, "uniprot_id": "EXOSX_DROME", "protein_name": "Exosome complex component 10 homolog", "refseq_ac": "NP_001097795", "refseq_name": "Rrp6, isoform B", "gene_name": "Rrp6", "gene_names_uniprotkb": "Rrp6; CG7292", "gene_names_refseq": "CG7292; DmRrp6; Dmel\\CG7292; RRP6; Rrp6; dRrp6; rrp6", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VFF3", "url": "https://www.uniprot.org/uniprotkb/Q9VFF3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "RRP6/EXOSC10 is required for the repair of DNA double-strand breaks by homologous recombination.", "journal": "Journal of cell science", "date": "2015-03-15", "authors": "Marin-Vicente Consuelo, Domingo-Prim Judit, Eberle Andrea B, Visa Neus", "evidence": [ { "database": "UniProtKB", "id": "Q9VFF3", "url": "https://www.uniprot.org/uniprotkb/Q9VFF3" } ], "reference": [ { "type": "PubMed", "id": "25632158", "url": "https://glygen.org/publication/PubMed/25632158" } ] }, { "title": "An Interaction between RRP6 and SU(VAR)3-9 Targets RRP6 to Heterochromatin and Contributes to Heterochromatin Maintenance in Drosophila melanogaster.", "journal": "PLoS genetics", "date": "2015-09", "authors": "Eberle Andrea B, Jord\u00e1n-Pla Antonio, Ga\u00f1ez-Zapater Antoni, Hessle Viktoria, Silberberg Gilad, von Euler Anne, Silverstein Rebecca A, Visa Neus", "evidence": [ { "database": "UniProtKB", "id": "Q9VFF3", "url": "https://www.uniprot.org/uniprotkb/Q9VFF3" } ], "reference": [ { "type": "PubMed", "id": "26389589", "url": "https://glygen.org/publication/PubMed/26389589" } ] } ], "crossref": [ { "id": "Q9VFF3", "url": "https://www.uniprot.org/uniprotkb/Q9VFF3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "25632158", "url": "https://glygen.org/publication/PubMed/25632158", "database": "PubMed", "categories": [ "Other" ] }, { "id": "26389589", "url": "https://glygen.org/publication/PubMed/26389589", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "Y", "start_aa": "Y", "up_seq": "DKSLQLADWRMRPLPQQLVD", "down_seq": "ARQDTHFLIYVYGRMTNDLL", "mutagenesis": [ { "sequence_org": "Y", "sequence_mut": "A", "comment": "Results in reduced growth rate of the cells after irradiation. Reduces Rrp6-mediated recruitment of spn-A to DNA double-strand breaks and efficiency of DNA repair. Does not affect the abundance of spn-A. Does not inhibit interaction with spn-A. Causes accumulation of transcripts derived from retrotransposon and repeat sequences.", "evidence": [ { "database": "UniProtKB", "id": "Q9VFF3", "url": "https://www.uniprot.org/uniprotkb/Q9VFF3" }, { "database": "PubMed", "id": "25632158", "url": "https://glygen.org/publication/PubMed/25632158" }, { "database": "PubMed", "id": "26389589", "url": "https://glygen.org/publication/PubMed/26389589" } ] } ], "all_sites": [ { "type": "mutagenesis", "site_list": [ { "start_pos": "296", "end_pos": "296" }, { "start_pos": "419", "end_pos": "419" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9VFK4-1.191.191", "start_pos": 191, "end_pos": 191, "uniprot_canonical_ac": "Q9VFK4-1", "length": 721, "uniprot_id": "Q9VFK4_DROME", "protein_name": "NK7.1, isoform A; NK7.1, isoform B; NK7.1, isoform C; NK7.1, isoform D", "refseq_ac": "NP_001247103", "refseq_name": "NK7.1, isoform C", "gene_name": "NK7.1", "gene_names_uniprotkb": "NK7.1; CG8524; Dmel\\CG8524; Dmel_CG8524; NK-7.1; NK7", "gene_names_refseq": "CG8524; Dmel\\CG8524; NK-7.1; NK7.1; NK7", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VFK4", "url": "https://www.uniprot.org/uniprotkb/Q9VFK4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TPGPPTNWHAHVYDRLPPHP", "down_seq": "PHSIADILGMSFVKKERPEV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr191", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "191", "end_pos": "191" }, { "start_pos": "495", "end_pos": "495" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VFK4-1.495.495", "start_pos": 495, "end_pos": 495, "uniprot_canonical_ac": "Q9VFK4-1", "length": 721, "uniprot_id": "Q9VFK4_DROME", "protein_name": "NK7.1, isoform A; NK7.1, isoform B; NK7.1, isoform C; NK7.1, isoform D", "refseq_ac": "NP_001247103", "refseq_name": "NK7.1, isoform C", "gene_name": "NK7.1", "gene_names_uniprotkb": "NK7.1; CG8524; Dmel\\CG8524; Dmel_CG8524; NK-7.1; NK7", "gene_names_refseq": "CG8524; Dmel\\CG8524; NK-7.1; NK7.1; NK7", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VFK4", "url": "https://www.uniprot.org/uniprotkb/Q9VFK4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ATTTPSGEPTDKRSSNATSP", "down_seq": "VGNAATIAEIKKSPKSPNRG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr495", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "191", "end_pos": "191" }, { "start_pos": "495", "end_pos": "495" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VFM4-1.20.20", "start_pos": 20, "end_pos": 20, "uniprot_canonical_ac": "Q9VFM4-1", "length": 76, "uniprot_id": "Q9VFM4_DROME", "protein_name": "Uncharacterized protein", "refseq_ac": "NP_001262562", "refseq_name": "uncharacterized protein, isoform B", "gene_name": "Dmel\\CG42500", "gene_names_uniprotkb": "Dmel\\CG42500; CG14359; CG42500; Dmel_CG42500", "gene_names_refseq": "CG14359; CG42500; Dmel\\CG42500", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VFM4", "url": "https://www.uniprot.org/uniprotkb/Q9VFM4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "", "down_seq": "PGDLRHVPVGHGGHPVNAGH", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr20", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "20", "end_pos": "20" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VFX0-1.100.100", "start_pos": 100, "end_pos": 100, "uniprot_canonical_ac": "Q9VFX0-1", "length": 994, "uniprot_id": "Q9VFX0_DROME", "protein_name": "Aminopeptidase", "refseq_ac": "NP_650273", "refseq_name": "uncharacterized protein", "gene_name": "Dmel\\CG8773", "gene_names_uniprotkb": "Dmel\\CG8773; CG8773; Dmel_CG8773", "gene_names_refseq": "CG8773; Dmel\\CG8773", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VFX0", "url": "https://www.uniprot.org/uniprotkb/Q9VFX0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TAEPGSTAEPGSTASPGSTV", "down_seq": "PGSTASTSEPGTTASPEKID", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr100", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "100", "end_pos": "100" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VFX5-1.39.39", "start_pos": 39, "end_pos": 39, "uniprot_canonical_ac": "Q9VFX5-1", "length": 408, "uniprot_id": "Q9VFX5_DROME", "protein_name": "Fatty acid desaturase domain-containing protein", "refseq_ac": "NP_731781", "refseq_name": "uncharacterized protein", "gene_name": "Dmel\\CG8630", "gene_names_uniprotkb": "Dmel\\CG8630; CG8630; Dmel SAMN; Dmel_CG8630", "gene_names_refseq": "CG8630; Dmel SAMN; Dmel\\CG8630", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VFX5", "url": "https://www.uniprot.org/uniprotkb/Q9VFX5" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DGNNNKMAATPAASAAPSAA", "down_seq": "PSQKVAKKAEAKTPENKPYE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr39", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "39", "end_pos": "39" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VG26-1.62.62", "start_pos": 62, "end_pos": 62, "uniprot_canonical_ac": "Q9VG26-1", "length": 213, "uniprot_id": "Q9VG26_DROME", "protein_name": "EF-hand domain-containing protein", "refseq_ac": "NP_731744", "refseq_name": "uncharacterized protein", "gene_name": "CG10135", "gene_names_uniprotkb": "CG10135; CBP9; CG14388; CG31345; Dmel\\CG31345; Dmel_CG31345", "gene_names_refseq": "CBP9; CG10135; CG14388; CG31345; Dmel\\CG31345", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VG26", "url": "https://www.uniprot.org/uniprotkb/Q9VG26" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Quantitative and site-specific chemoproteomic profiling of O-GlcNAcylation in Drosophila.", "journal": "Bioorganic & medicinal chemistry", "date": "2025-04-10", "authors": "Lei Cong, Chen Zihan, Hao Yi, Huang Wanping, Chu Tianyu, Xiao Kangming, Zhang Che, Zhou Wen, Li Chenjian, Chen Xing", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9VG26", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VG26" } ], "reference": [ { "type": "PubMed", "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499" } ] } ], "crossref": [ { "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9VG26", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VG26", "database": "O-GlcNAc Database", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "ATGILGLSRSFRVMDDDGSK", "down_seq": "LSPEEFKKGVTDIGLDLTDS", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser62", "evidence": [ { "id": "40245499", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40245499" }, { "id": "Q9VG26", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VG26" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "62", "end_pos": "62" }, { "start_pos": "64", "end_pos": "64" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "upstream", "id": "Q9VG26-1.64.64", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9VG26-1.64.64", "start_pos": 64, "end_pos": 64, "uniprot_canonical_ac": "Q9VG26-1", "length": 213, "uniprot_id": "Q9VG26_DROME", "protein_name": "EF-hand domain-containing protein", "refseq_ac": "NP_731744", "refseq_name": "uncharacterized protein", "gene_name": "CG10135", "gene_names_uniprotkb": "CG10135; CBP9; CG14388; CG31345; Dmel\\CG31345; Dmel_CG31345", "gene_names_refseq": "CBP9; CG10135; CG14388; CG31345; Dmel\\CG31345", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VG26", "url": "https://www.uniprot.org/uniprotkb/Q9VG26" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Quantitative and site-specific chemoproteomic profiling of O-GlcNAcylation in Drosophila.", "journal": "Bioorganic & medicinal chemistry", "date": "2025-04-10", "authors": "Lei Cong, Chen Zihan, Hao Yi, Huang Wanping, Chu Tianyu, Xiao Kangming, Zhang Che, Zhou Wen, Li Chenjian, Chen Xing", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9VG26", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VG26" } ], "reference": [ { "type": "PubMed", "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499" } ] } ], "crossref": [ { "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9VG26", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VG26", "database": "O-GlcNAc Database", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "GILGLSRSFRVMDDDGSKSL", "down_seq": "PEEFKKGVTDIGLDLTDSEI", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser64", "evidence": [ { "id": "40245499", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40245499" }, { "id": "Q9VG26", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VG26" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "62", "end_pos": "62" }, { "start_pos": "64", "end_pos": "64" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "downstream", "id": "Q9VG26-1.62.62", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9VGJ0-1.516.516", "start_pos": 516, "end_pos": 516, "uniprot_canonical_ac": "Q9VGJ0-1", "length": 686, "uniprot_id": "Q9VGJ0_DROME", "protein_name": "Thrombospondin-like N-terminal domain-containing protein", "refseq_ac": "NP_001262482", "refseq_name": "uncharacterized protein, isoform B", "gene_name": "Dmel\\CG12594", "gene_names_uniprotkb": "Dmel\\CG12594; CG12594; Dmel_CG12594", "gene_names_refseq": "CG12594; Dmel\\CG12594", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VGJ0", "url": "https://www.uniprot.org/uniprotkb/Q9VGJ0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DAYSNLDLTTAGLMGTAFSP", "down_seq": "PSTPYNMGYIRSWRNLLNFT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr516", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "516", "end_pos": "516" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VGU4-1.466.466", "start_pos": 466, "end_pos": 466, "uniprot_canonical_ac": "Q9VGU4-1", "length": 520, "uniprot_id": "Q9VGU4_DROME", "protein_name": "Leash", "refseq_ac": "NP_650037", "refseq_name": "leash", "gene_name": "Leash", "gene_names_uniprotkb": "Leash; CG32471; CG4674; Dmel\\CG4674; Dmel_CG4674; leash", "gene_names_refseq": "CG32471; CG4674; Dmel\\CG4674; Leash; leash", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VGU4", "url": "https://www.uniprot.org/uniprotkb/Q9VGU4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PQYSLLALTPPPAGVVAAPP", "down_seq": "GGAAAGGAPAYSQLPSTSAS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr466", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "466", "end_pos": "466" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VH09-1.961.961", "start_pos": 961, "end_pos": 961, "uniprot_canonical_ac": "Q9VH09-1", "length": 985, "uniprot_id": "Q9VH09_DROME", "protein_name": "Glycine cleavage system P protein", "refseq_ac": "NP_001262456", "refseq_name": "uncharacterized protein, isoform B", "gene_name": "Gldc", "gene_names_uniprotkb": "Gldc; CG3999; Dmel\\CG3999; Dmel_CG3999", "gene_names_refseq": "CG3999; Dmel\\CG3999", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VH09", "url": "https://www.uniprot.org/uniprotkb/Q9VH09" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TREQAAFPAIFVKPDAKIWP", "down_seq": "VGRIDDAYGDKHLVCTCPPI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr961", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "961", "end_pos": "961" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VHH8-1.51.51", "start_pos": 51, "end_pos": 51, "uniprot_canonical_ac": "Q9VHH8-1", "length": 557, "uniprot_id": "Q9VHH8_DROME", "protein_name": "Beag", "refseq_ac": "NP_649865", "refseq_name": "beag", "gene_name": "beag", "gene_names_uniprotkb": "beag; CG18005; Dmel\\CG18005; Dmel_CG18005", "gene_names_refseq": "CG18005; Dmel\\CG18005; beag", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VHH8", "url": "https://www.uniprot.org/uniprotkb/Q9VHH8" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PGSGTSSTSAGGSLATATFA", "down_seq": "PSTAPGTTGLSGEKKKGQSS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr51", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "51", "end_pos": "51" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VIC7-1.1257.1257", "start_pos": 1257, "end_pos": 1257, "uniprot_canonical_ac": "Q9VIC7-1", "length": 1354, "uniprot_id": "Q9VIC7_DROME", "protein_name": "Neuroligin 1, isoform D; Neuroligin 1, isoform E", "refseq_ac": "NP_001246966", "refseq_name": "neuroligin 1, isoform E", "gene_name": "Nlg1", "gene_names_uniprotkb": "Nlg1; CG12148; CG14596; CG31146; DNlg1; Dmel\\CG31146; Dmel_CG31146; Nlg-1; anon-WO0118547.256; dnlg1; neuroligin; nlg1", "gene_names_refseq": "CG12148; CG14596; CG31146; DNlg1; Dmel\\CG31146; Nlg-1; Nlg1; anon-WO0118547.256; dnlg1; neuroligin; nlg1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VIC7", "url": "https://www.uniprot.org/uniprotkb/Q9VIC7" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SSRNSLIPRPTKPAESQSQA", "down_seq": "PAGPAGESLGSTGMATASRI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1257", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1257", "end_pos": "1257" }, { "start_pos": "697", "end_pos": "697" }, { "start_pos": "770", "end_pos": "770" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VIC7-1.697.697", "start_pos": 697, "end_pos": 697, "uniprot_canonical_ac": "Q9VIC7-1", "length": 1354, "uniprot_id": "Q9VIC7_DROME", "protein_name": "Neuroligin 1, isoform D; Neuroligin 1, isoform E", "refseq_ac": "NP_001246966", "refseq_name": "neuroligin 1, isoform E", "gene_name": "Nlg1", "gene_names_uniprotkb": "Nlg1; CG12148; CG14596; CG31146; DNlg1; Dmel\\CG31146; Dmel_CG31146; Nlg-1; anon-WO0118547.256; dnlg1; neuroligin; nlg1", "gene_names_refseq": "CG12148; CG14596; CG31146; DNlg1; Dmel\\CG31146; Nlg-1; Nlg1; anon-WO0118547.256; dnlg1; neuroligin; nlg1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VIC7", "url": "https://www.uniprot.org/uniprotkb/Q9VIC7" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LDWPEFNRRAQAYLNIGIPP", "down_seq": "VGYKYRQIYMNFWNKELPDE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr697", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1257", "end_pos": "1257" }, { "start_pos": "697", "end_pos": "697" }, { "start_pos": "770", "end_pos": "770" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VIC7-1.770.770", "start_pos": 770, "end_pos": 770, "uniprot_canonical_ac": "Q9VIC7-1", "length": 1354, "uniprot_id": "Q9VIC7_DROME", "protein_name": "Neuroligin 1, isoform D; Neuroligin 1, isoform E", "refseq_ac": "NP_001246966", "refseq_name": "neuroligin 1, isoform E", "gene_name": "Nlg1", "gene_names_uniprotkb": "Nlg1; CG12148; CG14596; CG31146; DNlg1; Dmel\\CG31146; Dmel_CG31146; Nlg-1; anon-WO0118547.256; dnlg1; neuroligin; nlg1", "gene_names_refseq": "CG12148; CG14596; CG31146; DNlg1; Dmel\\CG31146; Nlg-1; Nlg1; anon-WO0118547.256; dnlg1; neuroligin; nlg1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VIC7", "url": "https://www.uniprot.org/uniprotkb/Q9VIC7" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AEDPVRTLKLLLQEPSLAGP", "down_seq": "QSGESTETAAENMYNAPPTF", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr770", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1257", "end_pos": "1257" }, { "start_pos": "697", "end_pos": "697" }, { "start_pos": "770", "end_pos": "770" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VIE0-1.387.387", "start_pos": 387, "end_pos": 387, "uniprot_canonical_ac": "Q9VIE0-1", "length": 704, "uniprot_id": "Q9VIE0_DROME", "protein_name": "LEM domain-containing protein", "refseq_ac": "NP_610099", "refseq_name": "uncharacterized protein", "gene_name": "dLEM3", "gene_names_uniprotkb": "dLEM3; CG8679; Dmel\\CG8679; Dmel_CG8679", "gene_names_refseq": "CG8679; Dmel\\CG8679; dLEM3", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VIE0", "url": "https://www.uniprot.org/uniprotkb/Q9VIE0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Quantitative and site-specific chemoproteomic profiling of O-GlcNAcylation in Drosophila.", "journal": "Bioorganic & medicinal chemistry", "date": "2025-04-10", "authors": "Lei Cong, Chen Zihan, Hao Yi, Huang Wanping, Chu Tianyu, Xiao Kangming, Zhang Che, Zhou Wen, Li Chenjian, Chen Xing", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9VIE0", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VIE0" } ], "reference": [ { "type": "PubMed", "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499" } ] } ], "crossref": [ { "id": "40245499", "url": "https://glygen.org/publication/PubMed/40245499", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9VIE0", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VIE0", "database": "O-GlcNAc Database", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LVFYEARYLQNRDRREPVEQ", "down_seq": "PKERKHDLESSVSTNYTLPL", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr387", "evidence": [ { "id": "40245499", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40245499" }, { "id": "Q9VIE0", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VIE0" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "387", "end_pos": "387" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9VIP3-1.199.199", "start_pos": 199, "end_pos": 199, "uniprot_canonical_ac": "Q9VIP3-1", "length": 328, "uniprot_id": "Q9VIP3_DROME", "protein_name": "Phosphatidylinositol-specific phospholipase C X domain-containing protein", "refseq_ac": "NP_001260618", "refseq_name": "uncharacterized protein, isoform B", "gene_name": "38B.13", "gene_names_uniprotkb": "38B.13; CG10747; Dmel\\CG10747; Dmel_CG10747", "gene_names_refseq": "38B.13; CG10747; Dmel\\CG10747", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VIP3", "url": "https://www.uniprot.org/uniprotkb/Q9VIP3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "IYRRCPIPLPLRFWPSYAWP", "down_seq": "PWPNKASVKKLQSFLEDSLL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr199", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "199", "end_pos": "199" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VJ63-1.20.20", "start_pos": 20, "end_pos": 20, "uniprot_canonical_ac": "Q9VJ63-1", "length": 417, "uniprot_id": "Q9VJ63_DROME", "protein_name": "RUS family member 1", "refseq_ac": "NP_001286056", "refseq_name": "uncharacterized protein, isoform B", "gene_name": "Dmel\\CG10338", "gene_names_uniprotkb": "Dmel\\CG10338; CG10338; Dmel_CG10338", "gene_names_refseq": "CG10338; Dmel\\CG10338", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VJ63", "url": "https://www.uniprot.org/uniprotkb/Q9VJ63" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "", "down_seq": "PADQSNIVRVPLRGDKLVIQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr20", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "20", "end_pos": "20" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VJ80-1.1196.1196", "start_pos": 1196, "end_pos": 1196, "uniprot_canonical_ac": "Q9VJ80-1", "length": 1394, "uniprot_id": "Q9VJ80_DROME", "protein_name": "Uncharacterized protein", "refseq_ac": "NP_001286043", "refseq_name": "uncharacterized protein, isoform B", "gene_name": "Dmel\\CG10211", "gene_names_uniprotkb": "Dmel\\CG10211; CG10211; DBLOX; Dmel_CG10211", "gene_names_refseq": "CG10211; DBLOX; Dmel\\CG10211", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VJ80", "url": "https://www.uniprot.org/uniprotkb/Q9VJ80" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "IDLFPGAMTERPLQGGLVGP", "down_seq": "LACIIGIQFRQLRKCDRFWY", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1196", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1196", "end_pos": "1196" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VJF5-1.35.35", "start_pos": 35, "end_pos": 35, "uniprot_canonical_ac": "Q9VJF5-1", "length": 190, "uniprot_id": "Q9VJF5_DROME", "protein_name": "Uncharacterized protein", "refseq_ac": "NP_001260524", "refseq_name": "uncharacterized protein, isoform B", "gene_name": "Dmel\\CG15136", "gene_names_uniprotkb": "Dmel\\CG15136; CG15136; Dmel_CG15136", "gene_names_refseq": "CG15136; Dmel\\CG15136", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VJF5", "url": "https://www.uniprot.org/uniprotkb/Q9VJF5" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GEVGDAHSTPGSCPPPAAGD", "down_seq": "PPVVSRPLDRRLNPNAPVFV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr35", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "35", "end_pos": "35" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VJQ3-1.0.0", "start_pos": 0, "end_pos": 0, "uniprot_canonical_ac": "Q9VJQ3-1", "length": 438, "uniprot_id": "Q9VJQ3_DROME", "protein_name": "Protein yellow", "refseq_ac": "NP_001285947", "refseq_name": "yellow-c, isoform B", "gene_name": "yellow-c", "gene_names_uniprotkb": "yellow-c; BG:DS00929.8; CG4182; Dmel\\CG4182; Dmel_CG4182; Yellow C; anon-EST:ParkEST125; yell-c", "gene_names_refseq": "BG:DS00929.8; CG4182; Dmel\\CG4182; Yellow C; anon-EST:ParkEST125; yell-c; yellow-c", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VJQ3", "url": "https://www.uniprot.org/uniprotkb/Q9VJQ3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Drosophila O-GlcNAcase Mutants Reveal an Expanded Glycoproteome and Novel Growth and Longevity Phenotypes.", "journal": "Cells", "date": "2021", "authors": "Akan I, Halim A, Vakhrushev SY, Clausen H, Hanover JA", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9VJQ3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VJQ3" } ], "reference": [ { "type": "PubMed", "id": "33925313", "url": "https://glygen.org/publication/PubMed/33925313" } ] } ], "crossref": [ { "id": "33925313", "url": "https://glygen.org/publication/PubMed/33925313", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9VJQ3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VJQ3", "database": "O-GlcNAc Database", "categories": [ "Other" ] } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "evidence": [ { "id": "33925313", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33925313" }, { "id": "Q9VJQ3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VJQ3" } ] } ], "all_sites": [], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9VJZ3-1.117.117", "start_pos": 117, "end_pos": 117, "uniprot_canonical_ac": "Q9VJZ3-1", "length": 695, "uniprot_id": "Q9VJZ3_DROME", "protein_name": "B double prime 1, isoform A", "refseq_ac": "NP_609643", "refseq_name": "B double prime 1, isoform A", "gene_name": "Bdp1", "gene_names_uniprotkb": "Bdp1; CG9305; Dmel\\CG9305; Dmel_CG9305", "gene_names_refseq": "Bdp1; CG9305; Dmel\\CG9305", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VJZ3", "url": "https://www.uniprot.org/uniprotkb/Q9VJZ3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TTNGFPMSPSKAQARQRVRP", "down_seq": "PVFGQRRNSFVGSPMASDYE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr117", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "117", "end_pos": "117" }, { "start_pos": "53", "end_pos": "53" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VJZ3-1.53.53", "start_pos": 53, "end_pos": 53, "uniprot_canonical_ac": "Q9VJZ3-1", "length": 695, "uniprot_id": "Q9VJZ3_DROME", "protein_name": "B double prime 1, isoform A", "refseq_ac": "NP_609643", "refseq_name": "B double prime 1, isoform A", "gene_name": "Bdp1", "gene_names_uniprotkb": "Bdp1; CG9305; Dmel\\CG9305; Dmel_CG9305", "gene_names_refseq": "Bdp1; CG9305; Dmel\\CG9305", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VJZ3", "url": "https://www.uniprot.org/uniprotkb/Q9VJZ3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DEEEEAVVVEAEAESPPVAS", "down_seq": "PAAELELEADAIAFKMPASS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr53", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "117", "end_pos": "117" }, { "start_pos": "53", "end_pos": "53" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VK95-1.40.40", "start_pos": 40, "end_pos": 40, "uniprot_canonical_ac": "Q9VK95-1", "length": 924, "uniprot_id": "Q9VK95_DROME", "protein_name": "Polycystic kidney disease 2", "refseq_ac": "NP_609561", "refseq_name": "polycystic kidney disease 2", "gene_name": "Pkd2", "gene_names_uniprotkb": "Pkd2; AMO; Amo; CG6504; Dmel\\CG6504; Dmel_CG6504; Dmpkd2; PKD2; TRPP2; TRPP; amo; pkd2", "gene_names_refseq": "AMO; Amo; CG6504; Dmel\\CG6504; Dmpkd2; PKD2; Pkd2; TRPP2; TRPP; amo; pkd2", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VK95", "url": "https://www.uniprot.org/uniprotkb/Q9VK95" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PRPPKTPPGASPRGTPTADS", "down_seq": "PGDVTPARGPPPPPATKRVS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr40", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "40", "end_pos": "40" }, { "start_pos": "45", "end_pos": "45" }, { "start_pos": "82", "end_pos": "82" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 5, "direction": "upstream", "id": "Q9VK95-1.45.45", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VK95-1.45.45", "start_pos": 45, "end_pos": 45, "uniprot_canonical_ac": "Q9VK95-1", "length": 924, "uniprot_id": "Q9VK95_DROME", "protein_name": "Polycystic kidney disease 2", "refseq_ac": "NP_609561", "refseq_name": "polycystic kidney disease 2", "gene_name": "Pkd2", "gene_names_uniprotkb": "Pkd2; AMO; Amo; CG6504; Dmel\\CG6504; Dmel_CG6504; Dmpkd2; PKD2; TRPP2; TRPP; amo; pkd2", "gene_names_refseq": "AMO; Amo; CG6504; Dmel\\CG6504; Dmpkd2; PKD2; Pkd2; TRPP2; TRPP; amo; pkd2", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VK95", "url": "https://www.uniprot.org/uniprotkb/Q9VK95" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TPPGASPRGTPTADSTPGDV", "down_seq": "PARGPPPPPATKRVSIGVGS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr45", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "40", "end_pos": "40" }, { "start_pos": "45", "end_pos": "45" }, { "start_pos": "82", "end_pos": "82" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 5, "direction": "downstream", "id": "Q9VK95-1.40.40", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VK95-1.82.82", "start_pos": 82, "end_pos": 82, "uniprot_canonical_ac": "Q9VK95-1", "length": 924, "uniprot_id": "Q9VK95_DROME", "protein_name": "Polycystic kidney disease 2", "refseq_ac": "NP_609561", "refseq_name": "polycystic kidney disease 2", "gene_name": "Pkd2", "gene_names_uniprotkb": "Pkd2; AMO; Amo; CG6504; Dmel\\CG6504; Dmel_CG6504; Dmpkd2; PKD2; TRPP2; TRPP; amo; pkd2", "gene_names_refseq": "AMO; Amo; CG6504; Dmel\\CG6504; Dmpkd2; PKD2; Pkd2; TRPP2; TRPP; amo; pkd2", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VK95", "url": "https://www.uniprot.org/uniprotkb/Q9VK95" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GVGSTRSAPPPATDPTGPPP", "down_seq": "AGKPVRDTGPSTSPRPSLRD", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr82", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "40", "end_pos": "40" }, { "start_pos": "45", "end_pos": "45" }, { "start_pos": "82", "end_pos": "82" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VKA0-1.43.43", "start_pos": 43, "end_pos": 43, "uniprot_canonical_ac": "Q9VKA0-1", "length": 151, "uniprot_id": "CROK_DROME", "protein_name": "UPAR/Ly6 domain-containing protein crok", "refseq_ac": "NP_609557", "refseq_name": "crooked", "gene_name": "crok", "gene_names_uniprotkb": "crok; CG17218", "gene_names_refseq": "BcDNA:RE65321; CG17218; Dmel\\CG17218; crok", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VKA0", "url": "https://www.uniprot.org/uniprotkb/Q9VKA0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "Q9VKA0", "url": "https://www.uniprot.org/uniprotkb/Q9VKA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PRU00498", "url": "https://prosite.expasy.org/rule/PRU00498", "database": "PROSITE-ProRule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "AIKCWDCRSDNDPKCGDPFD", "down_seq": "STLAITDCQQAPELEHLKGV", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn43", "evidence": [ { "id": "Q9VKA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9VKA0#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "43", "end_pos": "43" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VKD0-1.1191.1191", "start_pos": 1191, "end_pos": 1191, "uniprot_canonical_ac": "Q9VKD0-1", "length": 1953, "uniprot_id": "Q9VKD0_DROME", "protein_name": "WD repeat domain 81", "refseq_ac": "NP_609535", "refseq_name": "WD repeat domain 81", "gene_name": "Wdr81", "gene_names_uniprotkb": "Wdr81; CG6734; Dmel\\CG6734; Dmel_CG6734; cg6734; dWDR81", "gene_names_refseq": "CG6734; Dmel\\CG6734; Wdr81; cg6734; dWDR81", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VKD0", "url": "https://www.uniprot.org/uniprotkb/Q9VKD0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ALVPPPIGPRSPTIEIPMGP", "down_seq": "AGGIRRSFQLSAIDCDIGSR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1191", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1191", "end_pos": "1191" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VKJ8-1.180.180", "start_pos": 180, "end_pos": 180, "uniprot_canonical_ac": "Q9VKJ8-1", "length": 636, "uniprot_id": "IDUA_DROME", "protein_name": "Alpha-L-iduronidase", "refseq_ac": "NP_609489", "refseq_name": "alpha-L-iduronidase", "gene_name": "Idua", "gene_names_uniprotkb": "Idua; CG6201", "gene_names_refseq": "CG6201; D-idua; Dmel\\CG6201; IDUA; Idua", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VKJ8", "url": "https://www.uniprot.org/uniprotkb/Q9VKJ8" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "Q9VKJ8", "url": "https://www.uniprot.org/uniprotkb/Q9VKJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PRU00498", "url": "https://prosite.expasy.org/rule/PRU00498", "database": "PROSITE-ProRule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "LVNWRYETWNEPDLRGYNKQ", "down_seq": "FTAHTFLDYVQAVRRGLSKA", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn180", "evidence": [ { "id": "Q9VKJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9VKJ8#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "180", "end_pos": "180" }, { "start_pos": "268", "end_pos": "268" }, { "start_pos": "365", "end_pos": "365" }, { "start_pos": "448", "end_pos": "448" }, { "start_pos": "453", "end_pos": "453" }, { "start_pos": "483", "end_pos": "483" }, { "start_pos": "622", "end_pos": "622" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VKJ8-1.268.268", "start_pos": 268, "end_pos": 268, "uniprot_canonical_ac": "Q9VKJ8-1", "length": 636, "uniprot_id": "IDUA_DROME", "protein_name": "Alpha-L-iduronidase", "refseq_ac": "NP_609489", "refseq_name": "alpha-L-iduronidase", "gene_name": "Idua", "gene_names_uniprotkb": "Idua; CG6201", "gene_names_refseq": "CG6201; D-idua; Dmel\\CG6201; IDUA; Idua", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VKJ8", "url": "https://www.uniprot.org/uniprotkb/Q9VKJ8" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "Q9VKJ8", "url": "https://www.uniprot.org/uniprotkb/Q9VKJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PRU00498", "url": "https://prosite.expasy.org/rule/PRU00498", "database": "PROSITE-ProRule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "PIDILTFHRKGIEGTATEIV", "down_seq": "GSLSLMAKIYEEYPNLKQLP", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn268", "evidence": [ { "id": "Q9VKJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9VKJ8#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "180", "end_pos": "180" }, { "start_pos": "268", "end_pos": "268" }, { "start_pos": "365", "end_pos": "365" }, { "start_pos": "448", "end_pos": "448" }, { "start_pos": "453", "end_pos": "453" }, { "start_pos": "483", "end_pos": "483" }, { "start_pos": "622", "end_pos": "622" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VKJ8-1.365.365", "start_pos": 365, "end_pos": 365, "uniprot_canonical_ac": "Q9VKJ8-1", "length": 636, "uniprot_id": "IDUA_DROME", "protein_name": "Alpha-L-iduronidase", "refseq_ac": "NP_609489", "refseq_name": "alpha-L-iduronidase", "gene_name": "Idua", "gene_names_uniprotkb": "Idua; CG6201", "gene_names_refseq": "CG6201; D-idua; Dmel\\CG6201; IDUA; Idua", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VKJ8", "url": "https://www.uniprot.org/uniprotkb/Q9VKJ8" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "Q9VKJ8", "url": "https://www.uniprot.org/uniprotkb/Q9VKJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PRU00498", "url": "https://prosite.expasy.org/rule/PRU00498", "database": "PROSITE-ProRule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "FLSYHPHEFTQRTLLAHFRM", "down_seq": "ETKPPHSQLVQKPVYAALGM", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn365", "evidence": [ { "id": "Q9VKJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9VKJ8#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "180", "end_pos": "180" }, { "start_pos": "268", "end_pos": "268" }, { "start_pos": "365", "end_pos": "365" }, { "start_pos": "448", "end_pos": "448" }, { "start_pos": "453", "end_pos": "453" }, { "start_pos": "483", "end_pos": "483" }, { "start_pos": "622", "end_pos": "622" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VKJ8-1.448.448", "start_pos": 448, "end_pos": 448, "uniprot_canonical_ac": "Q9VKJ8-1", "length": 636, "uniprot_id": "IDUA_DROME", "protein_name": "Alpha-L-iduronidase", "refseq_ac": "NP_609489", "refseq_name": "alpha-L-iduronidase", "gene_name": "Idua", "gene_names_uniprotkb": "Idua; CG6201", "gene_names_refseq": "CG6201; D-idua; Dmel\\CG6201; IDUA; Idua", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VKJ8", "url": "https://www.uniprot.org/uniprotkb/Q9VKJ8" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "Q9VKJ8", "url": "https://www.uniprot.org/uniprotkb/Q9VKJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PRU00498", "url": "https://prosite.expasy.org/rule/PRU00498", "database": "PROSITE-ProRule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "FLSPEEAGPKMTAFHHKYTL", "down_seq": "MSIANESAFVTELLVPKETD", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn448", "evidence": [ { "id": "Q9VKJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9VKJ8#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "180", "end_pos": "180" }, { "start_pos": "268", "end_pos": "268" }, { "start_pos": "365", "end_pos": "365" }, { "start_pos": "448", "end_pos": "448" }, { "start_pos": "453", "end_pos": "453" }, { "start_pos": "483", "end_pos": "483" }, { "start_pos": "622", "end_pos": "622" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 5, "direction": "upstream", "id": "Q9VKJ8-1.453.453", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VKJ8-1.453.453", "start_pos": 453, "end_pos": 453, "uniprot_canonical_ac": "Q9VKJ8-1", "length": 636, "uniprot_id": "IDUA_DROME", "protein_name": "Alpha-L-iduronidase", "refseq_ac": "NP_609489", "refseq_name": "alpha-L-iduronidase", "gene_name": "Idua", "gene_names_uniprotkb": "Idua; CG6201", "gene_names_refseq": "CG6201; D-idua; Dmel\\CG6201; IDUA; Idua", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VKJ8", "url": "https://www.uniprot.org/uniprotkb/Q9VKJ8" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "Q9VKJ8", "url": "https://www.uniprot.org/uniprotkb/Q9VKJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PRU00498", "url": "https://prosite.expasy.org/rule/PRU00498", "database": "PROSITE-ProRule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "EAGPKMTAFHHKYTLNMSIA", "down_seq": "ESAFVTELLVPKETDPYYIW", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn453", "evidence": [ { "id": "Q9VKJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9VKJ8#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "180", "end_pos": "180" }, { "start_pos": "268", "end_pos": "268" }, { "start_pos": "365", "end_pos": "365" }, { "start_pos": "448", "end_pos": "448" }, { "start_pos": "453", "end_pos": "453" }, { "start_pos": "483", "end_pos": "483" }, { "start_pos": "622", "end_pos": "622" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 5, "direction": "downstream", "id": "Q9VKJ8-1.448.448", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VKJ8-1.483.483", "start_pos": 483, "end_pos": 483, "uniprot_canonical_ac": "Q9VKJ8-1", "length": 636, "uniprot_id": "IDUA_DROME", "protein_name": "Alpha-L-iduronidase", "refseq_ac": "NP_609489", "refseq_name": "alpha-L-iduronidase", "gene_name": "Idua", "gene_names_uniprotkb": "Idua; CG6201", "gene_names_refseq": "CG6201; D-idua; Dmel\\CG6201; IDUA; Idua", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VKJ8", "url": "https://www.uniprot.org/uniprotkb/Q9VKJ8" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "Q9VKJ8", "url": "https://www.uniprot.org/uniprotkb/Q9VKJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PRU00498", "url": "https://prosite.expasy.org/rule/PRU00498", "database": "PROSITE-ProRule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "VPKETDPYYIWQQAGSPAYP", "down_seq": "ATLREAMRRAQAPRLYKTGP", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn483", "evidence": [ { "id": "Q9VKJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9VKJ8#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "180", "end_pos": "180" }, { "start_pos": "268", "end_pos": "268" }, { "start_pos": "365", "end_pos": "365" }, { "start_pos": "448", "end_pos": "448" }, { "start_pos": "453", "end_pos": "453" }, { "start_pos": "483", "end_pos": "483" }, { "start_pos": "622", "end_pos": "622" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VKJ8-1.622.622", "start_pos": 622, "end_pos": 622, "uniprot_canonical_ac": "Q9VKJ8-1", "length": 636, "uniprot_id": "IDUA_DROME", "protein_name": "Alpha-L-iduronidase", "refseq_ac": "NP_609489", "refseq_name": "alpha-L-iduronidase", "gene_name": "Idua", "gene_names_uniprotkb": "Idua; CG6201", "gene_names_refseq": "CG6201; D-idua; Dmel\\CG6201; IDUA; Idua", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VKJ8", "url": "https://www.uniprot.org/uniprotkb/Q9VKJ8" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "Q9VKJ8", "url": "https://www.uniprot.org/uniprotkb/Q9VKJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PRU00498", "url": "https://prosite.expasy.org/rule/PRU00498", "database": "PROSITE-ProRule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "APGDKGSVNGFYKVRGVDVF", "down_seq": "ETSPYSQIVEYLEL", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn622", "evidence": [ { "id": "Q9VKJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9VKJ8#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "180", "end_pos": "180" }, { "start_pos": "268", "end_pos": "268" }, { "start_pos": "365", "end_pos": "365" }, { "start_pos": "448", "end_pos": "448" }, { "start_pos": "453", "end_pos": "453" }, { "start_pos": "483", "end_pos": "483" }, { "start_pos": "622", "end_pos": "622" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VKU2-1.597.597", "start_pos": 597, "end_pos": 597, "uniprot_canonical_ac": "Q9VKU2-1", "length": 605, "uniprot_id": "Q9VKU2_DROME", "protein_name": "Uncharacterized protein", "refseq_ac": "NP_609417", "refseq_name": "uncharacterized protein", "gene_name": "Dmel\\CG7384", "gene_names_uniprotkb": "Dmel\\CG7384; CG7384; Dmel_CG7384", "gene_names_refseq": "CG7384; Dmel\\CG7384", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VKU2", "url": "https://www.uniprot.org/uniprotkb/Q9VKU2" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "KDEPARDAAIQVASSKRFTV", "down_seq": "PARVDEQT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr597", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "597", "end_pos": "597" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VKV2-1.291.291", "start_pos": 291, "end_pos": 291, "uniprot_canonical_ac": "Q9VKV2-1", "length": 950, "uniprot_id": "Q9VKV2_DROME", "protein_name": "Alpha-mannosidase", "refseq_ac": "NP_001260350", "refseq_name": "lysosomal alpha-mannosidase I, isoform B", "gene_name": "LManI", "gene_names_uniprotkb": "LManI; CG5322; Dmel\\CG5322; Dmel_CG5322", "gene_names_refseq": "CG5322; Dmel\\CG5322; LManI", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VKV2", "url": "https://www.uniprot.org/uniprotkb/Q9VKV2" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LIKYVNDRQSTGSQVNVFYS", "down_seq": "PSCYLYELHQLKQTWPNKTE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr291", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "291", "end_pos": "291" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9VKW5-1.0.0", "start_pos": 0, "end_pos": 0, "uniprot_canonical_ac": "Q9VKW5-1", "length": 756, "uniprot_id": "Q9VKW5_DROME", "protein_name": "Prolyl endopeptidase", "refseq_ac": "NP_609397", "refseq_name": "uncharacterized protein", "gene_name": "Dmel\\CG5355", "gene_names_uniprotkb": "Dmel\\CG5355; CG5355; Dmel_CG5355", "gene_names_refseq": "CG5355; Dmel\\CG5355", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VKW5", "url": "https://www.uniprot.org/uniprotkb/Q9VKW5" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Tagging-via-substrate strategy for probing O-GlcNAc modified proteins.", "journal": "Journal of proteome research", "date": "2005", "authors": "Sprung R, Nandi A, Chen Y, Kim SC, Barma D, Falck JR, Zhao Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9VKW5", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VKW5" } ], "reference": [ { "type": "PubMed", "id": "15952742", "url": "https://glygen.org/publication/PubMed/15952742" } ] } ], "crossref": [ { "id": "15952742", "url": "https://glygen.org/publication/PubMed/15952742", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9VKW5", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VKW5", "database": "O-GlcNAc Database", "categories": [ "Other" ] } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "evidence": [ { "id": "15952742", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/15952742" }, { "id": "Q9VKW5", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9VKW5" } ] } ], "all_sites": [], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "A0A8C2LY45-1.357.357", "start_pos": 357, "end_pos": 357, "uniprot_canonical_ac": "A0A8C2LY45-1", "length": 486, "uniprot_id": "A0A8C2LY45_CRIGR", "protein_name": "Hyaluronidase", "refseq_ac": "XP_003502176", "refseq_name": "hyaluronidase-like", "gene_name": "LOC100759710", "gene_names_uniprotkb": "LOC100759710", "gene_names_refseq": "LOC100759710", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LY45", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LY45" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A8C2LY45", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LY45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR038193-2", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038193-2", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "KEACLSVQQTIQGLLGPYVF", "down_seq": "VTSAAKLCSQSLCNSHGRCV", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn357", "evidence": [ { "id": "A0A8C2LY45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LY45#ptm_processing" }, { "id": "PIRSR038193-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038193-2" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "357", "end_pos": "357" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LYQ4-1.1225.1225", "start_pos": 1225, "end_pos": 1225, "uniprot_canonical_ac": "A0A8C2LYQ4-1", "length": 1246, "uniprot_id": "A0A8C2LYQ4_CRIGR", "protein_name": "Nidogen-1", "refseq_ac": "XP_003509933", "refseq_name": "nidogen-1 isoform X1", "gene_name": "LOC100766031", "gene_names_uniprotkb": "LOC100766031", "gene_names_refseq": "LOC100766031", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LYQ4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LYQ4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PQGHNYCSVNNGGCTHLCLP", "down_seq": "PGSRTCRCPDNTLGVDCIER", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1225", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1225", "end_pos": "1225" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LYZ8-1.1251.1251", "start_pos": 1251, "end_pos": 1251, "uniprot_canonical_ac": "A0A8C2LYZ8-1", "length": 1907, "uniprot_id": "A0A8C2LYZ8_CRIGR", "protein_name": "Receptor-type tyrosine-protein phosphatase F", "refseq_ac": "XP_035294816", "refseq_name": "receptor-type tyrosine-protein phosphatase F isoform X1", "gene_name": "Ptprf", "gene_names_uniprotkb": "Ptprf", "gene_names_refseq": "Ptprf", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LYZ8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LYZ8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PMDQKRYASSPYSDEIVVQV", "down_seq": "PAQQQEEPEMLWVTGPVLAV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1251", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1251", "end_pos": "1251" }, { "start_pos": "605", "end_pos": "605" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LYZ8-1.605.605", "start_pos": 605, "end_pos": 605, "uniprot_canonical_ac": "A0A8C2LYZ8-1", "length": 1907, "uniprot_id": "A0A8C2LYZ8_CRIGR", "protein_name": "Receptor-type tyrosine-protein phosphatase F", "refseq_ac": "XP_035294816", "refseq_name": "receptor-type tyrosine-protein phosphatase F isoform X1", "gene_name": "Ptprf", "gene_names_uniprotkb": "Ptprf", "gene_names_refseq": "Ptprf", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LYZ8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LYZ8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RSDLGVGVFTPTIEARTAQS", "down_seq": "PSAPPQKVTCVSTGSTTVRV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr605", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1251", "end_pos": "1251" }, { "start_pos": "605", "end_pos": "605" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LZB0-1.500.500", "start_pos": 500, "end_pos": 500, "uniprot_canonical_ac": "A0A8C2LZB0-1", "length": 2098, "uniprot_id": "A0A8C2LZB0_CRIGR", "protein_name": "Phosphatidylinositol 4-kinase alpha", "refseq_ac": "XP_027269002", "refseq_name": "phosphatidylinositol 4-kinase alpha isoform X3", "gene_name": "Pi4ka", "gene_names_uniprotkb": "Pi4ka", "gene_names_refseq": "Pi4ka", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LZB0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LZB0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "CCLQGLGRLCERFPVVVHSV", "down_seq": "PSLRDFLVIPSPVLVKLYKY", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr500", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "500", "end_pos": "500" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LZL3-1.49.49", "start_pos": 49, "end_pos": 49, "uniprot_canonical_ac": "A0A8C2LZL3-1", "length": 1004, "uniprot_id": "A0A8C2LZL3_CRIGR", "protein_name": "RNA helicase", "refseq_ac": "XP_027249667", "refseq_name": "helicase MOV-10 isoform X2", "gene_name": "Mov10", "gene_names_uniprotkb": "Mov10", "gene_names_refseq": "Mov10", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LZL3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LZL3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ETDRERLRAIYNHDFKPSYG", "down_seq": "PAPGFSSMLYGMKIANLAFV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr49", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "49", "end_pos": "49" }, { "start_pos": "911", "end_pos": "911" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LZL3-1.911.911", "start_pos": 911, "end_pos": 911, "uniprot_canonical_ac": "A0A8C2LZL3-1", "length": 1004, "uniprot_id": "A0A8C2LZL3_CRIGR", "protein_name": "RNA helicase", "refseq_ac": "XP_027249667", "refseq_name": "helicase MOV-10 isoform X2", "gene_name": "Mov10", "gene_names_uniprotkb": "Mov10", "gene_names_refseq": "Mov10", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LZL3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LZL3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LDLDFNLGFLKNPKRFNVAV", "down_seq": "RAKALLIVVGNPLLLGHDPD", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr911", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "49", "end_pos": "49" }, { "start_pos": "911", "end_pos": "911" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LZN7-1.36.36", "start_pos": 36, "end_pos": 36, "uniprot_canonical_ac": "A0A8C2LZN7-1", "length": 434, "uniprot_id": "A0A8C2LZN7_CRIGR", "protein_name": "Fucosyltransferase", "refseq_ac": "XP_027266625", "refseq_name": "alpha-(1,3)-fucosyltransferase 4 isoform X2", "gene_name": "Fut4", "gene_names_uniprotkb": "Fut4", "gene_names_refseq": "Fut4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LZN7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LZN7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PSRSVDAWRAEAAAPGPCMG", "down_seq": "PGTRQRARVRPGWRLRRSSS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr36", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "36", "end_pos": "36" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LZT7-1.1199.1199", "start_pos": 1199, "end_pos": 1199, "uniprot_canonical_ac": "A0A8C2LZT7-1", "length": 1215, "uniprot_id": "A0A8C2LZT7_CRIGR", "protein_name": "peptidylprolyl isomerase", "refseq_ac": "XP_007642264", "refseq_name": "FK506-binding protein 15 isoform X5", "gene_name": "Fkbp15", "gene_names_uniprotkb": "Fkbp15", "gene_names_refseq": "Fkbp15", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LZT7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LZT7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "IVQPEEEDEDEVSMKGRPPP", "down_seq": "PLFGDDDDDDDIDWLG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1199", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1199", "end_pos": "1199" }, { "start_pos": "276", "end_pos": "276" }, { "start_pos": "68", "end_pos": "68" }, { "start_pos": "958", "end_pos": "958" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LZT7-1.276.276", "start_pos": 276, "end_pos": 276, "uniprot_canonical_ac": "A0A8C2LZT7-1", "length": 1215, "uniprot_id": "A0A8C2LZT7_CRIGR", "protein_name": "peptidylprolyl isomerase", "refseq_ac": "XP_007642264", "refseq_name": "FK506-binding protein 15 isoform X5", "gene_name": "Fkbp15", "gene_names_uniprotkb": "Fkbp15", "gene_names_refseq": "Fkbp15", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LZT7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LZT7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "IIIPSACAAGSEGVIGWIQP", "down_seq": "DSILVFEVEVRRVKFARDSG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr276", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1199", "end_pos": "1199" }, { "start_pos": "276", "end_pos": "276" }, { "start_pos": "68", "end_pos": "68" }, { "start_pos": "958", "end_pos": "958" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LZT7-1.68.68", "start_pos": 68, "end_pos": 68, "uniprot_canonical_ac": "A0A8C2LZT7-1", "length": 1215, "uniprot_id": "A0A8C2LZT7_CRIGR", "protein_name": "peptidylprolyl isomerase", "refseq_ac": "XP_007642264", "refseq_name": "FK506-binding protein 15 isoform X5", "gene_name": "Fkbp15", "gene_names_uniprotkb": "Fkbp15", "gene_names_refseq": "Fkbp15", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LZT7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LZT7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "KKGQAVAATGNQTAPKPATA", "down_seq": "PGTSSVLFATAVHAYRYVNG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr68", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1199", "end_pos": "1199" }, { "start_pos": "276", "end_pos": "276" }, { "start_pos": "68", "end_pos": "68" }, { "start_pos": "958", "end_pos": "958" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LZT7-1.958.958", "start_pos": 958, "end_pos": 958, "uniprot_canonical_ac": "A0A8C2LZT7-1", "length": 1215, "uniprot_id": "A0A8C2LZT7_CRIGR", "protein_name": "peptidylprolyl isomerase", "refseq_ac": "XP_007642264", "refseq_name": "FK506-binding protein 15 isoform X5", "gene_name": "Fkbp15", "gene_names_uniprotkb": "Fkbp15", "gene_names_refseq": "Fkbp15", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LZT7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LZT7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SSEEEEDKPLRPSLEQPGPA", "down_seq": "PGLSPAPPSRETQEVPKVLS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr958", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1199", "end_pos": "1199" }, { "start_pos": "276", "end_pos": "276" }, { "start_pos": "68", "end_pos": "68" }, { "start_pos": "958", "end_pos": "958" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LZX4-1.184.184", "start_pos": 184, "end_pos": 184, "uniprot_canonical_ac": "A0A8C2LZX4-1", "length": 1095, "uniprot_id": "A0A8C2LZX4_CRIGR", "protein_name": "Adenylate cyclase type 2", "refseq_ac": "XP_027255918", "refseq_name": "adenylate cyclase type 2 isoform X2", "gene_name": "Adcy2", "gene_names_uniprotkb": "Adcy2", "gene_names_refseq": "Adcy2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LZX4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LZX4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "IASVLTSSSHTIVLSVYLSA", "down_seq": "PGAKEHLSWQILANVIIFIC", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr184", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "184", "end_pos": "184" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M075-1.403.403", "start_pos": 403, "end_pos": 403, "uniprot_canonical_ac": "A0A8C2M075-1", "length": 1004, "uniprot_id": "A0A8C2M075_CRIGR", "protein_name": "DNA topoisomerase", "refseq_ac": "XP_027283074", "refseq_name": "DNA topoisomerase 3-alpha isoform X1", "gene_name": "Top3a", "gene_names_uniprotkb": "Top3a", "gene_names_refseq": "Top3a", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M075", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M075" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QTLDPHWGAFAQNILERGGP", "down_seq": "PRNGNKSDQAHPPIHPTKYT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr403", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "403", "end_pos": "403" }, { "start_pos": "805", "end_pos": "805" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M075-1.805.805", "start_pos": 805, "end_pos": 805, "uniprot_canonical_ac": "A0A8C2M075-1", "length": 1004, "uniprot_id": "A0A8C2M075_CRIGR", "protein_name": "DNA topoisomerase", "refseq_ac": "XP_027283074", "refseq_name": "DNA topoisomerase 3-alpha isoform X1", "gene_name": "Top3a", "gene_names_uniprotkb": "Top3a", "gene_names_refseq": "Top3a", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M075", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M075" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PLVNRHTGSSKAMAETFPPP", "down_seq": "PAGESNSVICNCGQEAVLLT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr805", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "403", "end_pos": "403" }, { "start_pos": "805", "end_pos": "805" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M0J5-1.339.339", "start_pos": 339, "end_pos": 339, "uniprot_canonical_ac": "A0A8C2M0J5-1", "length": 781, "uniprot_id": "A0A8C2M0J5_CRIGR", "protein_name": "Cysteine-rich protein 2-binding protein", "refseq_ac": "XP_003496515", "refseq_name": "cysteine-rich protein 2-binding protein isoform X1", "gene_name": "Kat14", "gene_names_uniprotkb": "Kat14", "gene_names_refseq": "Kat14", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M0J5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M0J5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DRTPLTSPSPSPSLDFSAPG", "down_seq": "PASHSATPSLLSEADLIPDV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr339", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "339", "end_pos": "339" }, { "start_pos": "346", "end_pos": "346" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 7, "direction": "upstream", "id": "A0A8C2M0J5-1.346.346", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M0J5-1.346.346", "start_pos": 346, "end_pos": 346, "uniprot_canonical_ac": "A0A8C2M0J5-1", "length": 781, "uniprot_id": "A0A8C2M0J5_CRIGR", "protein_name": "Cysteine-rich protein 2-binding protein", "refseq_ac": "XP_003496515", "refseq_name": "cysteine-rich protein 2-binding protein isoform X1", "gene_name": "Kat14", "gene_names_uniprotkb": "Kat14", "gene_names_refseq": "Kat14", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M0J5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M0J5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PSPSPSLDFSAPGTPASHSA", "down_seq": "PSLLSEADLIPDVMPPQALF", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr346", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "339", "end_pos": "339" }, { "start_pos": "346", "end_pos": "346" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 7, "direction": "downstream", "id": "A0A8C2M0J5-1.339.339", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M102-1.1345.1345", "start_pos": 1345, "end_pos": 1345, "uniprot_canonical_ac": "A0A8C2M102-1", "length": 1814, "uniprot_id": "A0A8C2M102_CRIGR", "protein_name": "Afadin", "refseq_ac": "XP_027256954", "refseq_name": "afadin isoform X11", "gene_name": "Afdn", "gene_names_uniprotkb": "Afdn", "gene_names_refseq": "Afdn", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M102", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M102" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ASTLTKSGPGRWKTPAAVLP", "down_seq": "PVAVSQPIRTDLPPPPPPPP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1345", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1345", "end_pos": "1345" }, { "start_pos": "448", "end_pos": "448" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M102-1.448.448", "start_pos": 448, "end_pos": 448, "uniprot_canonical_ac": "A0A8C2M102-1", "length": 1814, "uniprot_id": "A0A8C2M102_CRIGR", "protein_name": "Afadin", "refseq_ac": "XP_027256954", "refseq_name": "afadin isoform X11", "gene_name": "Afdn", "gene_names_uniprotkb": "Afdn", "gene_names_refseq": "Afdn", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M102", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M102" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GPGIQPHHCDLTNMDGVVTV", "down_seq": "PRSMDAETYVDGQRISETTM", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr448", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1345", "end_pos": "1345" }, { "start_pos": "448", "end_pos": "448" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M1B9-1.96.96", "start_pos": 96, "end_pos": 96, "uniprot_canonical_ac": "A0A8C2M1B9-1", "length": 173, "uniprot_id": "A0A8C2M1B9_CRIGR", "protein_name": "Tumor necrosis factor ligand superfamily member 18", "refseq_ac": "XP_003497726", "refseq_name": "tumor necrosis factor ligand superfamily member 18", "gene_name": "Tnfsf18", "gene_names_uniprotkb": "Tnfsf18", "gene_names_refseq": "Tnfsf18", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M1B9", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M1B9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TSDGKLEILQDGVYLIYGRV", "down_seq": "PVNKEDIKNSADFIVELVKE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr96", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "96", "end_pos": "96" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M1J0-1.184.184", "start_pos": 184, "end_pos": 184, "uniprot_canonical_ac": "A0A8C2M1J0-1", "length": 404, "uniprot_id": "A0A8C2M1J0_CRIGR", "protein_name": "Ethanolamine-phosphate cytidylyltransferase", "refseq_ac": "XP_007652319", "refseq_name": "ethanolamine-phosphate cytidylyltransferase isoform X1", "gene_name": "Pcyt2", "gene_names_uniprotkb": "Pcyt2", "gene_names_refseq": "Pcyt2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M1J0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M1J0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QEMSSEYREYADSFGKPPHP", "down_seq": "PAGDTLSSEVSSQCPGGQNP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr184", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "184", "end_pos": "184" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M1Q6-1.483.483", "start_pos": 483, "end_pos": 483, "uniprot_canonical_ac": "A0A8C2M1Q6-1", "length": 688, "uniprot_id": "A0A8C2M1Q6_CRIGR", "protein_name": "Junctophilin", "refseq_ac": "XP_027279303", "refseq_name": "junctophilin-2", "gene_name": "Jph2", "gene_names_uniprotkb": "Jph2", "gene_names_refseq": "Jph2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M1Q6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M1Q6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PQLHERETPQPEGGPPSPAG", "down_seq": "PPQPKRPRPAASKDGLLSPG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr483", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "483", "end_pos": "483" }, { "start_pos": "518", "end_pos": "518" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M1Q6-1.518.518", "start_pos": 518, "end_pos": 518, "uniprot_canonical_ac": "A0A8C2M1Q6-1", "length": 688, "uniprot_id": "A0A8C2M1Q6_CRIGR", "protein_name": "Junctophilin", "refseq_ac": "XP_027279303", "refseq_name": "junctophilin-2", "gene_name": "Jph2", "gene_names_uniprotkb": "Jph2", "gene_names_refseq": "Jph2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M1Q6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M1Q6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GLLSPGAWNGEPGGEGSRPV", "down_seq": "PSDGAGRRSPARPVSEHMAI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr518", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "483", "end_pos": "483" }, { "start_pos": "518", "end_pos": "518" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M1R8-1.739.739", "start_pos": 739, "end_pos": 739, "uniprot_canonical_ac": "A0A8C2M1R8-1", "length": 785, "uniprot_id": "A0A8C2M1R8_CRIGR", "protein_name": "Transcription factor Sp1 isoform X3", "refseq_ac": "XP_027252496", "refseq_name": "transcription factor Sp1 isoform X3", "gene_name": "Sp1", "gene_names_uniprotkb": "Sp1", "gene_names_refseq": "Sp1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M1R8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M1R8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LSVGTLPLDSGAGSEGSGTA", "down_seq": "PSALIATNMVAMEAICPEGI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr739", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "739", "end_pos": "739" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M2G0-1.501.501", "start_pos": 501, "end_pos": 501, "uniprot_canonical_ac": "A0A8C2M2G0-1", "length": 811, "uniprot_id": "A0A8C2M2G0_CRIGR", "protein_name": "F-BAR domain only protein 2", "refseq_ac": "XP_007642450", "refseq_name": "F-BAR domain only protein 2 isoform X1", "gene_name": "Fcho2", "gene_names_uniprotkb": "Fcho2", "gene_names_refseq": "Fcho2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M2G0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M2G0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "INEIPRPFSPPVTSNTSPPP", "down_seq": "APLARAESSSSISSSASLSA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr501", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "501", "end_pos": "501" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M2K2-1.282.282", "start_pos": 282, "end_pos": 282, "uniprot_canonical_ac": "A0A8C2M2K2-1", "length": 393, "uniprot_id": "A0A8C2M2K2_CRIGR", "protein_name": "Telomeric repeat-binding factor 2-interacting protein 1", "refseq_ac": "XP_027261867", "refseq_name": "telomeric repeat-binding factor 2-interacting protein 1 isoform X1", "gene_name": "Terf2ip", "gene_names_uniprotkb": "Terf2ip", "gene_names_refseq": "Terf2ip", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M2K2", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M2K2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VVGESPDFEIHITMCDDDPP", "down_seq": "PEEDSETQPDEEEEEPKVST", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr282", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "282", "end_pos": "282" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M2T1-1.423.423", "start_pos": 423, "end_pos": 423, "uniprot_canonical_ac": "A0A8C2M2T1-1", "length": 607, "uniprot_id": "A0A8C2M2T1_CRIGR", "protein_name": "Matrix metalloproteinase-16 isoform X2", "refseq_ac": "XP_027259368", "refseq_name": "matrix metalloproteinase-16 isoform X2", "gene_name": "Mmp16", "gene_names_uniprotkb": "Mmp16", "gene_names_refseq": "Mmp16", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M2T1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M2T1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A8C2M2T1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M2T1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "site_seq": "Y", "start_aa": "Y", "up_seq": "FVFFKGNKYWVFKDTTLQPG", "down_seq": "PHDLITLGNGIPPHGIDSAI", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine; by PKDCC", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M2T1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M2T1" } ], "site_lbl": "Tyr423" } ], "all_sites": [ { "type": "phosphorylation", "site_list": [ { "start_pos": "423", "end_pos": "423" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M357-1.223.223", "start_pos": 223, "end_pos": 223, "uniprot_canonical_ac": "A0A8C2M357-1", "length": 622, "uniprot_id": "A0A8C2M357_CRIGR", "protein_name": "Zinc finger protein 653", "refseq_ac": "XP_027267403", "refseq_name": "zinc finger protein 653 isoform X2", "gene_name": "Znf653", "gene_names_uniprotkb": "Znf653", "gene_names_refseq": "Znf653", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M357", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M357" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SDSEEPPEAQPAKAPAAAAV", "down_seq": "PASPACSSGLITQEGVHIPF", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr223", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "223", "end_pos": "223" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M3J8-1.371.371", "start_pos": 371, "end_pos": 371, "uniprot_canonical_ac": "A0A8C2M3J8-1", "length": 476, "uniprot_id": "A0A8C2M3J8_CRIGR", "protein_name": "Stromelysin-2", "refseq_ac": "XP_027270983", "refseq_name": "stromelysin-2", "gene_name": "Mmp10", "gene_names_uniprotkb": "Mmp10", "gene_names_refseq": "Mmp10", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M3J8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M3J8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A8C2M3J8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M3J8", "database": "UniProtKB", "categories": [ "Protein" ] } ], "site_seq": "Y", "start_aa": "Y", "up_seq": "VFIFKGNQFWAVRGNEVQAG", "down_seq": "PKALHTLGFPPTVKKIDAAV", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine; by PKDCC", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M3J8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M3J8" } ], "site_lbl": "Tyr371" } ], "all_sites": [ { "type": "phosphorylation", "site_list": [ { "start_pos": "371", "end_pos": "371" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M5G2-1.106.106", "start_pos": 106, "end_pos": 106, "uniprot_canonical_ac": "A0A8C2M5G2-1", "length": 1097, "uniprot_id": "A0A8C2M5G2_CRIGR", "protein_name": "Mitogen-activated protein kinase kinase kinase", "refseq_ac": "XP_035301582", "refseq_name": "mitogen-activated protein kinase kinase kinase 9 isoform X3", "gene_name": "Map3k9", "gene_names_uniprotkb": "Map3k9", "gene_names_refseq": "Map3k9", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M5G2", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M5G2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EGWWTGQLNQRVGIFPSNYV", "down_seq": "PRSAFSSRCQPGAEDPSCYP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr106", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "106", "end_pos": "106" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M4I1-1.658.658", "start_pos": 658, "end_pos": 658, "uniprot_canonical_ac": "A0A8C2M4I1-1", "length": 1127, "uniprot_id": "A0A8C2M4I1_CRIGR", "protein_name": "E3 ubiquitin-protein ligase TRIM33", "refseq_ac": "XP_003505868", "refseq_name": "E3 ubiquitin-protein ligase TRIM33 isoform X1", "gene_name": "Trim33", "gene_names_uniprotkb": "Trim33", "gene_names_refseq": "Trim33", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M4I1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M4I1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "NPINPTSPTTATMANANRGP", "down_seq": "SPSVTAIELIPSVTNPENLP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr658", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "658", "end_pos": "658" }, { "start_pos": "97", "end_pos": "97" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M4I1-1.97.97", "start_pos": 97, "end_pos": 97, "uniprot_canonical_ac": "A0A8C2M4I1-1", "length": 1127, "uniprot_id": "A0A8C2M4I1_CRIGR", "protein_name": "E3 ubiquitin-protein ligase TRIM33", "refseq_ac": "XP_003505868", "refseq_name": "E3 ubiquitin-protein ligase TRIM33 isoform X1", "gene_name": "Trim33", "gene_names_uniprotkb": "Trim33", "gene_names_refseq": "Trim33", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M4I1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M4I1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PAASVPAASVGSTVPGGAAS", "down_seq": "PAPAAASAPAPGPSSGPPLG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr97", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "658", "end_pos": "658" }, { "start_pos": "97", "end_pos": "97" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M3S5-1.1001.1001", "start_pos": 1001, "end_pos": 1001, "uniprot_canonical_ac": "A0A8C2M3S5-1", "length": 1531, "uniprot_id": "A0A8C2M3S5_CRIGR", "protein_name": "Slit homolog 1 protein", "refseq_ac": "XP_027263136", "refseq_name": "slit homolog 1 protein", "gene_name": "Slit1", "gene_names_uniprotkb": "Slit1", "gene_names_refseq": "Slit1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M3S5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M3S5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TQEGEGAGFTCSCPSGFEGP", "down_seq": "CGVNTDDCVKHACVNGGVCV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1001", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1001", "end_pos": "1001" }, { "start_pos": "1354", "end_pos": "1354" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M3S5-1.1354.1354", "start_pos": 1354, "end_pos": 1354, "uniprot_canonical_ac": "A0A8C2M3S5-1", "length": 1531, "uniprot_id": "A0A8C2M3S5_CRIGR", "protein_name": "Slit homolog 1 protein", "refseq_ac": "XP_027263136", "refseq_name": "slit homolog 1 protein", "gene_name": "Slit1", "gene_names_uniprotkb": "Slit1", "gene_names_refseq": "Slit1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M3S5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M3S5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PGCEPCRKLYCLHGICQPNA", "down_seq": "PGPVCHCEAGWGGLHCDQPV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1354", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1001", "end_pos": "1001" }, { "start_pos": "1354", "end_pos": "1354" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M431-1.8.8", "start_pos": 8, "end_pos": 8, "uniprot_canonical_ac": "A0A8C2M431-1", "length": 465, "uniprot_id": "A0A8C2M431_CRIGR", "protein_name": "Melanopsin", "refseq_ac": "XP_035309101", "refseq_name": "melanopsin isoform X1", "gene_name": "Opn4", "gene_names_uniprotkb": "Opn4", "gene_names_refseq": "Opn4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M431", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M431" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MDSPSGP", "down_seq": "GPPGLTQGPSFMASTALQGH", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr8", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "8", "end_pos": "8" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M465-1.298.298", "start_pos": 298, "end_pos": 298, "uniprot_canonical_ac": "A0A8C2M465-1", "length": 939, "uniprot_id": "A0A8C2M465_CRIGR", "protein_name": "Calcium-activated chloride channel regulator 2", "refseq_ac": "XP_035306433", "refseq_name": "calcium-activated chloride channel regulator 2", "gene_name": "LOC100754285", "gene_names_uniprotkb": "LOC100754285", "gene_names_refseq": "LOC100754285", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M465", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M465" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DSDDISHSPPVHGAELPPPP", "down_seq": "CSLLQAGDKVICLVIDVSRK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr298", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "298", "end_pos": "298" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M483-1.66.66", "start_pos": 66, "end_pos": 66, "uniprot_canonical_ac": "A0A8C2M483-1", "length": 331, "uniprot_id": "A0A8C2M483_CRIGR", "protein_name": "Mitochondrial fission regulator", "refseq_ac": "XP_027259286", "refseq_name": "mitochondrial fission regulator 1 isoform X2", "gene_name": "Mtfr1", "gene_names_uniprotkb": "Mtfr1", "gene_names_refseq": "Mtfr1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M483", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M483" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LIQCPRVQFQLTSHATEWSP", "down_seq": "PPGDDVVASFADVGWVAAEE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr66", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "66", "end_pos": "66" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M4U0-1.370.370", "start_pos": 370, "end_pos": 370, "uniprot_canonical_ac": "A0A8C2M4U0-1", "length": 522, "uniprot_id": "A0A8C2M4U0_CRIGR", "protein_name": "Leucine-rich repeat transmembrane neuronal protein 1", "refseq_ac": "XP_035304499", "refseq_name": "leucine-rich repeat transmembrane neuronal protein 1", "gene_name": "Lrrtm1", "gene_names_uniprotkb": "Lrrtm1", "gene_names_refseq": "Lrrtm1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M4U0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M4U0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GEDVLDAVYAFHLCEDGAEP", "down_seq": "SGHLLSAVTNRSDLAPPESS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr370", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "370", "end_pos": "370" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M4Y0-1.208.208", "start_pos": 208, "end_pos": 208, "uniprot_canonical_ac": "A0A8C2M4Y0-1", "length": 293, "uniprot_id": "A0A8C2M4Y0_CRIGR", "protein_name": "Exosome complex component RRP4", "refseq_ac": "XP_003513167", "refseq_name": "exosome complex component RRP4 isoform X1", "gene_name": "Exosc2", "gene_names_uniprotkb": "Exosc2", "gene_names_refseq": "Exosc2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M4Y0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M4Y0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DLPCGASVILGNNGFIWIYP", "down_seq": "PEHKDEDAGGFIANLEPVAL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr208", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "208", "end_pos": "208" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M4Y2-1.259.259", "start_pos": 259, "end_pos": 259, "uniprot_canonical_ac": "A0A8C2M4Y2-1", "length": 325, "uniprot_id": "A0A8C2M4Y2_CRIGR", "protein_name": "Cytochrome c1, heme protein, mitochondrial", "refseq_ac": "XP_027260081", "refseq_name": "cytochrome c1, heme protein, mitochondrial", "gene_name": "LOC100766032", "gene_names_uniprotkb": "LOC100766032", "gene_names_refseq": "LOC100766032", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M4Y2", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M4Y2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GQAIGMAPPIYNEVLEYDDG", "down_seq": "PATMSQIAKDVATFLRWASE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr259", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "259", "end_pos": "259" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M5G9-1.59.59", "start_pos": 59, "end_pos": 59, "uniprot_canonical_ac": "A0A8C2M5G9-1", "length": 397, "uniprot_id": "A0A8C2M5G9_CRIGR", "protein_name": "Neuroplastin", "refseq_ac": "XP_027270708", "refseq_name": "neuroplastin isoform X2", "gene_name": "Nptn", "gene_names_uniprotkb": "Nptn", "gene_names_refseq": "Nptn", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M5G9", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M5G9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SETKLTGDAFELYCDVVGSP", "down_seq": "PEIQWWYAEVNRAESFRQLW", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr59", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "59", "end_pos": "59" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M5M4-1.367.367", "start_pos": 367, "end_pos": 367, "uniprot_canonical_ac": "A0A8C2M5M4-1", "length": 460, "uniprot_id": "A0A8C2M5M4_CRIGR", "protein_name": "DNA polymerase subunit gamma-2", "refseq_ac": "XP_027283597", "refseq_name": "DNA polymerase subunit gamma-2, mitochondrial isoform X2", "gene_name": "Polg2", "gene_names_uniprotkb": "Polg2", "gene_names_refseq": "Polg2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M5M4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M5M4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LKLHPCLAPIKVALDVGKGP", "down_seq": "AELRQVCQGLLNEFLENGIS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr367", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "367", "end_pos": "367" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M5N0-1.311.311", "start_pos": 311, "end_pos": 311, "uniprot_canonical_ac": "A0A8C2M5N0-1", "length": 337, "uniprot_id": "A0A8C2M5N0_CRIGR", "protein_name": "Serine/threonine-protein phosphatase", "refseq_ac": "XP_027269862", "refseq_name": "serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X2", "gene_name": "Ppp1cc", "gene_names_uniprotkb": "Ppp1cc", "gene_names_refseq": "Ppp1cc", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M5N0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M5N0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "CSFQILKPAEKKKPNATRPV", "down_seq": "PPRVGSGLNPSIQKASNYRN", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr311", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "311", "end_pos": "311" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M5R2-1.747.747", "start_pos": 747, "end_pos": 747, "uniprot_canonical_ac": "A0A8C2M5R2-1", "length": 792, "uniprot_id": "A0A8C2M5R2_CRIGR", "protein_name": "Kinesin-like protein", "refseq_ac": "XP_027259996", "refseq_name": "kinesin-like protein KIFC2 isoform X3", "gene_name": "Kifc2", "gene_names_uniprotkb": "Kifc2", "gene_names_refseq": "Kifc2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M5R2", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M5R2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QRVGQVELGPARRRRAPRSG", "down_seq": "PSSLSTDTPLTGTSCTPTPS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr747", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "747", "end_pos": "747" }, { "start_pos": "765", "end_pos": "765" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 18, "direction": "upstream", "id": "A0A8C2M5R2-1.765.765", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M5R2-1.765.765", "start_pos": 765, "end_pos": 765, "uniprot_canonical_ac": "A0A8C2M5R2-1", "length": 792, "uniprot_id": "A0A8C2M5R2_CRIGR", "protein_name": "Kinesin-like protein", "refseq_ac": "XP_027259996", "refseq_name": "kinesin-like protein KIFC2 isoform X3", "gene_name": "Kifc2", "gene_names_uniprotkb": "Kifc2", "gene_names_refseq": "Kifc2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M5R2", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M5R2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SGTPSSLSTDTPLTGTSCTP", "down_seq": "PSPGSPPSPGPNSCSGLTLE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr765", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "747", "end_pos": "747" }, { "start_pos": "765", "end_pos": "765" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 18, "direction": "downstream", "id": "A0A8C2M5R2-1.747.747", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M6U9-1.96.96", "start_pos": 96, "end_pos": 96, "uniprot_canonical_ac": "A0A8C2M6U9-1", "length": 399, "uniprot_id": "A0A8C2M6U9_CRIGR", "protein_name": "Homeobox protein aristaless-like 4", "refseq_ac": "XP_035303066", "refseq_name": "homeobox protein aristaless-like 4 isoform X2", "gene_name": "Alx4", "gene_names_uniprotkb": "Alx4", "gene_names_refseq": "Alx4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M6U9", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M6U9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PLESSAGARGSFNKFQPQPP", "down_seq": "PQPPPAPPAPPAHLYLQRGA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr96", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "96", "end_pos": "96" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M6Z6-1.580.580", "start_pos": 580, "end_pos": 580, "uniprot_canonical_ac": "A0A8C2M6Z6-1", "length": 923, "uniprot_id": "A0A8C2M6Z6_CRIGR", "protein_name": "Alpha-aminoadipic semialdehyde synthase, mitochondrial", "refseq_ac": "XP_007643548", "refseq_name": "alpha-aminoadipic semialdehyde synthase, mitochondrial", "gene_name": "Aass", "gene_names_uniprotkb": "Aass", "gene_names_refseq": "Aass", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M6Z6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M6Z6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PVVAKACISNRVNMITASYI", "down_seq": "PAMKELEKSVDDAGITIIGE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr580", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "580", "end_pos": "580" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M726-1.45.45", "start_pos": 45, "end_pos": 45, "uniprot_canonical_ac": "A0A8C2M726-1", "length": 198, "uniprot_id": "A0A8C2M726_CRIGR", "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 3", "refseq_ac": "XP_027286703", "refseq_name": "biogenesis of lysosome-related organelles complex 1 subunit 3", "gene_name": "LOC113837286", "gene_names_uniprotkb": "LOC113837286", "gene_names_refseq": "LOC113837286", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M726", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M726" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EPSASSSSEEEELYLGPSGP", "down_seq": "RGRPTGLRVAGEAAETDSEA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr45", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "45", "end_pos": "45" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M7A9-1.882.882", "start_pos": 882, "end_pos": 882, "uniprot_canonical_ac": "A0A8C2M7A9-1", "length": 897, "uniprot_id": "A0A8C2M7A9_CRIGR", "protein_name": "Echinoderm microtubule-associated protein-like 3", "refseq_ac": "XP_027264130", "refseq_name": "echinoderm microtubule-associated protein-like 3 isoform X4", "gene_name": "Eml3", "gene_names_uniprotkb": "Eml3", "gene_names_refseq": "Eml3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M7A9", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M7A9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DASIFQWRVLGAGGSGPSPV", "down_seq": "PSRTPSLSPASSLDV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr882", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "882", "end_pos": "882" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M7F7-1.1094.1094", "start_pos": 1094, "end_pos": 1094, "uniprot_canonical_ac": "A0A8C2M7F7-1", "length": 1656, "uniprot_id": "A0A8C2M7F7_CRIGR", "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 7", "refseq_ac": "XP_027266763", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform X1", "gene_name": "Adamts7", "gene_names_uniprotkb": "Adamts7", "gene_names_refseq": "Adamts7", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M7F7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M7F7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GWTAPPHIRLTEPPSDTPVP", "down_seq": "AGTPGVKEDGVQGGWSPSPS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1094", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1094", "end_pos": "1094" }, { "start_pos": "1097", "end_pos": "1097" }, { "start_pos": "1296", "end_pos": "1296" }, { "start_pos": "1478", "end_pos": "1478" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 3, "direction": "upstream", "id": "A0A8C2M7F7-1.1097.1097", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M7F7-1.1097.1097", "start_pos": 1097, "end_pos": 1097, "uniprot_canonical_ac": "A0A8C2M7F7-1", "length": 1656, "uniprot_id": "A0A8C2M7F7_CRIGR", "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 7", "refseq_ac": "XP_027266763", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform X1", "gene_name": "Adamts7", "gene_names_uniprotkb": "Adamts7", "gene_names_refseq": "Adamts7", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M7F7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M7F7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "APPHIRLTEPPSDTPVPTAG", "down_seq": "PGVKEDGVQGGWSPSPSLSQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1097", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1094", "end_pos": "1094" }, { "start_pos": "1097", "end_pos": "1097" }, { "start_pos": "1296", "end_pos": "1296" }, { "start_pos": "1478", "end_pos": "1478" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 3, "direction": "downstream", "id": "A0A8C2M7F7-1.1094.1094", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M7F7-1.1296.1296", "start_pos": 1296, "end_pos": 1296, "uniprot_canonical_ac": "A0A8C2M7F7-1", "length": 1656, "uniprot_id": "A0A8C2M7F7_CRIGR", "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 7", "refseq_ac": "XP_027266763", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform X1", "gene_name": "Adamts7", "gene_names_uniprotkb": "Adamts7", "gene_names_refseq": "Adamts7", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M7F7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M7F7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TVPGIWDRDSPLEPGTPTFS", "down_seq": "PGLGSQNPKTVALPGTLFLT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1296", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1094", "end_pos": "1094" }, { "start_pos": "1097", "end_pos": "1097" }, { "start_pos": "1296", "end_pos": "1296" }, { "start_pos": "1478", "end_pos": "1478" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M7F7-1.1478.1478", "start_pos": 1478, "end_pos": 1478, "uniprot_canonical_ac": "A0A8C2M7F7-1", "length": 1656, "uniprot_id": "A0A8C2M7F7_CRIGR", "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 7", "refseq_ac": "XP_027266763", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform X1", "gene_name": "Adamts7", "gene_names_uniprotkb": "Adamts7", "gene_names_refseq": "Adamts7", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M7F7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M7F7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QCVDTRDLRPLRPFHCQPGP", "down_seq": "KPPTRQLCGTQPCLSWYTSS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1478", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1094", "end_pos": "1094" }, { "start_pos": "1097", "end_pos": "1097" }, { "start_pos": "1296", "end_pos": "1296" }, { "start_pos": "1478", "end_pos": "1478" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M7F9-1.761.761", "start_pos": 761, "end_pos": 761, "uniprot_canonical_ac": "A0A8C2M7F9-1", "length": 1011, "uniprot_id": "A0A8C2M7F9_CRIGR", "protein_name": "Rap guanine nucleotide exchange factor 4", "refseq_ac": "XP_027275986", "refseq_name": "rap guanine nucleotide exchange factor 4 isoform X6", "gene_name": "LOC100774346", "gene_names_uniprotkb": "LOC100774346", "gene_names_refseq": "LOC100774346", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M7F9", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M7F9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "FACPREQFDSLTPLPEQEGP", "down_seq": "TGTVGTFELMSSKDLAYQMT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr761", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "761", "end_pos": "761" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M7G0-1.40.40", "start_pos": 40, "end_pos": 40, "uniprot_canonical_ac": "A0A8C2M7G0-1", "length": 1083, "uniprot_id": "A0A8C2M7G0_CRIGR", "protein_name": "Solute carrier family 12 member 7 isoform X3", "refseq_ac": "XP_027255948", "refseq_name": "solute carrier family 12 member 7 isoform X3", "gene_name": "Slc12a7", "gene_names_uniprotkb": "Slc12a7", "gene_names_refseq": "Slc12a7", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M7G0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M7G0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EAAERTEEPGSPESADPACP", "down_seq": "SGDGNPRENSPFINNVEVER", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr40", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "40", "end_pos": "40" }, { "start_pos": "973", "end_pos": "973" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M7G0-1.973.973", "start_pos": 973, "end_pos": 973, "uniprot_canonical_ac": "A0A8C2M7G0-1", "length": 1083, "uniprot_id": "A0A8C2M7G0_CRIGR", "protein_name": "Solute carrier family 12 member 7 isoform X3", "refseq_ac": "XP_027255948", "refseq_name": "solute carrier family 12 member 7 isoform X3", "gene_name": "Slc12a7", "gene_names_uniprotkb": "Slc12a7", "gene_names_refseq": "Slc12a7", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M7G0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M7G0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "IHDRNTASHTTAAARTQAPP", "down_seq": "PDKVQMTWTKEKLIAEKHRN", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr973", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "40", "end_pos": "40" }, { "start_pos": "973", "end_pos": "973" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M7G5-1.351.351", "start_pos": 351, "end_pos": 351, "uniprot_canonical_ac": "A0A8C2M7G5-1", "length": 462, "uniprot_id": "A0A8C2M7G5_CRIGR", "protein_name": "Protein naked cuticle homolog", "refseq_ac": "XP_027255950", "refseq_name": "protein naked cuticle homolog 2 isoform X2", "gene_name": "Nkd2", "gene_names_uniprotkb": "Nkd2", "gene_names_refseq": "Nkd2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M7G5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M7G5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LKGQEKQFLRSPKGPGKPLG", "down_seq": "PGSSKPGKTLSYCLQAVPLP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr351", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "351", "end_pos": "351" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M883-1.647.647", "start_pos": 647, "end_pos": 647, "uniprot_canonical_ac": "A0A8C2M883-1", "length": 786, "uniprot_id": "A0A8C2M883_CRIGR", "protein_name": "Rho GTPase-activating protein 10", "refseq_ac": "XP_027266349", "refseq_name": "rho GTPase-activating protein 10 isoform X4", "gene_name": "Arhgap10", "gene_names_uniprotkb": "Arhgap10", "gene_names_refseq": "Arhgap10", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M883", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M883" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SPVKEDTPTSSQDSLSTPSP", "down_seq": "TSAAHGPSGPDGNHLAADGG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr647", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M8E3-1.27.27", "start_pos": 27, "end_pos": 27, "uniprot_canonical_ac": "A0A8C2M8E3-1", "length": 335, "uniprot_id": "A0A8C2M8E3_CRIGR", "protein_name": "BRISC and BRCA1-A complex member 1", "refseq_ac": "XP_027250616", "refseq_name": "BRISC and BRCA1-A complex member 1 isoform X1", "gene_name": "Babam1", "gene_names_uniprotkb": "Babam1", "gene_names_refseq": "Babam1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M8E3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M8E3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "NSPTEEEEEEEEEEEEGEEP", "down_seq": "PEPRPHTRSNPEGAEDRALG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr27", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "27", "end_pos": "27" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MFI9-1.367.367", "start_pos": 367, "end_pos": 367, "uniprot_canonical_ac": "A0A8C2MFI9-1", "length": 481, "uniprot_id": "A0A8C2MFI9_CRIGR", "protein_name": "Abl interactor 1 isoform X12", "refseq_ac": "XP_027261159", "refseq_name": "abl interactor 1 isoform X12", "gene_name": "Abi1", "gene_names_uniprotkb": "Abi1", "gene_names_refseq": "Abi1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MFI9", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MFI9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PQIPLTGFVARVQENIADSP", "down_seq": "PPPPPPPDDIPMFDDSPPPP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr367", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "367", "end_pos": "367" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M8K8-1.155.155", "start_pos": 155, "end_pos": 155, "uniprot_canonical_ac": "A0A8C2M8K8-1", "length": 937, "uniprot_id": "A0A8C2M8K8_CRIGR", "protein_name": "Inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X2", "refseq_ac": "XP_027256299", "refseq_name": "inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X2", "gene_name": "Ror1", "gene_names_uniprotkb": "Ror1", "gene_names_refseq": "Ror1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M8K8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M8K8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "NGKKVVSTTGVLFVKFGPAP", "down_seq": "ASPGSSDEYEEDGFCQPYRG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr155", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "155", "end_pos": "155" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M904-1.1894.1894", "start_pos": 1894, "end_pos": 1894, "uniprot_canonical_ac": "A0A8C2M904-1", "length": 2111, "uniprot_id": "A0A8C2M904_CRIGR", "protein_name": "Unconventional myosin-VIIb", "refseq_ac": "XP_035294950", "refseq_name": "unconventional myosin-VIIb isoform X2", "gene_name": "Myo7b", "gene_names_uniprotkb": "Myo7b", "gene_names_refseq": "Myo7b", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M904", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M904" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GAPITLPYQVFFMRKLWLNV", "down_seq": "PGKDMNADTILHYHQELPKY", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1894", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1894", "end_pos": "1894" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M990-1.82.82", "start_pos": 82, "end_pos": 82, "uniprot_canonical_ac": "A0A8C2M990-1", "length": 1165, "uniprot_id": "A0A8C2M990_CRIGR", "protein_name": "PDZ domain-containing protein 8", "refseq_ac": "XP_027262666", "refseq_name": "PDZ domain-containing protein 8 isoform X2", "gene_name": "Pdzd8", "gene_names_uniprotkb": "Pdzd8", "gene_names_refseq": "Pdzd8", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M990", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M990" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GGGSGGEEPAAGSCEAGASP", "down_seq": "PTPSATATATATPDSPAPPT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr82", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "82", "end_pos": "82" }, { "start_pos": "84", "end_pos": "84" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "upstream", "id": "A0A8C2M990-1.84.84", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M990-1.84.84", "start_pos": 84, "end_pos": 84, "uniprot_canonical_ac": "A0A8C2M990-1", "length": 1165, "uniprot_id": "A0A8C2M990_CRIGR", "protein_name": "PDZ domain-containing protein 8", "refseq_ac": "XP_027262666", "refseq_name": "PDZ domain-containing protein 8 isoform X2", "gene_name": "Pdzd8", "gene_names_uniprotkb": "Pdzd8", "gene_names_refseq": "Pdzd8", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M990", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M990" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GSGGEEPAAGSCEAGASPTP", "down_seq": "PSATATATATPDSPAPPTRE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr84", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "82", "end_pos": "82" }, { "start_pos": "84", "end_pos": "84" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "downstream", "id": "A0A8C2M990-1.82.82", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M9P5-1.191.191", "start_pos": 191, "end_pos": 191, "uniprot_canonical_ac": "A0A8C2M9P5-1", "length": 756, "uniprot_id": "A0A8C2M9P5_CRIGR", "protein_name": "Phosphoinositide phospholipase C", "refseq_ac": "XP_027271160", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X2", "gene_name": "Plcd1", "gene_names_uniprotkb": "Plcd1", "gene_names_refseq": "Plcd1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M9P5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M9P5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A8C2M9P5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M9P5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR628391-4", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR628391-4", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "ELNIQVDDSYARKIFRECDH", "down_seq": "QTDSLEDEEIETFYKMLTQR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "S", "relation": "attached", "comment": "O-linked (GlcNAc) serine;O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser191", "evidence": [ { "id": "A0A8C2M9P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M9P5#ptm_processing" }, { "id": "PIRSR628391-4", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR628391-4" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "191", "end_pos": "191" }, { "start_pos": "193", "end_pos": "193" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "upstream", "id": "A0A8C2M9P5-1.193.193", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M9P5-1.193.193", "start_pos": 193, "end_pos": 193, "uniprot_canonical_ac": "A0A8C2M9P5-1", "length": 756, "uniprot_id": "A0A8C2M9P5_CRIGR", "protein_name": "Phosphoinositide phospholipase C", "refseq_ac": "XP_027271160", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X2", "gene_name": "Plcd1", "gene_names_uniprotkb": "Plcd1", "gene_names_refseq": "Plcd1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M9P5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M9P5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A8C2M9P5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M9P5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR628391-4", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR628391-4", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "NIQVDDSYARKIFRECDHSQ", "down_seq": "DSLEDEEIETFYKMLTQRAE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "T", "relation": "attached", "comment": "O-linked (GlcNAc) threonine;O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr193", "evidence": [ { "id": "A0A8C2M9P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M9P5#ptm_processing" }, { "id": "PIRSR628391-4", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR628391-4" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "191", "end_pos": "191" }, { "start_pos": "193", "end_pos": "193" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "downstream", "id": "A0A8C2M9P5-1.191.191", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MA04-1.25.25", "start_pos": 25, "end_pos": 25, "uniprot_canonical_ac": "A0A8C2MA04-1", "length": 468, "uniprot_id": "A0A8C2MA04_CRIGR", "protein_name": "Sushi repeat-containing protein SRPX2", "refseq_ac": "XP_027288655", "refseq_name": "sushi repeat-containing protein SRPX2 isoform X2", "gene_name": "Srpx2", "gene_names_uniprotkb": "Srpx2", "gene_names_refseq": "Srpx2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MA04", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MA04" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AGQLTQRGALSLLLFLTPAV", "down_seq": "PTWYAGSGYHPDESYNEVYA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr25", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "25", "end_pos": "25" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MA78-1.224.224", "start_pos": 224, "end_pos": 224, "uniprot_canonical_ac": "A0A8C2MA78-1", "length": 315, "uniprot_id": "A0A8C2MA78_CRIGR", "protein_name": "Integrin-binding sialoprotein", "refseq_ac": "XP_027244257", "refseq_name": "bone sialoprotein 2 isoform X2", "gene_name": "Ibsp", "gene_names_uniprotkb": "Ibsp", "gene_names_refseq": "Ibsp", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MA78", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MA78" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VTEAGVEGTTLDREQISDGP", "down_seq": "TAVLPNGFQYTTPPPEAYGT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr224", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "224", "end_pos": "224" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MBC4-1.266.266", "start_pos": 266, "end_pos": 266, "uniprot_canonical_ac": "A0A8C2MBC4-1", "length": 314, "uniprot_id": "A0A8C2MBC4_CRIGR", "protein_name": "Homeobox protein", "refseq_ac": "XP_027265836", "refseq_name": "pituitary homeobox 1 isoform X2", "gene_name": "Pitx1", "gene_names_uniprotkb": "Pitx1", "gene_names_refseq": "Pitx1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MBC4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MBC4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "NNLTGSSLNSAMSPGACPYG", "down_seq": "PASPYSVYRDTCNSSLASLR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr266", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "266", "end_pos": "266" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MBN0-1.54.54", "start_pos": 54, "end_pos": 54, "uniprot_canonical_ac": "A0A8C2MBN0-1", "length": 211, "uniprot_id": "A0A8C2MBN0_CRIGR", "protein_name": "Regulator of G-protein signaling 2", "refseq_ac": "XP_003499267", "refseq_name": "regulator of G-protein signaling 2", "gene_name": "Rgs2", "gene_names_uniprotkb": "Rgs2", "gene_names_refseq": "Rgs2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MBN0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MBN0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "KRTLLKDWKTRLSYFLQNSS", "down_seq": "PGKPKTGKKSKQQTFIKPSP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr54", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "54", "end_pos": "54" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MBS7-1.316.316", "start_pos": 316, "end_pos": 316, "uniprot_canonical_ac": "A0A8C2MBS7-1", "length": 483, "uniprot_id": "A0A8C2MBS7_CRIGR", "protein_name": "Cyclic AMP-dependent transcription factor ATF-7", "refseq_ac": "XP_027252512", "refseq_name": "cyclic AMP-dependent transcription factor ATF-7 isoform X1", "gene_name": "LOC100764874", "gene_names_uniprotkb": "LOC100764874", "gene_names_refseq": "LOC100764874", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MBS7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MBS7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LIQHPDTPSPAQPQVSPAQP", "down_seq": "PSTGGRRRRTVDEDPDERRQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr316", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "316", "end_pos": "316" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MBW7-1.17.17", "start_pos": 17, "end_pos": 17, "uniprot_canonical_ac": "A0A8C2MBW7-1", "length": 84, "uniprot_id": "A0A8C2MBW7_CRIGR", "protein_name": "GTP cyclohydrolase 1 feedback regulatory protein", "refseq_ac": "XP_027277980", "refseq_name": "GTP cyclohydrolase 1 feedback regulatory protein", "gene_name": "LOC113836405", "gene_names_uniprotkb": "LOC113836405", "gene_names_refseq": "LOC113836405", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MBW7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MBW7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MPYLLISTQIRMEVGP", "down_seq": "MVGDEHSDPELMQHLGASKR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr17", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "17", "end_pos": "17" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MCA9-1.287.287", "start_pos": 287, "end_pos": 287, "uniprot_canonical_ac": "A0A8C2MCA9-1", "length": 346, "uniprot_id": "A0A8C2MCA9_CRIGR", "protein_name": "Somatostatin receptor type 2", "refseq_ac": "XP_035303315", "refseq_name": "somatostatin receptor type 2", "gene_name": "Sstr2", "gene_names_uniprotkb": "Sstr2", "gene_names_refseq": "Sstr2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MCA9", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MCA9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "FCWLPFYIFNVSSVSVAISP", "down_seq": "PALKGMFDFVVILTYANSCA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr287", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "287", "end_pos": "287" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MFY3-1.309.309", "start_pos": 309, "end_pos": 309, "uniprot_canonical_ac": "A0A8C2MFY3-1", "length": 564, "uniprot_id": "A0A8C2MFY3_CRIGR", "protein_name": "Poly(U)-binding-splicing factor PUF60", "refseq_ac": "XP_016833736", "refseq_name": "poly(U)-binding-splicing factor PUF60 isoform X1", "gene_name": "Puf60", "gene_names_uniprotkb": "Puf60", "gene_names_refseq": "Puf60", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MFY3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MFY3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VSSMNLFDLGGQYLRVGKAV", "down_seq": "PPMPLLTPATPGGLPPAAAV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr309", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "309", "end_pos": "309" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "355", "end_pos": "355" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 10, "direction": "upstream", "id": "A0A8C2MFY3-1.319.319", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MFY3-1.319.319", "start_pos": 319, "end_pos": 319, "uniprot_canonical_ac": "A0A8C2MFY3-1", "length": 564, "uniprot_id": "A0A8C2MFY3_CRIGR", "protein_name": "Poly(U)-binding-splicing factor PUF60", "refseq_ac": "XP_016833736", "refseq_name": "poly(U)-binding-splicing factor PUF60 isoform X1", "gene_name": "Puf60", "gene_names_uniprotkb": "Puf60", "gene_names_refseq": "Puf60", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MFY3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MFY3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GQYLRVGKAVTPPMPLLTPA", "down_seq": "PGGLPPAAAVAAAAATAKIT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr319", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "309", "end_pos": "309" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "355", "end_pos": "355" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 10, "direction": "downstream", "id": "A0A8C2MFY3-1.309.309", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MFY3-1.355.355", "start_pos": 355, "end_pos": 355, "uniprot_canonical_ac": "A0A8C2MFY3-1", "length": 564, "uniprot_id": "A0A8C2MFY3_CRIGR", "protein_name": "Poly(U)-binding-splicing factor PUF60", "refseq_ac": "XP_016833736", "refseq_name": "poly(U)-binding-splicing factor PUF60 isoform X1", "gene_name": "Puf60", "gene_names_uniprotkb": "Puf60", "gene_names_refseq": "Puf60", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MFY3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MFY3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TAKITAQEAVAGAAVLGTLA", "down_seq": "PGLVSPALTLAQPLGALPQA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr355", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "309", "end_pos": "309" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "355", "end_pos": "355" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MDD7-1.408.408", "start_pos": 408, "end_pos": 408, "uniprot_canonical_ac": "A0A8C2MDD7-1", "length": 585, "uniprot_id": "A0A8C2MDD7_CRIGR", "protein_name": "5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase", "refseq_ac": "XP_027285069", "refseq_name": "mRNA-decapping enzyme 1B isoform X4", "gene_name": "Dcp1b", "gene_names_uniprotkb": "Dcp1b", "gene_names_refseq": "Dcp1b", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MDD7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MDD7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PCQSVAHSQLVYFSGPLPPP", "down_seq": "PGHQTLRKEQCALPAQALSL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr408", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "408", "end_pos": "408" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MDF0-1.322.322", "start_pos": 322, "end_pos": 322, "uniprot_canonical_ac": "A0A8C2MDF0-1", "length": 428, "uniprot_id": "A0A8C2MDF0_CRIGR", "protein_name": "Homeobox protein Hox-B3 isoform X2", "refseq_ac": "XP_035303848", "refseq_name": "homeobox protein Hox-B3 isoform X2", "gene_name": "Hoxb3", "gene_names_uniprotkb": "Hoxb3", "gene_names_refseq": "Hoxb3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MDF0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MDF0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LPSNYQTPLKGCGAPQKYPP", "down_seq": "PAPEYEPHVLQANGGAYGTP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr322", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "322", "end_pos": "322" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MDF5-1.172.172", "start_pos": 172, "end_pos": 172, "uniprot_canonical_ac": "A0A8C2MDF5-1", "length": 629, "uniprot_id": "A0A8C2MDF5_CRIGR", "protein_name": "Junctophilin", "refseq_ac": "XP_035308336", "refseq_name": "junctophilin-4 isoform X2", "gene_name": "Jph4", "gene_names_uniprotkb": "Jph4", "gene_names_refseq": "Jph4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MDF5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MDF5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AALLRSPRRTSLDSGHSDPP", "down_seq": "PPPPLPLPGDEGGSPASGSR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr172", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "172", "end_pos": "172" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2ME34-1.108.108", "start_pos": 108, "end_pos": 108, "uniprot_canonical_ac": "A0A8C2ME34-1", "length": 250, "uniprot_id": "A0A8C2ME34_CRIGR", "protein_name": "Homeobox protein", "refseq_ac": "XP_027280028", "refseq_name": "homeobox protein Hox-B9", "gene_name": "LOC113836565", "gene_names_uniprotkb": "LOC113836565", "gene_names_refseq": "LOC113836565", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2ME34", "url": "https://www.uniprot.org/uniprotkb/A0A8C2ME34" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PAAESRYLRTWLEPAPRAEA", "down_seq": "PGQGQAAVKAEPLLGAPGEL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr108", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "108", "end_pos": "108" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MED2-1.422.422", "start_pos": 422, "end_pos": 422, "uniprot_canonical_ac": "A0A8C2MED2-1", "length": 445, "uniprot_id": "A0A8C2MED2_CRIGR", "protein_name": "FAS-associated factor 2", "refseq_ac": "XP_027265659", "refseq_name": "FAS-associated factor 2 isoform X2", "gene_name": "Faf2", "gene_names_uniprotkb": "Faf2", "gene_names_refseq": "Faf2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MED2", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MED2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QIEANFPRRVLPCVPSEEWP", "down_seq": "PPTLQEAGLSHTEVLFVQDL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr422", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "422", "end_pos": "422" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MEK4-1.278.278", "start_pos": 278, "end_pos": 278, "uniprot_canonical_ac": "A0A8C2MEK4-1", "length": 1072, "uniprot_id": "A0A8C2MEK4_CRIGR", "protein_name": "LOW QUALITY PROTEIN: la-related protein 1 isoform X2", "refseq_ac": "XP_027283232", "refseq_name": "LOW QUALITY PROTEIN: la-related protein 1 isoform X2", "gene_name": "Larp1", "gene_names_uniprotkb": "Larp1", "gene_names_refseq": "Larp1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MEK4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MEK4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RGEIKGSEPVTYMPVSVAPP", "down_seq": "PAWQPETKPEPAWHDQDETS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr278", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "278", "end_pos": "278" }, { "start_pos": "503", "end_pos": "503" }, { "start_pos": "833", "end_pos": "833" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MEK4-1.503.503", "start_pos": 503, "end_pos": 503, "uniprot_canonical_ac": "A0A8C2MEK4-1", "length": 1072, "uniprot_id": "A0A8C2MEK4_CRIGR", "protein_name": "LOW QUALITY PROTEIN: la-related protein 1 isoform X2", "refseq_ac": "XP_027283232", "refseq_name": "LOW QUALITY PROTEIN: la-related protein 1 isoform X2", "gene_name": "Larp1", "gene_names_uniprotkb": "Larp1", "gene_names_refseq": "Larp1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MEK4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MEK4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VPRQHYQKETESAPGSPRAV", "down_seq": "PVPTKTEEVSNLKTLPKGLS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr503", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "278", "end_pos": "278" }, { "start_pos": "503", "end_pos": "503" }, { "start_pos": "833", "end_pos": "833" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MEK4-1.833.833", "start_pos": 833, "end_pos": 833, "uniprot_canonical_ac": "A0A8C2MEK4-1", "length": 1072, "uniprot_id": "A0A8C2MEK4_CRIGR", "protein_name": "LOW QUALITY PROTEIN: la-related protein 1 isoform X2", "refseq_ac": "XP_027283232", "refseq_name": "LOW QUALITY PROTEIN: la-related protein 1 isoform X2", "gene_name": "Larp1", "gene_names_uniprotkb": "Larp1", "gene_names_refseq": "Larp1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MEK4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MEK4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MDSREHRPRTASISSSPSEG", "down_seq": "PAVGSYGCTPQSLPKFQHPS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr833", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "278", "end_pos": "278" }, { "start_pos": "503", "end_pos": "503" }, { "start_pos": "833", "end_pos": "833" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MF21-1.43.43", "start_pos": 43, "end_pos": 43, "uniprot_canonical_ac": "A0A8C2MF21-1", "length": 461, "uniprot_id": "A0A8C2MF21_CRIGR", "protein_name": "N-myc proto-oncogene protein isoform X2", "refseq_ac": "XP_027280446", "refseq_name": "N-myc proto-oncogene protein isoform X2", "gene_name": "Mycn", "gene_names_uniprotkb": "Mycn", "gene_names_refseq": "Mycn", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MF21", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MF21" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SLQPCFYPDEDDFYFGGPDS", "down_seq": "PPGEDIWKKFELLPTPPLSP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr43", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "43", "end_pos": "43" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MHA4-1.629.629", "start_pos": 629, "end_pos": 629, "uniprot_canonical_ac": "A0A8C2MHA4-1", "length": 651, "uniprot_id": "A0A8C2MHA4_CRIGR", "protein_name": "Forkhead box protein N1 isoform X3", "refseq_ac": "XP_027281934", "refseq_name": "forkhead box protein N1 isoform X3", "gene_name": "LOC100762193", "gene_names_uniprotkb": "LOC100762193", "gene_names_refseq": "LOC100762193", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MHA4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MHA4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GALGDLHLSTLYSAFVELEP", "down_seq": "PSSAAAGPAVYLSPGSKPMA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr629", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "629", "end_pos": "629" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MHJ3-1.548.548", "start_pos": 548, "end_pos": 548, "uniprot_canonical_ac": "A0A8C2MHJ3-1", "length": 557, "uniprot_id": "A0A8C2MHJ3_CRIGR", "protein_name": "Copine-6", "refseq_ac": "XP_035308792", "refseq_name": "copine-6 isoform X2", "gene_name": "Cpne6", "gene_names_uniprotkb": "Cpne6", "gene_names_refseq": "Cpne6", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MHJ3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MHJ3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RQVVEYYASQGISPGAPRPS", "down_seq": "PAVTPSPSP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr548", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "548", "end_pos": "548" }, { "start_pos": "552", "end_pos": "552" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "upstream", "id": "A0A8C2MHJ3-1.552.552", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MHJ3-1.552.552", "start_pos": 552, "end_pos": 552, "uniprot_canonical_ac": "A0A8C2MHJ3-1", "length": 557, "uniprot_id": "A0A8C2MHJ3_CRIGR", "protein_name": "Copine-6", "refseq_ac": "XP_035308792", "refseq_name": "copine-6 isoform X2", "gene_name": "Cpne6", "gene_names_uniprotkb": "Cpne6", "gene_names_refseq": "Cpne6", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MHJ3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MHJ3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EYYASQGISPGAPRPSTPAV", "down_seq": "PSPSP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr552", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "548", "end_pos": "548" }, { "start_pos": "552", "end_pos": "552" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "downstream", "id": "A0A8C2MHJ3-1.548.548", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MHP7-1.219.219", "start_pos": 219, "end_pos": 219, "uniprot_canonical_ac": "A0A8C2MHP7-1", "length": 421, "uniprot_id": "A0A8C2MHP7_CRIGR", "protein_name": "Runt-related transcription factor", "refseq_ac": "XP_027255468", "refseq_name": "runt-related transcription factor 3 isoform X2", "gene_name": "Runx3", "gene_names_uniprotkb": "Runx3", "gene_names_refseq": "Runx3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MHP7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MHP7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "KIEDQTKAFPDRFGDLRMRV", "down_seq": "PSTPSPRGSLSTTSHFSSQA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr219", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "219", "end_pos": "219" }, { "start_pos": "222", "end_pos": "222" }, { "start_pos": "293", "end_pos": "293" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 3, "direction": "upstream", "id": "A0A8C2MHP7-1.222.222", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MHP7-1.222.222", "start_pos": 222, "end_pos": 222, "uniprot_canonical_ac": "A0A8C2MHP7-1", "length": 421, "uniprot_id": "A0A8C2MHP7_CRIGR", "protein_name": "Runt-related transcription factor", "refseq_ac": "XP_027255468", "refseq_name": "runt-related transcription factor 3 isoform X2", "gene_name": "Runx3", "gene_names_uniprotkb": "Runx3", "gene_names_refseq": "Runx3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MHP7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MHP7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DQTKAFPDRFGDLRMRVTPS", "down_seq": "PSPRGSLSTTSHFSSQAQTP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr222", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "219", "end_pos": "219" }, { "start_pos": "222", "end_pos": "222" }, { "start_pos": "293", "end_pos": "293" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 3, "direction": "downstream", "id": "A0A8C2MHP7-1.219.219", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MHP7-1.293.293", "start_pos": 293, "end_pos": 293, "uniprot_canonical_ac": "A0A8C2MHP7-1", "length": 421, "uniprot_id": "A0A8C2MHP7_CRIGR", "protein_name": "Runt-related transcription factor", "refseq_ac": "XP_027255468", "refseq_name": "runt-related transcription factor 3 isoform X2", "gene_name": "Runx3", "gene_names_uniprotkb": "Runx3", "gene_names_refseq": "Runx3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MHP7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MHP7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "FPDPRMHYPGAMSAAFPYSA", "down_seq": "PSGTSLGSLSVAGMPASSRF", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr293", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "219", "end_pos": "219" }, { "start_pos": "222", "end_pos": "222" }, { "start_pos": "293", "end_pos": "293" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MHT4-1.295.295", "start_pos": 295, "end_pos": 295, "uniprot_canonical_ac": "A0A8C2MHT4-1", "length": 627, "uniprot_id": "A0A8C2MHT4_CRIGR", "protein_name": "E3 ubiquitin-protein ligase", "refseq_ac": "XP_035300530", "refseq_name": "E3 ubiquitin-protein ligase DTX1 isoform X2", "gene_name": "Dtx1", "gene_names_uniprotkb": "Dtx1", "gene_names_refseq": "Dtx1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MHT4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MHT4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EPAPPPGVPPRSPSAPNGAP", "down_seq": "PGQNNLSRPGPQRATSVSAR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr295", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "295", "end_pos": "295" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MI09-1.8.8", "start_pos": 8, "end_pos": 8, "uniprot_canonical_ac": "A0A8C2MI09-1", "length": 447, "uniprot_id": "A0A8C2MI09_CRIGR", "protein_name": "Acyl-CoA (8-3)-desaturase", "refseq_ac": "XP_027262533", "refseq_name": "acyl-CoA (8-3)-desaturase isoform X3", "gene_name": "LOC100773095", "gene_names_uniprotkb": "LOC100773095", "gene_names_refseq": "LOC100773095", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MI09", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MI09" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MAPDPVP", "down_seq": "PVPGSAQLHQPRYFTWEEVA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr8", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "8", "end_pos": "8" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MJ01-1.194.194", "start_pos": 194, "end_pos": 194, "uniprot_canonical_ac": "A0A8C2MJ01-1", "length": 415, "uniprot_id": "A0A8C2MJ01_CRIGR", "protein_name": "Ena/VASP-like protein", "refseq_ac": "XP_027272178", "refseq_name": "ena/VASP-like protein isoform X3", "gene_name": "Evl", "gene_names_uniprotkb": "Evl", "gene_names_refseq": "Evl", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MJ01", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MJ01" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ATLSCSGPPPPPPPPVPPPP", "down_seq": "GATPPPPPPLPAGGAQGANH", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr194", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "194", "end_pos": "194" }, { "start_pos": "197", "end_pos": "197" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 3, "direction": "upstream", "id": "A0A8C2MJ01-1.197.197", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MJ01-1.197.197", "start_pos": 197, "end_pos": 197, "uniprot_canonical_ac": "A0A8C2MJ01-1", "length": 415, "uniprot_id": "A0A8C2MJ01_CRIGR", "protein_name": "Ena/VASP-like protein", "refseq_ac": "XP_027272178", "refseq_name": "ena/VASP-like protein isoform X3", "gene_name": "Evl", "gene_names_uniprotkb": "Evl", "gene_names_refseq": "Evl", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MJ01", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MJ01" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SCSGPPPPPPPPVPPPPTGA", "down_seq": "PPPPPPLPAGGAQGANHDES", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr197", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "194", "end_pos": "194" }, { "start_pos": "197", "end_pos": "197" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 3, "direction": "downstream", "id": "A0A8C2MJ01-1.194.194", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MJ89-1.83.83", "start_pos": 83, "end_pos": 83, "uniprot_canonical_ac": "A0A8C2MJ89-1", "length": 595, "uniprot_id": "A0A8C2MJ89_CRIGR", "protein_name": "Putative histone-lysine N-methyltransferase PRDM6", "refseq_ac": "XP_035294927", "refseq_name": "putative histone-lysine N-methyltransferase PRDM6 isoform X2", "gene_name": "Prdm6", "gene_names_uniprotkb": "Prdm6", "gene_names_refseq": "Prdm6", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MJ89", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MJ89" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AEPSPDGLRPRPASISSVSS", "down_seq": "PAPSSTSASSASSCAAAAAA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr83", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "83", "end_pos": "83" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MJB3-1.482.482", "start_pos": 482, "end_pos": 482, "uniprot_canonical_ac": "A0A8C2MJB3-1", "length": 1007, "uniprot_id": "A0A8C2MJB3_CRIGR", "protein_name": "Ephrin type-A receptor 10", "refseq_ac": "XP_035294807", "refseq_name": "ephrin type-A receptor 10 isoform X2", "gene_name": "Epha10", "gene_names_uniprotkb": "Epha10", "gene_names_refseq": "Epha10", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MJB3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MJB3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RDRVEPQSVSLSWREPVPAG", "down_seq": "PGANGTEYEIRYYEKGQSEQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr482", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "482", "end_pos": "482" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MJV4-1.405.405", "start_pos": 405, "end_pos": 405, "uniprot_canonical_ac": "A0A8C2MJV4-1", "length": 731, "uniprot_id": "A0A8C2MJV4_CRIGR", "protein_name": "ADP-ribosylation factor-binding protein GGA3 isoform X2", "refseq_ac": "XP_007641214", "refseq_name": "ADP-ribosylation factor-binding protein GGA3 isoform X1", "gene_name": "Gga3", "gene_names_uniprotkb": "Gga3", "gene_names_refseq": "Gga3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MJV4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MJV4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SGLSLLDEELLCLGLTDPAP", "down_seq": "ASKESAGNSQWHLFQSEPSS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr405", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "405", "end_pos": "405" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MKH4-1.226.226", "start_pos": 226, "end_pos": 226, "uniprot_canonical_ac": "A0A8C2MKH4-1", "length": 379, "uniprot_id": "A0A8C2MKH4_CRIGR", "protein_name": "Wnt inhibitory factor 1", "refseq_ac": "XP_003497172", "refseq_name": "wnt inhibitory factor 1", "gene_name": "Wif1", "gene_names_uniprotkb": "Wif1", "gene_names_refseq": "Wif1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MKH4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MKH4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GPHCEKALCIPRCMNGGLCV", "down_seq": "PGFCICPPGFYGVNCDKANC", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr226", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "226", "end_pos": "226" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MKJ5-1.218.218", "start_pos": 218, "end_pos": 218, "uniprot_canonical_ac": "A0A8C2MKJ5-1", "length": 2114, "uniprot_id": "A0A8C2MKJ5_CRIGR", "protein_name": "Dysferlin", "refseq_ac": "XP_027284343", "refseq_name": "dysferlin isoform X2", "gene_name": "Dysf", "gene_names_uniprotkb": "Dysf", "gene_names_refseq": "Dysf", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MKJ5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MKJ5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TGDEAEPFLDQSGAVGPGGP", "down_seq": "TPKKLPSHPPPHHPGAKRKR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr218", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "218", "end_pos": "218" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MKN0-1.215.215", "start_pos": 215, "end_pos": 215, "uniprot_canonical_ac": "A0A8C2MKN0-1", "length": 375, "uniprot_id": "A0A8C2MKN0_CRIGR", "protein_name": "RNA binding protein fox-1 homolog 3", "refseq_ac": "XP_035303633", "refseq_name": "RNA binding protein fox-1 homolog 3 isoform X1", "gene_name": "Rbfox3", "gene_names_uniprotkb": "Rbfox3", "gene_names_refseq": "Rbfox3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MKN0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MKN0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PVVGAVYGPEFYAVTSFPYP", "down_seq": "TGTTVAYRGAHLRGRGRAVY", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr215", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "215", "end_pos": "215" }, { "start_pos": "353", "end_pos": "353" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MKN0-1.353.353", "start_pos": 353, "end_pos": 353, "uniprot_canonical_ac": "A0A8C2MKN0-1", "length": 375, "uniprot_id": "A0A8C2MKN0_CRIGR", "protein_name": "RNA binding protein fox-1 homolog 3", "refseq_ac": "XP_035303633", "refseq_name": "RNA binding protein fox-1 homolog 3 isoform X1", "gene_name": "Rbfox3", "gene_names_uniprotkb": "Rbfox3", "gene_names_refseq": "Rbfox3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MKN0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MKN0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SDSYGRVYAATDPYHHTIGP", "down_seq": "ATYSIGTMASLCRGGYSRFT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr353", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "215", "end_pos": "215" }, { "start_pos": "353", "end_pos": "353" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2ML72-1.101.101", "start_pos": 101, "end_pos": 101, "uniprot_canonical_ac": "A0A8C2ML72-1", "length": 597, "uniprot_id": "A0A8C2ML72_CRIGR", "protein_name": "Ubiquilin-4", "refseq_ac": "XP_027248937", "refseq_name": "ubiquilin-4 isoform X2", "gene_name": "Ubqln4", "gene_names_uniprotkb": "Ubqln4", "gene_names_refseq": "Ubqln4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2ML72", "url": "https://www.uniprot.org/uniprotkb/A0A8C2ML72" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VIKTPQKAQDPVAAAGSPPS", "down_seq": "PDSASAPSTTPASPAAPAQA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr101", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "101", "end_pos": "101" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "357", "end_pos": "357" }, { "start_pos": "511", "end_pos": "511" }, { "start_pos": "523", "end_pos": "523" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2ML72-1.140.140", "start_pos": 140, "end_pos": 140, "uniprot_canonical_ac": "A0A8C2ML72-1", "length": 597, "uniprot_id": "A0A8C2ML72_CRIGR", "protein_name": "Ubiquilin-4", "refseq_ac": "XP_027248937", "refseq_name": "ubiquilin-4 isoform X2", "gene_name": "Ubqln4", "gene_names_uniprotkb": "Ubqln4", "gene_names_refseq": "Ubqln4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2ML72", "url": "https://www.uniprot.org/uniprotkb/A0A8C2ML72" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QACGSGSATSDAAAAGARGP", "down_seq": "PVAAEGPPSATASILSGFGG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr140", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "101", "end_pos": "101" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "357", "end_pos": "357" }, { "start_pos": "511", "end_pos": "511" }, { "start_pos": "523", "end_pos": "523" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2ML72-1.357.357", "start_pos": 357, "end_pos": 357, "uniprot_canonical_ac": "A0A8C2ML72-1", "length": 597, "uniprot_id": "A0A8C2ML72_CRIGR", "protein_name": "Ubiquilin-4", "refseq_ac": "XP_027248937", "refseq_name": "ubiquilin-4 isoform X2", "gene_name": "Ubqln4", "gene_names_uniprotkb": "Ubqln4", "gene_names_refseq": "Ubqln4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2ML72", "url": "https://www.uniprot.org/uniprotkb/A0A8C2ML72" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QAPGSGGEGNGGSGTSQVHP", "down_seq": "VSNPFGINAASLGSGMFNSP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr357", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "101", "end_pos": "101" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "357", "end_pos": "357" }, { "start_pos": "511", "end_pos": "511" }, { "start_pos": "523", "end_pos": "523" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2ML72-1.511.511", "start_pos": 511, "end_pos": 511, "uniprot_canonical_ac": "A0A8C2ML72-1", "length": 597, "uniprot_id": "A0A8C2ML72_CRIGR", "protein_name": "Ubiquilin-4", "refseq_ac": "XP_027248937", "refseq_name": "ubiquilin-4 isoform X2", "gene_name": "Ubqln4", "gene_names_uniprotkb": "Ubqln4", "gene_names_refseq": "Ubqln4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2ML72", "url": "https://www.uniprot.org/uniprotkb/A0A8C2ML72" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TSRTPVPLAGSNSGSAAEAP", "down_seq": "SSPGVPATSPPTPGSSAQQQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr511", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "101", "end_pos": "101" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "357", "end_pos": "357" }, { "start_pos": "511", "end_pos": "511" }, { "start_pos": "523", "end_pos": "523" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 12, "direction": "upstream", "id": "A0A8C2ML72-1.523.523", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2ML72-1.523.523", "start_pos": 523, "end_pos": 523, "uniprot_canonical_ac": "A0A8C2ML72-1", "length": 597, "uniprot_id": "A0A8C2ML72_CRIGR", "protein_name": "Ubiquilin-4", "refseq_ac": "XP_027248937", "refseq_name": "ubiquilin-4 isoform X2", "gene_name": "Ubqln4", "gene_names_uniprotkb": "Ubqln4", "gene_names_refseq": "Ubqln4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2ML72", "url": "https://www.uniprot.org/uniprotkb/A0A8C2ML72" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SGSAAEAPTSSPGVPATSPP", "down_seq": "PGSSAQQQLMQQMIQLLAGG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr523", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "101", "end_pos": "101" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "357", "end_pos": "357" }, { "start_pos": "511", "end_pos": "511" }, { "start_pos": "523", "end_pos": "523" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 12, "direction": "downstream", "id": "A0A8C2ML72-1.511.511", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MLL1-1.6.6", "start_pos": 6, "end_pos": 6, "uniprot_canonical_ac": "A0A8C2MLL1-1", "length": 297, "uniprot_id": "A0A8C2MLL1_CRIGR", "protein_name": "Myozenin-1", "refseq_ac": "XP_035292943", "refseq_name": "myozenin-1", "gene_name": "Myoz1", "gene_names_uniprotkb": "Myoz1", "gene_names_refseq": "Myoz1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MLL1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MLL1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MPLSG", "down_seq": "PAPNKRRKPSKLIMELTGGG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr6", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "6", "end_pos": "6" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MLM4-1.399.399", "start_pos": 399, "end_pos": 399, "uniprot_canonical_ac": "A0A8C2MLM4-1", "length": 858, "uniprot_id": "A0A8C2MLM4_CRIGR", "protein_name": "Carbohydrate-responsive element-binding protein", "refseq_ac": "XP_016830375", "refseq_name": "carbohydrate-responsive element-binding protein", "gene_name": "Mlxipl", "gene_names_uniprotkb": "Mlxipl", "gene_names_refseq": "Mlxipl", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MLM4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MLM4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EDPKTKIPPAPVPTPLLPYP", "down_seq": "PDKAQGLEPCTPTPFPTMAP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr399", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "399", "end_pos": "399" }, { "start_pos": "580", "end_pos": "580" }, { "start_pos": "582", "end_pos": "582" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MLM4-1.580.580", "start_pos": 580, "end_pos": 580, "uniprot_canonical_ac": "A0A8C2MLM4-1", "length": 858, "uniprot_id": "A0A8C2MLM4_CRIGR", "protein_name": "Carbohydrate-responsive element-binding protein", "refseq_ac": "XP_016830375", "refseq_name": "carbohydrate-responsive element-binding protein", "gene_name": "Mlxipl", "gene_names_uniprotkb": "Mlxipl", "gene_names_refseq": "Mlxipl", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MLM4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MLM4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SPQDTVSELLRARAFFPPIP", "down_seq": "PTPPQPPPGPATLAPPRSLI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr580", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "399", "end_pos": "399" }, { "start_pos": "580", "end_pos": "580" }, { "start_pos": "582", "end_pos": "582" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "upstream", "id": "A0A8C2MLM4-1.582.582", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MLM4-1.582.582", "start_pos": 582, "end_pos": 582, "uniprot_canonical_ac": "A0A8C2MLM4-1", "length": 858, "uniprot_id": "A0A8C2MLM4_CRIGR", "protein_name": "Carbohydrate-responsive element-binding protein", "refseq_ac": "XP_016830375", "refseq_name": "carbohydrate-responsive element-binding protein", "gene_name": "Mlxipl", "gene_names_uniprotkb": "Mlxipl", "gene_names_refseq": "Mlxipl", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MLM4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MLM4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QDTVSELLRARAFFPPIPTP", "down_seq": "PPQPPPGPATLAPPRSLIVP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr582", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "399", "end_pos": "399" }, { "start_pos": "580", "end_pos": "580" }, { "start_pos": "582", "end_pos": "582" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "downstream", "id": "A0A8C2MLM4-1.580.580", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MLZ1-1.1269.1269", "start_pos": 1269, "end_pos": 1269, "uniprot_canonical_ac": "A0A8C2MLZ1-1", "length": 1447, "uniprot_id": "A0A8C2MLZ1_CRIGR", "protein_name": "Netrin receptor DCC", "refseq_ac": "XP_035295958", "refseq_name": "netrin receptor DCC isoform X2", "gene_name": "Dcc", "gene_names_uniprotkb": "Dcc", "gene_names_refseq": "Dcc", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MLZ1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MLZ1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SAIPVPTLESAQYPGILPSP", "down_seq": "CGYPHPQFTLRPVPFPTLSV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1269", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1269", "end_pos": "1269" }, { "start_pos": "1306", "end_pos": "1306" }, { "start_pos": "1373", "end_pos": "1373" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MLZ1-1.1306.1306", "start_pos": 1306, "end_pos": 1306, "uniprot_canonical_ac": "A0A8C2MLZ1-1", "length": 1447, "uniprot_id": "A0A8C2MLZ1_CRIGR", "protein_name": "Netrin receptor DCC", "refseq_ac": "XP_035295958", "refseq_name": "netrin receptor DCC isoform X2", "gene_name": "Dcc", "gene_names_uniprotkb": "Dcc", "gene_names_refseq": "Dcc", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MLZ1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MLZ1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TLSVDRGFGAGRSQSVSEGP", "down_seq": "TQQQPMLPPAQPEHPSSEEA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1306", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1269", "end_pos": "1269" }, { "start_pos": "1306", "end_pos": "1306" }, { "start_pos": "1373", "end_pos": "1373" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MLZ1-1.1373.1373", "start_pos": 1373, "end_pos": 1373, "uniprot_canonical_ac": "A0A8C2MLZ1-1", "length": 1447, "uniprot_id": "A0A8C2MLZ1_CRIGR", "protein_name": "Netrin receptor DCC", "refseq_ac": "XP_035295958", "refseq_name": "netrin receptor DCC isoform X2", "gene_name": "Dcc", "gene_names_uniprotkb": "Dcc", "gene_names_refseq": "Dcc", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MLZ1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MLZ1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PMSAIEPKVPYTPLLSQPGP", "down_seq": "LPKTHVKTASLGLAGKARSP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1373", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1269", "end_pos": "1269" }, { "start_pos": "1306", "end_pos": "1306" }, { "start_pos": "1373", "end_pos": "1373" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MLZ6-1.206.206", "start_pos": 206, "end_pos": 206, "uniprot_canonical_ac": "A0A8C2MLZ6-1", "length": 454, "uniprot_id": "A0A8C2MLZ6_CRIGR", "protein_name": "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "refseq_ac": "XP_007641571", "refseq_name": "dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X1", "gene_name": "Dlst", "gene_names_uniprotkb": "Dlst", "gene_names_refseq": "Dlst", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MLZ6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MLZ6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PPVPSPSQLPSSKPVSAIKP", "down_seq": "AAPPLAEPGAAKGVRSEHRE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr206", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "206", "end_pos": "206" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MM22-1.254.254", "start_pos": 254, "end_pos": 254, "uniprot_canonical_ac": "A0A8C2MM22-1", "length": 491, "uniprot_id": "A0A8C2MM22_CRIGR", "protein_name": "CUGBP Elav-like family member 3", "refseq_ac": "XP_035293443", "refseq_name": "CUGBP Elav-like family member 3 isoform X1", "gene_name": "Celf3", "gene_names_uniprotkb": "Celf3", "gene_names_refseq": "Celf3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MM22", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MM22" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AVQMQHMAAINANGLIATPI", "down_seq": "PSSGTSTPPAIAATPVSAIP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr254", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "254", "end_pos": "254" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MM31-1.275.275", "start_pos": 275, "end_pos": 275, "uniprot_canonical_ac": "A0A8C2MM31-1", "length": 279, "uniprot_id": "A0A8C2MM31_CRIGR", "protein_name": "Dehydrogenase/reductase SDR family member 4", "refseq_ac": "XP_027246378", "refseq_name": "dehydrogenase/reductase SDR family member 4 isoform X2", "gene_name": "LOC100771290", "gene_names_uniprotkb": "LOC100771290", "gene_names_refseq": "LOC100771290", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MM31", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MM31" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "FLCSEDASYISGETVVVGGG", "down_seq": "PSRL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr275", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "275", "end_pos": "275" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MMA3-1.227.227", "start_pos": 227, "end_pos": 227, "uniprot_canonical_ac": "A0A8C2MMA3-1", "length": 470, "uniprot_id": "A0A8C2MMA3_CRIGR", "protein_name": "Protein C-ets-2", "refseq_ac": "XP_003508776", "refseq_name": "protein C-ets-2", "gene_name": "Ets2", "gene_names_uniprotkb": "Ets2", "gene_names_refseq": "Ets2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MMA3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MMA3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "IQAPSYPKDSLLDSMCPPSA", "down_seq": "PAGLGSEQEFQMLPKSRLNT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr227", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "227", "end_pos": "227" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MML4-1.409.409", "start_pos": 409, "end_pos": 409, "uniprot_canonical_ac": "A0A8C2MML4-1", "length": 558, "uniprot_id": "A0A8C2MML4_CRIGR", "protein_name": "Glutamate dehydrogenase 1, mitochondrial", "refseq_ac": "XP_027245258", "refseq_name": "glutamate dehydrogenase 1, mitochondrial isoform X2", "gene_name": "Glud1", "gene_names_uniprotkb": "Glud1", "gene_names_refseq": "Glud1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MML4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MML4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TKSNAPKVKAKIIAEGANGP", "down_seq": "TPEADKIFLERNIMVIPDLY", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr409", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "409", "end_pos": "409" }, { "start_pos": "490", "end_pos": "490" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MML4-1.490.490", "start_pos": 490, "end_pos": 490, "uniprot_canonical_ac": "A0A8C2MML4-1", "length": 558, "uniprot_id": "A0A8C2MML4_CRIGR", "protein_name": "Glutamate dehydrogenase 1, mitochondrial", "refseq_ac": "XP_027245258", "refseq_name": "glutamate dehydrogenase 1, mitochondrial isoform X2", "gene_name": "Glud1", "gene_names_uniprotkb": "Glud1", "gene_names_refseq": "Glud1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MML4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MML4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VQESLERKFGKHGGTIPVVP", "down_seq": "AEFQDRISGASEKDIVHSGL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr490", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "409", "end_pos": "409" }, { "start_pos": "490", "end_pos": "490" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MMQ5-1.269.269", "start_pos": 269, "end_pos": 269, "uniprot_canonical_ac": "A0A8C2MMQ5-1", "length": 304, "uniprot_id": "A0A8C2MMQ5_CRIGR", "protein_name": "Non-homologous end-joining factor 1", "refseq_ac": "XP_003507647", "refseq_name": "non-homologous end-joining factor 1", "gene_name": "Nhej1", "gene_names_uniprotkb": "Nhej1", "gene_names_refseq": "Nhej1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MMQ5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MMQ5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TSPRGTDSQLLDQPEQPVSS", "down_seq": "PALSEPEHEPMGASGPMQRP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr269", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "269", "end_pos": "269" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MMZ5-1.425.425", "start_pos": 425, "end_pos": 425, "uniprot_canonical_ac": "A0A8C2MMZ5-1", "length": 662, "uniprot_id": "A0A8C2MMZ5_CRIGR", "protein_name": "non-specific serine/threonine protein kinase", "refseq_ac": "XP_016834605", "refseq_name": "NUAK family SNF1-like kinase 1 isoform X1", "gene_name": "Nuak1", "gene_names_uniprotkb": "Nuak1", "gene_names_refseq": "Nuak1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MMZ5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MMZ5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RSNSEHRSHSTGFIEGIVGP", "down_seq": "VPSPFKMEQDLCRTGIPLPS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr425", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "425", "end_pos": "425" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MNF4-1.1390.1390", "start_pos": 1390, "end_pos": 1390, "uniprot_canonical_ac": "A0A8C2MNF4-1", "length": 2090, "uniprot_id": "A0A8C2MNF4_CRIGR", "protein_name": "Host cell factor 1", "refseq_ac": "XP_027288281", "refseq_name": "host cell factor 1 isoform X2", "gene_name": "Hcfc1", "gene_names_uniprotkb": "Hcfc1", "gene_names_refseq": "Hcfc1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MNF4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MNF4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QTTSTGTTMSVSVGALLPDA", "down_seq": "PSHGTLESGLEVVAVSTVTS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1390", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1390", "end_pos": "1390" }, { "start_pos": "1630", "end_pos": "1630" }, { "start_pos": "583", "end_pos": "583" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MNF4-1.1630.1630", "start_pos": 1630, "end_pos": 1630, "uniprot_canonical_ac": "A0A8C2MNF4-1", "length": 2090, "uniprot_id": "A0A8C2MNF4_CRIGR", "protein_name": "Host cell factor 1", "refseq_ac": "XP_027288281", "refseq_name": "host cell factor 1 isoform X2", "gene_name": "Hcfc1", "gene_names_uniprotkb": "Hcfc1", "gene_names_refseq": "Hcfc1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MNF4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MNF4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GQEPASSAVVATVVVQPPPP", "down_seq": "QSEVDQLSLPQELMAEAQAG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1630", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1390", "end_pos": "1390" }, { "start_pos": "1630", "end_pos": "1630" }, { "start_pos": "583", "end_pos": "583" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MNF4-1.583.583", "start_pos": 583, "end_pos": 583, "uniprot_canonical_ac": "A0A8C2MNF4-1", "length": 2090, "uniprot_id": "A0A8C2MNF4_CRIGR", "protein_name": "Host cell factor 1", "refseq_ac": "XP_027288281", "refseq_name": "host cell factor 1 isoform X2", "gene_name": "Hcfc1", "gene_names_uniprotkb": "Hcfc1", "gene_names_refseq": "Hcfc1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MNF4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MNF4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SAPTVLSVPAGTTIVKTVAV", "down_seq": "PGTTTLPATVKVASSPVMVS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr583", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1390", "end_pos": "1390" }, { "start_pos": "1630", "end_pos": "1630" }, { "start_pos": "583", "end_pos": "583" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MNG8-1.102.102", "start_pos": 102, "end_pos": 102, "uniprot_canonical_ac": "A0A8C2MNG8-1", "length": 431, "uniprot_id": "A0A8C2MNG8_CRIGR", "protein_name": "Calcium uptake protein 2, mitochondrial", "refseq_ac": "XP_007639348", "refseq_name": "calcium uptake protein 2, mitochondrial isoform X1", "gene_name": "Micu2", "gene_names_uniprotkb": "Micu2", "gene_names_refseq": "Micu2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MNG8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MNG8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LRKQRFMQFSSLEHEGEYYM", "down_seq": "PRDFLFSVMFEQVERKTLVK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr102", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "102", "end_pos": "102" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MNR9-1.523.523", "start_pos": 523, "end_pos": 523, "uniprot_canonical_ac": "A0A8C2MNR9-1", "length": 689, "uniprot_id": "A0A8C2MNR9_CRIGR", "protein_name": "Sulfhydryl oxidase", "refseq_ac": "XP_027278732", "refseq_name": "sulfhydryl oxidase 2 isoform X2", "gene_name": "Qsox2", "gene_names_uniprotkb": "Qsox2", "gene_names_refseq": "Qsox2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MNR9", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MNR9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "NSRLAGHLSEDPKFPKVPWP", "down_seq": "PDLCPACHEEIKGLDSWNED", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr523", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "523", "end_pos": "523" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MNY9-1.479.479", "start_pos": 479, "end_pos": 479, "uniprot_canonical_ac": "A0A8C2MNY9-1", "length": 1099, "uniprot_id": "A0A8C2MNY9_CRIGR", "protein_name": "Lysine-specific demethylase PHF2", "refseq_ac": "XP_027265777", "refseq_name": "lysine-specific demethylase PHF2 isoform X2", "gene_name": "Phf2", "gene_names_uniprotkb": "Phf2", "gene_names_refseq": "Phf2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MNY9", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MNY9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SDEVCDGDREKEEPPSPIEA", "down_seq": "PPRSLLEKVSKKKTPKTVKM", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr479", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "479", "end_pos": "479" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MPA3-1.14.14", "start_pos": 14, "end_pos": 14, "uniprot_canonical_ac": "A0A8C2MPA3-1", "length": 853, "uniprot_id": "A0A8C2MPA3_CRIGR", "protein_name": "KN motif and ankyrin repeat domain-containing protein 2", "refseq_ac": "XP_007638651", "refseq_name": "KN motif and ankyrin repeat domain-containing protein 2", "gene_name": "Kank2", "gene_names_uniprotkb": "Kank2", "gene_names_refseq": "Kank2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MPA3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MPA3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MAQVLHVPAPFPG", "down_seq": "PGQASPATFPSKEPEPPYSV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr14", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "14", "end_pos": "14" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MPF5-1.445.445", "start_pos": 445, "end_pos": 445, "uniprot_canonical_ac": "A0A8C2MPF5-1", "length": 656, "uniprot_id": "A0A8C2MPF5_CRIGR", "protein_name": "Matrix metalloproteinase-15 isoform X2", "refseq_ac": "XP_027261504", "refseq_name": "matrix metalloproteinase-15 isoform X2", "gene_name": "Mmp15", "gene_names_uniprotkb": "Mmp15", "gene_names_refseq": "Mmp15", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MPF5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MPF5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A8C2MPF5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MPF5", "database": "UniProtKB", "categories": [ "Protein" ] } ], "site_seq": "Y", "start_aa": "Y", "up_seq": "FVFFKGNRYWLFREANLEPG", "down_seq": "PQPLTSYGTDIPYDRIDTAI", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine; by PKDCC", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MPF5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MPF5" } ], "site_lbl": "Tyr445" } ], "all_sites": [ { "type": "phosphorylation", "site_list": [ { "start_pos": "445", "end_pos": "445" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MPQ3-1.697.697", "start_pos": 697, "end_pos": 697, "uniprot_canonical_ac": "A0A8C2MPQ3-1", "length": 791, "uniprot_id": "A0A8C2MPQ3_CRIGR", "protein_name": "threonine--tRNA ligase", "refseq_ac": "XP_007638354", "refseq_name": "threonine--tRNA ligase 2, cytoplasmic isoform X1", "gene_name": "Tars3", "gene_names_uniprotkb": "Tars3", "gene_names_refseq": "Tars3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MPQ3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MPQ3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GGKWPLWLSPRQVMVIPVGP", "down_seq": "CENYALQVSKECFEEGFMAD", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr697", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "697", "end_pos": "697" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MPW1-1.824.824", "start_pos": 824, "end_pos": 824, "uniprot_canonical_ac": "A0A8C2MPW1-1", "length": 1123, "uniprot_id": "A0A8C2MPW1_CRIGR", "protein_name": "tRNA (34-2'-O)-methyltransferase regulator WDR6", "refseq_ac": "XP_027240162", "refseq_name": "WD repeat-containing protein 6 isoform X1", "gene_name": "Wdr6", "gene_names_uniprotkb": "Wdr6", "gene_names_refseq": "Wdr6", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MPW1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MPW1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SAGGRAEMHCFSLMVTPDPS", "down_seq": "PSRLTCHVMHLSSHRLDEYW", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr824", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "824", "end_pos": "824" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MPY6-1.108.108", "start_pos": 108, "end_pos": 108, "uniprot_canonical_ac": "A0A8C2MPY6-1", "length": 630, "uniprot_id": "A0A8C2MPY6_CRIGR", "protein_name": "Plastin-1", "refseq_ac": "XP_035300424", "refseq_name": "plastin-1", "gene_name": "Pls1", "gene_names_uniprotkb": "Pls1", "gene_names_refseq": "Pls1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MPY6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MPY6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ISKTFRKIINKREGITAIGG", "down_seq": "SSISSEGTQHSYSDEEKVAF", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr108", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "108", "end_pos": "108" }, { "start_pos": "353", "end_pos": "353" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MPY6-1.353.353", "start_pos": 353, "end_pos": 353, "uniprot_canonical_ac": "A0A8C2MPY6-1", "length": 630, "uniprot_id": "A0A8C2MPY6_CRIGR", "protein_name": "Plastin-1", "refseq_ac": "XP_035300424", "refseq_name": "plastin-1", "gene_name": "Pls1", "gene_names_uniprotkb": "Pls1", "gene_names_refseq": "Pls1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MPY6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MPY6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LKRAGFMLQEADKLGCRQFV", "down_seq": "PADVVSGNPKLNLAFVANLF", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr353", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "108", "end_pos": "108" }, { "start_pos": "353", "end_pos": "353" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MQ28-1.1597.1597", "start_pos": 1597, "end_pos": 1597, "uniprot_canonical_ac": "A0A8C2MQ28-1", "length": 2314, "uniprot_id": "A0A8C2MQ28_CRIGR", "protein_name": "Receptor-type tyrosine-protein phosphatase zeta", "refseq_ac": "XP_027245770", "refseq_name": "receptor-type tyrosine-protein phosphatase zeta isoform X1", "gene_name": "Ptprz1", "gene_names_uniprotkb": "Ptprz1", "gene_names_refseq": "Ptprz1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MQ28", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MQ28" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ADGVLEADDTGIAPGSPRSS", "down_seq": "PSVNSGHSEVSNSSEAEASN", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1597", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1597", "end_pos": "1597" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MQ76-1.162.162", "start_pos": 162, "end_pos": 162, "uniprot_canonical_ac": "A0A8C2MQ76-1", "length": 519, "uniprot_id": "A0A8C2MQ76_CRIGR", "protein_name": "Large neutral amino acids transporter small subunit 1 isoform X1", "refseq_ac": "XP_027241923", "refseq_name": "large neutral amino acids transporter small subunit 1 isoform X1", "gene_name": "Slc7a5", "gene_names_uniprotkb": "Slc7a5", "gene_names_refseq": "Slc7a5", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MQ76", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MQ76" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SSQYIVALVFATYLLKPIFP", "down_seq": "CPVPEEAAKLVACLCVRGRW", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr162", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "162", "end_pos": "162" }, { "start_pos": "70", "end_pos": "70" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MQ76-1.70.70", "start_pos": 70, "end_pos": 70, "uniprot_canonical_ac": "A0A8C2MQ76-1", "length": 519, "uniprot_id": "A0A8C2MQ76_CRIGR", "protein_name": "Large neutral amino acids transporter small subunit 1 isoform X1", "refseq_ac": "XP_027241923", "refseq_name": "large neutral amino acids transporter small subunit 1 isoform X1", "gene_name": "Slc7a5", "gene_names_uniprotkb": "Slc7a5", "gene_names_refseq": "Slc7a5", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MQ76", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MQ76" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TLLNGVAIIVGTIIGSGIFV", "down_seq": "PTGVLKEAGSPGLALVVWAV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr70", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "162", "end_pos": "162" }, { "start_pos": "70", "end_pos": "70" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MQB4-1.184.184", "start_pos": 184, "end_pos": 184, "uniprot_canonical_ac": "A0A8C2MQB4-1", "length": 1538, "uniprot_id": "A0A8C2MQB4_CRIGR", "protein_name": "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3", "refseq_ac": "XP_027253837", "refseq_name": "arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X2", "gene_name": "Arap3", "gene_names_uniprotkb": "Arap3", "gene_names_refseq": "Arap3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MQB4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MQB4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RGSAQAAQDVTPDSSQAAVP", "down_seq": "PAFRPTVGTVHIMDPGCLYY", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr184", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "184", "end_pos": "184" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MQC8-1.478.478", "start_pos": 478, "end_pos": 478, "uniprot_canonical_ac": "A0A8C2MQC8-1", "length": 636, "uniprot_id": "A0A8C2MQC8_CRIGR", "protein_name": "Molybdenum cofactor biosynthesis protein 1", "refseq_ac": "XP_027250357", "refseq_name": "molybdenum cofactor biosynthesis protein 1 isoform X5", "gene_name": "Mocs1", "gene_names_uniprotkb": "Mocs1", "gene_names_refseq": "Mocs1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MQC8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MQC8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "HSTCLSKGSQDPAVPPGPGP", "down_seq": "STQLTHVDSEGRAAMVDVGG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr478", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "478", "end_pos": "478" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MQD6-1.1099.1099", "start_pos": 1099, "end_pos": 1099, "uniprot_canonical_ac": "A0A8C2MQD6-1", "length": 1408, "uniprot_id": "A0A8C2MQD6_CRIGR", "protein_name": "Complement component receptor 1-like protein", "refseq_ac": "XP_035292908", "refseq_name": "complement receptor type 2", "gene_name": "Cr2", "gene_names_uniprotkb": "Cr2", "gene_names_refseq": "Cr2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MQD6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MQD6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "NGIWFQKIAVCKVILCQPPP", "down_seq": "VENGRHTGMMEEHFLYGNEV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1099", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1099", "end_pos": "1099" }, { "start_pos": "519", "end_pos": "519" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MQD6-1.519.519", "start_pos": 519, "end_pos": 519, "uniprot_canonical_ac": "A0A8C2MQD6-1", "length": 1408, "uniprot_id": "A0A8C2MQD6_CRIGR", "protein_name": "Complement component receptor 1-like protein", "refseq_ac": "XP_035292908", "refseq_name": "complement receptor type 2", "gene_name": "Cr2", "gene_names_uniprotkb": "Cr2", "gene_names_refseq": "Cr2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MQD6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MQD6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "NFTMKGSRTVWCQANKMWGP", "down_seq": "PLPICESDFPLECPSLPMIH", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr519", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1099", "end_pos": "1099" }, { "start_pos": "519", "end_pos": "519" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MQJ3-1.404.404", "start_pos": 404, "end_pos": 404, "uniprot_canonical_ac": "A0A8C2MQJ3-1", "length": 423, "uniprot_id": "A0A8C2MQJ3_CRIGR", "protein_name": "F-box/LRR-repeat protein 2", "refseq_ac": "XP_027271093", "refseq_name": "F-box/LRR-repeat protein 2 isoform X2", "gene_name": "Fbxl2", "gene_names_uniprotkb": "Fbxl2", "gene_names_refseq": "Fbxl2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MQJ3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MQJ3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "IKRMRAQLPHVKVHAYFAPV", "down_seq": "PPPAVAGSGHRLCRCCVIL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr404", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "404", "end_pos": "404" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MQS8-1.983.983", "start_pos": 983, "end_pos": 983, "uniprot_canonical_ac": "A0A8C2MQS8-1", "length": 1031, "uniprot_id": "A0A8C2MQS8_CRIGR", "protein_name": "Semaphorin-6A", "refseq_ac": "XP_027256676", "refseq_name": "semaphorin-6A isoform X2", "gene_name": "Sema6a", "gene_names_uniprotkb": "Sema6a", "gene_names_refseq": "Sema6a", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MQS8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MQS8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "APQRVDSIQVHSSQPPGQAV", "down_seq": "VSRQPSLNAYNSLTRSGLKR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr983", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "983", "end_pos": "983" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MQT1-1.505.505", "start_pos": 505, "end_pos": 505, "uniprot_canonical_ac": "A0A8C2MQT1-1", "length": 765, "uniprot_id": "A0A8C2MQT1_CRIGR", "protein_name": "Disabled homolog 2 isoform X1", "refseq_ac": "XP_003503146", "refseq_name": "disabled homolog 2 isoform X1", "gene_name": "Dab2", "gene_names_uniprotkb": "Dab2", "gene_names_refseq": "Dab2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MQT1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MQT1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "FKTSAPAPMGPLAGLGGVSV", "down_seq": "PPQAGPWTPVVFSPSTSVVP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr505", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "505", "end_pos": "505" }, { "start_pos": "545", "end_pos": "545" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MQT1-1.545.545", "start_pos": 545, "end_pos": 545, "uniprot_canonical_ac": "A0A8C2MQT1-1", "length": 765, "uniprot_id": "A0A8C2MQT1_CRIGR", "protein_name": "Disabled homolog 2 isoform X1", "refseq_ac": "XP_003503146", "refseq_name": "disabled homolog 2 isoform X1", "gene_name": "Dab2", "gene_names_uniprotkb": "Dab2", "gene_names_refseq": "Dab2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MQT1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MQT1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PGAIISGQPSGFGQPIVFSA", "down_seq": "PAVQVWNQPSSFAAPASPPP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr545", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "505", "end_pos": "505" }, { "start_pos": "545", "end_pos": "545" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MQV8-1.341.341", "start_pos": 341, "end_pos": 341, "uniprot_canonical_ac": "A0A8C2MQV8-1", "length": 903, "uniprot_id": "A0A8C2MQV8_CRIGR", "protein_name": "Serine/threonine-protein phosphatase 1 regulatory subunit 10", "refseq_ac": "XP_027244361", "refseq_name": "serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1", "gene_name": "Ppp1r10", "gene_names_uniprotkb": "Ppp1r10", "gene_names_refseq": "Ppp1r10", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MQV8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MQV8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PFEGKTSTEPSSAKPSSPEP", "down_seq": "PPAEPMDTDRPGTPVPPVEV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr341", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "341", "end_pos": "341" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MRB8-1.249.249", "start_pos": 249, "end_pos": 249, "uniprot_canonical_ac": "A0A8C2MRB8-1", "length": 1082, "uniprot_id": "A0A8C2MRB8_CRIGR", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 48", "refseq_ac": "XP_027255563", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 48 isoform X8", "gene_name": "Usp48", "gene_names_uniprotkb": "Usp48", "gene_names_refseq": "Usp48", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MRB8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MRB8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "KNPDVRNIVQQQFCGEYAYV", "down_seq": "VCNQCGRESKLLSKFYELEL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr249", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "249", "end_pos": "249" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "P18708-1.207.207", "start_pos": 207, "end_pos": 207, "uniprot_canonical_ac": "P18708-1", "length": 744, "uniprot_id": "NSF_CRIGR", "protein_name": "Vesicle-fusing ATPase", "refseq_ac": "", "refseq_name": "", "gene_name": "NSF", "gene_names_uniprotkb": "NSF", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "P18708", "url": "https://www.uniprot.org/uniprotkb/P18708" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "P18708", "url": "https://www.uniprot.org/uniprotkb/P18708", "database": "UniProtKB", "categories": [ "Protein" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "KAENSSLNLIGKAKTKENRQ", "down_seq": "IINPDWNFEKMGIGGLDKEF", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P18708", "url": "https://www.uniprot.org/uniprotkb/P18708" } ], "site_lbl": "Ser207" } ], "all_sites": [ { "type": "phosphorylation", "site_list": [ { "start_pos": "207", "end_pos": "207" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "569", "end_pos": "569" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "P18708-1.259.259", "start_pos": 259, "end_pos": 259, "uniprot_canonical_ac": "P18708-1", "length": 744, "uniprot_id": "NSF_CRIGR", "protein_name": "Vesicle-fusing ATPase", "refseq_ac": "", "refseq_name": "", "gene_name": "NSF", "gene_names_uniprotkb": "NSF", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "P18708", "url": "https://www.uniprot.org/uniprotkb/P18708" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "P18708", "url": "https://www.uniprot.org/uniprotkb/P18708", "database": "UniProtKB", "categories": [ "Protein" ] } ], "site_seq": "Y", "start_aa": "Y", "up_seq": "VFPPEIVEQMGCKHVKGILL", "down_seq": "GPPGCGKTLLARQIGKMLNA", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P18708", "url": "https://www.uniprot.org/uniprotkb/P18708" } ], "site_lbl": "Tyr259" } ], "all_sites": [ { "type": "phosphorylation", "site_list": [ { "start_pos": "207", "end_pos": "207" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "569", "end_pos": "569" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "P18708-1.569.569", "start_pos": 569, "end_pos": 569, "uniprot_canonical_ac": "P18708-1", "length": 744, "uniprot_id": "NSF_CRIGR", "protein_name": "Vesicle-fusing ATPase", "refseq_ac": "", "refseq_name": "", "gene_name": "NSF", "gene_names_uniprotkb": "NSF", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "P18708", "url": "https://www.uniprot.org/uniprotkb/P18708" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "P18708", "url": "https://www.uniprot.org/uniprotkb/P18708", "database": "UniProtKB", "categories": [ "Protein" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "KTALAAKIAEESNFPFIKIC", "down_seq": "PDKMIGFSETAKCQAMKKIF", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by CDK16", "evidence": [ { "database": "UniProtKB", "id": "P18708", "url": "https://www.uniprot.org/uniprotkb/P18708" } ], "site_lbl": "Ser569" } ], "all_sites": [ { "type": "phosphorylation", "site_list": [ { "start_pos": "207", "end_pos": "207" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "569", "end_pos": "569" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QHE1-1.1063.1063", "start_pos": 1063, "end_pos": 1063, "uniprot_canonical_ac": "A0A8C2QHE1-1", "length": 1198, "uniprot_id": "A0A8C2QHE1_CRIGR", "protein_name": "Metabotropic glutamate receptor 1", "refseq_ac": "XP_035296279", "refseq_name": "metabotropic glutamate receptor 1 isoform X2", "gene_name": "Grm1", "gene_names_uniprotkb": "Grm1", "gene_names_refseq": "Grm1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QHE1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QHE1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VVTNFGAGIPDFHAVLAGPG", "down_seq": "PGNGLRSLYPPPPPPQHLQM", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1063", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1063", "end_pos": "1063" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QIW7-1.1156.1156", "start_pos": 1156, "end_pos": 1156, "uniprot_canonical_ac": "A0A8C2QIW7-1", "length": 1309, "uniprot_id": "A0A8C2QIW7_CRIGR", "protein_name": "Rab11 family-interacting protein 5", "refseq_ac": "XP_027284543", "refseq_name": "rab11 family-interacting protein 5 isoform X3", "gene_name": "Rab11fip5", "gene_names_uniprotkb": "Rab11fip5", "gene_names_refseq": "Rab11fip5", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QIW7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QIW7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LEFSPTGGSPTPYGEDRAAA", "down_seq": "PASPLALLPLETRPAEEPQL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1156", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1156", "end_pos": "1156" }, { "start_pos": "1235", "end_pos": "1235" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "577", "end_pos": "577" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QIW7-1.1235.1235", "start_pos": 1235, "end_pos": 1235, "uniprot_canonical_ac": "A0A8C2QIW7-1", "length": 1309, "uniprot_id": "A0A8C2QIW7_CRIGR", "protein_name": "Rab11 family-interacting protein 5", "refseq_ac": "XP_027284543", "refseq_name": "rab11 family-interacting protein 5 isoform X3", "gene_name": "Rab11fip5", "gene_names_uniprotkb": "Rab11fip5", "gene_names_refseq": "Rab11fip5", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QIW7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QIW7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LKTVTSGSIQSVVPASQLGP", "down_seq": "VDTKRLKDSALLDQSAKYYH", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1235", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1156", "end_pos": "1156" }, { "start_pos": "1235", "end_pos": "1235" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "577", "end_pos": "577" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QIW7-1.543.543", "start_pos": 543, "end_pos": 543, "uniprot_canonical_ac": "A0A8C2QIW7-1", "length": 1309, "uniprot_id": "A0A8C2QIW7_CRIGR", "protein_name": "Rab11 family-interacting protein 5", "refseq_ac": "XP_027284543", "refseq_name": "rab11 family-interacting protein 5 isoform X3", "gene_name": "Rab11fip5", "gene_names_uniprotkb": "Rab11fip5", "gene_names_refseq": "Rab11fip5", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QIW7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QIW7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VESDPAAPPHPCSPWALAPP", "down_seq": "PAPAAAPMLSTNLFAATSPA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr543", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1156", "end_pos": "1156" }, { "start_pos": "1235", "end_pos": "1235" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "577", "end_pos": "577" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QIW7-1.577.577", "start_pos": 577, "end_pos": 577, "uniprot_canonical_ac": "A0A8C2QIW7-1", "length": 1309, "uniprot_id": "A0A8C2QIW7_CRIGR", "protein_name": "Rab11 family-interacting protein 5", "refseq_ac": "XP_027284543", "refseq_name": "rab11 family-interacting protein 5 isoform X3", "gene_name": "Rab11fip5", "gene_names_uniprotkb": "Rab11fip5", "gene_names_refseq": "Rab11fip5", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QIW7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QIW7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "FAATSPAAATAAAATIVPGA", "down_seq": "PSGFLGVTNPFLTSLQSNPF", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr577", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1156", "end_pos": "1156" }, { "start_pos": "1235", "end_pos": "1235" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "577", "end_pos": "577" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QIW7-1.981.981", "start_pos": 981, "end_pos": 981, "uniprot_canonical_ac": "A0A8C2QIW7-1", "length": 1309, "uniprot_id": "A0A8C2QIW7_CRIGR", "protein_name": "Rab11 family-interacting protein 5", "refseq_ac": "XP_027284543", "refseq_name": "rab11 family-interacting protein 5 isoform X3", "gene_name": "Rab11fip5", "gene_names_uniprotkb": "Rab11fip5", "gene_names_refseq": "Rab11fip5", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QIW7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QIW7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LEELVGDTGAPGSGAFPPSP", "down_seq": "SCLEGPIPRSRSSPSSTLLS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr981", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1156", "end_pos": "1156" }, { "start_pos": "1235", "end_pos": "1235" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "577", "end_pos": "577" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QM40-1.661.661", "start_pos": 661, "end_pos": 661, "uniprot_canonical_ac": "A0A8C2QM40-1", "length": 868, "uniprot_id": "A0A8C2QM40_CRIGR", "protein_name": "Lethal(3)malignant brain tumor-like protein 3 isoform X2", "refseq_ac": "XP_027258676", "refseq_name": "lethal(3)malignant brain tumor-like protein 3 isoform X2", "gene_name": "L3mbtl3", "gene_names_uniprotkb": "L3mbtl3", "gene_names_refseq": "L3mbtl3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QM40", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QM40" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AEKRENEVRTSEAKVVREEP", "down_seq": "PTIHQAQQVQQAQHVQQVQQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr661", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "661", "end_pos": "661" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MRL6-1.726.726", "start_pos": 726, "end_pos": 726, "uniprot_canonical_ac": "A0A8C2MRL6-1", "length": 997, "uniprot_id": "A0A8C2MRL6_CRIGR", "protein_name": "Kinesin-like protein", "refseq_ac": "XP_027281554", "refseq_name": "kinesin-like protein KIF19 isoform X2", "gene_name": "Kif19", "gene_names_uniprotkb": "Kif19", "gene_names_refseq": "Kif19", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MRL6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MRL6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SYHVFKASPRAWQAKNSSVP", "down_seq": "PPPIQVGTLVTQQAPPQDSL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr726", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "726", "end_pos": "726" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MRN2-1.763.763", "start_pos": 763, "end_pos": 763, "uniprot_canonical_ac": "A0A8C2MRN2-1", "length": 811, "uniprot_id": "A0A8C2MRN2_CRIGR", "protein_name": "Phosphoinositide 3-kinase adapter protein 1", "refseq_ac": "XP_027263137", "refseq_name": "phosphoinositide 3-kinase adapter protein 1 isoform X2", "gene_name": "Pik3ap1", "gene_names_uniprotkb": "Pik3ap1", "gene_names_refseq": "Pik3ap1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MRN2", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MRN2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EGDNEDNEVPEITRSRSPGP", "down_seq": "QMDGAPAVTGTPVMTLERPP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr763", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "763", "end_pos": "763" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MS13-1.194.194", "start_pos": 194, "end_pos": 194, "uniprot_canonical_ac": "A0A8C2MS13-1", "length": 544, "uniprot_id": "A0A8C2MS13_CRIGR", "protein_name": "Autoimmune regulator", "refseq_ac": "XP_035307526", "refseq_name": "autoimmune regulator isoform X2", "gene_name": "Aire", "gene_names_uniprotkb": "Aire", "gene_names_refseq": "Aire", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MS13", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MS13" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QRLPLGNGIQAMSASVQRAV", "down_seq": "VSSGEVPGTRGAVEGILIQQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr194", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "194", "end_pos": "194" }, { "start_pos": "476", "end_pos": "476" }, { "start_pos": "478", "end_pos": "478" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MS13-1.476.476", "start_pos": 476, "end_pos": 476, "uniprot_canonical_ac": "A0A8C2MS13-1", "length": 544, "uniprot_id": "A0A8C2MS13_CRIGR", "protein_name": "Autoimmune regulator", "refseq_ac": "XP_035307526", "refseq_name": "autoimmune regulator isoform X2", "gene_name": "Aire", "gene_names_uniprotkb": "Aire", "gene_names_refseq": "Aire", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MS13", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MS13" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PMAAARPGTNPRCKSCSADP", "down_seq": "PTPGEAAPTSARPAPVLAKV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr476", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "194", "end_pos": "194" }, { "start_pos": "476", "end_pos": "476" }, { "start_pos": "478", "end_pos": "478" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "upstream", "id": "A0A8C2MS13-1.478.478", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MS13-1.478.478", "start_pos": 478, "end_pos": 478, "uniprot_canonical_ac": "A0A8C2MS13-1", "length": 544, "uniprot_id": "A0A8C2MS13_CRIGR", "protein_name": "Autoimmune regulator", "refseq_ac": "XP_035307526", "refseq_name": "autoimmune regulator isoform X2", "gene_name": "Aire", "gene_names_uniprotkb": "Aire", "gene_names_refseq": "Aire", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MS13", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MS13" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AAARPGTNPRCKSCSADPTP", "down_seq": "PGEAAPTSARPAPVLAKVGD", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr478", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "194", "end_pos": "194" }, { "start_pos": "476", "end_pos": "476" }, { "start_pos": "478", "end_pos": "478" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "downstream", "id": "A0A8C2MS13-1.476.476", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MS37-1.289.289", "start_pos": 289, "end_pos": 289, "uniprot_canonical_ac": "A0A8C2MS37-1", "length": 1141, "uniprot_id": "A0A8C2MS37_CRIGR", "protein_name": "Nucleolar protein 6", "refseq_ac": "XP_027259159", "refseq_name": "nucleolar protein 6 isoform X2", "gene_name": "Nol6", "gene_names_uniprotkb": "Nol6", "gene_names_refseq": "Nol6", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MS37", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MS37" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VRSAWYRGQSAPESASPEPP", "down_seq": "PHYNTWILQDTVLESQMHLL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr289", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "289", "end_pos": "289" }, { "start_pos": "697", "end_pos": "697" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MS37-1.697.697", "start_pos": 697, "end_pos": 697, "uniprot_canonical_ac": "A0A8C2MS37-1", "length": 1141, "uniprot_id": "A0A8C2MS37_CRIGR", "protein_name": "Nucleolar protein 6", "refseq_ac": "XP_027259159", "refseq_name": "nucleolar protein 6 isoform X2", "gene_name": "Nol6", "gene_names_uniprotkb": "Nol6", "gene_names_refseq": "Nol6", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MS37", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MS37" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TVSAVQGAHPVLRYTEVFPP", "down_seq": "PVRPAYSFHKHLQERASLLP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr697", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "289", "end_pos": "289" }, { "start_pos": "697", "end_pos": "697" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MSD9-1.238.238", "start_pos": 238, "end_pos": 238, "uniprot_canonical_ac": "A0A8C2MSD9-1", "length": 393, "uniprot_id": "A0A8C2MSD9_CRIGR", "protein_name": "Branched-chain-amino-acid aminotransferase", "refseq_ac": "XP_027276410", "refseq_name": "branched-chain-amino-acid aminotransferase, mitochondrial isoform X3", "gene_name": "Bcat2", "gene_names_uniprotkb": "Bcat2", "gene_names_refseq": "Bcat2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MSD9", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MSD9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "FIRAWMGGVGDYKLGGNYGP", "down_seq": "VAVQQTAQEKGCEQVLWLYG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr238", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "238", "end_pos": "238" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MT53-1.368.368", "start_pos": 368, "end_pos": 368, "uniprot_canonical_ac": "A0A8C2MT53-1", "length": 481, "uniprot_id": "A0A8C2MT53_CRIGR", "protein_name": "Hyaluronidase", "refseq_ac": "XP_035306777", "refseq_name": "hyaluronidase-4", "gene_name": "LOC100758272", "gene_names_uniprotkb": "LOC100758272", "gene_names_refseq": "LOC100758272", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MT53", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MT53" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A8C2MT53", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MT53", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR038193-2", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038193-2", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "EENCTKVNHFVNSDFGNYII", "down_seq": "VSTAAEVCSHHLCKNNGRCI", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn368", "evidence": [ { "id": "A0A8C2MT53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MT53#ptm_processing" }, { "id": "PIRSR038193-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038193-2" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "368", "end_pos": "368" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MTH0-1.289.289", "start_pos": 289, "end_pos": 289, "uniprot_canonical_ac": "A0A8C2MTH0-1", "length": 862, "uniprot_id": "A0A8C2MTH0_CRIGR", "protein_name": "Xylosyltransferase 2", "refseq_ac": "XP_003501404", "refseq_name": "xylosyltransferase 2 isoform X1", "gene_name": "Xylt2", "gene_names_uniprotkb": "Xylt2", "gene_names_refseq": "Xylt2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MTH0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MTH0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SNYLYQEVVELARHYDNVRV", "down_seq": "PWRMVTIWGGASLLRMYLRS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr289", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "289", "end_pos": "289" }, { "start_pos": "529", "end_pos": "529" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MTH0-1.529.529", "start_pos": 529, "end_pos": 529, "uniprot_canonical_ac": "A0A8C2MTH0-1", "length": 862, "uniprot_id": "A0A8C2MTH0_CRIGR", "protein_name": "Xylosyltransferase 2", "refseq_ac": "XP_003501404", "refseq_name": "xylosyltransferase 2 isoform X1", "gene_name": "Xylt2", "gene_names_uniprotkb": "Xylt2", "gene_names_refseq": "Xylt2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MTH0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MTH0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VNQEVLEILDFHLYGSYPPS", "down_seq": "PALKAYWENTYDVADGPSGL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr529", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "289", "end_pos": "289" }, { "start_pos": "529", "end_pos": "529" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MTM6-1.377.377", "start_pos": 377, "end_pos": 377, "uniprot_canonical_ac": "A0A8C2MTM6-1", "length": 543, "uniprot_id": "A0A8C2MTM6_CRIGR", "protein_name": "Zona pellucida sperm-binding protein 4", "refseq_ac": "XP_003505312", "refseq_name": "zona pellucida sperm-binding protein 4", "gene_name": "Zp4", "gene_names_uniprotkb": "Zp4", "gene_names_refseq": "Zp4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MTM6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MTM6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VSILHRTDPSLELLLEQCWA", "down_seq": "PGPNPFNQPQWPILVKGCPY", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr377", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "377", "end_pos": "377" }, { "start_pos": "458", "end_pos": "458" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MTM6-1.458.458", "start_pos": 458, "end_pos": 458, "uniprot_canonical_ac": "A0A8C2MTM6-1", "length": 543, "uniprot_id": "A0A8C2MTM6_CRIGR", "protein_name": "Zona pellucida sperm-binding protein 4", "refseq_ac": "XP_003505312", "refseq_name": "zona pellucida sperm-binding protein 4", "gene_name": "Zp4", "gene_names_uniprotkb": "Zp4", "gene_names_refseq": "Zp4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MTM6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MTM6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QAFGGQVYLHCSALVCQPAG", "down_seq": "PSCMAICPASRRRRKSELYF", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr458", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "377", "end_pos": "377" }, { "start_pos": "458", "end_pos": "458" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MTQ0-1.11.11", "start_pos": 11, "end_pos": 11, "uniprot_canonical_ac": "A0A8C2MTQ0-1", "length": 1038, "uniprot_id": "A0A8C2MTQ0_CRIGR", "protein_name": "Protein phosphatase Slingshot homolog 1", "refseq_ac": "XP_027271770", "refseq_name": "protein phosphatase Slingshot homolog 1 isoform X2", "gene_name": "Ssh1", "gene_names_uniprotkb": "Ssh1", "gene_names_refseq": "Ssh1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MTQ0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MTQ0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MALVTLQRSP", "down_seq": "PSAASSSASNSELEAGSDEE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr11", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "11", "end_pos": "11" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MU62-1.226.226", "start_pos": 226, "end_pos": 226, "uniprot_canonical_ac": "A0A8C2MU62-1", "length": 966, "uniprot_id": "A0A8C2MU62_CRIGR", "protein_name": "Neutral alpha-glucosidase AB", "refseq_ac": "XP_003508783", "refseq_name": "neutral alpha-glucosidase AB isoform X1", "gene_name": "Ganab", "gene_names_uniprotkb": "Ganab", "gene_names_refseq": "Ganab", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MU62", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MU62" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LFSRQESKDPAEGNGAQPEA", "down_seq": "PGDGDQPEETQEKAEKDEPG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr226", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "226", "end_pos": "226" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MU65-1.921.921", "start_pos": 921, "end_pos": 921, "uniprot_canonical_ac": "A0A8C2MU65-1", "length": 1868, "uniprot_id": "A0A8C2MU65_CRIGR", "protein_name": "Dedicator of cytokinesis protein 5 isoform X1", "refseq_ac": "XP_007646042", "refseq_name": "dedicator of cytokinesis protein 5 isoform X1", "gene_name": "Dock5", "gene_names_uniprotkb": "Dock5", "gene_names_refseq": "Dock5", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MU65", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MU65" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ASSQLLSNILEVLDRKDVGP", "down_seq": "STHVQLIMERLLRRINRTVI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr921", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "921", "end_pos": "921" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MUD5-1.135.135", "start_pos": 135, "end_pos": 135, "uniprot_canonical_ac": "A0A8C2MUD5-1", "length": 516, "uniprot_id": "A0A8C2MUD5_CRIGR", "protein_name": "Autophagy-related protein 13", "refseq_ac": "XP_016820706", "refseq_name": "autophagy-related protein 13 isoform X1", "gene_name": "Atg13", "gene_names_uniprotkb": "Atg13", "gene_names_refseq": "Atg13", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MUD5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MUD5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "YTVYNRLSLLLKSLLAITRV", "down_seq": "PAYRLSRKQGHEYVILYRIY", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr135", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "135", "end_pos": "135" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MV78-1.113.113", "start_pos": 113, "end_pos": 113, "uniprot_canonical_ac": "A0A8C2MV78-1", "length": 640, "uniprot_id": "A0A8C2MV78_CRIGR", "protein_name": "dual-specificity kinase", "refseq_ac": "", "refseq_name": "", "gene_name": "Clk3", "gene_names_uniprotkb": "Clk3", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MV78", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MV78" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ACELGARAARPLGRVEPGPP", "down_seq": "AASREGAVLPRAEAGAGSGR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr113", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "113", "end_pos": "113" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MV81-1.654.654", "start_pos": 654, "end_pos": 654, "uniprot_canonical_ac": "A0A8C2MV81-1", "length": 704, "uniprot_id": "A0A8C2MV81_CRIGR", "protein_name": "procollagen-proline 3-dioxygenase", "refseq_ac": "XP_027268752", "refseq_name": "prolyl 3-hydroxylase 2 isoform X2", "gene_name": "P3h2", "gene_names_uniprotkb": "P3h2", "gene_names_refseq": "P3h2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MV81", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MV81" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "CGRMISFSSGGENPHGVKAV", "down_seq": "RGQRCAVALWFTLDPLYREV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr654", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "654", "end_pos": "654" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MVE8-1.590.590", "start_pos": 590, "end_pos": 590, "uniprot_canonical_ac": "A0A8C2MVE8-1", "length": 1456, "uniprot_id": "A0A8C2MVE8_CRIGR", "protein_name": "Collagen alpha-1(XVII) chain", "refseq_ac": "XP_027262862", "refseq_name": "collagen alpha-1(XVII) chain isoform X2", "gene_name": "Col17a1", "gene_names_uniprotkb": "Col17a1", "gene_names_refseq": "Col17a1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MVE8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MVE8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PGPKGDMGSQGPKGDRGLPG", "down_seq": "PGIPGPLGHPGPEGPKGQKG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr590", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "590", "end_pos": "590" }, { "start_pos": "838", "end_pos": "838" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MVE8-1.838.838", "start_pos": 838, "end_pos": 838, "uniprot_canonical_ac": "A0A8C2MVE8-1", "length": 1456, "uniprot_id": "A0A8C2MVE8_CRIGR", "protein_name": "Collagen alpha-1(XVII) chain", "refseq_ac": "XP_027262862", "refseq_name": "collagen alpha-1(XVII) chain isoform X2", "gene_name": "Col17a1", "gene_names_uniprotkb": "Col17a1", "gene_names_refseq": "Col17a1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MVE8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MVE8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ITVPGPPGPPGAMGPPGPPG", "down_seq": "PGPAGPAGLPGQQGPRGEPG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr838", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "590", "end_pos": "590" }, { "start_pos": "838", "end_pos": "838" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MVG7-1.71.71", "start_pos": 71, "end_pos": 71, "uniprot_canonical_ac": "A0A8C2MVG7-1", "length": 1197, "uniprot_id": "A0A8C2MVG7_CRIGR", "protein_name": "Solute carrier family 12 member 2 isoform X2", "refseq_ac": "XP_027256738", "refseq_name": "solute carrier family 12 member 2 isoform X2", "gene_name": "Slc12a2", "gene_names_uniprotkb": "Slc12a2", "gene_names_refseq": "Slc12a2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MVG7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MVG7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GVRGDGAAAGGDGLGRPLGP", "down_seq": "PSQSRFQVDVVSENAGRAAA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr71", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "71", "end_pos": "71" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MVH2-1.406.406", "start_pos": 406, "end_pos": 406, "uniprot_canonical_ac": "A0A8C2MVH2-1", "length": 984, "uniprot_id": "A0A8C2MVH2_CRIGR", "protein_name": "LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase-like N isoform X2", "refseq_ac": "XP_027253093", "refseq_name": "LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase-like N isoform X2", "gene_name": "LOC100768982", "gene_names_uniprotkb": "LOC100768982", "gene_names_refseq": "LOC100768982", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MVH2", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MVH2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VKKTTEEQMQKGDAADPRPP", "down_seq": "PSLPGHPTVSPTSNEVQQML", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr406", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "406", "end_pos": "406" }, { "start_pos": "885", "end_pos": "885" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MVH2-1.885.885", "start_pos": 885, "end_pos": 885, "uniprot_canonical_ac": "A0A8C2MVH2-1", "length": 984, "uniprot_id": "A0A8C2MVH2_CRIGR", "protein_name": "LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase-like N isoform X2", "refseq_ac": "XP_027253093", "refseq_name": "LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase-like N isoform X2", "gene_name": "LOC100768982", "gene_names_uniprotkb": "LOC100768982", "gene_names_refseq": "LOC100768982", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MVH2", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MVH2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QTQETRTLTQFHFLSWPAEG", "down_seq": "PASTRPLLDFRRKVNKCYRG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr885", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "406", "end_pos": "406" }, { "start_pos": "885", "end_pos": "885" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MVI4-1.520.520", "start_pos": 520, "end_pos": 520, "uniprot_canonical_ac": "A0A8C2MVI4-1", "length": 1086, "uniprot_id": "A0A8C2MVI4_CRIGR", "protein_name": "NAD(P) transhydrogenase, mitochondrial", "refseq_ac": "XP_003515231", "refseq_name": "NAD(P) transhydrogenase, mitochondrial isoform X2", "gene_name": "Nnt", "gene_names_uniprotkb": "Nnt", "gene_names_refseq": "LOC100766566", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MVI4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MVI4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QMVTTFGLAGIIGYHTVWGV", "down_seq": "PALHSPLMSVTNAISGLTAV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr520", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "520", "end_pos": "520" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MVT0-1.371.371", "start_pos": 371, "end_pos": 371, "uniprot_canonical_ac": "A0A8C2MVT0-1", "length": 426, "uniprot_id": "A0A8C2MVT0_CRIGR", "protein_name": "ADP-ribosylation factor-like protein 13B isoform X1", "refseq_ac": "XP_003497318", "refseq_name": "ADP-ribosylation factor-like protein 13B isoform X1", "gene_name": "Arl13b", "gene_names_uniprotkb": "Arl13b", "gene_names_refseq": "Arl13b", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MVT0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MVT0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MKRSHRVEPVNTDESAPKSP", "down_seq": "PPPPPPPVGWGTPRVTRLPK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr371", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "371", "end_pos": "371" }, { "start_pos": "52", "end_pos": "52" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MVT0-1.52.52", "start_pos": 52, "end_pos": 52, "uniprot_canonical_ac": "A0A8C2MVT0-1", "length": 426, "uniprot_id": "A0A8C2MVT0_CRIGR", "protein_name": "ADP-ribosylation factor-like protein 13B isoform X1", "refseq_ac": "XP_003497318", "refseq_name": "ADP-ribosylation factor-like protein 13B isoform X1", "gene_name": "Arl13b", "gene_names_uniprotkb": "Arl13b", "gene_names_refseq": "Arl13b", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MVT0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MVT0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AGKTATAKGIQGEHPEDVAP", "down_seq": "VGFSKIDLRQGKFEVTIFDL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr52", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "371", "end_pos": "371" }, { "start_pos": "52", "end_pos": "52" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MVV7-1.86.86", "start_pos": 86, "end_pos": 86, "uniprot_canonical_ac": "A0A8C2MVV7-1", "length": 677, "uniprot_id": "A0A8C2MVV7_CRIGR", "protein_name": "Pannexin", "refseq_ac": "XP_027252027", "refseq_name": "pannexin-2 isoform X2", "gene_name": "Panx2", "gene_names_uniprotkb": "Panx2; PANX", "gene_names_refseq": "Panx2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MVV7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MVV7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A8C2MVV7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MVV7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR600990-52", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR600990-52", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "VTLVFTKNFAEEPIYCYTPH", "down_seq": "FTRDQALYARGYCWTELRDA", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn86", "evidence": [ { "id": "A0A8C2MVV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MVV7#ptm_processing" }, { "id": "PIRSR600990-52", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR600990-52" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "86", "end_pos": "86" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MW12-1.357.357", "start_pos": 357, "end_pos": 357, "uniprot_canonical_ac": "A0A8C2MW12-1", "length": 464, "uniprot_id": "A0A8C2MW12_CRIGR", "protein_name": "GDNF family receptor alpha-2", "refseq_ac": "XP_027245968", "refseq_name": "GDNF family receptor alpha-2 isoform X2", "gene_name": "Gfra2", "gene_names_uniprotkb": "Gfra2", "gene_names_refseq": "Gfra2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MW12", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MW12" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A8C2MW12", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MW12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR038071-2", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038071-2", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "KFLRDFTENPCLRNAIQAFG", "down_seq": "GTDVNMSPKGPSFPATQAPR", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn357", "evidence": [ { "id": "A0A8C2MW12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MW12#ptm_processing" }, { "id": "PIRSR038071-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038071-2" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "357", "end_pos": "357" }, { "start_pos": "413", "end_pos": "413" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MW12-1.413.413", "start_pos": 413, "end_pos": 413, "uniprot_canonical_ac": "A0A8C2MW12-1", "length": 464, "uniprot_id": "A0A8C2MW12_CRIGR", "protein_name": "GDNF family receptor alpha-2", "refseq_ac": "XP_027245968", "refseq_name": "GDNF family receptor alpha-2 isoform X2", "gene_name": "Gfra2", "gene_names_uniprotkb": "Gfra2", "gene_names_refseq": "Gfra2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MW12", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MW12" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A8C2MW12", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MW12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR038071-2", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038071-2", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "SLGTSVITTCTSIQEQGLKA", "down_seq": "NSKELSMCFTELTTNISPGS", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn413", "evidence": [ { "id": "A0A8C2MW12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MW12#ptm_processing" }, { "id": "PIRSR038071-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038071-2" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "357", "end_pos": "357" }, { "start_pos": "413", "end_pos": "413" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MW70-1.380.380", "start_pos": 380, "end_pos": 380, "uniprot_canonical_ac": "A0A8C2MW70-1", "length": 433, "uniprot_id": "A0A8C2MW70_CRIGR", "protein_name": "Voltage-gated potassium channel regulatory subunit KCNG3", "refseq_ac": "XP_035300776", "refseq_name": "potassium voltage-gated channel subfamily G member 3 isoform X2", "gene_name": "Kcng3", "gene_names_uniprotkb": "Kcng3", "gene_names_refseq": "Kcng3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MW70", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MW70" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ACWWVIISMTTVGYGDMYPI", "down_seq": "VPGRILGGVCVVSGIVLLAL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr380", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "380", "end_pos": "380" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MWA6-1.40.40", "start_pos": 40, "end_pos": 40, "uniprot_canonical_ac": "A0A8C2MWA6-1", "length": 159, "uniprot_id": "A0A8C2MWA6_CRIGR", "protein_name": "Succinate dehydrogenase [ubiquinone] cytochrome b small subunit", "refseq_ac": "XP_003498583", "refseq_name": "succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial", "gene_name": "Sdhd", "gene_names_uniprotkb": "Sdhd", "gene_names_refseq": "Sdhd", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MWA6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MWA6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LLRSRVVKPAYVSAFLQDQP", "down_seq": "PGWHGTQHIHLSPSYHSGSK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr40", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "40", "end_pos": "40" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MWI4-1.68.68", "start_pos": 68, "end_pos": 68, "uniprot_canonical_ac": "A0A8C2MWI4-1", "length": 850, "uniprot_id": "A0A8C2MWI4_CRIGR", "protein_name": "Disks large homolog 3 isoform X1", "refseq_ac": "XP_027287540", "refseq_name": "disks large homolog 3 isoform X1", "gene_name": "Dlg3", "gene_names_uniprotkb": "Dlg3", "gene_names_refseq": "Dlg3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MWI4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MWI4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SSSYGGYSSQTLPSQAGATP", "down_seq": "PRTKAKLIPTGRDVGPVPPK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr68", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "68", "end_pos": "68" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MX93-1.539.539", "start_pos": 539, "end_pos": 539, "uniprot_canonical_ac": "A0A8C2MX93-1", "length": 739, "uniprot_id": "A0A8C2MX93_CRIGR", "protein_name": "Poly(A) polymerase", "refseq_ac": "XP_027272145", "refseq_name": "poly(A) polymerase alpha isoform X6", "gene_name": "LOC107980407; Papola", "gene_names_uniprotkb": "LOC107980407; Papola", "gene_names_refseq": "Papola", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MX93", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MX93" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "NDSSLDLSMDSDNSMSVPSP", "down_seq": "SAMKTSPLNSSGSSQGRNSP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr539", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "539", "end_pos": "539" }, { "start_pos": "564", "end_pos": "564" }, { "start_pos": "611", "end_pos": "611" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MX93-1.564.564", "start_pos": 564, "end_pos": 564, "uniprot_canonical_ac": "A0A8C2MX93-1", "length": 739, "uniprot_id": "A0A8C2MX93_CRIGR", "protein_name": "Poly(A) polymerase", "refseq_ac": "XP_027272145", "refseq_name": "poly(A) polymerase alpha isoform X6", "gene_name": "LOC107980407; Papola", "gene_names_uniprotkb": "LOC107980407; Papola", "gene_names_refseq": "Papola", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MX93", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MX93" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TSPLNSSGSSQGRNSPAPAV", "down_seq": "AASVTSIQASEVSVPQANSS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr564", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "539", "end_pos": "539" }, { "start_pos": "564", "end_pos": "564" }, { "start_pos": "611", "end_pos": "611" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MX93-1.611.611", "start_pos": 611, "end_pos": 611, "uniprot_canonical_ac": "A0A8C2MX93-1", "length": 739, "uniprot_id": "A0A8C2MX93_CRIGR", "protein_name": "Poly(A) polymerase", "refseq_ac": "XP_027272145", "refseq_name": "poly(A) polymerase alpha isoform X6", "gene_name": "LOC107980407; Papola", "gene_names_uniprotkb": "LOC107980407; Papola", "gene_names_refseq": "Papola", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MX93", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MX93" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SSESIPQTATQPAISPPPKP", "down_seq": "VSRVVSSTRLVNPSPRPSGN", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr611", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "539", "end_pos": "539" }, { "start_pos": "564", "end_pos": "564" }, { "start_pos": "611", "end_pos": "611" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MXJ3-1.677.677", "start_pos": 677, "end_pos": 677, "uniprot_canonical_ac": "A0A8C2MXJ3-1", "length": 825, "uniprot_id": "A0A8C2MXJ3_CRIGR", "protein_name": "AP-1 complex subunit gamma", "refseq_ac": "XP_007639956", "refseq_name": "AP-1 complex subunit gamma-1 isoform X1", "gene_name": "Ap1g1", "gene_names_uniprotkb": "Ap1g1", "gene_names_refseq": "Ap1g1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MXJ3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MXJ3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GELLDLLGDITLTGAPAAAP", "down_seq": "PASVPQISQPPFLLDGLSSQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr677", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "677", "end_pos": "677" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MXP6-1.458.458", "start_pos": 458, "end_pos": 458, "uniprot_canonical_ac": "A0A8C2MXP6-1", "length": 499, "uniprot_id": "A0A8C2MXP6_CRIGR", "protein_name": "Actin nucleation-promoting factor WASL", "refseq_ac": "XP_003502169", "refseq_name": "neural Wiskott-Aldrich syndrome protein isoform X1", "gene_name": "Wasl", "gene_names_uniprotkb": "Wasl", "gene_names_refseq": "Wasl", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MXP6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MXP6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GIQLKSVSDGQESTPPAPAP", "down_seq": "SGIVGALMEVMQKRSKAIHS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr458", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "458", "end_pos": "458" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MXZ7-1.25.25", "start_pos": 25, "end_pos": 25, "uniprot_canonical_ac": "A0A8C2MXZ7-1", "length": 380, "uniprot_id": "A0A8C2MXZ7_CRIGR", "protein_name": "Visual system homeobox 2", "refseq_ac": "XP_027274458", "refseq_name": "visual system homeobox 2 isoform X1", "gene_name": "Vsx2", "gene_names_uniprotkb": "Vsx2", "gene_names_refseq": "Vsx2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MXZ7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MXZ7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AGETLSKPKSETVAKSTSGV", "down_seq": "PARCTGFGIQEILGLNKEPP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr25", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "25", "end_pos": "25" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MYB7-1.36.36", "start_pos": 36, "end_pos": 36, "uniprot_canonical_ac": "A0A8C2MYB7-1", "length": 671, "uniprot_id": "A0A8C2MYB7_CRIGR", "protein_name": "Xaa-Pro aminopeptidase 1", "refseq_ac": "XP_027262838", "refseq_name": "xaa-Pro aminopeptidase 1 isoform X2", "gene_name": "Xpnpep1", "gene_names_uniprotkb": "Xpnpep1", "gene_names_refseq": "Xpnpep1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MYB7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MYB7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RAYHQDFQLRNLRIIEPNEV", "down_seq": "PSGDKSVERDHRMAPKVTSE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr36", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "36", "end_pos": "36" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MYH0-1.24.24", "start_pos": 24, "end_pos": 24, "uniprot_canonical_ac": "A0A8C2MYH0-1", "length": 766, "uniprot_id": "A0A8C2MYH0_CRIGR", "protein_name": "non-specific serine/threonine protein kinase", "refseq_ac": "XP_027276012", "refseq_name": "serine/threonine-protein kinase tousled-like 1 isoform X5", "gene_name": "Tlk1", "gene_names_uniprotkb": "Tlk1", "gene_names_refseq": "Tlk1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MYH0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MYH0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QSSSGSLEGPPSWSRLSTSP", "down_seq": "PGSAAAARSLLNHTPPSGRP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr24", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "24", "end_pos": "24" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MYZ2-1.101.101", "start_pos": 101, "end_pos": 101, "uniprot_canonical_ac": "A0A8C2MYZ2-1", "length": 323, "uniprot_id": "A0A8C2MYZ2_CRIGR", "protein_name": "Aquaporin-4", "refseq_ac": "XP_027260175", "refseq_name": "aquaporin-4 isoform X1", "gene_name": "Aqp4", "gene_names_uniprotkb": "Aqp4", "gene_names_refseq": "Aqp4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MYZ2", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MYZ2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "IATMVQCFGHISGGHINPAV", "down_seq": "VAMVCTRKISIAKSVFYIAA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr101", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "101", "end_pos": "101" }, { "start_pos": "137", "end_pos": "137" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MYZ2-1.137.137", "start_pos": 137, "end_pos": 137, "uniprot_canonical_ac": "A0A8C2MYZ2-1", "length": 323, "uniprot_id": "A0A8C2MYZ2_CRIGR", "protein_name": "Aquaporin-4", "refseq_ac": "XP_027260175", "refseq_name": "aquaporin-4 isoform X1", "gene_name": "Aqp4", "gene_names_uniprotkb": "Aqp4", "gene_names_refseq": "Aqp4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MYZ2", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MYZ2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "FYIAAQCLGAIIGAGILYLV", "down_seq": "PPSVVGGLGVTTVHGNLTAG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr137", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "101", "end_pos": "101" }, { "start_pos": "137", "end_pos": "137" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MZ43-1.626.626", "start_pos": 626, "end_pos": 626, "uniprot_canonical_ac": "A0A8C2MZ43-1", "length": 1443, "uniprot_id": "A0A8C2MZ43_CRIGR", "protein_name": "Receptor-type tyrosine-protein phosphatase gamma", "refseq_ac": "XP_027245150", "refseq_name": "receptor-type tyrosine-protein phosphatase gamma isoform X2", "gene_name": "Ptprg", "gene_names_uniprotkb": "Ptprg", "gene_names_refseq": "Ptprg", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MZ43", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MZ43" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "KEKSEATHTAEERNRTAPAP", "down_seq": "PSSPRRTAEEGGHQTIPGHK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr626", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "626", "end_pos": "626" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MZA1-1.17.17", "start_pos": 17, "end_pos": 17, "uniprot_canonical_ac": "A0A8C2MZA1-1", "length": 182, "uniprot_id": "A0A8C2MZA1_CRIGR", "protein_name": "Histone deacetylase complex subunit SAP30L", "refseq_ac": "XP_007641623", "refseq_name": "histone deacetylase complex subunit SAP30L isoform X1", "gene_name": "Sap30l", "gene_names_uniprotkb": "Sap30l", "gene_names_refseq": "Sap30l", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MZA1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MZA1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MNGFSTEEDSREGPPA", "down_seq": "PAAAPGYGQSCCLIADGERC", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr17", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "17", "end_pos": "17" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MZI8-1.489.489", "start_pos": 489, "end_pos": 489, "uniprot_canonical_ac": "A0A8C2MZI8-1", "length": 757, "uniprot_id": "A0A8C2MZI8_CRIGR", "protein_name": "Oxysterol-binding protein", "refseq_ac": "XP_027268610", "refseq_name": "oxysterol-binding protein-related protein 11 isoform X2", "gene_name": "Osbpl11", "gene_names_uniprotkb": "Osbpl11", "gene_names_refseq": "Osbpl11", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MZI8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MZI8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "HCSWRIPKSEMASGLSGNSS", "down_seq": "PAITNHAPLLEDALTQGVSD", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr489", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "489", "end_pos": "489" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MZN1-1.77.77", "start_pos": 77, "end_pos": 77, "uniprot_canonical_ac": "A0A8C2MZN1-1", "length": 549, "uniprot_id": "A0A8C2MZN1_CRIGR", "protein_name": "Protein spinster homolog 2 isoform X2", "refseq_ac": "XP_027282626", "refseq_name": "protein spinster homolog 2 isoform X2", "gene_name": "Spns2", "gene_names_uniprotkb": "Spns2", "gene_names_refseq": "Spns2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MZN1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MZN1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VQTLSGSVRRVPSGLPSIPS", "down_seq": "PGCAAAAKGPGAPQPKPASL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr77", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "77", "end_pos": "77" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MZV9-1.324.324", "start_pos": 324, "end_pos": 324, "uniprot_canonical_ac": "A0A8C2MZV9-1", "length": 1012, "uniprot_id": "A0A8C2MZV9_CRIGR", "protein_name": "Metalloendopeptidase", "refseq_ac": "XP_027263273", "refseq_name": "tolloid-like protein 2", "gene_name": "Tll2", "gene_names_uniprotkb": "Tll2", "gene_names_refseq": "Tll2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MZV9", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MZV9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SRGVFLDTILPRRDDNGVRP", "down_seq": "IGQRVRLSQGDIAQARKLYK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr324", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "324", "end_pos": "324" }, { "start_pos": "381", "end_pos": "381" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MZV9-1.381.381", "start_pos": 381, "end_pos": 381, "uniprot_canonical_ac": "A0A8C2MZV9-1", "length": 1012, "uniprot_id": "A0A8C2MZV9_CRIGR", "protein_name": "Metalloendopeptidase", "refseq_ac": "XP_027263273", "refseq_name": "tolloid-like protein 2", "gene_name": "Tll2", "gene_names_uniprotkb": "Tll2", "gene_names_refseq": "Tll2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MZV9", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MZV9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "APGFPNGYPSYSHCVWRISV", "down_seq": "PGEKIILNFTSMDLFKSRLC", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr381", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "324", "end_pos": "324" }, { "start_pos": "381", "end_pos": "381" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N124-1.2197.2197", "start_pos": 2197, "end_pos": 2197, "uniprot_canonical_ac": "A0A8C2N124-1", "length": 2372, "uniprot_id": "A0A8C2N124_CRIGR", "protein_name": "Protein transport protein sec16", "refseq_ac": "XP_007649633", "refseq_name": "protein transport protein Sec16A isoform X1", "gene_name": "Sec16a", "gene_names_uniprotkb": "Sec16a", "gene_names_refseq": "Sec16a", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N124", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N124" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "APPPPPTSFPRVPQAAPTGP", "down_seq": "GPPTTSVNMFSRKAGGSRAR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2197", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "2197", "end_pos": "2197" }, { "start_pos": "2335", "end_pos": "2335" }, { "start_pos": "617", "end_pos": "617" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N124-1.2335.2335", "start_pos": 2335, "end_pos": 2335, "uniprot_canonical_ac": "A0A8C2N124-1", "length": 2372, "uniprot_id": "A0A8C2N124_CRIGR", "protein_name": "Protein transport protein sec16", "refseq_ac": "XP_007649633", "refseq_name": "protein transport protein Sec16A isoform X1", "gene_name": "Sec16a", "gene_names_uniprotkb": "Sec16a", "gene_names_refseq": "Sec16a", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N124", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N124" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SQEVSRHFHQAPGDHCPAGA", "down_seq": "PGGSVPFYNPAQLVQASVTS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2335", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "2197", "end_pos": "2197" }, { "start_pos": "2335", "end_pos": "2335" }, { "start_pos": "617", "end_pos": "617" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N124-1.617.617", "start_pos": 617, "end_pos": 617, "uniprot_canonical_ac": "A0A8C2N124-1", "length": 2372, "uniprot_id": "A0A8C2N124_CRIGR", "protein_name": "Protein transport protein sec16", "refseq_ac": "XP_007649633", "refseq_name": "protein transport protein Sec16A isoform X1", "gene_name": "Sec16a", "gene_names_uniprotkb": "Sec16a", "gene_names_refseq": "Sec16a", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N124", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N124" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GETDEVTGSQNYCSSLSQPS", "down_seq": "PSPPKPTGVFQTSANSSFEP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr617", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "2197", "end_pos": "2197" }, { "start_pos": "2335", "end_pos": "2335" }, { "start_pos": "617", "end_pos": "617" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N1B1-1.150.150", "start_pos": 150, "end_pos": 150, "uniprot_canonical_ac": "A0A8C2N1B1-1", "length": 658, "uniprot_id": "A0A8C2N1B1_CRIGR", "protein_name": "CXXC-type zinc finger protein 1", "refseq_ac": "XP_027253692", "refseq_name": "CXXC-type zinc finger protein 1 isoform X2", "gene_name": "Cxxc1", "gene_names_uniprotkb": "Cxxc1", "gene_names_refseq": "Cxxc1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N1B1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N1B1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TMLARGSASPHKSSPQPLVA", "down_seq": "PSQHHQQQQQQQQIKRSARM", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr150", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "150", "end_pos": "150" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N1L1-1.447.447", "start_pos": 447, "end_pos": 447, "uniprot_canonical_ac": "A0A8C2N1L1-1", "length": 644, "uniprot_id": "A0A8C2N1L1_CRIGR", "protein_name": "TNFAIP3-interacting protein 1", "refseq_ac": "XP_027283269", "refseq_name": "TNFAIP3-interacting protein 1 isoform X3", "gene_name": "Tnip1", "gene_names_uniprotkb": "Tnip1", "gene_names_refseq": "Tnip1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N1L1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N1L1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QRLNKALEDALSIQASPSSP", "down_seq": "PAFGSPEGAGSHLRKQELVT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr447", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "447", "end_pos": "447" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N1P2-1.533.533", "start_pos": 533, "end_pos": 533, "uniprot_canonical_ac": "A0A8C2N1P2-1", "length": 536, "uniprot_id": "A0A8C2N1P2_CRIGR", "protein_name": "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial", "refseq_ac": "XP_003505196", "refseq_name": "methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial", "gene_name": "Aldh6a1", "gene_names_uniprotkb": "Aldh6a1", "gene_names_refseq": "Aldh6a1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N1P2", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N1P2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ITSQWKEEDATLSSPAVVMP", "down_seq": "MGR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr533", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "533", "end_pos": "533" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N292-1.232.232", "start_pos": 232, "end_pos": 232, "uniprot_canonical_ac": "A0A8C2N292-1", "length": 723, "uniprot_id": "A0A8C2N292_CRIGR", "protein_name": "Threonine--tRNA ligase, mitochondrial", "refseq_ac": "XP_003498691", "refseq_name": "threonine--tRNA ligase, mitochondrial isoform X1", "gene_name": "Tars2", "gene_names_uniprotkb": "Tars2", "gene_names_refseq": "Tars2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N292", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N292" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QLFKDNHFKLHVIEEKVTGP", "down_seq": "ATVYGCGMSVDLCRGPHLRH", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr232", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "232", "end_pos": "232" }, { "start_pos": "32", "end_pos": "32" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N292-1.32.32", "start_pos": 32, "end_pos": 32, "uniprot_canonical_ac": "A0A8C2N292-1", "length": 723, "uniprot_id": "A0A8C2N292_CRIGR", "protein_name": "Threonine--tRNA ligase, mitochondrial", "refseq_ac": "XP_003498691", "refseq_name": "threonine--tRNA ligase, mitochondrial isoform X1", "gene_name": "Tars2", "gene_names_uniprotkb": "Tars2", "gene_names_refseq": "Tars2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N292", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N292" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LPLPGFRRCELHTVHEASVP", "down_seq": "PPHWLAERLGLFEELWTAQV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr32", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "232", "end_pos": "232" }, { "start_pos": "32", "end_pos": "32" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N2R1-1.109.109", "start_pos": 109, "end_pos": 109, "uniprot_canonical_ac": "A0A8C2N2R1-1", "length": 470, "uniprot_id": "A0A8C2N2R1_CRIGR", "protein_name": "Meiosis-specific with OB domain-containing protein", "refseq_ac": "XP_003501544", "refseq_name": "meiosis-specific with OB domain-containing protein", "gene_name": "Meiob", "gene_names_uniprotkb": "Meiob", "gene_names_refseq": "Meiob", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N2R1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N2R1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "IENPLIQRKETEREEKFSPA", "down_seq": "PSNWKLLLSENHSMVKVCSP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr109", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "109", "end_pos": "109" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N2X3-1.238.238", "start_pos": 238, "end_pos": 238, "uniprot_canonical_ac": "A0A8C2N2X3-1", "length": 1103, "uniprot_id": "A0A8C2N2X3_CRIGR", "protein_name": "Voltage-gated delayed rectifier potassium channel KCNH8", "refseq_ac": "XP_003500508", "refseq_name": "potassium voltage-gated channel subfamily H member 8", "gene_name": "Kcnh8", "gene_names_uniprotkb": "Kcnh8", "gene_names_refseq": "Kcnh8", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N2X3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N2X3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "STFKAGWDWLILLATFYVAV", "down_seq": "VPYNVCFIGNEDLSTTRSTT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr238", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "238", "end_pos": "238" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N3A5-1.805.805", "start_pos": 805, "end_pos": 805, "uniprot_canonical_ac": "A0A8C2N3A5-1", "length": 887, "uniprot_id": "A0A8C2N3A5_CRIGR", "protein_name": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform X2", "refseq_ac": "XP_027257219", "refseq_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform X2", "gene_name": "Hcn1", "gene_names_uniprotkb": "Hcn1", "gene_names_refseq": "Hcn1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N3A5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N3A5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SASQPSLPHEVSTIISRPHP", "down_seq": "VGESLASIPQPVAAVHSTGL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr805", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "805", "end_pos": "805" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N3B0-1.258.258", "start_pos": 258, "end_pos": 258, "uniprot_canonical_ac": "A0A8C2N3B0-1", "length": 295, "uniprot_id": "A0A8C2N3B0_CRIGR", "protein_name": "2-acylglycerol O-acyltransferase 1", "refseq_ac": "XP_027240256", "refseq_name": "2-acylglycerol O-acyltransferase 1 isoform X1", "gene_name": "Mogat1", "gene_names_uniprotkb": "Mogat1", "gene_names_refseq": "Mogat1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N3B0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N3B0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RKPIHAIVGRPIPVQRTPNP", "down_seq": "PEQTEQLHQTYMEELRKLFD", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr258", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "258", "end_pos": "258" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N3D1-1.116.116", "start_pos": 116, "end_pos": 116, "uniprot_canonical_ac": "A0A8C2N3D1-1", "length": 445, "uniprot_id": "A0A8C2N3D1_CRIGR", "protein_name": "Homeobox protein Hox-A3 isoform X2", "refseq_ac": "XP_027285428", "refseq_name": "homeobox protein Hox-A3 isoform X2", "gene_name": "Hoxa3", "gene_names_uniprotkb": "Hoxa3", "gene_names_refseq": "Hoxa3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N3D1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N3D1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PQAAPPAPQPPQPPPQPPAP", "down_seq": "PAAPPPPSSVSPPQSASSNP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr116", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "116", "end_pos": "116" }, { "start_pos": "341", "end_pos": "341" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N3D1-1.341.341", "start_pos": 341, "end_pos": 341, "uniprot_canonical_ac": "A0A8C2N3D1-1", "length": 445, "uniprot_id": "A0A8C2N3D1_CRIGR", "protein_name": "Homeobox protein Hox-A3 isoform X2", "refseq_ac": "XP_027285428", "refseq_name": "homeobox protein Hox-A3 isoform X2", "gene_name": "Hoxa3", "gene_names_uniprotkb": "Hoxa3", "gene_names_refseq": "Hoxa3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N3D1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N3D1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "APPPPPQKRYAAAAGSGAGG", "down_seq": "PDYDPHAHSLQGNGSYGTPH", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr341", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "116", "end_pos": "116" }, { "start_pos": "341", "end_pos": "341" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N3N3-1.178.178", "start_pos": 178, "end_pos": 178, "uniprot_canonical_ac": "A0A8C2N3N3-1", "length": 325, "uniprot_id": "A0A8C2N3N3_CRIGR", "protein_name": "Homeobox protein orthopedia", "refseq_ac": "XP_027257035", "refseq_name": "homeobox protein orthopedia isoform X2", "gene_name": "Otp", "gene_names_uniprotkb": "Otp", "gene_names_refseq": "Otp", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N3N3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N3N3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "KWKKRKKTTNVFRAPGTLLP", "down_seq": "PGLPQFPSAAAAAAAAMGDS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr178", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "178", "end_pos": "178" }, { "start_pos": "69", "end_pos": "69" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N3N3-1.69.69", "start_pos": 69, "end_pos": 69, "uniprot_canonical_ac": "A0A8C2N3N3-1", "length": 325, "uniprot_id": "A0A8C2N3N3_CRIGR", "protein_name": "Homeobox protein orthopedia", "refseq_ac": "XP_027257035", "refseq_name": "homeobox protein orthopedia isoform X2", "gene_name": "Otp", "gene_names_uniprotkb": "Otp", "gene_names_refseq": "Otp", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N3N3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N3N3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SDPVEGATLLPGEDITTVGS", "down_seq": "PASLAVSAKDPDKQPGPQGG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr69", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "178", "end_pos": "178" }, { "start_pos": "69", "end_pos": "69" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N568-1.160.160", "start_pos": 160, "end_pos": 160, "uniprot_canonical_ac": "A0A8C2N568-1", "length": 2112, "uniprot_id": "A0A8C2N568_CRIGR", "protein_name": "Coagulation factor V", "refseq_ac": "XP_003508322", "refseq_name": "coagulation factor V", "gene_name": "F5", "gene_names_uniprotkb": "F5", "gene_names_refseq": "F5", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N568", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N568" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AVAPGGEYTYEWVISEDSGP", "down_seq": "PDDPPCLTHIYYSYENLTQD", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr160", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "160", "end_pos": "160" }, { "start_pos": "463", "end_pos": "463" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N568-1.463.463", "start_pos": 463, "end_pos": 463, "uniprot_canonical_ac": "A0A8C2N568-1", "length": 2112, "uniprot_id": "A0A8C2N568_CRIGR", "protein_name": "Coagulation factor V", "refseq_ac": "XP_003508322", "refseq_name": "coagulation factor V", "gene_name": "F5", "gene_names_uniprotkb": "F5", "gene_names_refseq": "F5", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N568", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N568" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SIYPHGVTFSPYEDEGNSSS", "down_seq": "PGSHTMIRPVQPGETYTYKW", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr463", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "160", "end_pos": "160" }, { "start_pos": "463", "end_pos": "463" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N5G8-1.550.550", "start_pos": 550, "end_pos": 550, "uniprot_canonical_ac": "A0A8C2N5G8-1", "length": 641, "uniprot_id": "A0A8C2N5G8_CRIGR", "protein_name": "E3 ubiquitin-protein ligase TRIM47", "refseq_ac": "XP_027281445", "refseq_name": "E3 ubiquitin-protein ligase TRIM47 isoform X2", "gene_name": "Trim47", "gene_names_uniprotkb": "Trim47", "gene_names_refseq": "Trim47", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N5G8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N5G8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RGFSVWFCGLEAPLPHAFSP", "down_seq": "VGVCLEYADHALAFYAVRDG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr550", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "550", "end_pos": "550" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N6I4-1.591.591", "start_pos": 591, "end_pos": 591, "uniprot_canonical_ac": "A0A8C2N6I4-1", "length": 1392, "uniprot_id": "A0A8C2N6I4_CRIGR", "protein_name": "Nuclear pore complex protein Nup155", "refseq_ac": "XP_003504041", "refseq_name": "nuclear pore complex protein Nup155", "gene_name": "Nup155", "gene_names_uniprotkb": "Nup155", "gene_names_refseq": "Nup155", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N6I4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N6I4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TRAFFRYGGEAQMRFPATLP", "down_seq": "PSNVGPILGSPMYSSSPVPS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr591", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "591", "end_pos": "591" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N705-1.621.621", "start_pos": 621, "end_pos": 621, "uniprot_canonical_ac": "A0A8C2N705-1", "length": 636, "uniprot_id": "A0A8C2N705_CRIGR", "protein_name": "Sodium-dependent phosphate transport protein 2A", "refseq_ac": "XP_035297434", "refseq_name": "sodium-dependent phosphate transport protein 2A", "gene_name": "Slc34a1", "gene_names_uniprotkb": "Slc34a1", "gene_names_refseq": "Slc34a1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N705", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N705" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PEPRSPQLPPRVFLEELPPA", "down_seq": "PSPRLALPTHNATRL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr621", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "621", "end_pos": "621" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N760-1.412.412", "start_pos": 412, "end_pos": 412, "uniprot_canonical_ac": "A0A8C2N760-1", "length": 452, "uniprot_id": "A0A8C2N760_CRIGR", "protein_name": "Growth/differentiation factor 6", "refseq_ac": "XP_027259293", "refseq_name": "growth/differentiation factor 6", "gene_name": "LOC113834414", "gene_names_uniprotkb": "LOC113834414", "gene_names_refseq": "LOC113834414", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N760", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N760" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LEPTNHAIIQTLMNSMDPGS", "down_seq": "PPSCCVPTKLTPISILYIDA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr412", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "412", "end_pos": "412" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N7Y8-1.769.769", "start_pos": 769, "end_pos": 769, "uniprot_canonical_ac": "A0A8C2N7Y8-1", "length": 1200, "uniprot_id": "A0A8C2N7Y8_CRIGR", "protein_name": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform X2", "refseq_ac": "XP_027270707", "refseq_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform X2", "gene_name": "Hcn4", "gene_names_uniprotkb": "Hcn4", "gene_names_refseq": "Hcn4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N7Y8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N7Y8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "HDREMAHCAHRVQAAASATP", "down_seq": "PTPVIWTPLIQAPLQAAAAT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr769", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "769", "end_pos": "769" }, { "start_pos": "771", "end_pos": "771" }, { "start_pos": "895", "end_pos": "895" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "upstream", "id": "A0A8C2N7Y8-1.771.771", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N7Y8-1.771.771", "start_pos": 771, "end_pos": 771, "uniprot_canonical_ac": "A0A8C2N7Y8-1", "length": 1200, "uniprot_id": "A0A8C2N7Y8_CRIGR", "protein_name": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform X2", "refseq_ac": "XP_027270707", "refseq_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform X2", "gene_name": "Hcn4", "gene_names_uniprotkb": "Hcn4", "gene_names_refseq": "Hcn4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N7Y8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N7Y8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "REMAHCAHRVQAAASATPTP", "down_seq": "PVIWTPLIQAPLQAAAATTS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr771", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "769", "end_pos": "769" }, { "start_pos": "771", "end_pos": "771" }, { "start_pos": "895", "end_pos": "895" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "downstream", "id": "A0A8C2N7Y8-1.769.769", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N7Y8-1.895.895", "start_pos": 895, "end_pos": 895, "uniprot_canonical_ac": "A0A8C2N7Y8-1", "length": 1200, "uniprot_id": "A0A8C2N7Y8_CRIGR", "protein_name": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform X2", "refseq_ac": "XP_027270707", "refseq_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform X2", "gene_name": "Hcn4", "gene_names_uniprotkb": "Hcn4", "gene_names_refseq": "Hcn4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N7Y8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N7Y8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LLPSSSSSPPPGACGSPPAP", "down_seq": "PSTSAAAATTAGFGHFHKAL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr895", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "769", "end_pos": "769" }, { "start_pos": "771", "end_pos": "771" }, { "start_pos": "895", "end_pos": "895" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N973-1.584.584", "start_pos": 584, "end_pos": 584, "uniprot_canonical_ac": "A0A8C2N973-1", "length": 796, "uniprot_id": "A0A8C2N973_CRIGR", "protein_name": "Zinc finger protein 148", "refseq_ac": "XP_007638945", "refseq_name": "zinc finger protein 148 isoform X1", "gene_name": "Znf148", "gene_names_uniprotkb": "Znf148", "gene_names_refseq": "Znf148", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N973", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N973" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VADTEVTSSISINSSDVPEV", "down_seq": "PSENVGSSSQASSADKANML", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr584", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "584", "end_pos": "584" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2NAC9-1.276.276", "start_pos": 276, "end_pos": 276, "uniprot_canonical_ac": "A0A8C2NAC9-1", "length": 570, "uniprot_id": "A0A8C2NAC9_CRIGR", "protein_name": "FERM domain-containing protein 5", "refseq_ac": "XP_027277808", "refseq_name": "FERM domain-containing protein 5 isoform X5", "gene_name": "Frmd5", "gene_names_uniprotkb": "Frmd5", "gene_names_refseq": "Frmd5", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2NAC9", "url": "https://www.uniprot.org/uniprotkb/A0A8C2NAC9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "FYLYVSQKEEKKIILTYFAP", "down_seq": "PEACKHLWKCGIENQAFYKL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr276", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "276", "end_pos": "276" }, { "start_pos": "433", "end_pos": "433" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2NAC9-1.433.433", "start_pos": 433, "end_pos": 433, "uniprot_canonical_ac": "A0A8C2NAC9-1", "length": 570, "uniprot_id": "A0A8C2NAC9_CRIGR", "protein_name": "FERM domain-containing protein 5", "refseq_ac": "XP_027277808", "refseq_name": "FERM domain-containing protein 5 isoform X5", "gene_name": "Frmd5", "gene_names_uniprotkb": "Frmd5", "gene_names_refseq": "Frmd5", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2NAC9", "url": "https://www.uniprot.org/uniprotkb/A0A8C2NAC9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "NERVAVIADEAYSPADSVLP", "down_seq": "PVAEHSLELMLLSRQINGAT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr433", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "276", "end_pos": "276" }, { "start_pos": "433", "end_pos": "433" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2NAT2-1.62.62", "start_pos": 62, "end_pos": 62, "uniprot_canonical_ac": "A0A8C2NAT2-1", "length": 169, "uniprot_id": "A0A8C2NAT2_CRIGR", "protein_name": "Diamine acetyltransferase 1", "refseq_ac": "XP_027281988", "refseq_name": "diamine acetyltransferase 2 isoform X2", "gene_name": "Sat2", "gene_names_uniprotkb": "Sat2", "gene_names_refseq": "Sat2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2NAT2", "url": "https://www.uniprot.org/uniprotkb/A0A8C2NAT2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RADGFGENPSFHCLVAEVIP", "down_seq": "PGELQGPRVVGFGLYYFIYS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr62", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "62", "end_pos": "62" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QCH1-1.1003.1003", "start_pos": 1003, "end_pos": 1003, "uniprot_canonical_ac": "A0A8C2QCH1-1", "length": 1503, "uniprot_id": "A0A8C2QCH1_CRIGR", "protein_name": "Rho GTPase-activating protein 5", "refseq_ac": "XP_003512723", "refseq_name": "rho GTPase-activating protein 5 isoform X1", "gene_name": "Arhgap5", "gene_names_uniprotkb": "Arhgap5", "gene_names_refseq": "Arhgap5", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QCH1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QCH1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DDTEAPPPYSPIGDDVQLLP", "down_seq": "PSDRSRYRLDLEGNEYPVHS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1003", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1003", "end_pos": "1003" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QDW1-1.488.488", "start_pos": 488, "end_pos": 488, "uniprot_canonical_ac": "A0A8C2QDW1-1", "length": 570, "uniprot_id": "A0A8C2QDW1_CRIGR", "protein_name": "Double-stranded RNA-binding protein Staufen homolog 2", "refseq_ac": "XP_035295894", "refseq_name": "double-stranded RNA-binding protein Staufen homolog 2 isoform X2", "gene_name": "Stau2", "gene_names_uniprotkb": "Stau2", "gene_names_refseq": "Stau2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QDW1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QDW1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LLMNGTSPTAEAIGLKGSSP", "down_seq": "PPCSPVQPSKQLEYLARIQG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr488", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "488", "end_pos": "488" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QDY9-1.623.623", "start_pos": 623, "end_pos": 623, "uniprot_canonical_ac": "A0A8C2QDY9-1", "length": 1338, "uniprot_id": "A0A8C2QDY9_CRIGR", "protein_name": "Phosphoribosylformylglycinamidine synthase", "refseq_ac": "XP_027282873", "refseq_name": "phosphoribosylformylglycinamidine synthase", "gene_name": "Pfas", "gene_names_uniprotkb": "Pfas", "gene_names_refseq": "Pfas", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QDY9", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QDY9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DRECPVGKSGQGDASLTPPP", "down_seq": "PVDLELDWVLGKMPQKEFFL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr623", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "623", "end_pos": "623" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QE76-1.77.77", "start_pos": 77, "end_pos": 77, "uniprot_canonical_ac": "A0A8C2QE76-1", "length": 269, "uniprot_id": "A0A8C2QE76_CRIGR", "protein_name": "Voltage-gated hydrogen channel 1", "refseq_ac": "XP_007625985", "refseq_name": "voltage-gated hydrogen channel 1", "gene_name": "Hvcn1", "gene_names_uniprotkb": "Hvcn1", "gene_names_refseq": "Hvcn1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QE76", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QE76" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TSAEGEGSAVGTDAEAGPVP", "down_seq": "PKPALDFRNRLRKLFSSHRF", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr77", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "77", "end_pos": "77" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QEK1-1.234.234", "start_pos": 234, "end_pos": 234, "uniprot_canonical_ac": "A0A8C2QEK1-1", "length": 319, "uniprot_id": "A0A8C2QEK1_CRIGR", "protein_name": "Transcription factor SOX-2 isoform X2", "refseq_ac": "XP_027247795", "refseq_name": "transcription factor SOX-2 isoform X2", "gene_name": "Sox2", "gene_names_uniprotkb": "Sox2", "gene_names_refseq": "Sox2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QEK1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QEK1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SSQTYMNGSPTYSMSYSQQG", "down_seq": "PGMALGSMGSVVKSEASSSP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr234", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "234", "end_pos": "234" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QEP6-1.1885.1885", "start_pos": 1885, "end_pos": 1885, "uniprot_canonical_ac": "A0A8C2QEP6-1", "length": 4350, "uniprot_id": "A0A8C2QEP6_CRIGR", "protein_name": "Protocadherin Fat 2", "refseq_ac": "XP_027283256", "refseq_name": "protocadherin Fat 2 isoform X2", "gene_name": "Fat2", "gene_names_uniprotkb": "Fat2", "gene_names_refseq": "Fat2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QEP6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QEP6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VNDFSPRFSEQIYEVAVVGP", "down_seq": "HPGMKLLTVQAKDDDSEVIY", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1885", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1885", "end_pos": "1885" }, { "start_pos": "199", "end_pos": "199" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QEP6-1.199.199", "start_pos": 199, "end_pos": 199, "uniprot_canonical_ac": "A0A8C2QEP6-1", "length": 4350, "uniprot_id": "A0A8C2QEP6_CRIGR", "protein_name": "Protocadherin Fat 2", "refseq_ac": "XP_027283256", "refseq_name": "protocadherin Fat 2 isoform X2", "gene_name": "Fat2", "gene_names_uniprotkb": "Fat2", "gene_names_refseq": "Fat2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QEP6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QEP6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QNSEFYYAFNARSEVFAIHP", "down_seq": "SGVVTVARKLNVTWRGKYEL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr199", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1885", "end_pos": "1885" }, { "start_pos": "199", "end_pos": "199" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QF95-1.555.555", "start_pos": 555, "end_pos": 555, "uniprot_canonical_ac": "A0A8C2QF95-1", "length": 778, "uniprot_id": "A0A8C2QF95_CRIGR", "protein_name": "Vacuolar protein sorting-associated protein 51 homolog", "refseq_ac": "XP_027264332", "refseq_name": "vacuolar protein sorting-associated protein 51 homolog isoform X2", "gene_name": "Vps51", "gene_names_uniprotkb": "Vps51", "gene_names_refseq": "Vps51", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QF95", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QF95" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ISYILTLTDEQFLVQDQSPV", "down_seq": "PVSTLCAEARETARRLLTHY", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr555", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "555", "end_pos": "555" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QFK6-1.240.240", "start_pos": 240, "end_pos": 240, "uniprot_canonical_ac": "A0A8C2QFK6-1", "length": 859, "uniprot_id": "A0A8C2QFK6_CRIGR", "protein_name": "Spindle and centriole-associated protein 1", "refseq_ac": "XP_003497906", "refseq_name": "spindle and centriole-associated protein 1 isoform X1", "gene_name": "Spice1", "gene_names_uniprotkb": "Spice1", "gene_names_refseq": "Spice1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QFK6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QFK6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QLWTDIQQKIATQSQRTPPG", "down_seq": "PSSLLSAEEQKAALNATDAV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr240", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "240", "end_pos": "240" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QG51-1.789.789", "start_pos": 789, "end_pos": 789, "uniprot_canonical_ac": "A0A8C2QG51-1", "length": 1485, "uniprot_id": "A0A8C2QG51_CRIGR", "protein_name": "GTPase-activating protein and VPS9 domain-containing protein 1", "refseq_ac": "XP_016835642", "refseq_name": "GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1", "gene_name": "Gapvd1", "gene_names_uniprotkb": "Gapvd1", "gene_names_refseq": "Gapvd1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QG51", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QG51" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SGLGSTSDDTDVREVSSRPS", "down_seq": "PGLSVVSGISATSEDIPNKI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr789", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QG68-1.921.921", "start_pos": 921, "end_pos": 921, "uniprot_canonical_ac": "A0A8C2QG68-1", "length": 935, "uniprot_id": "A0A8C2QG68_CRIGR", "protein_name": "Phosphodiesterase", "refseq_ac": "XP_027275929", "refseq_name": "dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X3", "gene_name": "LOC100756511", "gene_names_uniprotkb": "LOC100756511", "gene_names_refseq": "LOC100756511", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QG68", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QG68" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "NRRKWEELHHKRLQVSAASP", "down_seq": "PTPSSLMAAGGDRL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr921", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "921", "end_pos": "921" }, { "start_pos": "923", "end_pos": "923" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "upstream", "id": "A0A8C2QG68-1.923.923", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QG68-1.923.923", "start_pos": 923, "end_pos": 923, "uniprot_canonical_ac": "A0A8C2QG68-1", "length": 935, "uniprot_id": "A0A8C2QG68_CRIGR", "protein_name": "Phosphodiesterase", "refseq_ac": "XP_027275929", "refseq_name": "dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X3", "gene_name": "LOC100756511", "gene_names_uniprotkb": "LOC100756511", "gene_names_refseq": "LOC100756511", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QG68", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QG68" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RKWEELHHKRLQVSAASPTP", "down_seq": "PSSLMAAGGDRL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr923", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "921", "end_pos": "921" }, { "start_pos": "923", "end_pos": "923" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "downstream", "id": "A0A8C2QG68-1.921.921", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QGP9-1.87.87", "start_pos": 87, "end_pos": 87, "uniprot_canonical_ac": "A0A8C2QGP9-1", "length": 401, "uniprot_id": "A0A8C2QGP9_CRIGR", "protein_name": "cAMP-dependent protein kinase type II-alpha regulatory subunit", "refseq_ac": "XP_007642954", "refseq_name": "cAMP-dependent protein kinase type II-alpha regulatory subunit isoform X2", "gene_name": "Prkar2a", "gene_names_uniprotkb": "Prkar2a", "gene_names_refseq": "Prkar2a", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QGP9", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QGP9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ATEEDKESDSDSDDGDLEVP", "down_seq": "PGRFSRRVSVCAESYNPDEE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr87", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "87", "end_pos": "87" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QGY5-1.635.635", "start_pos": 635, "end_pos": 635, "uniprot_canonical_ac": "A0A8C2QGY5-1", "length": 1306, "uniprot_id": "A0A8C2QGY5_CRIGR", "protein_name": "non-specific serine/threonine protein kinase", "refseq_ac": "XP_003508377", "refseq_name": "tau-tubulin kinase 1", "gene_name": "Ttbk1", "gene_names_uniprotkb": "Ttbk1", "gene_names_refseq": "Ttbk1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QGY5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QGY5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QPAPPQLSQADGRSETSQPP", "down_seq": "PGSLSHSPLHSGPRPRRRES", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr635", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "635", "end_pos": "635" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QH88-1.313.313", "start_pos": 313, "end_pos": 313, "uniprot_canonical_ac": "A0A8C2QH88-1", "length": 339, "uniprot_id": "A0A8C2QH88_CRIGR", "protein_name": "Dual specificity protein phosphatase 12", "refseq_ac": "XP_027272857", "refseq_name": "dual specificity protein phosphatase 12 isoform X3", "gene_name": "Dusp12", "gene_names_uniprotkb": "Dusp12", "gene_names_refseq": "Dusp12", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QH88", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QH88" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SAKLGSFNWYGEQCSCGRWI", "down_seq": "PAFQIHKNRVDEMKMLPALG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr313", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "313", "end_pos": "313" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QJB0-1.1282.1282", "start_pos": 1282, "end_pos": 1282, "uniprot_canonical_ac": "A0A8C2QJB0-1", "length": 1761, "uniprot_id": "A0A8C2QJB0_CRIGR", "protein_name": "Lysine-specific demethylase", "refseq_ac": "XP_027256535", "refseq_name": "lysine-specific demethylase 3B isoform X2", "gene_name": "Kdm3b", "gene_names_uniprotkb": "Kdm3b", "gene_names_refseq": "Kdm3b", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QJB0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QJB0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "STAKVSPLTPKLFNSLLLGP", "down_seq": "ASNSKTEGSSLRDLLHSGPG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1282", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1282", "end_pos": "1282" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QJZ1-1.884.884", "start_pos": 884, "end_pos": 884, "uniprot_canonical_ac": "A0A8C2QJZ1-1", "length": 1925, "uniprot_id": "A0A8C2QJZ1_CRIGR", "protein_name": "NFX1-type zinc finger-containing protein 1", "refseq_ac": "XP_003502518", "refseq_name": "NFX1-type zinc finger-containing protein 1 isoform X1", "gene_name": "Znfx1", "gene_names_uniprotkb": "Znfx1", "gene_names_refseq": "Znfx1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QJZ1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QJZ1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VDQELAKMLLAMRLDQPGPV", "down_seq": "PAGQEQTTEEWETQRNQKKR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr884", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "884", "end_pos": "884" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QK16-1.175.175", "start_pos": 175, "end_pos": 175, "uniprot_canonical_ac": "A0A8C2QK16-1", "length": 449, "uniprot_id": "A0A8C2QK16_CRIGR", "protein_name": "Krueppel-like factor 5 isoform X2", "refseq_ac": "XP_027249804", "refseq_name": "Krueppel-like factor 5 isoform X2", "gene_name": "Klf5", "gene_names_uniprotkb": "Klf5", "gene_names_refseq": "Klf5", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QK16", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QK16" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TEPVAIFSHQSETTAPPPAP", "down_seq": "QALPEFNSIFSSHQNTAPEV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr175", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "175", "end_pos": "175" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QK77-1.790.790", "start_pos": 790, "end_pos": 790, "uniprot_canonical_ac": "A0A8C2QK77-1", "length": 1457, "uniprot_id": "A0A8C2QK77_CRIGR", "protein_name": "Macrophage mannose receptor 1", "refseq_ac": "XP_007642176", "refseq_name": "macrophage mannose receptor 1 isoform X2", "gene_name": "Mrc1", "gene_names_uniprotkb": "Mrc1", "gene_names_refseq": "Mrc1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QK77", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QK77" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EHLSNWICQIQKGKTLLPEP", "down_seq": "PAPQDNPPVTADGWVIYKDH", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr790", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "790", "end_pos": "790" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QKT5-1.456.456", "start_pos": 456, "end_pos": 456, "uniprot_canonical_ac": "A0A8C2QKT5-1", "length": 544, "uniprot_id": "A0A8C2QKT5_CRIGR", "protein_name": "RING-type E3 ubiquitin transferase", "refseq_ac": "XP_027254679", "refseq_name": "tripartite motif-containing protein 55", "gene_name": "Trim55", "gene_names_uniprotkb": "Trim55", "gene_names_refseq": "Trim55", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QKT5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QKT5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LFYPSWYKGQNRKTISNPPC", "down_seq": "PGSEGLGQIGPPGAEDSSVQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr456", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "456", "end_pos": "456" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QL15-1.89.89", "start_pos": 89, "end_pos": 89, "uniprot_canonical_ac": "A0A8C2QL15-1", "length": 849, "uniprot_id": "A0A8C2QL15_CRIGR", "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 4", "refseq_ac": "XP_007645592", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 4", "gene_name": "Adamts4", "gene_names_uniprotkb": "Adamts4", "gene_names_refseq": "Adamts4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QL15", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QL15" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "REEEIVFPEKLNGSILPGSG", "down_seq": "PARMLYRLPAFGEVLLLELE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr89", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "89", "end_pos": "89" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QL35-1.528.528", "start_pos": 528, "end_pos": 528, "uniprot_canonical_ac": "A0A8C2QL35-1", "length": 562, "uniprot_id": "A0A8C2QL35_CRIGR", "protein_name": "Anthrax toxin receptor", "refseq_ac": "XP_027284535", "refseq_name": "anthrax toxin receptor 1 isoform X2", "gene_name": "Antxr1", "gene_names_uniprotkb": "Antxr1", "gene_names_refseq": "Antxr1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QL35", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QL35" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PIYTPPPPASHCPPPAPSAP", "down_seq": "PPIPSPPSTLPPPPQAPPPN", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr528", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "528", "end_pos": "528" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QL53-1.249.249", "start_pos": 249, "end_pos": 249, "uniprot_canonical_ac": "A0A8C2QL53-1", "length": 1016, "uniprot_id": "A0A8C2QL53_CRIGR", "protein_name": "Protein HIRA", "refseq_ac": "XP_027268903", "refseq_name": "protein HIRA isoform X4", "gene_name": "LOC100769195", "gene_names_uniprotkb": "LOC100769195", "gene_names_refseq": "LOC100769195", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QL53", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QL53" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SWSPDGHYLVSAHAMNNSGP", "down_seq": "AQIIEREGWKTNMDFVGHRK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr249", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "249", "end_pos": "249" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QL63-1.1282.1282", "start_pos": 1282, "end_pos": 1282, "uniprot_canonical_ac": "A0A8C2QL63-1", "length": 1289, "uniprot_id": "A0A8C2QL63_CRIGR", "protein_name": "mitogen-activated protein kinase kinase kinase", "refseq_ac": "XP_027255359", "refseq_name": "mitogen-activated protein kinase kinase kinase 6 isoform X2", "gene_name": "Map3k6", "gene_names_uniprotkb": "Map3k6", "gene_names_refseq": "Map3k6", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QL63", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QL63" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GMVCRIWRAILAQRARATPV", "down_seq": "PGPREAE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1282", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1282", "end_pos": "1282" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QLN6-1.357.357", "start_pos": 357, "end_pos": 357, "uniprot_canonical_ac": "A0A8C2QLN6-1", "length": 572, "uniprot_id": "A0A8C2QLN6_CRIGR", "protein_name": "Transmembrane protein 108 isoform X2", "refseq_ac": "XP_027270142", "refseq_name": "transmembrane protein 108 isoform X2", "gene_name": "Tmem108", "gene_names_uniprotkb": "Tmem108", "gene_names_refseq": "Tmem108", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QLN6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QLN6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PDTDRPLSASSRVFTAATGP", "down_seq": "QAAFDTSVSVPSQGIPQGTS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr357", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "357", "end_pos": "357" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QLX7-1.10.10", "start_pos": 10, "end_pos": 10, "uniprot_canonical_ac": "A0A8C2QLX7-1", "length": 424, "uniprot_id": "A0A8C2QLX7_CRIGR", "protein_name": "Vasopressin V1b receptor", "refseq_ac": "XP_003501261", "refseq_name": "vasopressin V1b receptor", "gene_name": "Avpr1b", "gene_names_uniprotkb": "Avpr1b", "gene_names_refseq": "Avpr1b", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QLX7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QLX7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MDSEPSWTA", "down_seq": "PSPGGTQSVPNATTPWLGRD", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr10", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "10", "end_pos": "10" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QM57-1.293.293", "start_pos": 293, "end_pos": 293, "uniprot_canonical_ac": "A0A8C2QM57-1", "length": 324, "uniprot_id": "A0A8C2QM57_CRIGR", "protein_name": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase", "refseq_ac": "XP_027248610", "refseq_name": "galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 isoform X2", "gene_name": "B3gat2", "gene_names_uniprotkb": "B3gat2", "gene_names_refseq": "B3gat2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QM57", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QM57" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A8C2QM57", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QM57", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR605027-6", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR605027-6", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "QESDFLKQITTVEELEPKAN", "down_seq": "CTKVLVWHTRTEKVNLANEP", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn293", "evidence": [ { "id": "A0A8C2QM57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QM57#ptm_processing" }, { "id": "PIRSR605027-6", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR605027-6" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "293", "end_pos": "293" }, { "start_pos": "87", "end_pos": "87" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QM57-1.87.87", "start_pos": 87, "end_pos": 87, "uniprot_canonical_ac": "A0A8C2QM57-1", "length": 324, "uniprot_id": "A0A8C2QM57_CRIGR", "protein_name": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase", "refseq_ac": "XP_027248610", "refseq_name": "galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 isoform X2", "gene_name": "B3gat2", "gene_names_uniprotkb": "B3gat2", "gene_names_refseq": "B3gat2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QM57", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QM57" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RNESRPRLQPEPRLPTIYAI", "down_seq": "PTYSRPVQKAELTRLANTFR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr87", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "293", "end_pos": "293" }, { "start_pos": "87", "end_pos": "87" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QMF2-1.487.487", "start_pos": 487, "end_pos": 487, "uniprot_canonical_ac": "A0A8C2QMF2-1", "length": 683, "uniprot_id": "A0A8C2QMF2_CRIGR", "protein_name": "T-box brain protein 1 isoform X2", "refseq_ac": "XP_027276126", "refseq_name": "T-box brain protein 1 isoform X2", "gene_name": "Tbr1", "gene_names_uniprotkb": "Tbr1", "gene_names_refseq": "Tbr1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QMF2", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QMF2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LLSPQQAEDPGAPSPQRWFV", "down_seq": "PANNRLDFAASAYDTATDFA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr487", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "487", "end_pos": "487" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QML7-1.44.44", "start_pos": 44, "end_pos": 44, "uniprot_canonical_ac": "A0A8C2QML7-1", "length": 719, "uniprot_id": "A0A8C2QML7_CRIGR", "protein_name": "Forkhead box protein K1", "refseq_ac": "XP_027269340", "refseq_name": "forkhead box protein K1 isoform X2", "gene_name": "Foxk1", "gene_names_uniprotkb": "Foxk1", "gene_names_refseq": "Foxk1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QML7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QML7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VLCAAAAAAAFPATASPPPP", "down_seq": "QPPPGPPALPAVPGPGPVPS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr44", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "44", "end_pos": "44" }, { "start_pos": "671", "end_pos": "671" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QML7-1.671.671", "start_pos": 671, "end_pos": 671, "uniprot_canonical_ac": "A0A8C2QML7-1", "length": 719, "uniprot_id": "A0A8C2QML7_CRIGR", "protein_name": "Forkhead box protein K1", "refseq_ac": "XP_027269340", "refseq_name": "forkhead box protein K1 isoform X2", "gene_name": "Foxk1", "gene_names_uniprotkb": "Foxk1", "gene_names_refseq": "Foxk1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QML7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QML7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "CEVGPEESTAAVSVATNATP", "down_seq": "PATSTTTSASSSGEPEIKRS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr671", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "44", "end_pos": "44" }, { "start_pos": "671", "end_pos": "671" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QMN7-1.19.19", "start_pos": 19, "end_pos": 19, "uniprot_canonical_ac": "A0A8C2QMN7-1", "length": 771, "uniprot_id": "A0A8C2QMN7_CRIGR", "protein_name": "Transcription factor SOX-30", "refseq_ac": "XP_027280646", "refseq_name": "LOW QUALITY PROTEIN: transcription factor SOX-30 isoform X2", "gene_name": "Sox30", "gene_names_uniprotkb": "Sox30", "gene_names_refseq": "Sox30", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QMN7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QMN7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MERARPEPPPPPRQPPRP", "down_seq": "PPRPLRPAPPAQSVEAATFR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr19", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "19", "end_pos": "19" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QMS6-1.149.149", "start_pos": 149, "end_pos": 149, "uniprot_canonical_ac": "A0A8C2QMS6-1", "length": 590, "uniprot_id": "A0A8C2QMS6_CRIGR", "protein_name": "Max-binding protein MNT", "refseq_ac": "XP_027282576", "refseq_name": "max-binding protein MNT isoform X2", "gene_name": "Mnt", "gene_names_uniprotkb": "Mnt", "gene_names_refseq": "Mnt", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QMS6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QMS6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PGLSIKEPVPLPTRPQVPTP", "down_seq": "PLLPDTKTTAAPTGSPKPLQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr149", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "84", "end_pos": "84" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QMS6-1.173.173", "start_pos": 173, "end_pos": 173, "uniprot_canonical_ac": "A0A8C2QMS6-1", "length": 590, "uniprot_id": "A0A8C2QMS6_CRIGR", "protein_name": "Max-binding protein MNT", "refseq_ac": "XP_027282576", "refseq_name": "max-binding protein MNT isoform X2", "gene_name": "Mnt", "gene_names_uniprotkb": "Mnt", "gene_names_refseq": "Mnt", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QMS6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QMS6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PDTKTTAAPTGSPKPLQPLP", "down_seq": "PILTIAPHPGVQPQLAPQQP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr173", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "84", "end_pos": "84" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QMS6-1.420.420", "start_pos": 420, "end_pos": 420, "uniprot_canonical_ac": "A0A8C2QMS6-1", "length": 590, "uniprot_id": "A0A8C2QMS6_CRIGR", "protein_name": "Max-binding protein MNT", "refseq_ac": "XP_027282576", "refseq_name": "max-binding protein MNT isoform X2", "gene_name": "Mnt", "gene_names_uniprotkb": "Mnt", "gene_names_refseq": "Mnt", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QMS6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QMS6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VQQPPPQQKTPLPAPPPPPA", "down_seq": "PTQTLVPAPAHLVATAGGGS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr420", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "84", "end_pos": "84" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QMS6-1.84.84", "start_pos": 84, "end_pos": 84, "uniprot_canonical_ac": "A0A8C2QMS6-1", "length": 590, "uniprot_id": "A0A8C2QMS6_CRIGR", "protein_name": "Max-binding protein MNT", "refseq_ac": "XP_027282576", "refseq_name": "max-binding protein MNT isoform X2", "gene_name": "Mnt", "gene_names_uniprotkb": "Mnt", "gene_names_refseq": "Mnt", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QMS6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QMS6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "APALPLSPPAPPPAPPPPLA", "down_seq": "PTPLTVIPIPVVTNSPQSLP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr84", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "84", "end_pos": "84" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QMT2-1.232.232", "start_pos": 232, "end_pos": 232, "uniprot_canonical_ac": "A0A8C2QMT2-1", "length": 245, "uniprot_id": "A0A8C2QMT2_CRIGR", "protein_name": "Fibroblast growth factor", "refseq_ac": "XP_027265000", "refseq_name": "fibroblast growth factor 3 isoform X2", "gene_name": "Fgf3", "gene_names_uniprotkb": "Fgf3", "gene_names_refseq": "Fgf3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QMT2", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QMT2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RQKKQSPGDHGRMEPLSPRA", "down_seq": "PGTHLETGELAVA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr232", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "232", "end_pos": "232" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QMV3-1.243.243", "start_pos": 243, "end_pos": 243, "uniprot_canonical_ac": "A0A8C2QMV3-1", "length": 342, "uniprot_id": "A0A8C2QMV3_CRIGR", "protein_name": "Polycomb group RING finger protein 2", "refseq_ac": "XP_003499621", "refseq_name": "polycomb group RING finger protein 2", "gene_name": "Pcgf2", "gene_names_uniprotkb": "Pcgf2", "gene_names_refseq": "Pcgf2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QMV3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QMV3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LPLKYRVQPACKRLTLPTVP", "down_seq": "PSEGTNTSGASECESVSDKA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr243", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "243", "end_pos": "243" }, { "start_pos": "281", "end_pos": "281" }, { "start_pos": "301", "end_pos": "301" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QMV3-1.281.281", "start_pos": 281, "end_pos": 281, "uniprot_canonical_ac": "A0A8C2QMV3-1", "length": 342, "uniprot_id": "A0A8C2QMV3_CRIGR", "protein_name": "Polycomb group RING finger protein 2", "refseq_ac": "XP_003499621", "refseq_name": "polycomb group RING finger protein 2", "gene_name": "Pcgf2", "gene_names_uniprotkb": "Pcgf2", "gene_names_refseq": "Pcgf2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QMV3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QMV3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DKAPSPATLPATSSSLPSPA", "down_seq": "PSHGSPISHGPPAIHPTSPT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr281", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "243", "end_pos": "243" }, { "start_pos": "281", "end_pos": "281" }, { "start_pos": "301", "end_pos": "301" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 20, "direction": "upstream", "id": "A0A8C2QMV3-1.301.301", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QMV3-1.301.301", "start_pos": 301, "end_pos": 301, "uniprot_canonical_ac": "A0A8C2QMV3-1", "length": 342, "uniprot_id": "A0A8C2QMV3_CRIGR", "protein_name": "Polycomb group RING finger protein 2", "refseq_ac": "XP_003499621", "refseq_name": "polycomb group RING finger protein 2", "gene_name": "Pcgf2", "gene_names_uniprotkb": "Pcgf2", "gene_names_refseq": "Pcgf2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QMV3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QMV3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TPSHGSPISHGPPAIHPTSP", "down_seq": "PPSTASGANSATNGGTSNCL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr301", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "243", "end_pos": "243" }, { "start_pos": "281", "end_pos": "281" }, { "start_pos": "301", "end_pos": "301" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 20, "direction": "downstream", "id": "A0A8C2QMV3-1.281.281", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QNE7-1.163.163", "start_pos": 163, "end_pos": 163, "uniprot_canonical_ac": "A0A8C2QNE7-1", "length": 411, "uniprot_id": "A0A8C2QNE7_CRIGR", "protein_name": "Eukaryotic initiation factor 4A-III", "refseq_ac": "XP_007645429", "refseq_name": "eukaryotic initiation factor 4A-III isoform X1", "gene_name": "Eif4a3", "gene_names_uniprotkb": "Eif4a3", "gene_names_refseq": "Eif4a3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QNE7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QNE7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GTNVGEDIRKLDYGQHVVAG", "down_seq": "PGRVFDMIRRRSLRTRAIKM", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr163", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "163", "end_pos": "163" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QNF1-1.506.506", "start_pos": 506, "end_pos": 506, "uniprot_canonical_ac": "A0A8C2QNF1-1", "length": 856, "uniprot_id": "A0A8C2QNF1_CRIGR", "protein_name": "GAS2-like protein 2", "refseq_ac": "XP_003511349", "refseq_name": "GAS2-like protein 2", "gene_name": "Gas2l2", "gene_names_uniprotkb": "Gas2l2", "gene_names_refseq": "Gas2l2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QNF1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QNF1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PPPSKGFTKIPIRLSPAQPP", "down_seq": "PGRSVLGAESGGSIERGPIP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr506", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "506", "end_pos": "506" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QNV8-1.132.132", "start_pos": 132, "end_pos": 132, "uniprot_canonical_ac": "A0A8C2QNV8-1", "length": 1160, "uniprot_id": "A0A8C2QNV8_CRIGR", "protein_name": "[histone H3]-dimethyl-L-lysine(36) demethylase", "refseq_ac": "XP_003509993", "refseq_name": "lysine-specific demethylase 2A isoform X3", "gene_name": "Kdm2a", "gene_names_uniprotkb": "Kdm2a", "gene_names_refseq": "Kdm2a", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QNV8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QNV8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DVNTQKGIEMTMAQWTRYYE", "down_seq": "PEEEREKLYNVISLEFSHTR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr132", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "132", "end_pos": "132" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QPB0-1.39.39", "start_pos": 39, "end_pos": 39, "uniprot_canonical_ac": "A0A8C2QPB0-1", "length": 347, "uniprot_id": "A0A8C2QPB0_CRIGR", "protein_name": "mitogen-activated protein kinase kinase", "refseq_ac": "XP_027283065", "refseq_name": "dual specificity mitogen-activated protein kinase kinase 3 isoform X3", "gene_name": "Map2k3", "gene_names_uniprotkb": "Map2k3", "gene_names_refseq": "Map2k3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QPB0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QPB0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SKRKKDLRITCVSKPPAPNP", "down_seq": "PPRNLDSRAFITIGDRNFEV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr39", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "39", "end_pos": "39" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QPH8-1.314.314", "start_pos": 314, "end_pos": 314, "uniprot_canonical_ac": "A0A8C2QPH8-1", "length": 733, "uniprot_id": "A0A8C2QPH8_CRIGR", "protein_name": "DNA polymerase iota", "refseq_ac": "XP_027258438", "refseq_name": "DNA polymerase iota isoform X4", "gene_name": "Poli", "gene_names_uniprotkb": "Poli", "gene_names_refseq": "Poli", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QPH8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QPH8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GISVAQRIQKLSFGEDNSPV", "down_seq": "PSGPPQSFSEEDTFKKCSSE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr314", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "314", "end_pos": "314" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QPQ0-1.508.508", "start_pos": 508, "end_pos": 508, "uniprot_canonical_ac": "A0A8C2QPQ0-1", "length": 547, "uniprot_id": "A0A8C2QPQ0_CRIGR", "protein_name": "Alkaline phosphatase", "refseq_ac": "XP_027251878", "refseq_name": "intestinal-type alkaline phosphatase 1 isoform X2", "gene_name": "LOC100751774", "gene_names_uniprotkb": "LOC100751774", "gene_names_refseq": "LOC100751774", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QPQ0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QPQ0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "CLEPYTDCGLAPPAGQSSPI", "down_seq": "PGQINTEVTNSAAHQGTIQL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr508", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "508", "end_pos": "508" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QPU2-1.88.88", "start_pos": 88, "end_pos": 88, "uniprot_canonical_ac": "A0A8C2QPU2-1", "length": 245, "uniprot_id": "A0A8C2QPU2_CRIGR", "protein_name": "Complement C1q subcomponent subunit A", "refseq_ac": "XP_035295195", "refseq_name": "complement C1q subcomponent subunit A", "gene_name": "C1qa", "gene_names_uniprotkb": "C1qa", "gene_names_refseq": "C1qa", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QPU2", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QPU2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GDQGESGPPGKPGNMGFPGP", "down_seq": "GPLGSSGPQGLKGVKGNPGN", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr88", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "88", "end_pos": "88" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EUZ7-1.499.499", "start_pos": 499, "end_pos": 499, "uniprot_canonical_ac": "A0A9J7EUZ7-1", "length": 559, "uniprot_id": "A0A9J7EUZ7_CRIGR", "protein_name": "Probable cysteine--tRNA ligase, mitochondrial", "refseq_ac": "XP_016834558", "refseq_name": "probable cysteine--tRNA ligase, mitochondrial isoform X1", "gene_name": "Cars2", "gene_names_uniprotkb": "Cars2", "gene_names_refseq": "Cars2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EUZ7", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EUZ7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "HSVVDELVRFRLKVRQYALA", "down_seq": "PGATGETRRQQLQERQPLLE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr499", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "499", "end_pos": "499" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EV45-1.727.727", "start_pos": 727, "end_pos": 727, "uniprot_canonical_ac": "A0A9J7EV45-1", "length": 963, "uniprot_id": "A0A9J7EV45_CRIGR", "protein_name": "Uncharacterized protein LOC113832278; Uncharacterized protein LOC113832852; Uncharacterized protein LOC113833203; Uncharacterized protein LOC113834356; Uncharacterized protein LOC113836798; Uncharacterized protein LOC113837033", "refseq_ac": "XP_027243088", "refseq_name": "uncharacterized protein LOC113832278", "gene_name": "LOC113832278", "gene_names_uniprotkb": "LOC113832278; LOC113832852; LOC113833203; LOC113834356; LOC113836798; LOC113837033", "gene_names_refseq": "LOC113832278", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EV45", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EV45" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AALTTDTTSLLALEPTNDRP", "down_seq": "PSWDYEQRDIQTLEKLGATK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr727", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "727", "end_pos": "727" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EVU2-1.1514.1514", "start_pos": 1514, "end_pos": 1514, "uniprot_canonical_ac": "A0A9J7EVU2-1", "length": 1878, "uniprot_id": "A0A9J7EVU2_CRIGR", "protein_name": "Unconventional myosin-XVI", "refseq_ac": "XP_027243683", "refseq_name": "unconventional myosin-XVI", "gene_name": "Myo16", "gene_names_uniprotkb": "Myo16", "gene_names_refseq": "Myo16", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EVU2", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EVU2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "IPPPFPNLLPHRPPLLVFPP", "down_seq": "PVTCSPASDESPLTPLEVKK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1514", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1514", "end_pos": "1514" }, { "start_pos": "1588", "end_pos": "1588" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EVU2-1.1588.1588", "start_pos": 1588, "end_pos": 1588, "uniprot_canonical_ac": "A0A9J7EVU2-1", "length": 1878, "uniprot_id": "A0A9J7EVU2_CRIGR", "protein_name": "Unconventional myosin-XVI", "refseq_ac": "XP_027243683", "refseq_name": "unconventional myosin-XVI", "gene_name": "Myo16", "gene_names_uniprotkb": "Myo16", "gene_names_refseq": "Myo16", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EVU2", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EVU2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QPASPGFTVFNGSSRVSPPS", "down_seq": "PPPPPGPPPAPCGPVPAPCR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1588", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1514", "end_pos": "1514" }, { "start_pos": "1588", "end_pos": "1588" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EVX3-1.128.128", "start_pos": 128, "end_pos": 128, "uniprot_canonical_ac": "A0A9J7EVX3-1", "length": 488, "uniprot_id": "A0A9J7EVX3_CRIGR", "protein_name": "E3 ubiquitin-protein ligase TRIM39", "refseq_ac": "XP_027244400", "refseq_name": "E3 ubiquitin-protein ligase TRIM39 isoform X1", "gene_name": "LOC100761611", "gene_names_uniprotkb": "LOC100761611", "gene_names_refseq": "LOC100761611", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EVX3", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EVX3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "FEHQEAMSLLCYEDQEAVCP", "down_seq": "CAIYHTQQAHTILQLDDVTK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr128", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "128", "end_pos": "128" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EW05-1.130.130", "start_pos": 130, "end_pos": 130, "uniprot_canonical_ac": "A0A9J7EW05-1", "length": 1262, "uniprot_id": "A0A9J7EW05_CRIGR", "protein_name": "[histone H3]-lysine(9) N-methyltransferase", "refseq_ac": "XP_027244587", "refseq_name": "LOW QUALITY PROTEIN: histone-lysine N-methyltransferase EHMT2 isoform X2", "gene_name": "Ehmt2", "gene_names_uniprotkb": "Ehmt2", "gene_names_refseq": "Ehmt2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EW05", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EW05" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "KADPDSLEPAGPSSPASVTV", "down_seq": "VGDEGADTPAGAAPLLGDEP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr130", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "130", "end_pos": "130" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "607", "end_pos": "607" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EW05-1.22.22", "start_pos": 22, "end_pos": 22, "uniprot_canonical_ac": "A0A9J7EW05-1", "length": 1262, "uniprot_id": "A0A9J7EW05_CRIGR", "protein_name": "[histone H3]-lysine(9) N-methyltransferase", "refseq_ac": "XP_027244587", "refseq_name": "LOW QUALITY PROTEIN: histone-lysine N-methyltransferase EHMT2 isoform X2", "gene_name": "Ehmt2", "gene_names_uniprotkb": "Ehmt2", "gene_names_refseq": "Ehmt2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EW05", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EW05" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RGLPRGRGPMRARGRGXSGP", "down_seq": "GGRGRGRGGAHRGRGRPRSL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr22", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "130", "end_pos": "130" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "607", "end_pos": "607" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EW05-1.607.607", "start_pos": 607, "end_pos": 607, "uniprot_canonical_ac": "A0A9J7EW05-1", "length": 1262, "uniprot_id": "A0A9J7EW05_CRIGR", "protein_name": "[histone H3]-lysine(9) N-methyltransferase", "refseq_ac": "XP_027244587", "refseq_name": "LOW QUALITY PROTEIN: histone-lysine N-methyltransferase EHMT2 isoform X2", "gene_name": "Ehmt2", "gene_names_uniprotkb": "Ehmt2", "gene_names_refseq": "Ehmt2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EW05", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EW05" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "HCGEDASEAQEVTIPRGDGG", "down_seq": "PPAGTAAPAPLPLAQDAPGR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr607", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "130", "end_pos": "130" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "607", "end_pos": "607" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EX01-1.1850.1850", "start_pos": 1850, "end_pos": 1850, "uniprot_canonical_ac": "A0A9J7EX01-1", "length": 4251, "uniprot_id": "A0A9J7EX01_CRIGR", "protein_name": "Dynein axonemal heavy chain 1", "refseq_ac": "XP_003495342", "refseq_name": "dynein heavy chain 1, axonemal", "gene_name": "Dnah1", "gene_names_uniprotkb": "Dnah1", "gene_names_refseq": "Dnah1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EX01", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EX01" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "KCIQLYETTVVRHGLMLVGP", "down_seq": "GSGKSNCYRVLAAAMTFLKG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1850", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1850", "end_pos": "1850" }, { "start_pos": "2215", "end_pos": "2215" }, { "start_pos": "2340", "end_pos": "2340" }, { "start_pos": "2416", "end_pos": "2416" }, { "start_pos": "2789", "end_pos": "2789" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EX01-1.2215.2215", "start_pos": 2215, "end_pos": 2215, "uniprot_canonical_ac": "A0A9J7EX01-1", "length": 4251, "uniprot_id": "A0A9J7EX01_CRIGR", "protein_name": "Dynein axonemal heavy chain 1", "refseq_ac": "XP_003495342", "refseq_name": "dynein heavy chain 1, axonemal", "gene_name": "Dnah1", "gene_names_uniprotkb": "Dnah1", "gene_names_refseq": "Dnah1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EX01", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EX01" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MSFLLGMLITNNKPVLCIGP", "down_seq": "GTGKTLTVSNKLLRNLPLEY", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2215", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1850", "end_pos": "1850" }, { "start_pos": "2215", "end_pos": "2215" }, { "start_pos": "2340", "end_pos": "2340" }, { "start_pos": "2416", "end_pos": "2416" }, { "start_pos": "2789", "end_pos": "2789" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EX01-1.2340.2340", "start_pos": 2340, "end_pos": 2340, "uniprot_canonical_ac": "A0A9J7EX01-1", "length": 4251, "uniprot_id": "A0A9J7EX01_CRIGR", "protein_name": "Dynein axonemal heavy chain 1", "refseq_ac": "XP_003495342", "refseq_name": "dynein heavy chain 1, axonemal", "gene_name": "Dnah1", "gene_names_uniprotkb": "Dnah1", "gene_names_refseq": "Dnah1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EX01", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EX01" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LVDINFVCAMGPPGGGRNAI", "down_seq": "PRLTRHFNYLSFIEMDEVSK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2340", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1850", "end_pos": "1850" }, { "start_pos": "2215", "end_pos": "2215" }, { "start_pos": "2340", "end_pos": "2340" }, { "start_pos": "2416", "end_pos": "2416" }, { "start_pos": "2789", "end_pos": "2789" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EX01-1.2416.2416", "start_pos": 2416, "end_pos": 2416, "uniprot_canonical_ac": "A0A9J7EX01-1", "length": 4251, "uniprot_id": "A0A9J7EX01_CRIGR", "protein_name": "Dynein axonemal heavy chain 1", "refseq_ac": "XP_003495342", "refseq_name": "dynein heavy chain 1, axonemal", "gene_name": "Dnah1", "gene_names_uniprotkb": "Dnah1", "gene_names_refseq": "Dnah1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EX01", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EX01" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EPLVEATIRVYATITSQLLP", "down_seq": "PAKSHYTFNLRDLSKVFQGM", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2416", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1850", "end_pos": "1850" }, { "start_pos": "2215", "end_pos": "2215" }, { "start_pos": "2340", "end_pos": "2340" }, { "start_pos": "2416", "end_pos": "2416" }, { "start_pos": "2789", "end_pos": "2789" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EX01-1.2789.2789", "start_pos": 2789, "end_pos": 2789, "uniprot_canonical_ac": "A0A9J7EX01-1", "length": 4251, "uniprot_id": "A0A9J7EX01_CRIGR", "protein_name": "Dynein axonemal heavy chain 1", "refseq_ac": "XP_003495342", "refseq_name": "dynein heavy chain 1, axonemal", "gene_name": "Dnah1", "gene_names_uniprotkb": "Dnah1", "gene_names_refseq": "Dnah1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EX01", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EX01" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QSVAKKCIEYLAELARHNYV", "down_seq": "PKSYLELLNIFSILIGQKKM", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2789", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1850", "end_pos": "1850" }, { "start_pos": "2215", "end_pos": "2215" }, { "start_pos": "2340", "end_pos": "2340" }, { "start_pos": "2416", "end_pos": "2416" }, { "start_pos": "2789", "end_pos": "2789" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F679-1.502.502", "start_pos": 502, "end_pos": 502, "uniprot_canonical_ac": "A0A9J7F679-1", "length": 1278, "uniprot_id": "A0A9J7F679_CRIGR", "protein_name": "Ankyrin repeat and sterile alpha motif domain-containing protein 1B", "refseq_ac": "XP_027248403", "refseq_name": "ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X2", "gene_name": "Anks1b", "gene_names_uniprotkb": "Anks1b", "gene_names_refseq": "Anks1b", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F679", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F679" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SEVAITAPGTGHHRNSSTGP", "down_seq": "PDCSPPSPDTALKNIVKVIR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr502", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "502", "end_pos": "502" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F5M0-1.285.285", "start_pos": 285, "end_pos": 285, "uniprot_canonical_ac": "A0A9J7F5M0-1", "length": 925, "uniprot_id": "A0A9J7F5M0_CRIGR", "protein_name": "Protein O-mannosyl-transferase TMTC3", "refseq_ac": "XP_016831711", "refseq_name": "protein O-mannosyl-transferase TMTC3 isoform X1", "gene_name": "Tmtc3", "gene_names_uniprotkb": "Tmtc3", "gene_names_refseq": "Tmtc3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F5M0", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F5M0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VIQSQLPVFTRFDNPAAVSP", "down_seq": "PTRQLTFNYLLPVNAWLLLN", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr285", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "285", "end_pos": "285" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F0T6-1.151.151", "start_pos": 151, "end_pos": 151, "uniprot_canonical_ac": "A0A9J7F0T6-1", "length": 710, "uniprot_id": "A0A9J7F0T6_CRIGR", "protein_name": "Death domain-associated protein 6", "refseq_ac": "XP_027244774", "refseq_name": "death domain-associated protein 6 isoform X1", "gene_name": "Daxx", "gene_names_uniprotkb": "Daxx", "gene_names_refseq": "Daxx", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F0T6", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F0T6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "CTVLKAHSNKKKLNLAPAPS", "down_seq": "PSKPSGDNPPTESSSELTNA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr151", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "151", "end_pos": "151" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EYQ8-1.48.48", "start_pos": 48, "end_pos": 48, "uniprot_canonical_ac": "A0A9J7EYQ8-1", "length": 1233, "uniprot_id": "A0A9J7EYQ8_CRIGR", "protein_name": "Diacylglycerol kinase", "refseq_ac": "XP_027245878", "refseq_name": "diacylglycerol kinase eta isoform X2", "gene_name": "Dgkh", "gene_names_uniprotkb": "Dgkh", "gene_names_refseq": "Dgkh", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EYQ8", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EYQ8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AGSQHHPPGGAAAGTSAVSP", "down_seq": "AAGPGEDSSDSEAEQEGPQK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr48", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "48", "end_pos": "48" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EXY7-1.1124.1124", "start_pos": 1124, "end_pos": 1124, "uniprot_canonical_ac": "A0A9J7EXY7-1", "length": 2490, "uniprot_id": "A0A9J7EXY7_CRIGR", "protein_name": "Tyrosine-protein phosphatase non-receptor type 13", "refseq_ac": "XP_027244301", "refseq_name": "LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 13 isoform X4", "gene_name": "Ptpn13", "gene_names_uniprotkb": "Ptpn13", "gene_names_refseq": "Ptpn13", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EXY7", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EXY7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QIIGGEKMGRLDLGVFISSV", "down_seq": "PGGPADLDGCLKPGDRLISV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1124", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1124", "end_pos": "1124" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EY47-1.150.150", "start_pos": 150, "end_pos": 150, "uniprot_canonical_ac": "A0A9J7EY47-1", "length": 249, "uniprot_id": "A0A9J7EY47_CRIGR", "protein_name": "Cyclin-dependent kinase inhibitor 3", "refseq_ac": "XP_027242334", "refseq_name": "cyclin-dependent kinase inhibitor 3 isoform X3", "gene_name": "Cdkn3", "gene_names_uniprotkb": "Cdkn3", "gene_names_refseq": "Cdkn3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EY47", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EY47" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LDLYQQSGIVTHHHPIPDGG", "down_seq": "PDIGSCWQIMEELATCLKNN", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr150", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "150", "end_pos": "150" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EYW7-1.49.49", "start_pos": 49, "end_pos": 49, "uniprot_canonical_ac": "A0A9J7EYW7-1", "length": 567, "uniprot_id": "A0A9J7EYW7_CRIGR", "protein_name": "Poly [ADP-ribose] polymerase", "refseq_ac": "XP_007647986", "refseq_name": "poly [ADP-ribose] polymerase 2 isoform X1", "gene_name": "Parp2", "gene_names_uniprotkb": "Parp2", "gene_names_refseq": "Parp2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EYW7", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EYW7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "KATEDFPPGKKMRTCQRKGP", "down_seq": "AGGKDADRTNSQQDTVKALL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr49", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "49", "end_pos": "49" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EYF2-1.269.269", "start_pos": 269, "end_pos": 269, "uniprot_canonical_ac": "A0A9J7EYF2-1", "length": 354, "uniprot_id": "A0A9J7EYF2_CRIGR", "protein_name": "Paraoxonase", "refseq_ac": "XP_007645374", "refseq_name": "serum paraoxonase/arylesterase 2", "gene_name": "Pon2", "gene_names_uniprotkb": "Pon2", "gene_names_refseq": "Pon2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EYF2", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EYF2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A9J7EYF2", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EYF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR602640-4", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR602640-4", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "KQPNMNLTQLKVLQLGTLVD", "down_seq": "LSIDPSSGDIWVGCHPNGQK", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn269", "evidence": [ { "id": "A0A9J7EYF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EYF2#ptm_processing" }, { "id": "PIRSR602640-4", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR602640-4" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "269", "end_pos": "269" }, { "start_pos": "323", "end_pos": "323" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EYF2-1.323.323", "start_pos": 323, "end_pos": 323, "uniprot_canonical_ac": "A0A9J7EYF2-1", "length": 354, "uniprot_id": "A0A9J7EYF2_CRIGR", "protein_name": "Paraoxonase", "refseq_ac": "XP_007645374", "refseq_name": "serum paraoxonase/arylesterase 2", "gene_name": "Pon2", "gene_names_uniprotkb": "Pon2", "gene_names_refseq": "Pon2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EYF2", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EYF2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A9J7EYF2", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EYF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR602640-4", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR602640-4", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "VLRIQNILSEKPSVTTVYIN", "down_seq": "GSVLQGSSVATIYDRKLLVG", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn323", "evidence": [ { "id": "A0A9J7EYF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EYF2#ptm_processing" }, { "id": "PIRSR602640-4", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR602640-4" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "269", "end_pos": "269" }, { "start_pos": "323", "end_pos": "323" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EYI0-1.3.3", "start_pos": 3, "end_pos": 3, "uniprot_canonical_ac": "A0A9J7EYI0-1", "length": 649, "uniprot_id": "A0A9J7EYI0_CRIGR", "protein_name": "Carboxypeptidase Z", "refseq_ac": "XP_027242923", "refseq_name": "carboxypeptidase Z", "gene_name": "Cpz", "gene_names_uniprotkb": "Cpz", "gene_names_refseq": "Cpz", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EYI0", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EYI0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MP", "down_seq": "PPLLLAVLATLAAAAHPSCS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "3", "end_pos": "3" }, { "start_pos": "405", "end_pos": "405" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EYI0-1.405.405", "start_pos": 405, "end_pos": 405, "uniprot_canonical_ac": "A0A9J7EYI0-1", "length": 649, "uniprot_id": "A0A9J7EYI0_CRIGR", "protein_name": "Carboxypeptidase Z", "refseq_ac": "XP_027242923", "refseq_name": "carboxypeptidase Z", "gene_name": "Cpz", "gene_names_uniprotkb": "Cpz", "gene_names_refseq": "Cpz", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EYI0", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EYI0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VVSYPFDFSKHPHEEKMFSP", "down_seq": "PDEKMFKLLARAYADVHPMM", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr405", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "3", "end_pos": "3" }, { "start_pos": "405", "end_pos": "405" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EYS3-1.90.90", "start_pos": 90, "end_pos": 90, "uniprot_canonical_ac": "A0A9J7EYS3-1", "length": 993, "uniprot_id": "A0A9J7EYS3_CRIGR", "protein_name": "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A", "refseq_ac": "XP_027243079", "refseq_name": "phosphatidylinositol 4,5-bisphosphate 5-phosphatase A", "gene_name": "Inpp5j", "gene_names_uniprotkb": "Inpp5j", "gene_names_refseq": "Inpp5j", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EYS3", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EYS3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PSEGPRPALASPRPIPASLS", "down_seq": "PGEQKRPPVHRSSNLASASV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr90", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "90", "end_pos": "90" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EZD3-1.127.127", "start_pos": 127, "end_pos": 127, "uniprot_canonical_ac": "A0A9J7EZD3-1", "length": 785, "uniprot_id": "A0A9J7EZD3_CRIGR", "protein_name": "Chromosome alignment-maintaining phosphoprotein 1", "refseq_ac": "XP_027243586", "refseq_name": "chromosome alignment-maintaining phosphoprotein 1", "gene_name": "Champ1", "gene_names_uniprotkb": "Champ1", "gene_names_refseq": "Champ1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EZD3", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EZD3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "KSPSLPEHQSTAFDPAEVRP", "down_seq": "PALPVETQKTGPSLSPEPQK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr127", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "127", "end_pos": "127" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F0J6-1.1140.1140", "start_pos": 1140, "end_pos": 1140, "uniprot_canonical_ac": "A0A9J7F0J6-1", "length": 1270, "uniprot_id": "A0A9J7F0J6_CRIGR", "protein_name": "non-specific serine/threonine protein kinase", "refseq_ac": "XP_027247302", "refseq_name": "homeodomain-interacting protein kinase 2 isoform X6", "gene_name": "Hipk2", "gene_names_uniprotkb": "Hipk2", "gene_names_refseq": "Hipk2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F0J6", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F0J6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QHMATDRTGNHRRQQAYITP", "down_seq": "MAQAPYTFPHNSPSHGTVHP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1140", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1140", "end_pos": "1140" }, { "start_pos": "958", "end_pos": "958" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F0J6-1.958.958", "start_pos": 958, "end_pos": 958, "uniprot_canonical_ac": "A0A9J7F0J6-1", "length": 1270, "uniprot_id": "A0A9J7F0J6_CRIGR", "protein_name": "non-specific serine/threonine protein kinase", "refseq_ac": "XP_027247302", "refseq_name": "homeodomain-interacting protein kinase 2 isoform X6", "gene_name": "Hipk2", "gene_names_uniprotkb": "Hipk2", "gene_names_refseq": "Hipk2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F0J6", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F0J6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SSTTRERQRQTIVIPDTPSP", "down_seq": "VSVITISSDTDEEEEQKHAP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr958", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1140", "end_pos": "1140" }, { "start_pos": "958", "end_pos": "958" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EZP2-1.41.41", "start_pos": 41, "end_pos": 41, "uniprot_canonical_ac": "A0A9J7EZP2-1", "length": 234, "uniprot_id": "A0A9J7EZP2_CRIGR", "protein_name": "Nucleophosmin", "refseq_ac": "XP_027247424", "refseq_name": "nucleophosmin-like", "gene_name": "LOC100760757", "gene_names_uniprotkb": "LOC100760757", "gene_names_refseq": "LOC100760757", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EZP2", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EZP2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "NYEGSPIKVTLATLKMSVQP", "down_seq": "VSLGGFEITPPVVLWLRGGS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr41", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "41", "end_pos": "41" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EZU3-1.881.881", "start_pos": 881, "end_pos": 881, "uniprot_canonical_ac": "A0A9J7EZU3-1", "length": 894, "uniprot_id": "A0A9J7EZU3_CRIGR", "protein_name": "adenylate cyclase", "refseq_ac": "XP_016832117", "refseq_name": "adenylate cyclase type 1", "gene_name": "Adcy1", "gene_names_uniprotkb": "Adcy1", "gene_names_refseq": "Adcy1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EZU3", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EZU3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RPPLCPAAGPPIRPGLPPAP", "down_seq": "SQYLPSTAGGKEA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr881", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "881", "end_pos": "881" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7EZX4-1.438.438", "start_pos": 438, "end_pos": 438, "uniprot_canonical_ac": "A0A9J7EZX4-1", "length": 802, "uniprot_id": "A0A9J7EZX4_CRIGR", "protein_name": "Cell division cycle 5-like protein", "refseq_ac": "XP_027243224", "refseq_name": "cell division cycle 5-like protein isoform X2", "gene_name": "Cdc5l", "gene_names_uniprotkb": "Cdc5l", "gene_names_refseq": "Cdc5l", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7EZX4", "url": "https://www.uniprot.org/uniprotkb/A0A9J7EZX4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "NGAEGLTPRSGTTPKQVTNA", "down_seq": "PGRTPLRDKLNINPEDGMAD", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr438", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "438", "end_pos": "438" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F2S9-1.287.287", "start_pos": 287, "end_pos": 287, "uniprot_canonical_ac": "A0A9J7F2S9-1", "length": 431, "uniprot_id": "A0A9J7F2S9_CRIGR", "protein_name": "Interferon regulatory factor 9", "refseq_ac": "XP_007640866", "refseq_name": "interferon regulatory factor 9 isoform X1", "gene_name": "Irf9", "gene_names_uniprotkb": "Irf9", "gene_names_refseq": "Irf9", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F2S9", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F2S9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "CRLVADPSVSESNMPQVVFP", "down_seq": "PDPLEPIQHLLSQLERGILV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr287", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "287", "end_pos": "287" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F5Z6-1.637.637", "start_pos": 637, "end_pos": 637, "uniprot_canonical_ac": "A0A9J7F5Z6-1", "length": 1031, "uniprot_id": "A0A9J7F5Z6_CRIGR", "protein_name": "Protein phosphatase 1 regulatory subunit", "refseq_ac": "XP_027248259", "refseq_name": "protein phosphatase 1 regulatory subunit 12A isoform X5", "gene_name": "Ppp1r12a", "gene_names_uniprotkb": "Ppp1r12a", "gene_names_refseq": "Ppp1r12a", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F5Z6", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F5Z6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DSTEKEKDSAPTAVTIPVAP", "down_seq": "VVNAAASTTTLTTTTAGTVS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr637", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "637", "end_pos": "637" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F149-1.266.266", "start_pos": 266, "end_pos": 266, "uniprot_canonical_ac": "A0A9J7F149-1", "length": 715, "uniprot_id": "A0A9J7F149_CRIGR", "protein_name": "Ubiquitin carboxyl-terminal hydrolase", "refseq_ac": "XP_003501468", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 44", "gene_name": "Usp44", "gene_names_uniprotkb": "Usp44", "gene_names_refseq": "Usp44", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F149", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F149" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SEDGRLKKVSDCLIKRRPAV", "down_seq": "PGVTGLRNLGNTCYMNSVLQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr266", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "266", "end_pos": "266" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F1E5-1.174.174", "start_pos": 174, "end_pos": 174, "uniprot_canonical_ac": "A0A9J7F1E5-1", "length": 1006, "uniprot_id": "A0A9J7F1E5_CRIGR", "protein_name": "DNA-dependent ATPase/E3 ubiquitin-protein ligase HLTF", "refseq_ac": "XP_027247904", "refseq_name": "helicase-like transcription factor", "gene_name": "Hltf", "gene_names_uniprotkb": "Hltf", "gene_names_refseq": "Hltf", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F1E5", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F1E5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EENRKVVLNQLTKHGFKLGP", "down_seq": "PKNAGLSLENSWSSGRAGPS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr174", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "174", "end_pos": "174" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F1F4-1.168.168", "start_pos": 168, "end_pos": 168, "uniprot_canonical_ac": "A0A9J7F1F4-1", "length": 744, "uniprot_id": "A0A9J7F1F4_CRIGR", "protein_name": "Pro-neuregulin-3, membrane-bound isoform", "refseq_ac": "XP_027245224", "refseq_name": "pro-neuregulin-3, membrane-bound isoform isoform X2", "gene_name": "Nrg3", "gene_names_uniprotkb": "Nrg3", "gene_names_refseq": "Nrg3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F1F4", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F1F4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SSFPKAMETTTTTTSTMSPA", "down_seq": "PSAGGAASSRTPNRISTRLT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr168", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "168", "end_pos": "168" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F4B8-1.1462.1462", "start_pos": 1462, "end_pos": 1462, "uniprot_canonical_ac": "A0A9J7F4B8-1", "length": 1680, "uniprot_id": "A0A9J7F4B8_CRIGR", "protein_name": "Phosphoinositide phospholipase C", "refseq_ac": "XP_027247515", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1", "gene_name": "Plch1", "gene_names_uniprotkb": "Plch1", "gene_names_refseq": "Plch1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F4B8", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F4B8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MNQICVPQKSRVPDMHAPTP", "down_seq": "QSTHAPLVALKLPSPCKSKS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1462", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1462", "end_pos": "1462" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F2L0-1.400.400", "start_pos": 400, "end_pos": 400, "uniprot_canonical_ac": "A0A9J7F2L0-1", "length": 540, "uniprot_id": "A0A9J7F2L0_CRIGR", "protein_name": "Receptor-interacting serine/threonine-protein kinase 3", "refseq_ac": "XP_007640854", "refseq_name": "receptor-interacting serine/threonine-protein kinase 3", "gene_name": "Ripk3", "gene_names_uniprotkb": "Ripk3", "gene_names_refseq": "Ripk3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F2L0", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F2L0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SSDTVAGTPQMPHTIPFRGP", "down_seq": "PGPNSAETPGPNPQRNEGYE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr400", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "400", "end_pos": "400" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F300-1.127.127", "start_pos": 127, "end_pos": 127, "uniprot_canonical_ac": "A0A9J7F300-1", "length": 376, "uniprot_id": "A0A9J7F300_CRIGR", "protein_name": "tRNA (guanine-N(7)-)-methyltransferase", "refseq_ac": "XP_027248066", "refseq_name": "tRNA (guanine-N(7)-)-methyltransferase", "gene_name": "Mettl1", "gene_names_uniprotkb": "Mettl1; METTL1", "gene_names_refseq": "Mettl1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F300", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F300" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A9J7F300", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F300", "database": "UniProtKB", "categories": [ "Protein" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "IMAGTEAPQPQKRYYRQRAH", "down_seq": "NPMADHTLCYPVKPEEMDWS", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PKB and RPS6KA3", "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F300", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F300" } ], "site_lbl": "Ser127" } ], "all_sites": [ { "type": "phosphorylation", "site_list": [ { "start_pos": "127", "end_pos": "127" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F3E7-1.889.889", "start_pos": 889, "end_pos": 889, "uniprot_canonical_ac": "A0A9J7F3E7-1", "length": 1797, "uniprot_id": "A0A9J7F3E7_CRIGR", "protein_name": "Collagen alpha-1(XVIII) chain", "refseq_ac": "XP_027250076", "refseq_name": "collagen alpha-1(XVIII) chain isoform X4", "gene_name": "Col18a1", "gene_names_uniprotkb": "Col18a1", "gene_names_refseq": "Col18a1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F3E7", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F3E7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PGDPGEDGRPGDTGPQGFPG", "down_seq": "PGEVGPKGEKGDPGVGARGP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr889", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "889", "end_pos": "889" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F3E9-1.2452.2452", "start_pos": 2452, "end_pos": 2452, "uniprot_canonical_ac": "A0A9J7F3E9-1", "length": 2551, "uniprot_id": "A0A9J7F3E9_CRIGR", "protein_name": "Stabilin-2", "refseq_ac": "XP_027248352", "refseq_name": "stabilin-2 isoform X2", "gene_name": "Stab2", "gene_names_uniprotkb": "Stab2", "gene_names_refseq": "Stab2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F3E9", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F3E9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ASNGLIHIISEPLEAPPMTA", "down_seq": "PAHTGLGTGIVCAVILVTGA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2452", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "2452", "end_pos": "2452" }, { "start_pos": "2521", "end_pos": "2521" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F3E9-1.2521.2521", "start_pos": 2521, "end_pos": 2521, "uniprot_canonical_ac": "A0A9J7F3E9-1", "length": 2551, "uniprot_id": "A0A9J7F3E9_CRIGR", "protein_name": "Stabilin-2", "refseq_ac": "XP_027248352", "refseq_name": "stabilin-2 isoform X2", "gene_name": "Stab2", "gene_names_uniprotkb": "Stab2", "gene_names_refseq": "Stab2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F3E9", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F3E9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VLAFGKQQAENISNPVYESS", "down_seq": "PAPPETSGDPFTDSEEQEEE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2521", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "2452", "end_pos": "2452" }, { "start_pos": "2521", "end_pos": "2521" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F3G1-1.453.453", "start_pos": 453, "end_pos": 453, "uniprot_canonical_ac": "A0A9J7F3G1-1", "length": 606, "uniprot_id": "A0A9J7F3G1_CRIGR", "protein_name": "Endonuclease 8-like 3", "refseq_ac": "XP_027246847", "refseq_name": "endonuclease 8-like 3 isoform X1", "gene_name": "Neil3", "gene_names_uniprotkb": "Neil3", "gene_names_refseq": "Neil3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F3G1", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F3G1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PSKEGANYITQPSNRVNISP", "down_seq": "VCAQSKLFSSAHKKLKTAHS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr453", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "453", "end_pos": "453" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F3R3-1.522.522", "start_pos": 522, "end_pos": 522, "uniprot_canonical_ac": "A0A9J7F3R3-1", "length": 798, "uniprot_id": "A0A9J7F3R3_CRIGR", "protein_name": "non-specific serine/threonine protein kinase", "refseq_ac": "XP_027247331", "refseq_name": "LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf isoform X6", "gene_name": "Braf", "gene_names_uniprotkb": "Braf", "gene_names_refseq": "Braf", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F3R3", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F3R3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VYKGKWHGDVAVKMLNVTAP", "down_seq": "PQQLQAFKNEVGVLRKTRHV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr522", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "522", "end_pos": "522" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F3Y1-1.757.757", "start_pos": 757, "end_pos": 757, "uniprot_canonical_ac": "A0A9J7F3Y1-1", "length": 782, "uniprot_id": "A0A9J7F3Y1_CRIGR", "protein_name": "Cadherin-24", "refseq_ac": "XP_027246431", "refseq_name": "cadherin-24 isoform X2", "gene_name": "Cdh24", "gene_names_uniprotkb": "Cdh24", "gene_names_refseq": "Cdh24", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F3Y1", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F3Y1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SCGSLSSLGSGSEAGGVPGP", "down_seq": "EPLDDWGPLFRTLAELYGAK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr757", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "757", "end_pos": "757" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F464-1.1281.1281", "start_pos": 1281, "end_pos": 1281, "uniprot_canonical_ac": "A0A9J7F464-1", "length": 2189, "uniprot_id": "A0A9J7F464_CRIGR", "protein_name": "Unconventional myosin-IXb isoform X6", "refseq_ac": "XP_027250629", "refseq_name": "unconventional myosin-IXb isoform X6", "gene_name": "Myo9b", "gene_names_uniprotkb": "Myo9b", "gene_names_refseq": "Myo9b", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F464", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F464" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PPGSPSPMHRPTSLALDSRV", "down_seq": "PGVPSSTPESPKDKDNGGDS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1281", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1281", "end_pos": "1281" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F5G2-1.371.371", "start_pos": 371, "end_pos": 371, "uniprot_canonical_ac": "A0A9J7F5G2-1", "length": 609, "uniprot_id": "A0A9J7F5G2_CRIGR", "protein_name": "Nephronectin", "refseq_ac": "XP_027251534", "refseq_name": "nephronectin isoform X2", "gene_name": "Npnt", "gene_names_uniprotkb": "Npnt", "gene_names_refseq": "Npnt", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F5G2", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F5G2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PPVITIRPTYRPTTRPTPNP", "down_seq": "PQPTPPPPPPLPTELKTTPL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr371", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "371", "end_pos": "371" }, { "start_pos": "375", "end_pos": "375" }, { "start_pos": "394", "end_pos": "394" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "upstream", "id": "A0A9J7F5G2-1.375.375", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F5G2-1.375.375", "start_pos": 375, "end_pos": 375, "uniprot_canonical_ac": "A0A9J7F5G2-1", "length": 609, "uniprot_id": "A0A9J7F5G2_CRIGR", "protein_name": "Nephronectin", "refseq_ac": "XP_027251534", "refseq_name": "nephronectin isoform X2", "gene_name": "Npnt", "gene_names_uniprotkb": "Npnt", "gene_names_refseq": "Npnt", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F5G2", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F5G2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TIRPTYRPTTRPTPNPTPQP", "down_seq": "PPPPPPLPTELKTTPLPPTP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr375", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "371", "end_pos": "371" }, { "start_pos": "375", "end_pos": "375" }, { "start_pos": "394", "end_pos": "394" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "downstream", "id": "A0A9J7F5G2-1.371.371", "categories": [ "glycosylation_flag" ] }, { "distance": 19, "direction": "upstream", "id": "A0A9J7F5G2-1.394.394", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F5G2-1.394.394", "start_pos": 394, "end_pos": 394, "uniprot_canonical_ac": "A0A9J7F5G2-1", "length": 609, "uniprot_id": "A0A9J7F5G2_CRIGR", "protein_name": "Nephronectin", "refseq_ac": "XP_027251534", "refseq_name": "nephronectin isoform X2", "gene_name": "Npnt", "gene_names_uniprotkb": "Npnt", "gene_names_refseq": "Npnt", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F5G2", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F5G2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PTPPPPPPLPTELKTTPLPP", "down_seq": "PERPSSRPTTIAPATSTAAR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr394", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "371", "end_pos": "371" }, { "start_pos": "375", "end_pos": "375" }, { "start_pos": "394", "end_pos": "394" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "A0A9J7F5G2-1.375.375", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F5S4-1.247.247", "start_pos": 247, "end_pos": 247, "uniprot_canonical_ac": "A0A9J7F5S4-1", "length": 693, "uniprot_id": "A0A9J7F5S4_CRIGR", "protein_name": "EF-hand domain-containing protein 1", "refseq_ac": "XP_027248589", "refseq_name": "EF-hand domain-containing protein 1", "gene_name": "Efhc1", "gene_names_uniprotkb": "Efhc1", "gene_names_refseq": "Efhc1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F5S4", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F5S4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EKMPLDPYTELRKEPVRKYI", "down_seq": "PSDFDQLKQFLTFDKQVLRF", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr247", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "247", "end_pos": "247" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F6A0-1.1676.1676", "start_pos": 1676, "end_pos": 1676, "uniprot_canonical_ac": "A0A9J7F6A0-1", "length": 1949, "uniprot_id": "A0A9J7F6A0_CRIGR", "protein_name": "Methylcytosine dioxygenase TET", "refseq_ac": "XP_027251547", "refseq_name": "methylcytosine dioxygenase TET2 isoform X3", "gene_name": "Tet2", "gene_names_uniprotkb": "Tet2", "gene_names_refseq": "Tet2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F6A0", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F6A0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "FSDCTIKPNVHHLATFPPYP", "down_seq": "PGVDGHFMGVTSRLPYSMSN", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1676", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1676", "end_pos": "1676" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HV02-1.49.49", "start_pos": 49, "end_pos": 49, "uniprot_canonical_ac": "G3HV02-1", "length": 302, "uniprot_id": "G3HV02_CRIGR", "protein_name": "alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide6-alpha-sialyltransferase", "refseq_ac": "XP_007645915", "refseq_name": "alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase isoform X1", "gene_name": "St6galnac4", "gene_names_uniprotkb": "St6galnac4", "gene_names_refseq": "St6galnac4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HV02", "url": "https://www.uniprot.org/uniprotkb/G3HV02" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "CLPLCLATCLDPHLPLAPRP", "down_seq": "VPGPLHFSGYSSVPDGKPLI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr49", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "49", "end_pos": "49" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HVT6-1.262.262", "start_pos": 262, "end_pos": 262, "uniprot_canonical_ac": "G3HVT6-1", "length": 308, "uniprot_id": "G3HVT6_CRIGR", "protein_name": "Olfactory receptor", "refseq_ac": "XP_003507447", "refseq_name": "olfactory receptor 12D2", "gene_name": "LOC100768442", "gene_names_uniprotkb": "LOC100768442", "gene_names_refseq": "LOC100768442", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HVT6", "url": "https://www.uniprot.org/uniprotkb/G3HVT6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SHFMVVILFYAPVIFTYIRP", "down_seq": "SGSSLDQDRVIAIMYSVVTP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr262", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "262", "end_pos": "262" }, { "start_pos": "281", "end_pos": "281" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "upstream", "id": "G3HVT6-1.281.281", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HVT6-1.281.281", "start_pos": 281, "end_pos": 281, "uniprot_canonical_ac": "G3HVT6-1", "length": 308, "uniprot_id": "G3HVT6_CRIGR", "protein_name": "Olfactory receptor", "refseq_ac": "XP_003507447", "refseq_name": "olfactory receptor 12D2", "gene_name": "LOC100768442", "gene_names_uniprotkb": "LOC100768442", "gene_names_refseq": "LOC100768442", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HVT6", "url": "https://www.uniprot.org/uniprotkb/G3HVT6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PTSGSSLDQDRVIAIMYSVV", "down_seq": "PALNPLIYTLRNKEVRSALT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr281", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "262", "end_pos": "262" }, { "start_pos": "281", "end_pos": "281" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "G3HVT6-1.262.262", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HVU9-1.106.106", "start_pos": 106, "end_pos": 106, "uniprot_canonical_ac": "G3HVU9-1", "length": 126, "uniprot_id": "G3HVU9_CRIGR", "protein_name": "E3 ubiquitin-protein ligase PPP1R11", "refseq_ac": "XP_003507458", "refseq_name": "E3 ubiquitin-protein ligase PPP1R11", "gene_name": "Ppp1r11", "gene_names_uniprotkb": "Ppp1r11", "gene_names_refseq": "Ppp1r11", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HVU9", "url": "https://www.uniprot.org/uniprotkb/G3HVU9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GHTHCVRGHRKGRRHSTPGP", "down_seq": "PTTPPQPPDPSQPPPGPMQH", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr106", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "106", "end_pos": "106" }, { "start_pos": "108", "end_pos": "108" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "upstream", "id": "G3HVU9-1.108.108", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HVU9-1.108.108", "start_pos": 108, "end_pos": 108, "uniprot_canonical_ac": "G3HVU9-1", "length": 126, "uniprot_id": "G3HVU9_CRIGR", "protein_name": "E3 ubiquitin-protein ligase PPP1R11", "refseq_ac": "XP_003507458", "refseq_name": "E3 ubiquitin-protein ligase PPP1R11", "gene_name": "Ppp1r11", "gene_names_uniprotkb": "Ppp1r11", "gene_names_refseq": "Ppp1r11", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HVU9", "url": "https://www.uniprot.org/uniprotkb/G3HVU9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "THCVRGHRKGRRHSTPGPTP", "down_seq": "TPPQPPDPSQPPPGPMQH", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr108", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "106", "end_pos": "106" }, { "start_pos": "108", "end_pos": "108" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "downstream", "id": "G3HVU9-1.106.106", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HW25-1.12.12", "start_pos": 12, "end_pos": 12, "uniprot_canonical_ac": "G3HW25-1", "length": 397, "uniprot_id": "G3HW25_CRIGR", "protein_name": "G-protein coupled receptor 182", "refseq_ac": "XP_016833655", "refseq_name": "G-protein coupled receptor 182", "gene_name": "Gpr182", "gene_names_uniprotkb": "Gpr182", "gene_names_refseq": "Gpr182", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HW25", "url": "https://www.uniprot.org/uniprotkb/G3HW25" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MSVKSSPGPSP", "down_seq": "SAPGNDFGEIHNWTELLHFF", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr12", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "12", "end_pos": "12" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HW31-1.8.8", "start_pos": 8, "end_pos": 8, "uniprot_canonical_ac": "G3HW31-1", "length": 525, "uniprot_id": "G3HW31_CRIGR", "protein_name": "NGFI-A-binding protein 2 isoform X1", "refseq_ac": "XP_003507534", "refseq_name": "NGFI-A-binding protein 2 isoform X1", "gene_name": "Nab2", "gene_names_uniprotkb": "Nab2", "gene_names_refseq": "Nab2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HW31", "url": "https://www.uniprot.org/uniprotkb/G3HW31" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MHRAPSP", "down_seq": "AEQPPGRGDNTRRTPQPRLK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr8", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "8", "end_pos": "8" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HWF2-1.281.281", "start_pos": 281, "end_pos": 281, "uniprot_canonical_ac": "G3HWF2-1", "length": 723, "uniprot_id": "G3HWF2_CRIGR", "protein_name": "tRNA endonuclease ANKZF1", "refseq_ac": "XP_007646382", "refseq_name": "ankyrin repeat and zinc finger domain-containing protein 1 isoform X1", "gene_name": "Ankzf1", "gene_names_uniprotkb": "Ankzf1", "gene_names_refseq": "Ankzf1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HWF2", "url": "https://www.uniprot.org/uniprotkb/G3HWF2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LRRYNEAMLYKDVRDLLTGP", "down_seq": "WAKALGEAETILLRAPRSGR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr281", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "281", "end_pos": "281" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HWL5-1.8.8", "start_pos": 8, "end_pos": 8, "uniprot_canonical_ac": "G3HWL5-1", "length": 221, "uniprot_id": "G3HWL5_CRIGR", "protein_name": "Vacuolar protein sorting-associated protein 28 homolog", "refseq_ac": "XP_003507704", "refseq_name": "vacuolar protein sorting-associated protein 28 homolog", "gene_name": "Vps28", "gene_names_uniprotkb": "Vps28", "gene_names_refseq": "Vps28", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HWL5", "url": "https://www.uniprot.org/uniprotkb/G3HWL5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MFHGIPA", "down_seq": "PGIGAPGNKPELYEEVKLYK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr8", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "8", "end_pos": "8" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HWQ5-1.146.146", "start_pos": 146, "end_pos": 146, "uniprot_canonical_ac": "G3HWQ5-1", "length": 725, "uniprot_id": "G3HWQ5_CRIGR", "protein_name": "Zinc finger protein 219", "refseq_ac": "XP_027296033", "refseq_name": "zinc finger protein 219 isoform X1", "gene_name": "Znf219", "gene_names_uniprotkb": "Znf219", "gene_names_refseq": "Znf219", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HWQ5", "url": "https://www.uniprot.org/uniprotkb/G3HWQ5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RALLREAQLGRARSSGGMQA", "down_seq": "PATEGLARPQVPSSSAFPCP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr146", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "146", "end_pos": "146" }, { "start_pos": "260", "end_pos": "260" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "367", "end_pos": "367" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HWQ5-1.260.260", "start_pos": 260, "end_pos": 260, "uniprot_canonical_ac": "G3HWQ5-1", "length": 725, "uniprot_id": "G3HWQ5_CRIGR", "protein_name": "Zinc finger protein 219", "refseq_ac": "XP_027296033", "refseq_name": "zinc finger protein 219 isoform X1", "gene_name": "Znf219", "gene_names_uniprotkb": "Znf219", "gene_names_refseq": "Znf219", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HWQ5", "url": "https://www.uniprot.org/uniprotkb/G3HWQ5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EPEPEPEPRPEPEHEANPAP", "down_seq": "PAPPEEPPAPPEFRCQVCGQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr260", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "146", "end_pos": "146" }, { "start_pos": "260", "end_pos": "260" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "367", "end_pos": "367" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HWQ5-1.338.338", "start_pos": 338, "end_pos": 338, "uniprot_canonical_ac": "G3HWQ5-1", "length": 725, "uniprot_id": "G3HWQ5_CRIGR", "protein_name": "Zinc finger protein 219", "refseq_ac": "XP_027296033", "refseq_name": "zinc finger protein 219 isoform X1", "gene_name": "Znf219", "gene_names_uniprotkb": "Znf219", "gene_names_refseq": "Znf219", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HWQ5", "url": "https://www.uniprot.org/uniprotkb/G3HWQ5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "NHMKVHTSKLGPLRAPGPGS", "down_seq": "PARAPQPPDMSLLAYEPLGP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr338", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "146", "end_pos": "146" }, { "start_pos": "260", "end_pos": "260" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "367", "end_pos": "367" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HWQ5-1.367.367", "start_pos": 367, "end_pos": 367, "uniprot_canonical_ac": "G3HWQ5-1", "length": 725, "uniprot_id": "G3HWQ5_CRIGR", "protein_name": "Zinc finger protein 219", "refseq_ac": "XP_027296033", "refseq_name": "zinc finger protein 219 isoform X1", "gene_name": "Znf219", "gene_names_uniprotkb": "Znf219", "gene_names_refseq": "Znf219", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HWQ5", "url": "https://www.uniprot.org/uniprotkb/G3HWQ5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DMSLLAYEPLGPALLLAPAP", "down_seq": "PAERREPPSLLGYLSVRAGE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr367", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "146", "end_pos": "146" }, { "start_pos": "260", "end_pos": "260" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "367", "end_pos": "367" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HXC7-1.223.223", "start_pos": 223, "end_pos": 223, "uniprot_canonical_ac": "G3HXC7-1", "length": 536, "uniprot_id": "G3HXC7_CRIGR", "protein_name": "Protein BHLHb9", "refseq_ac": "XP_035315335", "refseq_name": "protein BHLHb9", "gene_name": "LOC100767015", "gene_names_uniprotkb": "LOC100767015", "gene_names_refseq": "LOC100767015", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HXC7", "url": "https://www.uniprot.org/uniprotkb/G3HXC7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EKNRPKDWSEVTIWPKAPAV", "down_seq": "PAVLGYTSQDSSESRPSSFI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr223", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "223", "end_pos": "223" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HXI5-1.599.599", "start_pos": 599, "end_pos": 599, "uniprot_canonical_ac": "G3HXI5-1", "length": 646, "uniprot_id": "G3HXI5_CRIGR", "protein_name": "Peptidylprolyl isomerase domain and WD repeat-containing protein 1", "refseq_ac": "XP_003507983", "refseq_name": "peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X1", "gene_name": "Ppwd1", "gene_names_uniprotkb": "Ppwd1", "gene_names_refseq": "Ppwd1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HXI5", "url": "https://www.uniprot.org/uniprotkb/G3HXI5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SMANAGSNTNGSQFFITVVP", "down_seq": "PWLDNKHTVFGRVTKGMEVV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr599", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "599", "end_pos": "599" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HXS7-1.611.611", "start_pos": 611, "end_pos": 611, "uniprot_canonical_ac": "G3HXS7-1", "length": 1676, "uniprot_id": "G3HXS7_CRIGR", "protein_name": "E3 ubiquitin-protein ligase SHPRH", "refseq_ac": "XP_027296291", "refseq_name": "E3 ubiquitin-protein ligase SHPRH isoform X1", "gene_name": "Shprh", "gene_names_uniprotkb": "Shprh", "gene_names_refseq": "Shprh", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HXS7", "url": "https://www.uniprot.org/uniprotkb/G3HXS7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "HVPSPAAGDSANTDTNVSES", "down_seq": "PASEDKQNQEAKELVRSPKP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr611", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "611", "end_pos": "611" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HXX7-1.27.27", "start_pos": 27, "end_pos": 27, "uniprot_canonical_ac": "G3HXX7-1", "length": 596, "uniprot_id": "G3HXX7_CRIGR", "protein_name": "Tectonic-3", "refseq_ac": "XP_003508121", "refseq_name": "tectonic-3", "gene_name": "Tctn3", "gene_names_uniprotkb": "Tctn3", "gene_names_refseq": "Tctn3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HXX7", "url": "https://www.uniprot.org/uniprotkb/G3HXX7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "HLLTVLALMLPDAAGPQPSP", "down_seq": "QALPTSSALGPETPEVATAA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr27", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "27", "end_pos": "27" }, { "start_pos": "57", "end_pos": "57" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HXX7-1.57.57", "start_pos": 57, "end_pos": 57, "uniprot_canonical_ac": "G3HXX7-1", "length": 596, "uniprot_id": "G3HXX7_CRIGR", "protein_name": "Tectonic-3", "refseq_ac": "XP_003508121", "refseq_name": "tectonic-3", "gene_name": "Tctn3", "gene_names_uniprotkb": "Tctn3", "gene_names_refseq": "Tctn3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HXX7", "url": "https://www.uniprot.org/uniprotkb/G3HXX7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GPETPEVATAAPPPDWSEGP", "down_seq": "PWTPPMPENVTTDLLPALPI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr57", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "27", "end_pos": "27" }, { "start_pos": "57", "end_pos": "57" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HXY1-1.34.34", "start_pos": 34, "end_pos": 34, "uniprot_canonical_ac": "G3HXY1-1", "length": 329, "uniprot_id": "G3HXY1_CRIGR", "protein_name": "PDZ and LIM domain protein 1", "refseq_ac": "XP_003508114", "refseq_name": "PDZ and LIM domain protein 1", "gene_name": "Pdlim1", "gene_names_uniprotkb": "Pdlim1", "gene_names_refseq": "Pdlim1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HXY1", "url": "https://www.uniprot.org/uniprotkb/G3HXY1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "WGFRLVGGKDFEQPLAISRV", "down_seq": "PGSKAAIANLCIGDLITAID", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr34", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "34", "end_pos": "34" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HY02-1.1050.1050", "start_pos": 1050, "end_pos": 1050, "uniprot_canonical_ac": "G3HY02-1", "length": 2193, "uniprot_id": "G3HY02_CRIGR", "protein_name": "Calcineurin-binding protein cabin-1", "refseq_ac": "XP_007646920", "refseq_name": "calcineurin-binding protein cabin-1 isoform X1", "gene_name": "Cabin1", "gene_names_uniprotkb": "Cabin1", "gene_names_refseq": "Cabin1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HY02", "url": "https://www.uniprot.org/uniprotkb/G3HY02" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SAYIEGTSAEVPCLPDGADP", "down_seq": "PPVVSELYYLLADYHFKNKE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1050", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1050", "end_pos": "1050" }, { "start_pos": "1430", "end_pos": "1430" }, { "start_pos": "1946", "end_pos": "1946" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HY02-1.1430.1430", "start_pos": 1430, "end_pos": 1430, "uniprot_canonical_ac": "G3HY02-1", "length": 2193, "uniprot_id": "G3HY02_CRIGR", "protein_name": "Calcineurin-binding protein cabin-1", "refseq_ac": "XP_007646920", "refseq_name": "calcineurin-binding protein cabin-1 isoform X1", "gene_name": "Cabin1", "gene_names_uniprotkb": "Cabin1", "gene_names_refseq": "Cabin1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HY02", "url": "https://www.uniprot.org/uniprotkb/G3HY02" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "KRLSGLSAQAGPTGKDLPGP", "down_seq": "EERGKTEESLESAEAFRVVE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1430", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1050", "end_pos": "1050" }, { "start_pos": "1430", "end_pos": "1430" }, { "start_pos": "1946", "end_pos": "1946" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HY02-1.1946.1946", "start_pos": 1946, "end_pos": 1946, "uniprot_canonical_ac": "G3HY02-1", "length": 2193, "uniprot_id": "G3HY02_CRIGR", "protein_name": "Calcineurin-binding protein cabin-1", "refseq_ac": "XP_007646920", "refseq_name": "calcineurin-binding protein cabin-1 isoform X1", "gene_name": "Cabin1", "gene_names_uniprotkb": "Cabin1", "gene_names_refseq": "Cabin1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HY02", "url": "https://www.uniprot.org/uniprotkb/G3HY02" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TTPKHPKDSRENFFPATVAP", "down_seq": "APDPLPADALQRPSDSHVKP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1946", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1050", "end_pos": "1050" }, { "start_pos": "1430", "end_pos": "1430" }, { "start_pos": "1946", "end_pos": "1946" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HYU2-1.338.338", "start_pos": 338, "end_pos": 338, "uniprot_canonical_ac": "G3HYU2-1", "length": 382, "uniprot_id": "G3HYU2_CRIGR", "protein_name": "Protein delta homolog 2", "refseq_ac": "XP_016834134", "refseq_name": "protein delta homolog 2 isoform X1", "gene_name": "Dlk2", "gene_names_uniprotkb": "Dlk2", "gene_names_refseq": "Dlk2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HYU2", "url": "https://www.uniprot.org/uniprotkb/G3HYU2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ALVLATVLLTLRAWRRGICP", "down_seq": "GPCCYPAPHYAPARQDQECQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr338", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "338", "end_pos": "338" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HYU7-1.1004.1004", "start_pos": 1004, "end_pos": 1004, "uniprot_canonical_ac": "G3HYU7-1", "length": 1204, "uniprot_id": "G3HYU7_CRIGR", "protein_name": "Exportin-5", "refseq_ac": "XP_003508373", "refseq_name": "exportin-5 isoform X1", "gene_name": "Xpo5", "gene_names_uniprotkb": "Xpo5", "gene_names_refseq": "Xpo5", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HYU7", "url": "https://www.uniprot.org/uniprotkb/G3HYU7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DHSAVPTVDGDDEEMMATEV", "down_seq": "PSSVAELTDLGKCLMKHEDI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1004", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1004", "end_pos": "1004" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3HZ24-1.341.341", "start_pos": 341, "end_pos": 341, "uniprot_canonical_ac": "G3HZ24-1", "length": 497, "uniprot_id": "G3HZ24_CRIGR", "protein_name": "WASH complex subunit 1 isoform X2", "refseq_ac": "XP_027253577", "refseq_name": "WASH complex subunit 1 isoform X2", "gene_name": "Washc1", "gene_names_uniprotkb": "Washc1", "gene_names_refseq": "Washc1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3HZ24", "url": "https://www.uniprot.org/uniprotkb/G3HZ24" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ALLAAPPPPPPPPPPPPPAP", "down_seq": "VVVSAPQPPVFPEVATAPGQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr341", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "341", "end_pos": "341" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3I064-1.204.204", "start_pos": 204, "end_pos": 204, "uniprot_canonical_ac": "G3I064-1", "length": 944, "uniprot_id": "G3I064_CRIGR", "protein_name": "Neutral alpha-glucosidase AB", "refseq_ac": "XP_003508784", "refseq_name": "neutral alpha-glucosidase AB isoform X2", "gene_name": "Ganab", "gene_names_uniprotkb": "Ganab", "gene_names_refseq": "Ganab", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3I064", "url": "https://www.uniprot.org/uniprotkb/G3I064" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PKVPQESKDPAEGNGAQPEA", "down_seq": "PGDGDQPEETQEKAEKDEPG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr204", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "204", "end_pos": "204" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3I099-1.526.526", "start_pos": 526, "end_pos": 526, "uniprot_canonical_ac": "G3I099-1", "length": 774, "uniprot_id": "G3I099_CRIGR", "protein_name": "Chloride channel protein", "refseq_ac": "XP_007647580", "refseq_name": "H(+)/Cl(-) exchange transporter 4 isoform X1", "gene_name": "Clcn4", "gene_names_uniprotkb": "Clcn4", "gene_names_refseq": "Clcn4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3I099", "url": "https://www.uniprot.org/uniprotkb/G3I099" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "YHHHDWIIFRNWCRPGADCV", "down_seq": "PGLYAMVGAAACLGGVTRMT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr526", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "526", "end_pos": "526" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3I0U3-1.358.358", "start_pos": 358, "end_pos": 358, "uniprot_canonical_ac": "G3I0U3-1", "length": 417, "uniprot_id": "G3I0U3_CRIGR", "protein_name": "Mast cell carboxypeptidase A", "refseq_ac": "XP_003508977", "refseq_name": "mast cell carboxypeptidase A", "gene_name": "Cpa3", "gene_names_uniprotkb": "Cpa3", "gene_names_refseq": "Cpa3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3I0U3", "url": "https://www.uniprot.org/uniprotkb/G3I0U3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LSSRYETHYIYGPIASTIYP", "down_seq": "SGSSLDWAYDLGIKHTFAFE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr358", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "358", "end_pos": "358" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3I0W5-1.4.4", "start_pos": 4, "end_pos": 4, "uniprot_canonical_ac": "G3I0W5-1", "length": 464, "uniprot_id": "G3I0W5_CRIGR", "protein_name": "non-specific serine/threonine protein kinase", "refseq_ac": "XP_003508993", "refseq_name": "serine/threonine-protein kinase 38-like isoform X1", "gene_name": "Stk38l", "gene_names_uniprotkb": "Stk38l", "gene_names_refseq": "Stk38l", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3I0W5", "url": "https://www.uniprot.org/uniprotkb/G3I0W5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MAV", "down_seq": "AGAATTFPMSNHTRERVTVA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr4", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "4", "end_pos": "4" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3I108-1.248.248", "start_pos": 248, "end_pos": 248, "uniprot_canonical_ac": "G3I108-1", "length": 492, "uniprot_id": "G3I108_CRIGR", "protein_name": "Fibroblast growth factor receptor substrate 3", "refseq_ac": "XP_027296960", "refseq_name": "fibroblast growth factor receptor substrate 3", "gene_name": "Frs3", "gene_names_uniprotkb": "Frs3", "gene_names_refseq": "Frs3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3I108", "url": "https://www.uniprot.org/uniprotkb/G3I108" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DQRDAQVFLQPGQVKFVLGP", "down_seq": "PARRQVKCQTLCPSMHDPSH", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr248", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "248", "end_pos": "248" }, { "start_pos": "445", "end_pos": "445" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3I108-1.445.445", "start_pos": 445, "end_pos": 445, "uniprot_canonical_ac": "G3I108-1", "length": 492, "uniprot_id": "G3I108_CRIGR", "protein_name": "Fibroblast growth factor receptor substrate 3", "refseq_ac": "XP_027296960", "refseq_name": "fibroblast growth factor receptor substrate 3", "gene_name": "Frs3", "gene_names_uniprotkb": "Frs3", "gene_names_refseq": "Frs3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3I108", "url": "https://www.uniprot.org/uniprotkb/G3I108" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "WGTDRPKGSQNPSVSGAPGP", "down_seq": "PHPVRSSDSYAVIDLKKTVA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr445", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "248", "end_pos": "248" }, { "start_pos": "445", "end_pos": "445" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3I142-1.383.383", "start_pos": 383, "end_pos": 383, "uniprot_canonical_ac": "G3I142-1", "length": 793, "uniprot_id": "G3I142_CRIGR", "protein_name": "Splicing factor 3A subunit 1", "refseq_ac": "XP_003509056", "refseq_name": "splicing factor 3A subunit 1", "gene_name": "Sf3a1", "gene_names_uniprotkb": "Sf3a1", "gene_names_refseq": "Sf3a1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3I142", "url": "https://www.uniprot.org/uniprotkb/G3I142" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EEGQKVPPPPETPMPPPLPP", "down_seq": "PDQVIVRKDYDPKASKPLPP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr383", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "383", "end_pos": "383" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3I1H4-1.218.218", "start_pos": 218, "end_pos": 218, "uniprot_canonical_ac": "G3I1H4-1", "length": 733, "uniprot_id": "G3I1H4_CRIGR", "protein_name": "Golgin subfamily A member 5", "refseq_ac": "XP_003509179", "refseq_name": "golgin subfamily A member 5 isoform X1", "gene_name": "Golga5", "gene_names_uniprotkb": "Golga5", "gene_names_refseq": "Golga5", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3I1H4", "url": "https://www.uniprot.org/uniprotkb/G3I1H4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ESTASNATSTEHSTEPSPAP", "down_seq": "DGGRSHELSNLRLENQLLRN", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr218", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "218", "end_pos": "218" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3I1Q1-1.282.282", "start_pos": 282, "end_pos": 282, "uniprot_canonical_ac": "G3I1Q1-1", "length": 314, "uniprot_id": "G3I1Q1_CRIGR", "protein_name": "Olfactory receptor", "refseq_ac": "XP_003509248", "refseq_name": "olfactory receptor 11H7", "gene_name": "LOC100752760", "gene_names_uniprotkb": "LOC100752760", "gene_names_refseq": "LOC100752760", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3I1Q1", "url": "https://www.uniprot.org/uniprotkb/G3I1Q1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PTSGNSVAMHKIITLIYSVV", "down_seq": "PALNPFIYSLRNKDMKYALR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr282", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "282", "end_pos": "282" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3I244-1.769.769", "start_pos": 769, "end_pos": 769, "uniprot_canonical_ac": "G3I244-1", "length": 1262, "uniprot_id": "G3I244_CRIGR", "protein_name": "Period circadian protein homolog 2", "refseq_ac": "XP_027297185", "refseq_name": "period circadian protein homolog 2 isoform X1", "gene_name": "Per2", "gene_names_uniprotkb": "Per2", "gene_names_refseq": "Per2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3I244", "url": "https://www.uniprot.org/uniprotkb/G3I244" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QARCHSYLQERSRAQASERA", "down_seq": "PGLRNTSGIESSWKKTGKNR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr769", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "769", "end_pos": "769" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3I253-1.1043.1043", "start_pos": 1043, "end_pos": 1043, "uniprot_canonical_ac": "G3I253-1", "length": 1128, "uniprot_id": "G3I253_CRIGR", "protein_name": "Hermansky-Pudlak syndrome 5 protein homolog", "refseq_ac": "XP_016834632", "refseq_name": "Hermansky-Pudlak syndrome 5 protein", "gene_name": "Hps5", "gene_names_uniprotkb": "Hps5", "gene_names_refseq": "Hps5", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3I253", "url": "https://www.uniprot.org/uniprotkb/G3I253" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ETLEEWKLLLHLLQNKSIRP", "down_seq": "PQESLNGSLSDGPAPINVEN", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1043", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1043", "end_pos": "1043" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3I254-1.386.386", "start_pos": 386, "end_pos": 386, "uniprot_canonical_ac": "G3I254-1", "length": 547, "uniprot_id": "G3I254_CRIGR", "protein_name": "General transcription factor IIH subunit 1", "refseq_ac": "XP_003509390", "refseq_name": "general transcription factor IIH subunit 1", "gene_name": "Gtf2h1", "gene_names_uniprotkb": "Gtf2h1", "gene_names_refseq": "Gtf2h1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3I254", "url": "https://www.uniprot.org/uniprotkb/G3I254" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "NSVKTIALNLKKSDRYYHGP", "down_seq": "PIQSLQYATSQDIINSFQSI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr386", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "386", "end_pos": "386" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3I258-1.357.357", "start_pos": 357, "end_pos": 357, "uniprot_canonical_ac": "G3I258-1", "length": 684, "uniprot_id": "G3I258_CRIGR", "protein_name": "Protein SPT2 homolog", "refseq_ac": "XP_003509393", "refseq_name": "protein SPT2 homolog isoform X1", "gene_name": "Spty2d1", "gene_names_uniprotkb": "Spty2d1", "gene_names_refseq": "Spty2d1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3I258", "url": "https://www.uniprot.org/uniprotkb/G3I258" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SEHKAKKPLPSHPSHSKPGP", "down_seq": "VLSHNKAKSPGVRQLGSNSG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr357", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "357", "end_pos": "357" }, { "start_pos": "391", "end_pos": "391" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3I258-1.391.391", "start_pos": 391, "end_pos": 391, "uniprot_canonical_ac": "G3I258-1", "length": 684, "uniprot_id": "G3I258_CRIGR", "protein_name": "Protein SPT2 homolog", "refseq_ac": "XP_003509393", "refseq_name": "protein SPT2 homolog isoform X1", "gene_name": "Spty2d1", "gene_names_uniprotkb": "Spty2d1", "gene_names_refseq": "Spty2d1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3I258", "url": "https://www.uniprot.org/uniprotkb/G3I258" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QLGSNSGSAPGRPSPGTAGP", "down_seq": "VSSGAMPRRQNGSSSTGPEQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr391", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "357", "end_pos": "357" }, { "start_pos": "391", "end_pos": "391" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3I2G2-1.165.165", "start_pos": 165, "end_pos": 165, "uniprot_canonical_ac": "G3I2G2-1", "length": 202, "uniprot_id": "G3I2G2_CRIGR", "protein_name": "Coiled-coil domain-containing protein 85B", "refseq_ac": "XP_003509490", "refseq_name": "coiled-coil domain-containing protein 85B", "gene_name": "Ccdc85b", "gene_names_uniprotkb": "Ccdc85b", "gene_names_refseq": "Ccdc85b", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3I2G2", "url": "https://www.uniprot.org/uniprotkb/G3I2G2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GEEWGPRGGSGGAVGSGAGP", "down_seq": "PELALPPCGPRDLGDGSSST", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr165", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "165", "end_pos": "165" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3I8E9-1.209.209", "start_pos": 209, "end_pos": 209, "uniprot_canonical_ac": "G3I8E9-1", "length": 492, "uniprot_id": "G3I8E9_CRIGR", "protein_name": "Keratin-associated protein 16-1", "refseq_ac": "XP_007650046", "refseq_name": "keratin-associated protein 16-1", "gene_name": "LOC100761497", "gene_names_uniprotkb": "LOC100761497", "gene_names_refseq": "LOC100761497", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3I8E9", "url": "https://www.uniprot.org/uniprotkb/G3I8E9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QPMICEPVVCEPACCQPVCP", "down_seq": "PSCCPSVCSAASSCQPVCCD", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr209", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "209", "end_pos": "209" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3I999-1.72.72", "start_pos": 72, "end_pos": 72, "uniprot_canonical_ac": "G3I999-1", "length": 582, "uniprot_id": "G3I999_CRIGR", "protein_name": "Protein FAM71A", "refseq_ac": "XP_003511627", "refseq_name": "protein FAM71A", "gene_name": "Fam71a", "gene_names_uniprotkb": "Fam71a", "gene_names_refseq": "Fam71a", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3I999", "url": "https://www.uniprot.org/uniprotkb/G3I999" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "FIQITKRGEVIDVHNRVRMV", "down_seq": "VGIACTSPILPLPDVMLLAR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr72", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "72", "end_pos": "72" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3I9I9-1.280.280", "start_pos": 280, "end_pos": 280, "uniprot_canonical_ac": "G3I9I9-1", "length": 312, "uniprot_id": "G3I9I9_CRIGR", "protein_name": "Olfactory receptor 1A1", "refseq_ac": "XP_003511699", "refseq_name": "olfactory receptor 1A1", "gene_name": "LOC100766740", "gene_names_uniprotkb": "LOC100766740", "gene_names_refseq": "LOC100766740", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3I9I9", "url": "https://www.uniprot.org/uniprotkb/G3I9I9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RPLNSYSLKHALITVMYTAV", "down_seq": "PMLNPFIYSLRNRDMKAALR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr280", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "280", "end_pos": "280" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3I9J0-1.280.280", "start_pos": 280, "end_pos": 280, "uniprot_canonical_ac": "G3I9J0-1", "length": 312, "uniprot_id": "G3I9J0_CRIGR", "protein_name": "Olfactory receptor 1A1", "refseq_ac": "XP_003511694", "refseq_name": "olfactory receptor 1A1", "gene_name": "LOC100764996", "gene_names_uniprotkb": "LOC100764996", "gene_names_refseq": "LOC100764996", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3I9J0", "url": "https://www.uniprot.org/uniprotkb/G3I9J0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RPLNSYSLKHALITVMYTAV", "down_seq": "PMLNPFIYSLRNRDMKAALR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr280", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "280", "end_pos": "280" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3I9T6-1.796.796", "start_pos": 796, "end_pos": 796, "uniprot_canonical_ac": "G3I9T6-1", "length": 868, "uniprot_id": "G3I9T6_CRIGR", "protein_name": "Zinc finger protein 629", "refseq_ac": "XP_007650458", "refseq_name": "zinc finger protein 629 isoform X2", "gene_name": "Znf629", "gene_names_uniprotkb": "Znf629", "gene_names_refseq": "Znf629", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3I9T6", "url": "https://www.uniprot.org/uniprotkb/G3I9T6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "FLDRLALTCHQETHTQERAP", "down_seq": "PEDPPSESATLSTNQEDEGE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr796", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "796", "end_pos": "796" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3IA95-1.163.163", "start_pos": 163, "end_pos": 163, "uniprot_canonical_ac": "G3IA95-1", "length": 286, "uniprot_id": "G3IA95_CRIGR", "protein_name": "Homeobox protein TGIF1 isoform X2", "refseq_ac": "XP_003511938", "refseq_name": "homeobox protein TGIF1 isoform X2", "gene_name": "Tgif1", "gene_names_uniprotkb": "Tgif1", "gene_names_refseq": "Tgif1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3IA95", "url": "https://www.uniprot.org/uniprotkb/G3IA95" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "IKNFMPALDERPFHSCTAGP", "down_seq": "QPLGRPASPKPSSPGSILAR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr163", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "163", "end_pos": "163" }, { "start_pos": "253", "end_pos": "253" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3IA95-1.253.253", "start_pos": 253, "end_pos": 253, "uniprot_canonical_ac": "G3IA95-1", "length": 286, "uniprot_id": "G3IA95_CRIGR", "protein_name": "Homeobox protein TGIF1 isoform X2", "refseq_ac": "XP_003511938", "refseq_name": "homeobox protein TGIF1 isoform X2", "gene_name": "Tgif1", "gene_names_uniprotkb": "Tgif1", "gene_names_refseq": "Tgif1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3IA95", "url": "https://www.uniprot.org/uniprotkb/G3IA95" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TCKSGPSPNPQSGLFNTPPP", "down_seq": "PPDLNQDFSGFQLLVDVALK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr253", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "163", "end_pos": "163" }, { "start_pos": "253", "end_pos": "253" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3IAG4-1.682.682", "start_pos": 682, "end_pos": 682, "uniprot_canonical_ac": "G3IAG4-1", "length": 764, "uniprot_id": "G3IAG4_CRIGR", "protein_name": "RNA exonuclease 5", "refseq_ac": "XP_003511993", "refseq_name": "RNA exonuclease 5 isoform X1", "gene_name": "Rexo5", "gene_names_uniprotkb": "Rexo5", "gene_names_refseq": "Rexo5", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3IAG4", "url": "https://www.uniprot.org/uniprotkb/G3IAG4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "HALTPRHLQAWLKDIHPEPA", "down_seq": "PSGLQIVPPLLEKHVFQTLK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr682", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "682", "end_pos": "682" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3IAV7-1.448.448", "start_pos": 448, "end_pos": 448, "uniprot_canonical_ac": "G3IAV7-1", "length": 547, "uniprot_id": "G3IAV7_CRIGR", "protein_name": "Carboxypeptidase N subunit 2", "refseq_ac": "XP_035299991", "refseq_name": "carboxypeptidase N subunit 2", "gene_name": "Cpn2", "gene_names_uniprotkb": "Cpn2", "gene_names_refseq": "Cpn2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3IAV7", "url": "https://www.uniprot.org/uniprotkb/G3IAV7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AYLKGQLVPSLKQEQLVCPV", "down_seq": "PGHLGFLAPGLDDREPGGSW", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr448", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "448", "end_pos": "448" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3IBR2-1.175.175", "start_pos": 175, "end_pos": 175, "uniprot_canonical_ac": "G3IBR2-1", "length": 180, "uniprot_id": "G3IBR2_CRIGR", "protein_name": "Centromere protein M", "refseq_ac": "XP_003512389", "refseq_name": "centromere protein M isoform X1", "gene_name": "Cenpm", "gene_names_uniprotkb": "Cenpm", "gene_names_refseq": "Cenpm", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3IBR2", "url": "https://www.uniprot.org/uniprotkb/G3IBR2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GHVPGISAVNLLSLLRCSDS", "down_seq": "PSKEL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr175", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "175", "end_pos": "175" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3ICE1-1.409.409", "start_pos": 409, "end_pos": 409, "uniprot_canonical_ac": "G3ICE1-1", "length": 1062, "uniprot_id": "G3ICE1_CRIGR", "protein_name": "Pleckstrin homology domain-containing family M member 1", "refseq_ac": "XP_003512588", "refseq_name": "pleckstrin homology domain-containing family M member 1 isoform X1", "gene_name": "Plekhm1", "gene_names_uniprotkb": "Plekhm1", "gene_names_refseq": "Plekhm1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3ICE1", "url": "https://www.uniprot.org/uniprotkb/G3ICE1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AQAAPAGSTSDQQPSGPVGG", "down_seq": "AGQGSGQPKALQYGRIGPKL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr409", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "409", "end_pos": "409" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3ID72-1.286.286", "start_pos": 286, "end_pos": 286, "uniprot_canonical_ac": "G3ID72-1", "length": 311, "uniprot_id": "G3ID72_CRIGR", "protein_name": "JNK1/MAPK8-associated membrane protein isoform X1", "refseq_ac": "XP_003512846", "refseq_name": "JNK1/MAPK8-associated membrane protein isoform X1", "gene_name": "Jkamp", "gene_names_uniprotkb": "Jkamp", "gene_names_refseq": "Jkamp", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3ID72", "url": "https://www.uniprot.org/uniprotkb/G3ID72" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VSISRADRLEHDLPLLALVP", "down_seq": "PALFYLFTAKFTEPSRILSE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr286", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "286", "end_pos": "286" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3IDJ6-1.152.152", "start_pos": 152, "end_pos": 152, "uniprot_canonical_ac": "G3IDJ6-1", "length": 194, "uniprot_id": "G3IDJ6_CRIGR", "protein_name": "Coiled-coil domain-containing protein 184", "refseq_ac": "XP_035295152", "refseq_name": "coiled-coil domain-containing protein 184", "gene_name": "Ccdc184", "gene_names_uniprotkb": "Ccdc184", "gene_names_refseq": "Ccdc184", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3IDJ6", "url": "https://www.uniprot.org/uniprotkb/G3IDJ6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GRDPEEEEDEEEEKAMPSPA", "down_seq": "PTSHRERSESPCAGLLGEDG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr152", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "152", "end_pos": "152" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3IEF3-1.138.138", "start_pos": 138, "end_pos": 138, "uniprot_canonical_ac": "G3IEF3-1", "length": 314, "uniprot_id": "G3IEF3_CRIGR", "protein_name": "Guanine nucleotide exchange factor for Rab-3A isoform X3", "refseq_ac": "XP_027262544", "refseq_name": "guanine nucleotide exchange factor for Rab-3A isoform X3", "gene_name": "Rab3il1", "gene_names_uniprotkb": "Rab3il1", "gene_names_refseq": "Rab3il1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3IEF3", "url": "https://www.uniprot.org/uniprotkb/G3IEF3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RKGHSRHKSTSSSLCPVVCP", "down_seq": "AGHIPTPDKDGKEVDTTLFS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr138", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "138", "end_pos": "138" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3IET4-1.22.22", "start_pos": 22, "end_pos": 22, "uniprot_canonical_ac": "G3IET4-1", "length": 327, "uniprot_id": "G3IET4_CRIGR", "protein_name": "Pseudouridylate synthase TRUB1", "refseq_ac": "XP_003513337", "refseq_name": "probable tRNA pseudouridine synthase 1", "gene_name": "Trub1", "gene_names_uniprotkb": "Trub1", "gene_names_refseq": "Trub1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3IET4", "url": "https://www.uniprot.org/uniprotkb/G3IET4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AVAEAEVVSALTADSAGTAA", "down_seq": "PGAAAAPQAQLSKAALAAKL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr22", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "22", "end_pos": "22" }, { "start_pos": "58", "end_pos": "58" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3IET4-1.58.58", "start_pos": 58, "end_pos": 58, "uniprot_canonical_ac": "G3IET4-1", "length": 327, "uniprot_id": "G3IET4_CRIGR", "protein_name": "Pseudouridylate synthase TRUB1", "refseq_ac": "XP_003513337", "refseq_name": "probable tRNA pseudouridine synthase 1", "gene_name": "Trub1", "gene_names_uniprotkb": "Trub1", "gene_names_refseq": "Trub1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3IET4", "url": "https://www.uniprot.org/uniprotkb/G3IET4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LAAKLLSLSGVFAVHKPKGP", "down_seq": "SAELLNRLKEKLLAEAGMPS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr58", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "22", "end_pos": "22" }, { "start_pos": "58", "end_pos": "58" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3IET5-1.439.439", "start_pos": 439, "end_pos": 439, "uniprot_canonical_ac": "G3IET5-1", "length": 658, "uniprot_id": "G3IET5_CRIGR", "protein_name": "Holliday junction recognition protein isoform X1", "refseq_ac": "XP_007651789", "refseq_name": "Holliday junction recognition protein isoform X1", "gene_name": "Hjurp", "gene_names_uniprotkb": "Hjurp", "gene_names_refseq": "Hjurp", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3IET5", "url": "https://www.uniprot.org/uniprotkb/G3IET5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DKLHQECSLSSEKQLPLAGP", "down_seq": "ESWAVDVYRGTSRSPGSPQG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr439", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "439", "end_pos": "439" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3IF71-1.208.208", "start_pos": 208, "end_pos": 208, "uniprot_canonical_ac": "G3IF71-1", "length": 465, "uniprot_id": "G3IF71_CRIGR", "protein_name": "Tetratricopeptide repeat protein 38", "refseq_ac": "XP_003513462", "refseq_name": "tetratricopeptide repeat protein 38", "gene_name": "Ttc38", "gene_names_uniprotkb": "Ttc38", "gene_names_refseq": "Ttc38", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3IF71", "url": "https://www.uniprot.org/uniprotkb/G3IF71" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ETNFYDQAQKLAKEALSIEP", "down_seq": "DAWSVHTIAHIHEMRAEVKD", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr208", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "208", "end_pos": "208" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3IFF9-1.94.94", "start_pos": 94, "end_pos": 94, "uniprot_canonical_ac": "G3IFF9-1", "length": 165, "uniprot_id": "G3IFF9_CRIGR", "protein_name": "Uncharacterized protein LOC100764507", "refseq_ac": "XP_003513536", "refseq_name": "uncharacterized protein LOC100764507", "gene_name": "LOC100764507", "gene_names_uniprotkb": "LOC100764507", "gene_names_refseq": "LOC100764507", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3IFF9", "url": "https://www.uniprot.org/uniprotkb/G3IFF9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PGQVFWSAQAPTDHTAPAPP", "down_seq": "AADDTMFLGVVPSPDADLTS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr94", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "94", "end_pos": "94" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3IFQ2-1.12.12", "start_pos": 12, "end_pos": 12, "uniprot_canonical_ac": "G3IFQ2-1", "length": 817, "uniprot_id": "G3IFQ2_CRIGR", "protein_name": "General transcription factor 3C polypeptide 4", "refseq_ac": "XP_003513621", "refseq_name": "general transcription factor 3C polypeptide 4", "gene_name": "Gtf3c4", "gene_names_uniprotkb": "Gtf3c4", "gene_names_refseq": "Gtf3c4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3IFQ2", "url": "https://www.uniprot.org/uniprotkb/G3IFQ2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MSEADQAPVGP", "down_seq": "AEEPSPSPEEEGEGGGKEPA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr12", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "12", "end_pos": "12" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3IFX3-1.256.256", "start_pos": 256, "end_pos": 256, "uniprot_canonical_ac": "G3IFX3-1", "length": 510, "uniprot_id": "G3IFX3_CRIGR", "protein_name": "Leucine-rich repeat-containing protein 14B", "refseq_ac": "XP_003513685", "refseq_name": "leucine-rich repeat-containing protein 14B", "gene_name": "Lrrc14b", "gene_names_uniprotkb": "Lrrc14b", "gene_names_refseq": "Lrrc14b", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3IFX3", "url": "https://www.uniprot.org/uniprotkb/G3IFX3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QLTSLTLPTKAFDAPPTCAP", "down_seq": "PEGENPLLNSIAWELSQMNK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr256", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "256", "end_pos": "256" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3IGF1-1.241.241", "start_pos": 241, "end_pos": 241, "uniprot_canonical_ac": "G3IGF1-1", "length": 572, "uniprot_id": "G3IGF1_CRIGR", "protein_name": "Dihydropyrimidinase-related protein 4", "refseq_ac": "XP_003513845", "refseq_name": "dihydropyrimidinase-related protein 4", "gene_name": "Dpysl4", "gene_names_uniprotkb": "Dpysl4", "gene_names_refseq": "Dpysl4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3IGF1", "url": "https://www.uniprot.org/uniprotkb/G3IGF1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EGHVLSHPEEVEAEAVYRAV", "down_seq": "IAKQANCPLYITKVMSKGAA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr241", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "241", "end_pos": "241" }, { "start_pos": "462", "end_pos": "462" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3IGF1-1.462.462", "start_pos": 462, "end_pos": 462, "uniprot_canonical_ac": "G3IGF1-1", "length": 572, "uniprot_id": "G3IGF1_CRIGR", "protein_name": "Dihydropyrimidinase-related protein 4", "refseq_ac": "XP_003513845", "refseq_name": "dihydropyrimidinase-related protein 4", "gene_name": "Dpysl4", "gene_names_uniprotkb": "Dpysl4", "gene_names_refseq": "Dpysl4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3IGF1", "url": "https://www.uniprot.org/uniprotkb/G3IGF1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VPTVVISQGRVVLEDGNLFV", "down_seq": "PGAGRFIPRKTFPDFVYKRI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr462", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "241", "end_pos": "241" }, { "start_pos": "462", "end_pos": "462" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3IH84-1.323.323", "start_pos": 323, "end_pos": 323, "uniprot_canonical_ac": "G3IH84-1", "length": 518, "uniprot_id": "G3IH84_CRIGR", "protein_name": "Arylsulfatase A", "refseq_ac": "XP_003514094", "refseq_name": "arylsulfatase A isoform X1", "gene_name": "Arsa", "gene_names_uniprotkb": "Arsa", "gene_names_refseq": "Arsa", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3IH84", "url": "https://www.uniprot.org/uniprotkb/G3IH84" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GTTFEGGVREPALAFWPGHI", "down_seq": "PGVTHELASSLDLLPTLAAL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr323", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "323", "end_pos": "323" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3IHC8-1.33.33", "start_pos": 33, "end_pos": 33, "uniprot_canonical_ac": "G3IHC8-1", "length": 255, "uniprot_id": "G3IHC8_CRIGR", "protein_name": "Bcl-2-like protein 12 isoform X1", "refseq_ac": "XP_016818884", "refseq_name": "bcl-2-like protein 12 isoform X1", "gene_name": "Bcl2l12", "gene_names_uniprotkb": "Bcl2l12", "gene_names_refseq": "Bcl2l12", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3IHC8", "url": "https://www.uniprot.org/uniprotkb/G3IHC8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TLRVLAAFLRRGEAAGSPVP", "down_seq": "PPRNPAQEEPTDFLSRLRRC", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr33", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "33", "end_pos": "33" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3IKZ3-1.329.329", "start_pos": 329, "end_pos": 329, "uniprot_canonical_ac": "G3IKZ3-1", "length": 356, "uniprot_id": "G3IKZ3_CRIGR", "protein_name": "Transmembrane protein 82", "refseq_ac": "XP_007653324", "refseq_name": "transmembrane protein 82", "gene_name": "Tmem82", "gene_names_uniprotkb": "Tmem82", "gene_names_refseq": "Tmem82", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3IKZ3", "url": "https://www.uniprot.org/uniprotkb/G3IKZ3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "IDLCQIQGFPSQRPTVTAAV", "down_seq": "PGRVSTLTDPCEPRSSAPAL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr329", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "329", "end_pos": "329" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3ILJ1-1.282.282", "start_pos": 282, "end_pos": 282, "uniprot_canonical_ac": "G3ILJ1-1", "length": 307, "uniprot_id": "G3ILJ1_CRIGR", "protein_name": "Olfactory receptor 2AG2", "refseq_ac": "XP_027260794", "refseq_name": "olfactory receptor 2AG2", "gene_name": "LOC100763647", "gene_names_uniprotkb": "LOC100763647", "gene_names_refseq": "LOC100763647", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3ILJ1", "url": "https://www.uniprot.org/uniprotkb/G3ILJ1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PSSFHTPKQDNIFSVFYTIV", "down_seq": "PALNPLIYSLRNKEVTGALR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr282", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "282", "end_pos": "282" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3ILJ2-1.282.282", "start_pos": 282, "end_pos": 282, "uniprot_canonical_ac": "G3ILJ2-1", "length": 316, "uniprot_id": "G3ILJ2_CRIGR", "protein_name": "Olfactory receptor 2AG2", "refseq_ac": "XP_003515315", "refseq_name": "olfactory receptor 2AG2", "gene_name": "LOC100763934", "gene_names_uniprotkb": "LOC100763934", "gene_names_refseq": "LOC100763934", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3ILJ2", "url": "https://www.uniprot.org/uniprotkb/G3ILJ2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PSSFHSPKQDNIISVFYTIV", "down_seq": "PALNPLIYSLRNKEVIGAFR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr282", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "282", "end_pos": "282" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3ILY5-1.282.282", "start_pos": 282, "end_pos": 282, "uniprot_canonical_ac": "G3ILY5-1", "length": 316, "uniprot_id": "G3ILY5_CRIGR", "protein_name": "Olfactory receptor 2AG1", "refseq_ac": "XP_007605779", "refseq_name": "olfactory receptor 2AG1", "gene_name": "LOC100766198", "gene_names_uniprotkb": "LOC100766198", "gene_names_refseq": "LOC100766198", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3ILY5", "url": "https://www.uniprot.org/uniprotkb/G3ILY5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PSQFHSPKQDNVLSVFYTIV", "down_seq": "PALNPLIYSLRNKEVTGALR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr282", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "282", "end_pos": "282" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3INK9-1.282.282", "start_pos": 282, "end_pos": 282, "uniprot_canonical_ac": "G3INK9-1", "length": 315, "uniprot_id": "G3INK9_CRIGR", "protein_name": "Olfactory receptor 2AG1", "refseq_ac": "XP_003515847", "refseq_name": "olfactory receptor 2AG1", "gene_name": "LOC100751431", "gene_names_uniprotkb": "LOC100751431", "gene_names_refseq": "LOC100751431", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3INK9", "url": "https://www.uniprot.org/uniprotkb/G3INK9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PSPFHSPKQDNISSVFYTIV", "down_seq": "PALNPLIYSLRNKEVTGALK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr282", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "282", "end_pos": "282" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3IPA7-1.186.186", "start_pos": 186, "end_pos": 186, "uniprot_canonical_ac": "G3IPA7-1", "length": 525, "uniprot_id": "G3IPA7_CRIGR", "protein_name": "Uncharacterized protein CXorf49 homolog", "refseq_ac": "XP_003516010", "refseq_name": "uncharacterized protein CXorf49 homolog", "gene_name": "LOC100765409", "gene_names_uniprotkb": "LOC100765409", "gene_names_refseq": "LOC100765409", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3IPA7", "url": "https://www.uniprot.org/uniprotkb/G3IPA7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "KSASATSLFPKGLEHSRAWV", "down_seq": "PRKNPAGRGVMGEDPHLSIP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr186", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "186", "end_pos": "186" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GRK9-1.920.920", "start_pos": 920, "end_pos": 920, "uniprot_canonical_ac": "G3GRK9-1", "length": 1459, "uniprot_id": "G3GRK9_CRIGR", "protein_name": "DNA-binding protein RFX7 isoform X1", "refseq_ac": "XP_003495077", "refseq_name": "DNA-binding protein RFX7 isoform X1", "gene_name": "Rfx7", "gene_names_uniprotkb": "Rfx7", "gene_names_refseq": "Rfx7", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GRK9", "url": "https://www.uniprot.org/uniprotkb/G3GRK9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MNNSHSYGNCLGMSLQSQSV", "down_seq": "PGAPMSSHASSAHFYHPIHS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr920", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "920", "end_pos": "920" }, { "start_pos": "951", "end_pos": "951" }, { "start_pos": "953", "end_pos": "953" }, { "start_pos": "955", "end_pos": "955" }, { "start_pos": "957", "end_pos": "957" }, { "start_pos": "959", "end_pos": "959" }, { "start_pos": "961", "end_pos": "961" }, { "start_pos": "963", "end_pos": "963" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GRK9-1.951.951", "start_pos": 951, "end_pos": 951, "uniprot_canonical_ac": "G3GRK9-1", "length": 1459, "uniprot_id": "G3GRK9_CRIGR", "protein_name": "DNA-binding protein RFX7 isoform X1", "refseq_ac": "XP_003495077", "refseq_name": "DNA-binding protein RFX7 isoform X1", "gene_name": "Rfx7", "gene_names_uniprotkb": "Rfx7", "gene_names_refseq": "Rfx7", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GRK9", "url": "https://www.uniprot.org/uniprotkb/G3GRK9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SAHFYHPIHSNGTPIHTPTP", "down_seq": "PTPTPTPTPTPTPTSEMIAG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr951", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "920", "end_pos": "920" }, { "start_pos": "951", "end_pos": "951" }, { "start_pos": "953", "end_pos": "953" }, { "start_pos": "955", "end_pos": "955" }, { "start_pos": "957", "end_pos": "957" }, { "start_pos": "959", "end_pos": "959" }, { "start_pos": "961", "end_pos": "961" }, { "start_pos": "963", "end_pos": "963" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "upstream", "id": "G3GRK9-1.953.953", "categories": [ "glycosylation_flag" ] }, { "distance": 4, "direction": "upstream", "id": "G3GRK9-1.955.955", "categories": [ "glycosylation_flag" ] }, { "distance": 6, "direction": "upstream", "id": "G3GRK9-1.957.957", "categories": [ "glycosylation_flag" ] }, { "distance": 8, "direction": "upstream", "id": "G3GRK9-1.959.959", "categories": [ "glycosylation_flag" ] }, { "distance": 10, "direction": "upstream", "id": "G3GRK9-1.961.961", "categories": [ "glycosylation_flag" ] }, { "distance": 12, "direction": "upstream", "id": "G3GRK9-1.963.963", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GRK9-1.953.953", "start_pos": 953, "end_pos": 953, "uniprot_canonical_ac": "G3GRK9-1", "length": 1459, "uniprot_id": "G3GRK9_CRIGR", "protein_name": "DNA-binding protein RFX7 isoform X1", "refseq_ac": "XP_003495077", "refseq_name": "DNA-binding protein RFX7 isoform X1", "gene_name": "Rfx7", "gene_names_uniprotkb": "Rfx7", "gene_names_refseq": "Rfx7", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GRK9", "url": "https://www.uniprot.org/uniprotkb/G3GRK9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "HFYHPIHSNGTPIHTPTPTP", "down_seq": "PTPTPTPTPTPTSEMIAGSQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr953", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "920", "end_pos": "920" }, { "start_pos": "951", "end_pos": "951" }, { "start_pos": "953", "end_pos": "953" }, { "start_pos": "955", "end_pos": "955" }, { "start_pos": "957", "end_pos": "957" }, { "start_pos": "959", "end_pos": "959" }, { "start_pos": "961", "end_pos": "961" }, { "start_pos": "963", "end_pos": "963" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "downstream", "id": "G3GRK9-1.951.951", "categories": [ "glycosylation_flag" ] }, { "distance": 2, "direction": "upstream", "id": "G3GRK9-1.955.955", "categories": [ "glycosylation_flag" ] }, { "distance": 4, "direction": "upstream", "id": "G3GRK9-1.957.957", "categories": [ "glycosylation_flag" ] }, { "distance": 6, "direction": "upstream", "id": "G3GRK9-1.959.959", "categories": [ "glycosylation_flag" ] }, { "distance": 8, "direction": "upstream", "id": "G3GRK9-1.961.961", "categories": [ "glycosylation_flag" ] }, { "distance": 10, "direction": "upstream", "id": "G3GRK9-1.963.963", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GRK9-1.955.955", "start_pos": 955, "end_pos": 955, "uniprot_canonical_ac": "G3GRK9-1", "length": 1459, "uniprot_id": "G3GRK9_CRIGR", "protein_name": "DNA-binding protein RFX7 isoform X1", "refseq_ac": "XP_003495077", "refseq_name": "DNA-binding protein RFX7 isoform X1", "gene_name": "Rfx7", "gene_names_uniprotkb": "Rfx7", "gene_names_refseq": "Rfx7", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GRK9", "url": "https://www.uniprot.org/uniprotkb/G3GRK9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "YHPIHSNGTPIHTPTPTPTP", "down_seq": "PTPTPTPTPTSEMIAGSQSL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr955", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "920", "end_pos": "920" }, { "start_pos": "951", "end_pos": "951" }, { "start_pos": "953", "end_pos": "953" }, { "start_pos": "955", "end_pos": "955" }, { "start_pos": "957", "end_pos": "957" }, { "start_pos": "959", "end_pos": "959" }, { "start_pos": "961", "end_pos": "961" }, { "start_pos": "963", "end_pos": "963" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "downstream", "id": "G3GRK9-1.951.951", "categories": [ "glycosylation_flag" ] }, { "distance": 2, "direction": "downstream", "id": "G3GRK9-1.953.953", "categories": [ "glycosylation_flag" ] }, { "distance": 2, "direction": "upstream", "id": "G3GRK9-1.957.957", "categories": [ "glycosylation_flag" ] }, { "distance": 4, "direction": "upstream", "id": "G3GRK9-1.959.959", "categories": [ "glycosylation_flag" ] }, { "distance": 6, "direction": "upstream", "id": "G3GRK9-1.961.961", "categories": [ "glycosylation_flag" ] }, { "distance": 8, "direction": "upstream", "id": "G3GRK9-1.963.963", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GRK9-1.957.957", "start_pos": 957, "end_pos": 957, "uniprot_canonical_ac": "G3GRK9-1", "length": 1459, "uniprot_id": "G3GRK9_CRIGR", "protein_name": "DNA-binding protein RFX7 isoform X1", "refseq_ac": "XP_003495077", "refseq_name": "DNA-binding protein RFX7 isoform X1", "gene_name": "Rfx7", "gene_names_uniprotkb": "Rfx7", "gene_names_refseq": "Rfx7", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GRK9", "url": "https://www.uniprot.org/uniprotkb/G3GRK9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PIHSNGTPIHTPTPTPTPTP", "down_seq": "PTPTPTPTSEMIAGSQSLSR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr957", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "920", "end_pos": "920" }, { "start_pos": "951", "end_pos": "951" }, { "start_pos": "953", "end_pos": "953" }, { "start_pos": "955", "end_pos": "955" }, { "start_pos": "957", "end_pos": "957" }, { "start_pos": "959", "end_pos": "959" }, { "start_pos": "961", "end_pos": "961" }, { "start_pos": "963", "end_pos": "963" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 6, "direction": "downstream", "id": "G3GRK9-1.951.951", "categories": [ "glycosylation_flag" ] }, { "distance": 4, "direction": "downstream", "id": "G3GRK9-1.953.953", "categories": [ "glycosylation_flag" ] }, { "distance": 2, "direction": "downstream", "id": "G3GRK9-1.955.955", "categories": [ "glycosylation_flag" ] }, { "distance": 2, "direction": "upstream", "id": "G3GRK9-1.959.959", "categories": [ "glycosylation_flag" ] }, { "distance": 4, "direction": "upstream", "id": "G3GRK9-1.961.961", "categories": [ "glycosylation_flag" ] }, { "distance": 6, "direction": "upstream", "id": "G3GRK9-1.963.963", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GRK9-1.959.959", "start_pos": 959, "end_pos": 959, "uniprot_canonical_ac": "G3GRK9-1", "length": 1459, "uniprot_id": "G3GRK9_CRIGR", "protein_name": "DNA-binding protein RFX7 isoform X1", "refseq_ac": "XP_003495077", "refseq_name": "DNA-binding protein RFX7 isoform X1", "gene_name": "Rfx7", "gene_names_uniprotkb": "Rfx7", "gene_names_refseq": "Rfx7", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GRK9", "url": "https://www.uniprot.org/uniprotkb/G3GRK9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "HSNGTPIHTPTPTPTPTPTP", "down_seq": "PTPTPTSEMIAGSQSLSRES", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr959", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "920", "end_pos": "920" }, { "start_pos": "951", "end_pos": "951" }, { "start_pos": "953", "end_pos": "953" }, { "start_pos": "955", "end_pos": "955" }, { "start_pos": "957", "end_pos": "957" }, { "start_pos": "959", "end_pos": "959" }, { "start_pos": "961", "end_pos": "961" }, { "start_pos": "963", "end_pos": "963" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 8, "direction": "downstream", "id": "G3GRK9-1.951.951", "categories": [ "glycosylation_flag" ] }, { "distance": 6, "direction": "downstream", "id": "G3GRK9-1.953.953", "categories": [ "glycosylation_flag" ] }, { "distance": 4, "direction": "downstream", "id": "G3GRK9-1.955.955", "categories": [ "glycosylation_flag" ] }, { "distance": 2, "direction": "downstream", "id": "G3GRK9-1.957.957", "categories": [ "glycosylation_flag" ] }, { "distance": 2, "direction": "upstream", "id": "G3GRK9-1.961.961", "categories": [ "glycosylation_flag" ] }, { "distance": 4, "direction": "upstream", "id": "G3GRK9-1.963.963", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GRK9-1.961.961", "start_pos": 961, "end_pos": 961, "uniprot_canonical_ac": "G3GRK9-1", "length": 1459, "uniprot_id": "G3GRK9_CRIGR", "protein_name": "DNA-binding protein RFX7 isoform X1", "refseq_ac": "XP_003495077", "refseq_name": "DNA-binding protein RFX7 isoform X1", "gene_name": "Rfx7", "gene_names_uniprotkb": "Rfx7", "gene_names_refseq": "Rfx7", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GRK9", "url": "https://www.uniprot.org/uniprotkb/G3GRK9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "NGTPIHTPTPTPTPTPTPTP", "down_seq": "PTPTSEMIAGSQSLSRESPC", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr961", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "920", "end_pos": "920" }, { "start_pos": "951", "end_pos": "951" }, { "start_pos": "953", "end_pos": "953" }, { "start_pos": "955", "end_pos": "955" }, { "start_pos": "957", "end_pos": "957" }, { "start_pos": "959", "end_pos": "959" }, { "start_pos": "961", "end_pos": "961" }, { "start_pos": "963", "end_pos": "963" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 10, "direction": "downstream", "id": "G3GRK9-1.951.951", "categories": [ "glycosylation_flag" ] }, { "distance": 8, "direction": "downstream", "id": "G3GRK9-1.953.953", "categories": [ "glycosylation_flag" ] }, { "distance": 6, "direction": "downstream", "id": "G3GRK9-1.955.955", "categories": [ "glycosylation_flag" ] }, { "distance": 4, "direction": "downstream", "id": "G3GRK9-1.957.957", "categories": [ "glycosylation_flag" ] }, { "distance": 2, "direction": "downstream", "id": "G3GRK9-1.959.959", "categories": [ "glycosylation_flag" ] }, { "distance": 2, "direction": "upstream", "id": "G3GRK9-1.963.963", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GRK9-1.963.963", "start_pos": 963, "end_pos": 963, "uniprot_canonical_ac": "G3GRK9-1", "length": 1459, "uniprot_id": "G3GRK9_CRIGR", "protein_name": "DNA-binding protein RFX7 isoform X1", "refseq_ac": "XP_003495077", "refseq_name": "DNA-binding protein RFX7 isoform X1", "gene_name": "Rfx7", "gene_names_uniprotkb": "Rfx7", "gene_names_refseq": "Rfx7", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GRK9", "url": "https://www.uniprot.org/uniprotkb/G3GRK9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TPIHTPTPTPTPTPTPTPTP", "down_seq": "PTSEMIAGSQSLSRESPCSR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr963", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "920", "end_pos": "920" }, { "start_pos": "951", "end_pos": "951" }, { "start_pos": "953", "end_pos": "953" }, { "start_pos": "955", "end_pos": "955" }, { "start_pos": "957", "end_pos": "957" }, { "start_pos": "959", "end_pos": "959" }, { "start_pos": "961", "end_pos": "961" }, { "start_pos": "963", "end_pos": "963" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 12, "direction": "downstream", "id": "G3GRK9-1.951.951", "categories": [ "glycosylation_flag" ] }, { "distance": 10, "direction": "downstream", "id": "G3GRK9-1.953.953", "categories": [ "glycosylation_flag" ] }, { "distance": 8, "direction": "downstream", "id": "G3GRK9-1.955.955", "categories": [ "glycosylation_flag" ] }, { "distance": 6, "direction": "downstream", "id": "G3GRK9-1.957.957", "categories": [ "glycosylation_flag" ] }, { "distance": 4, "direction": "downstream", "id": "G3GRK9-1.959.959", "categories": [ "glycosylation_flag" ] }, { "distance": 2, "direction": "downstream", "id": "G3GRK9-1.961.961", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GSP8-1.284.284", "start_pos": 284, "end_pos": 284, "uniprot_canonical_ac": "G3GSP8-1", "length": 307, "uniprot_id": "G3GSP8_CRIGR", "protein_name": "Vesicle-trafficking protein SEC22a", "refseq_ac": "XP_003495466", "refseq_name": "vesicle-trafficking protein SEC22a", "gene_name": "Sec22a", "gene_names_uniprotkb": "Sec22a", "gene_names_refseq": "Sec22a", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GSP8", "url": "https://www.uniprot.org/uniprotkb/G3GSP8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "CLCNMYLYELRNLWQLFFHV", "down_seq": "VGAFVTLQIWLRQAQGKAPD", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr284", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "284", "end_pos": "284" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GTG2-1.620.620", "start_pos": 620, "end_pos": 620, "uniprot_canonical_ac": "G3GTG2-1", "length": 761, "uniprot_id": "G3GTG2_CRIGR", "protein_name": "Protein HID1 isoform X3", "refseq_ac": "XP_035303829", "refseq_name": "protein HID1 isoform X3", "gene_name": "Hid1", "gene_names_uniprotkb": "Hid1", "gene_names_refseq": "Hid1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GTG2", "url": "https://www.uniprot.org/uniprotkb/G3GTG2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EGSRPAAPAEPGTLKTSLVA", "down_seq": "PGIDKLTEKSQVSEDGTLRS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr620", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "620", "end_pos": "620" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GUA9-1.4.4", "start_pos": 4, "end_pos": 4, "uniprot_canonical_ac": "G3GUA9-1", "length": 519, "uniprot_id": "G3GUA9_CRIGR", "protein_name": "DDB1- and CUL4-associated factor 17 isoform X1", "refseq_ac": "XP_003495998", "refseq_name": "DDB1- and CUL4-associated factor 17 isoform X1", "gene_name": "Dcaf17", "gene_names_uniprotkb": "Dcaf17", "gene_names_refseq": "Dcaf17", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GUA9", "url": "https://www.uniprot.org/uniprotkb/G3GUA9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MGP", "down_seq": "PKANVCRRLSRRALGFFARD", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr4", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "4", "end_pos": "4" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GUE1-1.1175.1175", "start_pos": 1175, "end_pos": 1175, "uniprot_canonical_ac": "G3GUE1-1", "length": 1546, "uniprot_id": "G3GUE1_CRIGR", "protein_name": "Protein FAM135A isoform X1", "refseq_ac": "XP_007643999", "refseq_name": "protein FAM135A isoform X1", "gene_name": "Fam135a", "gene_names_uniprotkb": "Fam135a", "gene_names_refseq": "Fam135a", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GUE1", "url": "https://www.uniprot.org/uniprotkb/G3GUE1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "REDRHTQSEKVNSEYLRAAV", "down_seq": "VPAVCTSGCLSFPSAPRESP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1175", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1175", "end_pos": "1175" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GUP6-1.10.10", "start_pos": 10, "end_pos": 10, "uniprot_canonical_ac": "G3GUP6-1", "length": 270, "uniprot_id": "G3GUP6_CRIGR", "protein_name": "Cell division cycle-associated protein 3 isoform X1", "refseq_ac": "XP_003496110", "refseq_name": "cell division cycle-associated protein 3 isoform X1", "gene_name": "Cdca3", "gene_names_uniprotkb": "Cdca3", "gene_names_refseq": "Cdca3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GUP6", "url": "https://www.uniprot.org/uniprotkb/G3GUP6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MGSTQSISG", "down_seq": "PARPLPHNKHLARVADPRSP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr10", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "10", "end_pos": "10" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GVY1-1.52.52", "start_pos": 52, "end_pos": 52, "uniprot_canonical_ac": "G3GVY1-1", "length": 154, "uniprot_id": "G3GVY1_CRIGR", "protein_name": "RING finger protein 11", "refseq_ac": "XP_003496536", "refseq_name": "RING finger protein 11", "gene_name": "Rnf11", "gene_names_uniprotkb": "Rnf11", "gene_names_refseq": "Rnf11", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GVY1", "url": "https://www.uniprot.org/uniprotkb/G3GVY1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PDQEPPPPYQEQVPVPVYHP", "down_seq": "PSQTRLATQLTEEEQIRIAQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr52", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "52", "end_pos": "52" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GW31-1.252.252", "start_pos": 252, "end_pos": 252, "uniprot_canonical_ac": "G3GW31-1", "length": 370, "uniprot_id": "G3GW31_CRIGR", "protein_name": "Probable G-protein coupled receptor 85", "refseq_ac": "XP_007649144", "refseq_name": "probable G-protein coupled receptor 85", "gene_name": "Gpr85", "gene_names_uniprotkb": "Gpr85", "gene_names_refseq": "Gpr85", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GW31", "url": "https://www.uniprot.org/uniprotkb/G3GW31" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GPGASGQAAANWLAGFGRGP", "down_seq": "PPTLLGIRQNANTTGRRRLL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr252", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "252", "end_pos": "252" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GX87-1.620.620", "start_pos": 620, "end_pos": 620, "uniprot_canonical_ac": "G3GX87-1", "length": 648, "uniprot_id": "G3GX87_CRIGR", "protein_name": "Myotubularin-related protein 14 isoform X1", "refseq_ac": "XP_003496898", "refseq_name": "myotubularin-related protein 14 isoform X1", "gene_name": "Mtmr14", "gene_names_uniprotkb": "Mtmr14", "gene_names_refseq": "Mtmr14", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GX87", "url": "https://www.uniprot.org/uniprotkb/G3GX87" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QEVRSAFLAAYSSTVGLRAV", "down_seq": "PSPSGAIGGLLEQFARGVGL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr620", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "620", "end_pos": "620" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GXH5-1.155.155", "start_pos": 155, "end_pos": 155, "uniprot_canonical_ac": "G3GXH5-1", "length": 1581, "uniprot_id": "G3GXH5_CRIGR", "protein_name": "Sterile alpha motif domain-containing protein 9", "refseq_ac": "XP_027241833", "refseq_name": "sterile alpha motif domain-containing protein 9", "gene_name": "Samd9", "gene_names_uniprotkb": "Samd9", "gene_names_refseq": "Samd9", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GXH5", "url": "https://www.uniprot.org/uniprotkb/G3GXH5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "KNELMEDKTELQGKQSPPGP", "down_seq": "CIAYPFNEFSNPYRYKLHFI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr155", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "155", "end_pos": "155" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GXW3-1.186.186", "start_pos": 186, "end_pos": 186, "uniprot_canonical_ac": "G3GXW3-1", "length": 237, "uniprot_id": "G3GXW3_CRIGR", "protein_name": "Homeobox protein TGIF2", "refseq_ac": "XP_035294650", "refseq_name": "homeobox protein TGIF2", "gene_name": "Tgif2", "gene_names_uniprotkb": "Tgif2", "gene_names_refseq": "Tgif2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GXW3", "url": "https://www.uniprot.org/uniprotkb/G3GXW3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LLTRAEAGSPTGGLFNTPPP", "down_seq": "PPEQDKEDFSSFQLLVEVAL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr186", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "186", "end_pos": "186" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GYI7-1.267.267", "start_pos": 267, "end_pos": 267, "uniprot_canonical_ac": "G3GYI7-1", "length": 1300, "uniprot_id": "G3GYI7_CRIGR", "protein_name": "Activating molecule in BECN1-regulated autophagy protein 1", "refseq_ac": "XP_027246360", "refseq_name": "activating molecule in BECN1-regulated autophagy protein 1 isoform X1", "gene_name": "Ambra1", "gene_names_uniprotkb": "Ambra1", "gene_names_refseq": "Ambra1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GYI7", "url": "https://www.uniprot.org/uniprotkb/G3GYI7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LSSRSSGIQVGEQSTVQDSA", "down_seq": "PSPPPPPPQPSTERPRTSAY", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr267", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "267", "end_pos": "267" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GYL2-1.503.503", "start_pos": 503, "end_pos": 503, "uniprot_canonical_ac": "G3GYL2-1", "length": 518, "uniprot_id": "G3GYL2_CRIGR", "protein_name": "Kelch repeat and BTB domain-containing protein 4 isoform X3", "refseq_ac": "XP_003497372", "refseq_name": "kelch repeat and BTB domain-containing protein 4 isoform X3", "gene_name": "Kbtbd4", "gene_names_uniprotkb": "Kbtbd4", "gene_names_refseq": "Kbtbd4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GYL2", "url": "https://www.uniprot.org/uniprotkb/G3GYL2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "YKKGDANTYKLDPATSAVTV", "down_seq": "RGIKVLLTNLQFVLA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr503", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "503", "end_pos": "503" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GYX4-1.414.414", "start_pos": 414, "end_pos": 414, "uniprot_canonical_ac": "G3GYX4-1", "length": 717, "uniprot_id": "G3GYX4_CRIGR", "protein_name": "Cleavage stimulation factor subunit 3", "refseq_ac": "XP_016821390", "refseq_name": "cleavage stimulation factor subunit 3", "gene_name": "Cstf3", "gene_names_uniprotkb": "Cstf3", "gene_names_refseq": "Cstf3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GYX4", "url": "https://www.uniprot.org/uniprotkb/G3GYX4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GRMIFKKAREDARTRHHVYV", "down_seq": "AALMEYYCSKDKSVAFKIFE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr414", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "414", "end_pos": "414" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GZP3-1.519.519", "start_pos": 519, "end_pos": 519, "uniprot_canonical_ac": "G3GZP3-1", "length": 709, "uniprot_id": "G3GZP3_CRIGR", "protein_name": "WD repeat and coiled-coil-containing protein", "refseq_ac": "XP_035298448", "refseq_name": "WD repeat and coiled-coil-containing protein", "gene_name": "Wdcp", "gene_names_uniprotkb": "Wdcp", "gene_names_refseq": "Wdcp", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GZP3", "url": "https://www.uniprot.org/uniprotkb/G3GZP3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SASIVQETPHGPSWLQPALP", "down_seq": "PSGTPDHTSTPEPNLLQREN", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr519", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "519", "end_pos": "519" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3GZX3-1.142.142", "start_pos": 142, "end_pos": 142, "uniprot_canonical_ac": "G3GZX3-1", "length": 227, "uniprot_id": "G3GZX3_CRIGR", "protein_name": "Ubiquitin domain-containing protein 1 isoform X1", "refseq_ac": "XP_003497803", "refseq_name": "ubiquitin domain-containing protein 1 isoform X1", "gene_name": "Ubtd1", "gene_names_uniprotkb": "Ubtd1", "gene_names_refseq": "Ubtd1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3GZX3", "url": "https://www.uniprot.org/uniprotkb/G3GZX3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PPVNLLLEHTEEESLEPPEP", "down_seq": "PSVRREFPLKVRLSTGKDVR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr142", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "142", "end_pos": "142" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H1M0-1.1152.1152", "start_pos": 1152, "end_pos": 1152, "uniprot_canonical_ac": "G3H1M0-1", "length": 1355, "uniprot_id": "G3H1M0_CRIGR", "protein_name": "Pleckstrin homology domain-containing family H member 1 isoform X1", "refseq_ac": "XP_003498316", "refseq_name": "pleckstrin homology domain-containing family H member 1 isoform X1", "gene_name": "Plekhh1", "gene_names_uniprotkb": "Plekhh1", "gene_names_refseq": "Plekhh1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H1M0", "url": "https://www.uniprot.org/uniprotkb/G3H1M0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LMAQVEYGDLEKPVLPGPGG", "down_seq": "PPAKAQHLLQQILDRFYPKR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1152", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1152", "end_pos": "1152" }, { "start_pos": "410", "end_pos": "410" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H1M0-1.410.410", "start_pos": 410, "end_pos": 410, "uniprot_canonical_ac": "G3H1M0-1", "length": 1355, "uniprot_id": "G3H1M0_CRIGR", "protein_name": "Pleckstrin homology domain-containing family H member 1 isoform X1", "refseq_ac": "XP_003498316", "refseq_name": "pleckstrin homology domain-containing family H member 1 isoform X1", "gene_name": "Plekhh1", "gene_names_uniprotkb": "Plekhh1", "gene_names_refseq": "Plekhh1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H1M0", "url": "https://www.uniprot.org/uniprotkb/G3H1M0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ESLKPPRAALEEVELEKKPP", "down_seq": "PPLHRFPSWESRIYAMATSG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr410", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1152", "end_pos": "1152" }, { "start_pos": "410", "end_pos": "410" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H1Q8-1.69.69", "start_pos": 69, "end_pos": 69, "uniprot_canonical_ac": "G3H1Q8-1", "length": 564, "uniprot_id": "G3H1Q8_CRIGR", "protein_name": "Protein FAM178B isoform X2", "refseq_ac": "XP_007623895", "refseq_name": "protein FAM178B isoform X2", "gene_name": "Fam178b", "gene_names_uniprotkb": "Fam178b", "gene_names_refseq": "Fam178b", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H1Q8", "url": "https://www.uniprot.org/uniprotkb/G3H1Q8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GLTSLEELFWNMAGPSQQAV", "down_seq": "PKVSYGGSECYVNNLDYLLQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr69", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "69", "end_pos": "69" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H1R9-1.791.791", "start_pos": 791, "end_pos": 791, "uniprot_canonical_ac": "G3H1R9-1", "length": 877, "uniprot_id": "G3H1R9_CRIGR", "protein_name": "KAT8 regulatory NSL complex subunit 3", "refseq_ac": "XP_007624010", "refseq_name": "KAT8 regulatory NSL complex subunit 3 isoform X2", "gene_name": "Kansl3", "gene_names_uniprotkb": "Kansl3", "gene_names_refseq": "Kansl3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H1R9", "url": "https://www.uniprot.org/uniprotkb/G3H1R9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GTSTIVRTIPVATTLSSLGA", "down_seq": "PGGKPTAIHQLLTNGGLAKL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr791", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "791", "end_pos": "791" }, { "start_pos": "856", "end_pos": "856" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H1R9-1.856.856", "start_pos": 856, "end_pos": 856, "uniprot_canonical_ac": "G3H1R9-1", "length": 877, "uniprot_id": "G3H1R9_CRIGR", "protein_name": "KAT8 regulatory NSL complex subunit 3", "refseq_ac": "XP_007624010", "refseq_name": "KAT8 regulatory NSL complex subunit 3 isoform X2", "gene_name": "Kansl3", "gene_names_uniprotkb": "Kansl3", "gene_names_refseq": "Kansl3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H1R9", "url": "https://www.uniprot.org/uniprotkb/G3H1R9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LTLRGQPSRITTLSPIGSGA", "down_seq": "PSEEPASQMLPSNSQRLPPA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr856", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "791", "end_pos": "791" }, { "start_pos": "856", "end_pos": "856" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H1S7-1.139.139", "start_pos": 139, "end_pos": 139, "uniprot_canonical_ac": "G3H1S7-1", "length": 221, "uniprot_id": "G3H1S7_CRIGR", "protein_name": "Pleckstrin homology domain-containing family B member 2 isoform X1", "refseq_ac": "XP_003498348", "refseq_name": "pleckstrin homology domain-containing family B member 2 isoform X1", "gene_name": "Plekhb2", "gene_names_uniprotkb": "Plekhb2", "gene_names_refseq": "Plekhb2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H1S7", "url": "https://www.uniprot.org/uniprotkb/G3H1S7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LSEETAVAASPPPYAAYAAP", "down_seq": "PEVYGYGPYSGAYPAGTQVV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr139", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "139", "end_pos": "139" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H1V8-1.248.248", "start_pos": 248, "end_pos": 248, "uniprot_canonical_ac": "G3H1V8-1", "length": 494, "uniprot_id": "G3H1V8_CRIGR", "protein_name": "WAS/WASL-interacting protein family member 1", "refseq_ac": "XP_027267546", "refseq_name": "WAS/WASL-interacting protein family member 1", "gene_name": "Wipf1", "gene_names_uniprotkb": "Wipf1", "gene_names_refseq": "Wipf1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H1V8", "url": "https://www.uniprot.org/uniprotkb/G3H1V8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SVRQNPSSSSSPFSRPPLPP", "down_seq": "PSRALDDKPPPPPPPVGNRP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr248", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "248", "end_pos": "248" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H203-1.346.346", "start_pos": 346, "end_pos": 346, "uniprot_canonical_ac": "G3H203-1", "length": 351, "uniprot_id": "G3H203_CRIGR", "protein_name": "Nuclear inhibitor of protein phosphatase 1", "refseq_ac": "XP_003498435", "refseq_name": "nuclear inhibitor of protein phosphatase 1 isoform X1", "gene_name": "Ppp1r8", "gene_names_uniprotkb": "Ppp1r8", "gene_names_refseq": "Ppp1r8", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H203", "url": "https://www.uniprot.org/uniprotkb/G3H203" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AVNEPKKKKYAKEAWPGKKP", "down_seq": "PSLLI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr346", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "346", "end_pos": "346" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H2G0-1.201.201", "start_pos": 201, "end_pos": 201, "uniprot_canonical_ac": "G3H2G0-1", "length": 299, "uniprot_id": "G3H2G0_CRIGR", "protein_name": "POU domain class 2-associating factor 1", "refseq_ac": "XP_035303588", "refseq_name": "POU domain class 2-associating factor 1", "gene_name": "Pou2af1", "gene_names_uniprotkb": "Pou2af1", "gene_names_refseq": "Pou2af1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H2G0", "url": "https://www.uniprot.org/uniprotkb/G3H2G0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SVLTYASPPLITNVTPRSTA", "down_seq": "PAVGPQLEGPEHQAPLTYFP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr201", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "201", "end_pos": "201" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H2P2-1.220.220", "start_pos": 220, "end_pos": 220, "uniprot_canonical_ac": "G3H2P2-1", "length": 447, "uniprot_id": "G3H2P2_CRIGR", "protein_name": "Transmembrane protein with metallophosphoesterase domain", "refseq_ac": "XP_007628378", "refseq_name": "transmembrane protein with metallophosphoesterase domain", "gene_name": "Tmppe", "gene_names_uniprotkb": "Tmppe", "gene_names_refseq": "Tmppe", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H2P2", "url": "https://www.uniprot.org/uniprotkb/G3H2P2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LPASMNNLRIVLLSDIHLGP", "down_seq": "VGRTKMEMFVRMVNTLEPDI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr220", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "220", "end_pos": "220" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H301-1.192.192", "start_pos": 192, "end_pos": 192, "uniprot_canonical_ac": "G3H301-1", "length": 657, "uniprot_id": "G3H301_CRIGR", "protein_name": "DNA-binding protein RFX5 isoform X1", "refseq_ac": "XP_035304406", "refseq_name": "DNA-binding protein RFX5 isoform X1", "gene_name": "Rfx5", "gene_names_uniprotkb": "Rfx5", "gene_names_refseq": "Rfx5", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H301", "url": "https://www.uniprot.org/uniprotkb/G3H301" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PPLPGLDLKGSESPEMGPEV", "down_seq": "PAPRDELVEAACALTCDWAE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr192", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "192", "end_pos": "192" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H3A4-1.110.110", "start_pos": 110, "end_pos": 110, "uniprot_canonical_ac": "G3H3A4-1", "length": 237, "uniprot_id": "G3H3A4_CRIGR", "protein_name": "Cell division cycle-associated protein 4", "refseq_ac": "XP_003498794", "refseq_name": "cell division cycle-associated protein 4", "gene_name": "Cdca4", "gene_names_uniprotkb": "Cdca4", "gene_names_refseq": "Cdca4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H3A4", "url": "https://www.uniprot.org/uniprotkb/G3H3A4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RLVSTEILCRTARAADEEHP", "down_seq": "PELEDGPLQSSASELPIVSP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr110", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "110", "end_pos": "110" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H4H2-1.547.547", "start_pos": 547, "end_pos": 547, "uniprot_canonical_ac": "G3H4H2-1", "length": 650, "uniprot_id": "G3H4H2_CRIGR", "protein_name": "Uncharacterized protein C19orf44 homolog isoform X1", "refseq_ac": "XP_035307343", "refseq_name": "uncharacterized protein C19orf44 homolog isoform X1", "gene_name": "C1H19orf44", "gene_names_uniprotkb": "C1H19orf44", "gene_names_refseq": "C1H19orf44", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H4H2", "url": "https://www.uniprot.org/uniprotkb/G3H4H2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LDPAFVYQWSKAGGMAAIGP", "down_seq": "LGGAYVDPAPIASHVVSADA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr547", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "547", "end_pos": "547" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H5B1-1.92.92", "start_pos": 92, "end_pos": 92, "uniprot_canonical_ac": "G3H5B1-1", "length": 366, "uniprot_id": "G3H5B1_CRIGR", "protein_name": "Krueppel-like factor 5 isoform X3", "refseq_ac": "XP_027249805", "refseq_name": "Krueppel-like factor 5 isoform X3", "gene_name": "Klf5", "gene_names_uniprotkb": "Klf5", "gene_names_refseq": "Klf5", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H5B1", "url": "https://www.uniprot.org/uniprotkb/G3H5B1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TEPVAIFSHQSETTAPPPAP", "down_seq": "QALPEFNSIFSSHQNTAPEV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr92", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "92", "end_pos": "92" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H5N1-1.496.496", "start_pos": 496, "end_pos": 496, "uniprot_canonical_ac": "G3H5N1-1", "length": 1224, "uniprot_id": "G3H5N1_CRIGR", "protein_name": "Zinc finger protein 423", "refseq_ac": "XP_027290429", "refseq_name": "zinc finger protein 423 isoform X1", "gene_name": "Znf423", "gene_names_uniprotkb": "Znf423", "gene_names_refseq": "Znf423", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H5N1", "url": "https://www.uniprot.org/uniprotkb/G3H5N1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "IQQAHCSVGSTKLESPVVQP", "down_seq": "QSFMEVYSCPYCTNSPIFGS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr496", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "496", "end_pos": "496" }, { "start_pos": "788", "end_pos": "788" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H5N1-1.788.788", "start_pos": 788, "end_pos": 788, "uniprot_canonical_ac": "G3H5N1-1", "length": 1224, "uniprot_id": "G3H5N1_CRIGR", "protein_name": "Zinc finger protein 423", "refseq_ac": "XP_027290429", "refseq_name": "zinc finger protein 423 isoform X1", "gene_name": "Znf423", "gene_names_uniprotkb": "Znf423", "gene_names_refseq": "Znf423", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H5N1", "url": "https://www.uniprot.org/uniprotkb/G3H5N1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EKHCVFDAAAENGTTNGVPP", "down_seq": "STKKAEPADLQGMLLKNPEA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr788", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "496", "end_pos": "496" }, { "start_pos": "788", "end_pos": "788" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H651-1.214.214", "start_pos": 214, "end_pos": 214, "uniprot_canonical_ac": "G3H651-1", "length": 398, "uniprot_id": "G3H651_CRIGR", "protein_name": "CLOCK-interacting pacemaker", "refseq_ac": "XP_003499715", "refseq_name": "CLOCK-interacting pacemaker", "gene_name": "Cipc", "gene_names_uniprotkb": "Cipc", "gene_names_refseq": "Cipc", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H651", "url": "https://www.uniprot.org/uniprotkb/G3H651" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GPVLSSSEPAKTGPVLSSPS", "down_seq": "PAPPSSKLTEDSALQGVPSL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr214", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "214", "end_pos": "214" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H6F3-1.270.270", "start_pos": 270, "end_pos": 270, "uniprot_canonical_ac": "G3H6F3-1", "length": 326, "uniprot_id": "G3H6F3_CRIGR", "protein_name": "F-box/LRR-repeat protein 12", "refseq_ac": "XP_035309966", "refseq_name": "F-box/LRR-repeat protein 12 isoform X1", "gene_name": "Fbxl12", "gene_names_uniprotkb": "Fbxl12", "gene_names_refseq": "Fbxl12", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H6F3", "url": "https://www.uniprot.org/uniprotkb/G3H6F3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GMPALESLCLQGPLITPEMP", "down_seq": "PAQIVTSCLTMPKLRVLEVQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr270", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "270", "end_pos": "270" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H6G6-1.135.135", "start_pos": 135, "end_pos": 135, "uniprot_canonical_ac": "G3H6G6-1", "length": 598, "uniprot_id": "G3H6G6_CRIGR", "protein_name": "Zinc finger protein 317 isoform X1", "refseq_ac": "XP_027290606", "refseq_name": "zinc finger protein 317 isoform X1", "gene_name": "Znf317", "gene_names_uniprotkb": "Znf317", "gene_names_refseq": "Znf317", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H6G6", "url": "https://www.uniprot.org/uniprotkb/G3H6G6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EEELRMEERGMQLGASPDWG", "down_seq": "PSKAKWSIVMDDILGEEASN", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr135", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "135", "end_pos": "135" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H6W6-1.2196.2196", "start_pos": 2196, "end_pos": 2196, "uniprot_canonical_ac": "G3H6W6-1", "length": 2435, "uniprot_id": "G3H6W6_CRIGR", "protein_name": "Transcription factor HIVEP2", "refseq_ac": "XP_035310092", "refseq_name": "transcription factor HIVEP2", "gene_name": "Hivep2", "gene_names_uniprotkb": "Hivep2", "gene_names_refseq": "Hivep2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H6W6", "url": "https://www.uniprot.org/uniprotkb/G3H6W6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "YGDQEGAYEHHGSSLFPEGP", "down_seq": "DYVFSHLPLHSQQQVRAPIP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2196", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "2196", "end_pos": "2196" }, { "start_pos": "861", "end_pos": "861" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H6W6-1.861.861", "start_pos": 861, "end_pos": 861, "uniprot_canonical_ac": "G3H6W6-1", "length": 2435, "uniprot_id": "G3H6W6_CRIGR", "protein_name": "Transcription factor HIVEP2", "refseq_ac": "XP_035310092", "refseq_name": "transcription factor HIVEP2", "gene_name": "Hivep2", "gene_names_uniprotkb": "Hivep2", "gene_names_refseq": "Hivep2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H6W6", "url": "https://www.uniprot.org/uniprotkb/G3H6W6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "APISPEWAPPGDGAESGSKP", "down_seq": "PSQQVPQPSYHAQPRLVRQH", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr861", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "2196", "end_pos": "2196" }, { "start_pos": "861", "end_pos": "861" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H761-1.235.235", "start_pos": 235, "end_pos": 235, "uniprot_canonical_ac": "G3H761-1", "length": 1563, "uniprot_id": "G3H761_CRIGR", "protein_name": "Superkiller complex protein 3", "refseq_ac": "XP_007638936", "refseq_name": "tetratricopeptide repeat protein 37", "gene_name": "Ttc37", "gene_names_uniprotkb": "Ttc37", "gene_names_refseq": "Ttc37", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H761", "url": "https://www.uniprot.org/uniprotkb/G3H761" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LPHETSRLKNACEGMINIYP", "down_seq": "VQYPLEVISLHLIESGSLTD", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr235", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "235", "end_pos": "235" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H893-1.168.168", "start_pos": 168, "end_pos": 168, "uniprot_canonical_ac": "G3H893-1", "length": 242, "uniprot_id": "G3H893_CRIGR", "protein_name": "Protein ABHD14A", "refseq_ac": "XP_007639265", "refseq_name": "protein ABHD14A", "gene_name": "Abhd14a", "gene_names_uniprotkb": "Abhd14a", "gene_names_refseq": "Abhd14a", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H893", "url": "https://www.uniprot.org/uniprotkb/G3H893" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ALPFLMRSHHQLRGFVPIAP", "down_seq": "STRNYTKEQFWAVKTPTLIM", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr168", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "168", "end_pos": "168" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "G3H895-1.319.319", "start_pos": 319, "end_pos": 319, "uniprot_canonical_ac": "G3H895-1", "length": 403, "uniprot_id": "G3H895_CRIGR", "protein_name": "Poly(rC)-binding protein 4", "refseq_ac": "XP_003500399", "refseq_name": "poly(rC)-binding protein 4 isoform X1", "gene_name": "Pcbp4", "gene_names_uniprotkb": "Pcbp4", "gene_names_refseq": "Pcbp4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "G3H895", "url": "https://www.uniprot.org/uniprotkb/G3H895" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ALAQYLITACLETAKSTSGG", "down_seq": "PGSAPADLPTPFSPPLTALP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr319", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "319", "end_pos": "319" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A061HZ27-1.182.182", "start_pos": 182, "end_pos": 182, "uniprot_canonical_ac": "A0A061HZ27-1", "length": 1102, "uniprot_id": "A0A061HZ27_CRIGR", "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform", "refseq_ac": "XP_027239786", "refseq_name": "phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform", "gene_name": "Pik3cg", "gene_names_uniprotkb": "Pik3cg", "gene_names_refseq": "Pik3cg", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A061HZ27", "url": "https://www.uniprot.org/uniprotkb/A0A061HZ27" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VTDISNVHDDELEFTRRRLV", "down_seq": "PRMAEVAGRDAKLYAMHPWV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr182", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "182", "end_pos": "182" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A061HZ66-1.53.53", "start_pos": 53, "end_pos": 53, "uniprot_canonical_ac": "A0A061HZ66-1", "length": 805, "uniprot_id": "A0A061HZ66_CRIGR", "protein_name": "Angiotensin-converting enzyme", "refseq_ac": "XP_027288607", "refseq_name": "angiotensin-converting enzyme 2", "gene_name": "Ace2", "gene_names_uniprotkb": "Ace2", "gene_names_refseq": "Ace2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A061HZ66", "url": "https://www.uniprot.org/uniprotkb/A0A061HZ66" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A061HZ66", "url": "https://www.uniprot.org/uniprotkb/A0A061HZ66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR601548-10", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR601548-10", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "NQEAEDLSYQSALASWNYNT", "down_seq": "ITEENAQKMNEAAAKWSAFY", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn53", "evidence": [ { "id": "A0A061HZ66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A061HZ66#ptm_processing" }, { "id": "PIRSR601548-10", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR601548-10" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "53", "end_pos": "53" }, { "start_pos": "578", "end_pos": "578" }, { "start_pos": "90", "end_pos": "90" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A061HZ66-1.578.578", "start_pos": 578, "end_pos": 578, "uniprot_canonical_ac": "A0A061HZ66-1", "length": 805, "uniprot_id": "A0A061HZ66_CRIGR", "protein_name": "Angiotensin-converting enzyme", "refseq_ac": "XP_027288607", "refseq_name": "angiotensin-converting enzyme 2", "gene_name": "Ace2", "gene_names_uniprotkb": "Ace2", "gene_names_refseq": "Ace2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A061HZ66", "url": "https://www.uniprot.org/uniprotkb/A0A061HZ66" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A061HZ66", "url": "https://www.uniprot.org/uniprotkb/A0A061HZ66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR601548-10", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR601548-10", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "LRLGKSEPWTLALENVVGAR", "down_seq": "MDVRPLLNYFEPLSVWLKEQ", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn578", "evidence": [ { "id": "A0A061HZ66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A061HZ66#ptm_processing" }, { "id": "PIRSR601548-10", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR601548-10" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "53", "end_pos": "53" }, { "start_pos": "578", "end_pos": "578" }, { "start_pos": "90", "end_pos": "90" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A061HZ66-1.90.90", "start_pos": 90, "end_pos": 90, "uniprot_canonical_ac": "A0A061HZ66-1", "length": 805, "uniprot_id": "A0A061HZ66_CRIGR", "protein_name": "Angiotensin-converting enzyme", "refseq_ac": "XP_027288607", "refseq_name": "angiotensin-converting enzyme 2", "gene_name": "Ace2", "gene_names_uniprotkb": "Ace2", "gene_names_refseq": "Ace2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A061HZ66", "url": "https://www.uniprot.org/uniprotkb/A0A061HZ66" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A061HZ66", "url": "https://www.uniprot.org/uniprotkb/A0A061HZ66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR601548-10", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR601548-10", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "SAFYEEQSKLAKNYSLQEVQ", "down_seq": "LIIKRQLQALQQSGSSALSA", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "Complex", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) (complex) asparagine;Complex", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn90", "evidence": [ { "id": "A0A061HZ66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A061HZ66#ptm_processing" }, { "id": "PIRSR601548-10", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR601548-10" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "53", "end_pos": "53" }, { "start_pos": "578", "end_pos": "578" }, { "start_pos": "90", "end_pos": "90" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A061I498-1.176.176", "start_pos": 176, "end_pos": 176, "uniprot_canonical_ac": "A0A061I498-1", "length": 926, "uniprot_id": "A0A061I498_CRIGR", "protein_name": "Disks large homolog 1", "refseq_ac": "XP_007638704", "refseq_name": "disks large homolog 1 isoform X1", "gene_name": "Dlg1", "gene_names_uniprotkb": "Dlg1", "gene_names_refseq": "Dlg1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A061I498", "url": "https://www.uniprot.org/uniprotkb/A0A061I498" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "HISPVKPTEAVPPSSPTVPV", "down_seq": "PALPVPAESTVVLSTAPQAN", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr176", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "176", "end_pos": "176" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A061I4L0-1.287.287", "start_pos": 287, "end_pos": 287, "uniprot_canonical_ac": "A0A061I4L0-1", "length": 311, "uniprot_id": "A0A061I4L0_CRIGR", "protein_name": "NAD-dependent protein lipoamidase sirtuin-4, mitochondrial", "refseq_ac": "XP_003495965", "refseq_name": "NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1", "gene_name": "Sirt4", "gene_names_uniprotkb": "Sirt4; SIRT4", "gene_names_refseq": "Sirt4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A061I4L0", "url": "https://www.uniprot.org/uniprotkb/A0A061I4L0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RFILTAREKKLPIAILNIGP", "down_seq": "RSDDLACLKLDSRCGELLPL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr287", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "287", "end_pos": "287" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A061IBP3-1.81.81", "start_pos": 81, "end_pos": 81, "uniprot_canonical_ac": "A0A061IBP3-1", "length": 439, "uniprot_id": "A0A061IBP3_CRIGR", "protein_name": "Battenin", "refseq_ac": "XP_027260461", "refseq_name": "battenin isoform X4", "gene_name": "Cln3", "gene_names_uniprotkb": "Cln3", "gene_names_refseq": "Cln3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A061IBP3", "url": "https://www.uniprot.org/uniprotkb/A0A061IBP3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "HDILKYKQASGNQSHVEPSP", "down_seq": "PMTHNSSSRFDCNSISTAAV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr81", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "81", "end_pos": "81" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A061ICE1-1.45.45", "start_pos": 45, "end_pos": 45, "uniprot_canonical_ac": "A0A061ICE1-1", "length": 458, "uniprot_id": "A0A061ICE1_CRIGR", "protein_name": "Histone acetyltransferase", "refseq_ac": "XP_027260323", "refseq_name": "histone acetyltransferase KAT8 isoform X1", "gene_name": "Kat8", "gene_names_uniprotkb": "Kat8", "gene_names_refseq": "Kat8", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A061ICE1", "url": "https://www.uniprot.org/uniprotkb/A0A061ICE1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PGENAAVEGPAGSPGRVSPP", "down_seq": "PARGEPEVTVEIGETYLCRR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr45", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "45", "end_pos": "45" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A061ICU9-1.511.511", "start_pos": 511, "end_pos": 511, "uniprot_canonical_ac": "A0A061ICU9-1", "length": 574, "uniprot_id": "A0A061ICU9_CRIGR", "protein_name": "E3 ubiquitin-protein ligase NEURL1", "refseq_ac": "XP_027262882", "refseq_name": "E3 ubiquitin-protein ligase NEURL1 isoform X2", "gene_name": "Neurl1", "gene_names_uniprotkb": "Neurl1", "gene_names_refseq": "Neurl1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A061ICU9", "url": "https://www.uniprot.org/uniprotkb/A0A061ICU9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GGSTGGTAPNSPVSLPESPV", "down_seq": "PGMGQWGDECTICYEHAVDT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr511", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "511", "end_pos": "511" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7GL96-1.62.62", "start_pos": 62, "end_pos": 62, "uniprot_canonical_ac": "A0A3L7GL96-1", "length": 232, "uniprot_id": "A0A3L7GL96_CRIGR", "protein_name": "Noggin", "refseq_ac": "XP_027281916", "refseq_name": "noggin isoform X2", "gene_name": "Nog", "gene_names_uniprotkb": "Nog", "gene_names_refseq": "Nog", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7GL96", "url": "https://www.uniprot.org/uniprotkb/A0A3L7GL96" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A3L7GL96", "url": "https://www.uniprot.org/uniprotkb/A0A3L7GL96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR008129-2", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR008129-2", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "PLVDLIEHPDPIFDPKEKDL", "down_seq": "ETLLRSLLGGHYDPGFMATS", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn62", "evidence": [ { "id": "A0A3L7GL96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3L7GL96#ptm_processing" }, { "id": "PIRSR008129-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR008129-2" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "62", "end_pos": "62" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7GMP6-1.582.582", "start_pos": 582, "end_pos": 582, "uniprot_canonical_ac": "A0A3L7GMP6-1", "length": 806, "uniprot_id": "A0A3L7GMP6_CRIGR", "protein_name": "Mitogen-activated protein kinase", "refseq_ac": "XP_027283045", "refseq_name": "mitogen-activated protein kinase 7 isoform X2", "gene_name": "Mapk7", "gene_names_uniprotkb": "Mapk7", "gene_names_refseq": "Mapk7", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7GMP6", "url": "https://www.uniprot.org/uniprotkb/A0A3L7GMP6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SDNDRSLLERWTRMARPPAP", "down_seq": "PAPAPAPSPAQPASPPTGPV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr582", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "582", "end_pos": "582" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LVE3-1.108.108", "start_pos": 108, "end_pos": 108, "uniprot_canonical_ac": "A0A8C2LVE3-1", "length": 356, "uniprot_id": "HS2ST_CRIGR", "protein_name": "Heparan sulfate 2-O-sulfotransferase 1", "refseq_ac": "", "refseq_name": "", "gene_name": "HS2ST1", "gene_names_uniprotkb": "HS2ST1; LOC100760748", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PRU00498", "url": "https://prosite.expasy.org/rule/PRU00498", "database": "PROSITE-ProRule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "SFTNIAYDLCAKNRYHVLHI", "down_seq": "TTKNNPVMSLQDQVRFVKNI", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn108", "evidence": [ { "id": "A0A8C2LVE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "108", "end_pos": "108" }, { "start_pos": "127", "end_pos": "127" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "164", "end_pos": "164" }, { "start_pos": "172", "end_pos": "172" }, { "start_pos": "178", "end_pos": "178" }, { "start_pos": "181", "end_pos": "181" }, { "start_pos": "188", "end_pos": "188" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "288", "end_pos": "288" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "83", "end_pos": "83" }, { "start_pos": "84", "end_pos": "84" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "87", "end_pos": "87" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "upstream", "id": "A0A8C2LVE3-1.127.127", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LVE3-1.127.127", "start_pos": 127, "end_pos": 127, "uniprot_canonical_ac": "A0A8C2LVE3-1", "length": 356, "uniprot_id": "HS2ST_CRIGR", "protein_name": "Heparan sulfate 2-O-sulfotransferase 1", "refseq_ac": "", "refseq_name": "", "gene_name": "HS2ST1", "gene_names_uniprotkb": "HS2ST1; LOC100760748", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PRU00498", "url": "https://prosite.expasy.org/rule/PRU00498", "database": "PROSITE-ProRule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "INTTKNNPVMSLQDQVRFVK", "down_seq": "ITTWNEMKPGFYHGHISYLD", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn127", "evidence": [ { "id": "A0A8C2LVE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "108", "end_pos": "108" }, { "start_pos": "127", "end_pos": "127" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "164", "end_pos": "164" }, { "start_pos": "172", "end_pos": "172" }, { "start_pos": "178", "end_pos": "178" }, { "start_pos": "181", "end_pos": "181" }, { "start_pos": "188", "end_pos": "188" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "288", "end_pos": "288" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "83", "end_pos": "83" }, { "start_pos": "84", "end_pos": "84" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "87", "end_pos": "87" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "A0A8C2LVE3-1.108.108", "categories": [ "glycosylation_flag" ] }, { "distance": 13, "direction": "upstream", "id": "A0A8C2LVE3-1.140.140", "categories": [ "mutagenesis_flag" ] }, { "distance": 15, "direction": "upstream", "id": "A0A8C2LVE3-1.142.142", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LVE3-1.140.140", "start_pos": 140, "end_pos": 140, "uniprot_canonical_ac": "A0A8C2LVE3-1", "length": 356, "uniprot_id": "HS2ST_CRIGR", "protein_name": "Heparan sulfate 2-O-sulfotransferase 1", "refseq_ac": "", "refseq_name": "", "gene_name": "HS2ST1", "gene_names_uniprotkb": "HS2ST1; LOC100760748", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [ { "title": "Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Xu D, Song D, Pedersen LC, Liu J", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "reference": [ { "type": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "crossref": [ { "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "H", "start_aa": "H", "up_seq": "DQVRFVKNITTWNEMKPGFY", "down_seq": "GHISYLDFAKFGVKKKPIYI", "mutagenesis": [ { "sequence_org": "H", "sequence_mut": "A", "comment": "Severely abrogates catalytic activity but does not affect 3'-phosphoadenylyl sulfate substrate binding. Completely abolishes catalytic activity; when associated with A-142.", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" }, { "database": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "108", "end_pos": "108" }, { "start_pos": "127", "end_pos": "127" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "164", "end_pos": "164" }, { "start_pos": "172", "end_pos": "172" }, { "start_pos": "178", "end_pos": "178" }, { "start_pos": "181", "end_pos": "181" }, { "start_pos": "188", "end_pos": "188" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "288", "end_pos": "288" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "83", "end_pos": "83" }, { "start_pos": "84", "end_pos": "84" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "87", "end_pos": "87" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 13, "direction": "downstream", "id": "A0A8C2LVE3-1.127.127", "categories": [ "glycosylation_flag" ] }, { "distance": 2, "direction": "upstream", "id": "A0A8C2LVE3-1.142.142", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "A0A8C2LVE3-1.142.142", "start_pos": 142, "end_pos": 142, "uniprot_canonical_ac": "A0A8C2LVE3-1", "length": 356, "uniprot_id": "HS2ST_CRIGR", "protein_name": "Heparan sulfate 2-O-sulfotransferase 1", "refseq_ac": "", "refseq_name": "", "gene_name": "HS2ST1", "gene_names_uniprotkb": "HS2ST1; LOC100760748", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [ { "title": "Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Xu D, Song D, Pedersen LC, Liu J", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "reference": [ { "type": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "crossref": [ { "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "H", "start_aa": "H", "up_seq": "VRFVKNITTWNEMKPGFYHG", "down_seq": "ISYLDFAKFGVKKKPIYINV", "mutagenesis": [ { "sequence_org": "H", "sequence_mut": "A", "comment": "Severely abrogates catalytic activity but does not affect 3'-phosphoadenylyl sulfate substrate binding. Completely abolishes catalytic activity; when associated with A-140.", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" }, { "database": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "108", "end_pos": "108" }, { "start_pos": "127", "end_pos": "127" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "164", "end_pos": "164" }, { "start_pos": "172", "end_pos": "172" }, { "start_pos": "178", "end_pos": "178" }, { "start_pos": "181", "end_pos": "181" }, { "start_pos": "188", "end_pos": "188" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "288", "end_pos": "288" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "83", "end_pos": "83" }, { "start_pos": "84", "end_pos": "84" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "87", "end_pos": "87" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 15, "direction": "downstream", "id": "A0A8C2LVE3-1.127.127", "categories": [ "glycosylation_flag" ] }, { "distance": 2, "direction": "downstream", "id": "A0A8C2LVE3-1.140.140", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "A0A8C2LVE3-1.164.164", "start_pos": 164, "end_pos": 164, "uniprot_canonical_ac": "A0A8C2LVE3-1", "length": 356, "uniprot_id": "HS2ST_CRIGR", "protein_name": "Heparan sulfate 2-O-sulfotransferase 1", "refseq_ac": "", "refseq_name": "", "gene_name": "HS2ST1", "gene_names_uniprotkb": "HS2ST1; LOC100760748", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [ { "title": "Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Xu D, Song D, Pedersen LC, Liu J", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "reference": [ { "type": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "crossref": [ { "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "SYLDFAKFGVKKKPIYINVI", "down_seq": "DPIERLVSYYYFLRFGDDYR", "mutagenesis": [ { "sequence_org": "R", "sequence_mut": "A", "comment": "Severe reduction of catalytic activity due to disruption of binding to the substrate 3'-phosphoadenylyl sulfate.", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" }, { "database": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "108", "end_pos": "108" }, { "start_pos": "127", "end_pos": "127" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "164", "end_pos": "164" }, { "start_pos": "172", "end_pos": "172" }, { "start_pos": "178", "end_pos": "178" }, { "start_pos": "181", "end_pos": "181" }, { "start_pos": "188", "end_pos": "188" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "288", "end_pos": "288" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "83", "end_pos": "83" }, { "start_pos": "84", "end_pos": "84" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "87", "end_pos": "87" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 8, "direction": "upstream", "id": "A0A8C2LVE3-1.172.172", "categories": [ "mutagenesis_flag" ] }, { "distance": 14, "direction": "upstream", "id": "A0A8C2LVE3-1.178.178", "categories": [ "mutagenesis_flag" ] }, { "distance": 17, "direction": "upstream", "id": "A0A8C2LVE3-1.181.181", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "A0A8C2LVE3-1.172.172", "start_pos": 172, "end_pos": 172, "uniprot_canonical_ac": "A0A8C2LVE3-1", "length": 356, "uniprot_id": "HS2ST_CRIGR", "protein_name": "Heparan sulfate 2-O-sulfotransferase 1", "refseq_ac": "", "refseq_name": "", "gene_name": "HS2ST1", "gene_names_uniprotkb": "HS2ST1; LOC100760748", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [ { "title": "Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Xu D, Song D, Pedersen LC, Liu J", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "reference": [ { "type": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "crossref": [ { "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "GVKKKPIYINVIRDPIERLV", "down_seq": "YYYFLRFGDDYRPGLRRRKQ", "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "Severe reduction of catalytic activity due to disruption of binding to the substrate 3'-phosphoadenylyl sulfate.", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" }, { "database": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "108", "end_pos": "108" }, { "start_pos": "127", "end_pos": "127" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "164", "end_pos": "164" }, { "start_pos": "172", "end_pos": "172" }, { "start_pos": "178", "end_pos": "178" }, { "start_pos": "181", "end_pos": "181" }, { "start_pos": "188", "end_pos": "188" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "288", "end_pos": "288" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "83", "end_pos": "83" }, { "start_pos": "84", "end_pos": "84" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "87", "end_pos": "87" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 8, "direction": "downstream", "id": "A0A8C2LVE3-1.164.164", "categories": [ "mutagenesis_flag" ] }, { "distance": 6, "direction": "upstream", "id": "A0A8C2LVE3-1.178.178", "categories": [ "mutagenesis_flag" ] }, { "distance": 9, "direction": "upstream", "id": "A0A8C2LVE3-1.181.181", "categories": [ "mutagenesis_flag" ] }, { "distance": 16, "direction": "upstream", "id": "A0A8C2LVE3-1.188.188", "categories": [ "mutagenesis_flag" ] }, { "distance": 17, "direction": "upstream", "id": "A0A8C2LVE3-1.189.189", "categories": [ "mutagenesis_flag" ] }, { "distance": 18, "direction": "upstream", "id": "A0A8C2LVE3-1.190.190", "categories": [ "mutagenesis_flag" ] }, { "distance": 19, "direction": "upstream", "id": "A0A8C2LVE3-1.191.191", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "A0A8C2LVE3-1.178.178", "start_pos": 178, "end_pos": 178, "uniprot_canonical_ac": "A0A8C2LVE3-1", "length": 356, "uniprot_id": "HS2ST_CRIGR", "protein_name": "Heparan sulfate 2-O-sulfotransferase 1", "refseq_ac": "", "refseq_name": "", "gene_name": "HS2ST1", "gene_names_uniprotkb": "HS2ST1; LOC100760748", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [ { "title": "Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Xu D, Song D, Pedersen LC, Liu J", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "reference": [ { "type": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "crossref": [ { "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "IYINVIRDPIERLVSYYYFL", "down_seq": "FGDDYRPGLRRRKQGDKKTF", "mutagenesis": [ { "sequence_org": "R", "sequence_mut": "A", "comment": "Severe reduction of catalytic activity but no effect on 3'-phosphoadenylyl sulfate substrate binding; probably disrupts binding to the polysaccharide substrate.", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" }, { "database": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "108", "end_pos": "108" }, { "start_pos": "127", "end_pos": "127" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "164", "end_pos": "164" }, { "start_pos": "172", "end_pos": "172" }, { "start_pos": "178", "end_pos": "178" }, { "start_pos": "181", "end_pos": "181" }, { "start_pos": "188", "end_pos": "188" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "288", "end_pos": "288" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "83", "end_pos": "83" }, { "start_pos": "84", "end_pos": "84" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "87", "end_pos": "87" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 14, "direction": "downstream", "id": "A0A8C2LVE3-1.164.164", "categories": [ "mutagenesis_flag" ] }, { "distance": 6, "direction": "downstream", "id": "A0A8C2LVE3-1.172.172", "categories": [ "mutagenesis_flag" ] }, { "distance": 3, "direction": "upstream", "id": "A0A8C2LVE3-1.181.181", "categories": [ "mutagenesis_flag" ] }, { "distance": 10, "direction": "upstream", "id": "A0A8C2LVE3-1.188.188", "categories": [ "mutagenesis_flag" ] }, { "distance": 11, "direction": "upstream", "id": "A0A8C2LVE3-1.189.189", "categories": [ "mutagenesis_flag" ] }, { "distance": 12, "direction": "upstream", "id": "A0A8C2LVE3-1.190.190", "categories": [ "mutagenesis_flag" ] }, { "distance": 13, "direction": "upstream", "id": "A0A8C2LVE3-1.191.191", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "A0A8C2LVE3-1.181.181", "start_pos": 181, "end_pos": 181, "uniprot_canonical_ac": "A0A8C2LVE3-1", "length": 356, "uniprot_id": "HS2ST_CRIGR", "protein_name": "Heparan sulfate 2-O-sulfotransferase 1", "refseq_ac": "", "refseq_name": "", "gene_name": "HS2ST1", "gene_names_uniprotkb": "HS2ST1; LOC100760748", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [ { "title": "Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Xu D, Song D, Pedersen LC, Liu J", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "reference": [ { "type": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "crossref": [ { "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "NVIRDPIERLVSYYYFLRFG", "down_seq": "DYRPGLRRRKQGDKKTFDEC", "mutagenesis": [ { "sequence_org": "D", "sequence_mut": "A", "comment": "Severe reduction of catalytic activity but no effect on 3'-phosphoadenylyl sulfate substrate binding; probably disrupts binding to the polysaccharide substrate.", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" }, { "database": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "108", "end_pos": "108" }, { "start_pos": "127", "end_pos": "127" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "164", "end_pos": "164" }, { "start_pos": "172", "end_pos": "172" }, { "start_pos": "178", "end_pos": "178" }, { "start_pos": "181", "end_pos": "181" }, { "start_pos": "188", "end_pos": "188" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "288", "end_pos": "288" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "83", "end_pos": "83" }, { "start_pos": "84", "end_pos": "84" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "87", "end_pos": "87" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 17, "direction": "downstream", "id": "A0A8C2LVE3-1.164.164", "categories": [ "mutagenesis_flag" ] }, { "distance": 9, "direction": "downstream", "id": "A0A8C2LVE3-1.172.172", "categories": [ "mutagenesis_flag" ] }, { "distance": 3, "direction": "downstream", "id": "A0A8C2LVE3-1.178.178", "categories": [ "mutagenesis_flag" ] }, { "distance": 7, "direction": "upstream", "id": "A0A8C2LVE3-1.188.188", "categories": [ "mutagenesis_flag" ] }, { "distance": 8, "direction": "upstream", "id": "A0A8C2LVE3-1.189.189", "categories": [ "mutagenesis_flag" ] }, { "distance": 9, "direction": "upstream", "id": "A0A8C2LVE3-1.190.190", "categories": [ "mutagenesis_flag" ] }, { "distance": 10, "direction": "upstream", "id": "A0A8C2LVE3-1.191.191", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "A0A8C2LVE3-1.188.188", "start_pos": 188, "end_pos": 188, "uniprot_canonical_ac": "A0A8C2LVE3-1", "length": 356, "uniprot_id": "HS2ST_CRIGR", "protein_name": "Heparan sulfate 2-O-sulfotransferase 1", "refseq_ac": "", "refseq_name": "", "gene_name": "HS2ST1", "gene_names_uniprotkb": "HS2ST1; LOC100760748", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [ { "title": "Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Xu D, Song D, Pedersen LC, Liu J", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "reference": [ { "type": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "crossref": [ { "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "ERLVSYYYFLRFGDDYRPGL", "down_seq": "RRKQGDKKTFDECVAEGGSD", "mutagenesis": [ { "sequence_org": "R", "sequence_mut": "A", "comment": "No effect on catalytic activity.", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" }, { "database": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "108", "end_pos": "108" }, { "start_pos": "127", "end_pos": "127" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "164", "end_pos": "164" }, { "start_pos": "172", "end_pos": "172" }, { "start_pos": "178", "end_pos": "178" }, { "start_pos": "181", "end_pos": "181" }, { "start_pos": "188", "end_pos": "188" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "288", "end_pos": "288" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "83", "end_pos": "83" }, { "start_pos": "84", "end_pos": "84" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "87", "end_pos": "87" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 16, "direction": "downstream", "id": "A0A8C2LVE3-1.172.172", "categories": [ "mutagenesis_flag" ] }, { "distance": 10, "direction": "downstream", "id": "A0A8C2LVE3-1.178.178", "categories": [ "mutagenesis_flag" ] }, { "distance": 7, "direction": "downstream", "id": "A0A8C2LVE3-1.181.181", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "upstream", "id": "A0A8C2LVE3-1.189.189", "categories": [ "mutagenesis_flag" ] }, { "distance": 2, "direction": "upstream", "id": "A0A8C2LVE3-1.190.190", "categories": [ "mutagenesis_flag" ] }, { "distance": 3, "direction": "upstream", "id": "A0A8C2LVE3-1.191.191", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "A0A8C2LVE3-1.189.189", "start_pos": 189, "end_pos": 189, "uniprot_canonical_ac": "A0A8C2LVE3-1", "length": 356, "uniprot_id": "HS2ST_CRIGR", "protein_name": "Heparan sulfate 2-O-sulfotransferase 1", "refseq_ac": "", "refseq_name": "", "gene_name": "HS2ST1", "gene_names_uniprotkb": "HS2ST1; LOC100760748", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [ { "title": "Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Xu D, Song D, Pedersen LC, Liu J", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "reference": [ { "type": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "crossref": [ { "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "RLVSYYYFLRFGDDYRPGLR", "down_seq": "RKQGDKKTFDECVAEGGSDC", "mutagenesis": [ { "sequence_org": "R", "sequence_mut": "A", "comment": "Severe reduction of catalytic activity but no effect on 3'-phosphoadenylyl sulfate substrate binding.", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" }, { "database": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "108", "end_pos": "108" }, { "start_pos": "127", "end_pos": "127" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "164", "end_pos": "164" }, { "start_pos": "172", "end_pos": "172" }, { "start_pos": "178", "end_pos": "178" }, { "start_pos": "181", "end_pos": "181" }, { "start_pos": "188", "end_pos": "188" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "288", "end_pos": "288" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "83", "end_pos": "83" }, { "start_pos": "84", "end_pos": "84" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "87", "end_pos": "87" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 17, "direction": "downstream", "id": "A0A8C2LVE3-1.172.172", "categories": [ "mutagenesis_flag" ] }, { "distance": 11, "direction": "downstream", "id": "A0A8C2LVE3-1.178.178", "categories": [ "mutagenesis_flag" ] }, { "distance": 8, "direction": "downstream", "id": "A0A8C2LVE3-1.181.181", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "downstream", "id": "A0A8C2LVE3-1.188.188", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "upstream", "id": "A0A8C2LVE3-1.190.190", "categories": [ "mutagenesis_flag" ] }, { "distance": 2, "direction": "upstream", "id": "A0A8C2LVE3-1.191.191", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "A0A8C2LVE3-1.190.190", "start_pos": 190, "end_pos": 190, "uniprot_canonical_ac": "A0A8C2LVE3-1", "length": 356, "uniprot_id": "HS2ST_CRIGR", "protein_name": "Heparan sulfate 2-O-sulfotransferase 1", "refseq_ac": "", "refseq_name": "", "gene_name": "HS2ST1", "gene_names_uniprotkb": "HS2ST1; LOC100760748", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [ { "title": "Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Xu D, Song D, Pedersen LC, Liu J", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "reference": [ { "type": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "crossref": [ { "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "LVSYYYFLRFGDDYRPGLRR", "down_seq": "KQGDKKTFDECVAEGGSDCA", "mutagenesis": [ { "sequence_org": "R", "sequence_mut": "A", "comment": "No effect on catalytic activity.", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" }, { "database": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "108", "end_pos": "108" }, { "start_pos": "127", "end_pos": "127" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "164", "end_pos": "164" }, { "start_pos": "172", "end_pos": "172" }, { "start_pos": "178", "end_pos": "178" }, { "start_pos": "181", "end_pos": "181" }, { "start_pos": "188", "end_pos": "188" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "288", "end_pos": "288" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "83", "end_pos": "83" }, { "start_pos": "84", "end_pos": "84" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "87", "end_pos": "87" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 18, "direction": "downstream", "id": "A0A8C2LVE3-1.172.172", "categories": [ "mutagenesis_flag" ] }, { "distance": 12, "direction": "downstream", "id": "A0A8C2LVE3-1.178.178", "categories": [ "mutagenesis_flag" ] }, { "distance": 9, "direction": "downstream", "id": "A0A8C2LVE3-1.181.181", "categories": [ "mutagenesis_flag" ] }, { "distance": 2, "direction": "downstream", "id": "A0A8C2LVE3-1.188.188", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "downstream", "id": "A0A8C2LVE3-1.189.189", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "upstream", "id": "A0A8C2LVE3-1.191.191", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "A0A8C2LVE3-1.191.191", "start_pos": 191, "end_pos": 191, "uniprot_canonical_ac": "A0A8C2LVE3-1", "length": 356, "uniprot_id": "HS2ST_CRIGR", "protein_name": "Heparan sulfate 2-O-sulfotransferase 1", "refseq_ac": "", "refseq_name": "", "gene_name": "HS2ST1", "gene_names_uniprotkb": "HS2ST1; LOC100760748", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [ { "title": "Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Xu D, Song D, Pedersen LC, Liu J", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "reference": [ { "type": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "crossref": [ { "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "VSYYYFLRFGDDYRPGLRRR", "down_seq": "QGDKKTFDECVAEGGSDCAP", "mutagenesis": [ { "sequence_org": "K", "sequence_mut": "A", "comment": "No effect on catalytic activity.", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" }, { "database": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "108", "end_pos": "108" }, { "start_pos": "127", "end_pos": "127" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "164", "end_pos": "164" }, { "start_pos": "172", "end_pos": "172" }, { "start_pos": "178", "end_pos": "178" }, { "start_pos": "181", "end_pos": "181" }, { "start_pos": "188", "end_pos": "188" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "288", "end_pos": "288" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "83", "end_pos": "83" }, { "start_pos": "84", "end_pos": "84" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "87", "end_pos": "87" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "A0A8C2LVE3-1.172.172", "categories": [ "mutagenesis_flag" ] }, { "distance": 13, "direction": "downstream", "id": "A0A8C2LVE3-1.178.178", "categories": [ "mutagenesis_flag" ] }, { "distance": 10, "direction": "downstream", "id": "A0A8C2LVE3-1.181.181", "categories": [ "mutagenesis_flag" ] }, { "distance": 3, "direction": "downstream", "id": "A0A8C2LVE3-1.188.188", "categories": [ "mutagenesis_flag" ] }, { "distance": 2, "direction": "downstream", "id": "A0A8C2LVE3-1.189.189", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "downstream", "id": "A0A8C2LVE3-1.190.190", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "A0A8C2LVE3-1.288.288", "start_pos": 288, "end_pos": 288, "uniprot_canonical_ac": "A0A8C2LVE3-1", "length": 356, "uniprot_id": "HS2ST_CRIGR", "protein_name": "Heparan sulfate 2-O-sulfotransferase 1", "refseq_ac": "", "refseq_name": "", "gene_name": "HS2ST1", "gene_names_uniprotkb": "HS2ST1; LOC100760748", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [ { "title": "Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Xu D, Song D, Pedersen LC, Liu J", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "reference": [ { "type": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "crossref": [ { "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "LPRFFRGATDLYRTGKKSHL", "down_seq": "KTTEKKLPTKQTIAKLQQSD", "mutagenesis": [ { "sequence_org": "R", "sequence_mut": "A", "comment": "Severely abrogates catalytic activity but does not affect 3'-phosphoadenylyl sulfate substrate binding; may be involved in polysaccharide substrate binding specificity.", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" }, { "database": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] }, { "sequence_org": "R", "sequence_mut": "T", "comment": "Severely abrogates catalytic activity but does not affect 3'-phosphoadenylyl sulfate substrate binding; may be involved in polysaccharide substrate binding specificity.", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" }, { "database": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "108", "end_pos": "108" }, { "start_pos": "127", "end_pos": "127" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "164", "end_pos": "164" }, { "start_pos": "172", "end_pos": "172" }, { "start_pos": "178", "end_pos": "178" }, { "start_pos": "181", "end_pos": "181" }, { "start_pos": "188", "end_pos": "188" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "288", "end_pos": "288" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "83", "end_pos": "83" }, { "start_pos": "84", "end_pos": "84" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "87", "end_pos": "87" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "A0A8C2LVE3-1.80.80", "start_pos": 80, "end_pos": 80, "uniprot_canonical_ac": "A0A8C2LVE3-1", "length": 356, "uniprot_id": "HS2ST_CRIGR", "protein_name": "Heparan sulfate 2-O-sulfotransferase 1", "refseq_ac": "", "refseq_name": "", "gene_name": "HS2ST1", "gene_names_uniprotkb": "HS2ST1; LOC100760748", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [ { "title": "Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Xu D, Song D, Pedersen LC, Liu J", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "reference": [ { "type": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "crossref": [ { "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "DGPRQDAAVDEEEDIVIIYN", "down_seq": "VPKTASTSFTNIAYDLCAKN", "mutagenesis": [ { "sequence_org": "R", "sequence_mut": "A", "comment": "Severe reduction of catalytic activity but no effect on 3'-phosphoadenylyl sulfate substrate binding; probably disrupts binding to the carboxyl group of the iduronic acid of the polysaccharide substrate.", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" }, { "database": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "108", "end_pos": "108" }, { "start_pos": "127", "end_pos": "127" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "164", "end_pos": "164" }, { "start_pos": "172", "end_pos": "172" }, { "start_pos": "178", "end_pos": "178" }, { "start_pos": "181", "end_pos": "181" }, { "start_pos": "188", "end_pos": "188" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "288", "end_pos": "288" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "83", "end_pos": "83" }, { "start_pos": "84", "end_pos": "84" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "87", "end_pos": "87" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 3, "direction": "upstream", "id": "A0A8C2LVE3-1.83.83", "categories": [ "mutagenesis_flag" ] }, { "distance": 4, "direction": "upstream", "id": "A0A8C2LVE3-1.84.84", "categories": [ "mutagenesis_flag" ] }, { "distance": 6, "direction": "upstream", "id": "A0A8C2LVE3-1.86.86", "categories": [ "mutagenesis_flag" ] }, { "distance": 7, "direction": "upstream", "id": "A0A8C2LVE3-1.87.87", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "A0A8C2LVE3-1.83.83", "start_pos": 83, "end_pos": 83, "uniprot_canonical_ac": "A0A8C2LVE3-1", "length": 356, "uniprot_id": "HS2ST_CRIGR", "protein_name": "Heparan sulfate 2-O-sulfotransferase 1", "refseq_ac": "", "refseq_name": "", "gene_name": "HS2ST1", "gene_names_uniprotkb": "HS2ST1; LOC100760748", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [ { "title": "Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Xu D, Song D, Pedersen LC, Liu J", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "reference": [ { "type": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "crossref": [ { "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "RQDAAVDEEEDIVIIYNRVP", "down_seq": "TASTSFTNIAYDLCAKNRYH", "mutagenesis": [ { "sequence_org": "K", "sequence_mut": "A", "comment": "Loss of catalytic activity due to disruption of binding to the substrate 3'-phosphoadenylyl sulfate.", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" }, { "database": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "108", "end_pos": "108" }, { "start_pos": "127", "end_pos": "127" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "164", "end_pos": "164" }, { "start_pos": "172", "end_pos": "172" }, { "start_pos": "178", "end_pos": "178" }, { "start_pos": "181", "end_pos": "181" }, { "start_pos": "188", "end_pos": "188" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "288", "end_pos": "288" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "83", "end_pos": "83" }, { "start_pos": "84", "end_pos": "84" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "87", "end_pos": "87" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 3, "direction": "downstream", "id": "A0A8C2LVE3-1.80.80", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "upstream", "id": "A0A8C2LVE3-1.84.84", "categories": [ "mutagenesis_flag" ] }, { "distance": 3, "direction": "upstream", "id": "A0A8C2LVE3-1.86.86", "categories": [ "mutagenesis_flag" ] }, { "distance": 4, "direction": "upstream", "id": "A0A8C2LVE3-1.87.87", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "A0A8C2LVE3-1.84.84", "start_pos": 84, "end_pos": 84, "uniprot_canonical_ac": "A0A8C2LVE3-1", "length": 356, "uniprot_id": "HS2ST_CRIGR", "protein_name": "Heparan sulfate 2-O-sulfotransferase 1", "refseq_ac": "", "refseq_name": "", "gene_name": "HS2ST1", "gene_names_uniprotkb": "HS2ST1; LOC100760748", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [ { "title": "Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Xu D, Song D, Pedersen LC, Liu J", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "reference": [ { "type": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "crossref": [ { "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QDAAVDEEEDIVIIYNRVPK", "down_seq": "ASTSFTNIAYDLCAKNRYHV", "mutagenesis": [ { "sequence_org": "T", "sequence_mut": "A", "comment": "Severe reduction of catalytic activity due to disruption of binding to the substrate 3'-phosphoadenylyl sulfate.", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" }, { "database": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "108", "end_pos": "108" }, { "start_pos": "127", "end_pos": "127" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "164", "end_pos": "164" }, { "start_pos": "172", "end_pos": "172" }, { "start_pos": "178", "end_pos": "178" }, { "start_pos": "181", "end_pos": "181" }, { "start_pos": "188", "end_pos": "188" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "288", "end_pos": "288" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "83", "end_pos": "83" }, { "start_pos": "84", "end_pos": "84" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "87", "end_pos": "87" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "downstream", "id": "A0A8C2LVE3-1.80.80", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "downstream", "id": "A0A8C2LVE3-1.83.83", "categories": [ "mutagenesis_flag" ] }, { "distance": 2, "direction": "upstream", "id": "A0A8C2LVE3-1.86.86", "categories": [ "mutagenesis_flag" ] }, { "distance": 3, "direction": "upstream", "id": "A0A8C2LVE3-1.87.87", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "A0A8C2LVE3-1.86.86", "start_pos": 86, "end_pos": 86, "uniprot_canonical_ac": "A0A8C2LVE3-1", "length": 356, "uniprot_id": "HS2ST_CRIGR", "protein_name": "Heparan sulfate 2-O-sulfotransferase 1", "refseq_ac": "", "refseq_name": "", "gene_name": "HS2ST1", "gene_names_uniprotkb": "HS2ST1; LOC100760748", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [ { "title": "Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Xu D, Song D, Pedersen LC, Liu J", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "reference": [ { "type": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "crossref": [ { "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "AAVDEEEDIVIIYNRVPKTA", "down_seq": "TSFTNIAYDLCAKNRYHVLH", "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "Loss of catalytic activity due to disruption of binding to the substrate 3'-phosphoadenylyl sulfate.", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" }, { "database": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "108", "end_pos": "108" }, { "start_pos": "127", "end_pos": "127" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "164", "end_pos": "164" }, { "start_pos": "172", "end_pos": "172" }, { "start_pos": "178", "end_pos": "178" }, { "start_pos": "181", "end_pos": "181" }, { "start_pos": "188", "end_pos": "188" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "288", "end_pos": "288" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "83", "end_pos": "83" }, { "start_pos": "84", "end_pos": "84" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "87", "end_pos": "87" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 6, "direction": "downstream", "id": "A0A8C2LVE3-1.80.80", "categories": [ "mutagenesis_flag" ] }, { "distance": 3, "direction": "downstream", "id": "A0A8C2LVE3-1.83.83", "categories": [ "mutagenesis_flag" ] }, { "distance": 2, "direction": "downstream", "id": "A0A8C2LVE3-1.84.84", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "upstream", "id": "A0A8C2LVE3-1.87.87", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "A0A8C2LVE3-1.87.87", "start_pos": 87, "end_pos": 87, "uniprot_canonical_ac": "A0A8C2LVE3-1", "length": 356, "uniprot_id": "HS2ST_CRIGR", "protein_name": "Heparan sulfate 2-O-sulfotransferase 1", "refseq_ac": "", "refseq_name": "", "gene_name": "HS2ST1", "gene_names_uniprotkb": "HS2ST1; LOC100760748", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [ { "title": "Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Xu D, Song D, Pedersen LC, Liu J", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" } ], "reference": [ { "type": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "crossref": [ { "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AVDEEEDIVIIYNRVPKTAS", "down_seq": "SFTNIAYDLCAKNRYHVLHI", "mutagenesis": [ { "sequence_org": "T", "sequence_mut": "A", "comment": "Severe reduction of catalytic activity due to disruption of binding to the substrate 3'-phosphoadenylyl sulfate.", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LVE3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LVE3" }, { "database": "PubMed", "id": "17227754", "url": "https://glygen.org/publication/PubMed/17227754" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "108", "end_pos": "108" }, { "start_pos": "127", "end_pos": "127" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "164", "end_pos": "164" }, { "start_pos": "172", "end_pos": "172" }, { "start_pos": "178", "end_pos": "178" }, { "start_pos": "181", "end_pos": "181" }, { "start_pos": "188", "end_pos": "188" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "288", "end_pos": "288" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "83", "end_pos": "83" }, { "start_pos": "84", "end_pos": "84" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "87", "end_pos": "87" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 7, "direction": "downstream", "id": "A0A8C2LVE3-1.80.80", "categories": [ "mutagenesis_flag" ] }, { "distance": 4, "direction": "downstream", "id": "A0A8C2LVE3-1.83.83", "categories": [ "mutagenesis_flag" ] }, { "distance": 3, "direction": "downstream", "id": "A0A8C2LVE3-1.84.84", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "downstream", "id": "A0A8C2LVE3-1.86.86", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "A2V7M9-1.40.40", "start_pos": 40, "end_pos": 40, "uniprot_canonical_ac": "A2V7M9-1", "length": 320, "uniprot_id": "PGAP3_CRIGR", "protein_name": "GPI-specific phospholipase A2-like PGAP3", "refseq_ac": "NP_001233642", "refseq_name": "GPI-specific phospholipase A2-like PGAP3 precursor", "gene_name": "PGAP3", "gene_names_uniprotkb": "PGAP3; PERLD1", "gene_names_refseq": "PERLD1; Pgap3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A2V7M9", "url": "https://www.uniprot.org/uniprotkb/A2V7M9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A2V7M9", "url": "https://www.uniprot.org/uniprotkb/A2V7M9", "database": "UniProtKB", "categories": [ "Protein" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "GSQGDREPVYRDCVLRCEER", "down_seq": "CSGDALKHFRSLQPIYMSLA", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn40", "evidence": [ { "id": "A2V7M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2V7M9#ptm_processing" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "40", "end_pos": "40" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7GV10-1.350.350", "start_pos": 350, "end_pos": 350, "uniprot_canonical_ac": "A0A3L7GV10-1", "length": 727, "uniprot_id": "A0A3L7GV10_CRIGR", "protein_name": "Ubiquitin carboxyl-terminal hydrolase", "refseq_ac": "XP_003495340", "refseq_name": "ubiquitin carboxyl-terminal hydrolase BAP1 isoform X1", "gene_name": "Bap1", "gene_names_uniprotkb": "Bap1", "gene_names_refseq": "Bap1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7GV10", "url": "https://www.uniprot.org/uniprotkb/A0A3L7GV10" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SKSKLVVKPPGSLNGVPPNP", "down_seq": "PIVQRLPAFLDNHNYAKSPM", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr350", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "350", "end_pos": "350" }, { "start_pos": "485", "end_pos": "485" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7GV10-1.485.485", "start_pos": 485, "end_pos": 485, "uniprot_canonical_ac": "A0A3L7GV10-1", "length": 727, "uniprot_id": "A0A3L7GV10_CRIGR", "protein_name": "Ubiquitin carboxyl-terminal hydrolase", "refseq_ac": "XP_003495340", "refseq_name": "ubiquitin carboxyl-terminal hydrolase BAP1 isoform X1", "gene_name": "Bap1", "gene_names_uniprotkb": "Bap1", "gene_names_refseq": "Bap1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7GV10", "url": "https://www.uniprot.org/uniprotkb/A0A3L7GV10" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TSSGAGSPAVAVPTHSQPSP", "down_seq": "PSNESTDTASEIGSAFNSPL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr485", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "350", "end_pos": "350" }, { "start_pos": "485", "end_pos": "485" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7H5T4-1.306.306", "start_pos": 306, "end_pos": 306, "uniprot_canonical_ac": "A0A3L7H5T4-1", "length": 322, "uniprot_id": "A0A3L7H5T4_CRIGR", "protein_name": "mRNA decay activator protein ZFP36", "refseq_ac": "XP_027286301", "refseq_name": "mRNA decay activator protein ZFP36 isoform X2", "gene_name": "Zfp36", "gene_names_uniprotkb": "Zfp36", "gene_names_refseq": "Zfp36", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7H5T4", "url": "https://www.uniprot.org/uniprotkb/A0A3L7H5T4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SLGGSDSPVFEAGVFGPPPP", "down_seq": "APPRRLPIFNRISVSE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr306", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "306", "end_pos": "306" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7H9W7-1.176.176", "start_pos": 176, "end_pos": 176, "uniprot_canonical_ac": "A0A3L7H9W7-1", "length": 480, "uniprot_id": "A0A3L7H9W7_CRIGR", "protein_name": "Endothelial transcription factor GATA-2", "refseq_ac": "XP_027284488", "refseq_name": "endothelial transcription factor GATA-2", "gene_name": "Gata2", "gene_names_uniprotkb": "Gata2", "gene_names_refseq": "Gata2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7H9W7", "url": "https://www.uniprot.org/uniprotkb/A0A3L7H9W7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VASLTPTAAHSGSHLFGFPP", "down_seq": "PPKEVSPDPSTTGAASPASS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr176", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "176", "end_pos": "176" }, { "start_pos": "455", "end_pos": "455" }, { "start_pos": "457", "end_pos": "457" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7H9W7-1.455.455", "start_pos": 455, "end_pos": 455, "uniprot_canonical_ac": "A0A3L7H9W7-1", "length": 480, "uniprot_id": "A0A3L7H9W7_CRIGR", "protein_name": "Endothelial transcription factor GATA-2", "refseq_ac": "XP_027284488", "refseq_name": "endothelial transcription factor GATA-2", "gene_name": "Gata2", "gene_names_uniprotkb": "Gata2", "gene_names_refseq": "Gata2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7H9W7", "url": "https://www.uniprot.org/uniprotkb/A0A3L7H9W7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GHMAPVGHLPPFSHSGHILP", "down_seq": "PTPIHPSSSLSFGHPHPSSM", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr455", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "176", "end_pos": "176" }, { "start_pos": "455", "end_pos": "455" }, { "start_pos": "457", "end_pos": "457" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "upstream", "id": "A0A3L7H9W7-1.457.457", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7H9W7-1.457.457", "start_pos": 457, "end_pos": 457, "uniprot_canonical_ac": "A0A3L7H9W7-1", "length": 480, "uniprot_id": "A0A3L7H9W7_CRIGR", "protein_name": "Endothelial transcription factor GATA-2", "refseq_ac": "XP_027284488", "refseq_name": "endothelial transcription factor GATA-2", "gene_name": "Gata2", "gene_names_uniprotkb": "Gata2", "gene_names_refseq": "Gata2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7H9W7", "url": "https://www.uniprot.org/uniprotkb/A0A3L7H9W7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MAPVGHLPPFSHSGHILPTP", "down_seq": "PIHPSSSLSFGHPHPSSMVT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr457", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "176", "end_pos": "176" }, { "start_pos": "455", "end_pos": "455" }, { "start_pos": "457", "end_pos": "457" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "downstream", "id": "A0A3L7H9W7-1.455.455", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7HCJ3-1.25.25", "start_pos": 25, "end_pos": 25, "uniprot_canonical_ac": "A0A3L7HCJ3-1", "length": 509, "uniprot_id": "A0A3L7HCJ3_CRIGR", "protein_name": "Transcription factor SOX-9", "refseq_ac": "XP_027281584", "refseq_name": "transcription factor SOX-9 isoform X2", "gene_name": "Sox9", "gene_names_uniprotkb": "Sox9", "gene_names_refseq": "Sox9", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7HCJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3L7HCJ3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DPFMKMTDEQEKGLSGAPSP", "down_seq": "MSEDSAGSPCPSGSGSDTEN", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr25", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "25", "end_pos": "25" }, { "start_pos": "327", "end_pos": "327" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7HCJ3-1.327.327", "start_pos": 327, "end_pos": 327, "uniprot_canonical_ac": "A0A3L7HCJ3-1", "length": 509, "uniprot_id": "A0A3L7HCJ3_CRIGR", "protein_name": "Transcription factor SOX-9", "refseq_ac": "XP_027281584", "refseq_name": "transcription factor SOX-9 isoform X2", "gene_name": "Sox9", "gene_names_uniprotkb": "Sox9", "gene_names_refseq": "Sox9", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7HCJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3L7HCJ3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PATHGQVTYTGSYGISSTAA", "down_seq": "PATAGHVWLSKQQAPPPPPQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr327", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "25", "end_pos": "25" }, { "start_pos": "327", "end_pos": "327" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7HHE1-1.22.22", "start_pos": 22, "end_pos": 22, "uniprot_canonical_ac": "A0A3L7HHE1-1", "length": 390, "uniprot_id": "A0A3L7HHE1_CRIGR", "protein_name": "ATP-sensitive inward rectifier potassium channel 11", "refseq_ac": "XP_027276351", "refseq_name": "ATP-sensitive inward rectifier potassium channel 11 isoform X2", "gene_name": "Kcnj11", "gene_names_uniprotkb": "Kcnj11", "gene_names_refseq": "Kcnj11", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7HHE1", "url": "https://www.uniprot.org/uniprotkb/A0A3L7HHE1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LSRKGIIPEEYVLTRLAEDP", "down_seq": "EPRYRARERRARFVSKKGNC", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr22", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "22", "end_pos": "22" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7HM64-1.207.207", "start_pos": 207, "end_pos": 207, "uniprot_canonical_ac": "A0A3L7HM64-1", "length": 473, "uniprot_id": "A0A3L7HM64_CRIGR", "protein_name": "P2X purinoceptor", "refseq_ac": "XP_027271670", "refseq_name": "P2X purinoceptor 2 isoform X1", "gene_name": "P2rx2", "gene_names_uniprotkb": "P2rx2", "gene_names_refseq": "P2rx2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7HM64", "url": "https://www.uniprot.org/uniprotkb/A0A3L7HM64" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A3L7HM64", "url": "https://www.uniprot.org/uniprotkb/A0A3L7HM64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR005713-3", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005713-3", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "AWCPVEDGTTENQFLGKMAP", "down_seq": "FTILIKNNIHYPKFKFSKGN", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn207", "evidence": [ { "id": "A0A3L7HM64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3L7HM64#ptm_processing" }, { "id": "PIRSR005713-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005713-3" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "207", "end_pos": "207" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7HRU5-1.17.17", "start_pos": 17, "end_pos": 17, "uniprot_canonical_ac": "A0A3L7HRU5-1", "length": 280, "uniprot_id": "A0A3L7HRU5_CRIGR", "protein_name": "Transcription factor HES-1 isoform X2", "refseq_ac": "XP_007646558", "refseq_name": "transcription factor HES-1 isoform X1", "gene_name": "Hes1", "gene_names_uniprotkb": "Hes1", "gene_names_refseq": "Hes1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7HRU5", "url": "https://www.uniprot.org/uniprotkb/A0A3L7HRU5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MPADIMEKNSSSPVAA", "down_seq": "PASVNTTPDKPKTASEHRKS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr17", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "17", "end_pos": "17" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7HTS8-1.34.34", "start_pos": 34, "end_pos": 34, "uniprot_canonical_ac": "A0A3L7HTS8-1", "length": 378, "uniprot_id": "A0A3L7HTS8_CRIGR", "protein_name": "Forkhead box protein F1 isoform X2", "refseq_ac": "XP_027266516", "refseq_name": "forkhead box protein F1 isoform X2", "gene_name": "Foxf1", "gene_names_uniprotkb": "Foxf1", "gene_names_refseq": "Foxf1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7HTS8", "url": "https://www.uniprot.org/uniprotkb/A0A3L7HTS8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GTGGGGGAGSQAMDPAAAGP", "down_seq": "KAKKTNAGVRRPEKPPYSYI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr34", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "34", "end_pos": "34" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7HUF6-1.575.575", "start_pos": 575, "end_pos": 575, "uniprot_canonical_ac": "A0A3L7HUF6-1", "length": 638, "uniprot_id": "A0A3L7HUF6_CRIGR", "protein_name": "Epithelial sodium channel subunit beta", "refseq_ac": "XP_027266048", "refseq_name": "amiloride-sensitive sodium channel subunit beta isoform X2", "gene_name": "Scnn1b", "gene_names_uniprotkb": "Scnn1b", "gene_names_refseq": "Scnn1b", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7HUF6", "url": "https://www.uniprot.org/uniprotkb/A0A3L7HUF6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VSCKGLRRKRPQAPYTGPPP", "down_seq": "VAELVEAHTNFGFQPDTTNH", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr575", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "575", "end_pos": "575" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7HY07-1.277.277", "start_pos": 277, "end_pos": 277, "uniprot_canonical_ac": "A0A3L7HY07-1", "length": 467, "uniprot_id": "A0A3L7HY07_CRIGR", "protein_name": "Alpha-2A adrenergic receptor", "refseq_ac": "XP_035298950", "refseq_name": "alpha-2A adrenergic receptor isoform X2", "gene_name": "Adra2a", "gene_names_uniprotkb": "Adra2a", "gene_names_refseq": "Adra2a", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7HY07", "url": "https://www.uniprot.org/uniprotkb/A0A3L7HY07" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PPGGTDRRPNGLGPERGAGP", "down_seq": "GAEAEPLPTQLNGAPGEPAP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr277", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "277", "end_pos": "277" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7HYR4-1.47.47", "start_pos": 47, "end_pos": 47, "uniprot_canonical_ac": "A0A3L7HYR4-1", "length": 271, "uniprot_id": "A0A3L7HYR4_CRIGR", "protein_name": "Hematopoietically-expressed homeobox protein HHEX", "refseq_ac": "XP_027263259", "refseq_name": "hematopoietically-expressed homeobox protein HHEX isoform X2", "gene_name": "Hhex", "gene_names_uniprotkb": "Hhex", "gene_names_refseq": "Hhex", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7HYR4", "url": "https://www.uniprot.org/uniprotkb/A0A3L7HYR4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PAHPTPFYIDDILGRGPAAP", "down_seq": "PTPTLPSPNSSFTSLVSSYR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr47", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "47", "end_pos": "47" }, { "start_pos": "49", "end_pos": "49" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "upstream", "id": "A0A3L7HYR4-1.49.49", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7HYR4-1.49.49", "start_pos": 49, "end_pos": 49, "uniprot_canonical_ac": "A0A3L7HYR4-1", "length": 271, "uniprot_id": "A0A3L7HYR4_CRIGR", "protein_name": "Hematopoietically-expressed homeobox protein HHEX", "refseq_ac": "XP_027263259", "refseq_name": "hematopoietically-expressed homeobox protein HHEX isoform X2", "gene_name": "Hhex", "gene_names_uniprotkb": "Hhex", "gene_names_refseq": "Hhex", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7HYR4", "url": "https://www.uniprot.org/uniprotkb/A0A3L7HYR4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "HPTPFYIDDILGRGPAAPTP", "down_seq": "PTLPSPNSSFTSLVSSYRTP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr49", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "47", "end_pos": "47" }, { "start_pos": "49", "end_pos": "49" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "downstream", "id": "A0A3L7HYR4-1.47.47", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7I7Z6-1.519.519", "start_pos": 519, "end_pos": 519, "uniprot_canonical_ac": "A0A3L7I7Z6-1", "length": 593, "uniprot_id": "A0A3L7I7Z6_CRIGR", "protein_name": "Endoribonuclease ZC3H12A", "refseq_ac": "XP_003502297", "refseq_name": "endoribonuclease ZC3H12A", "gene_name": "Zc3h12a", "gene_names_uniprotkb": "Zc3h12a", "gene_names_refseq": "Zc3h12a", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7I7Z6", "url": "https://www.uniprot.org/uniprotkb/A0A3L7I7Z6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QPPTFPAREYWSEPYPLPSP", "down_seq": "PVLQEPQRPSPGASRGPWDR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr519", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "519", "end_pos": "519" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7I8K8-1.125.125", "start_pos": 125, "end_pos": 125, "uniprot_canonical_ac": "A0A3L7I8K8-1", "length": 351, "uniprot_id": "A0A3L7I8K8_CRIGR", "protein_name": "Protein Wnt", "refseq_ac": "XP_027255556", "refseq_name": "protein Wnt-4 isoform X3", "gene_name": "Wnt4", "gene_names_uniprotkb": "Wnt4", "gene_names_refseq": "Wnt4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7I8K8", "url": "https://www.uniprot.org/uniprotkb/A0A3L7I8K8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GTREAAFVYAISSAGVAFAV", "down_seq": "RACSSGELEKCGCDRTVHGV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr125", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "125", "end_pos": "125" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7ID99-1.237.237", "start_pos": 237, "end_pos": 237, "uniprot_canonical_ac": "A0A3L7ID99-1", "length": 396, "uniprot_id": "A0A3L7ID99_CRIGR", "protein_name": "Hedgehog protein", "refseq_ac": "XP_027252302", "refseq_name": "desert hedgehog protein isoform X2", "gene_name": "Dhh", "gene_names_uniprotkb": "Dhh", "gene_names_refseq": "Dhh", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7ID99", "url": "https://www.uniprot.org/uniprotkb/A0A3L7ID99" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RELHRGDWVLAADAAGRVVP", "down_seq": "PVLLFLDRDLQRRASFVAVE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr237", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "237", "end_pos": "237" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7INC1-1.109.109", "start_pos": 109, "end_pos": 109, "uniprot_canonical_ac": "A0A3L7INC1-1", "length": 359, "uniprot_id": "A0A3L7INC1_CRIGR", "protein_name": "N-acylethanolamine-hydrolyzing acid amidase", "refseq_ac": "XP_003512797", "refseq_name": "N-acylethanolamine-hydrolyzing acid amidase", "gene_name": "Naaa", "gene_names_uniprotkb": "Naaa", "gene_names_refseq": "Naaa", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7INC1", "url": "https://www.uniprot.org/uniprotkb/A0A3L7INC1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A3L7INC1", "url": "https://www.uniprot.org/uniprotkb/A0A3L7INC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR017632-2", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR017632-2", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "VESFLPQPFTDEIRGMCNFL", "down_seq": "LSLADGILVNLAYEASAFCT", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn109", "evidence": [ { "id": "A0A3L7INC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3L7INC1#ptm_processing" }, { "id": "PIRSR017632-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR017632-2" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "109", "end_pos": "109" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "335", "end_pos": "335" }, { "start_pos": "39", "end_pos": "39" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7INC1-1.311.311", "start_pos": 311, "end_pos": 311, "uniprot_canonical_ac": "A0A3L7INC1-1", "length": 359, "uniprot_id": "A0A3L7INC1_CRIGR", "protein_name": "N-acylethanolamine-hydrolyzing acid amidase", "refseq_ac": "XP_003512797", "refseq_name": "N-acylethanolamine-hydrolyzing acid amidase", "gene_name": "Naaa", "gene_names_uniprotkb": "Naaa", "gene_names_refseq": "Naaa", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7INC1", "url": "https://www.uniprot.org/uniprotkb/A0A3L7INC1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A3L7INC1", "url": "https://www.uniprot.org/uniprotkb/A0A3L7INC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR017632-2", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR017632-2", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "DHWKPVPKRDDRRTPAIKAL", "down_seq": "ATGQAHISLEALFQVLSVFP", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn311", "evidence": [ { "id": "A0A3L7INC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3L7INC1#ptm_processing" }, { "id": "PIRSR017632-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR017632-2" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "109", "end_pos": "109" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "335", "end_pos": "335" }, { "start_pos": "39", "end_pos": "39" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7INC1-1.335.335", "start_pos": 335, "end_pos": 335, "uniprot_canonical_ac": "A0A3L7INC1-1", "length": 359, "uniprot_id": "A0A3L7INC1_CRIGR", "protein_name": "N-acylethanolamine-hydrolyzing acid amidase", "refseq_ac": "XP_003512797", "refseq_name": "N-acylethanolamine-hydrolyzing acid amidase", "gene_name": "Naaa", "gene_names_uniprotkb": "Naaa", "gene_names_refseq": "Naaa", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7INC1", "url": "https://www.uniprot.org/uniprotkb/A0A3L7INC1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A3L7INC1", "url": "https://www.uniprot.org/uniprotkb/A0A3L7INC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR017632-2", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR017632-2", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "QAHISLEALFQVLSVFPVYN", "down_seq": "CTIYTTVMSAAEPDKYMTRV", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn335", "evidence": [ { "id": "A0A3L7INC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3L7INC1#ptm_processing" }, { "id": "PIRSR017632-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR017632-2" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "109", "end_pos": "109" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "335", "end_pos": "335" }, { "start_pos": "39", "end_pos": "39" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A3L7INC1-1.39.39", "start_pos": 39, "end_pos": 39, "uniprot_canonical_ac": "A0A3L7INC1-1", "length": 359, "uniprot_id": "A0A3L7INC1_CRIGR", "protein_name": "N-acylethanolamine-hydrolyzing acid amidase", "refseq_ac": "XP_003512797", "refseq_name": "N-acylethanolamine-hydrolyzing acid amidase", "gene_name": "Naaa", "gene_names_uniprotkb": "Naaa", "gene_names_refseq": "Naaa", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A3L7INC1", "url": "https://www.uniprot.org/uniprotkb/A0A3L7INC1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A3L7INC1", "url": "https://www.uniprot.org/uniprotkb/A0A3L7INC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR017632-2", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR017632-2", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "LLLLPGPWLSTGVPGAPPLF", "down_seq": "VSMDAAPEQRWLPMLQHYDP", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn39", "evidence": [ { "id": "A0A3L7INC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3L7INC1#ptm_processing" }, { "id": "PIRSR017632-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR017632-2" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "109", "end_pos": "109" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "335", "end_pos": "335" }, { "start_pos": "39", "end_pos": "39" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2L7E1-1.37.37", "start_pos": 37, "end_pos": 37, "uniprot_canonical_ac": "A0A8C2L7E1-1", "length": 442, "uniprot_id": "A0A8C2L7E1_CRIGR", "protein_name": "Endothelin receptor type B", "refseq_ac": "XP_007642277", "refseq_name": "endothelin receptor type B", "gene_name": "Ednrb", "gene_names_uniprotkb": "Ednrb", "gene_names_refseq": "Ednrb", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2L7E1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2L7E1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LACGLLGVWGEERGFPPAQA", "down_seq": "PSLLGTREVMTPPTKTSWTK", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr37", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "37", "end_pos": "37" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2L8A2-1.33.33", "start_pos": 33, "end_pos": 33, "uniprot_canonical_ac": "A0A8C2L8A2-1", "length": 343, "uniprot_id": "A0A8C2L8A2_CRIGR", "protein_name": "Bis(monoacylglycero)phosphate synthase CLN5", "refseq_ac": "XP_027249788", "refseq_name": "ceroid-lipofuscinosis neuronal protein 5 isoform X2", "gene_name": "Cln5", "gene_names_uniprotkb": "Cln5", "gene_names_refseq": "Cln5", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2L8A2", "url": "https://www.uniprot.org/uniprotkb/A0A8C2L8A2" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "WPLALALAGLGLTATLGAAP", "down_seq": "SGRRWPVPYKRFSFRPKPDP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr33", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "33", "end_pos": "33" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LE14-1.267.267", "start_pos": 267, "end_pos": 267, "uniprot_canonical_ac": "A0A8C2LE14-1", "length": 1047, "uniprot_id": "A0A8C2LE14_CRIGR", "protein_name": "Guanylate cyclase", "refseq_ac": "XP_027259029", "refseq_name": "atrial natriuretic peptide receptor 2 isoform X2", "gene_name": "Npr2", "gene_names_uniprotkb": "Npr2", "gene_names_refseq": "Npr2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LE14", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LE14" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "NGDYVFFYLDVFGESLRAGP", "down_seq": "RATGRPWQDNRTQEQAQALR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr267", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "267", "end_pos": "267" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LGN7-1.238.238", "start_pos": 238, "end_pos": 238, "uniprot_canonical_ac": "A0A8C2LGN7-1", "length": 439, "uniprot_id": "A0A8C2LGN7_CRIGR", "protein_name": "Transcription factor SOX", "refseq_ac": "XP_027265119", "refseq_name": "transcription factor SOX-4 isoform X2", "gene_name": "Sox4", "gene_names_uniprotkb": "Sox4", "gene_names_refseq": "Sox4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LGN7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LGN7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ALLPLGEPTAVYKVRTPNAA", "down_seq": "PATSSSPTSTLATPAKHPAD", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr238", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "238", "end_pos": "238" }, { "start_pos": "251", "end_pos": "251" }, { "start_pos": "35", "end_pos": "35" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 13, "direction": "upstream", "id": "A0A8C2LGN7-1.251.251", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LGN7-1.251.251", "start_pos": 251, "end_pos": 251, "uniprot_canonical_ac": "A0A8C2LGN7-1", "length": 439, "uniprot_id": "A0A8C2LGN7_CRIGR", "protein_name": "Transcription factor SOX", "refseq_ac": "XP_027265119", "refseq_name": "transcription factor SOX-4 isoform X2", "gene_name": "Sox4", "gene_names_uniprotkb": "Sox4", "gene_names_refseq": "Sox4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LGN7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LGN7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VRTPNAATPATSSSPTSTLA", "down_seq": "PAKHPADKKVKRVYLFGSLG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr251", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "238", "end_pos": "238" }, { "start_pos": "251", "end_pos": "251" }, { "start_pos": "35", "end_pos": "35" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 13, "direction": "downstream", "id": "A0A8C2LGN7-1.238.238", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LGN7-1.35.35", "start_pos": 35, "end_pos": 35, "uniprot_canonical_ac": "A0A8C2LGN7-1", "length": 439, "uniprot_id": "A0A8C2LGN7_CRIGR", "protein_name": "Transcription factor SOX", "refseq_ac": "XP_027265119", "refseq_name": "transcription factor SOX-4 isoform X2", "gene_name": "Sox4", "gene_names_uniprotkb": "Sox4", "gene_names_refseq": "Sox4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LGN7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LGN7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LAGESSDSGAGLELGIASSP", "down_seq": "PGSTASTGGKADDPSWCKTP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr35", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "238", "end_pos": "238" }, { "start_pos": "251", "end_pos": "251" }, { "start_pos": "35", "end_pos": "35" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LHG5-1.1413.1413", "start_pos": 1413, "end_pos": 1413, "uniprot_canonical_ac": "A0A8C2LHG5-1", "length": 2214, "uniprot_id": "A0A8C2LHG5_CRIGR", "protein_name": "Sortilin-related receptor", "refseq_ac": "XP_027267676", "refseq_name": "sortilin-related receptor isoform X3", "gene_name": "Sorl1", "gene_names_uniprotkb": "Sorl1", "gene_names_refseq": "Sorl1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LHG5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LHG5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DCGDWSDEKDCGDSHVFPSP", "down_seq": "PGPSTCLPNYFRCSSGTCVM", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1413", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1413", "end_pos": "1413" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LJN1-1.628.628", "start_pos": 628, "end_pos": 628, "uniprot_canonical_ac": "A0A8C2LJN1-1", "length": 1666, "uniprot_id": "A0A8C2LJN1_CRIGR", "protein_name": "Complement C3", "refseq_ac": "XP_027272591", "refseq_name": "complement C3", "gene_name": "C3", "gene_names_uniprotkb": "C3", "gene_names_refseq": "C3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LJN1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LJN1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "KNKLTQSKIWDVVEKADIGC", "down_seq": "PGSGKDYAGVFMDAGLAFKT", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr628", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "628", "end_pos": "628" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LLJ5-1.1093.1093", "start_pos": 1093, "end_pos": 1093, "uniprot_canonical_ac": "A0A8C2LLJ5-1", "length": 1152, "uniprot_id": "A0A8C2LLJ5_CRIGR", "protein_name": "Tyrosine-protein kinase", "refseq_ac": "XP_003508184", "refseq_name": "tyrosine-protein kinase JAK1 isoform X1", "gene_name": "Jak1", "gene_names_uniprotkb": "Jak1", "gene_names_refseq": "Jak1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LLJ5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LLJ5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LTYCDSDFSPMALFLKMIGP", "down_seq": "HGQMTVTRLVNTLKEGKRLP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1093", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1093", "end_pos": "1093" }, { "start_pos": "812", "end_pos": "812" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LLJ5-1.812.812", "start_pos": 812, "end_pos": 812, "uniprot_canonical_ac": "A0A8C2LLJ5-1", "length": 1152, "uniprot_id": "A0A8C2LLJ5_CRIGR", "protein_name": "Tyrosine-protein kinase", "refseq_ac": "XP_003508184", "refseq_name": "tyrosine-protein kinase JAK1 isoform X1", "gene_name": "Jak1", "gene_names_uniprotkb": "Jak1", "gene_names_refseq": "Jak1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LLJ5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LLJ5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LKDKTLVEKERFYESRCRPV", "down_seq": "PSCKELADLMTRCMNYDPSQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr812", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1093", "end_pos": "1093" }, { "start_pos": "812", "end_pos": "812" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LLQ4-1.101.101", "start_pos": 101, "end_pos": 101, "uniprot_canonical_ac": "A0A8C2LLQ4-1", "length": 813, "uniprot_id": "A0A8C2LLQ4_CRIGR", "protein_name": "Histone acetyltransferase", "refseq_ac": "XP_027250379", "refseq_name": "histone acetyltransferase KAT2B isoform X2", "gene_name": "Kat2b", "gene_names_uniprotkb": "Kat2b", "gene_names_refseq": "Kat2b", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LLQ4", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LLQ4" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ACKAEESCKCNGWKNPNPSP", "down_seq": "PPRADLQQIIVSLTESCRSC", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr101", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "101", "end_pos": "101" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LMX3-1.363.363", "start_pos": 363, "end_pos": 363, "uniprot_canonical_ac": "A0A8C2LMX3-1", "length": 861, "uniprot_id": "A0A8C2LMX3_CRIGR", "protein_name": "Semaphorin-4D", "refseq_ac": "XP_035298863", "refseq_name": "semaphorin-4D", "gene_name": "Sema4d", "gene_names_uniprotkb": "Sema4d", "gene_names_refseq": "Sema4d", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LMX3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LMX3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QSATVEQSHTKWVRYNGPVP", "down_seq": "PRPGACIDTEARAANYTSSL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr363", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "363", "end_pos": "363" }, { "start_pos": "683", "end_pos": "683" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LMX3-1.683.683", "start_pos": 683, "end_pos": 683, "uniprot_canonical_ac": "A0A8C2LMX3-1", "length": 861, "uniprot_id": "A0A8C2LMX3_CRIGR", "protein_name": "Semaphorin-4D", "refseq_ac": "XP_035298863", "refseq_name": "semaphorin-4D", "gene_name": "Sema4d", "gene_names_uniprotkb": "Sema4d", "gene_names_refseq": "Sema4d", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LMX3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LMX3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EGSRITSKMPVASTQGSSPP", "down_seq": "PALWATSPRAATLPPKSSST", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr683", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "363", "end_pos": "363" }, { "start_pos": "683", "end_pos": "683" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LP58-1.166.166", "start_pos": 166, "end_pos": 166, "uniprot_canonical_ac": "A0A8C2LP58-1", "length": 269, "uniprot_id": "A0A8C2LP58_CRIGR", "protein_name": "Cbp/p300-interacting transactivator 2", "refseq_ac": "XP_027257769", "refseq_name": "cbp/p300-interacting transactivator 2 isoform X2", "gene_name": "Cited2", "gene_names_uniprotkb": "Cited2", "gene_names_refseq": "Cited2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LP58", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LP58" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MNGTNQHFRDCNPKHSGGSS", "down_seq": "PGGAGGSGTPGGSGSTSGGA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr166", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "166", "end_pos": "166" }, { "start_pos": "175", "end_pos": "175" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 9, "direction": "upstream", "id": "A0A8C2LP58-1.175.175", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LP58-1.175.175", "start_pos": 175, "end_pos": 175, "uniprot_canonical_ac": "A0A8C2LP58-1", "length": 269, "uniprot_id": "A0A8C2LP58_CRIGR", "protein_name": "Cbp/p300-interacting transactivator 2", "refseq_ac": "XP_027257769", "refseq_name": "cbp/p300-interacting transactivator 2 isoform X2", "gene_name": "Cited2", "gene_names_uniprotkb": "Cited2", "gene_names_refseq": "Cited2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LP58", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LP58" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DCNPKHSGGSSTPGGAGGSG", "down_seq": "PGGSGSTSGGAGGSGAGGSG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr175", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "166", "end_pos": "166" }, { "start_pos": "175", "end_pos": "175" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 9, "direction": "downstream", "id": "A0A8C2LP58-1.166.166", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LP72-1.95.95", "start_pos": 95, "end_pos": 95, "uniprot_canonical_ac": "A0A8C2LP72-1", "length": 336, "uniprot_id": "A0A8C2LP72_CRIGR", "protein_name": "Potassium channel subfamily K member", "refseq_ac": "XP_035293316", "refseq_name": "potassium channel subfamily K member 1", "gene_name": "Kcnk1", "gene_names_uniprotkb": "Kcnk1", "gene_names_refseq": "Kcnk1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LP72", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LP72" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A8C2LP72", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LP72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR038061-1", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038061-1", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "LEQFLGRVLEASNYGVSVLS", "down_seq": "ASGNWNWDFTSALFFASTVL", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn95", "evidence": [ { "id": "A0A8C2LP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LP72#ptm_processing" }, { "id": "PIRSR038061-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038061-1" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "95", "end_pos": "95" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LQD3-1.545.545", "start_pos": 545, "end_pos": 545, "uniprot_canonical_ac": "A0A8C2LQD3-1", "length": 680, "uniprot_id": "A0A8C2LQD3_CRIGR", "protein_name": "Tumor protein 63 (p63)", "refseq_ac": "XP_035300559", "refseq_name": "tumor protein 63 isoform X1", "gene_name": "Tp63", "gene_names_uniprotkb": "Tp63", "gene_names_refseq": "Tp63", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LQD3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LQD3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LPPPLSMPSTSHCTPPPPYP", "down_seq": "DCSIVSFLARLGCSSCLDYF", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr545", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "545", "end_pos": "545" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LQS3-1.221.221", "start_pos": 221, "end_pos": 221, "uniprot_canonical_ac": "A0A8C2LQS3-1", "length": 419, "uniprot_id": "A0A8C2LQS3_CRIGR", "protein_name": "Transcription factor SOX-17 isoform X1", "refseq_ac": "XP_027254730", "refseq_name": "transcription factor SOX-17 isoform X1", "gene_name": "LOC113833792", "gene_names_uniprotkb": "LOC113833792", "gene_names_refseq": "LOC113833792", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LQS3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LQS3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AHYRDCQGLGAPALDGYPLP", "down_seq": "PDTSPLDGVEQDPAFFAAPL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr221", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "221", "end_pos": "221" }, { "start_pos": "54", "end_pos": "54" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LQS3-1.54.54", "start_pos": 54, "end_pos": 54, "uniprot_canonical_ac": "A0A8C2LQS3-1", "length": 419, "uniprot_id": "A0A8C2LQS3_CRIGR", "protein_name": "Transcription factor SOX-17 isoform X1", "refseq_ac": "XP_027254730", "refseq_name": "transcription factor SOX-17 isoform X1", "gene_name": "LOC113833792", "gene_names_uniprotkb": "LOC113833792", "gene_names_refseq": "LOC113833792", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LQS3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LQS3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ESLSPLGDVKVKGEVVASSG", "down_seq": "PAGTSSRAKAESRIRRPMNA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr54", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "221", "end_pos": "221" }, { "start_pos": "54", "end_pos": "54" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LR00-1.120.120", "start_pos": 120, "end_pos": 120, "uniprot_canonical_ac": "A0A8C2LR00-1", "length": 1686, "uniprot_id": "A0A8C2LR00_CRIGR", "protein_name": "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha", "refseq_ac": "XP_003504858", "refseq_name": "phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha", "gene_name": "Pik3c2a", "gene_names_uniprotkb": "Pik3c2a", "gene_names_refseq": "Pik3c2a", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LR00", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LR00" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LEKILLDDNFETRKTPVLPV", "down_seq": "PVLSPSFSAQLYLRPTIQRG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr120", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "120", "end_pos": "120" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LTT6-1.42.42", "start_pos": 42, "end_pos": 42, "uniprot_canonical_ac": "A0A8C2LTT6-1", "length": 877, "uniprot_id": "A0A8C2LTT6_CRIGR", "protein_name": "Serine/threonine-protein kinase", "refseq_ac": "XP_027287138", "refseq_name": "serine/threonine-protein kinase D2 isoform X2", "gene_name": "Prkd2", "gene_names_uniprotkb": "Prkd2", "gene_names_refseq": "Prkd2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LTT6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LTT6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PPAGGSDLQSPPPPLLPQLP", "down_seq": "PASGVSFHIQIGLTREFVLL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr42", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "42", "end_pos": "42" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LUI0-1.1953.1953", "start_pos": 1953, "end_pos": 1953, "uniprot_canonical_ac": "A0A8C2LUI0-1", "length": 2959, "uniprot_id": "A0A8C2LUI0_CRIGR", "protein_name": "Histone-lysine N-methyltransferase ASH1L", "refseq_ac": "XP_027248983", "refseq_name": "histone-lysine N-methyltransferase ASH1L isoform X1", "gene_name": "Ash1l", "gene_names_uniprotkb": "Ash1l", "gene_names_refseq": "Ash1l", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LUI0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LUI0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QQENNKSFTEAPVEIPSPLV", "down_seq": "PSNPSEPESTLQPVMAVIPR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1953", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1953", "end_pos": "1953" }, { "start_pos": "560", "end_pos": "560" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LUI0-1.560.560", "start_pos": 560, "end_pos": 560, "uniprot_canonical_ac": "A0A8C2LUI0-1", "length": 2959, "uniprot_id": "A0A8C2LUI0_CRIGR", "protein_name": "Histone-lysine N-methyltransferase ASH1L", "refseq_ac": "XP_027248983", "refseq_name": "histone-lysine N-methyltransferase ASH1L isoform X1", "gene_name": "Ash1l", "gene_names_uniprotkb": "Ash1l", "gene_names_refseq": "Ash1l", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LUI0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LUI0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "STAKSPFGAVGESNLPSPSP", "down_seq": "VSINPLSRSPPETSSQLAPN", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr560", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1953", "end_pos": "1953" }, { "start_pos": "560", "end_pos": "560" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LUW7-1.1579.1579", "start_pos": 1579, "end_pos": 1579, "uniprot_canonical_ac": "A0A8C2LUW7-1", "length": 1616, "uniprot_id": "A0A8C2LUW7_CRIGR", "protein_name": "Low-density lipoprotein receptor-related protein", "refseq_ac": "XP_027264571", "refseq_name": "low-density lipoprotein receptor-related protein 5 isoform X2", "gene_name": "Lrp5", "gene_names_uniprotkb": "Lrp5", "gene_names_refseq": "Lrp5", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LUW7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LUW7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "KTSKYYLDLNSDSDPYPPPP", "down_seq": "PHSQYLSAEDSCPPSPVTER", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1579", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1579", "end_pos": "1579" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7GQC6-1.763.763", "start_pos": 763, "end_pos": 763, "uniprot_canonical_ac": "A0A9J7GQC6-1", "length": 974, "uniprot_id": "A0A9J7GQC6_CRIGR", "protein_name": "Peptidyl-glycine alpha-amidating monooxygenase isoform X1", "refseq_ac": "XP_007644449", "refseq_name": "peptidyl-glycine alpha-amidating monooxygenase isoform X1", "gene_name": "Pam", "gene_names_uniprotkb": "Pam", "gene_names_refseq": "Pam", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7GQC6", "url": "https://www.uniprot.org/uniprotkb/A0A9J7GQC6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A9J7F834", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F834", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR600720-4", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR600720-4", "database": "PIR Site Rule", "categories": [ "Other" ] }, { "id": "A0A8C2LV12", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LV12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A9J7GVL8", "url": "https://www.uniprot.org/uniprotkb/A0A9J7GVL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A9J7K5Z2", "url": "https://www.uniprot.org/uniprotkb/A0A9J7K5Z2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A9J7FCA2", "url": "https://www.uniprot.org/uniprotkb/A0A9J7FCA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A9J7GQC6", "url": "https://www.uniprot.org/uniprotkb/A0A9J7GQC6", "database": "UniProtKB", "categories": [ "Protein" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "FAVNGKPYFGDHEPVQGFVM", "down_seq": "FSSGEIIDVFKPVRKHFDMP", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn763", "evidence": [ { "id": "A0A9J7F834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F834#ptm_processing" }, { "id": "PIRSR600720-4", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR600720-4" }, { "id": "A0A8C2LV12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LV12#ptm_processing" }, { "id": "A0A9J7GVL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A9J7GVL8#ptm_processing" }, { "id": "A0A9J7K5Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A9J7K5Z2#ptm_processing" }, { "id": "A0A9J7FCA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A9J7FCA2#ptm_processing" }, { "id": "A0A9J7GQC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A9J7GQC6#ptm_processing" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "763", "end_pos": "763" }, { "start_pos": "969", "end_pos": "969" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7GQC6-1.969.969", "start_pos": 969, "end_pos": 969, "uniprot_canonical_ac": "A0A9J7GQC6-1", "length": 974, "uniprot_id": "A0A9J7GQC6_CRIGR", "protein_name": "Peptidyl-glycine alpha-amidating monooxygenase isoform X1", "refseq_ac": "XP_007644449", "refseq_name": "peptidyl-glycine alpha-amidating monooxygenase isoform X1", "gene_name": "Pam", "gene_names_uniprotkb": "Pam", "gene_names_refseq": "Pam", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7GQC6", "url": "https://www.uniprot.org/uniprotkb/A0A9J7GQC6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QEKEEDDGSESEEEYSAPLP", "down_seq": "PAPSS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr969", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "763", "end_pos": "763" }, { "start_pos": "969", "end_pos": "969" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2LX46-1.4189.4189", "start_pos": 4189, "end_pos": 4189, "uniprot_canonical_ac": "A0A8C2LX46-1", "length": 4544, "uniprot_id": "A0A8C2LX46_CRIGR", "protein_name": "Prolow-density lipoprotein receptor-related protein 1", "refseq_ac": "XP_027247995", "refseq_name": "prolow-density lipoprotein receptor-related protein 1 isoform X1", "gene_name": "Lrp1", "gene_names_uniprotkb": "Lrp1", "gene_names_refseq": "Lrp1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2LX46", "url": "https://www.uniprot.org/uniprotkb/A0A8C2LX46" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "CTCPNGKRLDNGTCVPVPSP", "down_seq": "PPPDAPRPGTCTLQCFNGGS", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr4189", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "4189", "end_pos": "4189" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M187-1.25.25", "start_pos": 25, "end_pos": 25, "uniprot_canonical_ac": "A0A8C2M187-1", "length": 400, "uniprot_id": "A0A8C2M187_CRIGR", "protein_name": "Dual specificity mitogen-activated protein kinase kinase 2", "refseq_ac": "XP_007645163", "refseq_name": "dual specificity mitogen-activated protein kinase kinase 2 isoform X1", "gene_name": "Map2k2", "gene_names_uniprotkb": "Map2k2", "gene_names_refseq": "Map2k2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M187", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M187" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RKPVLPALTINPAIAEGPSP", "down_seq": "SEGASEANLVDLQKKLEELD", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr25", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "25", "end_pos": "25" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M4F5-1.2215.2215", "start_pos": 2215, "end_pos": 2215, "uniprot_canonical_ac": "A0A8C2M4F5-1", "length": 2579, "uniprot_id": "A0A8C2M4F5_CRIGR", "protein_name": "Chromodomain-helicase-DNA-binding protein 8", "refseq_ac": "XP_003507745", "refseq_name": "chromodomain-helicase-DNA-binding protein 8 isoform X2", "gene_name": "Chd8", "gene_names_uniprotkb": "Chd8; CHD8", "gene_names_refseq": "Chd8", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M4F5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M4F5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "NHLLDSPSLTPGEYGDSPVP", "down_seq": "PRSSSAASMVEEEASAVTTA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2215", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "2215", "end_pos": "2215" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M4H1-1.2384.2384", "start_pos": 2384, "end_pos": 2384, "uniprot_canonical_ac": "A0A8C2M4H1-1", "length": 2470, "uniprot_id": "A0A8C2M4H1_CRIGR", "protein_name": "Neurogenic locus notch homolog protein 2", "refseq_ac": "XP_027249565", "refseq_name": "neurogenic locus notch homolog protein 2 isoform X2", "gene_name": "Notch2", "gene_names_uniprotkb": "Notch2", "gene_names_refseq": "Notch2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M4H1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M4H1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VAQTIVPTYHPFPASVGKYP", "down_seq": "PPSQHSYASSNAAERTPSHG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2384", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "2384", "end_pos": "2384" }, { "start_pos": "2443", "end_pos": "2443" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M4H1-1.2443.2443", "start_pos": 2443, "end_pos": 2443, "uniprot_canonical_ac": "A0A8C2M4H1-1", "length": 2470, "uniprot_id": "A0A8C2M4H1_CRIGR", "protein_name": "Neurogenic locus notch homolog protein 2", "refseq_ac": "XP_027249565", "refseq_name": "neurogenic locus notch homolog protein 2 isoform X2", "gene_name": "Notch2", "gene_names_uniprotkb": "Notch2", "gene_names_refseq": "Notch2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M4H1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M4H1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QWSSSSPHSASDWSDVTTSP", "down_seq": "PGGVGGGQRGPGTHMSEPPH", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2443", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "2384", "end_pos": "2384" }, { "start_pos": "2443", "end_pos": "2443" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M6S8-1.69.69", "start_pos": 69, "end_pos": 69, "uniprot_canonical_ac": "A0A8C2M6S8-1", "length": 510, "uniprot_id": "A0A8C2M6S8_CRIGR", "protein_name": "Serum response factor", "refseq_ac": "XP_003508375", "refseq_name": "serum response factor isoform X1", "gene_name": "Srf", "gene_names_uniprotkb": "Srf", "gene_names_refseq": "Srf", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M6S8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M6S8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "NGAGLGPGRLEREAAAAAAP", "down_seq": "PAPTAGALYSGSEGDSESGE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr69", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "69", "end_pos": "69" }, { "start_pos": "73", "end_pos": "73" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "upstream", "id": "A0A8C2M6S8-1.73.73", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M6S8-1.73.73", "start_pos": 73, "end_pos": 73, "uniprot_canonical_ac": "A0A8C2M6S8-1", "length": 510, "uniprot_id": "A0A8C2M6S8_CRIGR", "protein_name": "Serum response factor", "refseq_ac": "XP_003508375", "refseq_name": "serum response factor isoform X1", "gene_name": "Srf", "gene_names_uniprotkb": "Srf", "gene_names_refseq": "Srf", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M6S8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M6S8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LGPGRLEREAAAAAAPTPAP", "down_seq": "AGALYSGSEGDSESGEEEEL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr73", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "69", "end_pos": "69" }, { "start_pos": "73", "end_pos": "73" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "downstream", "id": "A0A8C2M6S8-1.69.69", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M705-1.315.315", "start_pos": 315, "end_pos": 315, "uniprot_canonical_ac": "A0A8C2M705-1", "length": 906, "uniprot_id": "A0A8C2M705_CRIGR", "protein_name": "Cadherin-2", "refseq_ac": "XP_027260179", "refseq_name": "cadherin-2 isoform X2", "gene_name": "Cdh2", "gene_names_uniprotkb": "Cdh2", "gene_names_refseq": "Cdh2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M705", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M705" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DDPNALNGMLRYRILSQAPS", "down_seq": "PSPNMFTINNETGDIITVAA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr315", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "315", "end_pos": "315" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M830-1.1851.1851", "start_pos": 1851, "end_pos": 1851, "uniprot_canonical_ac": "A0A8C2M830-1", "length": 2531, "uniprot_id": "A0A8C2M830_CRIGR", "protein_name": "Neurogenic locus notch homolog protein 1", "refseq_ac": "XP_027278772", "refseq_name": "neurogenic locus notch homolog protein 1 isoform X2", "gene_name": "Notch1", "gene_names_uniprotkb": "Notch1", "gene_names_refseq": "Notch1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M830", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M830" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RQWTQQHLDAADLRMSAMAP", "down_seq": "PPQGEVDADCMDVNVRGPDG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1851", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1851", "end_pos": "1851" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2M936-1.602.602", "start_pos": 602, "end_pos": 602, "uniprot_canonical_ac": "A0A8C2M936-1", "length": 1877, "uniprot_id": "A0A8C2M936_CRIGR", "protein_name": "Unconventional myosin-Va", "refseq_ac": "XP_027266949", "refseq_name": "unconventional myosin-Va isoform X2", "gene_name": "Myo5a", "gene_names_uniprotkb": "Myo5a", "gene_names_refseq": "Myo5a", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2M936", "url": "https://www.uniprot.org/uniprotkb/A0A8C2M936" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SSKFKMLPELFQEEEKAISP", "down_seq": "SATSSGRTPLTRVPVKPTKG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr602", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "602", "end_pos": "602" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MBV1-1.212.212", "start_pos": 212, "end_pos": 212, "uniprot_canonical_ac": "A0A8C2MBV1-1", "length": 663, "uniprot_id": "A0A8C2MBV1_CRIGR", "protein_name": "Endoglin", "refseq_ac": "XP_003507215", "refseq_name": "endoglin", "gene_name": "Eng", "gene_names_uniprotkb": "Eng", "gene_names_refseq": "Eng", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MBV1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MBV1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "CLAEAHQDMAPILEWQPQGP", "down_seq": "PVQGCSLEDVTGHKEAYILR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr212", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "212", "end_pos": "212" }, { "start_pos": "553", "end_pos": "553" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MBV1-1.553.553", "start_pos": 553, "end_pos": 553, "uniprot_canonical_ac": "A0A8C2MBV1-1", "length": 663, "uniprot_id": "A0A8C2MBV1_CRIGR", "protein_name": "Endoglin", "refseq_ac": "XP_003507215", "refseq_name": "endoglin", "gene_name": "Eng", "gene_names_uniprotkb": "Eng", "gene_names_refseq": "Eng", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MBV1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MBV1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SPEGDPRFSFLLHVYMMPTP", "down_seq": "AGTLSCNVALQPSTVSQEVY", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr553", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "212", "end_pos": "212" }, { "start_pos": "553", "end_pos": "553" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MCQ3-1.71.71", "start_pos": 71, "end_pos": 71, "uniprot_canonical_ac": "A0A8C2MCQ3-1", "length": 321, "uniprot_id": "A0A8C2MCQ3_CRIGR", "protein_name": "Solute carrier family 25 member 33", "refseq_ac": "XP_027254083", "refseq_name": "solute carrier family 25 member 33 isoform X2", "gene_name": "Slc25a33", "gene_names_uniprotkb": "Slc25a33", "gene_names_refseq": "Slc25a33", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MCQ3", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MCQ3" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "YPQVHLGTISGAGMMRPTSV", "down_seq": "PGLLQVLKSILEKEGPKSLF", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr71", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "71", "end_pos": "71" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MDK8-1.418.418", "start_pos": 418, "end_pos": 418, "uniprot_canonical_ac": "A0A8C2MDK8-1", "length": 438, "uniprot_id": "DPH1_CRIGR", "protein_name": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1", "refseq_ac": "", "refseq_name": "", "gene_name": "DPH1", "gene_names_uniprotkb": "DPH1; OVCA1", "gene_names_refseq": "", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MDK8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MDK8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A8C2MDK8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MDK8", "database": "UniProtKB", "categories": [ "Protein" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "GPRGLGQPASGKVQQGFRGQ", "down_seq": "PAPACEGCSCADLKAALPAS", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MDK8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MDK8" } ], "site_lbl": "Ser418" } ], "all_sites": [ { "type": "phosphorylation", "site_list": [ { "start_pos": "418", "end_pos": "418" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MH74-1.310.310", "start_pos": 310, "end_pos": 310, "uniprot_canonical_ac": "A0A8C2MH74-1", "length": 1161, "uniprot_id": "A0A8C2MH74_CRIGR", "protein_name": "Hamartin isoform X1", "refseq_ac": "XP_003513313", "refseq_name": "hamartin isoform X1", "gene_name": "Tsc1", "gene_names_uniprotkb": "Tsc1", "gene_names_refseq": "Tsc1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MH74", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MH74" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ADVTASPYVDTQNSYGGTTS", "down_seq": "PSSTSRLMLFSPAGQLPQSL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr310", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "310", "end_pos": "310" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MHG1-1.379.379", "start_pos": 379, "end_pos": 379, "uniprot_canonical_ac": "A0A8C2MHG1-1", "length": 463, "uniprot_id": "A0A8C2MHG1_CRIGR", "protein_name": "Hyaluronidase", "refseq_ac": "XP_003500449", "refseq_name": "hyaluronidase-1", "gene_name": "Hyal1", "gene_names_uniprotkb": "Hyal1", "gene_names_refseq": "Hyal1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MHG1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MHG1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A8C2MHG1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MHG1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR038193-2", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038193-2", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "KESCQTIKEYMDSTLGPFIL", "down_seq": "VTSAALLCSEALCSGHGRCA", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn379", "evidence": [ { "id": "A0A8C2MHG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MHG1#ptm_processing" }, { "id": "PIRSR038193-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038193-2" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "379", "end_pos": "379" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MJW7-1.431.431", "start_pos": 431, "end_pos": 431, "uniprot_canonical_ac": "A0A8C2MJW7-1", "length": 508, "uniprot_id": "A0A8C2MJW7_CRIGR", "protein_name": "E3 SUMO-protein ligase PIAS4", "refseq_ac": "XP_016833067", "refseq_name": "E3 SUMO-protein ligase PIAS4 isoform X1", "gene_name": "Pias4", "gene_names_uniprotkb": "Pias4", "gene_names_refseq": "Pias4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MJW7", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MJW7" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QGPILVLGTSDANGLPPASS", "down_seq": "PGVGGSVGSSLGGAGSGAGA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr431", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "431", "end_pos": "431" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MNP8-1.126.126", "start_pos": 126, "end_pos": 126, "uniprot_canonical_ac": "A0A8C2MNP8-1", "length": 166, "uniprot_id": "A0A8C2MNP8_CRIGR", "protein_name": "Transcription factor HES-5", "refseq_ac": "XP_027254259", "refseq_name": "transcription factor HES-5", "gene_name": "LOC113833739", "gene_names_uniprotkb": "LOC113833739", "gene_names_refseq": "LOC113833739", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MNP8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MNP8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "HAASDTQMKLLYHFQRPPAP", "down_seq": "APTKEPPAPGAAPHPVRSPA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr126", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "126", "end_pos": "126" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MQ81-1.1075.1075", "start_pos": 1075, "end_pos": 1075, "uniprot_canonical_ac": "A0A8C2MQ81-1", "length": 1251, "uniprot_id": "A0A8C2MQ81_CRIGR", "protein_name": "Phospholipid-transporting ATPase", "refseq_ac": "XP_035296011", "refseq_name": "phospholipid-transporting ATPase IC", "gene_name": "Atp8b1", "gene_names_uniprotkb": "Atp8b1", "gene_names_refseq": "Atp8b1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MQ81", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MQ81" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "YLQTVGQDGEAPSDYQSFAV", "down_seq": "VASALVITVNFQIGLDTSYW", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1075", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1075", "end_pos": "1075" }, { "start_pos": "380", "end_pos": "380" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MQ81-1.380.380", "start_pos": 380, "end_pos": 380, "uniprot_canonical_ac": "A0A8C2MQ81-1", "length": 1251, "uniprot_id": "A0A8C2MQ81_CRIGR", "protein_name": "Phospholipid-transporting ATPase", "refseq_ac": "XP_035296011", "refseq_name": "phospholipid-transporting ATPase IC", "gene_name": "Atp8b1", "gene_names_uniprotkb": "Atp8b1", "gene_names_refseq": "Atp8b1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MQ81", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MQ81" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AYWEAQVGNYSWYLYDGENA", "down_seq": "PSYRGFLNFWGYIIVLNTMV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr380", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1075", "end_pos": "1075" }, { "start_pos": "380", "end_pos": "380" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MSI1-1.690.690", "start_pos": 690, "end_pos": 690, "uniprot_canonical_ac": "A0A8C2MSI1-1", "length": 843, "uniprot_id": "A0A8C2MSI1_CRIGR", "protein_name": "ATP-binding cassette sub-family B member 6", "refseq_ac": "XP_003507643", "refseq_name": "LOW QUALITY PROTEIN: ATP-binding cassette sub-family B member 6, mitochondrial", "gene_name": "Abcb6", "gene_names_uniprotkb": "Abcb6", "gene_names_refseq": "Abcb6", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MSI1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MSI1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PQDTVLFNDTIANNIRYGRV", "down_seq": "AGDSEVEAAAQAAGIHDAIL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr690", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "690", "end_pos": "690" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QMK6-1.416.416", "start_pos": 416, "end_pos": 416, "uniprot_canonical_ac": "A0A8C2QMK6-1", "length": 864, "uniprot_id": "A0A8C2QMK6_CRIGR", "protein_name": "Tyrosine-protein kinase receptor", "refseq_ac": "XP_035297265", "refseq_name": "NT-3 growth factor receptor isoform X3", "gene_name": "Ntrk3", "gene_names_uniprotkb": "Ntrk3", "gene_names_refseq": "Ntrk3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QMK6", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QMK6" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LKEPFPESTDFFDFESDTSP", "down_seq": "PPITVTHKPEEDTFGVSIAV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr416", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "416", "end_pos": "416" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N1E9-1.10.10", "start_pos": 10, "end_pos": 10, "uniprot_canonical_ac": "A0A8C2N1E9-1", "length": 463, "uniprot_id": "A0A8C2N1E9_CRIGR", "protein_name": "Retinoic acid receptor alpha isoform X1", "refseq_ac": "XP_003510530", "refseq_name": "retinoic acid receptor alpha isoform X1", "gene_name": "Rara", "gene_names_uniprotkb": "Rara", "gene_names_refseq": "Rara", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N1E9", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N1E9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "MASNSSSCP", "down_seq": "PGGGHLNGYPVPPYAFFFPP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr10", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "10", "end_pos": "10" }, { "start_pos": "55", "end_pos": "55" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N1E9-1.55.55", "start_pos": 55, "end_pos": 55, "uniprot_canonical_ac": "A0A8C2N1E9-1", "length": 463, "uniprot_id": "A0A8C2N1E9_CRIGR", "protein_name": "Retinoic acid receptor alpha isoform X1", "refseq_ac": "XP_003510530", "refseq_name": "retinoic acid receptor alpha isoform X1", "gene_name": "Rara", "gene_names_uniprotkb": "Rara", "gene_names_refseq": "Rara", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N1E9", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N1E9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LSPPGALASLQHQLPVSGYS", "down_seq": "PSPATIETQSSSSEEIVPSP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr55", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "10", "end_pos": "10" }, { "start_pos": "55", "end_pos": "55" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MX24-1.101.101", "start_pos": 101, "end_pos": 101, "uniprot_canonical_ac": "A0A8C2MX24-1", "length": 430, "uniprot_id": "A0A8C2MX24_CRIGR", "protein_name": "Pre-B-cell leukemia transcription factor 1", "refseq_ac": "XP_016831969", "refseq_name": "pre-B-cell leukemia transcription factor 1 isoform X1", "gene_name": "Pbx1", "gene_names_uniprotkb": "Pbx1", "gene_names_refseq": "Pbx1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MX24", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MX24" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LCEIKEKTVLSIRGAQEEEP", "down_seq": "DPQLMRLDNMLLAEGVAGPE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr101", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "101", "end_pos": "101" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MX39-1.64.64", "start_pos": 64, "end_pos": 64, "uniprot_canonical_ac": "A0A8C2MX39-1", "length": 261, "uniprot_id": "A0A8C2MX39_CRIGR", "protein_name": "Galectin", "refseq_ac": "XP_003500109", "refseq_name": "galectin-3", "gene_name": "Lgals3", "gene_names_uniprotkb": "Lgals3", "gene_names_refseq": "Lgals3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MX39", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MX39" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GQAPPGAYPGQAPPSAYPGP", "down_seq": "APGAYPGSTAPGAYPGPTAP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr64", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "64", "end_pos": "64" }, { "start_pos": "82", "end_pos": "82" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 18, "direction": "upstream", "id": "A0A8C2MX39-1.82.82", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MX39-1.82.82", "start_pos": 82, "end_pos": 82, "uniprot_canonical_ac": "A0A8C2MX39-1", "length": 261, "uniprot_id": "A0A8C2MX39_CRIGR", "protein_name": "Galectin", "refseq_ac": "XP_003500109", "refseq_name": "galectin-3", "gene_name": "Lgals3", "gene_names_uniprotkb": "Lgals3", "gene_names_refseq": "Lgals3", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MX39", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MX39" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GPTAPGAYPGSTAPGAYPGP", "down_seq": "APGAYPGSAPGAFPGQPGAP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr82", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "64", "end_pos": "64" }, { "start_pos": "82", "end_pos": "82" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 18, "direction": "downstream", "id": "A0A8C2MX39-1.64.64", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MXJ8-1.175.175", "start_pos": 175, "end_pos": 175, "uniprot_canonical_ac": "A0A8C2MXJ8-1", "length": 388, "uniprot_id": "A0A8C2MXJ8_CRIGR", "protein_name": "P2X purinoceptor", "refseq_ac": "XP_027269838", "refseq_name": "P2X purinoceptor 7 isoform X2", "gene_name": "LOC100752103", "gene_names_uniprotkb": "LOC100752103", "gene_names_refseq": "LOC100752103", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MXJ8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MXJ8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SVKTCEVAAWCPVENDADVP", "down_seq": "PAFLKAAENFTLLVKNNIWY", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr175", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "175", "end_pos": "175" }, { "start_pos": "184", "end_pos": "184" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 9, "direction": "upstream", "id": "A0A8C2MXJ8-1.184.184", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2MXJ8-1.184.184", "start_pos": 184, "end_pos": 184, "uniprot_canonical_ac": "A0A8C2MXJ8-1", "length": 388, "uniprot_id": "A0A8C2MXJ8_CRIGR", "protein_name": "P2X purinoceptor", "refseq_ac": "XP_027269838", "refseq_name": "P2X purinoceptor 7 isoform X2", "gene_name": "LOC100752103", "gene_names_uniprotkb": "LOC100752103", "gene_names_refseq": "LOC100752103", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2MXJ8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MXJ8" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A8C2MXJ8", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MXJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR005713-3", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005713-3", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "WCPVENDADVPTPAFLKAAE", "down_seq": "FTLLVKNNIWYPKFNFSKRN", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn184", "evidence": [ { "id": "A0A8C2MXJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8C2MXJ8#ptm_processing" }, { "id": "PIRSR005713-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005713-3" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "175", "end_pos": "175" }, { "start_pos": "184", "end_pos": "184" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 9, "direction": "downstream", "id": "A0A8C2MXJ8-1.175.175", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N043-1.398.398", "start_pos": 398, "end_pos": 398, "uniprot_canonical_ac": "A0A8C2N043-1", "length": 521, "uniprot_id": "A0A8C2N043_CRIGR", "protein_name": "4-trimethylaminobutyraldehyde dehydrogenase", "refseq_ac": "XP_027272903", "refseq_name": "4-trimethylaminobutyraldehyde dehydrogenase", "gene_name": "Aldh9a1", "gene_names_uniprotkb": "Aldh9a1", "gene_names_refseq": "Aldh9a1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N043", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N043" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LYGGDQYVPKDPKLKFGYYM", "down_seq": "PCILTNCRDNMTCVKEEIFG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr398", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "398", "end_pos": "398" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N168-1.357.357", "start_pos": 357, "end_pos": 357, "uniprot_canonical_ac": "A0A8C2N168-1", "length": 473, "uniprot_id": "A0A8C2N168_CRIGR", "protein_name": "Hyaluronidase", "refseq_ac": "XP_027270267", "refseq_name": "hyaluronidase-2", "gene_name": "Hyal2", "gene_names_uniprotkb": "Hyal2", "gene_names_refseq": "Hyal2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N168", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N168" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A8C2N168", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N168", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "PIRSR038193-2", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038193-2", "database": "PIR Site Rule", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "METCQYLKNYLTQWLVPYVV", "down_seq": "VSWATQYCSWTQCNGHGRCV", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn357", "evidence": [ { "id": "A0A8C2N168", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N168#ptm_processing" }, { "id": "PIRSR038193-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038193-2" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "357", "end_pos": "357" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N1D1-1.1851.1851", "start_pos": 1851, "end_pos": 1851, "uniprot_canonical_ac": "A0A8C2N1D1-1", "length": 2480, "uniprot_id": "A0A8C2N1D1_CRIGR", "protein_name": "Fibronectin", "refseq_ac": "XP_027252957", "refseq_name": "fibronectin isoform X1", "gene_name": "Fn1", "gene_names_uniprotkb": "Fn1", "gene_names_refseq": "Fn1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N1D1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N1D1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SFSAQWVAPNVQLTGYRVRV", "down_seq": "PKEKTGPMKEINLSPDSSSV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1851", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "821", "end_pos": "821" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N1D1-1.821.821", "start_pos": 821, "end_pos": 821, "uniprot_canonical_ac": "A0A8C2N1D1-1", "length": 2480, "uniprot_id": "A0A8C2N1D1_CRIGR", "protein_name": "Fibronectin", "refseq_ac": "XP_027252957", "refseq_name": "fibronectin isoform X1", "gene_name": "Fn1", "gene_names_uniprotkb": "Fn1", "gene_names_refseq": "Fn1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N1D1", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N1D1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "KQSLILSTSQTTAPDAPPDP", "down_seq": "VDQVDDTSIVVRWSRPQAPI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr821", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "821", "end_pos": "821" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N2P0-1.28.28", "start_pos": 28, "end_pos": 28, "uniprot_canonical_ac": "A0A8C2N2P0-1", "length": 498, "uniprot_id": "A0A8C2N2P0_CRIGR", "protein_name": "O-acyltransferase", "refseq_ac": "XP_027260055", "refseq_name": "diacylglycerol O-acyltransferase 1 isoform X2", "gene_name": "Dgat1", "gene_names_uniprotkb": "Dgat1", "gene_names_refseq": "Dgat1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N2P0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N2P0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GGSRRRRTGSRVPVQGGGGP", "down_seq": "AAEEEVRDAAVGPDLGAGGD", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr28", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "28", "end_pos": "28" }, { "start_pos": "59", "end_pos": "59" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N2P0-1.59.59", "start_pos": 59, "end_pos": 59, "uniprot_canonical_ac": "A0A8C2N2P0-1", "length": 498, "uniprot_id": "A0A8C2N2P0_CRIGR", "protein_name": "O-acyltransferase", "refseq_ac": "XP_027260055", "refseq_name": "diacylglycerol O-acyltransferase 1 isoform X2", "gene_name": "Dgat1", "gene_names_uniprotkb": "Dgat1", "gene_names_refseq": "Dgat1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N2P0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N2P0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VGPDLGAGGDAPAPAPAPVP", "down_seq": "PDKDRHTNVGDGHWELRCHR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr59", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "28", "end_pos": "28" }, { "start_pos": "59", "end_pos": "59" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N3D5-1.179.179", "start_pos": 179, "end_pos": 179, "uniprot_canonical_ac": "A0A8C2N3D5-1", "length": 483, "uniprot_id": "A0A8C2N3D5_CRIGR", "protein_name": "Krueppel-like factor 4 isoform X1", "refseq_ac": "XP_003511964", "refseq_name": "Krueppel-like factor 4 isoform X1", "gene_name": "Klf4", "gene_names_uniprotkb": "Klf4", "gene_names_refseq": "Klf4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N3D5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N3D5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VAAGNTGGGLLYPRESAPPP", "down_seq": "APFNLADINDVSPSGGFVAE", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr179", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "179", "end_pos": "179" }, { "start_pos": "234", "end_pos": "234" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N3D5-1.234.234", "start_pos": 234, "end_pos": 234, "uniprot_canonical_ac": "A0A8C2N3D5-1", "length": 483, "uniprot_id": "A0A8C2N3D5_CRIGR", "protein_name": "Krueppel-like factor 4 isoform X1", "refseq_ac": "XP_003511964", "refseq_name": "Krueppel-like factor 4 isoform X1", "gene_name": "Klf4", "gene_names_uniprotkb": "Klf4", "gene_names_refseq": "Klf4", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N3D5", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N3D5" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QPQPPGGGLMGKFVLKASLS", "down_seq": "PGSEYSSPSVISVSKGSPDG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr234", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "179", "end_pos": "179" }, { "start_pos": "234", "end_pos": "234" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N589-1.370.370", "start_pos": 370, "end_pos": 370, "uniprot_canonical_ac": "A0A8C2N589-1", "length": 1218, "uniprot_id": "A0A8C2N589_CRIGR", "protein_name": "Delta-like protein", "refseq_ac": "XP_027277473", "refseq_name": "protein jagged-1 isoform X3", "gene_name": "Jag1", "gene_names_uniprotkb": "Jag1", "gene_names_refseq": "Jag1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N589", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N589" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SCKETSLGFECECSPGWTGP", "down_seq": "CSTNIDDCSPNNCSHGGTCQ", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr370", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "370", "end_pos": "370" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N659-1.632.632", "start_pos": 632, "end_pos": 632, "uniprot_canonical_ac": "A0A8C2N659-1", "length": 1141, "uniprot_id": "A0A8C2N659_CRIGR", "protein_name": "Tyrosine-protein kinase", "refseq_ac": "XP_027279670", "refseq_name": "tyrosine-protein kinase ABL1 isoform X2", "gene_name": "Abl1", "gene_names_uniprotkb": "Abl1", "gene_names_refseq": "Abl1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N659", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N659" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "KDKKTNLFSALIKKKKKMAP", "down_seq": "PPKRSSSFREMDGQPERRGP", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr632", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "632", "end_pos": "632" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "999", "end_pos": "999" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N659-1.869.869", "start_pos": 869, "end_pos": 869, "uniprot_canonical_ac": "A0A8C2N659-1", "length": 1141, "uniprot_id": "A0A8C2N659_CRIGR", "protein_name": "Tyrosine-protein kinase", "refseq_ac": "XP_027279670", "refseq_name": "tyrosine-protein kinase ABL1 isoform X2", "gene_name": "Abl1", "gene_names_uniprotkb": "Abl1", "gene_names_refseq": "Abl1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N659", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N659" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SHKEETTKGNALGTPATAEP", "down_seq": "PPSSRVGLNKASSEESRVRR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr869", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "632", "end_pos": "632" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "999", "end_pos": "999" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N659-1.999.999", "start_pos": 999, "end_pos": 999, "uniprot_canonical_ac": "A0A8C2N659-1", "length": 1141, "uniprot_id": "A0A8C2N659_CRIGR", "protein_name": "Tyrosine-protein kinase", "refseq_ac": "XP_027279670", "refseq_name": "tyrosine-protein kinase ABL1 isoform X2", "gene_name": "Abl1", "gene_names_uniprotkb": "Abl1", "gene_names_refseq": "Abl1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N659", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N659" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "STSKPPGTPTSPVSTAPTAP", "down_seq": "PSSLPGDQPSSAAFIPLIST", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr999", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "632", "end_pos": "632" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "999", "end_pos": "999" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2N999-1.42.42", "start_pos": 42, "end_pos": 42, "uniprot_canonical_ac": "A0A8C2N999-1", "length": 488, "uniprot_id": "A0A8C2N999_CRIGR", "protein_name": "Multifunctional fusion protein", "refseq_ac": "XP_003496697", "refseq_name": "katanin p60 ATPase-containing subunit A-like 1", "gene_name": "Katnal1", "gene_names_uniprotkb": "Katnal1; KATNA1; KATNAL1", "gene_names_refseq": "Katnal1", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N999", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N999" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "A0A8C2N999", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N999", "database": "UniProtKB", "categories": [ "Protein" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "YDSSMVYYQGVIQQIQRHCQ", "down_seq": "VRDPAVKGKWHQVRQELLEE", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by DYRK2", "evidence": [ { "database": "UniProtKB", "id": "A0A8C2N999", "url": "https://www.uniprot.org/uniprotkb/A0A8C2N999" } ], "site_lbl": "Ser42" } ], "all_sites": [ { "type": "phosphorylation", "site_list": [ { "start_pos": "42", "end_pos": "42" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QCN9-1.208.208", "start_pos": 208, "end_pos": 208, "uniprot_canonical_ac": "A0A8C2QCN9-1", "length": 394, "uniprot_id": "A0A8C2QCN9_CRIGR", "protein_name": "Bone morphogenetic protein 2", "refseq_ac": "XP_027277498", "refseq_name": "bone morphogenetic protein 2 isoform X2", "gene_name": "Bmp2", "gene_names_uniprotkb": "Bmp2", "gene_names_refseq": "Bmp2", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QCN9", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QCN9" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RLLDTRLVNQNTSQWESFDV", "down_seq": "PAVMRWTAQGHTNHGFVVEV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr208", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "208", "end_pos": "208" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A9J7F8Q1-1.190.190", "start_pos": 190, "end_pos": 190, "uniprot_canonical_ac": "A0A9J7F8Q1-1", "length": 384, "uniprot_id": "A0A9J7F8Q1_CRIGR", "protein_name": "All-trans-retinol dehydrogenase [NAD(+)] ADH7", "refseq_ac": "XP_007605770", "refseq_name": "all-trans-retinol dehydrogenase [NAD(+)] ADH7 isoform X1", "gene_name": "Adh7", "gene_names_uniprotkb": "Adh7", "gene_names_refseq": "Adh7", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A9J7F8Q1", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F8Q1" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "CLIGCGFSTGYGAAVKTAKV", "down_seq": "PGSTCVVFGLGGVGLSVIMG", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr190", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "190", "end_pos": "190" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QFY0-1.246.246", "start_pos": 246, "end_pos": 246, "uniprot_canonical_ac": "A0A8C2QFY0-1", "length": 494, "uniprot_id": "A0A8C2QFY0_CRIGR", "protein_name": "Forkhead box protein C2", "refseq_ac": "XP_027266608", "refseq_name": "forkhead box protein C2", "gene_name": "LOC113835145", "gene_names_uniprotkb": "LOC113835145", "gene_names_refseq": "LOC113835145", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QFY0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QFY0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "KVETLSPEGALQASPRSAAS", "down_seq": "PAGSPDGSLPEHHAAAPNGL", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr246", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "246", "end_pos": "246" }, { "start_pos": "477", "end_pos": "477" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "A0A8C2QFY0-1.477.477", "start_pos": 477, "end_pos": 477, "uniprot_canonical_ac": "A0A8C2QFY0-1", "length": 494, "uniprot_id": "A0A8C2QFY0_CRIGR", "protein_name": "Forkhead box protein C2", "refseq_ac": "XP_027266608", "refseq_name": "forkhead box protein C2", "gene_name": "LOC113835145", "gene_names_uniprotkb": "LOC113835145", "gene_names_refseq": "LOC113835145", "species": [ { "name": "Cricetulus griseus", "taxid": 10029, "evidence": [ { "database": "UniProtKB", "id": "A0A8C2QFY0", "url": "https://www.uniprot.org/uniprotkb/A0A8C2QFY0" } ], "common_name": "Chinese hamster", "glygen_name": "Hamster", "reference_species": "Cricetulus griseus [10029]" } ], "publication": [], "crossref": [ { "id": "", "url": "https://data.glygen.org/", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "NSTLGESQVSNASCQLPYRA", "down_seq": "PSLYRHAAPYSYDCTKY", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr477", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "246", "end_pos": "246" }, { "start_pos": "477", "end_pos": "477" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8TES7-1.373.373", "start_pos": 373, "end_pos": 373, "uniprot_canonical_ac": "Q8TES7-1", "length": 1133, "uniprot_id": "FBF1_HUMAN", "protein_name": "Fas-binding factor 1", "refseq_ac": "NP_001306122", "refseq_name": "fas-binding factor 1", "gene_name": "FBF1", "gene_names_uniprotkb": "FBF1; ALB; KIAA1863", "gene_names_refseq": "Alb; FBF-1; FBF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8TES7", "url": "https://www.uniprot.org/uniprotkb/Q8TES7" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "GLY_001151", "url": "https://data.glygen.org/GLY_001151", "database": "GlyGen", "categories": [ "Other" ] }, { "id": "rs76114706", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs76114706", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs76114706", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs76114706", "database": "1000Genomes", "categories": [ "Other" ] }, { "id": "rs76114706", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs76114706", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs76114706", "url": "https://www.ncbi.nlm.nih.gov/snp/rs76114706#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs76114706", "url": "http://gnomad.broadinstitute.org/awesome?query=rs76114706", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "rs1598156765", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1598156765", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1598156765", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1598156765#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LDLFPASPTREAHRESSVPV", "down_seq": "PSVPPPASQHSTPAGLPPSR", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr373", "evidence": [ { "id": "GLY_001151", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001151" } ] } ], "snv": [ { "evidence": [ { "id": "rs76114706", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs76114706" }, { "id": "rs76114706", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs76114706" }, { "id": "rs76114706", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs76114706" }, { "id": "rs76114706", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs76114706#frequency_tab" }, { "id": "rs76114706", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs76114706" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "T", "sequence_mut": "M", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (T->M).", "chr_id": "17", "chr_pos": "75923450", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "0.000784929", "site_lbl": "T373", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1598156765", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1598156765" }, { "id": "rs1598156765", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1598156765#frequency_tab" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "T", "sequence_mut": "P", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (T->P).", "chr_id": "17", "chr_pos": "75923451", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T373", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "373", "end_pos": "373" } ] }, { "type": "snv", "site_list": [ { "start_pos": "115", "end_pos": "115" }, { "start_pos": "1044", "end_pos": "1044" }, { "start_pos": "125", "end_pos": "125" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "373", "end_pos": "373" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "520", "end_pos": "520" }, { "start_pos": "746", "end_pos": "746" }, { "start_pos": "979", "end_pos": "979" }, { "start_pos": "97", "end_pos": "97" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "142", "end_pos": "142" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8TES7-1.115.115", "start_pos": 115, "end_pos": 115, "uniprot_canonical_ac": "Q8TES7-1", "length": 1133, "uniprot_id": "FBF1_HUMAN", "protein_name": "Fas-binding factor 1", "refseq_ac": "NP_001306122", "refseq_name": "fas-binding factor 1", "gene_name": "FBF1", "gene_names_uniprotkb": "FBF1; ALB; KIAA1863", "gene_names_refseq": "Alb; FBF-1; FBF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8TES7", "url": "https://www.uniprot.org/uniprotkb/Q8TES7" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q8TES7", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8TES7", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs2065573217", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2065573217", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs2065573217", "url": "http://gnomad.broadinstitute.org/awesome?query=rs2065573217", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "rs2065573217", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs2065573217", "database": "COSMIC", "categories": [ "Other" ] } ], "site_seq": "P", "start_aa": "P", "up_seq": "NSAPSKKAAKDPGKGELPNH", "down_seq": "KPAGGAIPTKKSLPSPSSSG", "snv": [ { "evidence": [ { "id": "Q8TES7", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8TES7" }, { "id": "rs2065573217", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2065573217" }, { "id": "rs2065573217", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs2065573217" }, { "id": "rs2065573217", "database": "COSMIC", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs2065573217" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "subjects_tested": "1773", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "P", "sequence_mut": "S", "comment": "Somatic mutation passed 2 filters: num. of cancers (3); n-glyco-sequon-gain (NHP->NHS).", "chr_id": "17", "chr_pos": "75928088", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "P115", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "373", "end_pos": "373" } ] }, { "type": "snv", "site_list": [ { "start_pos": "115", "end_pos": "115" }, { "start_pos": "1044", "end_pos": "1044" }, { "start_pos": "125", "end_pos": "125" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "373", "end_pos": "373" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "520", "end_pos": "520" }, { "start_pos": "746", "end_pos": "746" }, { "start_pos": "979", "end_pos": "979" }, { "start_pos": "97", "end_pos": "97" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "142", "end_pos": "142" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 18, "direction": "downstream", "id": "Q8TES7-1.97.97", "categories": [ "snv_flag" ] }, { "distance": 10, "direction": "upstream", "id": "Q8TES7-1.125.125", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8TES7-1.1044.1044", "start_pos": 1044, "end_pos": 1044, "uniprot_canonical_ac": "Q8TES7-1", "length": 1133, "uniprot_id": "FBF1_HUMAN", "protein_name": "Fas-binding factor 1", "refseq_ac": "NP_001306122", "refseq_name": "fas-binding factor 1", "gene_name": "FBF1", "gene_names_uniprotkb": "FBF1; ALB; KIAA1863", "gene_names_refseq": "Alb; FBF-1; FBF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8TES7", "url": "https://www.uniprot.org/uniprotkb/Q8TES7" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q8TES7", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8TES7", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "QHMHQEHLSLAQQRLQLDRA", "down_seq": "QDLPSSLVGLFPRAQGPAAS", "snv": [ { "evidence": [ { "id": "Q8TES7", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8TES7" } ], "glycoeffect": [], "subjects_tested": "720", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "R", "sequence_mut": "*", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "17", "chr_pos": "75913774", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "R1044", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ], "unlinked_id_list": [ "DOID:1542" ], "evidence": [ { "id": "11934", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11934" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "373", "end_pos": "373" } ] }, { "type": "snv", "site_list": [ { "start_pos": "115", "end_pos": "115" }, { "start_pos": "1044", "end_pos": "1044" }, { "start_pos": "125", "end_pos": "125" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "373", "end_pos": "373" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "520", "end_pos": "520" }, { "start_pos": "746", "end_pos": "746" }, { "start_pos": "979", "end_pos": "979" }, { "start_pos": "97", "end_pos": "97" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "142", "end_pos": "142" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8TES7-1.125.125", "start_pos": 125, "end_pos": 125, "uniprot_canonical_ac": "Q8TES7-1", "length": 1133, "uniprot_id": "FBF1_HUMAN", "protein_name": "Fas-binding factor 1", "refseq_ac": "NP_001306122", "refseq_name": "fas-binding factor 1", "gene_name": "FBF1", "gene_names_uniprotkb": "FBF1; ALB; KIAA1863", "gene_names_refseq": "Alb; FBF-1; FBF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8TES7", "url": "https://www.uniprot.org/uniprotkb/Q8TES7" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1247701860", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1247701860", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1247701860", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1247701860", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "DPGKGELPNHPKPAGGAIPT", "down_seq": "KSLPSPSSSGHQNRRFSSED", "snv": [ { "evidence": [ { "id": "rs1247701860", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1247701860" }, { "id": "rs1247701860", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1247701860" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (KKS->NKS).", "chr_id": "17", "chr_pos": "75927513", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K125", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "373", "end_pos": "373" } ] }, { "type": "snv", "site_list": [ { "start_pos": "115", "end_pos": "115" }, { "start_pos": "1044", "end_pos": "1044" }, { "start_pos": "125", "end_pos": "125" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "373", "end_pos": "373" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "520", "end_pos": "520" }, { "start_pos": "746", "end_pos": "746" }, { "start_pos": "979", "end_pos": "979" }, { "start_pos": "97", "end_pos": "97" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "142", "end_pos": "142" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 10, "direction": "downstream", "id": "Q8TES7-1.115.115", "categories": [ "snv_flag" ] }, { "distance": 15, "direction": "upstream", "id": "Q8TES7-1.140.140", "categories": [ "snv_flag" ] }, { "distance": 17, "direction": "upstream", "id": "Q8TES7-1.142.142", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8TES7-1.140.140", "start_pos": 140, "end_pos": 140, "uniprot_canonical_ac": "Q8TES7-1", "length": 1133, "uniprot_id": "FBF1_HUMAN", "protein_name": "Fas-binding factor 1", "refseq_ac": "NP_001306122", "refseq_name": "fas-binding factor 1", "gene_name": "FBF1", "gene_names_uniprotkb": "FBF1; ALB; KIAA1863", "gene_names_refseq": "Alb; FBF-1; FBF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8TES7", "url": "https://www.uniprot.org/uniprotkb/Q8TES7" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs778301808", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778301808", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs778301808", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778301808", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs778301808", "url": "http://gnomad.broadinstitute.org/awesome?query=rs778301808", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "rs2065569414", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2065569414", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs2065569414", "url": "http://gnomad.broadinstitute.org/awesome?query=rs2065569414", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "GAIPTKKSLPSPSSSGHQNR", "down_seq": "FSSEDLEDPLRGLLSYDEGG", "snv": [ { "evidence": [ { "id": "rs778301808", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778301808" }, { "id": "rs778301808", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778301808" }, { "id": "rs778301808", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs778301808" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "R", "sequence_mut": "S", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (NRR->NRS).", "chr_id": "17", "chr_pos": "75927468", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "R140", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs2065569414", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2065569414" }, { "id": "rs2065569414", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs2065569414" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "R", "sequence_mut": "T", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (NRR->NRT).", "chr_id": "17", "chr_pos": "75927469", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "R140", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "373", "end_pos": "373" } ] }, { "type": "snv", "site_list": [ { "start_pos": "115", "end_pos": "115" }, { "start_pos": "1044", "end_pos": "1044" }, { "start_pos": "125", "end_pos": "125" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "373", "end_pos": "373" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "520", "end_pos": "520" }, { "start_pos": "746", "end_pos": "746" }, { "start_pos": "979", "end_pos": "979" }, { "start_pos": "97", "end_pos": "97" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "142", "end_pos": "142" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 15, "direction": "downstream", "id": "Q8TES7-1.125.125", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q8TES7-1.142.142", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8TES7-1.235.235", "start_pos": 235, "end_pos": 235, "uniprot_canonical_ac": "Q8TES7-1", "length": 1133, "uniprot_id": "FBF1_HUMAN", "protein_name": "Fas-binding factor 1", "refseq_ac": "NP_001306122", "refseq_name": "fas-binding factor 1", "gene_name": "FBF1", "gene_names_uniprotkb": "FBF1; ALB; KIAA1863", "gene_names_refseq": "Alb; FBF-1; FBF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8TES7", "url": "https://www.uniprot.org/uniprotkb/Q8TES7" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q8TES7", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8TES7", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "LGFGDSPKAEKRQIGDQEGP", "down_seq": "PARSTLDELLGRGMATKLLA", "snv": [ { "evidence": [ { "id": "Q8TES7", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8TES7" } ], "glycoeffect": [], "subjects_tested": "4484", "subjects_positive": "2", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "C", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "17", "chr_pos": "75926153", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "R235", "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "373", "end_pos": "373" } ] }, { "type": "snv", "site_list": [ { "start_pos": "115", "end_pos": "115" }, { "start_pos": "1044", "end_pos": "1044" }, { "start_pos": "125", "end_pos": "125" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "373", "end_pos": "373" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "520", "end_pos": "520" }, { "start_pos": "746", "end_pos": "746" }, { "start_pos": "979", "end_pos": "979" }, { "start_pos": "97", "end_pos": "97" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "142", "end_pos": "142" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8TES7-1.465.465", "start_pos": 465, "end_pos": 465, "uniprot_canonical_ac": "Q8TES7-1", "length": 1133, "uniprot_id": "FBF1_HUMAN", "protein_name": "Fas-binding factor 1", "refseq_ac": "NP_001306122", "refseq_name": "fas-binding factor 1", "gene_name": "FBF1", "gene_names_uniprotkb": "FBF1; ALB; KIAA1863", "gene_names_refseq": "Alb; FBF-1; FBF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8TES7", "url": "https://www.uniprot.org/uniprotkb/Q8TES7" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs2065531223", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2065531223", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs2065531223", "url": "https://www.ensembl.org/id/rs2065531223", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SEGLHLAGTAGHPPSGSQPL", "down_seq": "STQGLEHAAAGGSSGTTARE", "snv": [ { "evidence": [ { "id": "rs2065531223", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2065531223" }, { "id": "rs2065531223", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs2065531223" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (TST->NST).", "chr_id": "17", "chr_pos": "75922035", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T465", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "373", "end_pos": "373" } ] }, { "type": "snv", "site_list": [ { "start_pos": "115", "end_pos": "115" }, { "start_pos": "1044", "end_pos": "1044" }, { "start_pos": "125", "end_pos": "125" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "373", "end_pos": "373" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "520", "end_pos": "520" }, { "start_pos": "746", "end_pos": "746" }, { "start_pos": "979", "end_pos": "979" }, { "start_pos": "97", "end_pos": "97" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "142", "end_pos": "142" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8TES7-1.520.520", "start_pos": 520, "end_pos": 520, "uniprot_canonical_ac": "Q8TES7-1", "length": 1133, "uniprot_id": "FBF1_HUMAN", "protein_name": "Fas-binding factor 1", "refseq_ac": "NP_001306122", "refseq_name": "fas-binding factor 1", "gene_name": "FBF1", "gene_names_uniprotkb": "FBF1; ALB; KIAA1863", "gene_names_refseq": "Alb; FBF-1; FBF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8TES7", "url": "https://www.uniprot.org/uniprotkb/Q8TES7" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs377305613", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs377305613", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs377305613", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs377305613", "database": "1000Genomes", "categories": [ "Other" ] }, { "id": "rs377305613", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs377305613", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs377305613", "url": "https://www.ncbi.nlm.nih.gov/snp/rs377305613#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs377305613", "url": "http://gnomad.broadinstitute.org/awesome?query=rs377305613", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "QNHAASALPTGSPKRGTAPG", "down_seq": "LSATEPATCFPSTQKPTEPS", "snv": [ { "evidence": [ { "id": "rs377305613", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs377305613" }, { "id": "rs377305613", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs377305613" }, { "id": "rs377305613", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs377305613" }, { "id": "rs377305613", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs377305613#frequency_tab" }, { "id": "rs377305613", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs377305613" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (DLS->NLS).", "chr_id": "17", "chr_pos": "75921487", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "0.000196232", "site_lbl": "D520", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "373", "end_pos": "373" } ] }, { "type": "snv", "site_list": [ { "start_pos": "115", "end_pos": "115" }, { "start_pos": "1044", "end_pos": "1044" }, { "start_pos": "125", "end_pos": "125" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "373", "end_pos": "373" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "520", "end_pos": "520" }, { "start_pos": "746", "end_pos": "746" }, { "start_pos": "979", "end_pos": "979" }, { "start_pos": "97", "end_pos": "97" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "142", "end_pos": "142" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8TES7-1.746.746", "start_pos": 746, "end_pos": 746, "uniprot_canonical_ac": "Q8TES7-1", "length": 1133, "uniprot_id": "FBF1_HUMAN", "protein_name": "Fas-binding factor 1", "refseq_ac": "NP_001306122", "refseq_name": "fas-binding factor 1", "gene_name": "FBF1", "gene_names_uniprotkb": "FBF1; ALB; KIAA1863", "gene_names_refseq": "Alb; FBF-1; FBF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8TES7", "url": "https://www.uniprot.org/uniprotkb/Q8TES7" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q8TES7", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8TES7", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs2065499851", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2065499851", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs2065499851", "url": "https://www.ncbi.nlm.nih.gov/snp/rs2065499851#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs2065499851", "url": "http://gnomad.broadinstitute.org/awesome?query=rs2065499851", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "AATSATSHTRSLNSIIHQME", "down_seq": "FSSSLHELSSRVEASHLTTS", "snv": [ { "evidence": [ { "id": "Q8TES7", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8TES7" }, { "id": "rs2065499851", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2065499851" }, { "id": "rs2065499851", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs2065499851#frequency_tab" }, { "id": "rs2065499851", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs2065499851" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "subjects_tested": "4484", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "K", "sequence_mut": "N", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (KFS->NFS).", "chr_id": "17", "chr_pos": "75918037", "ref_nt": "C", "alt_nt": "G", "minor_allelic_frequency": "", "site_lbl": "K746", "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "373", "end_pos": "373" } ] }, { "type": "snv", "site_list": [ { "start_pos": "115", "end_pos": "115" }, { "start_pos": "1044", "end_pos": "1044" }, { "start_pos": "125", "end_pos": "125" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "373", "end_pos": "373" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "520", "end_pos": "520" }, { "start_pos": "746", "end_pos": "746" }, { "start_pos": "979", "end_pos": "979" }, { "start_pos": "97", "end_pos": "97" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "142", "end_pos": "142" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8TES7-1.979.979", "start_pos": 979, "end_pos": 979, "uniprot_canonical_ac": "Q8TES7-1", "length": 1133, "uniprot_id": "FBF1_HUMAN", "protein_name": "Fas-binding factor 1", "refseq_ac": "NP_001306122", "refseq_name": "fas-binding factor 1", "gene_name": "FBF1", "gene_names_uniprotkb": "FBF1; ALB; KIAA1863", "gene_names_refseq": "Alb; FBF-1; FBF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8TES7", "url": "https://www.uniprot.org/uniprotkb/Q8TES7" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs745639394", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs745639394", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs745639394", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs745639394", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs745639394", "url": "https://www.ncbi.nlm.nih.gov/snp/rs745639394#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs745639394", "url": "http://gnomad.broadinstitute.org/awesome?query=rs745639394", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "EKERINATALRVKLRAEEVE", "down_seq": "MSKVASEKYEEGERALREAQ", "snv": [ { "evidence": [ { "id": "rs745639394", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs745639394" }, { "id": "rs745639394", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs745639394" }, { "id": "rs745639394", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs745639394#frequency_tab" }, { "id": "rs745639394", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs745639394" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (SMS->NMS).", "chr_id": "17", "chr_pos": "75914132", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S979", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "373", "end_pos": "373" } ] }, { "type": "snv", "site_list": [ { "start_pos": "115", "end_pos": "115" }, { "start_pos": "1044", "end_pos": "1044" }, { "start_pos": "125", "end_pos": "125" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "373", "end_pos": "373" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "520", "end_pos": "520" }, { "start_pos": "746", "end_pos": "746" }, { "start_pos": "979", "end_pos": "979" }, { "start_pos": "97", "end_pos": "97" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "142", "end_pos": "142" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8TES7-1.97.97", "start_pos": 97, "end_pos": 97, "uniprot_canonical_ac": "Q8TES7-1", "length": 1133, "uniprot_id": "FBF1_HUMAN", "protein_name": "Fas-binding factor 1", "refseq_ac": "NP_001306122", "refseq_name": "fas-binding factor 1", "gene_name": "FBF1", "gene_names_uniprotkb": "FBF1; ALB; KIAA1863", "gene_names_refseq": "Alb; FBF-1; FBF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8TES7", "url": "https://www.uniprot.org/uniprotkb/Q8TES7" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs2065573571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2065573571", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs2065573571", "url": "http://gnomad.broadinstitute.org/awesome?query=rs2065573571", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "A", "start_aa": "A", "up_seq": "AMKDLDGMDADILGLKKSNS", "down_seq": "PSKKAAKDPGKGELPNHPKP", "snv": [ { "evidence": [ { "id": "rs2065573571", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2065573571" }, { "id": "rs2065573571", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs2065573571" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "A", "sequence_mut": "T", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (NSA->NST).", "chr_id": "17", "chr_pos": "75928142", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A97", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "373", "end_pos": "373" } ] }, { "type": "snv", "site_list": [ { "start_pos": "115", "end_pos": "115" }, { "start_pos": "1044", "end_pos": "1044" }, { "start_pos": "125", "end_pos": "125" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "373", "end_pos": "373" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "520", "end_pos": "520" }, { "start_pos": "746", "end_pos": "746" }, { "start_pos": "979", "end_pos": "979" }, { "start_pos": "97", "end_pos": "97" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "142", "end_pos": "142" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 18, "direction": "upstream", "id": "Q8TES7-1.115.115", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8TES7-1.142.142", "start_pos": 142, "end_pos": 142, "uniprot_canonical_ac": "Q8TES7-1", "length": 1133, "uniprot_id": "FBF1_HUMAN", "protein_name": "Fas-binding factor 1", "refseq_ac": "NP_001306122", "refseq_name": "fas-binding factor 1", "gene_name": "FBF1", "gene_names_uniprotkb": "FBF1; ALB; KIAA1863", "gene_names_refseq": "Alb; FBF-1; FBF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8TES7", "url": "https://www.uniprot.org/uniprotkb/Q8TES7" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "Q8TES7", "url": "https://www.uniprot.org/uniprotkb/Q8TES7" }, { "database": "iPTMnet", "id": "Q8TES7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8TES7" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] } ], "crossref": [ { "id": "Q8TES7", "url": "https://www.uniprot.org/uniprotkb/Q8TES7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q8TES7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8TES7", "database": "iPTMnet", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "IPTKKSLPSPSSSGHQNRRF", "down_seq": "SEDLEDPLRGLLSYDEGGIT", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8TES7", "url": "https://www.uniprot.org/uniprotkb/Q8TES7" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "Q8TES7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8TES7" } ], "site_lbl": "Ser142" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "373", "end_pos": "373" } ] }, { "type": "snv", "site_list": [ { "start_pos": "115", "end_pos": "115" }, { "start_pos": "1044", "end_pos": "1044" }, { "start_pos": "125", "end_pos": "125" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "373", "end_pos": "373" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "520", "end_pos": "520" }, { "start_pos": "746", "end_pos": "746" }, { "start_pos": "979", "end_pos": "979" }, { "start_pos": "97", "end_pos": "97" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "142", "end_pos": "142" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 17, "direction": "downstream", "id": "Q8TES7-1.125.125", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q8TES7-1.140.140", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q8NAC3-1.189.189", "start_pos": 189, "end_pos": 189, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "rs1342476435", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1342476435", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1342476435", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1342476435", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "Q8NAC3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8NAC3", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "EPEDEEKFGGAADSGVEEPR", "down_seq": "ASLQAQVVLSFQAYPTARCV", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn189", "evidence": [ { "id": "Q8NAC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3#ptm_processing" } ] } ], "snv": [ { "evidence": [ { "id": "rs1342476435", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1342476435" }, { "id": "rs1342476435", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1342476435" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NAS->SAS).", "chr_id": "3", "chr_pos": "9918407", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N189", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "Q8NAC3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8NAC3" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "subjects_tested": "1704", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "N", "sequence_mut": "T", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-loss (NAS->TAS).", "chr_id": "3", "chr_pos": "9918407", "ref_nt": "A", "alt_nt": "C", "minor_allelic_frequency": "", "site_lbl": "N189", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "upstream", "id": "Q8NAC3-1.191.191", "categories": [ "snv_flag" ] }, { "distance": 18, "direction": "upstream", "id": "Q8NAC3-1.207.207", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.257.257", "start_pos": 257, "end_pos": 257, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Deep quantitative glycoproteomics reveals gut microbiome induced remodeling of the brain glycoproteome", "journal": "bioRxiv", "date": "2023", "authors": "Potel C.M., Burtscher M.L., Garrido-Rodriguez M., Brauer-Nikonow A., Becher I., Typas A., Zimmermann M., Savitski M.", "evidence": [ { "database": "Data Submission", "id": "GLY_000888", "url": "http://data.glygen.org/GLY_000888" } ], "reference": [ { "type": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" } ] } ], "crossref": [ { "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529", "database": "DOI", "categories": [ "Other" ] }, { "id": "GLY_000888", "url": "http://data.glygen.org/GLY_000888", "database": "Data Submission", "categories": [ "Other" ] }, { "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "7UWN", "url": "https://www.rcsb.org/structure/7UWN", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7UWN|G|186", "url": "", "database": "", "categories": [ "Other" ] }, { "id": "rs2470142949", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2470142949", "database": "dbSNP", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "ALGSEVRIWSYTQPRYEKEL", "down_seq": "HTQQLPDCRGLEVWNSIPSC", "glycosylation": [ { "glytoucan_ac": "G80920RR", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "ELNHTQQLPDCR", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn257", "evidence": [ { "id": "10.1101/2023.09.13.557529", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "id": "GLY_000888", "database": "Data Submission", "url": "http://data.glygen.org/GLY_000888" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": { "label": "iCn3D", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?bcifid=7UWN&bu=0&command=select+.G:186;+center+selection;+zoom+selection" }, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn257", "evidence": [ { "id": "Q8NAC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3#ptm_processing" }, { "id": "7UWN", "database": "PDB", "url": "https://www.rcsb.org/structure/7UWN" } ] } ], "snv": [ { "evidence": [ { "id": "rs2470142949", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2470142949" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NHT->SHT).", "chr_id": "3", "chr_pos": "9920582", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N257", "disease": [ { "disease_id": "DOID:2058", "recommended_name": { "id": "DOID:2058", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2058", "name": "chronic mucocutaneous candidiasis", "description": "A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp." }, "synonyms": [ { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "CANDF1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1, autosomal dominant", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "predisposition to invasive fungal disease due to CARD9 deficiency", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, 2, autosomal recessive", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, type 2", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "invasive candidiasis-deep dermatophytosis syndrome", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "CANDF2", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "CARD9 deficiency", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis familial chronic mucocutaneous, autosomal recessive", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, 2", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "candidiasis, familial, 3", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "CANDF3", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "candidiasis, familial, 3", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4", "description": "Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the CLEC7A gene." }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "CLEC7A familial chronic mucocutaneous candidiasis", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4, autosomal recessive", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, type 4", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "familial chronic mucocutaneous candidiasis caused by mutation in CLEC7A", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "CANDF4", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6", "description": "Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17F gene." }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "IL17F familial chronic mucocutaneous candidiasis", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6, autosomal dominant", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, type 6", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "familial chronic mucocutaneous candidiasis caused by mutation in IL17F", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "CANDF6", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, 8", "description": "Any chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the TRAF3IP2 gene." }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "TRAF3IP2 chronic mucocutaneous candidiasis (disease)", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, 8", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, type 8", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "chronic mucocutaneous candidiasis (disease) caused by mutation in TRAF3IP2", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "CANDF8", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, 9", "description": "Any chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17RC gene." }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "IL17RC chronic mucocutaneous candidiasis (disease)", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, 9", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, type 9", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "chronic mucocutaneous candidiasis (disease) caused by mutation in IL17RC", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "CANDF9", "description": "" }, { "id": "MIM:212050", "resource": "MIM", "url": "https://www.omim.org/entry/212050", "name": "Immunodeficiency 103, susceptibility to fungal infections", "description": "Immunodeficiency 103, susceptibility to fungal infections" }, { "id": "MIM:613108", "resource": "MIM", "url": "https://www.omim.org/entry/613108", "name": "Candidiasis, familial, 4", "description": "Candidiasis, familial, 4" }, { "id": "MIM:613956", "resource": "MIM", "url": "https://www.omim.org/entry/613956", "name": "Candidiasis, familial, 6", "description": "Candidiasis, familial, 6" }, { "id": "MIM:615527", "resource": "MIM", "url": "https://www.omim.org/entry/615527", "name": "Candidiasis, familial, 8", "description": "Candidiasis, familial, 8" }, { "id": "MIM:616445", "resource": "MIM", "url": "https://www.omim.org/entry/616445", "name": "Candidiasis, familial, 9", "description": "Candidiasis, familial, 9" } ], "unlinked_id_list": [], "evidence": [ { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" }, { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" }, { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" } ] } ], "keywords": [ "ebi", "germline", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 14, "direction": "downstream", "id": "Q8NAC3-1.243.243", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q8NAC3-1.259.259", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl", "icn3d_view.label", "icn3d_view.url" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl", "icn3d_view.label", "icn3d_view.url" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl", "icn3d_view.label", "icn3d_view.url" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q8NAC3-1.284.284", "start_pos": 284, "end_pos": 284, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "7UWN", "url": "https://www.rcsb.org/structure/7UWN", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7ZAN", "url": "https://www.rcsb.org/structure/7ZAN", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7UWN|G|213", "url": "", "database": "", "categories": [ "Other" ] }, { "id": "7ZAN|D|213", "url": "", "database": "", "categories": [ "Other" ] }, { "id": "rs201753733", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs201753733", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs201753733", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs201753733", "database": "1000Genomes", "categories": [ "Other" ] }, { "id": "rs201753733", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs201753733", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs201753733", "url": "https://www.ncbi.nlm.nih.gov/snp/rs201753733#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs201753733", "url": "http://gnomad.broadinstitute.org/awesome?query=rs201753733", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "rs1575584322", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1575584322", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1575584322", "url": "https://www.ensembl.org/id/rs1575584322", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "DCRGLEVWNSIPSCWALPWL", "down_seq": "VSADGDNVHLVLNVSEEQHF", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": { "label": "iCn3D", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?bcifid=7UWN&bu=0&command=select+.G:213;+center+selection;+zoom+selection" }, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn284", "evidence": [ { "id": "Q8NAC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3#ptm_processing" }, { "id": "7UWN", "database": "PDB", "url": "https://www.rcsb.org/structure/7UWN" }, { "id": "7ZAN", "database": "PDB", "url": "https://www.rcsb.org/structure/7ZAN" } ] } ], "snv": [ { "evidence": [ { "id": "rs201753733", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs201753733" }, { "id": "rs201753733", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs201753733" }, { "id": "rs201753733", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs201753733" }, { "id": "rs201753733", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs201753733#frequency_tab" }, { "id": "rs201753733", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs201753733" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "N", "sequence_mut": "D", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NVS->DVS).", "chr_id": "3", "chr_pos": "9928322", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "0.000196232", "site_lbl": "N284", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1575584322", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1575584322" }, { "id": "rs1575584322", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1575584322" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NVS->SVS).", "chr_id": "3", "chr_pos": "9928323", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N284", "disease": [ { "disease_id": "DOID:2058", "recommended_name": { "id": "DOID:2058", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2058", "name": "chronic mucocutaneous candidiasis", "description": "A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp." }, "synonyms": [ { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "CANDF1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1, autosomal dominant", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "predisposition to invasive fungal disease due to CARD9 deficiency", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, 2, autosomal recessive", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, type 2", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "invasive candidiasis-deep dermatophytosis syndrome", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "CANDF2", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "CARD9 deficiency", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis familial chronic mucocutaneous, autosomal recessive", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, 2", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "candidiasis, familial, 3", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "CANDF3", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "candidiasis, familial, 3", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4", "description": "Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the CLEC7A gene." }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "CLEC7A familial chronic mucocutaneous candidiasis", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4, autosomal recessive", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, type 4", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "familial chronic mucocutaneous candidiasis caused by mutation in CLEC7A", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "CANDF4", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6", "description": "Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17F gene." }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "IL17F familial chronic mucocutaneous candidiasis", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6, autosomal dominant", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, type 6", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "familial chronic mucocutaneous candidiasis caused by mutation in IL17F", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "CANDF6", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, 8", "description": "Any chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the TRAF3IP2 gene." }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "TRAF3IP2 chronic mucocutaneous candidiasis (disease)", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, 8", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, type 8", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "chronic mucocutaneous candidiasis (disease) caused by mutation in TRAF3IP2", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "CANDF8", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, 9", "description": "Any chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17RC gene." }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "IL17RC chronic mucocutaneous candidiasis (disease)", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, 9", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, type 9", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "chronic mucocutaneous candidiasis (disease) caused by mutation in IL17RC", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "CANDF9", "description": "" }, { "id": "MIM:212050", "resource": "MIM", "url": "https://www.omim.org/entry/212050", "name": "Immunodeficiency 103, susceptibility to fungal infections", "description": "Immunodeficiency 103, susceptibility to fungal infections" }, { "id": "MIM:613108", "resource": "MIM", "url": "https://www.omim.org/entry/613108", "name": "Candidiasis, familial, 4", "description": "Candidiasis, familial, 4" }, { "id": "MIM:613956", "resource": "MIM", "url": "https://www.omim.org/entry/613956", "name": "Candidiasis, familial, 6", "description": "Candidiasis, familial, 6" }, { "id": "MIM:615527", "resource": "MIM", "url": "https://www.omim.org/entry/615527", "name": "Candidiasis, familial, 8", "description": "Candidiasis, familial, 8" }, { "id": "MIM:616445", "resource": "MIM", "url": "https://www.omim.org/entry/616445", "name": "Candidiasis, familial, 9", "description": "Candidiasis, familial, 9" } ], "unlinked_id_list": [], "evidence": [ { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" }, { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" }, { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" } ] } ], "keywords": [ "ebi", "germline", "disease" ] }, { "evidence": [ { "id": "rs1575584322", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1575584322" }, { "id": "rs1575584322", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1575584322" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "N", "sequence_mut": "T", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NVS->TVS).", "chr_id": "3", "chr_pos": "9928323", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N284", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 1, "direction": "upstream", "id": "Q8NAC3-1.285.285", "categories": [ "snv_flag" ] }, { "distance": 13, "direction": "upstream", "id": "Q8NAC3-1.297.297", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "icn3d_view.label", "icn3d_view.url", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "icn3d_view.label", "icn3d_view.url", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.297.297", "start_pos": 297, "end_pos": 297, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "7ZAN", "url": "https://www.rcsb.org/structure/7ZAN", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7ZAN|D|226", "url": "", "database": "", "categories": [ "Other" ] }, { "id": "rs1180663342", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1180663342", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1180663342", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1180663342", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "CWALPWLNVSADGDNVHLVL", "down_seq": "VSEEQHFGLSLYWNQVQGPP", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": { "label": "iCn3D", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?bcifid=7ZAN&bu=0&command=select+.D:226;+center+selection;+zoom+selection" }, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn297", "evidence": [ { "id": "Q8NAC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3#ptm_processing" }, { "id": "7ZAN", "database": "PDB", "url": "https://www.rcsb.org/structure/7ZAN" } ] } ], "snv": [ { "evidence": [ { "id": "rs1180663342", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1180663342" }, { "id": "rs1180663342", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1180663342" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "N", "sequence_mut": "K", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NVS->KVS).", "chr_id": "3", "chr_pos": "9923936", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N297", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 13, "direction": "downstream", "id": "Q8NAC3-1.284.284", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 12, "direction": "downstream", "id": "Q8NAC3-1.285.285", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "icn3d_view.label", "icn3d_view.url", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "icn3d_view.label", "icn3d_view.url", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.324.324", "start_pos": 324, "end_pos": 324, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "6HGA", "url": "https://www.rcsb.org/structure/6HGA", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6HGA|B|253", "url": "", "database": "", "categories": [ "Other" ] }, { "id": "rs768507483", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs768507483", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs768507483", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs768507483", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs768507483", "url": "http://gnomad.broadinstitute.org/awesome?query=rs768507483", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "FGLSLYWNQVQGPPKPRWHK", "down_seq": "LTGPQIITLNHTDLVPCLCI", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": { "label": "iCn3D", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?bcifid=6HGA&bu=0&command=select+.B:253;+center+selection;+zoom+selection" }, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn324", "evidence": [ { "id": "Q8NAC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3#ptm_processing" }, { "id": "6HGA", "database": "PDB", "url": "https://www.rcsb.org/structure/6HGA" } ] } ], "snv": [ { "evidence": [ { "id": "rs768507483", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs768507483" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "N", "sequence_mut": "D", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NLT->DLT).", "chr_id": "3", "chr_pos": "9924015", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N324", "disease": [ { "disease_id": "DOID:2058", "recommended_name": { "id": "DOID:2058", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2058", "name": "chronic mucocutaneous candidiasis", "description": "A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp." }, "synonyms": [ { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "CANDF1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1, autosomal dominant", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "predisposition to invasive fungal disease due to CARD9 deficiency", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, 2, autosomal recessive", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, type 2", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "invasive candidiasis-deep dermatophytosis syndrome", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "CANDF2", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "CARD9 deficiency", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis familial chronic mucocutaneous, autosomal recessive", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, 2", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "candidiasis, familial, 3", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "CANDF3", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "candidiasis, familial, 3", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4", "description": "Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the CLEC7A gene." }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "CLEC7A familial chronic mucocutaneous candidiasis", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4, autosomal recessive", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, type 4", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "familial chronic mucocutaneous candidiasis caused by mutation in CLEC7A", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "CANDF4", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6", "description": "Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17F gene." }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "IL17F familial chronic mucocutaneous candidiasis", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6, autosomal dominant", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, type 6", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "familial chronic mucocutaneous candidiasis caused by mutation in IL17F", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "CANDF6", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, 8", "description": "Any chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the TRAF3IP2 gene." }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "TRAF3IP2 chronic mucocutaneous candidiasis (disease)", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, 8", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, type 8", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "chronic mucocutaneous candidiasis (disease) caused by mutation in TRAF3IP2", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "CANDF8", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, 9", "description": "Any chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17RC gene." }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "IL17RC chronic mucocutaneous candidiasis (disease)", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, 9", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, type 9", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "chronic mucocutaneous candidiasis (disease) caused by mutation in IL17RC", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "CANDF9", "description": "" }, { "id": "MIM:212050", "resource": "MIM", "url": "https://www.omim.org/entry/212050", "name": "Immunodeficiency 103, susceptibility to fungal infections", "description": "Immunodeficiency 103, susceptibility to fungal infections" }, { "id": "MIM:613108", "resource": "MIM", "url": "https://www.omim.org/entry/613108", "name": "Candidiasis, familial, 4", "description": "Candidiasis, familial, 4" }, { "id": "MIM:613956", "resource": "MIM", "url": "https://www.omim.org/entry/613956", "name": "Candidiasis, familial, 6", "description": "Candidiasis, familial, 6" }, { "id": "MIM:615527", "resource": "MIM", "url": "https://www.omim.org/entry/615527", "name": "Candidiasis, familial, 8", "description": "Candidiasis, familial, 8" }, { "id": "MIM:616445", "resource": "MIM", "url": "https://www.omim.org/entry/616445", "name": "Candidiasis, familial, 9", "description": "Candidiasis, familial, 9" } ], "unlinked_id_list": [], "evidence": [ { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" }, { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" }, { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" } ] } ], "keywords": [ "ebi", "germline", "disease" ] }, { "evidence": [ { "id": "rs768507483", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs768507483" }, { "id": "rs768507483", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs768507483" }, { "id": "rs768507483", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs768507483" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "N", "sequence_mut": "H", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NLT->HLT).", "chr_id": "3", "chr_pos": "9924015", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N324", "disease": [ { "disease_id": "DOID:2058", "recommended_name": { "id": "DOID:2058", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2058", "name": "chronic mucocutaneous candidiasis", "description": "A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp." }, "synonyms": [ { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "CANDF1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1, autosomal dominant", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "predisposition to invasive fungal disease due to CARD9 deficiency", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, 2, autosomal recessive", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, type 2", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "invasive candidiasis-deep dermatophytosis syndrome", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "CANDF2", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "CARD9 deficiency", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis familial chronic mucocutaneous, autosomal recessive", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, 2", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "candidiasis, familial, 3", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "CANDF3", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "candidiasis, familial, 3", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4", "description": "Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the CLEC7A gene." }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "CLEC7A familial chronic mucocutaneous candidiasis", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4, autosomal recessive", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, type 4", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "familial chronic mucocutaneous candidiasis caused by mutation in CLEC7A", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "CANDF4", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6", "description": "Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17F gene." }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "IL17F familial chronic mucocutaneous candidiasis", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6, autosomal dominant", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, type 6", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "familial chronic mucocutaneous candidiasis caused by mutation in IL17F", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "CANDF6", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, 8", "description": "Any chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the TRAF3IP2 gene." }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "TRAF3IP2 chronic mucocutaneous candidiasis (disease)", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, 8", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, type 8", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "chronic mucocutaneous candidiasis (disease) caused by mutation in TRAF3IP2", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "CANDF8", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, 9", "description": "Any chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17RC gene." }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "IL17RC chronic mucocutaneous candidiasis (disease)", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, 9", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, type 9", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "chronic mucocutaneous candidiasis (disease) caused by mutation in IL17RC", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "CANDF9", "description": "" }, { "id": "MIM:212050", "resource": "MIM", "url": "https://www.omim.org/entry/212050", "name": "Immunodeficiency 103, susceptibility to fungal infections", "description": "Immunodeficiency 103, susceptibility to fungal infections" }, { "id": "MIM:613108", "resource": "MIM", "url": "https://www.omim.org/entry/613108", "name": "Candidiasis, familial, 4", "description": "Candidiasis, familial, 4" }, { "id": "MIM:613956", "resource": "MIM", "url": "https://www.omim.org/entry/613956", "name": "Candidiasis, familial, 6", "description": "Candidiasis, familial, 6" }, { "id": "MIM:615527", "resource": "MIM", "url": "https://www.omim.org/entry/615527", "name": "Candidiasis, familial, 8", "description": "Candidiasis, familial, 8" }, { "id": "MIM:616445", "resource": "MIM", "url": "https://www.omim.org/entry/616445", "name": "Candidiasis, familial, 9", "description": "Candidiasis, familial, 9" } ], "unlinked_id_list": [], "evidence": [ { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" }, { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" }, { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" } ] } ], "keywords": [ "ebi", "germline", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 1, "direction": "upstream", "id": "Q8NAC3-1.325.325", "categories": [ "snv_flag" ] }, { "distance": 10, "direction": "upstream", "id": "Q8NAC3-1.334.334", "categories": [ "glycosylation_flag" ] }, { "distance": 12, "direction": "upstream", "id": "Q8NAC3-1.336.336", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "icn3d_view.label", "icn3d_view.url", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "icn3d_view.label", "icn3d_view.url", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.334.334", "start_pos": 334, "end_pos": 334, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "QGPPKPRWHKNLTGPQIITL", "down_seq": "HTDLVPCLCIQVWPLEPDSV", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn334", "evidence": [ { "id": "Q8NAC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3#ptm_processing" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 10, "direction": "downstream", "id": "Q8NAC3-1.324.324", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 9, "direction": "downstream", "id": "Q8NAC3-1.325.325", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q8NAC3-1.336.336", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.420.420", "start_pos": 420, "end_pos": 420, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "7ZAN", "url": "https://www.rcsb.org/structure/7ZAN", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7ZAN|D|349", "url": "", "database": "", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "CWRAPGGDPCQPLVPPLSWE", "down_seq": "VTVDKVLEFPLLKGHPNLCV", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": { "label": "iCn3D", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?bcifid=7ZAN&bu=0&command=select+.D:349;+center+selection;+zoom+selection" }, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn420", "evidence": [ { "id": "Q8NAC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3#ptm_processing" }, { "id": "7ZAN", "database": "PDB", "url": "https://www.rcsb.org/structure/7ZAN" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "upstream", "id": "Q8NAC3-1.422.422", "categories": [ "snv_flag" ] }, { "distance": 7, "direction": "upstream", "id": "Q8NAC3-1.427.427", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "icn3d_view.label", "icn3d_view.url", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "icn3d_view.label", "icn3d_view.url", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.443.443", "start_pos": 443, "end_pos": 443, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Deep quantitative glycoproteomics reveals gut microbiome induced remodeling of the brain glycoproteome", "journal": "bioRxiv", "date": "2023", "authors": "Potel C.M., Burtscher M.L., Garrido-Rodriguez M., Brauer-Nikonow A., Becher I., Typas A., Zimmermann M., Savitski M.", "evidence": [ { "database": "Data Submission", "id": "GLY_000888", "url": "http://data.glygen.org/GLY_000888" } ], "reference": [ { "type": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" } ] } ], "crossref": [ { "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529", "database": "DOI", "categories": [ "Other" ] }, { "id": "GLY_000888", "url": "http://data.glygen.org/GLY_000888", "database": "Data Submission", "categories": [ "Other" ] }, { "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "rs2084486609", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2084486609", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs2084486609", "url": "https://www.ensembl.org/id/rs2084486609", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "VDKVLEFPLLKGHPNLCVQV", "down_seq": "SSEKLQLQECLWADSLGPLK", "glycosylation": [ { "glytoucan_ac": "G80920RR", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "GHPNLCVQVNSSEK", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn443", "evidence": [ { "id": "10.1101/2023.09.13.557529", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "id": "GLY_000888", "database": "Data Submission", "url": "http://data.glygen.org/GLY_000888" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn443", "evidence": [ { "id": "Q8NAC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3#ptm_processing" } ] } ], "snv": [ { "evidence": [ { "id": "rs2084486609", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2084486609" }, { "id": "rs2084486609", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs2084486609" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "N", "sequence_mut": "Y", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NSS->YSS).", "chr_id": "3", "chr_pos": "9929855", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N443", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 16, "direction": "downstream", "id": "Q8NAC3-1.427.427", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q8NAC3-1.445.445", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q8NAC3-1.477.477", "start_pos": 477, "end_pos": 477, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "DSLGPLKDDVLLLETRGPQD", "down_seq": "RSLCALEPSGCTSLPSKAST", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn477", "evidence": [ { "id": "Q8NAC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3#ptm_processing" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 9, "direction": "upstream", "id": "Q8NAC3-1.486.486", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.149.149", "start_pos": 149, "end_pos": 149, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs759641491", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs759641491", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs759641491", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs759641491", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs759641491", "url": "http://gnomad.broadinstitute.org/awesome?query=rs759641491", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GPVLAPTHLQTELVLRCQKE", "down_seq": "DCDLCLRVAVHLAVHGHWEE", "snv": [ { "evidence": [ { "id": "rs759641491", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs759641491" }, { "id": "rs759641491", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs759641491" }, { "id": "rs759641491", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs759641491" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (TDC->NDC).", "chr_id": "3", "chr_pos": "9918028", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T149", "disease": [ { "disease_id": "DOID:2058", "recommended_name": { "id": "DOID:2058", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2058", "name": "chronic mucocutaneous candidiasis", "description": "A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp." }, "synonyms": [ { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "CANDF1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1, autosomal dominant", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "predisposition to invasive fungal disease due to CARD9 deficiency", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, 2, autosomal recessive", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, type 2", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "invasive candidiasis-deep dermatophytosis syndrome", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "CANDF2", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "CARD9 deficiency", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis familial chronic mucocutaneous, autosomal recessive", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, 2", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "candidiasis, familial, 3", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "CANDF3", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "candidiasis, familial, 3", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4", "description": "Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the CLEC7A gene." }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "CLEC7A familial chronic mucocutaneous candidiasis", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4, autosomal recessive", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, type 4", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "familial chronic mucocutaneous candidiasis caused by mutation in CLEC7A", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "CANDF4", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6", "description": "Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17F gene." }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "IL17F familial chronic mucocutaneous candidiasis", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6, autosomal dominant", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, type 6", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "familial chronic mucocutaneous candidiasis caused by mutation in IL17F", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "CANDF6", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, 8", "description": "Any chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the TRAF3IP2 gene." }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "TRAF3IP2 chronic mucocutaneous candidiasis (disease)", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, 8", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, type 8", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "chronic mucocutaneous candidiasis (disease) caused by mutation in TRAF3IP2", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "CANDF8", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, 9", "description": "Any chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17RC gene." }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "IL17RC chronic mucocutaneous candidiasis (disease)", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, 9", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, type 9", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "chronic mucocutaneous candidiasis (disease) caused by mutation in IL17RC", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "CANDF9", "description": "" }, { "id": "MIM:212050", "resource": "MIM", "url": "https://www.omim.org/entry/212050", "name": "Immunodeficiency 103, susceptibility to fungal infections", "description": "Immunodeficiency 103, susceptibility to fungal infections" }, { "id": "MIM:613108", "resource": "MIM", "url": "https://www.omim.org/entry/613108", "name": "Candidiasis, familial, 4", "description": "Candidiasis, familial, 4" }, { "id": "MIM:613956", "resource": "MIM", "url": "https://www.omim.org/entry/613956", "name": "Candidiasis, familial, 6", "description": "Candidiasis, familial, 6" }, { "id": "MIM:615527", "resource": "MIM", "url": "https://www.omim.org/entry/615527", "name": "Candidiasis, familial, 8", "description": "Candidiasis, familial, 8" }, { "id": "MIM:616445", "resource": "MIM", "url": "https://www.omim.org/entry/616445", "name": "Candidiasis, familial, 9", "description": "Candidiasis, familial, 9" } ], "unlinked_id_list": [], "evidence": [ { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" }, { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" }, { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" } ] } ], "keywords": [ "ebi", "germline", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 1, "direction": "upstream", "id": "Q8NAC3-1.150.150", "categories": [ "snv_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q8NAC3-1.152.152", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.150.150", "start_pos": 150, "end_pos": 150, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q8NAC3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8NAC3", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "PVLAPTHLQTELVLRCQKET", "down_seq": "CDLCLRVAVHLAVHGHWEEP", "snv": [ { "evidence": [ { "id": "Q8NAC3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8NAC3" } ], "glycoeffect": [], "subjects_tested": "1773", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "3", "chr_pos": "9918030", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "D150", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 1, "direction": "downstream", "id": "Q8NAC3-1.149.149", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q8NAC3-1.152.152", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.152.152", "start_pos": 152, "end_pos": 152, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1327447454", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1327447454", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1327447454", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1327447454", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "LAPTHLQTELVLRCQKETDC", "down_seq": "LCLRVAVHLAVHGHWEEPED", "snv": [ { "evidence": [ { "id": "rs1327447454", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1327447454" }, { "id": "rs1327447454", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1327447454" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (DLC->NLC).", "chr_id": "3", "chr_pos": "9918036", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D152", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 3, "direction": "downstream", "id": "Q8NAC3-1.149.149", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q8NAC3-1.150.150", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.191.191", "start_pos": 191, "end_pos": 191, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs2125128535", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2125128535", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs2125128535", "url": "https://www.ensembl.org/id/rs2125128535", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "EDEEKFGGAADSGVEEPRNA", "down_seq": "LQAQVVLSFQAYPTARCVLL", "snv": [ { "evidence": [ { "id": "rs2125128535", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2125128535" }, { "id": "rs2125128535", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs2125128535" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "Y", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NAS->NAY).", "chr_id": "3", "chr_pos": "9918503", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S191", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "downstream", "id": "Q8NAC3-1.189.189", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 16, "direction": "upstream", "id": "Q8NAC3-1.207.207", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.207.207", "start_pos": 207, "end_pos": 207, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q8NAC3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8NAC3", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "PRNASLQAQVVLSFQAYPTA", "down_seq": "CVLLEVQVPAALVQFGQSVG", "snv": [ { "evidence": [ { "id": "Q8NAC3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8NAC3" } ], "glycoeffect": [], "subjects_tested": "720", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "R", "sequence_mut": "C", "comment": "Somatic mutation passed 1 filters: num. of cancers (4).", "chr_id": "3", "chr_pos": "9918550", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "R207", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ], "unlinked_id_list": [ "DOID:1542" ], "evidence": [ { "id": "11934", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11934" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 18, "direction": "downstream", "id": "Q8NAC3-1.189.189", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 16, "direction": "downstream", "id": "Q8NAC3-1.191.191", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.235.235", "start_pos": 235, "end_pos": 235, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q8NAC3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8NAC3", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "E", "start_aa": "E", "up_seq": "VPAALVQFGQSVGSVVYDCF", "down_seq": "AALGSEVRIWSYTQPRYEKE", "snv": [ { "evidence": [ { "id": "Q8NAC3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8NAC3" } ], "glycoeffect": [], "subjects_tested": "3601", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "E", "sequence_mut": "K", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "3", "chr_pos": "9920515", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "E235", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 8, "direction": "upstream", "id": "Q8NAC3-1.243.243", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.243.243", "start_pos": 243, "end_pos": 243, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q8NAC3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8NAC3", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "GQSVGSVVYDCFEAALGSEV", "down_seq": "IWSYTQPRYEKELNHTQQLP", "snv": [ { "evidence": [ { "id": "Q8NAC3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8NAC3" } ], "glycoeffect": [], "subjects_tested": "4177", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "Q", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "3", "chr_pos": "9920540", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "R243", "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 8, "direction": "downstream", "id": "Q8NAC3-1.235.235", "categories": [ "snv_flag" ] }, { "distance": 14, "direction": "upstream", "id": "Q8NAC3-1.257.257", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 16, "direction": "upstream", "id": "Q8NAC3-1.259.259", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.259.259", "start_pos": 259, "end_pos": 259, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs2083456064", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2083456064", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs2083456064", "url": "https://www.ncbi.nlm.nih.gov/snp/rs2083456064#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs2083456064", "url": "http://gnomad.broadinstitute.org/awesome?query=rs2083456064", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GSEVRIWSYTQPRYEKELNH", "down_seq": "QQLPDCRGLEVWNSIPSCWA", "snv": [ { "evidence": [ { "id": "rs2083456064", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2083456064" }, { "id": "rs2083456064", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs2083456064#frequency_tab" }, { "id": "rs2083456064", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs2083456064" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NHT->NHI).", "chr_id": "3", "chr_pos": "9920588", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T259", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs2083456064", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2083456064" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "sequence_org": "T", "sequence_mut": "K", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NHT->NHK).", "chr_id": "3", "chr_pos": "9920588", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T259", "disease": [ { "disease_id": "DOID:2058", "recommended_name": { "id": "DOID:2058", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2058", "name": "chronic mucocutaneous candidiasis", "description": "A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp." }, "synonyms": [ { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "CANDF1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1, autosomal dominant", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "predisposition to invasive fungal disease due to CARD9 deficiency", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, 2, autosomal recessive", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, type 2", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "invasive candidiasis-deep dermatophytosis syndrome", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "CANDF2", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "CARD9 deficiency", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis familial chronic mucocutaneous, autosomal recessive", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, 2", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "candidiasis, familial, 3", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "CANDF3", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "candidiasis, familial, 3", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4", "description": "Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the CLEC7A gene." }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "CLEC7A familial chronic mucocutaneous candidiasis", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4, autosomal recessive", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, type 4", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "familial chronic mucocutaneous candidiasis caused by mutation in CLEC7A", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "CANDF4", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6", "description": "Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17F gene." }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "IL17F familial chronic mucocutaneous candidiasis", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6, autosomal dominant", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, type 6", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "familial chronic mucocutaneous candidiasis caused by mutation in IL17F", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "CANDF6", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, 8", "description": "Any chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the TRAF3IP2 gene." }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "TRAF3IP2 chronic mucocutaneous candidiasis (disease)", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, 8", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, type 8", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "chronic mucocutaneous candidiasis (disease) caused by mutation in TRAF3IP2", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "CANDF8", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, 9", "description": "Any chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17RC gene." }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "IL17RC chronic mucocutaneous candidiasis (disease)", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, 9", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, type 9", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "chronic mucocutaneous candidiasis (disease) caused by mutation in IL17RC", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "CANDF9", "description": "" }, { "id": "MIM:212050", "resource": "MIM", "url": "https://www.omim.org/entry/212050", "name": "Immunodeficiency 103, susceptibility to fungal infections", "description": "Immunodeficiency 103, susceptibility to fungal infections" }, { "id": "MIM:613108", "resource": "MIM", "url": "https://www.omim.org/entry/613108", "name": "Candidiasis, familial, 4", "description": "Candidiasis, familial, 4" }, { "id": "MIM:613956", "resource": "MIM", "url": "https://www.omim.org/entry/613956", "name": "Candidiasis, familial, 6", "description": "Candidiasis, familial, 6" }, { "id": "MIM:615527", "resource": "MIM", "url": "https://www.omim.org/entry/615527", "name": "Candidiasis, familial, 8", "description": "Candidiasis, familial, 8" }, { "id": "MIM:616445", "resource": "MIM", "url": "https://www.omim.org/entry/616445", "name": "Candidiasis, familial, 9", "description": "Candidiasis, familial, 9" } ], "unlinked_id_list": [], "evidence": [ { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" }, { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" }, { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" } ] } ], "keywords": [ "ebi", "germline", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 16, "direction": "downstream", "id": "Q8NAC3-1.243.243", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q8NAC3-1.257.257", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.285.285", "start_pos": 285, "end_pos": 285, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q8NAC3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8NAC3", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "V", "start_aa": "V", "up_seq": "CRGLEVWNSIPSCWALPWLN", "down_seq": "SADGDNVHLVLNVSEEQHFG", "snv": [ { "evidence": [ { "id": "Q8NAC3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8NAC3" } ], "glycoeffect": [], "subjects_tested": "9251", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "V", "sequence_mut": "M", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "3", "chr_pos": "9923898", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "V285", "disease": [ { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematological tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "blood cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:0081452", "DOID:706", "DOID:1039", "DOID:5604", "DOID:6536", "DOID:0080638", "DOID:7757", "DOID:0050743", "DOID:4960", "DOID:8527", "DOID:1036", "DOID:5772" ], "evidence": [ { "id": "2531", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2531" } ] }, { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3675", "DOID:4455" ], "evidence": [ { "id": "263", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:263" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 1, "direction": "downstream", "id": "Q8NAC3-1.284.284", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 12, "direction": "upstream", "id": "Q8NAC3-1.297.297", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.325.325", "start_pos": 325, "end_pos": 325, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs2083829190", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2083829190", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs2083829190", "url": "https://www.ensembl.org/id/rs2083829190", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "L", "start_aa": "L", "up_seq": "GLSLYWNQVQGPPKPRWHKN", "down_seq": "TGPQIITLNHTDLVPCLCIQ", "snv": [ { "evidence": [ { "id": "rs2083829190", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2083829190" }, { "id": "rs2083829190", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs2083829190" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "L", "sequence_mut": "P", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NLT->NPT).", "chr_id": "3", "chr_pos": "9924019", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "L325", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 1, "direction": "downstream", "id": "Q8NAC3-1.324.324", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 9, "direction": "upstream", "id": "Q8NAC3-1.334.334", "categories": [ "glycosylation_flag" ] }, { "distance": 11, "direction": "upstream", "id": "Q8NAC3-1.336.336", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.336.336", "start_pos": 336, "end_pos": 336, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs780936831", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs780936831", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs780936831", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs780936831", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs780936831", "url": "http://gnomad.broadinstitute.org/awesome?query=rs780936831", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "rs568856493", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs568856493", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs568856493", "url": "https://www.ncbi.nlm.nih.gov/snp/rs568856493#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs2083857302", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2083857302", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs2083857302", "url": "https://www.ensembl.org/id/rs2083857302", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PPKPRWHKNLTGPQIITLNH", "down_seq": "DLVPCLCIQVWPLEPDSVRT", "snv": [ { "evidence": [ { "id": "rs780936831", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs780936831" }, { "id": "rs780936831", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs780936831" }, { "id": "rs780936831", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs780936831" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NHT->NHA).", "chr_id": "3", "chr_pos": "9924262", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T336", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs568856493", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs568856493" }, { "id": "rs568856493", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs568856493#frequency_tab" }, { "id": "rs2083857302", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2083857302" }, { "id": "rs2083857302", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs2083857302" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NHT->NHI).", "chr_id": "3", "chr_pos": "9928479", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T336", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 12, "direction": "downstream", "id": "Q8NAC3-1.324.324", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 11, "direction": "downstream", "id": "Q8NAC3-1.325.325", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q8NAC3-1.334.334", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.367.367", "start_pos": 367, "end_pos": 367, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q8NAC3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8NAC3", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "A", "start_aa": "A", "up_seq": "WPLEPDSVRTNICPFREDPR", "down_seq": "HQNLWQAARLQLLTLQSWLL", "snv": [ { "evidence": [ { "id": "Q8NAC3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8NAC3" } ], "glycoeffect": [], "subjects_tested": "1773", "subjects_positive": "2", "frequency": "0.1", "sequence_org": "A", "sequence_mut": "T", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "3", "chr_pos": "9928313", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "A367", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ], "unlinked_id_list": [ "DOID:4203", "DOID:3541", "DOID:4706", "DOID:1659", "DOID:368" ], "evidence": [ { "id": "1319", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1319" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 5, "direction": "upstream", "id": "Q8NAC3-1.372.372", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.372.372", "start_pos": 372, "end_pos": 372, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1559311879", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1559311879", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1559311879", "url": "https://www.ensembl.org/id/rs1559311879", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "W", "start_aa": "W", "up_seq": "DSVRTNICPFREDPRAHQNL", "down_seq": "QAARLQLLTLQSWLLDAPCS", "snv": [ { "evidence": [ { "id": "rs1559311879", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1559311879" }, { "id": "rs1559311879", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1559311879" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "W", "sequence_mut": "S", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (NLW->NLS).", "chr_id": "3", "chr_pos": "9928329", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "W372", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 5, "direction": "downstream", "id": "Q8NAC3-1.367.367", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.422.422", "start_pos": 422, "end_pos": 422, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs568856493", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs568856493", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs568856493", "url": "https://www.ncbi.nlm.nih.gov/snp/rs568856493#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "RAPGGDPCQPLVPPLSWENV", "down_seq": "VDKVLEFPLLKGHPNLCVQV", "snv": [ { "evidence": [ { "id": "rs568856493", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs568856493" }, { "id": "rs568856493", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs568856493#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NVT->NVI).", "chr_id": "3", "chr_pos": "9928479", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T422", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "downstream", "id": "Q8NAC3-1.420.420", "categories": [ "glycosylation_flag" ] }, { "distance": 5, "direction": "upstream", "id": "Q8NAC3-1.427.427", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.427.427", "start_pos": 427, "end_pos": 427, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q8NAC3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8NAC3", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "L", "start_aa": "L", "up_seq": "DPCQPLVPPLSWENVTVDKV", "down_seq": "EFPLLKGHPNLCVQVNSSEK", "snv": [ { "evidence": [ { "id": "Q8NAC3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8NAC3" } ], "glycoeffect": [], "subjects_tested": "1704", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "L", "sequence_mut": "I", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "3", "chr_pos": "9928586", "ref_nt": "C", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "L427", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 7, "direction": "downstream", "id": "Q8NAC3-1.420.420", "categories": [ "glycosylation_flag" ] }, { "distance": 5, "direction": "downstream", "id": "Q8NAC3-1.422.422", "categories": [ "snv_flag" ] }, { "distance": 16, "direction": "upstream", "id": "Q8NAC3-1.443.443", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 18, "direction": "upstream", "id": "Q8NAC3-1.445.445", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.445.445", "start_pos": 445, "end_pos": 445, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q8NAC3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8NAC3", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs140836340", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs140836340", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs140836340", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs140836340", "database": "1000Genomes", "categories": [ "Other" ] }, { "id": "rs140836340", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs140836340", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs140836340", "url": "https://www.ncbi.nlm.nih.gov/snp/rs140836340#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs140836340", "url": "http://gnomad.broadinstitute.org/awesome?query=rs140836340", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "KVLEFPLLKGHPNLCVQVNS", "down_seq": "EKLQLQECLWADSLGPLKDD", "snv": [ { "evidence": [ { "id": "Q8NAC3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8NAC3" }, { "id": "rs140836340", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs140836340" }, { "id": "rs140836340", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs140836340" }, { "id": "rs140836340", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs140836340" }, { "id": "rs140836340", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs140836340#frequency_tab" }, { "id": "rs140836340", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs140836340" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "subjects_tested": "3601", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "L", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-loss (NSS->NSL).", "chr_id": "3", "chr_pos": "9929862", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "S445", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] }, { "disease_id": "DOID:2058", "recommended_name": { "id": "DOID:2058", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2058", "name": "chronic mucocutaneous candidiasis", "description": "A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp." }, "synonyms": [ { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "CANDF1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1, autosomal dominant", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "predisposition to invasive fungal disease due to CARD9 deficiency", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, 2, autosomal recessive", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, type 2", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "invasive candidiasis-deep dermatophytosis syndrome", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "CANDF2", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "CARD9 deficiency", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis familial chronic mucocutaneous, autosomal recessive", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, 2", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "candidiasis, familial, 3", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "CANDF3", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "candidiasis, familial, 3", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4", "description": "Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the CLEC7A gene." }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "CLEC7A familial chronic mucocutaneous candidiasis", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4, autosomal recessive", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, type 4", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "familial chronic mucocutaneous candidiasis caused by mutation in CLEC7A", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "CANDF4", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6", "description": "Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17F gene." }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "IL17F familial chronic mucocutaneous candidiasis", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6, autosomal dominant", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, type 6", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "familial chronic mucocutaneous candidiasis caused by mutation in IL17F", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "CANDF6", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, 8", "description": "Any chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the TRAF3IP2 gene." }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "TRAF3IP2 chronic mucocutaneous candidiasis (disease)", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, 8", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, type 8", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "chronic mucocutaneous candidiasis (disease) caused by mutation in TRAF3IP2", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "CANDF8", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, 9", "description": "Any chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17RC gene." }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "IL17RC chronic mucocutaneous candidiasis (disease)", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, 9", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, type 9", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "chronic mucocutaneous candidiasis (disease) caused by mutation in IL17RC", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "CANDF9", "description": "" }, { "id": "MIM:212050", "resource": "MIM", "url": "https://www.omim.org/entry/212050", "name": "Immunodeficiency 103, susceptibility to fungal infections", "description": "Immunodeficiency 103, susceptibility to fungal infections" }, { "id": "MIM:613108", "resource": "MIM", "url": "https://www.omim.org/entry/613108", "name": "Candidiasis, familial, 4", "description": "Candidiasis, familial, 4" }, { "id": "MIM:613956", "resource": "MIM", "url": "https://www.omim.org/entry/613956", "name": "Candidiasis, familial, 6", "description": "Candidiasis, familial, 6" }, { "id": "MIM:615527", "resource": "MIM", "url": "https://www.omim.org/entry/615527", "name": "Candidiasis, familial, 8", "description": "Candidiasis, familial, 8" }, { "id": "MIM:616445", "resource": "MIM", "url": "https://www.omim.org/entry/616445", "name": "Candidiasis, familial, 9", "description": "Candidiasis, familial, 9" } ], "unlinked_id_list": [], "evidence": [ { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" }, { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" }, { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 18, "direction": "downstream", "id": "Q8NAC3-1.427.427", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q8NAC3-1.443.443", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.486.486", "start_pos": 486, "end_pos": 486, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs2084513820", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2084513820", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs2084513820", "url": "https://www.ensembl.org/id/rs2084513820", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "VLLLETRGPQDNRSLCALEP", "down_seq": "GCTSLPSKASTRAARLGEYL", "snv": [ { "evidence": [ { "id": "rs2084513820", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2084513820" }, { "id": "rs2084513820", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs2084513820" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (SGC->NGC).", "chr_id": "3", "chr_pos": "9930115", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S486", "disease": [ { "disease_id": "DOID:2058", "recommended_name": { "id": "DOID:2058", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2058", "name": "chronic mucocutaneous candidiasis", "description": "A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp." }, "synonyms": [ { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "CANDF1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1, autosomal dominant", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "predisposition to invasive fungal disease due to CARD9 deficiency", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, 2, autosomal recessive", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, type 2", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "invasive candidiasis-deep dermatophytosis syndrome", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "CANDF2", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "CARD9 deficiency", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis familial chronic mucocutaneous, autosomal recessive", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, 2", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "candidiasis, familial, 3", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "CANDF3", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "candidiasis, familial, 3", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4", "description": "Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the CLEC7A gene." }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "CLEC7A familial chronic mucocutaneous candidiasis", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4, autosomal recessive", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, type 4", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "familial chronic mucocutaneous candidiasis caused by mutation in CLEC7A", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "CANDF4", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6", "description": "Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17F gene." }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "IL17F familial chronic mucocutaneous candidiasis", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6, autosomal dominant", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, type 6", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "familial chronic mucocutaneous candidiasis caused by mutation in IL17F", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "CANDF6", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, 8", "description": "Any chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the TRAF3IP2 gene." }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "TRAF3IP2 chronic mucocutaneous candidiasis (disease)", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, 8", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, type 8", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "chronic mucocutaneous candidiasis (disease) caused by mutation in TRAF3IP2", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "CANDF8", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, 9", "description": "Any chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17RC gene." }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "IL17RC chronic mucocutaneous candidiasis (disease)", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, 9", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, type 9", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "chronic mucocutaneous candidiasis (disease) caused by mutation in IL17RC", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "CANDF9", "description": "" }, { "id": "MIM:212050", "resource": "MIM", "url": "https://www.omim.org/entry/212050", "name": "Immunodeficiency 103, susceptibility to fungal infections", "description": "Immunodeficiency 103, susceptibility to fungal infections" }, { "id": "MIM:613108", "resource": "MIM", "url": "https://www.omim.org/entry/613108", "name": "Candidiasis, familial, 4", "description": "Candidiasis, familial, 4" }, { "id": "MIM:613956", "resource": "MIM", "url": "https://www.omim.org/entry/613956", "name": "Candidiasis, familial, 6", "description": "Candidiasis, familial, 6" }, { "id": "MIM:615527", "resource": "MIM", "url": "https://www.omim.org/entry/615527", "name": "Candidiasis, familial, 8", "description": "Candidiasis, familial, 8" }, { "id": "MIM:616445", "resource": "MIM", "url": "https://www.omim.org/entry/616445", "name": "Candidiasis, familial, 9", "description": "Candidiasis, familial, 9" } ], "unlinked_id_list": [], "evidence": [ { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" }, { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" }, { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" } ] } ], "keywords": [ "ebi", "germline", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 9, "direction": "downstream", "id": "Q8NAC3-1.477.477", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.56.56", "start_pos": 56, "end_pos": 56, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q8NAC3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8NAC3", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs75116348", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs75116348", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs75116348", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs75116348", "database": "1000Genomes", "categories": [ "Other" ] }, { "id": "rs75116348", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs75116348", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs75116348", "url": "https://www.ncbi.nlm.nih.gov/snp/rs75116348#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs75116348", "url": "http://gnomad.broadinstitute.org/awesome?query=rs75116348", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "VSLEPWGDEERLRVQFLAQQ", "down_seq": "LSLAPVTAATARTALSGLSG", "snv": [ { "evidence": [ { "id": "Q8NAC3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8NAC3" }, { "id": "rs75116348", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs75116348" }, { "id": "rs75116348", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs75116348" }, { "id": "rs75116348", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs75116348" }, { "id": "rs75116348", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs75116348#frequency_tab" }, { "id": "rs75116348", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs75116348" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "subjects_tested": "9251", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "N", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (SLS->NLS).", "chr_id": "3", "chr_pos": "9917482", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "S56", "disease": [ { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematological tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "blood cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:0081452", "DOID:706", "DOID:1039", "DOID:5604", "DOID:6536", "DOID:0080638", "DOID:7757", "DOID:0050743", "DOID:4960", "DOID:8527", "DOID:1036", "DOID:5772" ], "evidence": [ { "id": "2531", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2531" } ] }, { "disease_id": "DOID:2058", "recommended_name": { "id": "DOID:2058", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2058", "name": "chronic mucocutaneous candidiasis", "description": "A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp." }, "synonyms": [ { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "CANDF1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1, autosomal dominant", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "predisposition to invasive fungal disease due to CARD9 deficiency", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, 2, autosomal recessive", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, type 2", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "invasive candidiasis-deep dermatophytosis syndrome", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "CANDF2", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "CARD9 deficiency", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis familial chronic mucocutaneous, autosomal recessive", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, 2", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "candidiasis, familial, 3", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "CANDF3", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "candidiasis, familial, 3", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4", "description": "Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the CLEC7A gene." }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "CLEC7A familial chronic mucocutaneous candidiasis", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4, autosomal recessive", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, type 4", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "familial chronic mucocutaneous candidiasis caused by mutation in CLEC7A", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "CANDF4", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6", "description": "Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17F gene." }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "IL17F familial chronic mucocutaneous candidiasis", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6, autosomal dominant", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, type 6", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "familial chronic mucocutaneous candidiasis caused by mutation in IL17F", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "CANDF6", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, 8", "description": "Any chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the TRAF3IP2 gene." }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "TRAF3IP2 chronic mucocutaneous candidiasis (disease)", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, 8", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, type 8", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "chronic mucocutaneous candidiasis (disease) caused by mutation in TRAF3IP2", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "CANDF8", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, 9", "description": "Any chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17RC gene." }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "IL17RC chronic mucocutaneous candidiasis (disease)", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, 9", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, type 9", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "chronic mucocutaneous candidiasis (disease) caused by mutation in IL17RC", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "CANDF9", "description": "" }, { "id": "MIM:212050", "resource": "MIM", "url": "https://www.omim.org/entry/212050", "name": "Immunodeficiency 103, susceptibility to fungal infections", "description": "Immunodeficiency 103, susceptibility to fungal infections" }, { "id": "MIM:613108", "resource": "MIM", "url": "https://www.omim.org/entry/613108", "name": "Candidiasis, familial, 4", "description": "Candidiasis, familial, 4" }, { "id": "MIM:613956", "resource": "MIM", "url": "https://www.omim.org/entry/613956", "name": "Candidiasis, familial, 6", "description": "Candidiasis, familial, 6" }, { "id": "MIM:615527", "resource": "MIM", "url": "https://www.omim.org/entry/615527", "name": "Candidiasis, familial, 8", "description": "Candidiasis, familial, 8" }, { "id": "MIM:616445", "resource": "MIM", "url": "https://www.omim.org/entry/616445", "name": "Candidiasis, familial, 9", "description": "Candidiasis, familial, 9" } ], "unlinked_id_list": [], "evidence": [ { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" }, { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" }, { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q8NAC3-1.789.789", "start_pos": 789, "end_pos": 789, "uniprot_canonical_ac": "Q8NAC3-1", "length": 791, "uniprot_id": "I17RC_HUMAN", "protein_name": "Interleukin-17 receptor C", "refseq_ac": "NP_001190192", "refseq_name": "interleukin-17 receptor C isoform 4 precursor", "gene_name": "IL17RC", "gene_names_uniprotkb": "IL17RC; PRO38901", "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NAC3", "url": "https://www.uniprot.org/uniprotkb/Q8NAC3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q8NAC3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8NAC3", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs755919625", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755919625", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs755919625", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755919625", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs755919625", "url": "https://www.ncbi.nlm.nih.gov/snp/rs755919625#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs755919625", "url": "http://gnomad.broadinstitute.org/awesome?query=rs755919625", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "PPGTPAPGRGVGPGAGPGAG", "down_seq": "GT", "snv": [ { "evidence": [ { "id": "Q8NAC3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q8NAC3" }, { "id": "rs755919625", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755919625" }, { "id": "rs755919625", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755919625" }, { "id": "rs755919625", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs755919625#frequency_tab" }, { "id": "rs755919625", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs755919625" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "subjects_tested": "4799", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (DGT->NGT).", "chr_id": "3", "chr_pos": "9933582", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "D789", "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "unlinked_id_list": [ "DOID:4765" ], "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] }, { "disease_id": "DOID:2058", "recommended_name": { "id": "DOID:2058", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2058", "name": "chronic mucocutaneous candidiasis", "description": "A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp." }, "synonyms": [ { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "CANDF1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1", "description": "" }, { "id": "MONDO:0007257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007257", "name": "candidiasis, familial, 1, autosomal dominant", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "predisposition to invasive fungal disease due to CARD9 deficiency", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, 2, autosomal recessive", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, type 2", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "invasive candidiasis-deep dermatophytosis syndrome", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "CANDF2", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "CARD9 deficiency", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis familial chronic mucocutaneous, autosomal recessive", "description": "" }, { "id": "MONDO:0008905", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008905", "name": "candidiasis, familial, 2", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "candidiasis, familial, 3", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "CANDF3", "description": "" }, { "id": "MONDO:0011880", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011880", "name": "candidiasis, familial, 3", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4", "description": "Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the CLEC7A gene." }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "CLEC7A familial chronic mucocutaneous candidiasis", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, 4, autosomal recessive", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "candidiasis, familial, type 4", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "familial chronic mucocutaneous candidiasis caused by mutation in CLEC7A", "description": "" }, { "id": "MONDO:0013140", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013140", "name": "CANDF4", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6", "description": "Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17F gene." }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "IL17F familial chronic mucocutaneous candidiasis", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, 6, autosomal dominant", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "candidiasis, familial, type 6", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "familial chronic mucocutaneous candidiasis caused by mutation in IL17F", "description": "" }, { "id": "MONDO:0013503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013503", "name": "CANDF6", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, 8", "description": "Any chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the TRAF3IP2 gene." }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "TRAF3IP2 chronic mucocutaneous candidiasis (disease)", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, 8", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "candidiasis, familial, type 8", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "chronic mucocutaneous candidiasis (disease) caused by mutation in TRAF3IP2", "description": "" }, { "id": "MONDO:0014230", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014230", "name": "CANDF8", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, 9", "description": "Any chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17RC gene." }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "IL17RC chronic mucocutaneous candidiasis (disease)", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, 9", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "candidiasis, familial, type 9", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "chronic mucocutaneous candidiasis (disease) caused by mutation in IL17RC", "description": "" }, { "id": "MONDO:0014642", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014642", "name": "CANDF9", "description": "" }, { "id": "MIM:212050", "resource": "MIM", "url": "https://www.omim.org/entry/212050", "name": "Immunodeficiency 103, susceptibility to fungal infections", "description": "Immunodeficiency 103, susceptibility to fungal infections" }, { "id": "MIM:613108", "resource": "MIM", "url": "https://www.omim.org/entry/613108", "name": "Candidiasis, familial, 4", "description": "Candidiasis, familial, 4" }, { "id": "MIM:613956", "resource": "MIM", "url": "https://www.omim.org/entry/613956", "name": "Candidiasis, familial, 6", "description": "Candidiasis, familial, 6" }, { "id": "MIM:615527", "resource": "MIM", "url": "https://www.omim.org/entry/615527", "name": "Candidiasis, familial, 8", "description": "Candidiasis, familial, 8" }, { "id": "MIM:616445", "resource": "MIM", "url": "https://www.omim.org/entry/616445", "name": "Candidiasis, familial, 9", "description": "Candidiasis, familial, 9" } ], "unlinked_id_list": [], "evidence": [ { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" }, { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" }, { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "189", "end_pos": "189" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "420", "end_pos": "420" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "477", "end_pos": "477" } ] }, { "type": "snv", "site_list": [ { "start_pos": "149", "end_pos": "149" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "152", "end_pos": "152" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "191", "end_pos": "191" }, { "start_pos": "207", "end_pos": "207" }, { "start_pos": "235", "end_pos": "235" }, { "start_pos": "243", "end_pos": "243" }, { "start_pos": "257", "end_pos": "257" }, { "start_pos": "259", "end_pos": "259" }, { "start_pos": "284", "end_pos": "284" }, { "start_pos": "285", "end_pos": "285" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "324", "end_pos": "324" }, { "start_pos": "325", "end_pos": "325" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "372", "end_pos": "372" }, { "start_pos": "422", "end_pos": "422" }, { "start_pos": "427", "end_pos": "427" }, { "start_pos": "443", "end_pos": "443" }, { "start_pos": "445", "end_pos": "445" }, { "start_pos": "486", "end_pos": "486" }, { "start_pos": "56", "end_pos": "56" }, { "start_pos": "789", "end_pos": "789" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q00613-1.123.123", "start_pos": 123, "end_pos": 123, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q00613", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q00613" }, { "database": "O-GlcNAc Atlas", "id": "Q00613", "url": "https://oglcnac.org/atlas/detail/Q00613" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Wang X, Khaleque MA, Zhao MJ, Zhong R, Gaestel M, Calderwood SK", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371453" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "16278218", "url": "https://glygen.org/publication/PubMed/16278218" } ] } ], "crossref": [ { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "https://oglcnac.org/atlas/detail/Q00613", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "16278218", "url": "https://glygen.org/publication/PubMed/16278218", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "CFLRGQEQLLENIKRKVTSV", "down_seq": "TLKSEDIKIRQDSVTKLLTD", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser123", "evidence": [ { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "Q00613", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q00613" } ] } ], "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "No effect on binding HSE nor on transcriptional activity.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "16278218", "url": "https://glygen.org/publication/PubMed/16278218" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "glycosylation_flag", "mutagenesis_flag" ], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 5, "direction": "downstream", "id": "Q00613-1.118.118", "categories": [ "mutagenesis_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q00613-1.120.120", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q00613-1.121.121", "categories": [ "mutagenesis_flag", "snv_flag", "phosphorylation_flag" ] }, { "distance": 1, "direction": "upstream", "id": "Q00613-1.124.124", "categories": [ "glycosylation_flag", "mutagenesis_flag", "snv_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q00613-1.126.126", "categories": [ "mutagenesis_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q00613-1.127.127", "categories": [ "phosphorylation_flag" ] }, { "distance": 17, "direction": "upstream", "id": "Q00613-1.140.140", "categories": [ "mutagenesis_flag" ] }, { "distance": 19, "direction": "upstream", "id": "Q00613-1.142.142", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.124.124", "start_pos": 124, "end_pos": 124, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q00613", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q00613" }, { "database": "O-GlcNAc Atlas", "id": "Q00613", "url": "https://oglcnac.org/atlas/detail/Q00613" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Wang X, Khaleque MA, Zhao MJ, Zhong R, Gaestel M, Calderwood SK", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371453" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "16278218", "url": "https://glygen.org/publication/PubMed/16278218" } ] } ], "crossref": [ { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "https://oglcnac.org/atlas/detail/Q00613", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "16278218", "url": "https://glygen.org/publication/PubMed/16278218", "database": "PubMed", "categories": [ "Other" ] }, { "id": "rs1588656782", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1588656782", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1588656782", "url": "https://www.ensembl.org/id/rs1588656782", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "FLRGQEQLLENIKRKVTSVS", "down_seq": "LKSEDIKIRQDSVTKLLTDV", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr124", "evidence": [ { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "Q00613", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q00613" } ] } ], "mutagenesis": [ { "sequence_org": "T", "sequence_mut": "A", "comment": "No effect on binding HSE nor on transcriptional activity.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "16278218", "url": "https://glygen.org/publication/PubMed/16278218" } ] } ], "snv": [ { "evidence": [ { "id": "rs1588656782", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1588656782" }, { "id": "rs1588656782", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1588656782" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "T", "sequence_mut": "P", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (T->P).", "chr_id": "8", "chr_pos": "144309778", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T124", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "glycosylation_flag", "mutagenesis_flag", "snv_flag" ], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 6, "direction": "downstream", "id": "Q00613-1.118.118", "categories": [ "mutagenesis_flag" ] }, { "distance": 4, "direction": "downstream", "id": "Q00613-1.120.120", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q00613-1.121.121", "categories": [ "mutagenesis_flag", "snv_flag", "phosphorylation_flag" ] }, { "distance": 1, "direction": "downstream", "id": "Q00613-1.123.123", "categories": [ "glycosylation_flag", "mutagenesis_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q00613-1.126.126", "categories": [ "mutagenesis_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q00613-1.127.127", "categories": [ "phosphorylation_flag" ] }, { "distance": 16, "direction": "upstream", "id": "Q00613-1.140.140", "categories": [ "mutagenesis_flag" ] }, { "distance": 18, "direction": "upstream", "id": "Q00613-1.142.142", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.214.214", "start_pos": 214, "end_pos": 214, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Deep quantitative glycoproteomics reveals gut microbiome induced remodeling of the brain glycoproteome", "journal": "bioRxiv", "date": "2023", "authors": "Potel C.M., Burtscher M.L., Garrido-Rodriguez M., Brauer-Nikonow A., Becher I., Typas A., Zimmermann M., Savitski M.", "evidence": [ { "database": "Data Submission", "id": "GLY_000888", "url": "http://data.glygen.org/GLY_000888" } ], "reference": [ { "type": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" } ] } ], "crossref": [ { "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529", "database": "DOI", "categories": [ "Other" ] }, { "id": "GLY_000888", "url": "http://data.glygen.org/GLY_000888", "database": "Data Submission", "categories": [ "Other" ] }, { "id": "Q00613", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q00613", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs1816658542", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1816658542", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1816658542", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1816658542#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs1816658542", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1816658542", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "ISLVQSNRILGVKRKIPLML", "down_seq": "DSGSAHSMPKYSRQFSLEHV", "glycosylation": [ { "glytoucan_ac": "G86339HP", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "IPLMLNDSGSAHSMPK", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn214", "evidence": [ { "id": "10.1101/2023.09.13.557529", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "id": "GLY_000888", "database": "Data Submission", "url": "http://data.glygen.org/GLY_000888" } ] } ], "snv": [ { "evidence": [ { "id": "Q00613", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q00613" }, { "id": "rs1816658542", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1816658542" }, { "id": "rs1816658542", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1816658542#frequency_tab" }, { "id": "rs1816658542", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1816658542" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "subjects_tested": "2053", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "N", "sequence_mut": "S", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-loss (NDS->SDS).", "chr_id": "8", "chr_pos": "144311519", "ref_nt": "A", "alt_nt": "G", "minor_allelic_frequency": "", "site_lbl": "N214", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 6, "direction": "downstream", "id": "Q00613-1.208.208", "categories": [ "mutagenesis_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q00613-1.216.216", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 16, "direction": "upstream", "id": "Q00613-1.230.230", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.0.0", "start_pos": 0, "end_pos": 0, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Hyper-O-GlcNAcylation inhibits the induction of heat shock protein 70 (Hsp 70) by sodium arsenite in HeLa cells.", "journal": "Biological & pharmaceutical bulletin", "date": "2014", "authors": "Miura Y, Sato T, Sakurai Y, Sakai R, Hiraoka W, Endo T", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q00613", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q00613" } ], "reference": [ { "type": "PubMed", "id": "25087952", "url": "https://glygen.org/publication/PubMed/25087952" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q00613", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q00613" }, { "database": "O-GlcNAc Atlas", "id": "Q00613", "url": "https://oglcnac.org/atlas/detail/Q00613" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q00613", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q00613" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] } ], "crossref": [ { "id": "25087952", "url": "https://glygen.org/publication/PubMed/25087952", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q00613", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "evidence": [ { "id": "25087952", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/25087952" }, { "id": "Q00613", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q00613" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 16, "direction": "upstream", "id": "Q00613-1.16.16", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.118.118", "start_pos": 118, "end_pos": 118, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Interplay of acetyltransferase EP300 and the proteasome system in regulating heat shock transcription factor 1.", "journal": "Cell", "date": "2014", "authors": "Raychaudhuri S, Loew C, Korner R, Pinkert S, Theis M, Hayer-Hartl M, Buchholz F, Hartl FU", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "reference": [ { "type": "PubMed", "id": "24581496", "url": "https://glygen.org/publication/PubMed/24581496" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "24581496", "url": "https://glygen.org/publication/PubMed/24581496", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "EFQHPCFLRGQEQLLENIKR", "down_seq": "VTSVSTLKSEDIKIRQDSVT", "mutagenesis": [ { "sequence_org": "K", "sequence_mut": "Q", "comment": "Loss of nuclear stress bodies localization. No change in protein abundance.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "24581496", "url": "https://glygen.org/publication/PubMed/24581496" } ] }, { "sequence_org": "K", "sequence_mut": "R", "comment": "No change in nuclear stress bodies localization.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "24581496", "url": "https://glygen.org/publication/PubMed/24581496" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "upstream", "id": "Q00613-1.120.120", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q00613-1.121.121", "categories": [ "mutagenesis_flag", "snv_flag", "phosphorylation_flag" ] }, { "distance": 5, "direction": "upstream", "id": "Q00613-1.123.123", "categories": [ "glycosylation_flag", "mutagenesis_flag" ] }, { "distance": 6, "direction": "upstream", "id": "Q00613-1.124.124", "categories": [ "glycosylation_flag", "mutagenesis_flag", "snv_flag" ] }, { "distance": 8, "direction": "upstream", "id": "Q00613-1.126.126", "categories": [ "mutagenesis_flag" ] }, { "distance": 9, "direction": "upstream", "id": "Q00613-1.127.127", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.120.120", "start_pos": 120, "end_pos": 120, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Wang X, Khaleque MA, Zhao MJ, Zhong R, Gaestel M, Calderwood SK", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371453" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "16278218", "url": "https://glygen.org/publication/PubMed/16278218" } ] }, { "title": "Phosphorylation of HSF1 by PIM2 Induces PD-L1 Expression and Promotes Tumor Growth in Breast Cancer.", "journal": "Cancer research", "date": "2019", "authors": "Yang T, Ren C, Lu C, Qiao P, Han X, Wang L, Wang D, Lv S, Sun Y, Yu Z", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "31409638", "url": "https://glygen.org/publication/PubMed/31409638" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "16278218", "url": "https://glygen.org/publication/PubMed/16278218", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "31409638", "url": "https://glygen.org/publication/PubMed/31409638", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QHPCFLRGQEQLLENIKRKV", "down_seq": "SVSTLKSEDIKIRQDSVTKL", "mutagenesis": [ { "sequence_org": "T", "sequence_mut": "A", "comment": "No effect on binding HSE nor on transcriptional activity.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "16278218", "url": "https://glygen.org/publication/PubMed/16278218" } ] } ], "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "31409638", "url": "https://glygen.org/publication/PubMed/31409638" } ], "site_lbl": "Thr120" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag", "phosphorylation_flag" ], "glycosylation": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "downstream", "id": "Q00613-1.118.118", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "upstream", "id": "Q00613-1.121.121", "categories": [ "mutagenesis_flag", "snv_flag", "phosphorylation_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q00613-1.123.123", "categories": [ "glycosylation_flag", "mutagenesis_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q00613-1.124.124", "categories": [ "glycosylation_flag", "mutagenesis_flag", "snv_flag" ] }, { "distance": 6, "direction": "upstream", "id": "Q00613-1.126.126", "categories": [ "mutagenesis_flag" ] }, { "distance": 7, "direction": "upstream", "id": "Q00613-1.127.127", "categories": [ "phosphorylation_flag" ] }, { "distance": 20, "direction": "upstream", "id": "Q00613-1.140.140", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.121.121", "start_pos": 121, "end_pos": 121, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Wang X, Khaleque MA, Zhao MJ, Zhong R, Gaestel M, Calderwood SK", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371453" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "16278218", "url": "https://glygen.org/publication/PubMed/16278218" } ] }, { "title": "IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.", "journal": "Scientific reports", "date": "2016", "authors": "Asano Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Tatebe S, Kitabayashi I, Tashiro F, Namiki H, Kondo T, Semba K, Aburatani H, Taya Y, Nakagama H, Ohki R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" } ] }, { "title": "Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress.", "journal": "BMC biochemistry", "date": "2005", "authors": "Guettouche T, Boellmann F, Lane WS, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371571", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371571" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" } ] }, { "title": "Oxidative stress impairs the heat stress response and delays unfolded protein recovery.", "journal": "PloS one", "date": "2009", "authors": "Adachi M, Liu Y, Fujii K, Calderwood SK, Nakai A, Imai K, Shinomura Y", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "19936221", "url": "https://glygen.org/publication/PubMed/19936221" } ] }, { "title": "Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK.", "journal": "The EMBO journal", "date": "2015", "authors": "Dai S, Tang Z, Cao J, Zhou W, Li H, Sampson S, Dai C", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "25425574", "url": "https://glygen.org/publication/PubMed/25425574" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "16278218", "url": "https://glygen.org/publication/PubMed/16278218", "database": "PubMed", "categories": [ "Other" ] }, { "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q00613", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs782740115", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs782740115", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs782740115", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs782740115", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs782740115", "url": "https://www.ncbi.nlm.nih.gov/snp/rs782740115#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs782740115", "url": "http://gnomad.broadinstitute.org/awesome?query=rs782740115", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "Q00613", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=Q00613", "database": "PRO", "categories": [ "Other" ] }, { "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19936221", "url": "https://glygen.org/publication/PubMed/19936221", "database": "PubMed", "categories": [ "Other" ] }, { "id": "25425574", "url": "https://glygen.org/publication/PubMed/25425574", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "HPCFLRGQEQLLENIKRKVT", "down_seq": "VSTLKSEDIKIRQDSVTKLL", "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "Increased binding HSE and transcriptional activity. Greatly reduced binding to HSP90AA1. No effect on MAPKAPK2 binding.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "16278218", "url": "https://glygen.org/publication/PubMed/16278218" } ] }, { "sequence_org": "S", "sequence_mut": "D", "comment": "Some inhibition of binding HSE and transcriptional activity. No change in binding HSP90AA1. Inhibits MAPKAPK2 binding. Decreased HSF1-induced expression of HSPA1A mRNA in a IER5-dependent manner; when associated with D-307; D-314; D-323 and D-367.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" }, { "database": "PubMed", "id": "16278218", "url": "https://glygen.org/publication/PubMed/16278218" } ] } ], "snv": [ { "evidence": [ { "id": "Q00613", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q00613" }, { "id": "rs782740115", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs782740115" }, { "id": "rs782740115", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs782740115" }, { "id": "rs782740115", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs782740115#frequency_tab" }, { "id": "rs782740115", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs782740115" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "subjects_tested": "2670", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "N", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (SVS->NVS).", "chr_id": "8", "chr_pos": "144309590", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "S121", "disease": [ { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ], "unlinked_id_list": [ "DOID:4203", "DOID:3541", "DOID:4706", "DOID:1659", "DOID:368" ], "evidence": [ { "id": "1319", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1319" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] } ], "phosphorylation": [ { "kinase_uniprot_canonical_ac": "P49137-1", "kinase_gene_name": "MAPKAPK2", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "16278218", "url": "https://glygen.org/publication/PubMed/16278218" } ], "site_lbl": "Ser121" }, { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by MAPKAPK2", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "16278218", "url": "https://glygen.org/publication/PubMed/16278218" }, { "database": "PRO", "id": "Q00613", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=Q00613" }, { "database": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" }, { "database": "PubMed", "id": "19936221", "url": "https://glygen.org/publication/PubMed/19936221" }, { "database": "PubMed", "id": "25425574", "url": "https://glygen.org/publication/PubMed/25425574" }, { "database": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" } ], "site_lbl": "Ser121" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag", "snv_flag", "phosphorylation_flag" ], "glycosylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 3, "direction": "downstream", "id": "Q00613-1.118.118", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "downstream", "id": "Q00613-1.120.120", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q00613-1.123.123", "categories": [ "glycosylation_flag", "mutagenesis_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q00613-1.124.124", "categories": [ "glycosylation_flag", "mutagenesis_flag", "snv_flag" ] }, { "distance": 5, "direction": "upstream", "id": "Q00613-1.126.126", "categories": [ "mutagenesis_flag" ] }, { "distance": 6, "direction": "upstream", "id": "Q00613-1.127.127", "categories": [ "phosphorylation_flag" ] }, { "distance": 19, "direction": "upstream", "id": "Q00613-1.140.140", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": true, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.126.126", "start_pos": 126, "end_pos": 126, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Hietakangas V, Ahlskog JK, Jakobsson AM, Hellesuo M, Sahlberg NM, Holmberg CI, Mikhailov A, Palvimo JJ, Pirkkala L, Sistonen L", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "RGQEQLLENIKRKVTSVSTL", "down_seq": "SEDIKIRQDSVTKLLTDVQL", "mutagenesis": [ { "sequence_org": "K", "sequence_mut": "R", "comment": "No effect on sumoylation.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 8, "direction": "downstream", "id": "Q00613-1.118.118", "categories": [ "mutagenesis_flag" ] }, { "distance": 6, "direction": "downstream", "id": "Q00613-1.120.120", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 5, "direction": "downstream", "id": "Q00613-1.121.121", "categories": [ "mutagenesis_flag", "snv_flag", "phosphorylation_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q00613-1.123.123", "categories": [ "glycosylation_flag", "mutagenesis_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q00613-1.124.124", "categories": [ "glycosylation_flag", "mutagenesis_flag", "snv_flag" ] }, { "distance": 1, "direction": "upstream", "id": "Q00613-1.127.127", "categories": [ "phosphorylation_flag" ] }, { "distance": 14, "direction": "upstream", "id": "Q00613-1.140.140", "categories": [ "mutagenesis_flag" ] }, { "distance": 16, "direction": "upstream", "id": "Q00613-1.142.142", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.140.140", "start_pos": 140, "end_pos": 140, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Multiple layers of regulation of human heat shock transcription factor 1.", "journal": "Molecular and cellular biology", "date": "1995", "authors": "Zuo J, Rungger D, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "reference": [ { "type": "PubMed", "id": "7623826", "url": "https://glygen.org/publication/PubMed/7623826" } ] }, { "title": "Activation of the DNA-binding ability of human heat shock transcription factor 1 may involve the transition from an intramolecular to an intermolecular triple-stranded coiled-coil structure.", "journal": "Molecular and cellular biology", "date": "1994", "authors": "Zuo J, Baler R, Dahl G, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "reference": [ { "type": "PubMed", "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "7623826", "url": "https://glygen.org/publication/PubMed/7623826", "database": "PubMed", "categories": [ "Other" ] }, { "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "L", "start_aa": "L", "up_seq": "TSVSTLKSEDIKIRQDSVTK", "down_seq": "LTDVQLMKGKQECMDSKLLA", "mutagenesis": [ { "sequence_org": "L", "sequence_mut": "K", "comment": "Leads to constitutive homotrimerization and DNA-binding activities at 20 degrees Celsius. Does not lead to constitutive transactivation activity at 20 degrees Celsius. Decreased DNA-binding activity at 37 degrees Celsius.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "7623826", "url": "https://glygen.org/publication/PubMed/7623826" }, { "database": "PubMed", "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 20, "direction": "downstream", "id": "Q00613-1.120.120", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 19, "direction": "downstream", "id": "Q00613-1.121.121", "categories": [ "mutagenesis_flag", "snv_flag", "phosphorylation_flag" ] }, { "distance": 17, "direction": "downstream", "id": "Q00613-1.123.123", "categories": [ "glycosylation_flag", "mutagenesis_flag" ] }, { "distance": 16, "direction": "downstream", "id": "Q00613-1.124.124", "categories": [ "glycosylation_flag", "mutagenesis_flag", "snv_flag" ] }, { "distance": 14, "direction": "downstream", "id": "Q00613-1.126.126", "categories": [ "mutagenesis_flag" ] }, { "distance": 13, "direction": "downstream", "id": "Q00613-1.127.127", "categories": [ "phosphorylation_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q00613-1.142.142", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 7, "direction": "upstream", "id": "Q00613-1.147.147", "categories": [ "mutagenesis_flag" ] }, { "distance": 10, "direction": "upstream", "id": "Q00613-1.150.150", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.142.142", "start_pos": 142, "end_pos": 142, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Transcriptional activity and DNA binding of heat shock factor-1 involve phosphorylation on threonine 142 by CK2.", "journal": "Biochemical and biophysical research communications", "date": "2003", "authors": "Soncin F, Zhang X, Chu B, Wang X, Asea A, Ann Stevenson M, Sacks DB, Calderwood SK", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "12659875", "url": "https://glygen.org/publication/PubMed/12659875" } ] }, { "title": "ROS stress resets circadian clocks to coordinate pro-survival signals.", "journal": "PloS one", "date": "2013", "authors": "Tamaru T, Hattori M, Ninomiya Y, Kawamura G, Vares G, Honda K, Mishra DP, Wang B, Benjamin I, Sassone-Corsi P, Ozawa T, Takamatsu K", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "24312621", "url": "https://glygen.org/publication/PubMed/24312621" } ] }, { "title": "AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation.", "journal": "The FEBS journal", "date": "2022-07", "authors": "Lu Wen-Cheng, Omari Ramsey, Ray Haimanti, Wang John, Williams Imade, Jacobs Curteisha, Hockaden Natasha, Bochman Matthew L, Carpenter Richard L", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "35080342", "url": "https://glygen.org/publication/PubMed/35080342" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "12659875", "url": "https://glygen.org/publication/PubMed/12659875", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "24312621", "url": "https://glygen.org/publication/PubMed/24312621", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35080342", "url": "https://glygen.org/publication/PubMed/35080342", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "VSTLKSEDIKIRQDSVTKLL", "down_seq": "DVQLMKGKQECMDSKLLAMK", "mutagenesis": [ { "sequence_org": "T", "sequence_mut": "A", "comment": "Reduced promoter activity by about 90%. Almost no transcriptional activity when coexpressed with CK2.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "12659875", "url": "https://glygen.org/publication/PubMed/12659875" } ] } ], "phosphorylation": [ { "kinase_uniprot_canonical_ac": "P19784-1", "kinase_gene_name": "CSNK2A2", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "12659875", "url": "https://glygen.org/publication/PubMed/12659875" } ], "site_lbl": "Thr142" }, { "kinase_uniprot_canonical_ac": "P68400-1", "kinase_gene_name": "CSNK2A1", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "12659875", "url": "https://glygen.org/publication/PubMed/12659875" } ], "site_lbl": "Thr142" }, { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine; by CK2", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "12659875", "url": "https://glygen.org/publication/PubMed/12659875" }, { "database": "PubMed", "id": "24312621", "url": "https://glygen.org/publication/PubMed/24312621" }, { "database": "PubMed", "id": "35080342", "url": "https://glygen.org/publication/PubMed/35080342" } ], "site_lbl": "Thr142" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag", "phosphorylation_flag" ], "glycosylation": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "Q00613-1.123.123", "categories": [ "glycosylation_flag", "mutagenesis_flag" ] }, { "distance": 18, "direction": "downstream", "id": "Q00613-1.124.124", "categories": [ "glycosylation_flag", "mutagenesis_flag", "snv_flag" ] }, { "distance": 16, "direction": "downstream", "id": "Q00613-1.126.126", "categories": [ "mutagenesis_flag" ] }, { "distance": 15, "direction": "downstream", "id": "Q00613-1.127.127", "categories": [ "phosphorylation_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q00613-1.140.140", "categories": [ "mutagenesis_flag" ] }, { "distance": 5, "direction": "upstream", "id": "Q00613-1.147.147", "categories": [ "mutagenesis_flag" ] }, { "distance": 8, "direction": "upstream", "id": "Q00613-1.150.150", "categories": [ "mutagenesis_flag" ] }, { "distance": 20, "direction": "upstream", "id": "Q00613-1.162.162", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.147.147", "start_pos": 147, "end_pos": 147, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Multiple layers of regulation of human heat shock transcription factor 1.", "journal": "Molecular and cellular biology", "date": "1995", "authors": "Zuo J, Rungger D, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "reference": [ { "type": "PubMed", "id": "7623826", "url": "https://glygen.org/publication/PubMed/7623826" } ] }, { "title": "Activation of the DNA-binding ability of human heat shock transcription factor 1 may involve the transition from an intramolecular to an intermolecular triple-stranded coiled-coil structure.", "journal": "Molecular and cellular biology", "date": "1994", "authors": "Zuo J, Baler R, Dahl G, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "reference": [ { "type": "PubMed", "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "7623826", "url": "https://glygen.org/publication/PubMed/7623826", "database": "PubMed", "categories": [ "Other" ] }, { "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "M", "start_aa": "M", "up_seq": "SEDIKIRQDSVTKLLTDVQL", "down_seq": "KGKQECMDSKLLAMKHENEA", "mutagenesis": [ { "sequence_org": "M", "sequence_mut": "A", "comment": "Leads to constitutive homotrimerization and DNA-binding activities at 20 degrees Celsius. Does not lead to constitutive transactivation activity at 20 degrees Celsius. No effect on DNA-binding activity at 37 degrees Celsius.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "7623826", "url": "https://glygen.org/publication/PubMed/7623826" }, { "database": "PubMed", "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471" } ] }, { "sequence_org": "M", "sequence_mut": "E", "comment": "Does not lead to constitutive homotrimerization and DNA-binding activities at 20 degrees Celsius. Loss of DNA-binding activity at 37 degrees Celsius.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471" } ] }, { "sequence_org": "M", "sequence_mut": "K", "comment": "Does not lead to constitutive homotrimerization and DNA-binding activities at 20 degrees Celsius. Loss of DNA-binding activity at 37 degrees Celsius.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 20, "direction": "downstream", "id": "Q00613-1.127.127", "categories": [ "phosphorylation_flag" ] }, { "distance": 7, "direction": "downstream", "id": "Q00613-1.140.140", "categories": [ "mutagenesis_flag" ] }, { "distance": 5, "direction": "downstream", "id": "Q00613-1.142.142", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q00613-1.150.150", "categories": [ "mutagenesis_flag" ] }, { "distance": 15, "direction": "upstream", "id": "Q00613-1.162.162", "categories": [ "mutagenesis_flag" ] }, { "distance": 20, "direction": "upstream", "id": "Q00613-1.167.167", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.150.150", "start_pos": 150, "end_pos": 150, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Hietakangas V, Ahlskog JK, Jakobsson AM, Hellesuo M, Sahlberg NM, Holmberg CI, Mikhailov A, Palvimo JJ, Pirkkala L, Sistonen L", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "IKIRQDSVTKLLTDVQLMKG", "down_seq": "QECMDSKLLAMKHENEALWR", "mutagenesis": [ { "sequence_org": "K", "sequence_mut": "R", "comment": "No effect on sumoylation.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 10, "direction": "downstream", "id": "Q00613-1.140.140", "categories": [ "mutagenesis_flag" ] }, { "distance": 8, "direction": "downstream", "id": "Q00613-1.142.142", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q00613-1.147.147", "categories": [ "mutagenesis_flag" ] }, { "distance": 12, "direction": "upstream", "id": "Q00613-1.162.162", "categories": [ "mutagenesis_flag" ] }, { "distance": 17, "direction": "upstream", "id": "Q00613-1.167.167", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.162.162", "start_pos": 162, "end_pos": 162, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Hietakangas V, Ahlskog JK, Jakobsson AM, Hellesuo M, Sahlberg NM, Holmberg CI, Mikhailov A, Palvimo JJ, Pirkkala L, Sistonen L", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "TDVQLMKGKQECMDSKLLAM", "down_seq": "HENEALWREVASLRQKHAQQ", "mutagenesis": [ { "sequence_org": "K", "sequence_mut": "R", "comment": "No effect on sumoylation.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 20, "direction": "downstream", "id": "Q00613-1.142.142", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 15, "direction": "downstream", "id": "Q00613-1.147.147", "categories": [ "mutagenesis_flag" ] }, { "distance": 12, "direction": "downstream", "id": "Q00613-1.150.150", "categories": [ "mutagenesis_flag" ] }, { "distance": 5, "direction": "upstream", "id": "Q00613-1.167.167", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.189.189", "start_pos": 189, "end_pos": 189, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Activation of the DNA-binding ability of human heat shock transcription factor 1 may involve the transition from an intramolecular to an intermolecular triple-stranded coiled-coil structure.", "journal": "Molecular and cellular biology", "date": "1994", "authors": "Zuo J, Baler R, Dahl G, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "reference": [ { "type": "PubMed", "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471" } ] }, { "title": "Multiple layers of regulation of human heat shock transcription factor 1.", "journal": "Molecular and cellular biology", "date": "1995", "authors": "Zuo J, Rungger D, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "reference": [ { "type": "PubMed", "id": "7623826", "url": "https://glygen.org/publication/PubMed/7623826" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471", "database": "PubMed", "categories": [ "Other" ] }, { "id": "7623826", "url": "https://glygen.org/publication/PubMed/7623826", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "L", "start_aa": "L", "up_seq": "WREVASLRQKHAQQQKVVNK", "down_seq": "IQFLISLVQSNRILGVKRKI", "mutagenesis": [ { "sequence_org": "L", "sequence_mut": "A", "comment": "Does not lead to constitutive homotrimerization and DNA-binding activities at 20 degrees Celsius. Leads to constitutive homotrimerization and DNA-binding activities at 30 degrees Celsius. No effect on DNA-binding activity at 37 degrees Celsius.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471" } ] }, { "sequence_org": "L", "sequence_mut": "E", "comment": "Leads to constitutive homotrimerization, DNA-binding and transactivation activities at 20 degrees Celsius. Decreased DNA-binding activity at 37 degrees Celsius.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "7623826", "url": "https://glygen.org/publication/PubMed/7623826" }, { "database": "PubMed", "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471" } ] }, { "sequence_org": "L", "sequence_mut": "K", "comment": "Leads to constitutive homotrimerization and DNA-binding activities at 20 degrees Celsius. No effect on DNA-binding activity at 37 degrees Celsius.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 1, "direction": "upstream", "id": "Q00613-1.190.190", "categories": [ "snv_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q00613-1.193.193", "categories": [ "mutagenesis_flag" ] }, { "distance": 19, "direction": "upstream", "id": "Q00613-1.208.208", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.193.193", "start_pos": 193, "end_pos": 193, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Activation of the DNA-binding ability of human heat shock transcription factor 1 may involve the transition from an intramolecular to an intermolecular triple-stranded coiled-coil structure.", "journal": "Molecular and cellular biology", "date": "1994", "authors": "Zuo J, Baler R, Dahl G, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "reference": [ { "type": "PubMed", "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "L", "start_aa": "L", "up_seq": "ASLRQKHAQQQKVVNKLIQF", "down_seq": "ISLVQSNRILGVKRKIPLML", "mutagenesis": [ { "sequence_org": "L", "sequence_mut": "A", "comment": "Does not lead to constitutive homotrimerization and DNA-binding activities at 20 degrees Celsius. Leads to constitutive homotrimerization and DNA-binding activities at 30 degrees Celsius. No effect on DNA-binding activity at 37 degrees Celsius.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471" } ] }, { "sequence_org": "L", "sequence_mut": "E", "comment": "Leads to constitutive homotrimerization and DNA-binding activities at 20 degrees Celsius. Decreased DNA-binding activity at 37 degrees Celsius.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471" } ] }, { "sequence_org": "L", "sequence_mut": "K", "comment": "Leads to constitutive homotrimerization and DNA-binding activities at 20 degrees Celsius. Loss of DNA-binding activity at 37 degrees Celsius.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "downstream", "id": "Q00613-1.189.189", "categories": [ "mutagenesis_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q00613-1.190.190", "categories": [ "snv_flag" ] }, { "distance": 15, "direction": "upstream", "id": "Q00613-1.208.208", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.208.208", "start_pos": 208, "end_pos": 208, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Interplay of acetyltransferase EP300 and the proteasome system in regulating heat shock transcription factor 1.", "journal": "Cell", "date": "2014", "authors": "Raychaudhuri S, Loew C, Korner R, Pinkert S, Theis M, Hayer-Hartl M, Buchholz F, Hartl FU", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "reference": [ { "type": "PubMed", "id": "24581496", "url": "https://glygen.org/publication/PubMed/24581496" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "24581496", "url": "https://glygen.org/publication/PubMed/24581496", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "KLIQFLISLVQSNRILGVKR", "down_seq": "IPLMLNDSGSAHSMPKYSRQ", "mutagenesis": [ { "sequence_org": "K", "sequence_mut": "Q", "comment": "No change in nuclear stress bodies localization. Increased protein abundance.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "24581496", "url": "https://glygen.org/publication/PubMed/24581496" } ] }, { "sequence_org": "K", "sequence_mut": "R", "comment": "No change in nuclear stress bodies localization. No change in protein abundance.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "24581496", "url": "https://glygen.org/publication/PubMed/24581496" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "Q00613-1.189.189", "categories": [ "mutagenesis_flag" ] }, { "distance": 18, "direction": "downstream", "id": "Q00613-1.190.190", "categories": [ "snv_flag" ] }, { "distance": 15, "direction": "downstream", "id": "Q00613-1.193.193", "categories": [ "mutagenesis_flag" ] }, { "distance": 6, "direction": "upstream", "id": "Q00613-1.214.214", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 8, "direction": "upstream", "id": "Q00613-1.216.216", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.216.216", "start_pos": 216, "end_pos": 216, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Heat shock factor 1, an inhibitor of non-homologous end joining repair.", "journal": "Oncotarget", "date": "2015", "authors": "Kang GY, Kim EH, Lee HJ, Gil NY, Cha HJ, Lee YS", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "reference": [ { "type": "PubMed", "id": "26359349", "url": "https://glygen.org/publication/PubMed/26359349" } ] }, { "title": "HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression.", "journal": "Cancer research", "date": "2008", "authors": "Lee YJ, Kim EH, Lee JS, Jeoung D, Bae S, Kwon SH, Lee YS", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "18794143", "url": "https://glygen.org/publication/PubMed/18794143" } ] }, { "title": "Heat shock factor 1-mediated aneuploidy requires a defective function of p53.", "journal": "Cancer research", "date": "2009", "authors": "Kim EH, Lee YJ, Bae S, Lee JS, Kim J, Lee YS", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "19934326", "url": "https://glygen.org/publication/PubMed/19934326" } ] }, { "title": "Decreased expression of FBXW7 by ERK1/2 activation in drug-resistant cancer cells confers transcriptional activation of MDR1 by suppression of ubiquitin degradation of HSF1.", "journal": "Cell death & disease", "date": "2020", "authors": "Mun GI, Choi E, Lee Y, Lee YS", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "32457290", "url": "https://glygen.org/publication/PubMed/32457290" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "26359349", "url": "https://glygen.org/publication/PubMed/26359349", "database": "PubMed", "categories": [ "Other" ] }, { "id": "18794143", "url": "https://glygen.org/publication/PubMed/18794143", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "19934326", "url": "https://glygen.org/publication/PubMed/19934326", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32457290", "url": "https://glygen.org/publication/PubMed/32457290", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "LVQSNRILGVKRKIPLMLND", "down_seq": "GSAHSMPKYSRQFSLEHVHG", "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "Does not change interaction with XRCC5 and XRCC6. No PLK1-induced phosphorylation in mitosis. Inhibits PLK1-stimulated ubiquitinylation. Increased protein stability.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "26359349", "url": "https://glygen.org/publication/PubMed/26359349" }, { "database": "PubMed", "id": "18794143", "url": "https://glygen.org/publication/PubMed/18794143" } ] }, { "sequence_org": "S", "sequence_mut": "E", "comment": "Does not change interaction with XRCC5 and XRCC6. No change in spindle pole localization. Increases weakly PLK1-stimulated ubiquitinylation. No change in protein stability. Increased interaction with BTRC.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "26359349", "url": "https://glygen.org/publication/PubMed/26359349" }, { "database": "PubMed", "id": "18794143", "url": "https://glygen.org/publication/PubMed/18794143" } ] }, { "sequence_org": "S", "sequence_mut": "N", "comment": "Decreased spindle pole localization. Decreased interaction with BTRC. Increased protein stability.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "18794143", "url": "https://glygen.org/publication/PubMed/18794143" } ] } ], "phosphorylation": [ { "kinase_uniprot_canonical_ac": "P53350-1", "kinase_gene_name": "PLK1", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "18794143", "url": "https://glygen.org/publication/PubMed/18794143" } ], "site_lbl": "Ser216" }, { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PLK1", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "18794143", "url": "https://glygen.org/publication/PubMed/18794143" }, { "database": "PubMed", "id": "19934326", "url": "https://glygen.org/publication/PubMed/19934326" }, { "database": "PubMed", "id": "32457290", "url": "https://glygen.org/publication/PubMed/32457290" } ], "site_lbl": "Ser216" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag", "phosphorylation_flag" ], "glycosylation": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 8, "direction": "downstream", "id": "Q00613-1.208.208", "categories": [ "mutagenesis_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q00613-1.214.214", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 14, "direction": "upstream", "id": "Q00613-1.230.230", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.22.22", "start_pos": 22, "end_pos": 22, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Heat shock factor 1 represses Ras-induced transcriptional activation of the c-fos gene.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Chen C, Xie Y, Stevenson MA, Auron PE, Calderwood SK", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "reference": [ { "type": "PubMed", "id": "9341107", "url": "https://glygen.org/publication/PubMed/9341107" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "9341107", "url": "https://glygen.org/publication/PubMed/9341107", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "L", "start_aa": "L", "up_seq": "DLPVGPGAAGPSNVPAFLTK", "down_seq": "WTLVSDPDTDALICWSPSGN", "mutagenesis": [ { "sequence_org": "L", "sequence_mut": "A", "comment": "Inhibits HSEDNA-binding activity and transcriptional activation.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "9341107", "url": "https://glygen.org/publication/PubMed/9341107" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 6, "direction": "downstream", "id": "Q00613-1.16.16", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.230.230", "start_pos": 230, "end_pos": 230, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1.", "journal": "The EMBO journal", "date": "2001", "authors": "Holmberg CI, Hietakangas V, Mikhailov A, Rantanen JO, Kallio M, Meinander A, Hellman J, Morrice N, MacKintosh C, Morimoto RI, Eriksson JE, Sistonen L", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371571", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371571" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "11447121", "url": "https://glygen.org/publication/PubMed/11447121" } ] }, { "title": "Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Hietakangas V, Ahlskog JK, Jakobsson AM, Hellesuo M, Sahlberg NM, Holmberg CI, Mikhailov A, Palvimo JJ, Pirkkala L, Sistonen L", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" } ] }, { "title": "HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression.", "journal": "Cancer research", "date": "2008", "authors": "Lee YJ, Kim EH, Lee JS, Jeoung D, Bae S, Kwon SH, Lee YS", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "18794143", "url": "https://glygen.org/publication/PubMed/18794143" } ] }, { "title": "Cardioprotection by CaMKII-deltaB is mediated by phosphorylation of heat shock factor 1 and subsequent expression of inducible heat shock protein 70.", "journal": "Circulation research", "date": "2010", "authors": "Peng W, Zhang Y, Zheng M, Cheng H, Zhu W, Cao CM, Xiao RP", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "19910575", "url": "https://glygen.org/publication/PubMed/19910575" } ] }, { "title": "Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress.", "journal": "BMC biochemistry", "date": "2005", "authors": "Guettouche T, Boellmann F, Lane WS, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371571", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371571" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" } ] }, { "title": "Regulation of heat shock protein 60 and 72 expression in the failing heart.", "journal": "Journal of molecular and cellular cardiology", "date": "2010", "authors": "Wang Y, Chen L, Hagiwara N, Knowlton AA", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "19945465", "url": "https://glygen.org/publication/PubMed/19945465" } ] }, { "title": "RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy.", "journal": "Autophagy", "date": "2015", "authors": "Luan Q, Jin L, Jiang CC, Tay KH, Lai F, Liu XY, Liu YL, Guo ST, Li CY, Yan XG, Tseng HY, Zhang XD", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "26018731", "url": "https://glygen.org/publication/PubMed/26018731" } ] }, { "title": "IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.", "journal": "Scientific reports", "date": "2016", "authors": "Asano Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Tatebe S, Kitabayashi I, Tashiro F, Namiki H, Kondo T, Semba K, Aburatani H, Taya Y, Nakagama H, Ohki R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" } ] }, { "title": "Phosphorylation of HSF1 at serine 326 residue is related to the maintenance of gynecologic cancer stem cells through expression of HSP27.", "journal": "Oncotarget", "date": "2017", "authors": "Yasuda K, Hirohashi Y, Mariya T, Murai A, Tabuchi Y, Kuroda T, Kusumoto H, Takaya A, Yamamoto E, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Tamura Y, Hirano H, Hasegawa T, Saito T, Sato N, Torigoe T", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "28415561", "url": "https://glygen.org/publication/PubMed/28415561" } ] }, { "title": "Decreased expression of FBXW7 by ERK1/2 activation in drug-resistant cancer cells confers transcriptional activation of MDR1 by suppression of ubiquitin degradation of HSF1.", "journal": "Cell death & disease", "date": "2020", "authors": "Mun GI, Choi E, Lee Y, Lee YS", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "32457290", "url": "https://glygen.org/publication/PubMed/32457290" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "11447121", "url": "https://glygen.org/publication/PubMed/11447121", "database": "PubMed", "categories": [ "Other" ] }, { "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592", "database": "PubMed", "categories": [ "Other" ] }, { "id": "18794143", "url": "https://glygen.org/publication/PubMed/18794143", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "19910575", "url": "https://glygen.org/publication/PubMed/19910575", "database": "PubMed", "categories": [ "Other" ] }, { "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19945465", "url": "https://glygen.org/publication/PubMed/19945465", "database": "PubMed", "categories": [ "Other" ] }, { "id": "26018731", "url": "https://glygen.org/publication/PubMed/26018731", "database": "PubMed", "categories": [ "Other" ] }, { "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28415561", "url": "https://glygen.org/publication/PubMed/28415561", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32457290", "url": "https://glygen.org/publication/PubMed/32457290", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "PLMLNDSGSAHSMPKYSRQF", "down_seq": "LEHVHGSGPYSAPSPAYSSS", "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "No phosphorylation. No change in PLK1-induced phosphorylation in mitosis. No change in DNA-binding activity upon heat shock. Decreased transcriptional activity upon heat shock.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "11447121", "url": "https://glygen.org/publication/PubMed/11447121" }, { "database": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" }, { "database": "PubMed", "id": "18794143", "url": "https://glygen.org/publication/PubMed/18794143" } ] }, { "sequence_org": "S", "sequence_mut": "D", "comment": "Mimics phosphorylation. No effect on transcriptional activity upon heat shock.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "11447121", "url": "https://glygen.org/publication/PubMed/11447121" }, { "database": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" } ] } ], "phosphorylation": [ { "kinase_uniprot_canonical_ac": "Q13557-1", "kinase_gene_name": "CAMK2D", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "19910575", "url": "https://glygen.org/publication/PubMed/19910575" } ], "site_lbl": "Ser230" }, { "kinase_uniprot_canonical_ac": "Q9UQM7-1", "kinase_gene_name": "CAMK2A", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "11447121", "url": "https://glygen.org/publication/PubMed/11447121" } ], "site_lbl": "Ser230" }, { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by CAMK2A", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "11447121", "url": "https://glygen.org/publication/PubMed/11447121" }, { "database": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" }, { "database": "PubMed", "id": "19945465", "url": "https://glygen.org/publication/PubMed/19945465" }, { "database": "PubMed", "id": "26018731", "url": "https://glygen.org/publication/PubMed/26018731" }, { "database": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" }, { "database": "PubMed", "id": "28415561", "url": "https://glygen.org/publication/PubMed/28415561" }, { "database": "PubMed", "id": "32457290", "url": "https://glygen.org/publication/PubMed/32457290" } ], "site_lbl": "Ser230" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag", "phosphorylation_flag" ], "glycosylation": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 16, "direction": "downstream", "id": "Q00613-1.214.214", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 14, "direction": "downstream", "id": "Q00613-1.216.216", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 10 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.275.275", "start_pos": 275, "end_pos": 275, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Transcriptional activation of heat shock factor HSF1 probed by phosphopeptide analysis of factor 32P-labeled in vivo.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Xia W, Guo Y, Vilaboa N, Zuo J, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "9535852", "url": "https://glygen.org/publication/PubMed/9535852" } ] }, { "title": "Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Chu B, Soncin F, Price BD, Stevenson MA, Calderwood SK", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "8940068", "url": "https://glygen.org/publication/PubMed/8940068" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "9535852", "url": "https://glygen.org/publication/PubMed/9535852", "database": "PubMed", "categories": [ "Other" ] }, { "id": "8940068", "url": "https://glygen.org/publication/PubMed/8940068", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "PDAVASSGPIISDITELAPA", "down_seq": "PMASPGGSIDERPLSSSPLV", "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "Reduced increase in heat-induced transcriptional activity.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "9535852", "url": "https://glygen.org/publication/PubMed/9535852" } ] }, { "sequence_org": "S", "sequence_mut": "G", "comment": "Leads to weak constitutive transactivation activity at room temperature.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "8940068", "url": "https://glygen.org/publication/PubMed/8940068" } ] } ], "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "8940068", "url": "https://glygen.org/publication/PubMed/8940068" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "site_lbl": "Ser275" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag", "phosphorylation_flag" ], "glycosylation": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 8, "direction": "downstream", "id": "Q00613-1.267.267", "categories": [ "snv_flag" ] }, { "distance": 17, "direction": "upstream", "id": "Q00613-1.292.292", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.292.292", "start_pos": 292, "end_pos": 292, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Polo-like kinase 1 phosphorylates heat shock transcription factor 1 and mediates its nuclear translocation during heat stress.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Kim SA, Yoon JH, Lee SH, Ahn SG", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "15661742", "url": "https://glygen.org/publication/PubMed/15661742" } ] }, { "title": "Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress.", "journal": "BMC biochemistry", "date": "2005", "authors": "Guettouche T, Boellmann F, Lane WS, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371571", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371571" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" } ] }, { "title": "Phosphoproteomic analysis of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Brill LM, Xiong W, Lee KB, Ficarro SB, Crain A, Xu Y, Terskikh A, Snyder EY, Ding S", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "15661742", "url": "https://glygen.org/publication/PubMed/15661742", "database": "PubMed", "categories": [ "Other" ] }, { "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "APASPMASPGGSIDERPLSS", "down_seq": "PLVRVKEEPPSPPQSPRVEE", "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "Weak decreased PLK1-induced phosphorylation. Increased nuclear localization upon heat shock.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "15661742", "url": "https://glygen.org/publication/PubMed/15661742" } ] } ], "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" } ], "site_lbl": "Ser292" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag", "phosphorylation_flag" ], "glycosylation": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 17, "direction": "downstream", "id": "Q00613-1.275.275", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q00613-1.296.296", "categories": [ "mutagenesis_flag" ] }, { "distance": 5, "direction": "upstream", "id": "Q00613-1.297.297", "categories": [ "mutagenesis_flag" ] }, { "distance": 6, "direction": "upstream", "id": "Q00613-1.298.298", "categories": [ "mutagenesis_flag" ] }, { "distance": 7, "direction": "upstream", "id": "Q00613-1.299.299", "categories": [ "mutagenesis_flag" ] }, { "distance": 8, "direction": "upstream", "id": "Q00613-1.300.300", "categories": [ "mutagenesis_flag" ] }, { "distance": 11, "direction": "upstream", "id": "Q00613-1.303.303", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 15, "direction": "upstream", "id": "Q00613-1.307.307", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 17, "direction": "upstream", "id": "Q00613-1.309.309", "categories": [ "mutagenesis_flag" ] }, { "distance": 19, "direction": "upstream", "id": "Q00613-1.311.311", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.296.296", "start_pos": 296, "end_pos": 296, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Repression of human heat shock factor 1 activity at control temperature by phosphorylation.", "journal": "Genes & development", "date": "1996", "authors": "Knauf U, Newton EM, Kyriakis J, Kingston RE", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371453" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "PMASPGGSIDERPLSSSPLV", "down_seq": "VKEEPPSPPQSPRVEEASPG", "mutagenesis": [ { "sequence_org": "R", "sequence_mut": "A", "comment": "No effect neither on repression of transcriptional activity at control temperature nor on transcriptional activation upon heat shock.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "downstream", "id": "Q00613-1.292.292", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 1, "direction": "upstream", "id": "Q00613-1.297.297", "categories": [ "mutagenesis_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q00613-1.298.298", "categories": [ "mutagenesis_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q00613-1.299.299", "categories": [ "mutagenesis_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q00613-1.300.300", "categories": [ "mutagenesis_flag" ] }, { "distance": 7, "direction": "upstream", "id": "Q00613-1.303.303", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 11, "direction": "upstream", "id": "Q00613-1.307.307", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 13, "direction": "upstream", "id": "Q00613-1.309.309", "categories": [ "mutagenesis_flag" ] }, { "distance": 15, "direction": "upstream", "id": "Q00613-1.311.311", "categories": [ "mutagenesis_flag" ] }, { "distance": 18, "direction": "upstream", "id": "Q00613-1.314.314", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.297.297", "start_pos": 297, "end_pos": 297, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Repression of human heat shock factor 1 activity at control temperature by phosphorylation.", "journal": "Genes & development", "date": "1996", "authors": "Knauf U, Newton EM, Kyriakis J, Kingston RE", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371453" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "V", "start_aa": "V", "up_seq": "MASPGGSIDERPLSSSPLVR", "down_seq": "KEEPPSPPQSPRVEEASPGR", "mutagenesis": [ { "sequence_org": "V", "sequence_mut": "A", "comment": "Slight effect on derepression of transcriptional activity at control temperature and on transcriptional activation upon heat shock.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 5, "direction": "downstream", "id": "Q00613-1.292.292", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 1, "direction": "downstream", "id": "Q00613-1.296.296", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "upstream", "id": "Q00613-1.298.298", "categories": [ "mutagenesis_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q00613-1.299.299", "categories": [ "mutagenesis_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q00613-1.300.300", "categories": [ "mutagenesis_flag" ] }, { "distance": 6, "direction": "upstream", "id": "Q00613-1.303.303", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 10, "direction": "upstream", "id": "Q00613-1.307.307", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 12, "direction": "upstream", "id": "Q00613-1.309.309", "categories": [ "mutagenesis_flag" ] }, { "distance": 14, "direction": "upstream", "id": "Q00613-1.311.311", "categories": [ "mutagenesis_flag" ] }, { "distance": 17, "direction": "upstream", "id": "Q00613-1.314.314", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.298.298", "start_pos": 298, "end_pos": 298, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Hietakangas V, Ahlskog JK, Jakobsson AM, Hellesuo M, Sahlberg NM, Holmberg CI, Mikhailov A, Palvimo JJ, Pirkkala L, Sistonen L", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" } ] }, { "title": "Repression of human heat shock factor 1 activity at control temperature by phosphorylation.", "journal": "Genes & development", "date": "1996", "authors": "Knauf U, Newton EM, Kyriakis J, Kingston RE", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371453" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" } ] }, { "title": "Interplay of acetyltransferase EP300 and the proteasome system in regulating heat shock transcription factor 1.", "journal": "Cell", "date": "2014", "authors": "Raychaudhuri S, Loew C, Korner R, Pinkert S, Theis M, Hayer-Hartl M, Buchholz F, Hartl FU", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "reference": [ { "type": "PubMed", "id": "24581496", "url": "https://glygen.org/publication/PubMed/24581496" } ] }, { "title": "Heat shock factor 1, an inhibitor of non-homologous end joining repair.", "journal": "Oncotarget", "date": "2015", "authors": "Kang GY, Kim EH, Lee HJ, Gil NY, Cha HJ, Lee YS", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "reference": [ { "type": "PubMed", "id": "26359349", "url": "https://glygen.org/publication/PubMed/26359349" } ] }, { "title": "Insights into the regulation of heat shock transcription factor 1 SUMO-1 modification.", "journal": "Biochemical and biophysical research communications", "date": "2003", "authors": "Hilgarth RS, Hong Y, Park-Sarge OK, Sarge KD", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "12646186", "url": "https://glygen.org/publication/PubMed/12646186" } ] }, { "title": "Regulation of heat shock transcription factor 1 by stress-induced SUMO-1 modification.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Hong Y, Rogers R, Matunis MJ, Mayhew CN, Goodson ML, Park-Sarge OK, Sarge KD", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "reference": [ { "type": "PubMed", "id": "11514557", "url": "https://glygen.org/publication/PubMed/11514557" } ] }, { "title": "DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2004", "authors": "Boellmann F, Guettouche T, Guo Y, Fenna M, Mnayer L, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "15016915", "url": "https://glygen.org/publication/PubMed/15016915" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592", "database": "PubMed", "categories": [ "Other" ] }, { "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918", "database": "PubMed", "categories": [ "Other" ] }, { "id": "24581496", "url": "https://glygen.org/publication/PubMed/24581496", "database": "PubMed", "categories": [ "Other" ] }, { "id": "26359349", "url": "https://glygen.org/publication/PubMed/26359349", "database": "PubMed", "categories": [ "Other" ] }, { "id": "12646186", "url": "https://glygen.org/publication/PubMed/12646186", "database": "PubMed", "categories": [ "Other" ] }, { "id": "11514557", "url": "https://glygen.org/publication/PubMed/11514557", "database": "PubMed", "categories": [ "Other" ] }, { "id": "15016915", "url": "https://glygen.org/publication/PubMed/15016915", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "ASPGGSIDERPLSSSPLVRV", "down_seq": "EEPPSPPQSPRVEEASPGRP", "mutagenesis": [ { "sequence_org": "K", "sequence_mut": "A", "comment": "Induces derepression of transcriptional activity at control temperature.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" }, { "database": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" } ] }, { "sequence_org": "K", "sequence_mut": "Q", "comment": "No change in nuclear stress bodies localization. Increased protein abundance.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "24581496", "url": "https://glygen.org/publication/PubMed/24581496" } ] }, { "sequence_org": "K", "sequence_mut": "R", "comment": "Abolishes sumoylation. No effect on phosphorylation of S-303 nor of S-307. No change in subcellular location to nuclear stress granules upon heat shock. Loss of colocalization with SUMO1 to nuclear stress granules upon heat shock. Does not change interaction with XRCC5 and XRCC6. No effect on binding to HSE nor on transactivation of HSP70. Increases transcriptional activity in a DAXX-dependent manner. No change in protein abundance.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "24581496", "url": "https://glygen.org/publication/PubMed/24581496" }, { "database": "PubMed", "id": "26359349", "url": "https://glygen.org/publication/PubMed/26359349" }, { "database": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" }, { "database": "PubMed", "id": "12646186", "url": "https://glygen.org/publication/PubMed/12646186" }, { "database": "PubMed", "id": "11514557", "url": "https://glygen.org/publication/PubMed/11514557" }, { "database": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" }, { "database": "PubMed", "id": "15016915", "url": "https://glygen.org/publication/PubMed/15016915" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 6, "direction": "downstream", "id": "Q00613-1.292.292", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q00613-1.296.296", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "downstream", "id": "Q00613-1.297.297", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "upstream", "id": "Q00613-1.299.299", "categories": [ "mutagenesis_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q00613-1.300.300", "categories": [ "mutagenesis_flag" ] }, { "distance": 5, "direction": "upstream", "id": "Q00613-1.303.303", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 9, "direction": "upstream", "id": "Q00613-1.307.307", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 11, "direction": "upstream", "id": "Q00613-1.309.309", "categories": [ "mutagenesis_flag" ] }, { "distance": 13, "direction": "upstream", "id": "Q00613-1.311.311", "categories": [ "mutagenesis_flag" ] }, { "distance": 16, "direction": "upstream", "id": "Q00613-1.314.314", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 7 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.299.299", "start_pos": 299, "end_pos": 299, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Repression of human heat shock factor 1 activity at control temperature by phosphorylation.", "journal": "Genes & development", "date": "1996", "authors": "Knauf U, Newton EM, Kyriakis J, Kingston RE", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371453" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "E", "start_aa": "E", "up_seq": "SPGGSIDERPLSSSPLVRVK", "down_seq": "EPPSPPQSPRVEEASPGRPS", "mutagenesis": [ { "sequence_org": "E", "sequence_mut": "A", "comment": "No effect on repression of transcriptional activity at control temperature.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 7, "direction": "downstream", "id": "Q00613-1.292.292", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q00613-1.296.296", "categories": [ "mutagenesis_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q00613-1.297.297", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "downstream", "id": "Q00613-1.298.298", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "upstream", "id": "Q00613-1.300.300", "categories": [ "mutagenesis_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q00613-1.303.303", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 8, "direction": "upstream", "id": "Q00613-1.307.307", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 10, "direction": "upstream", "id": "Q00613-1.309.309", "categories": [ "mutagenesis_flag" ] }, { "distance": 12, "direction": "upstream", "id": "Q00613-1.311.311", "categories": [ "mutagenesis_flag" ] }, { "distance": 15, "direction": "upstream", "id": "Q00613-1.314.314", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 20, "direction": "upstream", "id": "Q00613-1.319.319", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.300.300", "start_pos": 300, "end_pos": 300, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Repression of human heat shock factor 1 activity at control temperature by phosphorylation.", "journal": "Genes & development", "date": "1996", "authors": "Knauf U, Newton EM, Kyriakis J, Kingston RE", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371453" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "E", "start_aa": "E", "up_seq": "PGGSIDERPLSSSPLVRVKE", "down_seq": "PPSPPQSPRVEEASPGRPSS", "mutagenesis": [ { "sequence_org": "E", "sequence_mut": "A", "comment": "Induces derepression of transcriptional activity at control temperature.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 8, "direction": "downstream", "id": "Q00613-1.292.292", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 4, "direction": "downstream", "id": "Q00613-1.296.296", "categories": [ "mutagenesis_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q00613-1.297.297", "categories": [ "mutagenesis_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q00613-1.298.298", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "downstream", "id": "Q00613-1.299.299", "categories": [ "mutagenesis_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q00613-1.303.303", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 7, "direction": "upstream", "id": "Q00613-1.307.307", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 9, "direction": "upstream", "id": "Q00613-1.309.309", "categories": [ "mutagenesis_flag" ] }, { "distance": 11, "direction": "upstream", "id": "Q00613-1.311.311", "categories": [ "mutagenesis_flag" ] }, { "distance": 14, "direction": "upstream", "id": "Q00613-1.314.314", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 19, "direction": "upstream", "id": "Q00613-1.319.319", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 20, "direction": "upstream", "id": "Q00613-1.320.320", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.303.303", "start_pos": 303, "end_pos": 303, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Repression of human heat shock factor 1 activity at control temperature by phosphorylation.", "journal": "Genes & development", "date": "1996", "authors": "Knauf U, Newton EM, Kyriakis J, Kingston RE", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371453" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" } ] }, { "title": "Transcriptional activation of heat shock factor HSF1 probed by phosphopeptide analysis of factor 32P-labeled in vivo.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Xia W, Guo Y, Vilaboa N, Zuo J, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "9535852", "url": "https://glygen.org/publication/PubMed/9535852" } ] }, { "title": "Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Hietakangas V, Ahlskog JK, Jakobsson AM, Hellesuo M, Sahlberg NM, Holmberg CI, Mikhailov A, Palvimo JJ, Pirkkala L, Sistonen L", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" } ] }, { "title": "Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation.", "journal": "Molecular and cellular biology", "date": "1997", "authors": "Kline MP, Morimoto RI", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "9121459", "url": "https://glygen.org/publication/PubMed/9121459" } ] }, { "title": "Insights into the regulation of heat shock transcription factor 1 SUMO-1 modification.", "journal": "Biochemical and biophysical research communications", "date": "2003", "authors": "Hilgarth RS, Hong Y, Park-Sarge OK, Sarge KD", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "12646186", "url": "https://glygen.org/publication/PubMed/12646186" } ] }, { "title": "HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression.", "journal": "Cancer research", "date": "2008", "authors": "Lee YJ, Kim EH, Lee JS, Jeoung D, Bae S, Kwon SH, Lee YS", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "18794143", "url": "https://glygen.org/publication/PubMed/18794143" } ] }, { "title": "Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Chu B, Soncin F, Price BD, Stevenson MA, Calderwood SK", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "8940068", "url": "https://glygen.org/publication/PubMed/8940068" } ] }, { "title": "Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Wang X, Grammatikakis N, Siganou A, Calderwood SK", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371453" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "12917326", "url": "https://glygen.org/publication/PubMed/12917326" } ] }, { "title": "Hydrophilic interaction chromatography reduces the complexity of the phosphoproteome and improves global phosphopeptide isolation and detection.", "journal": "Molecular & cellular proteomics : MCP", "date": "2008", "authors": "McNulty DE, Annan RS", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "18212344", "url": "https://glygen.org/publication/PubMed/18212344" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.", "journal": "Analytical chemistry", "date": "2009", "authors": "Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] }, { "title": "Phosphoproteomic analysis of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Brill LM, Xiong W, Lee KB, Ficarro SB, Crain A, Xu Y, Terskikh A, Snyder EY, Ding S", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis.", "journal": "Electrophoresis", "date": "2010", "authors": "Han G, Ye M, Liu H, Song C, Sun D, Wu Y, Jiang X, Chen R, Wang C, Wang L, Zou H", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ] }, { "title": "Repression of the HSP70B promoter by NFIL6, Ku70, and MAPK involves three complementary mechanisms.", "journal": "Biochemical and biophysical research communications", "date": "2001", "authors": "Tang D, Xie Y, Zhao M, Stevenson MA, Calderwood SK", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "11162511", "url": "https://glygen.org/publication/PubMed/11162511" } ] }, { "title": "Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress.", "journal": "BMC biochemistry", "date": "2005", "authors": "Guettouche T, Boellmann F, Lane WS, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371571", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371571" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" } ] }, { "title": "Regulation of heat shock protein 60 and 72 expression in the failing heart.", "journal": "Journal of molecular and cellular cardiology", "date": "2010", "authors": "Wang Y, Chen L, Hagiwara N, Knowlton AA", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "19945465", "url": "https://glygen.org/publication/PubMed/19945465" } ] }, { "title": "O-linked beta-N-acetylglucosamine (O-GlcNAc) regulates stress-induced heat shock protein expression in a GSK-3beta-dependent manner.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Kazemi Z, Chang H, Haserodt S, McKen C, Zachara NE", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "20926391", "url": "https://glygen.org/publication/PubMed/20926391" } ] }, { "title": "mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesis.", "journal": "PloS one", "date": "2012", "authors": "Chou SD, Prince T, Gong J, Calderwood SK", "evidence": [ { "database": "Reactome", "id": "R-HSA-3371571", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371571" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "22768106", "url": "https://glygen.org/publication/PubMed/22768106" } ] }, { "title": "PP2A-AMPK\u03b1-HSF1 axis regulates the metal-inducible expression of HSPs and ROS clearance.", "journal": "Cellular signalling", "date": "2014-04", "authors": "Zhu Xiao-nian, Chen Li-ping, Bai Qing, Ma Lu, Li Dao-chuan, Zhang Jin-miao, Gao Chen, Lei Zi-ning, Zhang Zheng-bao, Xing Xiu-mei, Liu Cai-xia, He Zhi-ni, Li Jie, Xiao Yong-mei, Zhang Ai-hua, Zeng Xiao-wen, Chen Wen", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "24412756", "url": "https://glygen.org/publication/PubMed/24412756" } ] }, { "title": "Peptide deformylase inhibitor actinonin reduces celastrol's HSP70 induction while synergizing proliferation inhibition in tumor cells.", "journal": "BMC cancer", "date": "2014", "authors": "Peng B, Zhang X, Cao F, Wang Y, Xu L, Cao L, Yang C, Li M, Uzan G, Zhang D", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "24589236", "url": "https://glygen.org/publication/PubMed/24589236" } ] }, { "title": "HSF1 regulation of beta-catenin in mammary cancer cells through control of HuR/elavL1 expression.", "journal": "Oncogene", "date": "2015", "authors": "Chou SD, Murshid A, Eguchi T, Gong J, Calderwood SK", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "24954509", "url": "https://glygen.org/publication/PubMed/24954509" } ] }, { "title": "IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.", "journal": "Scientific reports", "date": "2016", "authors": "Asano Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Tatebe S, Kitabayashi I, Tashiro F, Namiki H, Kondo T, Semba K, Aburatani H, Taya Y, Nakagama H, Ohki R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" } ] }, { "title": "Molecular mechanism of thermosensory function of human heat shock transcription factor Hsf1.", "journal": "eLife", "date": "2016", "authors": "Hentze N, Le Breton L, Wiesner J, Kempf G, Mayer MP", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "26785146", "url": "https://glygen.org/publication/PubMed/26785146" } ] }, { "title": "Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases.", "journal": "Molecular and cellular biology", "date": "2016", "authors": "Dayalan Naidu S, Sutherland C, Zhang Y, Risco A, de la Vega L, Caunt CJ, Hastie CJ, Lamont DJ, Torrente L, Chowdhry S, Benjamin IJ, Keyse SM, Cuenda A, Dinkova-Kostova AT", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "27354066", "url": "https://glygen.org/publication/PubMed/27354066" } ] }, { "title": "HSF1 phosphorylation by ERK/GSK3 suppresses RNF126 to sustain IGF-IIR expression for hypertension-induced cardiomyocyte hypertrophy.", "journal": "Journal of cellular physiology", "date": "2018", "authors": "Huang CY, Lee FL, Peng SF, Lin KH, Chen RJ, Ho TJ, Tsai FJ, Padma VV, Kuo WW, Huang CY", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "28383811", "url": "https://glygen.org/publication/PubMed/28383811" } ] }, { "title": "Phosphorylation of HSF1 at serine 326 residue is related to the maintenance of gynecologic cancer stem cells through expression of HSP27.", "journal": "Oncotarget", "date": "2017", "authors": "Yasuda K, Hirohashi Y, Mariya T, Murai A, Tabuchi Y, Kuroda T, Kusumoto H, Takaya A, Yamamoto E, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Tamura Y, Hirano H, Hasegawa T, Saito T, Sato N, Torigoe T", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "28415561", "url": "https://glygen.org/publication/PubMed/28415561" } ] }, { "title": "HSF1 phosphorylation by cyclosporin A confers hyperthermia sensitivity through suppression of HSP expression.", "journal": "Biochimica et biophysica acta. Gene regulatory mechanisms", "date": "2019", "authors": "Shao J, Han B, Cao P, Zhang B, Liu M, Li D, Zhou N, Hao Q, Duan X, Chang Y, Nakai A, Fan Y, Tan K", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "31054961", "url": "https://glygen.org/publication/PubMed/31054961" } ] }, { "title": "Decreased expression of FBXW7 by ERK1/2 activation in drug-resistant cancer cells confers transcriptional activation of MDR1 by suppression of ubiquitin degradation of HSF1.", "journal": "Cell death & disease", "date": "2020", "authors": "Mun GI, Choi E, Lee Y, Lee YS", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "32457290", "url": "https://glygen.org/publication/PubMed/32457290" } ] }, { "title": "Heat shock transcription factor 1 is SUMOylated in the activated trimeric state.", "journal": "The Journal of biological chemistry", "date": "2021", "authors": "Kmiecik Szymon W, Drzewicka Katarzyna, Melchior Frauke, Mayer Matthias P", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "33493517", "url": "https://glygen.org/publication/PubMed/33493517" } ] }, { "title": "Pan-Cancer Analysis of the Prognostic and Immunological Role of HSF1: A Potential Target for Survival and Immunotherapy.", "journal": "Oxidative medicine and cellular longevity", "date": "2021", "authors": "Chen F, Fan Y, Cao P, Liu B, Hou J, Zhang B, Tan K", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "34239690", "url": "https://glygen.org/publication/PubMed/34239690" } ] }, { "title": "Transcriptional activity of heat shock factor 1 at 37 degrees C is repressed through phosphorylation on two distinct serine residues by glycogen synthase kinase 3 and protein kinases Calpha and Czeta.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Chu B, Zhong R, Soncin F, Stevenson MA, Calderwood SK", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "9660838", "url": "https://glygen.org/publication/PubMed/9660838" } ] }, { "title": "PDSM, a motif for phosphorylation-dependent SUMO modification.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2006", "authors": "Hietakangas V, Anckar J, Blomster HA, Fujimoto M, Palvimo JJ, Nakai A, Sistonen L", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "16371476", "url": "https://glygen.org/publication/PubMed/16371476" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] }, { "title": "Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1.", "journal": "The EMBO journal", "date": "2001", "authors": "Holmberg CI, Hietakangas V, Mikhailov A, Rantanen JO, Kallio M, Meinander A, Hellman J, Morrice N, MacKintosh C, Morimoto RI, Eriksson JE, Sistonen L", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371571", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371571" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "11447121", "url": "https://glygen.org/publication/PubMed/11447121" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918", "database": "PubMed", "categories": [ "Other" ] }, { "id": "9535852", "url": "https://glygen.org/publication/PubMed/9535852", "database": "PubMed", "categories": [ "Other" ] }, { "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592", "database": "PubMed", "categories": [ "Other" ] }, { "id": "9121459", "url": "https://glygen.org/publication/PubMed/9121459", "database": "PubMed", "categories": [ "Other" ] }, { "id": "12646186", "url": "https://glygen.org/publication/PubMed/12646186", "database": "PubMed", "categories": [ "Other" ] }, { "id": "18794143", "url": "https://glygen.org/publication/PubMed/18794143", "database": "PubMed", "categories": [ "Other" ] }, { "id": "8940068", "url": "https://glygen.org/publication/PubMed/8940068", "database": "PubMed", "categories": [ "Other" ] }, { "id": "12917326", "url": "https://glygen.org/publication/PubMed/12917326", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "18212344", "url": "https://glygen.org/publication/PubMed/18212344", "database": "PubMed", "categories": [ "Other" ] }, { "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994", "database": "PubMed", "categories": [ "Other" ] }, { "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231", "database": "PubMed", "categories": [ "Other" ] }, { "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=Q00613", "database": "PRO", "categories": [ "Other" ] }, { "id": "11162511", "url": "https://glygen.org/publication/PubMed/11162511", "database": "PubMed", "categories": [ "Other" ] }, { "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19945465", "url": "https://glygen.org/publication/PubMed/19945465", "database": "PubMed", "categories": [ "Other" ] }, { "id": "20926391", "url": "https://glygen.org/publication/PubMed/20926391", "database": "PubMed", "categories": [ "Other" ] }, { "id": "22768106", "url": "https://glygen.org/publication/PubMed/22768106", "database": "PubMed", "categories": [ "Other" ] }, { "id": "24412756", "url": "https://glygen.org/publication/PubMed/24412756", "database": "PubMed", "categories": [ "Other" ] }, { "id": "24589236", "url": "https://glygen.org/publication/PubMed/24589236", "database": "PubMed", "categories": [ "Other" ] }, { "id": "24954509", "url": "https://glygen.org/publication/PubMed/24954509", "database": "PubMed", "categories": [ "Other" ] }, { "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925", "database": "PubMed", "categories": [ "Other" ] }, { "id": "26785146", "url": "https://glygen.org/publication/PubMed/26785146", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27354066", "url": "https://glygen.org/publication/PubMed/27354066", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28383811", "url": "https://glygen.org/publication/PubMed/28383811", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28415561", "url": "https://glygen.org/publication/PubMed/28415561", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31054961", "url": "https://glygen.org/publication/PubMed/31054961", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32457290", "url": "https://glygen.org/publication/PubMed/32457290", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33493517", "url": "https://glygen.org/publication/PubMed/33493517", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34239690", "url": "https://glygen.org/publication/PubMed/34239690", "database": "PubMed", "categories": [ "Other" ] }, { "id": "9660838", "url": "https://glygen.org/publication/PubMed/9660838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "16371476", "url": "https://glygen.org/publication/PubMed/16371476", "database": "PubMed", "categories": [ "Other" ] }, { "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163", "database": "PubMed", "categories": [ "Other" ] }, { "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569", "database": "PubMed", "categories": [ "Other" ] }, { "id": "11447121", "url": "https://glygen.org/publication/PubMed/11447121", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "SIDERPLSSSPLVRVKEEPP", "down_seq": "PPQSPRVEEASPGRPSSVDT", "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "No phosphorylation nor sumoylation. No change in nuclear stress granules subcellular location upon heat shock. Loss of colocalization with SUMO1 to nuclear stress granules upon heat shock. Slight decrease in transcriptional activity on heat treatment. No change in PLK1-induced phosphorylation in mitosis, induces derepression of transcription activation at control temperature, abolishes sumoylation and induces 2.5-fold increase in transcriptional activity on heat treatment; when associated with A-307.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" }, { "database": "PubMed", "id": "9535852", "url": "https://glygen.org/publication/PubMed/9535852" }, { "database": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" }, { "database": "PubMed", "id": "9121459", "url": "https://glygen.org/publication/PubMed/9121459" }, { "database": "PubMed", "id": "12646186", "url": "https://glygen.org/publication/PubMed/12646186" }, { "database": "PubMed", "id": "18794143", "url": "https://glygen.org/publication/PubMed/18794143" } ] }, { "sequence_org": "S", "sequence_mut": "D", "comment": "Mimics phosphorylation. No effect on in vitro sumoylation. Greatly increased transcriptional activity on heat induction. 5-fold derepression of transcriptional activity at control temperature; when associated with D-307.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" }, { "database": "PubMed", "id": "9535852", "url": "https://glygen.org/publication/PubMed/9535852" }, { "database": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" }, { "database": "PubMed", "id": "9121459", "url": "https://glygen.org/publication/PubMed/9121459" } ] }, { "sequence_org": "S", "sequence_mut": "G", "comment": "Leads to constitutive transactivation activity at room temperature. Inhibits interaction with YWHAE and increases cytoplasmic localization; when associated with G-307.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "8940068", "url": "https://glygen.org/publication/PubMed/8940068" }, { "database": "PubMed", "id": "12917326", "url": "https://glygen.org/publication/PubMed/12917326" } ] } ], "phosphorylation": [ { "kinase_uniprot_canonical_ac": "P49840-1", "kinase_gene_name": "GSK3A", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" }, { "database": "PubMed", "id": "18212344", "url": "https://glygen.org/publication/PubMed/18212344" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ], "site_lbl": "Ser303" }, { "kinase_uniprot_canonical_ac": "P49841-1", "kinase_gene_name": "GSK3B", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "8940068", "url": "https://glygen.org/publication/PubMed/8940068" } ], "site_lbl": "Ser303" }, { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by GSK3-beta", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" }, { "database": "PubMed", "id": "18212344", "url": "https://glygen.org/publication/PubMed/18212344" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" }, { "database": "PRO", "id": "Q00613", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=Q00613" }, { "database": "PubMed", "id": "12917326", "url": "https://glygen.org/publication/PubMed/12917326" }, { "database": "PubMed", "id": "9121459", "url": "https://glygen.org/publication/PubMed/9121459" }, { "database": "PubMed", "id": "11162511", "url": "https://glygen.org/publication/PubMed/11162511" }, { "database": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" }, { "database": "PubMed", "id": "19945465", "url": "https://glygen.org/publication/PubMed/19945465" }, { "database": "PubMed", "id": "20926391", "url": "https://glygen.org/publication/PubMed/20926391" }, { "database": "PubMed", "id": "22768106", "url": "https://glygen.org/publication/PubMed/22768106" }, { "database": "PubMed", "id": "24412756", "url": "https://glygen.org/publication/PubMed/24412756" }, { "database": "PubMed", "id": "24589236", "url": "https://glygen.org/publication/PubMed/24589236" }, { "database": "PubMed", "id": "24954509", "url": "https://glygen.org/publication/PubMed/24954509" }, { "database": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" }, { "database": "PubMed", "id": "26785146", "url": "https://glygen.org/publication/PubMed/26785146" }, { "database": "PubMed", "id": "27354066", "url": "https://glygen.org/publication/PubMed/27354066" }, { "database": "PubMed", "id": "28383811", "url": "https://glygen.org/publication/PubMed/28383811" }, { "database": "PubMed", "id": "28415561", "url": "https://glygen.org/publication/PubMed/28415561" }, { "database": "PubMed", "id": "31054961", "url": "https://glygen.org/publication/PubMed/31054961" }, { "database": "PubMed", "id": "32457290", "url": "https://glygen.org/publication/PubMed/32457290" }, { "database": "PubMed", "id": "33493517", "url": "https://glygen.org/publication/PubMed/33493517" }, { "database": "PubMed", "id": "34239690", "url": "https://glygen.org/publication/PubMed/34239690" }, { "database": "PubMed", "id": "9660838", "url": "https://glygen.org/publication/PubMed/9660838" }, { "database": "PubMed", "id": "16371476", "url": "https://glygen.org/publication/PubMed/16371476" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "PubMed", "id": "8940068", "url": "https://glygen.org/publication/PubMed/8940068" }, { "database": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" }, { "database": "PubMed", "id": "11447121", "url": "https://glygen.org/publication/PubMed/11447121" } ], "site_lbl": "Ser303" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag", "phosphorylation_flag" ], "glycosylation": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 11, "direction": "downstream", "id": "Q00613-1.292.292", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 7, "direction": "downstream", "id": "Q00613-1.296.296", "categories": [ "mutagenesis_flag" ] }, { "distance": 6, "direction": "downstream", "id": "Q00613-1.297.297", "categories": [ "mutagenesis_flag" ] }, { "distance": 5, "direction": "downstream", "id": "Q00613-1.298.298", "categories": [ "mutagenesis_flag" ] }, { "distance": 4, "direction": "downstream", "id": "Q00613-1.299.299", "categories": [ "mutagenesis_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q00613-1.300.300", "categories": [ "mutagenesis_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q00613-1.307.307", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 6, "direction": "upstream", "id": "Q00613-1.309.309", "categories": [ "mutagenesis_flag" ] }, { "distance": 8, "direction": "upstream", "id": "Q00613-1.311.311", "categories": [ "mutagenesis_flag" ] }, { "distance": 11, "direction": "upstream", "id": "Q00613-1.314.314", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 16, "direction": "upstream", "id": "Q00613-1.319.319", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 17, "direction": "upstream", "id": "Q00613-1.320.320", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 20, "direction": "upstream", "id": "Q00613-1.323.323", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 37 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.307.307", "start_pos": 307, "end_pos": 307, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Repression of human heat shock factor 1 activity at control temperature by phosphorylation.", "journal": "Genes & development", "date": "1996", "authors": "Knauf U, Newton EM, Kyriakis J, Kingston RE", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371453" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" } ] }, { "title": "Transcriptional activation of heat shock factor HSF1 probed by phosphopeptide analysis of factor 32P-labeled in vivo.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Xia W, Guo Y, Vilaboa N, Zuo J, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "9535852", "url": "https://glygen.org/publication/PubMed/9535852" } ] }, { "title": "Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Hietakangas V, Ahlskog JK, Jakobsson AM, Hellesuo M, Sahlberg NM, Holmberg CI, Mikhailov A, Palvimo JJ, Pirkkala L, Sistonen L", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" } ] }, { "title": "Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation.", "journal": "Molecular and cellular biology", "date": "1997", "authors": "Kline MP, Morimoto RI", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "9121459", "url": "https://glygen.org/publication/PubMed/9121459" } ] }, { "title": "Insights into the regulation of heat shock transcription factor 1 SUMO-1 modification.", "journal": "Biochemical and biophysical research communications", "date": "2003", "authors": "Hilgarth RS, Hong Y, Park-Sarge OK, Sarge KD", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "12646186", "url": "https://glygen.org/publication/PubMed/12646186" } ] }, { "title": "HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression.", "journal": "Cancer research", "date": "2008", "authors": "Lee YJ, Kim EH, Lee JS, Jeoung D, Bae S, Kwon SH, Lee YS", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "18794143", "url": "https://glygen.org/publication/PubMed/18794143" } ] }, { "title": "IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.", "journal": "Scientific reports", "date": "2016", "authors": "Asano Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Tatebe S, Kitabayashi I, Tashiro F, Namiki H, Kondo T, Semba K, Aburatani H, Taya Y, Nakagama H, Ohki R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" } ] }, { "title": "Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Chu B, Soncin F, Price BD, Stevenson MA, Calderwood SK", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "8940068", "url": "https://glygen.org/publication/PubMed/8940068" } ] }, { "title": "Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Wang X, Grammatikakis N, Siganou A, Calderwood SK", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371453" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "12917326", "url": "https://glygen.org/publication/PubMed/12917326" } ] }, { "title": "Hydrophilic interaction chromatography reduces the complexity of the phosphoproteome and improves global phosphopeptide isolation and detection.", "journal": "Molecular & cellular proteomics : MCP", "date": "2008", "authors": "McNulty DE, Annan RS", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "18212344", "url": "https://glygen.org/publication/PubMed/18212344" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.", "journal": "Analytical chemistry", "date": "2009", "authors": "Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] }, { "title": "Phosphoproteomic analysis of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Brill LM, Xiong W, Lee KB, Ficarro SB, Crain A, Xu Y, Terskikh A, Snyder EY, Ding S", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis.", "journal": "Electrophoresis", "date": "2010", "authors": "Han G, Ye M, Liu H, Song C, Sun D, Wu Y, Jiang X, Chen R, Wang C, Wang L, Zou H", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ] }, { "title": "Repression of the HSP70B promoter by NFIL6, Ku70, and MAPK involves three complementary mechanisms.", "journal": "Biochemical and biophysical research communications", "date": "2001", "authors": "Tang D, Xie Y, Zhao M, Stevenson MA, Calderwood SK", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "11162511", "url": "https://glygen.org/publication/PubMed/11162511" } ] }, { "title": "Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress.", "journal": "BMC biochemistry", "date": "2005", "authors": "Guettouche T, Boellmann F, Lane WS, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371571", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371571" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" } ] }, { "title": "Regulation of heat shock protein 60 and 72 expression in the failing heart.", "journal": "Journal of molecular and cellular cardiology", "date": "2010", "authors": "Wang Y, Chen L, Hagiwara N, Knowlton AA", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "19945465", "url": "https://glygen.org/publication/PubMed/19945465" } ] }, { "title": "Molecular mechanism of thermosensory function of human heat shock transcription factor Hsf1.", "journal": "eLife", "date": "2016", "authors": "Hentze N, Le Breton L, Wiesner J, Kempf G, Mayer MP", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "26785146", "url": "https://glygen.org/publication/PubMed/26785146" } ] }, { "title": "Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases.", "journal": "Molecular and cellular biology", "date": "2016", "authors": "Dayalan Naidu S, Sutherland C, Zhang Y, Risco A, de la Vega L, Caunt CJ, Hastie CJ, Lamont DJ, Torrente L, Chowdhry S, Benjamin IJ, Keyse SM, Cuenda A, Dinkova-Kostova AT", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "27354066", "url": "https://glygen.org/publication/PubMed/27354066" } ] }, { "title": "HSF1 phosphorylation by ERK/GSK3 suppresses RNF126 to sustain IGF-IIR expression for hypertension-induced cardiomyocyte hypertrophy.", "journal": "Journal of cellular physiology", "date": "2018", "authors": "Huang CY, Lee FL, Peng SF, Lin KH, Chen RJ, Ho TJ, Tsai FJ, Padma VV, Kuo WW, Huang CY", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "28383811", "url": "https://glygen.org/publication/PubMed/28383811" } ] }, { "title": "Phosphorylation of HSF1 at serine 326 residue is related to the maintenance of gynecologic cancer stem cells through expression of HSP27.", "journal": "Oncotarget", "date": "2017", "authors": "Yasuda K, Hirohashi Y, Mariya T, Murai A, Tabuchi Y, Kuroda T, Kusumoto H, Takaya A, Yamamoto E, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Tamura Y, Hirano H, Hasegawa T, Saito T, Sato N, Torigoe T", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "28415561", "url": "https://glygen.org/publication/PubMed/28415561" } ] }, { "title": "HSF1 phosphorylation by cyclosporin A confers hyperthermia sensitivity through suppression of HSP expression.", "journal": "Biochimica et biophysica acta. Gene regulatory mechanisms", "date": "2019", "authors": "Shao J, Han B, Cao P, Zhang B, Liu M, Li D, Zhou N, Hao Q, Duan X, Chang Y, Nakai A, Fan Y, Tan K", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "31054961", "url": "https://glygen.org/publication/PubMed/31054961" } ] }, { "title": "Decreased expression of FBXW7 by ERK1/2 activation in drug-resistant cancer cells confers transcriptional activation of MDR1 by suppression of ubiquitin degradation of HSF1.", "journal": "Cell death & disease", "date": "2020", "authors": "Mun GI, Choi E, Lee Y, Lee YS", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "32457290", "url": "https://glygen.org/publication/PubMed/32457290" } ] }, { "title": "Heat shock transcription factor 1 is SUMOylated in the activated trimeric state.", "journal": "The Journal of biological chemistry", "date": "2021", "authors": "Kmiecik Szymon W, Drzewicka Katarzyna, Melchior Frauke, Mayer Matthias P", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "33493517", "url": "https://glygen.org/publication/PubMed/33493517" } ] }, { "title": "Pan-Cancer Analysis of the Prognostic and Immunological Role of HSF1: A Potential Target for Survival and Immunotherapy.", "journal": "Oxidative medicine and cellular longevity", "date": "2021", "authors": "Chen F, Fan Y, Cao P, Liu B, Hou J, Zhang B, Tan K", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "34239690", "url": "https://glygen.org/publication/PubMed/34239690" } ] }, { "title": "Transcriptional activity of heat shock factor 1 at 37 degrees C is repressed through phosphorylation on two distinct serine residues by glycogen synthase kinase 3 and protein kinases Calpha and Czeta.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Chu B, Zhong R, Soncin F, Stevenson MA, Calderwood SK", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "9660838", "url": "https://glygen.org/publication/PubMed/9660838" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1.", "journal": "The EMBO journal", "date": "2001", "authors": "Holmberg CI, Hietakangas V, Mikhailov A, Rantanen JO, Kallio M, Meinander A, Hellman J, Morrice N, MacKintosh C, Morimoto RI, Eriksson JE, Sistonen L", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371571", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371571" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "11447121", "url": "https://glygen.org/publication/PubMed/11447121" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918", "database": "PubMed", "categories": [ "Other" ] }, { "id": "9535852", "url": "https://glygen.org/publication/PubMed/9535852", "database": "PubMed", "categories": [ "Other" ] }, { "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592", "database": "PubMed", "categories": [ "Other" ] }, { "id": "9121459", "url": "https://glygen.org/publication/PubMed/9121459", "database": "PubMed", "categories": [ "Other" ] }, { "id": "12646186", "url": "https://glygen.org/publication/PubMed/12646186", "database": "PubMed", "categories": [ "Other" ] }, { "id": "18794143", "url": "https://glygen.org/publication/PubMed/18794143", "database": "PubMed", "categories": [ "Other" ] }, { "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925", "database": "PubMed", "categories": [ "Other" ] }, { "id": "8940068", "url": "https://glygen.org/publication/PubMed/8940068", "database": "PubMed", "categories": [ "Other" ] }, { "id": "12917326", "url": "https://glygen.org/publication/PubMed/12917326", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "18212344", "url": "https://glygen.org/publication/PubMed/18212344", "database": "PubMed", "categories": [ "Other" ] }, { "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994", "database": "PubMed", "categories": [ "Other" ] }, { "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231", "database": "PubMed", "categories": [ "Other" ] }, { "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=Q00613", "database": "PRO", "categories": [ "Other" ] }, { "id": "11162511", "url": "https://glygen.org/publication/PubMed/11162511", "database": "PubMed", "categories": [ "Other" ] }, { "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19945465", "url": "https://glygen.org/publication/PubMed/19945465", "database": "PubMed", "categories": [ "Other" ] }, { "id": "26785146", "url": "https://glygen.org/publication/PubMed/26785146", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27354066", "url": "https://glygen.org/publication/PubMed/27354066", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28383811", "url": "https://glygen.org/publication/PubMed/28383811", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28415561", "url": "https://glygen.org/publication/PubMed/28415561", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31054961", "url": "https://glygen.org/publication/PubMed/31054961", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32457290", "url": "https://glygen.org/publication/PubMed/32457290", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33493517", "url": "https://glygen.org/publication/PubMed/33493517", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34239690", "url": "https://glygen.org/publication/PubMed/34239690", "database": "PubMed", "categories": [ "Other" ] }, { "id": "9660838", "url": "https://glygen.org/publication/PubMed/9660838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163", "database": "PubMed", "categories": [ "Other" ] }, { "id": "11447121", "url": "https://glygen.org/publication/PubMed/11447121", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "RPLSSSPLVRVKEEPPSPPQ", "down_seq": "PRVEEASPGRPSSVDTLLSP", "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "No phosphorylation. Does not reduce Ser-303 phosphorylation. 1.5% increase in transcriptional activity on heat-treatment. No change in PLK1-induced phosphorylation in mitosis, induces derepression of transcription activation at control temperature, abolishes sumoylation and induces 2.5-fold increase in transcriptional activity on heat treatment; when associated with A-303.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" }, { "database": "PubMed", "id": "9535852", "url": "https://glygen.org/publication/PubMed/9535852" }, { "database": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" }, { "database": "PubMed", "id": "9121459", "url": "https://glygen.org/publication/PubMed/9121459" }, { "database": "PubMed", "id": "12646186", "url": "https://glygen.org/publication/PubMed/12646186" }, { "database": "PubMed", "id": "18794143", "url": "https://glygen.org/publication/PubMed/18794143" } ] }, { "sequence_org": "S", "sequence_mut": "D", "comment": "5-fold derepression of transcriptional activity at control temperature; when associated with D-303. Decreased HSF1-induced expression of HSPA1A mRNA in a IER5-dependent manner; when associated with D-121; D-314; D-323 and D-367.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" }, { "database": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" }, { "database": "PubMed", "id": "9121459", "url": "https://glygen.org/publication/PubMed/9121459" } ] }, { "sequence_org": "S", "sequence_mut": "G", "comment": "Leads to constitutive transactivation activity at room temperature. Inhibits interaction with YWHAE and increases cytoplasmic localization; when associated with G-303.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "8940068", "url": "https://glygen.org/publication/PubMed/8940068" }, { "database": "PubMed", "id": "12917326", "url": "https://glygen.org/publication/PubMed/12917326" } ] } ], "phosphorylation": [ { "kinase_uniprot_canonical_ac": "P27361-1", "kinase_gene_name": "MAPK3", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "18212344", "url": "https://glygen.org/publication/PubMed/18212344" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" }, { "database": "PubMed", "id": "8940068", "url": "https://glygen.org/publication/PubMed/8940068" } ], "site_lbl": "Ser307" }, { "kinase_uniprot_canonical_ac": "P28482-1", "kinase_gene_name": "MAPK1", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "8940068", "url": "https://glygen.org/publication/PubMed/8940068" } ], "site_lbl": "Ser307" }, { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by MAPK3", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "18212344", "url": "https://glygen.org/publication/PubMed/18212344" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" }, { "database": "PubMed", "id": "8940068", "url": "https://glygen.org/publication/PubMed/8940068" }, { "database": "PRO", "id": "Q00613", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=Q00613" }, { "database": "PubMed", "id": "12917326", "url": "https://glygen.org/publication/PubMed/12917326" }, { "database": "PubMed", "id": "9121459", "url": "https://glygen.org/publication/PubMed/9121459" }, { "database": "PubMed", "id": "11162511", "url": "https://glygen.org/publication/PubMed/11162511" }, { "database": "PubMed", "id": "12646186", "url": "https://glygen.org/publication/PubMed/12646186" }, { "database": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" }, { "database": "PubMed", "id": "19945465", "url": "https://glygen.org/publication/PubMed/19945465" }, { "database": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" }, { "database": "PubMed", "id": "26785146", "url": "https://glygen.org/publication/PubMed/26785146" }, { "database": "PubMed", "id": "27354066", "url": "https://glygen.org/publication/PubMed/27354066" }, { "database": "PubMed", "id": "28383811", "url": "https://glygen.org/publication/PubMed/28383811" }, { "database": "PubMed", "id": "28415561", "url": "https://glygen.org/publication/PubMed/28415561" }, { "database": "PubMed", "id": "31054961", "url": "https://glygen.org/publication/PubMed/31054961" }, { "database": "PubMed", "id": "32457290", "url": "https://glygen.org/publication/PubMed/32457290" }, { "database": "PubMed", "id": "33493517", "url": "https://glygen.org/publication/PubMed/33493517" }, { "database": "PubMed", "id": "34239690", "url": "https://glygen.org/publication/PubMed/34239690" }, { "database": "PubMed", "id": "9660838", "url": "https://glygen.org/publication/PubMed/9660838" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" }, { "database": "PubMed", "id": "9535852", "url": "https://glygen.org/publication/PubMed/9535852" }, { "database": "PubMed", "id": "11447121", "url": "https://glygen.org/publication/PubMed/11447121" } ], "site_lbl": "Ser307" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag", "phosphorylation_flag" ], "glycosylation": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 15, "direction": "downstream", "id": "Q00613-1.292.292", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 11, "direction": "downstream", "id": "Q00613-1.296.296", "categories": [ "mutagenesis_flag" ] }, { "distance": 10, "direction": "downstream", "id": "Q00613-1.297.297", "categories": [ "mutagenesis_flag" ] }, { "distance": 9, "direction": "downstream", "id": "Q00613-1.298.298", "categories": [ "mutagenesis_flag" ] }, { "distance": 8, "direction": "downstream", "id": "Q00613-1.299.299", "categories": [ "mutagenesis_flag" ] }, { "distance": 7, "direction": "downstream", "id": "Q00613-1.300.300", "categories": [ "mutagenesis_flag" ] }, { "distance": 4, "direction": "downstream", "id": "Q00613-1.303.303", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q00613-1.309.309", "categories": [ "mutagenesis_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q00613-1.311.311", "categories": [ "mutagenesis_flag" ] }, { "distance": 7, "direction": "upstream", "id": "Q00613-1.314.314", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 12, "direction": "upstream", "id": "Q00613-1.319.319", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 13, "direction": "upstream", "id": "Q00613-1.320.320", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 16, "direction": "upstream", "id": "Q00613-1.323.323", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 19, "direction": "upstream", "id": "Q00613-1.326.326", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 30 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.309.309", "start_pos": 309, "end_pos": 309, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Repression of human heat shock factor 1 activity at control temperature by phosphorylation.", "journal": "Genes & development", "date": "1996", "authors": "Knauf U, Newton EM, Kyriakis J, Kingston RE", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371453" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "LSSSPLVRVKEEPPSPPQSP", "down_seq": "VEEASPGRPSSVDTLLSPTA", "mutagenesis": [ { "sequence_org": "R", "sequence_mut": "A", "comment": "No effect on repression of transcriptional activity at control temperature.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 17, "direction": "downstream", "id": "Q00613-1.292.292", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 13, "direction": "downstream", "id": "Q00613-1.296.296", "categories": [ "mutagenesis_flag" ] }, { "distance": 12, "direction": "downstream", "id": "Q00613-1.297.297", "categories": [ "mutagenesis_flag" ] }, { "distance": 11, "direction": "downstream", "id": "Q00613-1.298.298", "categories": [ "mutagenesis_flag" ] }, { "distance": 10, "direction": "downstream", "id": "Q00613-1.299.299", "categories": [ "mutagenesis_flag" ] }, { "distance": 9, "direction": "downstream", "id": "Q00613-1.300.300", "categories": [ "mutagenesis_flag" ] }, { "distance": 6, "direction": "downstream", "id": "Q00613-1.303.303", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q00613-1.307.307", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q00613-1.311.311", "categories": [ "mutagenesis_flag" ] }, { "distance": 5, "direction": "upstream", "id": "Q00613-1.314.314", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 10, "direction": "upstream", "id": "Q00613-1.319.319", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 11, "direction": "upstream", "id": "Q00613-1.320.320", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 14, "direction": "upstream", "id": "Q00613-1.323.323", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 17, "direction": "upstream", "id": "Q00613-1.326.326", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.311.311", "start_pos": 311, "end_pos": 311, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Repression of human heat shock factor 1 activity at control temperature by phosphorylation.", "journal": "Genes & development", "date": "1996", "authors": "Knauf U, Newton EM, Kyriakis J, Kingston RE", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371453" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "E", "start_aa": "E", "up_seq": "SSPLVRVKEEPPSPPQSPRV", "down_seq": "EASPGRPSSVDTLLSPTALI", "mutagenesis": [ { "sequence_org": "E", "sequence_mut": "A", "comment": "No effect neither on repression of transcriptional activity at control temperature nor on transcriptional activation upon heat shock.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "8946918", "url": "https://glygen.org/publication/PubMed/8946918" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "Q00613-1.292.292", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 15, "direction": "downstream", "id": "Q00613-1.296.296", "categories": [ "mutagenesis_flag" ] }, { "distance": 14, "direction": "downstream", "id": "Q00613-1.297.297", "categories": [ "mutagenesis_flag" ] }, { "distance": 13, "direction": "downstream", "id": "Q00613-1.298.298", "categories": [ "mutagenesis_flag" ] }, { "distance": 12, "direction": "downstream", "id": "Q00613-1.299.299", "categories": [ "mutagenesis_flag" ] }, { "distance": 11, "direction": "downstream", "id": "Q00613-1.300.300", "categories": [ "mutagenesis_flag" ] }, { "distance": 8, "direction": "downstream", "id": "Q00613-1.303.303", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 4, "direction": "downstream", "id": "Q00613-1.307.307", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q00613-1.309.309", "categories": [ "mutagenesis_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q00613-1.314.314", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 8, "direction": "upstream", "id": "Q00613-1.319.319", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 9, "direction": "upstream", "id": "Q00613-1.320.320", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 12, "direction": "upstream", "id": "Q00613-1.323.323", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 15, "direction": "upstream", "id": "Q00613-1.326.326", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.314.314", "start_pos": 314, "end_pos": 314, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Polo-like kinase 1 phosphorylates heat shock transcription factor 1 and mediates its nuclear translocation during heat stress.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Kim SA, Yoon JH, Lee SH, Ahn SG", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "15661742", "url": "https://glygen.org/publication/PubMed/15661742" } ] }, { "title": "IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.", "journal": "Scientific reports", "date": "2016", "authors": "Asano Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Tatebe S, Kitabayashi I, Tashiro F, Namiki H, Kondo T, Semba K, Aburatani H, Taya Y, Nakagama H, Ohki R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" } ] }, { "title": "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.", "journal": "Science signaling", "date": "2009", "authors": "Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" } ] }, { "title": "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.", "journal": "Journal of proteome research", "date": "2008", "authors": "Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR 3rd", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "18220336", "url": "https://glygen.org/publication/PubMed/18220336" } ] }, { "title": "Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress.", "journal": "BMC biochemistry", "date": "2005", "authors": "Guettouche T, Boellmann F, Lane WS, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371571", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371571" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Motif-specific sampling of phosphoproteomes.", "journal": "Journal of proteome research", "date": "2008", "authors": "Ruse CI, McClatchy DB, Lu B, Cociorva D, Motoyama A, Park SK, Yates JR 3rd", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "15661742", "url": "https://glygen.org/publication/PubMed/15661742", "database": "PubMed", "categories": [ "Other" ] }, { "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332", "database": "PubMed", "categories": [ "Other" ] }, { "id": "18220336", "url": "https://glygen.org/publication/PubMed/18220336", "database": "PubMed", "categories": [ "Other" ] }, { "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475", "database": "PubMed", "categories": [ "Other" ] }, { "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "LVRVKEEPPSPPQSPRVEEA", "down_seq": "PGRPSSVDTLLSPTALIDSI", "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "Weak decreased PLK1-induced phosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "15661742", "url": "https://glygen.org/publication/PubMed/15661742" } ] }, { "sequence_org": "S", "sequence_mut": "D", "comment": "Decreased HSF1-induced expression of HSPA1A mRNA in a IER5-dependent manner; when associated with D-121; D-307; D-323 and D-367.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" } ] } ], "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" }, { "database": "PubMed", "id": "18220336", "url": "https://glygen.org/publication/PubMed/18220336" }, { "database": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" } ], "site_lbl": "Ser314" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag", "phosphorylation_flag" ], "glycosylation": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 18, "direction": "downstream", "id": "Q00613-1.296.296", "categories": [ "mutagenesis_flag" ] }, { "distance": 17, "direction": "downstream", "id": "Q00613-1.297.297", "categories": [ "mutagenesis_flag" ] }, { "distance": 16, "direction": "downstream", "id": "Q00613-1.298.298", "categories": [ "mutagenesis_flag" ] }, { "distance": 15, "direction": "downstream", "id": "Q00613-1.299.299", "categories": [ "mutagenesis_flag" ] }, { "distance": 14, "direction": "downstream", "id": "Q00613-1.300.300", "categories": [ "mutagenesis_flag" ] }, { "distance": 11, "direction": "downstream", "id": "Q00613-1.303.303", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 7, "direction": "downstream", "id": "Q00613-1.307.307", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 5, "direction": "downstream", "id": "Q00613-1.309.309", "categories": [ "mutagenesis_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q00613-1.311.311", "categories": [ "mutagenesis_flag" ] }, { "distance": 5, "direction": "upstream", "id": "Q00613-1.319.319", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 6, "direction": "upstream", "id": "Q00613-1.320.320", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 9, "direction": "upstream", "id": "Q00613-1.323.323", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 12, "direction": "upstream", "id": "Q00613-1.326.326", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 8 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.319.319", "start_pos": 319, "end_pos": 319, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Polo-like kinase 1 phosphorylates heat shock transcription factor 1 and mediates its nuclear translocation during heat stress.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Kim SA, Yoon JH, Lee SH, Ahn SG", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "15661742", "url": "https://glygen.org/publication/PubMed/15661742" } ] }, { "title": "Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress.", "journal": "BMC biochemistry", "date": "2005", "authors": "Guettouche T, Boellmann F, Lane WS, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371571", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371571" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" } ] }, { "title": "Motif-specific sampling of phosphoproteomes.", "journal": "Journal of proteome research", "date": "2008", "authors": "Ruse CI, McClatchy DB, Lu B, Cociorva D, Motoyama A, Park SK, Yates JR 3rd", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "15661742", "url": "https://glygen.org/publication/PubMed/15661742", "database": "PubMed", "categories": [ "Other" ] }, { "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622", "database": "PubMed", "categories": [ "Other" ] }, { "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "EEPPSPPQSPRVEEASPGRP", "down_seq": "SVDTLLSPTALIDSILRESE", "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "Weak decreased PLK1-induced phosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "15661742", "url": "https://glygen.org/publication/PubMed/15661742" } ] } ], "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser319" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag", "phosphorylation_flag" ], "glycosylation": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 20, "direction": "downstream", "id": "Q00613-1.299.299", "categories": [ "mutagenesis_flag" ] }, { "distance": 19, "direction": "downstream", "id": "Q00613-1.300.300", "categories": [ "mutagenesis_flag" ] }, { "distance": 16, "direction": "downstream", "id": "Q00613-1.303.303", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 12, "direction": "downstream", "id": "Q00613-1.307.307", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 10, "direction": "downstream", "id": "Q00613-1.309.309", "categories": [ "mutagenesis_flag" ] }, { "distance": 8, "direction": "downstream", "id": "Q00613-1.311.311", "categories": [ "mutagenesis_flag" ] }, { "distance": 5, "direction": "downstream", "id": "Q00613-1.314.314", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 1, "direction": "upstream", "id": "Q00613-1.320.320", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q00613-1.323.323", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 7, "direction": "upstream", "id": "Q00613-1.326.326", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.320.320", "start_pos": 320, "end_pos": 320, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Protein kinase A binds and activates heat shock factor 1.", "journal": "PloS one", "date": "2010", "authors": "Murshid A, Chou SD, Prince T, Zhang Y, Bharti A, Calderwood SK", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "21085490", "url": "https://glygen.org/publication/PubMed/21085490" } ] }, { "title": "Motif-specific sampling of phosphoproteomes.", "journal": "Journal of proteome research", "date": "2008", "authors": "Ruse CI, McClatchy DB, Lu B, Cociorva D, Motoyama A, Park SK, Yates JR 3rd", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Protein kinase A regulates molecular chaperone transcription and protein aggregation.", "journal": "PloS one", "date": "2011", "authors": "Zhang Y, Murshid A, Prince T, Calderwood SK", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "22216146", "url": "https://glygen.org/publication/PubMed/22216146" } ] }, { "title": "mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesis.", "journal": "PloS one", "date": "2012", "authors": "Chou SD, Prince T, Gong J, Calderwood SK", "evidence": [ { "database": "Reactome", "id": "R-HSA-3371571", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371571" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "22768106", "url": "https://glygen.org/publication/PubMed/22768106" } ] }, { "title": "IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.", "journal": "Scientific reports", "date": "2016", "authors": "Asano Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Tatebe S, Kitabayashi I, Tashiro F, Namiki H, Kondo T, Semba K, Aburatani H, Taya Y, Nakagama H, Ohki R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" } ] }, { "title": "Heat Shock Factor 1 Mediates Latent HIV Reactivation.", "journal": "Scientific reports", "date": "2016", "authors": "Pan XY, Zhao W, Zeng XY, Lin J, Li MM, Shen XT, Liu SW", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "27189267", "url": "https://glygen.org/publication/PubMed/27189267" } ] }, { "title": "Phosphorylation of HSF1 at serine 326 residue is related to the maintenance of gynecologic cancer stem cells through expression of HSP27.", "journal": "Oncotarget", "date": "2017", "authors": "Yasuda K, Hirohashi Y, Mariya T, Murai A, Tabuchi Y, Kuroda T, Kusumoto H, Takaya A, Yamamoto E, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Tamura Y, Hirano H, Hasegawa T, Saito T, Sato N, Torigoe T", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "28415561", "url": "https://glygen.org/publication/PubMed/28415561" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "21085490", "url": "https://glygen.org/publication/PubMed/21085490", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278", "database": "PubMed", "categories": [ "Other" ] }, { "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231", "database": "PubMed", "categories": [ "Other" ] }, { "id": "22216146", "url": "https://glygen.org/publication/PubMed/22216146", "database": "PubMed", "categories": [ "Other" ] }, { "id": "22768106", "url": "https://glygen.org/publication/PubMed/22768106", "database": "PubMed", "categories": [ "Other" ] }, { "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27189267", "url": "https://glygen.org/publication/PubMed/27189267", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28415561", "url": "https://glygen.org/publication/PubMed/28415561", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "EPPSPPQSPRVEEASPGRPS", "down_seq": "VDTLLSPTALIDSILRESEP", "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "Decreased nuclear localization and transcriptional activity upon heat shock.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "21085490", "url": "https://glygen.org/publication/PubMed/21085490" } ] }, { "sequence_org": "S", "sequence_mut": "D", "comment": "Increased nuclear localization and transcriptional activity upon heat shock.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "21085490", "url": "https://glygen.org/publication/PubMed/21085490" } ] } ], "phosphorylation": [ { "kinase_uniprot_canonical_ac": "P17612-1", "kinase_gene_name": "PRKACA", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "21085490", "url": "https://glygen.org/publication/PubMed/21085490" } ], "site_lbl": "Ser320" }, { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PKA", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "21085490", "url": "https://glygen.org/publication/PubMed/21085490" }, { "database": "PubMed", "id": "22216146", "url": "https://glygen.org/publication/PubMed/22216146" }, { "database": "PubMed", "id": "22768106", "url": "https://glygen.org/publication/PubMed/22768106" }, { "database": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" }, { "database": "PubMed", "id": "27189267", "url": "https://glygen.org/publication/PubMed/27189267" }, { "database": "PubMed", "id": "28415561", "url": "https://glygen.org/publication/PubMed/28415561" } ], "site_lbl": "Ser320" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag", "phosphorylation_flag" ], "glycosylation": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 20, "direction": "downstream", "id": "Q00613-1.300.300", "categories": [ "mutagenesis_flag" ] }, { "distance": 17, "direction": "downstream", "id": "Q00613-1.303.303", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 13, "direction": "downstream", "id": "Q00613-1.307.307", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 11, "direction": "downstream", "id": "Q00613-1.309.309", "categories": [ "mutagenesis_flag" ] }, { "distance": 9, "direction": "downstream", "id": "Q00613-1.311.311", "categories": [ "mutagenesis_flag" ] }, { "distance": 6, "direction": "downstream", "id": "Q00613-1.314.314", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 1, "direction": "downstream", "id": "Q00613-1.319.319", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q00613-1.323.323", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 6, "direction": "upstream", "id": "Q00613-1.326.326", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 8 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.323.323", "start_pos": 323, "end_pos": 323, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.", "journal": "Scientific reports", "date": "2016", "authors": "Asano Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Tatebe S, Kitabayashi I, Tashiro F, Namiki H, Kondo T, Semba K, Aburatani H, Taya Y, Nakagama H, Ohki R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" } ] }, { "title": "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.", "journal": "Cell", "date": "2006", "authors": "Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ] }, { "title": "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.", "journal": "Science signaling", "date": "2009", "authors": "Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" } ] }, { "title": "Phosphoproteomic analysis of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Brill LM, Xiong W, Lee KB, Ficarro SB, Crain A, Xu Y, Terskikh A, Snyder EY, Ding S", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925", "database": "PubMed", "categories": [ "Other" ] }, { "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994", "database": "PubMed", "categories": [ "Other" ] }, { "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SPPQSPRVEEASPGRPSSVD", "down_seq": "LLSPTALIDSILRESEPAPA", "mutagenesis": [ { "sequence_org": "T", "sequence_mut": "D", "comment": "Decreased HSF1-induced expression of HSPA1A mRNA in a IER5-dependent manner; when associated with D-121; D-307; D-314 and D-367.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" } ] } ], "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" } ], "site_lbl": "Thr323" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag", "phosphorylation_flag" ], "glycosylation": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 20, "direction": "downstream", "id": "Q00613-1.303.303", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 16, "direction": "downstream", "id": "Q00613-1.307.307", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 14, "direction": "downstream", "id": "Q00613-1.309.309", "categories": [ "mutagenesis_flag" ] }, { "distance": 12, "direction": "downstream", "id": "Q00613-1.311.311", "categories": [ "mutagenesis_flag" ] }, { "distance": 9, "direction": "downstream", "id": "Q00613-1.314.314", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 4, "direction": "downstream", "id": "Q00613-1.319.319", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q00613-1.320.320", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q00613-1.326.326", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.326.326", "start_pos": 326, "end_pos": 326, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2004", "authors": "Boellmann F, Guettouche T, Guo Y, Fenna M, Mnayer L, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "15016915", "url": "https://glygen.org/publication/PubMed/15016915" } ] }, { "title": "Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress.", "journal": "BMC biochemistry", "date": "2005", "authors": "Guettouche T, Boellmann F, Lane WS, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371571", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371571" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" } ] }, { "title": "Heat shock factor 1, an inhibitor of non-homologous end joining repair.", "journal": "Oncotarget", "date": "2015", "authors": "Kang GY, Kim EH, Lee HJ, Gil NY, Cha HJ, Lee YS", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "reference": [ { "type": "PubMed", "id": "26359349", "url": "https://glygen.org/publication/PubMed/26359349" } ] }, { "title": "Polo-like kinase 1 phosphorylates heat shock transcription factor 1 and mediates its nuclear translocation during heat stress.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Kim SA, Yoon JH, Lee SH, Ahn SG", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "15661742", "url": "https://glygen.org/publication/PubMed/15661742" } ] }, { "title": "Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases.", "journal": "Molecular and cellular biology", "date": "2016", "authors": "Dayalan Naidu S, Sutherland C, Zhang Y, Risco A, de la Vega L, Caunt CJ, Hastie CJ, Lamont DJ, Torrente L, Chowdhry S, Benjamin IJ, Keyse SM, Cuenda A, Dinkova-Kostova AT", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "27354066", "url": "https://glygen.org/publication/PubMed/27354066" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Protein kinase A binds and activates heat shock factor 1.", "journal": "PloS one", "date": "2010", "authors": "Murshid A, Chou SD, Prince T, Zhang Y, Bharti A, Calderwood SK", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "21085490", "url": "https://glygen.org/publication/PubMed/21085490" } ] }, { "title": "Inhibition of the heat shock response by PI103 enhances the cytotoxicity of arsenic trioxide.", "journal": "Toxicological sciences : an official journal of the Society of Toxicology", "date": "2012", "authors": "Yih LH, Hsu NC, Kuo HH, Wu YC", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "22496356", "url": "https://glygen.org/publication/PubMed/22496356" } ] }, { "title": "mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesis.", "journal": "PloS one", "date": "2012", "authors": "Chou SD, Prince T, Gong J, Calderwood SK", "evidence": [ { "database": "Reactome", "id": "R-HSA-3371571", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371571" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "22768106", "url": "https://glygen.org/publication/PubMed/22768106" } ] }, { "title": "Hyperthermia stress activates heat shock protein expression via propyl isomerase 1 regulation with heat shock factor 1.", "journal": "Molecular and cellular biology", "date": "2013", "authors": "Wang HY, Fu JC, Lee YC, Lu PJ", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "24126052", "url": "https://glygen.org/publication/PubMed/24126052" } ] }, { "title": "Deregulation of DNA-dependent protein kinase catalytic subunit contributes to human hepatocarcinogenesis development and has a putative prognostic value.", "journal": "British journal of cancer", "date": "2013", "authors": "Evert M, Frau M, Tomasi ML, Latte G, Simile MM, Seddaiu MA, Zimmermann A, Ladu S, Staniscia T, Brozzetti S, Solinas G, Dombrowski F, Feo F, Pascale RM, Calvisi DF", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "24136149", "url": "https://glygen.org/publication/PubMed/24136149" } ] }, { "title": "Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells.", "journal": "Oncogene", "date": "2015", "authors": "Carpenter RL, Paw I, Dewhirst MW, Lo HW", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "24469056", "url": "https://glygen.org/publication/PubMed/24469056" } ] }, { "title": "The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection.", "journal": "PLoS pathogens", "date": "2014", "authors": "Filone CM, Caballero IS, Dower K, Mendillo ML, Cowley GS, Santagata S, Rozelle DK, Yen J, Rubins KH, Hacohen N, Root DE, Hensley LE, Connor J", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "24516381", "url": "https://glygen.org/publication/PubMed/24516381" } ] }, { "title": "Peptide deformylase inhibitor actinonin reduces celastrol's HSP70 induction while synergizing proliferation inhibition in tumor cells.", "journal": "BMC cancer", "date": "2014", "authors": "Peng B, Zhang X, Cao F, Wang Y, Xu L, Cao L, Yang C, Li M, Uzan G, Zhang D", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "24589236", "url": "https://glygen.org/publication/PubMed/24589236" } ] }, { "title": "A gain-of-function mutant p53-HSF1 feed forward circuit governs adaptation of cancer cells to proteotoxic stress.", "journal": "Cell death & disease", "date": "2014", "authors": "Li D, Yallowitz A, Ozog L, Marchenko N", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "24763051", "url": "https://glygen.org/publication/PubMed/24763051" } ] }, { "title": "HSF1 regulation of beta-catenin in mammary cancer cells through control of HuR/elavL1 expression.", "journal": "Oncogene", "date": "2015", "authors": "Chou SD, Murshid A, Eguchi T, Gong J, Calderwood SK", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "24954509", "url": "https://glygen.org/publication/PubMed/24954509" } ] }, { "title": "Upregulation of heat shock factor 1 transcription activity is associated with hepatocellular carcinoma progression.", "journal": "Molecular medicine reports", "date": "2014", "authors": "Li S, Ma W, Fei T, Lou Q, Zhang Y, Cui X, Qin X, Zhang J, Liu G, Dong Z, Ma Y, Song Z, Hu Y", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "25199534", "url": "https://glygen.org/publication/PubMed/25199534" } ] }, { "title": "Modulation of the maladaptive stress response to manage diseases of protein folding.", "journal": "PLoS biology", "date": "2014", "authors": "Roth DM, Hutt DM, Tong J, Bouchecareilh M, Wang N, Seeley T, Dekkers JF, Beekman JM, Garza D, Drew L, Masliah E, Morimoto RI, Balch WE", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "25406061", "url": "https://glygen.org/publication/PubMed/25406061" } ] }, { "title": "HSPB1 as a novel regulator of ferroptotic cancer cell death.", "journal": "Oncogene", "date": "2015", "authors": "Sun X, Ou Z, Xie M, Kang R, Fan Y, Niu X, Wang H, Cao L, Tang D", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "25728673", "url": "https://glygen.org/publication/PubMed/25728673" } ] }, { "title": "ERK-dependent phosphorylation of HSF1 mediates chemotherapeutic resistance to benzimidazole carbamates in colorectal cancer cells.", "journal": "Anti-cancer drugs", "date": "2015", "authors": "Wales CT, Taylor FR, Higa AT, McAllister HA, Jacobs AT", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "25811962", "url": "https://glygen.org/publication/PubMed/25811962" } ] }, { "title": "Glucose regulates heat shock factor 1 transcription activity via mTOR pathway in HCC cell lines.", "journal": "Cell biology international", "date": "2015", "authors": "Ma W, Zhang Y, Mu H, Qing X, Li S, Cui X, Lou Q, Ma Y, Pu H, Hu Y", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "26010766", "url": "https://glygen.org/publication/PubMed/26010766" } ] }, { "title": "RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy.", "journal": "Autophagy", "date": "2015", "authors": "Luan Q, Jin L, Jiang CC, Tay KH, Lai F, Liu XY, Liu YL, Guo ST, Li CY, Yan XG, Tseng HY, Zhang XD", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "26018731", "url": "https://glygen.org/publication/PubMed/26018731" } ] }, { "title": "IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.", "journal": "Scientific reports", "date": "2016", "authors": "Asano Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Tatebe S, Kitabayashi I, Tashiro F, Namiki H, Kondo T, Semba K, Aburatani H, Taya Y, Nakagama H, Ohki R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" } ] }, { "title": "HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth.", "journal": "Nature cell biology", "date": "2016", "authors": "Su KH, Cao J, Tang Z, Dai S, He Y, Sampson SB, Benjamin IJ, Dai C", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "27043084", "url": "https://glygen.org/publication/PubMed/27043084" } ] }, { "title": "X66, a novel N-terminal heat shock protein 90 inhibitor, exerts antitumor effects without induction of heat shock response.", "journal": "Oncotarget", "date": "2016", "authors": "Zhao Z, Zhu J, Quan H, Wang G, Li B, Zhu W, Xie C, Lou L", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "27105490", "url": "https://glygen.org/publication/PubMed/27105490" } ] }, { "title": "Formaldehyde Is a Potent Proteotoxic Stressor Causing Rapid Heat Shock Transcription Factor 1 Activation and Lys48-Linked Polyubiquitination of Proteins.", "journal": "The American journal of pathology", "date": "2016", "authors": "Ortega-Atienza S, Rubis B, McCarthy C, Zhitkovich A", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "27639166", "url": "https://glygen.org/publication/PubMed/27639166" } ] }, { "title": "ErbB2 inhibition by lapatinib promotes degradation of mutant p53 protein in cancer cells.", "journal": "Oncotarget", "date": "2017", "authors": "Li D, Marchenko ND", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "27791982", "url": "https://glygen.org/publication/PubMed/27791982" } ] }, { "title": "The Heat Shock Transcription Factor HSF1 Induces Ovarian Cancer Epithelial-Mesenchymal Transition in a 3D Spheroid Growth Model.", "journal": "PloS one", "date": "2016", "authors": "Powell CD, Paullin TR, Aoisa C, Menzie CJ, Ubaldini A, Westerheide SD", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "27997575", "url": "https://glygen.org/publication/PubMed/27997575" } ] }, { "title": "20S immunoproteasomes remove formaldehyde-damaged cytoplasmic proteins suppressing caspase-independent cell death.", "journal": "Scientific reports", "date": "2017", "authors": "Ortega-Atienza S, Krawic C, Watts L, McCarthy C, Luczak MW, Zhitkovich A", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "28381880", "url": "https://glygen.org/publication/PubMed/28381880" } ] }, { "title": "Phosphorylation of HSF1 at serine 326 residue is related to the maintenance of gynecologic cancer stem cells through expression of HSP27.", "journal": "Oncotarget", "date": "2017", "authors": "Yasuda K, Hirohashi Y, Mariya T, Murai A, Tabuchi Y, Kuroda T, Kusumoto H, Takaya A, Yamamoto E, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Tamura Y, Hirano H, Hasegawa T, Saito T, Sato N, Torigoe T", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "28415561", "url": "https://glygen.org/publication/PubMed/28415561" } ] }, { "title": "The small-molecule kinase inhibitor D11 counteracts 17-AAG-mediated up-regulation of HSP70 in brain cancer cells.", "journal": "PloS one", "date": "2017", "authors": "Schaefer S, Svenstrup TH, Guerra B", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "28542269", "url": "https://glygen.org/publication/PubMed/28542269" } ] }, { "title": "piR-823 contributes to colorectal tumorigenesis by enhancing the transcriptional activity of HSF1.", "journal": "Cancer science", "date": "2017", "authors": "Yin J, Jiang XY, Qi W, Ji CG, Xie XL, Zhang DX, Cui ZJ, Wang CK, Bai Y, Wang J, Jiang HQ", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "28618124", "url": "https://glygen.org/publication/PubMed/28618124" } ] }, { "title": "mTORC2/AKT/HSF1/HuR constitute a feed-forward loop regulating Rictor expression and tumor growth in glioblastoma.", "journal": "Oncogene", "date": "2018", "authors": "Holmes B, Benavides-Serrato A, Freeman RS, Landon KA, Bashir T, Nishimura RN, Gera J", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "29059166", "url": "https://glygen.org/publication/PubMed/29059166" } ] }, { "title": "Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth.", "journal": "Oncotarget", "date": "2017", "authors": "Carpenter RL, Sirkisoon S, Zhu D, Rimkus T, Harrison A, Anderson A, Paw I, Qasem S, Xing F, Liu Y, Chan M, Metheny-Barlow L, Pasche BC, Debinski W, Watabe K, Lo HW", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "29088759", "url": "https://glygen.org/publication/PubMed/29088759" } ] }, { "title": "Fibronectin is a stress responsive gene regulated by HSF1 in response to geldanamycin.", "journal": "Scientific reports", "date": "2017", "authors": "Dhanani KCH, Samson WJ, Edkins AL", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "29247221", "url": "https://glygen.org/publication/PubMed/29247221" } ] }, { "title": "TG02 inhibits proteasome inhibitor-induced HSF1 serine 326 phosphorylation and heat shock response in multiple myeloma.", "journal": "Blood advances", "date": "2017", "authors": "Shah SP, Nooka AK, Lonial S, Boise LH", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "29296831", "url": "https://glygen.org/publication/PubMed/29296831" } ] }, { "title": "Cellular stress induces cancer stem-like cells through expression of DNAJB8 by activation of heat shock factor 1.", "journal": "Cancer science", "date": "2018", "authors": "Kusumoto H, Hirohashi Y, Nishizawa S, Yamashita M, Yasuda K, Murai A, Takaya A, Mori T, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Kondo T, Sato N, Hara I, Torigoe T", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "29316077", "url": "https://glygen.org/publication/PubMed/29316077" } ] }, { "title": "GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth.", "journal": "Cancer cell", "date": "2018", "authors": "Li L, Zeng Q, Bhutkar A, Galvan JA, Karamitopoulou E, Noordermeer D, Peng MW, Piersigilli A, Perren A, Zlobec I, Robinson H, Iruela-Arispe ML, Hanahan D", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "29606348", "url": "https://glygen.org/publication/PubMed/29606348" } ] }, { "title": "Heat shock factor 1 confers resistance to lapatinib in ERBB2-positive breast cancer cells.", "journal": "Cell death & disease", "date": "2018", "authors": "Yallowitz A, Ghaleb A, Garcia L, Alexandrova EM, Marchenko N", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "29799521", "url": "https://glygen.org/publication/PubMed/29799521" } ] }, { "title": "Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia.", "journal": "Nature medicine", "date": "2018", "authors": "Kourtis N, Lazaris C, Hockemeyer K, Balandran JC, Jimenez AR, Mullenders J, Gong Y, Trimarchi T, Bhatt K, Hu H, Shrestha L, Ambesi-Impiombato A, Kelliher M, Paietta E, Chiosis G, Guzman ML, Ferrando AA, Tsirigos A, Aifantis I", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "30038221", "url": "https://glygen.org/publication/PubMed/30038221" } ] }, { "title": "Intrinsic proteotoxic stress levels vary and act as a predictive marker for sensitivity of cancer cells to Hsp90 inhibition.", "journal": "PloS one", "date": "2018", "authors": "Pastorek M, Muller P, Coates PJ, Vojtesek B", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "30138434", "url": "https://glygen.org/publication/PubMed/30138434" } ] }, { "title": "Transcriptional Regulation of Selenoprotein F by Heat Shock Factor 1 during Selenium Supplementation and Stress Response.", "journal": "Cells", "date": "2019", "authors": "Ren B, Huang Y, Zou C, Wu Y, Huang Y, Ni J, Tian J", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "31109102", "url": "https://glygen.org/publication/PubMed/31109102" } ] }, { "title": "17\u03b2-Estradiol Activates HSF1 via MAPK Signaling in ER\u03b1-Positive Breast Cancer Cells.", "journal": "Cancers", "date": "2019-10-11", "authors": "Vydra Natalia, Janus Patryk, Toma-Jonik Agnieszka, Stokowy Tomasz, Mrowiec Katarzyna, Korfanty Joanna, D\u0142ugajczyk Anna, Wojta\u015b Bartosz, Gielniewski Bart\u0142omiej, Wid\u0142ak Wies\u0142awa", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "31614463", "url": "https://glygen.org/publication/PubMed/31614463" } ] }, { "title": "HSF1 is required for induction of mitochondrial chaperones during the mitochondrial unfolded protein response.", "journal": "FEBS open bio", "date": "2020-06", "authors": "Katiyar Arpit, Fujimoto Mitsuaki, Tan Ke, Kurashima Ai, Srivastava Pratibha, Okada Mariko, Takii Ryosuke, Nakai Akira", "evidence": [ { "database": "Reactome", "id": "R-HSA-9841251", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9841251" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "32302062", "url": "https://glygen.org/publication/PubMed/32302062" } ] }, { "title": "Heat shock response regulates stimulus-specificity and sensitivity of the pro-inflammatory NF-\u03baB signalling.", "journal": "Cell communication and signaling : CCS", "date": "2020-05-24", "authors": "Paszek Anna, Kardy\u0144ska Ma\u0142gorzata, Bagnall James, \u015amieja Jaros\u0142aw, Spiller David G, Wid\u0142ak Piotr, Kimmel Marek, Widlak Wieslawa, Paszek Pawel", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "32448393", "url": "https://glygen.org/publication/PubMed/32448393" } ] }, { "title": "Decreased expression of FBXW7 by ERK1/2 activation in drug-resistant cancer cells confers transcriptional activation of MDR1 by suppression of ubiquitin degradation of HSF1.", "journal": "Cell death & disease", "date": "2020", "authors": "Mun GI, Choi E, Lee Y, Lee YS", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "32457290", "url": "https://glygen.org/publication/PubMed/32457290" } ] }, { "title": "Heat shock factor 1 (HSF1-pSer326) predicts response to bortezomib-containing chemotherapy in pediatric AML: a COG report.", "journal": "Blood", "date": "2021-02-25", "authors": "Hoff Fieke W, van Dijk Anneke D, Qiu Yihua, Ruvolo Peter P, Gerbing Robert B, Leonti Amanda R, Jenkins Gaye N, Gamis Alan S, Aplenc Richard, Kolb E Anders, Alonzo Todd A, Meshinchi Soheil, de Bont Eveline S J M, Bruggeman Sophia W M, Kornblau Steven M, Horton Terzah M", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "32959058", "url": "https://glygen.org/publication/PubMed/32959058" } ] }, { "title": "Thrombospondin 4/integrin \u03b12/HSF1 axis promotes proliferation and cancer stem-like traits of gallbladder cancer by enhancing reciprocal crosstalk between cancer-associated fibroblasts and tumor cells.", "journal": "Journal of experimental & clinical cancer research : CR", "date": "2021-01-06", "authors": "Shi Yu, Sun Liankang, Zhang Rui, Hu Yuan, Wu Yinying, Dong Xuyuan, Dong Danfeng, Chen Chen, Geng Zhimin, Li Enxiao, Fan Yangwei", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "33407730", "url": "https://glygen.org/publication/PubMed/33407730" } ] }, { "title": "AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation.", "journal": "The FEBS journal", "date": "2022-07", "authors": "Lu Wen-Cheng, Omari Ramsey, Ray Haimanti, Wang John, Williams Imade, Jacobs Curteisha, Hockaden Natasha, Bochman Matthew L, Carpenter Richard L", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "35080342", "url": "https://glygen.org/publication/PubMed/35080342" } ] }, { "title": "Zinc supplementation prior to heat shock enhances HSP70 synthesis through HSF1 phosphorylation at serine 326 in human peripheral mononuclear cells.", "journal": "Food & function", "date": "2022-08-30", "authors": "Peng-Winkler Yifan, B\u00fcttgenbach Anna, Rink Lothar, Wessels Inga", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "35959699", "url": "https://glygen.org/publication/PubMed/35959699" } ] }, { "title": "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.", "journal": "Science signaling", "date": "2009", "authors": "Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "15016915", "url": "https://glygen.org/publication/PubMed/15016915", "database": "PubMed", "categories": [ "Other" ] }, { "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475", "database": "PubMed", "categories": [ "Other" ] }, { "id": "26359349", "url": "https://glygen.org/publication/PubMed/26359349", "database": "PubMed", "categories": [ "Other" ] }, { "id": "15661742", "url": "https://glygen.org/publication/PubMed/15661742", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27354066", "url": "https://glygen.org/publication/PubMed/27354066", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622", "database": "PubMed", "categories": [ "Other" ] }, { "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231", "database": "PubMed", "categories": [ "Other" ] }, { "id": "21085490", "url": "https://glygen.org/publication/PubMed/21085490", "database": "PubMed", "categories": [ "Other" ] }, { "id": "22496356", "url": "https://glygen.org/publication/PubMed/22496356", "database": "PubMed", "categories": [ "Other" ] }, { "id": "22768106", "url": "https://glygen.org/publication/PubMed/22768106", "database": "PubMed", "categories": [ "Other" ] }, { "id": "24126052", "url": "https://glygen.org/publication/PubMed/24126052", "database": "PubMed", "categories": [ "Other" ] }, { "id": "24136149", "url": "https://glygen.org/publication/PubMed/24136149", "database": "PubMed", "categories": [ "Other" ] }, { "id": "24469056", "url": "https://glygen.org/publication/PubMed/24469056", "database": "PubMed", "categories": [ "Other" ] }, { "id": "24516381", "url": "https://glygen.org/publication/PubMed/24516381", "database": "PubMed", "categories": [ "Other" ] }, { "id": "24589236", "url": "https://glygen.org/publication/PubMed/24589236", "database": "PubMed", "categories": [ "Other" ] }, { "id": "24763051", "url": "https://glygen.org/publication/PubMed/24763051", "database": "PubMed", "categories": [ "Other" ] }, { "id": "24954509", "url": "https://glygen.org/publication/PubMed/24954509", "database": "PubMed", "categories": [ "Other" ] }, { "id": "25199534", "url": "https://glygen.org/publication/PubMed/25199534", "database": "PubMed", "categories": [ "Other" ] }, { "id": "25406061", "url": "https://glygen.org/publication/PubMed/25406061", "database": "PubMed", "categories": [ "Other" ] }, { "id": "25728673", "url": "https://glygen.org/publication/PubMed/25728673", "database": "PubMed", "categories": [ "Other" ] }, { "id": "25811962", "url": "https://glygen.org/publication/PubMed/25811962", "database": "PubMed", "categories": [ "Other" ] }, { "id": "26010766", "url": "https://glygen.org/publication/PubMed/26010766", "database": "PubMed", "categories": [ "Other" ] }, { "id": "26018731", "url": "https://glygen.org/publication/PubMed/26018731", "database": "PubMed", "categories": [ "Other" ] }, { "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27043084", "url": "https://glygen.org/publication/PubMed/27043084", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27105490", "url": "https://glygen.org/publication/PubMed/27105490", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27639166", "url": "https://glygen.org/publication/PubMed/27639166", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27791982", "url": "https://glygen.org/publication/PubMed/27791982", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27997575", "url": "https://glygen.org/publication/PubMed/27997575", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28381880", "url": "https://glygen.org/publication/PubMed/28381880", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28415561", "url": "https://glygen.org/publication/PubMed/28415561", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28542269", "url": "https://glygen.org/publication/PubMed/28542269", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28618124", "url": "https://glygen.org/publication/PubMed/28618124", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29059166", "url": "https://glygen.org/publication/PubMed/29059166", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29088759", "url": "https://glygen.org/publication/PubMed/29088759", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29247221", "url": "https://glygen.org/publication/PubMed/29247221", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29296831", "url": "https://glygen.org/publication/PubMed/29296831", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29316077", "url": "https://glygen.org/publication/PubMed/29316077", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29606348", "url": "https://glygen.org/publication/PubMed/29606348", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29799521", "url": "https://glygen.org/publication/PubMed/29799521", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30038221", "url": "https://glygen.org/publication/PubMed/30038221", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30138434", "url": "https://glygen.org/publication/PubMed/30138434", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31109102", "url": "https://glygen.org/publication/PubMed/31109102", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31614463", "url": "https://glygen.org/publication/PubMed/31614463", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32302062", "url": "https://glygen.org/publication/PubMed/32302062", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32448393", "url": "https://glygen.org/publication/PubMed/32448393", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32457290", "url": "https://glygen.org/publication/PubMed/32457290", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32959058", "url": "https://glygen.org/publication/PubMed/32959058", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33407730", "url": "https://glygen.org/publication/PubMed/33407730", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35080342", "url": "https://glygen.org/publication/PubMed/35080342", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35959699", "url": "https://glygen.org/publication/PubMed/35959699", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "QSPRVEEASPGRPSSVDTLL", "down_seq": "PTALIDSILRESEPAPASVT", "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "No phosphorylation. Increased nuclear localization upon heat shock. No effect on oligomerization, DNA-binding activities and nuclear localization. Significant decrease in transcriptional activity by heat shock. Decreases transcriptional activity in a DAXX-dependent manner. Does not change interaction with XRCC5 and XRCC6. Weak decreased PLK1-induced phosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "15016915", "url": "https://glygen.org/publication/PubMed/15016915" }, { "database": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" }, { "database": "PubMed", "id": "26359349", "url": "https://glygen.org/publication/PubMed/26359349" }, { "database": "PubMed", "id": "15661742", "url": "https://glygen.org/publication/PubMed/15661742" }, { "database": "PubMed", "id": "27354066", "url": "https://glygen.org/publication/PubMed/27354066" } ] }, { "sequence_org": "S", "sequence_mut": "E", "comment": "Does not change interaction with XRCC5 and XRCC6.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "26359349", "url": "https://glygen.org/publication/PubMed/26359349" } ] } ], "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by MAPK12", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "15016915", "url": "https://glygen.org/publication/PubMed/15016915" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" }, { "database": "PubMed", "id": "21085490", "url": "https://glygen.org/publication/PubMed/21085490" }, { "database": "PubMed", "id": "22496356", "url": "https://glygen.org/publication/PubMed/22496356" }, { "database": "PubMed", "id": "22768106", "url": "https://glygen.org/publication/PubMed/22768106" }, { "database": "PubMed", "id": "24126052", "url": "https://glygen.org/publication/PubMed/24126052" }, { "database": "PubMed", "id": "24136149", "url": "https://glygen.org/publication/PubMed/24136149" }, { "database": "PubMed", "id": "24469056", "url": "https://glygen.org/publication/PubMed/24469056" }, { "database": "PubMed", "id": "24516381", "url": "https://glygen.org/publication/PubMed/24516381" }, { "database": "PubMed", "id": "24589236", "url": "https://glygen.org/publication/PubMed/24589236" }, { "database": "PubMed", "id": "24763051", "url": "https://glygen.org/publication/PubMed/24763051" }, { "database": "PubMed", "id": "24954509", "url": "https://glygen.org/publication/PubMed/24954509" }, { "database": "PubMed", "id": "25199534", "url": "https://glygen.org/publication/PubMed/25199534" }, { "database": "PubMed", "id": "25406061", "url": "https://glygen.org/publication/PubMed/25406061" }, { "database": "PubMed", "id": "25728673", "url": "https://glygen.org/publication/PubMed/25728673" }, { "database": "PubMed", "id": "25811962", "url": "https://glygen.org/publication/PubMed/25811962" }, { "database": "PubMed", "id": "26010766", "url": "https://glygen.org/publication/PubMed/26010766" }, { "database": "PubMed", "id": "26018731", "url": "https://glygen.org/publication/PubMed/26018731" }, { "database": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" }, { "database": "PubMed", "id": "27043084", "url": "https://glygen.org/publication/PubMed/27043084" }, { "database": "PubMed", "id": "27105490", "url": "https://glygen.org/publication/PubMed/27105490" }, { "database": "PubMed", "id": "27354066", "url": "https://glygen.org/publication/PubMed/27354066" }, { "database": "PubMed", "id": "27639166", "url": "https://glygen.org/publication/PubMed/27639166" }, { "database": "PubMed", "id": "27791982", "url": "https://glygen.org/publication/PubMed/27791982" }, { "database": "PubMed", "id": "27997575", "url": "https://glygen.org/publication/PubMed/27997575" }, { "database": "PubMed", "id": "28381880", "url": "https://glygen.org/publication/PubMed/28381880" }, { "database": "PubMed", "id": "28415561", "url": "https://glygen.org/publication/PubMed/28415561" }, { "database": "PubMed", "id": "28542269", "url": "https://glygen.org/publication/PubMed/28542269" }, { "database": "PubMed", "id": "28618124", "url": "https://glygen.org/publication/PubMed/28618124" }, { "database": "PubMed", "id": "29059166", "url": "https://glygen.org/publication/PubMed/29059166" }, { "database": "PubMed", "id": "29088759", "url": "https://glygen.org/publication/PubMed/29088759" }, { "database": "PubMed", "id": "29247221", "url": "https://glygen.org/publication/PubMed/29247221" }, { "database": "PubMed", "id": "29296831", "url": "https://glygen.org/publication/PubMed/29296831" }, { "database": "PubMed", "id": "29316077", "url": "https://glygen.org/publication/PubMed/29316077" }, { "database": "PubMed", "id": "29606348", "url": "https://glygen.org/publication/PubMed/29606348" }, { "database": "PubMed", "id": "29799521", "url": "https://glygen.org/publication/PubMed/29799521" }, { "database": "PubMed", "id": "30038221", "url": "https://glygen.org/publication/PubMed/30038221" }, { "database": "PubMed", "id": "30138434", "url": "https://glygen.org/publication/PubMed/30138434" }, { "database": "PubMed", "id": "31109102", "url": "https://glygen.org/publication/PubMed/31109102" }, { "database": "PubMed", "id": "31614463", "url": "https://glygen.org/publication/PubMed/31614463" }, { "database": "PubMed", "id": "32302062", "url": "https://glygen.org/publication/PubMed/32302062" }, { "database": "PubMed", "id": "32448393", "url": "https://glygen.org/publication/PubMed/32448393" }, { "database": "PubMed", "id": "32457290", "url": "https://glygen.org/publication/PubMed/32457290" }, { "database": "PubMed", "id": "32959058", "url": "https://glygen.org/publication/PubMed/32959058" }, { "database": "PubMed", "id": "33407730", "url": "https://glygen.org/publication/PubMed/33407730" }, { "database": "PubMed", "id": "35080342", "url": "https://glygen.org/publication/PubMed/35080342" }, { "database": "PubMed", "id": "35959699", "url": "https://glygen.org/publication/PubMed/35959699" }, { "database": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" } ], "site_lbl": "Ser326" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag", "phosphorylation_flag" ], "glycosylation": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "Q00613-1.307.307", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 17, "direction": "downstream", "id": "Q00613-1.309.309", "categories": [ "mutagenesis_flag" ] }, { "distance": 15, "direction": "downstream", "id": "Q00613-1.311.311", "categories": [ "mutagenesis_flag" ] }, { "distance": 12, "direction": "downstream", "id": "Q00613-1.314.314", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 7, "direction": "downstream", "id": "Q00613-1.319.319", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 6, "direction": "downstream", "id": "Q00613-1.320.320", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q00613-1.323.323", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 18, "direction": "upstream", "id": "Q00613-1.344.344", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 52 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.363.363", "start_pos": 363, "end_pos": 363, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Hietakangas V, Ahlskog JK, Jakobsson AM, Hellesuo M, Sahlberg NM, Holmberg CI, Mikhailov A, Palvimo JJ, Pirkkala L, Sistonen L", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" } ] }, { "title": "c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Dai R, Frejtag W, He B, Zhang Y, Mivechi NF", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "10747973", "url": "https://glygen.org/publication/PubMed/10747973" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Successive and selective release of phosphorylated peptides captured by hydroxy acid-modified metal oxide chromatography.", "journal": "Journal of proteome research", "date": "2008", "authors": "Kyono Y, Sugiyama N, Imami K, Tomita M, Ishihama Y", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "18767875", "url": "https://glygen.org/publication/PubMed/18767875" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis.", "journal": "Electrophoresis", "date": "2010", "authors": "Han G, Ye M, Liu H, Song C, Sun D, Wu Y, Jiang X, Chen R, Wang C, Wang L, Zou H", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ] }, { "title": "Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress.", "journal": "BMC biochemistry", "date": "2005", "authors": "Guettouche T, Boellmann F, Lane WS, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371571", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371571" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" } ] }, { "title": "Vitexin confers HSF-1 mediated autophagic cell death by activating JNK and ApoL1 in colorectal carcinoma cells.", "journal": "Oncotarget", "date": "2017", "authors": "Bhardwaj M, Paul S, Jakhar R, Khan I, Kang JI, Kim HM, Yun JW, Lee SJ, Cho HJ, Lee HG, Kang SC", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "29348836", "url": "https://glygen.org/publication/PubMed/29348836" } ] }, { "title": "Pan-Cancer Analysis of the Prognostic and Immunological Role of HSF1: A Potential Target for Survival and Immunotherapy.", "journal": "Oxidative medicine and cellular longevity", "date": "2021", "authors": "Chen F, Fan Y, Cao P, Liu B, Hou J, Zhang B, Tan K", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "34239690", "url": "https://glygen.org/publication/PubMed/34239690" } ] }, { "title": "Transcriptional activity of heat shock factor 1 at 37 degrees C is repressed through phosphorylation on two distinct serine residues by glycogen synthase kinase 3 and protein kinases Calpha and Czeta.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Chu B, Zhong R, Soncin F, Stevenson MA, Calderwood SK", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "9660838", "url": "https://glygen.org/publication/PubMed/9660838" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592", "database": "PubMed", "categories": [ "Other" ] }, { "id": "10747973", "url": "https://glygen.org/publication/PubMed/10747973", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648", "database": "PubMed", "categories": [ "Other" ] }, { "id": "18767875", "url": "https://glygen.org/publication/PubMed/18767875", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622", "database": "PubMed", "categories": [ "Other" ] }, { "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231", "database": "PubMed", "categories": [ "Other" ] }, { "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139", "database": "PubMed", "categories": [ "Other" ] }, { "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29348836", "url": "https://glygen.org/publication/PubMed/29348836", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34239690", "url": "https://glygen.org/publication/PubMed/34239690", "database": "PubMed", "categories": [ "Other" ] }, { "id": "9660838", "url": "https://glygen.org/publication/PubMed/9660838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163", "database": "PubMed", "categories": [ "Other" ] }, { "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "ASVTALTDARGHTDTEGRPP", "down_seq": "PPPTSTPEKCLSVACLDKNE", "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "Decreases MAPK8-induced phosphorylation and does not negatively regulates transactivating activity upon heat shock. No effect on sumoylation.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" }, { "database": "PubMed", "id": "10747973", "url": "https://glygen.org/publication/PubMed/10747973" } ] } ], "phosphorylation": [ { "kinase_uniprot_canonical_ac": "P45983-1", "kinase_gene_name": "MAPK8", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "10747973", "url": "https://glygen.org/publication/PubMed/10747973" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "18767875", "url": "https://glygen.org/publication/PubMed/18767875" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ], "site_lbl": "Ser363" }, { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by MAPK8", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "10747973", "url": "https://glygen.org/publication/PubMed/10747973" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "18767875", "url": "https://glygen.org/publication/PubMed/18767875" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" }, { "database": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" }, { "database": "PubMed", "id": "29348836", "url": "https://glygen.org/publication/PubMed/29348836" }, { "database": "PubMed", "id": "34239690", "url": "https://glygen.org/publication/PubMed/34239690" }, { "database": "PubMed", "id": "9660838", "url": "https://glygen.org/publication/PubMed/9660838" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ], "site_lbl": "Ser363" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag", "phosphorylation_flag" ], "glycosylation": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "Q00613-1.344.344", "categories": [ "phosphorylation_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q00613-1.367.367", "categories": [ "mutagenesis_flag", "snv_flag", "phosphorylation_flag" ] }, { "distance": 5, "direction": "upstream", "id": "Q00613-1.368.368", "categories": [ "phosphorylation_flag" ] }, { "distance": 6, "direction": "upstream", "id": "Q00613-1.369.369", "categories": [ "phosphorylation_flag" ] }, { "distance": 18, "direction": "upstream", "id": "Q00613-1.381.381", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 13 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.367.367", "start_pos": 367, "end_pos": 367, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.", "journal": "Scientific reports", "date": "2016", "authors": "Asano Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Tatebe S, Kitabayashi I, Tashiro F, Namiki H, Kondo T, Semba K, Aburatani H, Taya Y, Nakagama H, Ohki R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925", "database": "PubMed", "categories": [ "Other" ] }, { "id": "rs1554845037", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1554845037", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1554845037", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1554845037", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622", "database": "PubMed", "categories": [ "Other" ] }, { "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ALTDARGHTDTEGRPPSPPP", "down_seq": "STPEKCLSVACLDKNELSDH", "mutagenesis": [ { "sequence_org": "T", "sequence_mut": "D", "comment": "Decreased HSF1-induced expression of HSPA1A mRNA in a IER5-dependent manner; when associated with D-121; D-307; D-314 and D-323.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" } ] } ], "snv": [ { "evidence": [ { "id": "rs1554845037", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1554845037" }, { "id": "rs1554845037", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1554845037" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (TST->NST).", "chr_id": "8", "chr_pos": "144312202", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T367", "keywords": [ "ebi", "germline" ] } ], "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "26754925", "url": "https://glygen.org/publication/PubMed/26754925" } ], "site_lbl": "Thr367" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag", "snv_flag", "phosphorylation_flag" ], "glycosylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "downstream", "id": "Q00613-1.363.363", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 1, "direction": "upstream", "id": "Q00613-1.368.368", "categories": [ "phosphorylation_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q00613-1.369.369", "categories": [ "phosphorylation_flag" ] }, { "distance": 14, "direction": "upstream", "id": "Q00613-1.381.381", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": true, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.381.381", "start_pos": 381, "end_pos": 381, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Hietakangas V, Ahlskog JK, Jakobsson AM, Hellesuo M, Sahlberg NM, Holmberg CI, Mikhailov A, Palvimo JJ, Pirkkala L, Sistonen L", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "PPSPPPTSTPEKCLSVACLD", "down_seq": "NELSDHLDAMDSNLDNLQTM", "mutagenesis": [ { "sequence_org": "K", "sequence_mut": "R", "comment": "No effect on sumoylation.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 18, "direction": "downstream", "id": "Q00613-1.363.363", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 14, "direction": "downstream", "id": "Q00613-1.367.367", "categories": [ "mutagenesis_flag", "snv_flag", "phosphorylation_flag" ] }, { "distance": 13, "direction": "downstream", "id": "Q00613-1.368.368", "categories": [ "phosphorylation_flag" ] }, { "distance": 12, "direction": "downstream", "id": "Q00613-1.369.369", "categories": [ "phosphorylation_flag" ] }, { "distance": 10, "direction": "upstream", "id": "Q00613-1.391.391", "categories": [ "mutagenesis_flag" ] }, { "distance": 14, "direction": "upstream", "id": "Q00613-1.395.395", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.391.391", "start_pos": 391, "end_pos": 391, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Activation of the DNA-binding ability of human heat shock transcription factor 1 may involve the transition from an intramolecular to an intermolecular triple-stranded coiled-coil structure.", "journal": "Molecular and cellular biology", "date": "1994", "authors": "Zuo J, Baler R, Dahl G, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "reference": [ { "type": "PubMed", "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471" } ] }, { "title": "Multiple layers of regulation of human heat shock transcription factor 1.", "journal": "Molecular and cellular biology", "date": "1995", "authors": "Zuo J, Rungger D, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "reference": [ { "type": "PubMed", "id": "7623826", "url": "https://glygen.org/publication/PubMed/7623826" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471", "database": "PubMed", "categories": [ "Other" ] }, { "id": "7623826", "url": "https://glygen.org/publication/PubMed/7623826", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "M", "start_aa": "M", "up_seq": "EKCLSVACLDKNELSDHLDA", "down_seq": "DSNLDNLQTMLSSHGFSVDT", "mutagenesis": [ { "sequence_org": "M", "sequence_mut": "A", "comment": "Does not lead to constitutive DNA-binding activity at 20 degrees Celsius. Leads to weak constitutive DNA-binding and homotrimerization activities at 30 degrees Celsius. Decreased DNA-binding activity at 37 degrees Celsius.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471" } ] }, { "sequence_org": "M", "sequence_mut": "E", "comment": "Leads to constitutive DNA-binding and homotrimerization activities at 20 degrees Celsius. Does not lead to constitutive transactivation activity at 20 degrees Celsius. No effect on DNA-binding activity at 37 degrees Celsius.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "7623826", "url": "https://glygen.org/publication/PubMed/7623826" }, { "database": "PubMed", "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471" } ] }, { "sequence_org": "M", "sequence_mut": "K", "comment": "Leads to constitutive DNA-binding and homotrimerization activities at 20 degrees Celsius. No effect on DNA-binding activity at 37 degrees Celsius.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 10, "direction": "downstream", "id": "Q00613-1.381.381", "categories": [ "mutagenesis_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q00613-1.395.395", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.395.395", "start_pos": 395, "end_pos": 395, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Activation of the DNA-binding ability of human heat shock transcription factor 1 may involve the transition from an intramolecular to an intermolecular triple-stranded coiled-coil structure.", "journal": "Molecular and cellular biology", "date": "1994", "authors": "Zuo J, Baler R, Dahl G, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "reference": [ { "type": "PubMed", "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "L", "start_aa": "L", "up_seq": "SVACLDKNELSDHLDAMDSN", "down_seq": "DNLQTMLSSHGFSVDTSALL", "mutagenesis": [ { "sequence_org": "L", "sequence_mut": "E", "comment": "Leads to constitutive DNA-binding and homotrimerization activities at 20 degrees Celsius. No effect on DNA-binding activity at 37 degrees Celsius.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471" } ] }, { "sequence_org": "L", "sequence_mut": "K", "comment": "Leads to constitutive DNA-binding and homotrimerization activities at 20 degrees Celsius. No effect on DNA-binding activity at 37 degrees Celsius.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "7935471", "url": "https://glygen.org/publication/PubMed/7935471" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 14, "direction": "downstream", "id": "Q00613-1.381.381", "categories": [ "mutagenesis_flag" ] }, { "distance": 4, "direction": "downstream", "id": "Q00613-1.391.391", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.419.419", "start_pos": 419, "end_pos": 419, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Heat shock factor 1, an inhibitor of non-homologous end joining repair.", "journal": "Oncotarget", "date": "2015", "authors": "Kang GY, Kim EH, Lee HJ, Gil NY, Cha HJ, Lee YS", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "reference": [ { "type": "PubMed", "id": "26359349", "url": "https://glygen.org/publication/PubMed/26359349" } ] }, { "title": "Polo-like kinase 1 phosphorylates heat shock transcription factor 1 and mediates its nuclear translocation during heat stress.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Kim SA, Yoon JH, Lee SH, Ahn SG", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "15661742", "url": "https://glygen.org/publication/PubMed/15661742" } ] }, { "title": "HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression.", "journal": "Cancer research", "date": "2008", "authors": "Lee YJ, Kim EH, Lee JS, Jeoung D, Bae S, Kwon SH, Lee YS", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "18794143", "url": "https://glygen.org/publication/PubMed/18794143" } ] }, { "title": "Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress.", "journal": "BMC biochemistry", "date": "2005", "authors": "Guettouche T, Boellmann F, Lane WS, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371571", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371571" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" } ] }, { "title": "Decreased expression of FBXW7 by ERK1/2 activation in drug-resistant cancer cells confers transcriptional activation of MDR1 by suppression of ubiquitin degradation of HSF1.", "journal": "Cell death & disease", "date": "2020", "authors": "Mun GI, Choi E, Lee Y, Lee YS", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "32457290", "url": "https://glygen.org/publication/PubMed/32457290" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "26359349", "url": "https://glygen.org/publication/PubMed/26359349", "database": "PubMed", "categories": [ "Other" ] }, { "id": "15661742", "url": "https://glygen.org/publication/PubMed/15661742", "database": "PubMed", "categories": [ "Other" ] }, { "id": "18794143", "url": "https://glygen.org/publication/PubMed/18794143", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32457290", "url": "https://glygen.org/publication/PubMed/32457290", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "QTMLSSHGFSVDTSALLDLF", "down_seq": "PSVTVPDMSLPDLDSSLASI", "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "Does not change interaction with XRCC5 and XRCC6. Decreased nuclear localization upon heat shock. Strongly decreases PLK1-induced phosphorylation. No change in PLK1-induced phosphorylation in mitosis.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "26359349", "url": "https://glygen.org/publication/PubMed/26359349" }, { "database": "PubMed", "id": "15661742", "url": "https://glygen.org/publication/PubMed/15661742" }, { "database": "PubMed", "id": "18794143", "url": "https://glygen.org/publication/PubMed/18794143" } ] }, { "sequence_org": "S", "sequence_mut": "E", "comment": "Does not change interaction with XRCC5 and XRCC6.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "26359349", "url": "https://glygen.org/publication/PubMed/26359349" } ] } ], "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PLK1", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "15661742", "url": "https://glygen.org/publication/PubMed/15661742" }, { "database": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" }, { "database": "PubMed", "id": "32457290", "url": "https://glygen.org/publication/PubMed/32457290" } ], "site_lbl": "Ser419" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag", "phosphorylation_flag" ], "glycosylation": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 14, "direction": "upstream", "id": "Q00613-1.433.433", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.527.527", "start_pos": 527, "end_pos": 527, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Wang X, Khaleque MA, Zhao MJ, Zhong R, Gaestel M, Calderwood SK", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371453" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "16278218", "url": "https://glygen.org/publication/PubMed/16278218" } ] }, { "title": "AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation.", "journal": "The FEBS journal", "date": "2022-07", "authors": "Lu Wen-Cheng, Omari Ramsey, Ray Haimanti, Wang John, Williams Imade, Jacobs Curteisha, Hockaden Natasha, Bochman Matthew L, Carpenter Richard L", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "35080342", "url": "https://glygen.org/publication/PubMed/35080342" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "16278218", "url": "https://glygen.org/publication/PubMed/16278218", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "35080342", "url": "https://glygen.org/publication/PubMed/35080342", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "AEDPTISLLTGSEPPKAKDP", "down_seq": "VS", "mutagenesis": [ { "sequence_org": "T", "sequence_mut": "A", "comment": "No change in binding HSE nor on transcriptional activity. Decreased binding HSE; when associated with A-529.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "16278218", "url": "https://glygen.org/publication/PubMed/16278218" } ] } ], "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "35080342", "url": "https://glygen.org/publication/PubMed/35080342" } ], "site_lbl": "Thr527" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag", "phosphorylation_flag" ], "glycosylation": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "upstream", "id": "Q00613-1.529.529", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.529.529", "start_pos": 529, "end_pos": 529, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Wang X, Khaleque MA, Zhao MJ, Zhong R, Gaestel M, Calderwood SK", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371453" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "16278218", "url": "https://glygen.org/publication/PubMed/16278218" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "16278218", "url": "https://glygen.org/publication/PubMed/16278218", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "DPTISLLTGSEPPKAKDPTV", "down_seq": "", "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "No change in binding HSE nor on transcriptional activity. Decreased binding HSE; when associated with A-527.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "16278218", "url": "https://glygen.org/publication/PubMed/16278218" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "downstream", "id": "Q00613-1.527.527", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.80.80", "start_pos": 80, "end_pos": 80, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Interplay of acetyltransferase EP300 and the proteasome system in regulating heat shock transcription factor 1.", "journal": "Cell", "date": "2014", "authors": "Raychaudhuri S, Loew C, Korner R, Pinkert S, Theis M, Hayer-Hartl M, Buchholz F, Hartl FU", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "reference": [ { "type": "PubMed", "id": "24581496", "url": "https://glygen.org/publication/PubMed/24581496" } ] }, { "title": "Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1.", "journal": "Science (New York, N.Y.)", "date": "2009", "authors": "Westerheide SD, Anckar J, Stevens SM Jr, Sistonen L, Morimoto RI", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371453" } ], "reference": [ { "type": "PubMed", "id": "19229036", "url": "https://glygen.org/publication/PubMed/19229036" } ] }, { "title": "Heat shock factor 1, an inhibitor of non-homologous end joining repair.", "journal": "Oncotarget", "date": "2015", "authors": "Kang GY, Kim EH, Lee HJ, Gil NY, Cha HJ, Lee YS", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "reference": [ { "type": "PubMed", "id": "26359349", "url": "https://glygen.org/publication/PubMed/26359349" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "24581496", "url": "https://glygen.org/publication/PubMed/24581496", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19229036", "url": "https://glygen.org/publication/PubMed/19229036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "26359349", "url": "https://glygen.org/publication/PubMed/26359349", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "YFKHNNMASFVRQLNMYGFR", "down_seq": "VVHIEQGGLVKPERDDTEFQ", "mutagenesis": [ { "sequence_org": "K", "sequence_mut": "Q", "comment": "Loss of nuclear stress bodies localization. Loss of DNA-binding and transcriptional activities upon heat shock. No change in homotrimerization upon heat shock.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "24581496", "url": "https://glygen.org/publication/PubMed/24581496" }, { "database": "PubMed", "id": "19229036", "url": "https://glygen.org/publication/PubMed/19229036" } ] }, { "sequence_org": "K", "sequence_mut": "R", "comment": "Does not change interaction with XRCC5 and XRCC6. Loss of nuclear stress bodies localization. Decreased nuclear stress bodies localization. Loss of DNA-binding and transcriptional activities upon heat shock.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "24581496", "url": "https://glygen.org/publication/PubMed/24581496" }, { "database": "PubMed", "id": "26359349", "url": "https://glygen.org/publication/PubMed/26359349" }, { "database": "PubMed", "id": "19229036", "url": "https://glygen.org/publication/PubMed/19229036" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 11, "direction": "upstream", "id": "Q00613-1.91.91", "categories": [ "mutagenesis_flag" ] }, { "distance": 15, "direction": "upstream", "id": "Q00613-1.95.95", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.91.91", "start_pos": 91, "end_pos": 91, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Hietakangas V, Ahlskog JK, Jakobsson AM, Hellesuo M, Sahlberg NM, Holmberg CI, Mikhailov A, Palvimo JJ, Pirkkala L, Sistonen L", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "RQLNMYGFRKVVHIEQGGLV", "down_seq": "PERDDTEFQHPCFLRGQEQL", "mutagenesis": [ { "sequence_org": "K", "sequence_mut": "R", "comment": "No effect on sumoylation.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "12665592", "url": "https://glygen.org/publication/PubMed/12665592" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 11, "direction": "downstream", "id": "Q00613-1.80.80", "categories": [ "mutagenesis_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q00613-1.95.95", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.167.167", "start_pos": 167, "end_pos": 167, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q00613", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q00613", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs1816621189", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1816621189", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1816621189", "url": "https://www.ensembl.org/id/rs1816621189", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "A", "start_aa": "A", "up_seq": "MKGKQECMDSKLLAMKHENE", "down_seq": "LWREVASLRQKHAQQQKVVN", "snv": [ { "evidence": [ { "id": "Q00613", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q00613" }, { "id": "rs1816621189", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1816621189" }, { "id": "rs1816621189", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1816621189" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "subjects_tested": "2670", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "A", "sequence_mut": "T", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (NEA->NET).", "chr_id": "8", "chr_pos": "144311184", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "A167", "disease": [ { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ], "unlinked_id_list": [ "DOID:4203", "DOID:3541", "DOID:4706", "DOID:1659", "DOID:368" ], "evidence": [ { "id": "1319", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1319" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 20, "direction": "downstream", "id": "Q00613-1.147.147", "categories": [ "mutagenesis_flag" ] }, { "distance": 17, "direction": "downstream", "id": "Q00613-1.150.150", "categories": [ "mutagenesis_flag" ] }, { "distance": 5, "direction": "downstream", "id": "Q00613-1.162.162", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q00613-1.16.16", "start_pos": 16, "end_pos": 16, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1554840396", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1554840396", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1554840396", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1554840396#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs1554840396", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1554840396", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "P", "start_aa": "P", "up_seq": "MDLPVGPGAAGPSNV", "down_seq": "AFLTKLWTLVSDPDTDALIC", "snv": [ { "evidence": [ { "id": "rs1554840396", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1554840396" }, { "id": "rs1554840396", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1554840396#frequency_tab" }, { "id": "rs1554840396", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1554840396" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "P", "sequence_mut": "S", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (NVP->NVS).", "chr_id": "8", "chr_pos": "144291803", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P16", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 16, "direction": "downstream", "id": "Q00613-1.0.0", "categories": [ "glycosylation_flag" ] }, { "distance": 6, "direction": "upstream", "id": "Q00613-1.22.22", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q00613-1.190.190", "start_pos": 190, "end_pos": 190, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q00613", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q00613", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "I", "start_aa": "I", "up_seq": "REVASLRQKHAQQQKVVNKL", "down_seq": "QFLISLVQSNRILGVKRKIP", "snv": [ { "evidence": [ { "id": "Q00613", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q00613" } ], "glycoeffect": [], "subjects_tested": "92", "subjects_positive": "1", "frequency": "1.1", "sequence_org": "I", "sequence_mut": "N", "comment": "Somatic mutation passed 1 filters: patient freq. (1.1%).", "chr_id": "8", "chr_pos": "144311325", "ref_nt": "T", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "I190", "keywords": [ "biomuta", "somatic", "cancer" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 1, "direction": "downstream", "id": "Q00613-1.189.189", "categories": [ "mutagenesis_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q00613-1.193.193", "categories": [ "mutagenesis_flag" ] }, { "distance": 18, "direction": "upstream", "id": "Q00613-1.208.208", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q00613-1.254.254", "start_pos": 254, "end_pos": 254, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q00613", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q00613", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "A", "start_aa": "A", "up_seq": "VHGSGPYSAPSPAYSSSSLY", "down_seq": "PDAVASSGPIISDITELAPA", "snv": [ { "evidence": [ { "id": "Q00613", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q00613" } ], "glycoeffect": [], "subjects_tested": "720", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "A", "sequence_mut": "T", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "8", "chr_pos": "144311736", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "A254", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3675", "DOID:4455" ], "evidence": [ { "id": "263", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:263" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 13, "direction": "upstream", "id": "Q00613-1.267.267", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q00613-1.267.267", "start_pos": 267, "end_pos": 267, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1554844650", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1554844650", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1554844650", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1554844650", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "YSSSSLYAPDAVASSGPIIS", "down_seq": "ITELAPASPMASPGGSIDER", "snv": [ { "evidence": [ { "id": "rs1554844650", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1554844650" }, { "id": "rs1554844650", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1554844650" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (DIT->NIT).", "chr_id": "8", "chr_pos": "144311775", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D267", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 13, "direction": "downstream", "id": "Q00613-1.254.254", "categories": [ "snv_flag" ] }, { "distance": 8, "direction": "upstream", "id": "Q00613-1.275.275", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q00613-1.433.433", "start_pos": 433, "end_pos": 433, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs781926454", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs781926454", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs781926454", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs781926454", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs781926454", "url": "http://gnomad.broadinstitute.org/awesome?query=rs781926454", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "ALLDLFSPSVTVPDMSLPDL", "down_seq": "SSLASIQELLSPQEPPRPPE", "snv": [ { "evidence": [ { "id": "rs781926454", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs781926454" }, { "id": "rs781926454", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs781926454" }, { "id": "rs781926454", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs781926454" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (DSS->NSS).", "chr_id": "8", "chr_pos": "144313894", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D433", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 14, "direction": "downstream", "id": "Q00613-1.419.419", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 11, "direction": "upstream", "id": "Q00613-1.444.444", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q00613-1.95.95", "start_pos": 95, "end_pos": 95, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q00613", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q00613", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "MYGFRKVVHIEQGGLVKPER", "down_seq": "DTEFQHPCFLRGQEQLLENI", "snv": [ { "evidence": [ { "id": "Q00613", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q00613" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "subjects_tested": "2670", "subjects_positive": "2", "frequency": "0.1", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (DDT->NDT).", "chr_id": "8", "chr_pos": "144309511", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "D95", "disease": [ { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ], "unlinked_id_list": [ "DOID:4203", "DOID:3541", "DOID:4706", "DOID:1659", "DOID:368" ], "evidence": [ { "id": "1319", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1319" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 15, "direction": "downstream", "id": "Q00613-1.80.80", "categories": [ "mutagenesis_flag" ] }, { "distance": 4, "direction": "downstream", "id": "Q00613-1.91.91", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q00613-1.127.127", "start_pos": 127, "end_pos": 127, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] } ], "crossref": [ { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "GQEQLLENIKRKVTSVSTLK", "down_seq": "EDIKIRQDSVTKLLTDVQLM", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser127" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 9, "direction": "downstream", "id": "Q00613-1.118.118", "categories": [ "mutagenesis_flag" ] }, { "distance": 7, "direction": "downstream", "id": "Q00613-1.120.120", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 6, "direction": "downstream", "id": "Q00613-1.121.121", "categories": [ "mutagenesis_flag", "snv_flag", "phosphorylation_flag" ] }, { "distance": 4, "direction": "downstream", "id": "Q00613-1.123.123", "categories": [ "glycosylation_flag", "mutagenesis_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q00613-1.124.124", "categories": [ "glycosylation_flag", "mutagenesis_flag", "snv_flag" ] }, { "distance": 1, "direction": "downstream", "id": "Q00613-1.126.126", "categories": [ "mutagenesis_flag" ] }, { "distance": 13, "direction": "upstream", "id": "Q00613-1.140.140", "categories": [ "mutagenesis_flag" ] }, { "distance": 15, "direction": "upstream", "id": "Q00613-1.142.142", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 20, "direction": "upstream", "id": "Q00613-1.147.147", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.344.344", "start_pos": 344, "end_pos": 344, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress.", "journal": "BMC biochemistry", "date": "2005", "authors": "Guettouche T, Boellmann F, Lane WS, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371571", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371571" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "LLSPTALIDSILRESEPAPA", "down_seq": "VTALTDARGHTDTEGRPPSP", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "site_lbl": "Ser344" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 18, "direction": "downstream", "id": "Q00613-1.326.326", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 19, "direction": "upstream", "id": "Q00613-1.363.363", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.368.368", "start_pos": 368, "end_pos": 368, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] } ], "crossref": [ { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622", "database": "PubMed", "categories": [ "Other" ] }, { "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "LTDARGHTDTEGRPPSPPPT", "down_seq": "TPEKCLSVACLDKNELSDHL", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser368" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 5, "direction": "downstream", "id": "Q00613-1.363.363", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 1, "direction": "downstream", "id": "Q00613-1.367.367", "categories": [ "mutagenesis_flag", "snv_flag", "phosphorylation_flag" ] }, { "distance": 1, "direction": "upstream", "id": "Q00613-1.369.369", "categories": [ "phosphorylation_flag" ] }, { "distance": 13, "direction": "upstream", "id": "Q00613-1.381.381", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.369.369", "start_pos": 369, "end_pos": 369, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications.", "journal": "Molecular & cellular proteomics : MCP", "date": "2007", "authors": "Sugiyama N, Masuda T, Shinoda K, Nakamura A, Tomita M, Ishihama Y", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "17322306", "url": "https://glygen.org/publication/PubMed/17322306" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis.", "journal": "Electrophoresis", "date": "2010", "authors": "Han G, Ye M, Liu H, Song C, Sun D, Wu Y, Jiang X, Chen R, Wang C, Wang L, Zou H", "evidence": [ { "database": "iPTMnet", "id": "Q00613-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613-1" } ], "reference": [ { "type": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ] } ], "crossref": [ { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "17322306", "url": "https://glygen.org/publication/PubMed/17322306", "database": "PubMed", "categories": [ "Other" ] }, { "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648", "database": "PubMed", "categories": [ "Other" ] }, { "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231", "database": "PubMed", "categories": [ "Other" ] }, { "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TDARGHTDTEGRPPSPPPTS", "down_seq": "PEKCLSVACLDKNELSDHLD", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" }, { "database": "PubMed", "id": "17322306", "url": "https://glygen.org/publication/PubMed/17322306" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ], "site_lbl": "Thr369" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 6, "direction": "downstream", "id": "Q00613-1.363.363", "categories": [ "mutagenesis_flag", "phosphorylation_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q00613-1.367.367", "categories": [ "mutagenesis_flag", "snv_flag", "phosphorylation_flag" ] }, { "distance": 1, "direction": "downstream", "id": "Q00613-1.368.368", "categories": [ "phosphorylation_flag" ] }, { "distance": 12, "direction": "upstream", "id": "Q00613-1.381.381", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00613-1.444.444", "start_pos": 444, "end_pos": 444, "uniprot_canonical_ac": "Q00613-1", "length": 529, "uniprot_id": "HSF1_HUMAN", "protein_name": "Heat shock factor protein 1", "refseq_ac": "NP_005517", "refseq_name": "heat shock factor protein 1", "gene_name": "HSF1", "gene_names_uniprotkb": "HSF1; HSTF1", "gene_names_refseq": "HSF1; HSTF1", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress.", "journal": "BMC biochemistry", "date": "2005", "authors": "Guettouche T, Boellmann F, Lane WS, Voellmy R", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "Reactome", "id": "R-HSA-3371571", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371571" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "reference": [ { "type": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" } ] } ], "crossref": [ { "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613", "database": "iPTMnet", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "VPDMSLPDLDSSLASIQELL", "down_seq": "PQEPPRPPEAENSSPDSGKQ", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "15760475", "url": "https://glygen.org/publication/PubMed/15760475" }, { "database": "iPTMnet", "id": "Q00613", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00613" } ], "site_lbl": "Ser444" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "214", "end_pos": "214" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "118", "end_pos": "118" }, { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "123", "end_pos": "123" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "126", "end_pos": "126" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "147", "end_pos": "147" }, { "start_pos": "150", "end_pos": "150" }, { "start_pos": "162", "end_pos": "162" }, { "start_pos": "189", "end_pos": "189" }, { "start_pos": "193", "end_pos": "193" }, { "start_pos": "208", "end_pos": "208" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "22", "end_pos": "22" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "296", "end_pos": "296" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "298", "end_pos": "298" }, { "start_pos": "299", "end_pos": "299" }, { "start_pos": "300", "end_pos": "300" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "309", "end_pos": "309" }, { "start_pos": "311", "end_pos": "311" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "381", "end_pos": "381" }, { "start_pos": "391", "end_pos": "391" }, { "start_pos": "395", "end_pos": "395" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "527", "end_pos": "527" }, { "start_pos": "529", "end_pos": "529" }, { "start_pos": "80", "end_pos": "80" }, { "start_pos": "91", "end_pos": "91" } ] }, { "type": "snv", "site_list": [ { "start_pos": "121", "end_pos": "121" }, { "start_pos": "124", "end_pos": "124" }, { "start_pos": "167", "end_pos": "167" }, { "start_pos": "16", "end_pos": "16" }, { "start_pos": "190", "end_pos": "190" }, { "start_pos": "214", "end_pos": "214" }, { "start_pos": "254", "end_pos": "254" }, { "start_pos": "267", "end_pos": "267" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "433", "end_pos": "433" }, { "start_pos": "95", "end_pos": "95" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "120", "end_pos": "120" }, { "start_pos": "121", "end_pos": "121" }, { "start_pos": "127", "end_pos": "127" }, { "start_pos": "142", "end_pos": "142" }, { "start_pos": "216", "end_pos": "216" }, { "start_pos": "230", "end_pos": "230" }, { "start_pos": "275", "end_pos": "275" }, { "start_pos": "292", "end_pos": "292" }, { "start_pos": "303", "end_pos": "303" }, { "start_pos": "307", "end_pos": "307" }, { "start_pos": "314", "end_pos": "314" }, { "start_pos": "319", "end_pos": "319" }, { "start_pos": "320", "end_pos": "320" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "326", "end_pos": "326" }, { "start_pos": "344", "end_pos": "344" }, { "start_pos": "363", "end_pos": "363" }, { "start_pos": "367", "end_pos": "367" }, { "start_pos": "368", "end_pos": "368" }, { "start_pos": "369", "end_pos": "369" }, { "start_pos": "419", "end_pos": "419" }, { "start_pos": "444", "end_pos": "444" }, { "start_pos": "527", "end_pos": "527" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 11, "direction": "downstream", "id": "Q00613-1.433.433", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q6UXL0-1.134.134", "start_pos": 134, "end_pos": 134, "uniprot_canonical_ac": "Q6UXL0-1", "length": 311, "uniprot_id": "I20RB_HUMAN", "protein_name": "Interleukin-20 receptor subunit beta", "refseq_ac": "NP_653318", "refseq_name": "interleukin-20 receptor subunit beta precursor", "gene_name": "IL20RB", "gene_names_uniprotkb": "IL20RB; DIRS1; PRO1114", "gene_names_refseq": "DIRS1; FNDC6; IL-20R-beta; IL-20R2; IL-20RB; IL20RB", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q6UXL0", "url": "https://www.uniprot.org/uniprotkb/Q6UXL0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Deep quantitative glycoproteomics reveals gut microbiome induced remodeling of the brain glycoproteome", "journal": "bioRxiv", "date": "2023", "authors": "Potel C.M., Burtscher M.L., Garrido-Rodriguez M., Brauer-Nikonow A., Becher I., Typas A., Zimmermann M., Savitski M.", "evidence": [ { "database": "Data Submission", "id": "GLY_000888", "url": "http://data.glygen.org/GLY_000888" } ], "reference": [ { "type": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" } ] } ], "crossref": [ { "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529", "database": "DOI", "categories": [ "Other" ] }, { "id": "GLY_000888", "url": "http://data.glygen.org/GLY_000888", "database": "Data Submission", "categories": [ "Other" ] }, { "id": "Q6UXL0", "url": "https://www.uniprot.org/uniprotkb/Q6UXL0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "rs1297595331", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1297595331", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1297595331", "url": "https://www.ensembl.org/id/rs1297595331", "database": "ENSEMBL", "categories": [ "Other" ] }, { "id": "Q6UXL0", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q6UXL0", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "RATLGSQTSAWSILKHPFNR", "down_seq": "STILTRPGMEITKDGFHLVI", "glycosylation": [ { "glytoucan_ac": "G27058EU", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "NSTILTR", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn134", "evidence": [ { "id": "10.1101/2023.09.13.557529", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "id": "GLY_000888", "database": "Data Submission", "url": "http://data.glygen.org/GLY_000888" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn134", "evidence": [ { "id": "Q6UXL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6UXL0#ptm_processing" } ] } ], "snv": [ { "evidence": [ { "id": "rs1297595331", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1297595331" }, { "id": "rs1297595331", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1297595331" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "N", "sequence_mut": "H", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NST->HST).", "chr_id": "3", "chr_pos": "136982344", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N134", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "Q6UXL0", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q6UXL0" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "subjects_tested": "3601", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "N", "sequence_mut": "K", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-loss (NST->KST).", "chr_id": "3", "chr_pos": "136982346", "ref_nt": "C", "alt_nt": "G", "minor_allelic_frequency": "", "site_lbl": "N134", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "134", "end_pos": "134" }, { "start_pos": "40", "end_pos": "40" } ] }, { "type": "snv", "site_list": [ { "start_pos": "112", "end_pos": "112" }, { "start_pos": "134", "end_pos": "134" }, { "start_pos": "136", "end_pos": "136" }, { "start_pos": "293", "end_pos": "293" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "40", "end_pos": "40" }, { "start_pos": "75", "end_pos": "75" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "upstream", "id": "Q6UXL0-1.136.136", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q6UXL0-1.40.40", "start_pos": 40, "end_pos": 40, "uniprot_canonical_ac": "Q6UXL0-1", "length": 311, "uniprot_id": "I20RB_HUMAN", "protein_name": "Interleukin-20 receptor subunit beta", "refseq_ac": "NP_653318", "refseq_name": "interleukin-20 receptor subunit beta precursor", "gene_name": "IL20RB", "gene_names_uniprotkb": "IL20RB; DIRS1; PRO1114", "gene_names_refseq": "DIRS1; FNDC6; IL-20R-beta; IL-20R2; IL-20RB; IL20RB", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q6UXL0", "url": "https://www.uniprot.org/uniprotkb/Q6UXL0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q6UXL0", "url": "https://www.uniprot.org/uniprotkb/Q6UXL0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "rs1941743406", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1941743406", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1941743406", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1941743406#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "FYALIPCLLTDEVAILPAPQ", "down_seq": "LSVLSTNMKHLLMWSPVIAP", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn40", "evidence": [ { "id": "Q6UXL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6UXL0#ptm_processing" } ] } ], "snv": [ { "evidence": [ { "id": "rs1941743406", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1941743406" }, { "id": "rs1941743406", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1941743406#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "N", "sequence_mut": "K", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NLS->KLS).", "chr_id": "3", "chr_pos": "136980497", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N40", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "134", "end_pos": "134" }, { "start_pos": "40", "end_pos": "40" } ] }, { "type": "snv", "site_list": [ { "start_pos": "112", "end_pos": "112" }, { "start_pos": "134", "end_pos": "134" }, { "start_pos": "136", "end_pos": "136" }, { "start_pos": "293", "end_pos": "293" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "40", "end_pos": "40" }, { "start_pos": "75", "end_pos": "75" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q6UXL0-1.112.112", "start_pos": 112, "end_pos": 112, "uniprot_canonical_ac": "Q6UXL0-1", "length": 311, "uniprot_id": "I20RB_HUMAN", "protein_name": "Interleukin-20 receptor subunit beta", "refseq_ac": "NP_653318", "refseq_name": "interleukin-20 receptor subunit beta precursor", "gene_name": "IL20RB", "gene_names_uniprotkb": "IL20RB; DIRS1; PRO1114", "gene_names_refseq": "DIRS1; FNDC6; IL-20R-beta; IL-20R2; IL-20RB; IL20RB", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q6UXL0", "url": "https://www.uniprot.org/uniprotkb/Q6UXL0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q6UXL0", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q6UXL0", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs752060952", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs752060952", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs752060952", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs752060952", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs752060952", "url": "https://www.ncbi.nlm.nih.gov/snp/rs752060952#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs752060952", "url": "http://gnomad.broadinstitute.org/awesome?query=rs752060952", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "TEGPECDVTDDITATVPYNL", "down_seq": "VRATLGSQTSAWSILKHPFN", "snv": [ { "evidence": [ { "id": "Q6UXL0", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q6UXL0" }, { "id": "rs752060952", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs752060952" }, { "id": "rs752060952", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs752060952" }, { "id": "rs752060952", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs752060952#frequency_tab" }, { "id": "rs752060952", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs752060952" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "subjects_tested": "2053", "subjects_positive": "3", "frequency": "0.1", "sequence_org": "R", "sequence_mut": "C", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (NLR->NLC).", "chr_id": "3", "chr_pos": "136982278", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "R112", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "134", "end_pos": "134" }, { "start_pos": "40", "end_pos": "40" } ] }, { "type": "snv", "site_list": [ { "start_pos": "112", "end_pos": "112" }, { "start_pos": "134", "end_pos": "134" }, { "start_pos": "136", "end_pos": "136" }, { "start_pos": "293", "end_pos": "293" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "40", "end_pos": "40" }, { "start_pos": "75", "end_pos": "75" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q6UXL0-1.136.136", "start_pos": 136, "end_pos": 136, "uniprot_canonical_ac": "Q6UXL0-1", "length": 311, "uniprot_id": "I20RB_HUMAN", "protein_name": "Interleukin-20 receptor subunit beta", "refseq_ac": "NP_653318", "refseq_name": "interleukin-20 receptor subunit beta precursor", "gene_name": "IL20RB", "gene_names_uniprotkb": "IL20RB; DIRS1; PRO1114", "gene_names_refseq": "DIRS1; FNDC6; IL-20R-beta; IL-20R2; IL-20RB; IL20RB", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q6UXL0", "url": "https://www.uniprot.org/uniprotkb/Q6UXL0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1264872213", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1264872213", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1264872213", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1264872213#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs1264872213", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1264872213", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "TLGSQTSAWSILKHPFNRNS", "down_seq": "ILTRPGMEITKDGFHLVIEL", "snv": [ { "evidence": [ { "id": "rs1264872213", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1264872213" }, { "id": "rs1264872213", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1264872213#frequency_tab" }, { "id": "rs1264872213", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1264872213" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NST->NSA).", "chr_id": "3", "chr_pos": "136982350", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T136", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "134", "end_pos": "134" }, { "start_pos": "40", "end_pos": "40" } ] }, { "type": "snv", "site_list": [ { "start_pos": "112", "end_pos": "112" }, { "start_pos": "134", "end_pos": "134" }, { "start_pos": "136", "end_pos": "136" }, { "start_pos": "293", "end_pos": "293" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "40", "end_pos": "40" }, { "start_pos": "75", "end_pos": "75" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "downstream", "id": "Q6UXL0-1.134.134", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q6UXL0-1.293.293", "start_pos": 293, "end_pos": 293, "uniprot_canonical_ac": "Q6UXL0-1", "length": 311, "uniprot_id": "I20RB_HUMAN", "protein_name": "Interleukin-20 receptor subunit beta", "refseq_ac": "NP_653318", "refseq_name": "interleukin-20 receptor subunit beta precursor", "gene_name": "IL20RB", "gene_names_uniprotkb": "IL20RB; DIRS1; PRO1114", "gene_names_refseq": "DIRS1; FNDC6; IL-20R-beta; IL-20R2; IL-20RB; IL20RB", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q6UXL0", "url": "https://www.uniprot.org/uniprotkb/Q6UXL0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q6UXL0", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q6UXL0", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "DTLKITNSPQKLISCRREEV", "down_seq": "ACATAVMSPEELLRAWIS", "snv": [ { "evidence": [ { "id": "Q6UXL0", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q6UXL0" } ], "glycoeffect": [], "subjects_tested": "92", "subjects_positive": "1", "frequency": "1.1", "sequence_org": "D", "sequence_mut": "A", "comment": "Somatic mutation passed 1 filters: patient freq. (1.1%).", "chr_id": "3", "chr_pos": "137010165", "ref_nt": "A", "alt_nt": "C", "minor_allelic_frequency": "", "site_lbl": "D293", "keywords": [ "biomuta", "somatic", "cancer" ] }, { "evidence": [ { "id": "Q6UXL0", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q6UXL0" } ], "glycoeffect": [], "subjects_tested": "92", "subjects_positive": "1", "frequency": "1.1", "sequence_org": "D", "sequence_mut": "Y", "comment": "Somatic mutation passed 1 filters: patient freq. (1.1%).", "chr_id": "3", "chr_pos": "137010164", "ref_nt": "G", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "D293", "keywords": [ "biomuta", "somatic", "cancer" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "134", "end_pos": "134" }, { "start_pos": "40", "end_pos": "40" } ] }, { "type": "snv", "site_list": [ { "start_pos": "112", "end_pos": "112" }, { "start_pos": "134", "end_pos": "134" }, { "start_pos": "136", "end_pos": "136" }, { "start_pos": "293", "end_pos": "293" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "40", "end_pos": "40" }, { "start_pos": "75", "end_pos": "75" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "upstream", "id": "Q6UXL0-1.297.297", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q6UXL0-1.297.297", "start_pos": 297, "end_pos": 297, "uniprot_canonical_ac": "Q6UXL0-1", "length": 311, "uniprot_id": "I20RB_HUMAN", "protein_name": "Interleukin-20 receptor subunit beta", "refseq_ac": "NP_653318", "refseq_name": "interleukin-20 receptor subunit beta precursor", "gene_name": "IL20RB", "gene_names_uniprotkb": "IL20RB; DIRS1; PRO1114", "gene_names_refseq": "DIRS1; FNDC6; IL-20R-beta; IL-20R2; IL-20RB; IL20RB", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q6UXL0", "url": "https://www.uniprot.org/uniprotkb/Q6UXL0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q6UXL0", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q6UXL0", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ITNSPQKLISCRREEVDACA", "down_seq": "AVMSPEELLRAWIS", "snv": [ { "evidence": [ { "id": "Q6UXL0", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q6UXL0" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "4177", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "T", "sequence_mut": "M", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "3", "chr_pos": "137010177", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "T297", "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "134", "end_pos": "134" }, { "start_pos": "40", "end_pos": "40" } ] }, { "type": "snv", "site_list": [ { "start_pos": "112", "end_pos": "112" }, { "start_pos": "134", "end_pos": "134" }, { "start_pos": "136", "end_pos": "136" }, { "start_pos": "293", "end_pos": "293" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "40", "end_pos": "40" }, { "start_pos": "75", "end_pos": "75" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "downstream", "id": "Q6UXL0-1.293.293", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q6UXL0-1.75.75", "start_pos": 75, "end_pos": 75, "uniprot_canonical_ac": "Q6UXL0-1", "length": 311, "uniprot_id": "I20RB_HUMAN", "protein_name": "Interleukin-20 receptor subunit beta", "refseq_ac": "NP_653318", "refseq_name": "interleukin-20 receptor subunit beta precursor", "gene_name": "IL20RB", "gene_names_uniprotkb": "IL20RB; DIRS1; PRO1114", "gene_names_refseq": "DIRS1; FNDC6; IL-20R-beta; IL-20R2; IL-20RB; IL20RB", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q6UXL0", "url": "https://www.uniprot.org/uniprotkb/Q6UXL0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q6UXL0", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q6UXL0", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "E", "start_aa": "E", "up_seq": "SPVIAPGETVYYSVEYQGEY", "down_seq": "SLYTSHIWIPSSWCSLTEGP", "snv": [ { "evidence": [ { "id": "Q6UXL0", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q6UXL0" } ], "glycoeffect": [], "subjects_tested": "92", "subjects_positive": "1", "frequency": "1.1", "sequence_org": "E", "sequence_mut": "K", "comment": "Somatic mutation passed 1 filters: patient freq. (1.1%).", "chr_id": "3", "chr_pos": "136982167", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "E75", "keywords": [ "biomuta", "somatic", "cancer" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "134", "end_pos": "134" }, { "start_pos": "40", "end_pos": "40" } ] }, { "type": "snv", "site_list": [ { "start_pos": "112", "end_pos": "112" }, { "start_pos": "134", "end_pos": "134" }, { "start_pos": "136", "end_pos": "136" }, { "start_pos": "293", "end_pos": "293" }, { "start_pos": "297", "end_pos": "297" }, { "start_pos": "40", "end_pos": "40" }, { "start_pos": "75", "end_pos": "75" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9NPG3-1.1002.1002", "start_pos": 1002, "end_pos": 1002, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "rs748952397", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs748952397", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs748952397", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs748952397", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs748952397", "url": "http://gnomad.broadinstitute.org/awesome?query=rs748952397", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QGVAKLLTSPSLKPSAVSSV", "down_seq": "SSTSLSKGASGTVLLAGSSL", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1002", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ] } ], "snv": [ { "evidence": [ { "id": "rs748952397", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs748952397" }, { "id": "rs748952397", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs748952397" }, { "id": "rs748952397", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs748952397" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (T->I).", "chr_id": "16", "chr_pos": "4875415", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T1002", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 13, "direction": "downstream", "id": "Q9NPG3-1.989.989", "categories": [ "glycosylation_flag" ] }, { "distance": 6, "direction": "downstream", "id": "Q9NPG3-1.996.996", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q9NPG3-1.999.999", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q9NPG3-1.1000.1000", "categories": [ "snv_flag" ] }, { "distance": 1, "direction": "upstream", "id": "Q9NPG3-1.1003.1003", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q9NPG3-1.1004.1004", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 21 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.1003.1003", "start_pos": 1003, "end_pos": 1003, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "Q9NPG3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs369575874", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs369575874", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs369575874", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs369575874", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs369575874", "url": "http://gnomad.broadinstitute.org/awesome?query=rs369575874", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "GVAKLLTSPSLKPSAVSSVT", "down_seq": "STSLSKGASGTVLLAGSSLM", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1003", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ] } ], "snv": [ { "evidence": [ { "id": "Q9NPG3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3" }, { "id": "rs369575874", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs369575874" }, { "id": "rs369575874", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs369575874" }, { "id": "rs369575874", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs369575874" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "2670", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "L", "comment": "Somatic mutation passed 1 filters: o-glyco-site-loss (S->L).", "chr_id": "16", "chr_pos": "4875418", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "S1003", "disease": [ { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ], "unlinked_id_list": [ "DOID:4203", "DOID:3541", "DOID:4706", "DOID:1659", "DOID:368" ], "evidence": [ { "id": "1319", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1319" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 14, "direction": "downstream", "id": "Q9NPG3-1.989.989", "categories": [ "glycosylation_flag" ] }, { "distance": 7, "direction": "downstream", "id": "Q9NPG3-1.996.996", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 4, "direction": "downstream", "id": "Q9NPG3-1.999.999", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q9NPG3-1.1000.1000", "categories": [ "snv_flag" ] }, { "distance": 1, "direction": "downstream", "id": "Q9NPG3-1.1002.1002", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 1, "direction": "upstream", "id": "Q9NPG3-1.1004.1004", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 21 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.1004.1004", "start_pos": 1004, "end_pos": 1004, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] }, { "title": "Methods for Enrichment and Assignment of N-Acetylglucosamine Modification Sites.", "journal": "Molecular & cellular proteomics : MCP", "date": "2021", "authors": "Maynard JC, Chalkley RJ", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32938750", "url": "https://glygen.org/publication/PubMed/32938750" } ] }, { "title": "Cell-type-specific labeling and profiling of glycans in living mice.", "journal": "Nature chemical biology", "date": "2022-06", "authors": "Fan Xinqi, Song Qitao, Sun De-En, Hao Yi, Wang Jingyang, Wang Chunting, Chen Xing", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35513511", "url": "https://glygen.org/publication/PubMed/35513511" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "32938750", "url": "https://glygen.org/publication/PubMed/32938750", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35513511", "url": "https://glygen.org/publication/PubMed/35513511", "database": "PubMed", "categories": [ "Other" ] }, { "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142", "database": "Data Submission", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "VAKLLTSPSLKPSAVSSVTS", "down_seq": "TSLSKGASGTVLLAGSSLMA", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1004", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "id": "32938750", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32938750" }, { "id": "35513511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35513511" } ] }, { "glytoucan_ac": "G70994MS", "type": "O-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1004", "evidence": [ { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "GLY_000142", "database": "Data Submission", "url": "http://data.glygen.org/GLY_000142" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 15, "direction": "downstream", "id": "Q9NPG3-1.989.989", "categories": [ "glycosylation_flag" ] }, { "distance": 8, "direction": "downstream", "id": "Q9NPG3-1.996.996", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 5, "direction": "downstream", "id": "Q9NPG3-1.999.999", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 4, "direction": "downstream", "id": "Q9NPG3-1.1000.1000", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q9NPG3-1.1002.1002", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 1, "direction": "downstream", "id": "Q9NPG3-1.1003.1003", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 2 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 2 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 23 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.611.611", "start_pos": 611, "end_pos": 611, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "VMAPSKIKVKESSTKPDKKV", "down_seq": "VPSGQIGGPIALPSDHQTGG", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser611", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" } ] } ], "snv": [ { "evidence": [ { "id": "Q9NPG3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "4484", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "Y", "comment": "Somatic mutation passed 1 filters: o-glyco-site-loss (S->Y).", "chr_id": "16", "chr_pos": "4874242", "ref_nt": "C", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "S611", "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 9, "direction": "downstream", "id": "Q9NPG3-1.602.602", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q9NPG3-1.609.609", "categories": [ "snv_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q9NPG3-1.614.614", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 16, "direction": "upstream", "id": "Q9NPG3-1.627.627", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 21 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.614.614", "start_pos": 614, "end_pos": 614, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "rs1370442829", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1370442829", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1370442829", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1370442829", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "PSKIKVKESSTKPDKKVSVP", "down_seq": "GQIGGPIALPSDHQTGGLSI", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser614", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" } ] } ], "snv": [ { "evidence": [ { "id": "rs1370442829", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1370442829" }, { "id": "rs1370442829", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1370442829" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "L", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (S->L).", "chr_id": "16", "chr_pos": "4874251", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S614", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 12, "direction": "downstream", "id": "Q9NPG3-1.602.602", "categories": [ "snv_flag" ] }, { "distance": 5, "direction": "downstream", "id": "Q9NPG3-1.609.609", "categories": [ "snv_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q9NPG3-1.611.611", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 13, "direction": "upstream", "id": "Q9NPG3-1.627.627", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 21 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.790.790", "start_pos": 790, "end_pos": 790, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] } ], "crossref": [ { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "rs1191185550", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1191185550", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1191185550", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1191185550#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "NKGLPEVHQSKAKHHSLPRT", "down_seq": "HGPQVAVPVPGPQVKVFHAG", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser790", "evidence": [ { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ] } ], "snv": [ { "evidence": [ { "id": "rs1191185550", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1191185550" }, { "id": "rs1191185550", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1191185550#frequency_tab" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "F", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (S->F).", "chr_id": "16", "chr_pos": "4874779", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S790", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 7, "direction": "downstream", "id": "Q9NPG3-1.783.783", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.857.857", "start_pos": 857, "end_pos": 857, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "rs1409952687", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1409952687", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1409952687", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1409952687", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "rs888351906", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs888351906", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs888351906", "url": "https://www.ensembl.org/id/rs888351906", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "CHRSLLQLVKTAAKGQGFHP", "down_seq": "APATSGGLSASSSSSHKTPA", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser857", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ] } ], "snv": [ { "evidence": [ { "id": "rs1409952687", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1409952687" }, { "id": "rs1409952687", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1409952687" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "P", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (S->P).", "chr_id": "16", "chr_pos": "4874979", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S857", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs888351906", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs888351906" }, { "id": "rs888351906", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs888351906" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "Y", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (S->Y).", "chr_id": "16", "chr_pos": "4874980", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S857", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "upstream", "id": "Q9NPG3-1.861.861", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 5, "direction": "upstream", "id": "Q9NPG3-1.862.862", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 9, "direction": "upstream", "id": "Q9NPG3-1.866.866", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 11, "direction": "upstream", "id": "Q9NPG3-1.868.868", "categories": [ "glycosylation_flag" ] }, { "distance": 12, "direction": "upstream", "id": "Q9NPG3-1.869.869", "categories": [ "glycosylation_flag" ] }, { "distance": 13, "direction": "upstream", "id": "Q9NPG3-1.870.870", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 15, "direction": "upstream", "id": "Q9NPG3-1.872.872", "categories": [ "glycosylation_flag" ] }, { "distance": 18, "direction": "upstream", "id": "Q9NPG3-1.875.875", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 21 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.861.861", "start_pos": 861, "end_pos": 861, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "rs762388807", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs762388807", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs762388807", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs762388807", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs762388807", "url": "http://gnomad.broadinstitute.org/awesome?query=rs762388807", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "rs757187213", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs757187213", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs757187213", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs757187213", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs757187213", "url": "https://www.ncbi.nlm.nih.gov/snp/rs757187213#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs757187213", "url": "http://gnomad.broadinstitute.org/awesome?query=rs757187213", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LLQLVKTAAKGQGFHPSAPA", "down_seq": "SGGLSASSSSSHKTPASSSS", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr861", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ] } ], "snv": [ { "evidence": [ { "id": "rs762388807", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs762388807" }, { "id": "rs762388807", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs762388807" }, { "id": "rs762388807", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs762388807" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (T->A).", "chr_id": "16", "chr_pos": "4874991", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T861", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs757187213", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs757187213" }, { "id": "rs757187213", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs757187213" }, { "id": "rs757187213", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs757187213#frequency_tab" }, { "id": "rs757187213", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs757187213" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (T->I).", "chr_id": "16", "chr_pos": "4874992", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T861", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "downstream", "id": "Q9NPG3-1.857.857", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 1, "direction": "upstream", "id": "Q9NPG3-1.862.862", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 5, "direction": "upstream", "id": "Q9NPG3-1.866.866", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 7, "direction": "upstream", "id": "Q9NPG3-1.868.868", "categories": [ "glycosylation_flag" ] }, { "distance": 8, "direction": "upstream", "id": "Q9NPG3-1.869.869", "categories": [ "glycosylation_flag" ] }, { "distance": 9, "direction": "upstream", "id": "Q9NPG3-1.870.870", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 11, "direction": "upstream", "id": "Q9NPG3-1.872.872", "categories": [ "glycosylation_flag" ] }, { "distance": 14, "direction": "upstream", "id": "Q9NPG3-1.875.875", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 17, "direction": "upstream", "id": "Q9NPG3-1.878.878", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 18, "direction": "upstream", "id": "Q9NPG3-1.879.879", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 19, "direction": "upstream", "id": "Q9NPG3-1.880.880", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 20, "direction": "upstream", "id": "Q9NPG3-1.881.881", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 21 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.862.862", "start_pos": 862, "end_pos": 862, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "rs528697141", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs528697141", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs528697141", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs528697141", "database": "1000Genomes", "categories": [ "Other" ] }, { "id": "rs528697141", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs528697141", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs528697141", "url": "http://gnomad.broadinstitute.org/awesome?query=rs528697141", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "LQLVKTAAKGQGFHPSAPAT", "down_seq": "GGLSASSSSSHKTPASSSSA", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser862", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ] } ], "snv": [ { "evidence": [ { "id": "rs528697141", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs528697141" }, { "id": "rs528697141", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs528697141" }, { "id": "rs528697141", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs528697141" }, { "id": "rs528697141", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs528697141" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "P", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (S->P).", "chr_id": "16", "chr_pos": "4874994", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "0.000196232", "site_lbl": "S862", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 5, "direction": "downstream", "id": "Q9NPG3-1.857.857", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 1, "direction": "downstream", "id": "Q9NPG3-1.861.861", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q9NPG3-1.866.866", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 6, "direction": "upstream", "id": "Q9NPG3-1.868.868", "categories": [ "glycosylation_flag" ] }, { "distance": 7, "direction": "upstream", "id": "Q9NPG3-1.869.869", "categories": [ "glycosylation_flag" ] }, { "distance": 8, "direction": "upstream", "id": "Q9NPG3-1.870.870", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 10, "direction": "upstream", "id": "Q9NPG3-1.872.872", "categories": [ "glycosylation_flag" ] }, { "distance": 13, "direction": "upstream", "id": "Q9NPG3-1.875.875", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 16, "direction": "upstream", "id": "Q9NPG3-1.878.878", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 17, "direction": "upstream", "id": "Q9NPG3-1.879.879", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 18, "direction": "upstream", "id": "Q9NPG3-1.880.880", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 19, "direction": "upstream", "id": "Q9NPG3-1.881.881", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 21 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.866.866", "start_pos": 866, "end_pos": 866, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "rs1285509422", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1285509422", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1285509422", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1285509422", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "KTAAKGQGFHPSAPATSGGL", "down_seq": "ASSSSSHKTPASSSSALSHP", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser866", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ] } ], "snv": [ { "evidence": [ { "id": "rs1285509422", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1285509422" }, { "id": "rs1285509422", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1285509422" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "L", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (S->L).", "chr_id": "16", "chr_pos": "4875007", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S866", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 9, "direction": "downstream", "id": "Q9NPG3-1.857.857", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 5, "direction": "downstream", "id": "Q9NPG3-1.861.861", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 4, "direction": "downstream", "id": "Q9NPG3-1.862.862", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q9NPG3-1.868.868", "categories": [ "glycosylation_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q9NPG3-1.869.869", "categories": [ "glycosylation_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q9NPG3-1.870.870", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 6, "direction": "upstream", "id": "Q9NPG3-1.872.872", "categories": [ "glycosylation_flag" ] }, { "distance": 9, "direction": "upstream", "id": "Q9NPG3-1.875.875", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 12, "direction": "upstream", "id": "Q9NPG3-1.878.878", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 13, "direction": "upstream", "id": "Q9NPG3-1.879.879", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 14, "direction": "upstream", "id": "Q9NPG3-1.880.880", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 15, "direction": "upstream", "id": "Q9NPG3-1.881.881", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 18, "direction": "upstream", "id": "Q9NPG3-1.884.884", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 21 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.868.868", "start_pos": 868, "end_pos": 868, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] } ], "crossref": [ { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "AAKGQGFHPSAPATSGGLSA", "down_seq": "SSSSHKTPASSSSALSHPAK", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser868", "evidence": [ { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 11, "direction": "downstream", "id": "Q9NPG3-1.857.857", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 7, "direction": "downstream", "id": "Q9NPG3-1.861.861", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 6, "direction": "downstream", "id": "Q9NPG3-1.862.862", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q9NPG3-1.866.866", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 1, "direction": "upstream", "id": "Q9NPG3-1.869.869", "categories": [ "glycosylation_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q9NPG3-1.870.870", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q9NPG3-1.872.872", "categories": [ "glycosylation_flag" ] }, { "distance": 7, "direction": "upstream", "id": "Q9NPG3-1.875.875", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 10, "direction": "upstream", "id": "Q9NPG3-1.878.878", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 11, "direction": "upstream", "id": "Q9NPG3-1.879.879", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 12, "direction": "upstream", "id": "Q9NPG3-1.880.880", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 13, "direction": "upstream", "id": "Q9NPG3-1.881.881", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 16, "direction": "upstream", "id": "Q9NPG3-1.884.884", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.869.869", "start_pos": 869, "end_pos": 869, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] } ], "crossref": [ { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "AKGQGFHPSAPATSGGLSAS", "down_seq": "SSSHKTPASSSSALSHPAKP", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser869", "evidence": [ { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 12, "direction": "downstream", "id": "Q9NPG3-1.857.857", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 8, "direction": "downstream", "id": "Q9NPG3-1.861.861", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 7, "direction": "downstream", "id": "Q9NPG3-1.862.862", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q9NPG3-1.866.866", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 1, "direction": "downstream", "id": "Q9NPG3-1.868.868", "categories": [ "glycosylation_flag" ] }, { "distance": 1, "direction": "upstream", "id": "Q9NPG3-1.870.870", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q9NPG3-1.872.872", "categories": [ "glycosylation_flag" ] }, { "distance": 6, "direction": "upstream", "id": "Q9NPG3-1.875.875", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 9, "direction": "upstream", "id": "Q9NPG3-1.878.878", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 10, "direction": "upstream", "id": "Q9NPG3-1.879.879", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 11, "direction": "upstream", "id": "Q9NPG3-1.880.880", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 12, "direction": "upstream", "id": "Q9NPG3-1.881.881", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 15, "direction": "upstream", "id": "Q9NPG3-1.884.884", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.870.870", "start_pos": 870, "end_pos": 870, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "rs757243889", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs757243889", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs757243889", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs757243889", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs757243889", "url": "http://gnomad.broadinstitute.org/awesome?query=rs757243889", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "KGQGFHPSAPATSGGLSASS", "down_seq": "SSHKTPASSSSALSHPAKPH", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser870", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ] } ], "snv": [ { "evidence": [ { "id": "rs757243889", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs757243889" }, { "id": "rs757243889", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs757243889" }, { "id": "rs757243889", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs757243889" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "G", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (S->G).", "chr_id": "16", "chr_pos": "4875018", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S870", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 13, "direction": "downstream", "id": "Q9NPG3-1.857.857", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 9, "direction": "downstream", "id": "Q9NPG3-1.861.861", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 8, "direction": "downstream", "id": "Q9NPG3-1.862.862", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 4, "direction": "downstream", "id": "Q9NPG3-1.866.866", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q9NPG3-1.868.868", "categories": [ "glycosylation_flag" ] }, { "distance": 1, "direction": "downstream", "id": "Q9NPG3-1.869.869", "categories": [ "glycosylation_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q9NPG3-1.872.872", "categories": [ "glycosylation_flag" ] }, { "distance": 5, "direction": "upstream", "id": "Q9NPG3-1.875.875", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 8, "direction": "upstream", "id": "Q9NPG3-1.878.878", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 9, "direction": "upstream", "id": "Q9NPG3-1.879.879", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 10, "direction": "upstream", "id": "Q9NPG3-1.880.880", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 11, "direction": "upstream", "id": "Q9NPG3-1.881.881", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 14, "direction": "upstream", "id": "Q9NPG3-1.884.884", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 21 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.872.872", "start_pos": 872, "end_pos": 872, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "QGFHPSAPATSGGLSASSSS", "down_seq": "HKTPASSSSALSHPAKPHSV", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser872", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 15, "direction": "downstream", "id": "Q9NPG3-1.857.857", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 11, "direction": "downstream", "id": "Q9NPG3-1.861.861", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 10, "direction": "downstream", "id": "Q9NPG3-1.862.862", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 6, "direction": "downstream", "id": "Q9NPG3-1.866.866", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 4, "direction": "downstream", "id": "Q9NPG3-1.868.868", "categories": [ "glycosylation_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q9NPG3-1.869.869", "categories": [ "glycosylation_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q9NPG3-1.870.870", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q9NPG3-1.875.875", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 6, "direction": "upstream", "id": "Q9NPG3-1.878.878", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 7, "direction": "upstream", "id": "Q9NPG3-1.879.879", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 8, "direction": "upstream", "id": "Q9NPG3-1.880.880", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 9, "direction": "upstream", "id": "Q9NPG3-1.881.881", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 12, "direction": "upstream", "id": "Q9NPG3-1.884.884", "categories": [ "glycosylation_flag" ] }, { "distance": 19, "direction": "upstream", "id": "Q9NPG3-1.891.891", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 21 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.875.875", "start_pos": 875, "end_pos": 875, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] }, { "title": "Cell-type-specific labeling and profiling of glycans in living mice.", "journal": "Nature chemical biology", "date": "2022-06", "authors": "Fan Xinqi, Song Qitao, Sun De-En, Hao Yi, Wang Jingyang, Wang Chunting, Chen Xing", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35513511", "url": "https://glygen.org/publication/PubMed/35513511" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "35513511", "url": "https://glygen.org/publication/PubMed/35513511", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs1596525864", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1596525864", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1596525864", "url": "https://www.ensembl.org/id/rs1596525864", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "HPSAPATSGGLSASSSSSHK", "down_seq": "PASSSSALSHPAKPHSVSSA", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr875", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "id": "35513511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35513511" } ] } ], "snv": [ { "evidence": [ { "id": "Q9NPG3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "1557", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "T", "sequence_mut": "A", "comment": "Somatic mutation passed 1 filters: o-glyco-site-loss (T->A).", "chr_id": "16", "chr_pos": "4875033", "ref_nt": "A", "alt_nt": "G", "minor_allelic_frequency": "", "site_lbl": "T875", "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3675", "DOID:4455" ], "evidence": [ { "id": "263", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:263" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs1596525864", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1596525864" }, { "id": "rs1596525864", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1596525864" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "T", "sequence_mut": "P", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (T->P).", "chr_id": "16", "chr_pos": "4875033", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T875", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 18, "direction": "downstream", "id": "Q9NPG3-1.857.857", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 14, "direction": "downstream", "id": "Q9NPG3-1.861.861", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 13, "direction": "downstream", "id": "Q9NPG3-1.862.862", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 9, "direction": "downstream", "id": "Q9NPG3-1.866.866", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 7, "direction": "downstream", "id": "Q9NPG3-1.868.868", "categories": [ "glycosylation_flag" ] }, { "distance": 6, "direction": "downstream", "id": "Q9NPG3-1.869.869", "categories": [ "glycosylation_flag" ] }, { "distance": 5, "direction": "downstream", "id": "Q9NPG3-1.870.870", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q9NPG3-1.872.872", "categories": [ "glycosylation_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q9NPG3-1.878.878", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q9NPG3-1.879.879", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 5, "direction": "upstream", "id": "Q9NPG3-1.880.880", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 6, "direction": "upstream", "id": "Q9NPG3-1.881.881", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 9, "direction": "upstream", "id": "Q9NPG3-1.884.884", "categories": [ "glycosylation_flag" ] }, { "distance": 16, "direction": "upstream", "id": "Q9NPG3-1.891.891", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 19, "direction": "upstream", "id": "Q9NPG3-1.894.894", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 22 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.878.878", "start_pos": 878, "end_pos": 878, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] }, { "title": "O-GlcNAcylation of Raptor transduces glucose signals to mTORC1.", "journal": "Molecular cell", "date": "2023-08-17", "authors": "Xu Chenchen, Pan Xiaoqing, Wang Dong, Guan Yuanyuan, Yang Wenyu, Chen Xing, Liu Ying", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "37541260", "url": "https://glygen.org/publication/PubMed/37541260" } ] }, { "title": "Cell-type-specific labeling and profiling of glycans in living mice.", "journal": "Nature chemical biology", "date": "2022-06", "authors": "Fan Xinqi, Song Qitao, Sun De-En, Hao Yi, Wang Jingyang, Wang Chunting, Chen Xing", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35513511", "url": "https://glygen.org/publication/PubMed/35513511" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "37541260", "url": "https://glygen.org/publication/PubMed/37541260", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35513511", "url": "https://glygen.org/publication/PubMed/35513511", "database": "PubMed", "categories": [ "Other" ] }, { "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142", "database": "Data Submission", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs113062408", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs113062408", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs113062408", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs113062408", "database": "1000Genomes", "categories": [ "Other" ] }, { "id": "rs113062408", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs113062408", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs113062408", "url": "https://www.ncbi.nlm.nih.gov/snp/rs113062408#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs113062408", "url": "http://gnomad.broadinstitute.org/awesome?query=rs113062408", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "APATSGGLSASSSSSHKTPA", "down_seq": "SSSALSHPAKPHSVSSAGSS", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser878", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "id": "37541260", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37541260" }, { "id": "35513511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35513511" } ] }, { "glytoucan_ac": "G70994MS", "type": "O-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser878", "evidence": [ { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "GLY_000142", "database": "Data Submission", "url": "http://data.glygen.org/GLY_000142" } ] } ], "snv": [ { "evidence": [ { "id": "Q9NPG3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3" }, { "id": "rs113062408", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs113062408" }, { "id": "rs113062408", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs113062408" }, { "id": "rs113062408", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs113062408" }, { "id": "rs113062408", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs113062408#frequency_tab" }, { "id": "rs113062408", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs113062408" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "1704", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "S", "sequence_mut": "L", "comment": "Somatic mutation passed 1 filters: o-glyco-site-loss (S->L).", "chr_id": "16", "chr_pos": "4875043", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "S878", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 17, "direction": "downstream", "id": "Q9NPG3-1.861.861", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 16, "direction": "downstream", "id": "Q9NPG3-1.862.862", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 12, "direction": "downstream", "id": "Q9NPG3-1.866.866", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 10, "direction": "downstream", "id": "Q9NPG3-1.868.868", "categories": [ "glycosylation_flag" ] }, { "distance": 9, "direction": "downstream", "id": "Q9NPG3-1.869.869", "categories": [ "glycosylation_flag" ] }, { "distance": 8, "direction": "downstream", "id": "Q9NPG3-1.870.870", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 6, "direction": "downstream", "id": "Q9NPG3-1.872.872", "categories": [ "glycosylation_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q9NPG3-1.875.875", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 1, "direction": "upstream", "id": "Q9NPG3-1.879.879", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q9NPG3-1.880.880", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q9NPG3-1.881.881", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 6, "direction": "upstream", "id": "Q9NPG3-1.884.884", "categories": [ "glycosylation_flag" ] }, { "distance": 13, "direction": "upstream", "id": "Q9NPG3-1.891.891", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 16, "direction": "upstream", "id": "Q9NPG3-1.894.894", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 19, "direction": "upstream", "id": "Q9NPG3-1.897.897", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 20, "direction": "upstream", "id": "Q9NPG3-1.898.898", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 2 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 2 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 23 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.879.879", "start_pos": 879, "end_pos": 879, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142", "database": "Data Submission", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs1173461612", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1173461612", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1173461612", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1173461612", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "rs1173461612", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs1173461612", "database": "COSMIC", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "PATSGGLSASSSSSHKTPAS", "down_seq": "SSALSHPAKPHSVSSAGSSY", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser879", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ] }, { "glytoucan_ac": "G70994MS", "type": "O-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser879", "evidence": [ { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "GLY_000142", "database": "Data Submission", "url": "http://data.glygen.org/GLY_000142" } ] } ], "snv": [ { "evidence": [ { "id": "Q9NPG3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3" }, { "id": "rs1173461612", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1173461612" }, { "id": "rs1173461612", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1173461612" }, { "id": "rs1173461612", "database": "COSMIC", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs1173461612" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "2053", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "F", "comment": "Somatic mutation passed 1 filters: o-glyco-site-loss (S->F).", "chr_id": "16", "chr_pos": "4875046", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "S879", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 18, "direction": "downstream", "id": "Q9NPG3-1.861.861", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 17, "direction": "downstream", "id": "Q9NPG3-1.862.862", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 13, "direction": "downstream", "id": "Q9NPG3-1.866.866", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 11, "direction": "downstream", "id": "Q9NPG3-1.868.868", "categories": [ "glycosylation_flag" ] }, { "distance": 10, "direction": "downstream", "id": "Q9NPG3-1.869.869", "categories": [ "glycosylation_flag" ] }, { "distance": 9, "direction": "downstream", "id": "Q9NPG3-1.870.870", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 7, "direction": "downstream", "id": "Q9NPG3-1.872.872", "categories": [ "glycosylation_flag" ] }, { "distance": 4, "direction": "downstream", "id": "Q9NPG3-1.875.875", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 1, "direction": "downstream", "id": "Q9NPG3-1.878.878", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 1, "direction": "upstream", "id": "Q9NPG3-1.880.880", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q9NPG3-1.881.881", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 5, "direction": "upstream", "id": "Q9NPG3-1.884.884", "categories": [ "glycosylation_flag" ] }, { "distance": 12, "direction": "upstream", "id": "Q9NPG3-1.891.891", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 15, "direction": "upstream", "id": "Q9NPG3-1.894.894", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 18, "direction": "upstream", "id": "Q9NPG3-1.897.897", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 19, "direction": "upstream", "id": "Q9NPG3-1.898.898", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 2 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 2 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 21 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.880.880", "start_pos": 880, "end_pos": 880, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "Q9NPG3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs1403345413", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1403345413", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1403345413", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1403345413", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "rs2142277571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2142277571", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs2142277571", "url": "https://www.ensembl.org/id/rs2142277571", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "ATSGGLSASSSSSHKTPASS", "down_seq": "SALSHPAKPHSVSSAGSSYK", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser880", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ] } ], "snv": [ { "evidence": [ { "id": "Q9NPG3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "2053", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "C", "comment": "Somatic mutation passed 1 filters: o-glyco-site-loss (S->C).", "chr_id": "16", "chr_pos": "4875049", "ref_nt": "C", "alt_nt": "G", "minor_allelic_frequency": "", "site_lbl": "S880", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "Q9NPG3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3" }, { "id": "rs1403345413", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1403345413" }, { "id": "rs1403345413", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1403345413" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "4484", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "F", "comment": "Somatic mutation passed 1 filters: o-glyco-site-loss (S->F).", "chr_id": "16", "chr_pos": "4875049", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "S880", "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] }, { "evidence": [ { "id": "rs2142277571", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2142277571" }, { "id": "rs2142277571", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs2142277571" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "P", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (S->P).", "chr_id": "16", "chr_pos": "4875048", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S880", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "Q9NPG3-1.861.861", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 18, "direction": "downstream", "id": "Q9NPG3-1.862.862", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 14, "direction": "downstream", "id": "Q9NPG3-1.866.866", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 12, "direction": "downstream", "id": "Q9NPG3-1.868.868", "categories": [ "glycosylation_flag" ] }, { "distance": 11, "direction": "downstream", "id": "Q9NPG3-1.869.869", "categories": [ "glycosylation_flag" ] }, { "distance": 10, "direction": "downstream", "id": "Q9NPG3-1.870.870", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 8, "direction": "downstream", "id": "Q9NPG3-1.872.872", "categories": [ "glycosylation_flag" ] }, { "distance": 5, "direction": "downstream", "id": "Q9NPG3-1.875.875", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q9NPG3-1.878.878", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 1, "direction": "downstream", "id": "Q9NPG3-1.879.879", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 1, "direction": "upstream", "id": "Q9NPG3-1.881.881", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q9NPG3-1.884.884", "categories": [ "glycosylation_flag" ] }, { "distance": 11, "direction": "upstream", "id": "Q9NPG3-1.891.891", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 14, "direction": "upstream", "id": "Q9NPG3-1.894.894", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 17, "direction": "upstream", "id": "Q9NPG3-1.897.897", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 18, "direction": "upstream", "id": "Q9NPG3-1.898.898", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 21 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.881.881", "start_pos": 881, "end_pos": 881, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "Q9NPG3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "TSGGLSASSSSSHKTPASSS", "down_seq": "ALSHPAKPHSVSSAGSSYKN", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser881", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ] } ], "snv": [ { "evidence": [ { "id": "Q9NPG3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "320", "subjects_positive": "1", "frequency": "0.3", "sequence_org": "S", "sequence_mut": "F", "comment": "Somatic mutation passed 1 filters: o-glyco-site-loss (S->F).", "chr_id": "16", "chr_pos": "4875052", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "S881", "disease": [ { "disease_id": "DOID:4362", "recommended_name": { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervical cancer", "description": "A female reproductive organ cancer that is located_in the cervix." }, "synonyms": [ { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervical neoplasm", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervix cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervix uteri cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "neoplasm of uterine cervix", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "tumor of the Cervix Uteri", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer", "description": "A primary or metastatic malignant neoplasm involving the cervix." }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cancer of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer, somatic", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervix cancer", "description": "" }, { "id": "MIM:603956", "resource": "MIM", "url": "https://www.omim.org/entry/603956", "name": "Cervical cancer", "description": "Cervical cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "4362", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4362" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 20, "direction": "downstream", "id": "Q9NPG3-1.861.861", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 19, "direction": "downstream", "id": "Q9NPG3-1.862.862", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 15, "direction": "downstream", "id": "Q9NPG3-1.866.866", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 13, "direction": "downstream", "id": "Q9NPG3-1.868.868", "categories": [ "glycosylation_flag" ] }, { "distance": 12, "direction": "downstream", "id": "Q9NPG3-1.869.869", "categories": [ "glycosylation_flag" ] }, { "distance": 11, "direction": "downstream", "id": "Q9NPG3-1.870.870", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 9, "direction": "downstream", "id": "Q9NPG3-1.872.872", "categories": [ "glycosylation_flag" ] }, { "distance": 6, "direction": "downstream", "id": "Q9NPG3-1.875.875", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q9NPG3-1.878.878", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q9NPG3-1.879.879", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 1, "direction": "downstream", "id": "Q9NPG3-1.880.880", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q9NPG3-1.884.884", "categories": [ "glycosylation_flag" ] }, { "distance": 10, "direction": "upstream", "id": "Q9NPG3-1.891.891", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 13, "direction": "upstream", "id": "Q9NPG3-1.894.894", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 16, "direction": "upstream", "id": "Q9NPG3-1.897.897", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 17, "direction": "upstream", "id": "Q9NPG3-1.898.898", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 21 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.884.884", "start_pos": 884, "end_pos": 884, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "GLSASSSSSHKTPASSSSAL", "down_seq": "HPAKPHSVSSAGSSYKNNPF", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser884", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 18, "direction": "downstream", "id": "Q9NPG3-1.866.866", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 16, "direction": "downstream", "id": "Q9NPG3-1.868.868", "categories": [ "glycosylation_flag" ] }, { "distance": 15, "direction": "downstream", "id": "Q9NPG3-1.869.869", "categories": [ "glycosylation_flag" ] }, { "distance": 14, "direction": "downstream", "id": "Q9NPG3-1.870.870", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 12, "direction": "downstream", "id": "Q9NPG3-1.872.872", "categories": [ "glycosylation_flag" ] }, { "distance": 9, "direction": "downstream", "id": "Q9NPG3-1.875.875", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 6, "direction": "downstream", "id": "Q9NPG3-1.878.878", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 5, "direction": "downstream", "id": "Q9NPG3-1.879.879", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 4, "direction": "downstream", "id": "Q9NPG3-1.880.880", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q9NPG3-1.881.881", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 7, "direction": "upstream", "id": "Q9NPG3-1.891.891", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 10, "direction": "upstream", "id": "Q9NPG3-1.894.894", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 13, "direction": "upstream", "id": "Q9NPG3-1.897.897", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 14, "direction": "upstream", "id": "Q9NPG3-1.898.898", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 19, "direction": "upstream", "id": "Q9NPG3-1.903.903", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 21 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.891.891", "start_pos": 891, "end_pos": 891, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "rs766740021", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs766740021", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs766740021", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs766740021", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs766740021", "url": "https://www.ncbi.nlm.nih.gov/snp/rs766740021#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs766740021", "url": "http://gnomad.broadinstitute.org/awesome?query=rs766740021", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "SSHKTPASSSSALSHPAKPH", "down_seq": "VSSAGSSYKNNPFASSISKH", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser891", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ] } ], "snv": [ { "evidence": [ { "id": "rs766740021", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs766740021" }, { "id": "rs766740021", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs766740021" }, { "id": "rs766740021", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs766740021#frequency_tab" }, { "id": "rs766740021", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs766740021" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "A", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (S->A).", "chr_id": "16", "chr_pos": "4875081", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S891", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "Q9NPG3-1.872.872", "categories": [ "glycosylation_flag" ] }, { "distance": 16, "direction": "downstream", "id": "Q9NPG3-1.875.875", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 13, "direction": "downstream", "id": "Q9NPG3-1.878.878", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 12, "direction": "downstream", "id": "Q9NPG3-1.879.879", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 11, "direction": "downstream", "id": "Q9NPG3-1.880.880", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 10, "direction": "downstream", "id": "Q9NPG3-1.881.881", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 7, "direction": "downstream", "id": "Q9NPG3-1.884.884", "categories": [ "glycosylation_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q9NPG3-1.894.894", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 6, "direction": "upstream", "id": "Q9NPG3-1.897.897", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 7, "direction": "upstream", "id": "Q9NPG3-1.898.898", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 12, "direction": "upstream", "id": "Q9NPG3-1.903.903", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 21 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.894.894", "start_pos": 894, "end_pos": 894, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "rs1201897988", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1201897988", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1201897988", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1201897988", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "KTPASSSSALSHPAKPHSVS", "down_seq": "AGSSYKNNPFASSISKHGVS", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser894", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ] } ], "snv": [ { "evidence": [ { "id": "rs1201897988", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1201897988" }, { "id": "rs1201897988", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1201897988" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "F", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (S->F).", "chr_id": "16", "chr_pos": "4875091", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S894", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "Q9NPG3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "1704", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "S", "sequence_mut": "Y", "comment": "Somatic mutation passed 1 filters: o-glyco-site-loss (S->Y).", "chr_id": "16", "chr_pos": "4875091", "ref_nt": "C", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "S894", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "Q9NPG3-1.875.875", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 16, "direction": "downstream", "id": "Q9NPG3-1.878.878", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 15, "direction": "downstream", "id": "Q9NPG3-1.879.879", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 14, "direction": "downstream", "id": "Q9NPG3-1.880.880", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 13, "direction": "downstream", "id": "Q9NPG3-1.881.881", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 10, "direction": "downstream", "id": "Q9NPG3-1.884.884", "categories": [ "glycosylation_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q9NPG3-1.891.891", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q9NPG3-1.897.897", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q9NPG3-1.898.898", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 9, "direction": "upstream", "id": "Q9NPG3-1.903.903", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 21 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.897.897", "start_pos": 897, "end_pos": 897, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "rs1031985543", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1031985543", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1031985543", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1031985543#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs1031985543", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1031985543", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "rs2087816929", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2087816929", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs2087816929", "url": "https://www.ncbi.nlm.nih.gov/snp/rs2087816929#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "ASSSSALSHPAKPHSVSSAG", "down_seq": "SYKNNPFASSISKHGVSSGS", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser897", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ] } ], "snv": [ { "evidence": [ { "id": "rs1031985543", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1031985543" }, { "id": "rs1031985543", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1031985543#frequency_tab" }, { "id": "rs1031985543", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1031985543" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "L", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (S->L).", "chr_id": "16", "chr_pos": "4875100", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S897", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs2087816929", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2087816929" }, { "id": "rs2087816929", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs2087816929#frequency_tab" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "P", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (S->P).", "chr_id": "16", "chr_pos": "4875099", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S897", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "Q9NPG3-1.878.878", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 18, "direction": "downstream", "id": "Q9NPG3-1.879.879", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 17, "direction": "downstream", "id": "Q9NPG3-1.880.880", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 16, "direction": "downstream", "id": "Q9NPG3-1.881.881", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 13, "direction": "downstream", "id": "Q9NPG3-1.884.884", "categories": [ "glycosylation_flag" ] }, { "distance": 6, "direction": "downstream", "id": "Q9NPG3-1.891.891", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q9NPG3-1.894.894", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 1, "direction": "upstream", "id": "Q9NPG3-1.898.898", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 6, "direction": "upstream", "id": "Q9NPG3-1.903.903", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 21 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.898.898", "start_pos": 898, "end_pos": 898, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "rs151331085", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs151331085", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs151331085", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs151331085", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs151331085", "url": "https://www.ncbi.nlm.nih.gov/snp/rs151331085#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs151331085", "url": "http://gnomad.broadinstitute.org/awesome?query=rs151331085", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "SSSSALSHPAKPHSVSSAGS", "down_seq": "YKNNPFASSISKHGVSSGSS", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser898", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ] } ], "snv": [ { "evidence": [ { "id": "rs151331085", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs151331085" }, { "id": "rs151331085", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs151331085" }, { "id": "rs151331085", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs151331085#frequency_tab" }, { "id": "rs151331085", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs151331085" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "F", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (S->F).", "chr_id": "16", "chr_pos": "4875103", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S898", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 20, "direction": "downstream", "id": "Q9NPG3-1.878.878", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 19, "direction": "downstream", "id": "Q9NPG3-1.879.879", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 18, "direction": "downstream", "id": "Q9NPG3-1.880.880", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 17, "direction": "downstream", "id": "Q9NPG3-1.881.881", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 14, "direction": "downstream", "id": "Q9NPG3-1.884.884", "categories": [ "glycosylation_flag" ] }, { "distance": 7, "direction": "downstream", "id": "Q9NPG3-1.891.891", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 4, "direction": "downstream", "id": "Q9NPG3-1.894.894", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 1, "direction": "downstream", "id": "Q9NPG3-1.897.897", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 5, "direction": "upstream", "id": "Q9NPG3-1.903.903", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 21 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.989.989", "start_pos": 989, "end_pos": 989, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PPGGPNGDSSGGTQGVAKLL", "down_seq": "SPSLKPSAVSSVTSSTSLSK", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr989", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 11, "direction": "downstream", "id": "Q9NPG3-1.978.978", "categories": [ "phosphorylation_flag" ] }, { "distance": 8, "direction": "downstream", "id": "Q9NPG3-1.981.981", "categories": [ "phosphorylation_flag" ] }, { "distance": 7, "direction": "upstream", "id": "Q9NPG3-1.996.996", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 10, "direction": "upstream", "id": "Q9NPG3-1.999.999", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 11, "direction": "upstream", "id": "Q9NPG3-1.1000.1000", "categories": [ "snv_flag" ] }, { "distance": 13, "direction": "upstream", "id": "Q9NPG3-1.1002.1002", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 14, "direction": "upstream", "id": "Q9NPG3-1.1003.1003", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 15, "direction": "upstream", "id": "Q9NPG3-1.1004.1004", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 21 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.996.996", "start_pos": 996, "end_pos": 996, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "rs778969367", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778969367", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs778969367", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778969367", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs778969367", "url": "https://www.ncbi.nlm.nih.gov/snp/rs778969367#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs778969367", "url": "http://gnomad.broadinstitute.org/awesome?query=rs778969367", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "rs2087830537", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2087830537", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs2087830537", "url": "https://www.ensembl.org/id/rs2087830537", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "DSSGGTQGVAKLLTSPSLKP", "down_seq": "AVSSVTSSTSLSKGASGTVL", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser996", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ] } ], "snv": [ { "evidence": [ { "id": "rs778969367", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778969367" }, { "id": "rs778969367", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778969367" }, { "id": "rs778969367", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs778969367#frequency_tab" }, { "id": "rs778969367", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs778969367" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "C", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (S->C).", "chr_id": "16", "chr_pos": "4875397", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S996", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs778969367", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778969367" }, { "id": "rs778969367", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778969367" }, { "id": "rs778969367", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs778969367#frequency_tab" }, { "id": "rs778969367", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs778969367" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "F", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (S->F).", "chr_id": "16", "chr_pos": "4875397", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S996", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs2087830537", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2087830537" }, { "id": "rs2087830537", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs2087830537" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "P", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (S->P).", "chr_id": "16", "chr_pos": "4875396", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S996", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 18, "direction": "downstream", "id": "Q9NPG3-1.978.978", "categories": [ "phosphorylation_flag" ] }, { "distance": 15, "direction": "downstream", "id": "Q9NPG3-1.981.981", "categories": [ "phosphorylation_flag" ] }, { "distance": 7, "direction": "downstream", "id": "Q9NPG3-1.989.989", "categories": [ "glycosylation_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q9NPG3-1.999.999", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q9NPG3-1.1000.1000", "categories": [ "snv_flag" ] }, { "distance": 6, "direction": "upstream", "id": "Q9NPG3-1.1002.1002", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 7, "direction": "upstream", "id": "Q9NPG3-1.1003.1003", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 8, "direction": "upstream", "id": "Q9NPG3-1.1004.1004", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 21 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.999.999", "start_pos": 999, "end_pos": 999, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.", "journal": "Cancer immunology research", "date": "2017", "authors": "Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2016", "authors": "Lee JS, Zhang Z", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568" } ] }, { "title": "Methods for Enrichment and Assignment of N-Acetylglucosamine Modification Sites.", "journal": "Molecular & cellular proteomics : MCP", "date": "2021", "authors": "Maynard JC, Chalkley RJ", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "32938750", "url": "https://glygen.org/publication/PubMed/32938750" } ] } ], "crossref": [ { "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244", "database": "PubMed", "categories": [ "Other" ] }, { "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247", "database": "PubMed", "categories": [ "Other" ] }, { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842", "database": "PubMed", "categories": [ "Other" ] }, { "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551", "database": "PubMed", "categories": [ "Other" ] }, { "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948", "database": "PubMed", "categories": [ "Other" ] }, { "id": "28314751", "url": "https://glygen.org/publication/PubMed/28314751", "database": "PubMed", "categories": [ "Other" ] }, { "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497", "database": "PubMed", "categories": [ "Other" ] }, { "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053", "database": "PubMed", "categories": [ "Other" ] }, { "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916", "database": "PubMed", "categories": [ "Other" ] }, { "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862", "database": "PubMed", "categories": [ "Other" ] }, { "id": "27217568", "url": "https://glygen.org/publication/PubMed/27217568", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://oglcnac.org/atlas/detail/Q9NPG3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "32938750", "url": "https://glygen.org/publication/PubMed/32938750", "database": "PubMed", "categories": [ "Other" ] }, { "id": "rs2087831293", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2087831293", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs2087831293", "url": "https://www.ncbi.nlm.nih.gov/snp/rs2087831293#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs747396567", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs747396567", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs747396567", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs747396567", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs747396567", "url": "http://gnomad.broadinstitute.org/awesome?query=rs747396567", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "GGTQGVAKLLTSPSLKPSAV", "down_seq": "SVTSSTSLSKGASGTVLLAG", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser999", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NPG3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NPG3" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "40596516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40596516" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34846842", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34846842" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28314751", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28314751" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "27217568", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27217568" }, { "id": "Q9NPG3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9NPG3" }, { "id": "32938750", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32938750" } ] } ], "snv": [ { "evidence": [ { "id": "rs2087831293", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2087831293" }, { "id": "rs2087831293", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs2087831293#frequency_tab" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "C", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (S->C).", "chr_id": "16", "chr_pos": "4875405", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S999", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs747396567", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs747396567" }, { "id": "rs747396567", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs747396567" }, { "id": "rs747396567", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs747396567" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (S->N).", "chr_id": "16", "chr_pos": "4875406", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S999", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 18, "direction": "downstream", "id": "Q9NPG3-1.981.981", "categories": [ "phosphorylation_flag" ] }, { "distance": 10, "direction": "downstream", "id": "Q9NPG3-1.989.989", "categories": [ "glycosylation_flag" ] }, { "distance": 3, "direction": "downstream", "id": "Q9NPG3-1.996.996", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 1, "direction": "upstream", "id": "Q9NPG3-1.1000.1000", "categories": [ "snv_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q9NPG3-1.1002.1002", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q9NPG3-1.1003.1003", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 5, "direction": "upstream", "id": "Q9NPG3-1.1004.1004", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 22 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.138.138", "start_pos": 138, "end_pos": 138, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "site_seq": "F", "start_aa": "F", "up_seq": "RKDRIQDLIDMGYGYDESDS", "down_seq": "IDNSEAYDELVPASLTTKYG", "mutagenesis": [ { "sequence_org": "F", "sequence_mut": "E", "comment": "Strongly diminishes interaction with HIRA; when associated with E-139 and L-140.", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 1, "direction": "upstream", "id": "Q9NPG3-1.139.139", "categories": [ "mutagenesis_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q9NPG3-1.140.140", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9NPG3-1.139.139", "start_pos": 139, "end_pos": 139, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "site_seq": "I", "start_aa": "I", "up_seq": "KDRIQDLIDMGYGYDESDSF", "down_seq": "DNSEAYDELVPASLTTKYGG", "mutagenesis": [ { "sequence_org": "I", "sequence_mut": "E", "comment": "Strongly diminishes interaction with HIRA; when associated with E-138 and L-140.", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 1, "direction": "downstream", "id": "Q9NPG3-1.138.138", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "upstream", "id": "Q9NPG3-1.140.140", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9NPG3-1.140.140", "start_pos": 140, "end_pos": 140, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "DRIQDLIDMGYGYDESDSFI", "down_seq": "NSEAYDELVPASLTTKYGGF", "mutagenesis": [ { "sequence_org": "D", "sequence_mut": "L", "comment": "Strongly diminishes interaction with HIRA; when associated with E-138 and L-139.", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "downstream", "id": "Q9NPG3-1.138.138", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "downstream", "id": "Q9NPG3-1.139.139", "categories": [ "mutagenesis_flag" ] }, { "distance": 20, "direction": "upstream", "id": "Q9NPG3-1.160.160", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9NPG3-1.160.160", "start_pos": 160, "end_pos": 160, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells.", "journal": "Molecular and cellular biology", "date": "2009", "authors": "Banumathy G, Somaiah N, Zhang R, Tang Y, Hoffmann J, Andrake M, Ceulemans H, Schultz D, Marmorstein R, Adams PD", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "Reactome", "id": "R-HSA-2559584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559584" }, { "database": "RefSeq", "id": "NP_001072982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001072982" } ], "reference": [ { "type": "PubMed", "id": "19029251", "url": "https://glygen.org/publication/PubMed/19029251" } ] } ], "crossref": [ { "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "19029251", "url": "https://glygen.org/publication/PubMed/19029251", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "F", "start_aa": "F", "up_seq": "DNSEAYDELVPASLTTKYGG", "down_seq": "YINSGTLQFRQASESEDDFI", "mutagenesis": [ { "sequence_org": "F", "sequence_mut": "E", "comment": "Strongly diminishes interaction with HIRA.", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "PubMed", "id": "19029251", "url": "https://glygen.org/publication/PubMed/19029251" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 20, "direction": "downstream", "id": "Q9NPG3-1.140.140", "categories": [ "mutagenesis_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q9NPG3-1.162.162", "categories": [ "mutagenesis_flag" ] }, { "distance": 6, "direction": "upstream", "id": "Q9NPG3-1.166.166", "categories": [ "phosphorylation_flag" ] }, { "distance": 13, "direction": "upstream", "id": "Q9NPG3-1.173.173", "categories": [ "phosphorylation_flag" ] }, { "distance": 15, "direction": "upstream", "id": "Q9NPG3-1.175.175", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.162.162", "start_pos": 162, "end_pos": 162, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells.", "journal": "Molecular and cellular biology", "date": "2009", "authors": "Banumathy G, Somaiah N, Zhang R, Tang Y, Hoffmann J, Andrake M, Ceulemans H, Schultz D, Marmorstein R, Adams PD", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "Reactome", "id": "R-HSA-2559584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559584" }, { "database": "RefSeq", "id": "NP_001072982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001072982" } ], "reference": [ { "type": "PubMed", "id": "19029251", "url": "https://glygen.org/publication/PubMed/19029251" } ] } ], "crossref": [ { "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "19029251", "url": "https://glygen.org/publication/PubMed/19029251", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "I", "start_aa": "I", "up_seq": "SEAYDELVPASLTTKYGGFY", "down_seq": "NSGTLQFRQASESEDDFIKE", "mutagenesis": [ { "sequence_org": "I", "sequence_mut": "E", "comment": "Strongly diminishes interaction with HIRA.", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "PubMed", "id": "19029251", "url": "https://glygen.org/publication/PubMed/19029251" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "downstream", "id": "Q9NPG3-1.160.160", "categories": [ "mutagenesis_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q9NPG3-1.166.166", "categories": [ "phosphorylation_flag" ] }, { "distance": 11, "direction": "upstream", "id": "Q9NPG3-1.173.173", "categories": [ "phosphorylation_flag" ] }, { "distance": 13, "direction": "upstream", "id": "Q9NPG3-1.175.175", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.1000.1000", "start_pos": 1000, "end_pos": 1000, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs531063324", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs531063324", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs531063324", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs531063324", "database": "1000Genomes", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "GTQGVAKLLTSPSLKPSAVS", "down_seq": "VTSSTSLSKGASGTVLLAGS", "snv": [ { "evidence": [ { "id": "rs531063324", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs531063324" }, { "id": "rs531063324", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs531063324" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (SVT->NVT).", "chr_id": "16", "chr_pos": "4875409", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "0.000196232", "site_lbl": "S1000", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "Q9NPG3-1.981.981", "categories": [ "phosphorylation_flag" ] }, { "distance": 11, "direction": "downstream", "id": "Q9NPG3-1.989.989", "categories": [ "glycosylation_flag" ] }, { "distance": 4, "direction": "downstream", "id": "Q9NPG3-1.996.996", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 1, "direction": "downstream", "id": "Q9NPG3-1.999.999", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q9NPG3-1.1002.1002", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 3, "direction": "upstream", "id": "Q9NPG3-1.1003.1003", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q9NPG3-1.1004.1004", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9NPG3-1.206.206", "start_pos": 206, "end_pos": 206, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q9NPG3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "KSPKKRKLKEGGEKIKKKKK", "down_seq": "DTYDKEKKSKKSKFSKAGFT", "snv": [ { "evidence": [ { "id": "Q9NPG3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "subjects_tested": "1704", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (DDT->NDT).", "chr_id": "16", "chr_pos": "4859913", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "D206", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 13, "direction": "upstream", "id": "Q9NPG3-1.219.219", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9NPG3-1.219.219", "start_pos": 219, "end_pos": 219, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs2086982971", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2086982971", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs2086982971", "url": "https://www.ncbi.nlm.nih.gov/snp/rs2086982971#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "KIKKKKKDDTYDKEKKSKKS", "down_seq": "FSKAGFTALNASKEKKKKKY", "snv": [ { "evidence": [ { "id": "rs2086982971", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2086982971" }, { "id": "rs2086982971", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs2086982971#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (KFS->NFS).", "chr_id": "16", "chr_pos": "4859954", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K219", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 13, "direction": "downstream", "id": "Q9NPG3-1.206.206", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9NPG3-1.270.270", "start_pos": 270, "end_pos": 270, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q9NPG3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "A", "start_aa": "A", "up_seq": "KKFQKEKEAQKKREEEHKPV", "down_seq": "VPSAEAQGLRELEGASDPLL", "snv": [ { "evidence": [ { "id": "Q9NPG3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3" } ], "glycoeffect": [], "subjects_tested": "1704", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "A", "sequence_mut": "V", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "16", "chr_pos": "4860801", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "A270", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9NPG3-1.312.312", "start_pos": 312, "end_pos": 312, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q9NPG3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LFGSTSDNDLLQAATAMDSL", "down_seq": "DLDLEHLLSESPEGSPFRDM", "snv": [ { "evidence": [ { "id": "Q9NPG3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "4177", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "T", "sequence_mut": "M", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "16", "chr_pos": "4860927", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "T312", "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 11, "direction": "upstream", "id": "Q9NPG3-1.323.323", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9NPG3-1.334.334", "start_pos": 334, "end_pos": 334, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs750500309", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs750500309", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs750500309", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs750500309", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs750500309", "url": "https://www.ncbi.nlm.nih.gov/snp/rs750500309#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs750500309", "url": "http://gnomad.broadinstitute.org/awesome?query=rs750500309", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "LDLEHLLSESPEGSPFRDMD", "down_seq": "GSDSLGVGLDQEFRQPSSLP", "snv": [ { "evidence": [ { "id": "rs750500309", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs750500309" }, { "id": "rs750500309", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs750500309" }, { "id": "rs750500309", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs750500309#frequency_tab" }, { "id": "rs750500309", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs750500309" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (DGS->NGS).", "chr_id": "16", "chr_pos": "4860992", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D334", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 11, "direction": "downstream", "id": "Q9NPG3-1.323.323", "categories": [ "phosphorylation_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q9NPG3-1.336.336", "categories": [ "snv_flag", "phosphorylation_flag" ] }, { "distance": 4, "direction": "upstream", "id": "Q9NPG3-1.338.338", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9NPG3-1.336.336", "start_pos": 336, "end_pos": 336, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "iPTMnet", "id": "Q9NPG3-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.", "journal": "Science signaling", "date": "2009", "authors": "Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" } ] }, { "title": "Motif-specific sampling of phosphoproteomes.", "journal": "Journal of proteome research", "date": "2008", "authors": "Ruse CI, McClatchy DB, Lu B, Cociorva D, Motoyama A, Park SK, Yates JR 3rd", "evidence": [ { "database": "iPTMnet", "id": "Q9NPG3-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3-1" } ], "reference": [ { "type": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "Q9NPG3-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3-1" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] } ], "crossref": [ { "id": "rs149384361", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs149384361", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs149384361", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs149384361", "database": "1000Genomes", "categories": [ "Other" ] }, { "id": "rs149384361", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs149384361", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs149384361", "url": "https://www.ncbi.nlm.nih.gov/snp/rs149384361#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs149384361", "url": "http://gnomad.broadinstitute.org/awesome?query=rs149384361", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "LEHLLSESPEGSPFRDMDDG", "down_seq": "DSLGVGLDQEFRQPSSLPEG", "snv": [ { "evidence": [ { "id": "rs149384361", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs149384361" }, { "id": "rs149384361", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs149384361" }, { "id": "rs149384361", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs149384361" }, { "id": "rs149384361", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs149384361#frequency_tab" }, { "id": "rs149384361", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs149384361" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (SDS->NDS).", "chr_id": "16", "chr_pos": "4860999", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "0.000196232", "site_lbl": "S336", "keywords": [ "ebi", "germline" ] } ], "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" }, { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" }, { "database": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ], "site_lbl": "Ser336" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "snv_flag", "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 13, "direction": "downstream", "id": "Q9NPG3-1.323.323", "categories": [ "phosphorylation_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q9NPG3-1.334.334", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q9NPG3-1.338.338", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.397.397", "start_pos": 397, "end_pos": 397, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q9NPG3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "A", "start_aa": "A", "up_seq": "GESRQKFFTQDINGILLDIE", "down_seq": "QTRELSSQVRSGVYAYLASF", "snv": [ { "evidence": [ { "id": "Q9NPG3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3" } ], "glycoeffect": [], "subjects_tested": "320", "subjects_positive": "1", "frequency": "0.3", "sequence_org": "A", "sequence_mut": "V", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "16", "chr_pos": "4870220", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "A397", "disease": [ { "disease_id": "DOID:4362", "recommended_name": { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervical cancer", "description": "A female reproductive organ cancer that is located_in the cervix." }, "synonyms": [ { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervical neoplasm", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervix cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervix uteri cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "neoplasm of uterine cervix", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "tumor of the Cervix Uteri", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer", "description": "A primary or metastatic malignant neoplasm involving the cervix." }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cancer of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer, somatic", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervix cancer", "description": "" }, { "id": "MIM:603956", "resource": "MIM", "url": "https://www.omim.org/entry/603956", "name": "Cervical cancer", "description": "Cervical cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "4362", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4362" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "3571", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3571" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9NPG3-1.465.465", "start_pos": 465, "end_pos": 465, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1350065127", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1350065127", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1350065127", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1350065127#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs1350065127", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1350065127", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "LQKLKEAIGRAMPEQMAKYQ", "down_seq": "ECQAHTQAKVAKMLEEEKDK", "snv": [ { "evidence": [ { "id": "rs1350065127", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1350065127" }, { "id": "rs1350065127", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1350065127#frequency_tab" }, { "id": "rs1350065127", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1350065127" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (DEC->NEC).", "chr_id": "16", "chr_pos": "4870597", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D465", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9NPG3-1.490.490", "start_pos": 490, "end_pos": 490, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q9NPG3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "HTQAKVAKMLEEEKDKEQRD", "down_seq": "ICSDEEEDEEKGGRRIMGPR", "snv": [ { "evidence": [ { "id": "Q9NPG3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3" } ], "glycoeffect": [], "subjects_tested": "1773", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "R", "sequence_mut": "Q", "comment": "Somatic mutation passed 1 filters: num. of cancers (4).", "chr_id": "16", "chr_pos": "4870882", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "R490", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematological tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "blood cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:0081452", "DOID:706", "DOID:1039", "DOID:5604", "DOID:6536", "DOID:0080638", "DOID:7757", "DOID:0050743", "DOID:4960", "DOID:8527", "DOID:1036", "DOID:5772" ], "evidence": [ { "id": "2531", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2531" } ] }, { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 3, "direction": "upstream", "id": "Q9NPG3-1.493.493", "categories": [ "phosphorylation_flag" ] }, { "distance": 20, "direction": "upstream", "id": "Q9NPG3-1.510.510", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9NPG3-1.510.510", "start_pos": 510, "end_pos": 510, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q9NPG3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "RICSDEEEDEEKGGRRIMGP", "down_seq": "KKFQWNDEIRELLCQVVKIK", "snv": [ { "evidence": [ { "id": "Q9NPG3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3" } ], "glycoeffect": [], "subjects_tested": "4177", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "Q", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "16", "chr_pos": "4870942", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "R510", "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 20, "direction": "downstream", "id": "Q9NPG3-1.490.490", "categories": [ "snv_flag" ] }, { "distance": 17, "direction": "downstream", "id": "Q9NPG3-1.493.493", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9NPG3-1.602.602", "start_pos": 602, "end_pos": 602, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q9NPG3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "LTSILAKKKVMAPSKIKVKE", "down_seq": "STKPDKKVSVPSGQIGGPIA", "snv": [ { "evidence": [ { "id": "Q9NPG3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "1773", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "S", "sequence_mut": "L", "comment": "Somatic mutation passed 1 filters: num. of cancers (5).", "chr_id": "16", "chr_pos": "4874215", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "S602", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 7, "direction": "upstream", "id": "Q9NPG3-1.609.609", "categories": [ "snv_flag" ] }, { "distance": 9, "direction": "upstream", "id": "Q9NPG3-1.611.611", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 12, "direction": "upstream", "id": "Q9NPG3-1.614.614", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9NPG3-1.609.609", "start_pos": 609, "end_pos": 609, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs2087773453", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2087773453", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs2087773453", "url": "https://www.ensembl.org/id/rs2087773453", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "KKVMAPSKIKVKESSTKPDK", "down_seq": "VSVPSGQIGGPIALPSDHQT", "snv": [ { "evidence": [ { "id": "rs2087773453", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2087773453" }, { "id": "rs2087773453", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs2087773453" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (KVS->NVS).", "chr_id": "16", "chr_pos": "4874237", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K609", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 7, "direction": "downstream", "id": "Q9NPG3-1.602.602", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q9NPG3-1.611.611", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 5, "direction": "upstream", "id": "Q9NPG3-1.614.614", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 18, "direction": "upstream", "id": "Q9NPG3-1.627.627", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9NPG3-1.627.627", "start_pos": 627, "end_pos": 627, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs746742247", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs746742247", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs746742247", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs746742247", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs746742247", "url": "https://www.ncbi.nlm.nih.gov/snp/rs746742247#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs746742247", "url": "http://gnomad.broadinstitute.org/awesome?query=rs746742247", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "H", "start_aa": "H", "up_seq": "DKKVSVPSGQIGGPIALPSD", "down_seq": "QTGGLSIGASSRELPSQASG", "snv": [ { "evidence": [ { "id": "rs746742247", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs746742247" }, { "id": "rs746742247", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs746742247" }, { "id": "rs746742247", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs746742247#frequency_tab" }, { "id": "rs746742247", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs746742247" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "H", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (HQT->NQT).", "chr_id": "16", "chr_pos": "4874289", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "H627", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 18, "direction": "downstream", "id": "Q9NPG3-1.609.609", "categories": [ "snv_flag" ] }, { "distance": 16, "direction": "downstream", "id": "Q9NPG3-1.611.611", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 13, "direction": "downstream", "id": "Q9NPG3-1.614.614", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9NPG3-1.783.783", "start_pos": 783, "end_pos": 783, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs373635271", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs373635271", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs373635271", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs373635271", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs373635271", "url": "https://www.ncbi.nlm.nih.gov/snp/rs373635271#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs373635271", "url": "http://gnomad.broadinstitute.org/awesome?query=rs373635271", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "H", "start_aa": "H", "up_seq": "LSCQAPLNKGLPEVHQSKAK", "down_seq": "HSLPRTSHGPQVAVPVPGPQ", "snv": [ { "evidence": [ { "id": "rs373635271", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs373635271" }, { "id": "rs373635271", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs373635271" }, { "id": "rs373635271", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs373635271#frequency_tab" }, { "id": "rs373635271", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs373635271" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "H", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (HHS->NHS).", "chr_id": "16", "chr_pos": "4874757", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "H783", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 7, "direction": "upstream", "id": "Q9NPG3-1.790.790", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9NPG3-1.86.86", "start_pos": 86, "end_pos": 86, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs760055198", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs760055198", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs760055198", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs760055198", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs760055198", "url": "https://www.ncbi.nlm.nih.gov/snp/rs760055198#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs760055198", "url": "http://gnomad.broadinstitute.org/awesome?query=rs760055198", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "ELVKNIRGKVKGLQPGDKKK", "down_seq": "LSDPFNDEEKERHKVEALAR", "snv": [ { "evidence": [ { "id": "rs760055198", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs760055198" }, { "id": "rs760055198", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs760055198" }, { "id": "rs760055198", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs760055198#frequency_tab" }, { "id": "rs760055198", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs760055198" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (DLS->NLS).", "chr_id": "16", "chr_pos": "4857996", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D86", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9NPG3-1.903.903", "start_pos": 903, "end_pos": 903, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs746762978", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs746762978", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs746762978", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs746762978", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs746762978", "url": "https://www.ncbi.nlm.nih.gov/snp/rs746762978#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs746762978", "url": "http://gnomad.broadinstitute.org/awesome?query=rs746762978", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "rs746762978", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs746762978", "database": "COSMIC", "categories": [ "Other" ] } ], "site_seq": "P", "start_aa": "P", "up_seq": "LSHPAKPHSVSSAGSSYKNN", "down_seq": "FASSISKHGVSSGSSSSGGT", "snv": [ { "evidence": [ { "id": "rs746762978", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs746762978" }, { "id": "rs746762978", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs746762978" }, { "id": "rs746762978", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs746762978#frequency_tab" }, { "id": "rs746762978", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs746762978" }, { "id": "rs746762978", "database": "COSMIC", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs746762978" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "P", "sequence_mut": "S", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (NNP->NNS).", "chr_id": "16", "chr_pos": "4875117", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P903", "keywords": [ "ebi", "somatic" ] }, { "evidence": [ { "id": "rs746762978", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs746762978" }, { "id": "rs746762978", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs746762978" }, { "id": "rs746762978", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs746762978#frequency_tab" }, { "id": "rs746762978", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs746762978" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "P", "sequence_mut": "T", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (NNP->NNT).", "chr_id": "16", "chr_pos": "4875117", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P903", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "Q9NPG3-1.884.884", "categories": [ "glycosylation_flag" ] }, { "distance": 12, "direction": "downstream", "id": "Q9NPG3-1.891.891", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 9, "direction": "downstream", "id": "Q9NPG3-1.894.894", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 6, "direction": "downstream", "id": "Q9NPG3-1.897.897", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 5, "direction": "downstream", "id": "Q9NPG3-1.898.898", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9NPG3-1.950.950", "start_pos": 950, "end_pos": 950, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "Q9NPG3", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "V", "start_aa": "V", "up_seq": "SGSLVPGIQPPSVGQATSRP", "down_seq": "PSSAGKKMPVSQKLTLVAPP", "snv": [ { "evidence": [ { "id": "Q9NPG3", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q9NPG3" } ], "glycoeffect": [], "subjects_tested": "1773", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "V", "sequence_mut": "I", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "16", "chr_pos": "4875258", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "V950", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "unlinked_id_list": [ "DOID:4765" ], "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9NPG3-1.1025.1025", "start_pos": 1025, "end_pos": 1025, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.", "journal": "Science signaling", "date": "2009", "authors": "Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" } ] } ], "crossref": [ { "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3", "database": "iPTMnet", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "TSLSKGASGTVLLAGSSLMA", "down_seq": "PYKSSSPKLSGAMSSNSLGI", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" }, { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" } ], "site_lbl": "Ser1025" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.166.166", "start_pos": 166, "end_pos": 166, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] } ], "crossref": [ { "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3", "database": "iPTMnet", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DELVPASLTTKYGGFYINSG", "down_seq": "LQFRQASESEDDFIKEKKKK", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" } ], "site_lbl": "Thr166" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 6, "direction": "downstream", "id": "Q9NPG3-1.160.160", "categories": [ "mutagenesis_flag" ] }, { "distance": 4, "direction": "downstream", "id": "Q9NPG3-1.162.162", "categories": [ "mutagenesis_flag" ] }, { "distance": 7, "direction": "upstream", "id": "Q9NPG3-1.173.173", "categories": [ "phosphorylation_flag" ] }, { "distance": 9, "direction": "upstream", "id": "Q9NPG3-1.175.175", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.173.173", "start_pos": 173, "end_pos": 173, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.", "journal": "Cell", "date": "2006", "authors": "Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "iPTMnet", "id": "Q9NPG3-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3-1" } ], "reference": [ { "type": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ] }, { "title": "Phosphoproteome analysis of the human Chang liver cells using SCX and a complementary mass spectrometric strategy.", "journal": "Proteomics", "date": "2008", "authors": "Sui S, Wang J, Yang B, Song L, Zhang J, Chen M, Liu J, Lu Z, Cai Y, Chen S, Bi W, Zhu Y, He F, Qian X", "evidence": [ { "database": "iPTMnet", "id": "Q9NPG3-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3-1" } ], "reference": [ { "type": "PubMed", "id": "18491316", "url": "https://glygen.org/publication/PubMed/18491316" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "Q9NPG3-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3-1" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "iPTMnet", "id": "Q9NPG3-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] } ], "crossref": [ { "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "18491316", "url": "https://glygen.org/publication/PubMed/18491316", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622", "database": "PubMed", "categories": [ "Other" ] }, { "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "LTTKYGGFYINSGTLQFRQA", "down_seq": "ESEDDFIKEKKKKSPKKRKL", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" }, { "database": "PubMed", "id": "18491316", "url": "https://glygen.org/publication/PubMed/18491316" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser173" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 13, "direction": "downstream", "id": "Q9NPG3-1.160.160", "categories": [ "mutagenesis_flag" ] }, { "distance": 11, "direction": "downstream", "id": "Q9NPG3-1.162.162", "categories": [ "mutagenesis_flag" ] }, { "distance": 7, "direction": "downstream", "id": "Q9NPG3-1.166.166", "categories": [ "phosphorylation_flag" ] }, { "distance": 2, "direction": "upstream", "id": "Q9NPG3-1.175.175", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.175.175", "start_pos": 175, "end_pos": 175, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.", "journal": "Cell", "date": "2006", "authors": "Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "iPTMnet", "id": "Q9NPG3-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3-1" } ], "reference": [ { "type": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "Q9NPG3-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3-1" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "iPTMnet", "id": "Q9NPG3-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] } ], "crossref": [ { "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622", "database": "PubMed", "categories": [ "Other" ] }, { "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "TKYGGFYINSGTLQFRQASE", "down_seq": "EDDFIKEKKKKSPKKRKLKE", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser175" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 15, "direction": "downstream", "id": "Q9NPG3-1.160.160", "categories": [ "mutagenesis_flag" ] }, { "distance": 13, "direction": "downstream", "id": "Q9NPG3-1.162.162", "categories": [ "mutagenesis_flag" ] }, { "distance": 9, "direction": "downstream", "id": "Q9NPG3-1.166.166", "categories": [ "phosphorylation_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q9NPG3-1.173.173", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.323.323", "start_pos": 323, "end_pos": 323, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] } ], "crossref": [ { "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3", "database": "iPTMnet", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "QAATAMDSLTDLDLEHLLSE", "down_seq": "PEGSPFRDMDDGSDSLGVGL", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" } ], "site_lbl": "Ser323" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 11, "direction": "downstream", "id": "Q9NPG3-1.312.312", "categories": [ "snv_flag" ] }, { "distance": 11, "direction": "upstream", "id": "Q9NPG3-1.334.334", "categories": [ "snv_flag" ] }, { "distance": 13, "direction": "upstream", "id": "Q9NPG3-1.336.336", "categories": [ "snv_flag", "phosphorylation_flag" ] }, { "distance": 15, "direction": "upstream", "id": "Q9NPG3-1.338.338", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.338.338", "start_pos": 338, "end_pos": 338, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "iPTMnet", "id": "Q9NPG3-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "Q9NPG3-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3-1" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] } ], "crossref": [ { "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "HLLSESPEGSPFRDMDDGSD", "down_seq": "LGVGLDQEFRQPSSLPEGLP", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ], "site_lbl": "Ser338" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 15, "direction": "downstream", "id": "Q9NPG3-1.323.323", "categories": [ "phosphorylation_flag" ] }, { "distance": 4, "direction": "downstream", "id": "Q9NPG3-1.334.334", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "downstream", "id": "Q9NPG3-1.336.336", "categories": [ "snv_flag", "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.493.493", "start_pos": 493, "end_pos": 493, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.", "journal": "Science signaling", "date": "2011", "authors": "Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" } ] }, { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] }, { "title": "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.", "journal": "Cell", "date": "2006", "authors": "Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "iPTMnet", "id": "Q9NPG3-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3-1" } ], "reference": [ { "type": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ] } ], "crossref": [ { "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692", "database": "PubMed", "categories": [ "Other" ] }, { "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "AKVAKMLEEEKDKEQRDRIC", "down_seq": "DEEEDEEKGGRRIMGPRKKF", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ], "site_lbl": "Ser493" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 3, "direction": "downstream", "id": "Q9NPG3-1.490.490", "categories": [ "snv_flag" ] }, { "distance": 17, "direction": "upstream", "id": "Q9NPG3-1.510.510", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.64.64", "start_pos": 64, "end_pos": 64, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "iPTMnet", "id": "Q9NPG3-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] } ], "crossref": [ { "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "Y", "start_aa": "Y", "up_seq": "AVRITLTLFEPDHKRCPEFF", "down_seq": "PELVKNIRGKVKGLQPGDKK", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Tyr64" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.660.660", "start_pos": 660, "end_pos": 660, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] }, { "title": "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.", "journal": "Science signaling", "date": "2009", "authors": "Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "iPTMnet", "id": "Q9NPG3-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Motif-specific sampling of phosphoproteomes.", "journal": "Journal of proteome research", "date": "2008", "authors": "Ruse CI, McClatchy DB, Lu B, Cociorva D, Motoyama A, Park SK, Yates JR 3rd", "evidence": [ { "database": "iPTMnet", "id": "Q9NPG3-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3-1" } ], "reference": [ { "type": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" } ] } ], "crossref": [ { "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332", "database": "PubMed", "categories": [ "Other" ] }, { "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "ELPSQASGGLANPPPVNLED", "down_seq": "LDEDLIRNPASSVEAVSKEL", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" }, { "database": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" } ], "site_lbl": "Ser660" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 17, "direction": "upstream", "id": "Q9NPG3-1.677.677", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.677.677", "start_pos": 677, "end_pos": 677, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.", "journal": "Science signaling", "date": "2009", "authors": "Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" } ], "reference": [ { "type": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" } ] } ], "crossref": [ { "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3", "database": "iPTMnet", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "LEDSLDEDLIRNPASSVEAV", "down_seq": "KELAALNSRAAGNSEFTLPA", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" }, { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" } ], "site_lbl": "Ser677" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 17, "direction": "downstream", "id": "Q9NPG3-1.660.660", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.818.818", "start_pos": 818, "end_pos": 818, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "iPTMnet", "id": "Q9NPG3-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] } ], "crossref": [ { "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PVPGPQVKVFHAGTQQQKNF", "down_seq": "PPSPFANKLQGPKASPTQCH", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Thr818" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 3, "direction": "upstream", "id": "Q9NPG3-1.821.821", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.821.821", "start_pos": 821, "end_pos": 821, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "iPTMnet", "id": "Q9NPG3-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] } ], "crossref": [ { "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "GPQVKVFHAGTQQQKNFTPP", "down_seq": "PFANKLQGPKASPTQCHRSL", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser821" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 3, "direction": "downstream", "id": "Q9NPG3-1.818.818", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.978.978", "start_pos": 978, "end_pos": 978, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Motif-specific sampling of phosphoproteomes.", "journal": "Journal of proteome research", "date": "2008", "authors": "Ruse CI, McClatchy DB, Lu B, Cociorva D, Motoyama A, Park SK, Yates JR 3rd", "evidence": [ { "database": "iPTMnet", "id": "Q9NPG3-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3-1" } ], "reference": [ { "type": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" } ] } ], "crossref": [ { "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "MPVSQKLTLVAPPGGPNGDS", "down_seq": "GGTQGVAKLLTSPSLKPSAV", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" }, { "database": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" } ], "site_lbl": "Ser978" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 3, "direction": "upstream", "id": "Q9NPG3-1.981.981", "categories": [ "phosphorylation_flag" ] }, { "distance": 11, "direction": "upstream", "id": "Q9NPG3-1.989.989", "categories": [ "glycosylation_flag" ] }, { "distance": 18, "direction": "upstream", "id": "Q9NPG3-1.996.996", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q9NPG3-1.981.981", "start_pos": 981, "end_pos": 981, "uniprot_canonical_ac": "Q9NPG3-1", "length": 1134, "uniprot_id": "UBN1_HUMAN", "protein_name": "Ubinuclein-1", "refseq_ac": "NP_001072982", "refseq_name": "ubinuclein-1 isoform a", "gene_name": "UBN1", "gene_names_uniprotkb": "UBN1", "gene_names_refseq": "UBN1; VT4; VT", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Motif-specific sampling of phosphoproteomes.", "journal": "Journal of proteome research", "date": "2008", "authors": "Ruse CI, McClatchy DB, Lu B, Cociorva D, Motoyama A, Park SK, Yates JR 3rd", "evidence": [ { "database": "iPTMnet", "id": "Q9NPG3-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3-1" } ], "reference": [ { "type": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" } ] } ], "crossref": [ { "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SQKLTLVAPPGGPNGDSSGG", "down_seq": "QGVAKLLTSPSLKPSAVSSV", "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q9NPG3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NPG3" }, { "database": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" } ], "site_lbl": "Thr981" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "1004", "end_pos": "1004" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "868", "end_pos": "868" }, { "start_pos": "869", "end_pos": "869" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "872", "end_pos": "872" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "884", "end_pos": "884" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "989", "end_pos": "989" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "138", "end_pos": "138" }, { "start_pos": "139", "end_pos": "139" }, { "start_pos": "140", "end_pos": "140" }, { "start_pos": "160", "end_pos": "160" }, { "start_pos": "162", "end_pos": "162" } ] }, { "type": "snv", "site_list": [ { "start_pos": "1000", "end_pos": "1000" }, { "start_pos": "1002", "end_pos": "1002" }, { "start_pos": "1003", "end_pos": "1003" }, { "start_pos": "206", "end_pos": "206" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "270", "end_pos": "270" }, { "start_pos": "312", "end_pos": "312" }, { "start_pos": "334", "end_pos": "334" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "397", "end_pos": "397" }, { "start_pos": "465", "end_pos": "465" }, { "start_pos": "490", "end_pos": "490" }, { "start_pos": "510", "end_pos": "510" }, { "start_pos": "602", "end_pos": "602" }, { "start_pos": "609", "end_pos": "609" }, { "start_pos": "611", "end_pos": "611" }, { "start_pos": "614", "end_pos": "614" }, { "start_pos": "627", "end_pos": "627" }, { "start_pos": "783", "end_pos": "783" }, { "start_pos": "790", "end_pos": "790" }, { "start_pos": "857", "end_pos": "857" }, { "start_pos": "861", "end_pos": "861" }, { "start_pos": "862", "end_pos": "862" }, { "start_pos": "866", "end_pos": "866" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "870", "end_pos": "870" }, { "start_pos": "875", "end_pos": "875" }, { "start_pos": "878", "end_pos": "878" }, { "start_pos": "879", "end_pos": "879" }, { "start_pos": "880", "end_pos": "880" }, { "start_pos": "881", "end_pos": "881" }, { "start_pos": "891", "end_pos": "891" }, { "start_pos": "894", "end_pos": "894" }, { "start_pos": "897", "end_pos": "897" }, { "start_pos": "898", "end_pos": "898" }, { "start_pos": "903", "end_pos": "903" }, { "start_pos": "950", "end_pos": "950" }, { "start_pos": "996", "end_pos": "996" }, { "start_pos": "999", "end_pos": "999" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1025", "end_pos": "1025" }, { "start_pos": "166", "end_pos": "166" }, { "start_pos": "173", "end_pos": "173" }, { "start_pos": "175", "end_pos": "175" }, { "start_pos": "323", "end_pos": "323" }, { "start_pos": "336", "end_pos": "336" }, { "start_pos": "338", "end_pos": "338" }, { "start_pos": "493", "end_pos": "493" }, { "start_pos": "64", "end_pos": "64" }, { "start_pos": "660", "end_pos": "660" }, { "start_pos": "677", "end_pos": "677" }, { "start_pos": "818", "end_pos": "818" }, { "start_pos": "821", "end_pos": "821" }, { "start_pos": "978", "end_pos": "978" }, { "start_pos": "981", "end_pos": "981" } ] } ], "categories": [ "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 3, "direction": "downstream", "id": "Q9NPG3-1.978.978", "categories": [ "phosphorylation_flag" ] }, { "distance": 8, "direction": "upstream", "id": "Q9NPG3-1.989.989", "categories": [ "glycosylation_flag" ] }, { "distance": 15, "direction": "upstream", "id": "Q9NPG3-1.996.996", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 18, "direction": "upstream", "id": "Q9NPG3-1.999.999", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 19, "direction": "upstream", "id": "Q9NPG3-1.1000.1000", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "O95760-1.144.144", "start_pos": 144, "end_pos": 144, "uniprot_canonical_ac": "O95760-1", "length": 270, "uniprot_id": "IL33_HUMAN", "protein_name": "Interleukin-33", "refseq_ac": "NP_001186569", "refseq_name": "interleukin-33 isoform b", "gene_name": "IL33", "gene_names_uniprotkb": "IL33; C9orf26; IL1F11; NFHEV", "gene_names_refseq": "C9orf26; DVS27; IL1F11; IL33; NF-HEV; NFEHEV", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95760", "url": "https://www.uniprot.org/uniprotkb/O95760" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Structural insights into the interaction of IL-33 with its receptors.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2013", "authors": "Liu X, Hammel M, He Y, Tainer JA, Jeng US, Zhang L, Wang S, Wang X", "evidence": [ { "database": "UniProtKB", "id": "O95760", "url": "https://www.uniprot.org/uniprotkb/O95760" } ], "reference": [ { "type": "PubMed", "id": "23980170", "url": "https://glygen.org/publication/PubMed/23980170" } ] } ], "crossref": [ { "id": "O95760", "url": "https://www.uniprot.org/uniprotkb/O95760", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "23980170", "url": "https://glygen.org/publication/PubMed/23980170", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "E", "start_aa": "E", "up_seq": "ASLSTYNDQSITFALEDESY", "down_seq": "IYVEDLKKDEKKDKVLLSYY", "mutagenesis": [ { "sequence_org": "E", "sequence_mut": "K", "comment": "Decreases affinity for IL1RL1.", "evidence": [ { "database": "UniProtKB", "id": "O95760", "url": "https://www.uniprot.org/uniprotkb/O95760" }, { "database": "PubMed", "id": "23980170", "url": "https://glygen.org/publication/PubMed/23980170" } ] } ], "all_sites": [ { "type": "mutagenesis", "site_list": [ { "start_pos": "144", "end_pos": "144" }, { "start_pos": "148", "end_pos": "148" }, { "start_pos": "149", "end_pos": "149" }, { "start_pos": "165", "end_pos": "165" }, { "start_pos": "244", "end_pos": "244" } ] }, { "type": "snv", "site_list": [ { "start_pos": "10", "end_pos": "10" }, { "start_pos": "152", "end_pos": "152" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "upstream", "id": "O95760-1.148.148", "categories": [ "mutagenesis_flag" ] }, { "distance": 5, "direction": "upstream", "id": "O95760-1.149.149", "categories": [ "mutagenesis_flag" ] }, { "distance": 8, "direction": "upstream", "id": "O95760-1.152.152", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "O95760-1.148.148", "start_pos": 148, "end_pos": 148, "uniprot_canonical_ac": "O95760-1", "length": 270, "uniprot_id": "IL33_HUMAN", "protein_name": "Interleukin-33", "refseq_ac": "NP_001186569", "refseq_name": "interleukin-33 isoform b", "gene_name": "IL33", "gene_names_uniprotkb": "IL33; C9orf26; IL1F11; NFHEV", "gene_names_refseq": "C9orf26; DVS27; IL1F11; IL33; NF-HEV; NFEHEV", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95760", "url": "https://www.uniprot.org/uniprotkb/O95760" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Structural insights into the interaction of IL-33 with its receptors.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2013", "authors": "Liu X, Hammel M, He Y, Tainer JA, Jeng US, Zhang L, Wang S, Wang X", "evidence": [ { "database": "UniProtKB", "id": "O95760", "url": "https://www.uniprot.org/uniprotkb/O95760" } ], "reference": [ { "type": "PubMed", "id": "23980170", "url": "https://glygen.org/publication/PubMed/23980170" } ] } ], "crossref": [ { "id": "O95760", "url": "https://www.uniprot.org/uniprotkb/O95760", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "23980170", "url": "https://glygen.org/publication/PubMed/23980170", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "E", "start_aa": "E", "up_seq": "TYNDQSITFALEDESYEIYV", "down_seq": "DLKKDEKKDKVLLSYYESQH", "mutagenesis": [ { "sequence_org": "E", "sequence_mut": "K", "comment": "7-fold decrease in affinity for IL1RL1.", "evidence": [ { "database": "UniProtKB", "id": "O95760", "url": "https://www.uniprot.org/uniprotkb/O95760" }, { "database": "PubMed", "id": "23980170", "url": "https://glygen.org/publication/PubMed/23980170" } ] } ], "all_sites": [ { "type": "mutagenesis", "site_list": [ { "start_pos": "144", "end_pos": "144" }, { "start_pos": "148", "end_pos": "148" }, { "start_pos": "149", "end_pos": "149" }, { "start_pos": "165", "end_pos": "165" }, { "start_pos": "244", "end_pos": "244" } ] }, { "type": "snv", "site_list": [ { "start_pos": "10", "end_pos": "10" }, { "start_pos": "152", "end_pos": "152" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "downstream", "id": "O95760-1.144.144", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "upstream", "id": "O95760-1.149.149", "categories": [ "mutagenesis_flag" ] }, { "distance": 4, "direction": "upstream", "id": "O95760-1.152.152", "categories": [ "snv_flag" ] }, { "distance": 17, "direction": "upstream", "id": "O95760-1.165.165", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "O95760-1.149.149", "start_pos": 149, "end_pos": 149, "uniprot_canonical_ac": "O95760-1", "length": 270, "uniprot_id": "IL33_HUMAN", "protein_name": "Interleukin-33", "refseq_ac": "NP_001186569", "refseq_name": "interleukin-33 isoform b", "gene_name": "IL33", "gene_names_uniprotkb": "IL33; C9orf26; IL1F11; NFHEV", "gene_names_refseq": "C9orf26; DVS27; IL1F11; IL33; NF-HEV; NFEHEV", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95760", "url": "https://www.uniprot.org/uniprotkb/O95760" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Structural insights into the interaction of IL-33 with its receptors.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2013", "authors": "Liu X, Hammel M, He Y, Tainer JA, Jeng US, Zhang L, Wang S, Wang X", "evidence": [ { "database": "UniProtKB", "id": "O95760", "url": "https://www.uniprot.org/uniprotkb/O95760" } ], "reference": [ { "type": "PubMed", "id": "23980170", "url": "https://glygen.org/publication/PubMed/23980170" } ] } ], "crossref": [ { "id": "O95760", "url": "https://www.uniprot.org/uniprotkb/O95760", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "23980170", "url": "https://glygen.org/publication/PubMed/23980170", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "YNDQSITFALEDESYEIYVE", "down_seq": "LKKDEKKDKVLLSYYESQHP", "mutagenesis": [ { "sequence_org": "D", "sequence_mut": "K", "comment": "Almost abolishes binding to IL1RL1.", "evidence": [ { "database": "UniProtKB", "id": "O95760", "url": "https://www.uniprot.org/uniprotkb/O95760" }, { "database": "PubMed", "id": "23980170", "url": "https://glygen.org/publication/PubMed/23980170" } ] } ], "all_sites": [ { "type": "mutagenesis", "site_list": [ { "start_pos": "144", "end_pos": "144" }, { "start_pos": "148", "end_pos": "148" }, { "start_pos": "149", "end_pos": "149" }, { "start_pos": "165", "end_pos": "165" }, { "start_pos": "244", "end_pos": "244" } ] }, { "type": "snv", "site_list": [ { "start_pos": "10", "end_pos": "10" }, { "start_pos": "152", "end_pos": "152" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 5, "direction": "downstream", "id": "O95760-1.144.144", "categories": [ "mutagenesis_flag" ] }, { "distance": 1, "direction": "downstream", "id": "O95760-1.148.148", "categories": [ "mutagenesis_flag" ] }, { "distance": 3, "direction": "upstream", "id": "O95760-1.152.152", "categories": [ "snv_flag" ] }, { "distance": 16, "direction": "upstream", "id": "O95760-1.165.165", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "O95760-1.165.165", "start_pos": 165, "end_pos": 165, "uniprot_canonical_ac": "O95760-1", "length": 270, "uniprot_id": "IL33_HUMAN", "protein_name": "Interleukin-33", "refseq_ac": "NP_001186569", "refseq_name": "interleukin-33 isoform b", "gene_name": "IL33", "gene_names_uniprotkb": "IL33; C9orf26; IL1F11; NFHEV", "gene_names_refseq": "C9orf26; DVS27; IL1F11; IL33; NF-HEV; NFEHEV", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95760", "url": "https://www.uniprot.org/uniprotkb/O95760" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Structural insights into the interaction of IL-33 with its receptors.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2013", "authors": "Liu X, Hammel M, He Y, Tainer JA, Jeng US, Zhang L, Wang S, Wang X", "evidence": [ { "database": "UniProtKB", "id": "O95760", "url": "https://www.uniprot.org/uniprotkb/O95760" } ], "reference": [ { "type": "PubMed", "id": "23980170", "url": "https://glygen.org/publication/PubMed/23980170" } ] } ], "crossref": [ { "id": "O95760", "url": "https://www.uniprot.org/uniprotkb/O95760", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "23980170", "url": "https://glygen.org/publication/PubMed/23980170", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "E", "start_aa": "E", "up_seq": "IYVEDLKKDEKKDKVLLSYY", "down_seq": "SQHPSNESGDGVDGKMLMVT", "mutagenesis": [ { "sequence_org": "E", "sequence_mut": "K", "comment": "8-fold decrease in affinity for IL1RL1.", "evidence": [ { "database": "UniProtKB", "id": "O95760", "url": "https://www.uniprot.org/uniprotkb/O95760" }, { "database": "PubMed", "id": "23980170", "url": "https://glygen.org/publication/PubMed/23980170" } ] } ], "all_sites": [ { "type": "mutagenesis", "site_list": [ { "start_pos": "144", "end_pos": "144" }, { "start_pos": "148", "end_pos": "148" }, { "start_pos": "149", "end_pos": "149" }, { "start_pos": "165", "end_pos": "165" }, { "start_pos": "244", "end_pos": "244" } ] }, { "type": "snv", "site_list": [ { "start_pos": "10", "end_pos": "10" }, { "start_pos": "152", "end_pos": "152" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 17, "direction": "downstream", "id": "O95760-1.148.148", "categories": [ "mutagenesis_flag" ] }, { "distance": 16, "direction": "downstream", "id": "O95760-1.149.149", "categories": [ "mutagenesis_flag" ] }, { "distance": 13, "direction": "downstream", "id": "O95760-1.152.152", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "O95760-1.244.244", "start_pos": 244, "end_pos": 244, "uniprot_canonical_ac": "O95760-1", "length": 270, "uniprot_id": "IL33_HUMAN", "protein_name": "Interleukin-33", "refseq_ac": "NP_001186569", "refseq_name": "interleukin-33 isoform b", "gene_name": "IL33", "gene_names_uniprotkb": "IL33; C9orf26; IL1F11; NFHEV", "gene_names_refseq": "C9orf26; DVS27; IL1F11; IL33; NF-HEV; NFEHEV", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95760", "url": "https://www.uniprot.org/uniprotkb/O95760" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Structural insights into the interaction of IL-33 with its receptors.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2013", "authors": "Liu X, Hammel M, He Y, Tainer JA, Jeng US, Zhang L, Wang S, Wang X", "evidence": [ { "database": "UniProtKB", "id": "O95760", "url": "https://www.uniprot.org/uniprotkb/O95760" } ], "reference": [ { "type": "PubMed", "id": "23980170", "url": "https://glygen.org/publication/PubMed/23980170" } ] } ], "crossref": [ { "id": "O95760", "url": "https://www.uniprot.org/uniprotkb/O95760", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "23980170", "url": "https://glygen.org/publication/PubMed/23980170", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "HSNCVSFECKTDPGVFIGVK", "down_seq": "NHLALIKVDSSENLCTENIL", "mutagenesis": [ { "sequence_org": "D", "sequence_mut": "K", "comment": "Decreases affinity for IL1RL1.", "evidence": [ { "database": "UniProtKB", "id": "O95760", "url": "https://www.uniprot.org/uniprotkb/O95760" }, { "database": "PubMed", "id": "23980170", "url": "https://glygen.org/publication/PubMed/23980170" } ] } ], "all_sites": [ { "type": "mutagenesis", "site_list": [ { "start_pos": "144", "end_pos": "144" }, { "start_pos": "148", "end_pos": "148" }, { "start_pos": "149", "end_pos": "149" }, { "start_pos": "165", "end_pos": "165" }, { "start_pos": "244", "end_pos": "244" } ] }, { "type": "snv", "site_list": [ { "start_pos": "10", "end_pos": "10" }, { "start_pos": "152", "end_pos": "152" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "O95760-1.10.10", "start_pos": 10, "end_pos": 10, "uniprot_canonical_ac": "O95760-1", "length": 270, "uniprot_id": "IL33_HUMAN", "protein_name": "Interleukin-33", "refseq_ac": "NP_001186569", "refseq_name": "interleukin-33 isoform b", "gene_name": "IL33", "gene_names_uniprotkb": "IL33; C9orf26; IL1F11; NFHEV", "gene_names_refseq": "C9orf26; DVS27; IL1F11; IL33; NF-HEV; NFEHEV", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95760", "url": "https://www.uniprot.org/uniprotkb/O95760" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95760", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95760", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "MKPKMKYST", "down_seq": "KISTAKWKNTASKALCFKLG", "snv": [ { "evidence": [ { "id": "O95760", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95760" } ], "glycoeffect": [], "subjects_tested": "92", "subjects_positive": "1", "frequency": "1.1", "sequence_org": "N", "sequence_mut": "S", "comment": "Somatic mutation passed 1 filters: patient freq. (1.1%).", "chr_id": "9", "chr_pos": "6241723", "ref_nt": "A", "alt_nt": "G", "minor_allelic_frequency": "", "site_lbl": "N10", "keywords": [ "biomuta", "somatic", "cancer" ] } ], "all_sites": [ { "type": "mutagenesis", "site_list": [ { "start_pos": "144", "end_pos": "144" }, { "start_pos": "148", "end_pos": "148" }, { "start_pos": "149", "end_pos": "149" }, { "start_pos": "165", "end_pos": "165" }, { "start_pos": "244", "end_pos": "244" } ] }, { "type": "snv", "site_list": [ { "start_pos": "10", "end_pos": "10" }, { "start_pos": "152", "end_pos": "152" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95760-1.152.152", "start_pos": 152, "end_pos": 152, "uniprot_canonical_ac": "O95760-1", "length": 270, "uniprot_id": "IL33_HUMAN", "protein_name": "Interleukin-33", "refseq_ac": "NP_001186569", "refseq_name": "interleukin-33 isoform b", "gene_name": "IL33", "gene_names_uniprotkb": "IL33; C9orf26; IL1F11; NFHEV", "gene_names_refseq": "C9orf26; DVS27; IL1F11; IL33; NF-HEV; NFEHEV", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95760", "url": "https://www.uniprot.org/uniprotkb/O95760" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95760", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95760", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "QSITFALEDESYEIYVEDLK", "down_seq": "DEKKDKVLLSYYESQHPSNE", "snv": [ { "evidence": [ { "id": "O95760", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95760" } ], "glycoeffect": [], "subjects_tested": "1773", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "K", "sequence_mut": "Q", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "9", "chr_pos": "6252976", "ref_nt": "A", "alt_nt": "C", "minor_allelic_frequency": "", "site_lbl": "K152", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "mutagenesis", "site_list": [ { "start_pos": "144", "end_pos": "144" }, { "start_pos": "148", "end_pos": "148" }, { "start_pos": "149", "end_pos": "149" }, { "start_pos": "165", "end_pos": "165" }, { "start_pos": "244", "end_pos": "244" } ] }, { "type": "snv", "site_list": [ { "start_pos": "10", "end_pos": "10" }, { "start_pos": "152", "end_pos": "152" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 8, "direction": "downstream", "id": "O95760-1.144.144", "categories": [ "mutagenesis_flag" ] }, { "distance": 4, "direction": "downstream", "id": "O95760-1.148.148", "categories": [ "mutagenesis_flag" ] }, { "distance": 3, "direction": "downstream", "id": "O95760-1.149.149", "categories": [ "mutagenesis_flag" ] }, { "distance": 13, "direction": "upstream", "id": "O95760-1.165.165", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "P35225-1.52.52", "start_pos": 52, "end_pos": 52, "uniprot_canonical_ac": "P35225-1", "length": 146, "uniprot_id": "IL13_HUMAN", "protein_name": "Interleukin-13", "refseq_ac": "NP_002179", "refseq_name": "interleukin-13 isoform 1 precursor", "gene_name": "IL13", "gene_names_uniprotkb": "IL13; NC30", "gene_names_refseq": "IL-13; IL13; P600", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P35225", "url": "https://www.uniprot.org/uniprotkb/P35225" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "P35225", "url": "https://www.uniprot.org/uniprotkb/P35225", "database": "UniProtKB", "categories": [ "Protein" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "ASPGPVPPSTALRELIEELV", "down_seq": "ITQNQKAPLCNGSMVWSINL", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn52", "evidence": [ { "id": "P35225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35225#ptm_processing" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "52", "end_pos": "52" }, { "start_pos": "63", "end_pos": "63" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "86", "end_pos": "86" } ] }, { "type": "snv", "site_list": [ { "start_pos": "107", "end_pos": "107" }, { "start_pos": "141", "end_pos": "141" }, { "start_pos": "3", "end_pos": "3" }, { "start_pos": "65", "end_pos": "65" }, { "start_pos": "69", "end_pos": "69" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "72", "end_pos": "72" }, { "start_pos": "73", "end_pos": "73" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "88", "end_pos": "88" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 11, "direction": "upstream", "id": "P35225-1.63.63", "categories": [ "glycosylation_flag" ] }, { "distance": 13, "direction": "upstream", "id": "P35225-1.65.65", "categories": [ "snv_flag" ] }, { "distance": 17, "direction": "upstream", "id": "P35225-1.69.69", "categories": [ "snv_flag" ] }, { "distance": 19, "direction": "upstream", "id": "P35225-1.71.71", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 20, "direction": "upstream", "id": "P35225-1.72.72", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "P35225-1.63.63", "start_pos": 63, "end_pos": 63, "uniprot_canonical_ac": "P35225-1", "length": 146, "uniprot_id": "IL13_HUMAN", "protein_name": "Interleukin-13", "refseq_ac": "NP_002179", "refseq_name": "interleukin-13 isoform 1 precursor", "gene_name": "IL13", "gene_names_uniprotkb": "IL13; NC30", "gene_names_refseq": "IL-13; IL13; P600", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P35225", "url": "https://www.uniprot.org/uniprotkb/P35225" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "P35225", "url": "https://www.uniprot.org/uniprotkb/P35225", "database": "UniProtKB", "categories": [ "Protein" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "LRELIEELVNITQNQKAPLC", "down_seq": "GSMVWSINLTAGMYCAALES", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn63", "evidence": [ { "id": "P35225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35225#ptm_processing" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "52", "end_pos": "52" }, { "start_pos": "63", "end_pos": "63" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "86", "end_pos": "86" } ] }, { "type": "snv", "site_list": [ { "start_pos": "107", "end_pos": "107" }, { "start_pos": "141", "end_pos": "141" }, { "start_pos": "3", "end_pos": "3" }, { "start_pos": "65", "end_pos": "65" }, { "start_pos": "69", "end_pos": "69" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "72", "end_pos": "72" }, { "start_pos": "73", "end_pos": "73" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "88", "end_pos": "88" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 11, "direction": "downstream", "id": "P35225-1.52.52", "categories": [ "glycosylation_flag" ] }, { "distance": 2, "direction": "upstream", "id": "P35225-1.65.65", "categories": [ "snv_flag" ] }, { "distance": 6, "direction": "upstream", "id": "P35225-1.69.69", "categories": [ "snv_flag" ] }, { "distance": 8, "direction": "upstream", "id": "P35225-1.71.71", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 9, "direction": "upstream", "id": "P35225-1.72.72", "categories": [ "snv_flag" ] }, { "distance": 10, "direction": "upstream", "id": "P35225-1.73.73", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "P35225-1.71.71", "start_pos": 71, "end_pos": 71, "uniprot_canonical_ac": "P35225-1", "length": 146, "uniprot_id": "IL13_HUMAN", "protein_name": "Interleukin-13", "refseq_ac": "NP_002179", "refseq_name": "interleukin-13 isoform 1 precursor", "gene_name": "IL13", "gene_names_uniprotkb": "IL13; NC30", "gene_names_refseq": "IL-13; IL13; P600", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P35225", "url": "https://www.uniprot.org/uniprotkb/P35225" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "P35225", "url": "https://www.uniprot.org/uniprotkb/P35225", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "rs1693556428", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1693556428", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1693556428", "url": "https://www.ensembl.org/id/rs1693556428", "database": "ENSEMBL", "categories": [ "Other" ] }, { "id": "rs765719901", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765719901", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs765719901", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765719901", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs765719901", "url": "https://www.ncbi.nlm.nih.gov/snp/rs765719901#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs765719901", "url": "http://gnomad.broadinstitute.org/awesome?query=rs765719901", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "VNITQNQKAPLCNGSMVWSI", "down_seq": "LTAGMYCAALESLINVSGCS", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn71", "evidence": [ { "id": "P35225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35225#ptm_processing" } ] } ], "snv": [ { "evidence": [ { "id": "rs1693556428", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1693556428" }, { "id": "rs1693556428", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1693556428" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "N", "sequence_mut": "K", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NLT->KLT).", "chr_id": "5", "chr_pos": "132659456", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N71", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs765719901", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765719901" }, { "id": "rs765719901", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765719901" }, { "id": "rs765719901", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs765719901#frequency_tab" }, { "id": "rs765719901", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs765719901" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NLT->SLT).", "chr_id": "5", "chr_pos": "132659455", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N71", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs765719901", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765719901" }, { "id": "rs765719901", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765719901" }, { "id": "rs765719901", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs765719901#frequency_tab" }, { "id": "rs765719901", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs765719901" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "N", "sequence_mut": "T", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NLT->TLT).", "chr_id": "5", "chr_pos": "132659455", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N71", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "52", "end_pos": "52" }, { "start_pos": "63", "end_pos": "63" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "86", "end_pos": "86" } ] }, { "type": "snv", "site_list": [ { "start_pos": "107", "end_pos": "107" }, { "start_pos": "141", "end_pos": "141" }, { "start_pos": "3", "end_pos": "3" }, { "start_pos": "65", "end_pos": "65" }, { "start_pos": "69", "end_pos": "69" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "72", "end_pos": "72" }, { "start_pos": "73", "end_pos": "73" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "88", "end_pos": "88" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "P35225-1.52.52", "categories": [ "glycosylation_flag" ] }, { "distance": 8, "direction": "downstream", "id": "P35225-1.63.63", "categories": [ "glycosylation_flag" ] }, { "distance": 6, "direction": "downstream", "id": "P35225-1.65.65", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "downstream", "id": "P35225-1.69.69", "categories": [ "snv_flag" ] }, { "distance": 1, "direction": "upstream", "id": "P35225-1.72.72", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "upstream", "id": "P35225-1.73.73", "categories": [ "snv_flag" ] }, { "distance": 15, "direction": "upstream", "id": "P35225-1.86.86", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 17, "direction": "upstream", "id": "P35225-1.88.88", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "P35225-1.86.86", "start_pos": 86, "end_pos": 86, "uniprot_canonical_ac": "P35225-1", "length": 146, "uniprot_id": "IL13_HUMAN", "protein_name": "Interleukin-13", "refseq_ac": "NP_002179", "refseq_name": "interleukin-13 isoform 1 precursor", "gene_name": "IL13", "gene_names_uniprotkb": "IL13; NC30", "gene_names_refseq": "IL-13; IL13; P600", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P35225", "url": "https://www.uniprot.org/uniprotkb/P35225" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "P35225", "url": "https://www.uniprot.org/uniprotkb/P35225", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "rs1554102313", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1554102313", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1554102313", "url": "https://www.ensembl.org/id/rs1554102313", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "MVWSINLTAGMYCAALESLI", "down_seq": "VSGCSAIEKTQRMLSGFCPH", "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn86", "evidence": [ { "id": "P35225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35225#ptm_processing" } ] } ], "snv": [ { "evidence": [ { "id": "rs1554102313", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1554102313" }, { "id": "rs1554102313", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1554102313" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "N", "sequence_mut": "I", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NVS->IVS).", "chr_id": "5", "chr_pos": "132659752", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N86", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "52", "end_pos": "52" }, { "start_pos": "63", "end_pos": "63" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "86", "end_pos": "86" } ] }, { "type": "snv", "site_list": [ { "start_pos": "107", "end_pos": "107" }, { "start_pos": "141", "end_pos": "141" }, { "start_pos": "3", "end_pos": "3" }, { "start_pos": "65", "end_pos": "65" }, { "start_pos": "69", "end_pos": "69" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "72", "end_pos": "72" }, { "start_pos": "73", "end_pos": "73" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "88", "end_pos": "88" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 17, "direction": "downstream", "id": "P35225-1.69.69", "categories": [ "snv_flag" ] }, { "distance": 15, "direction": "downstream", "id": "P35225-1.71.71", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 14, "direction": "downstream", "id": "P35225-1.72.72", "categories": [ "snv_flag" ] }, { "distance": 13, "direction": "downstream", "id": "P35225-1.73.73", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "upstream", "id": "P35225-1.88.88", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "P35225-1.107.107", "start_pos": 107, "end_pos": 107, "uniprot_canonical_ac": "P35225-1", "length": 146, "uniprot_id": "IL13_HUMAN", "protein_name": "Interleukin-13", "refseq_ac": "NP_002179", "refseq_name": "interleukin-13 isoform 1 precursor", "gene_name": "IL13", "gene_names_uniprotkb": "IL13; NC30", "gene_names_refseq": "IL-13; IL13; P600", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P35225", "url": "https://www.uniprot.org/uniprotkb/P35225" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1160695001", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1160695001", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1160695001", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1160695001#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "VSGCSAIEKTQRMLSGFCPH", "down_seq": "VSAGQFSSLHVRDTKIEVAQ", "snv": [ { "evidence": [ { "id": "rs1160695001", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1160695001" }, { "id": "rs1160695001", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1160695001#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (KVS->NVS).", "chr_id": "5", "chr_pos": "132659816", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K107", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "52", "end_pos": "52" }, { "start_pos": "63", "end_pos": "63" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "86", "end_pos": "86" } ] }, { "type": "snv", "site_list": [ { "start_pos": "107", "end_pos": "107" }, { "start_pos": "141", "end_pos": "141" }, { "start_pos": "3", "end_pos": "3" }, { "start_pos": "65", "end_pos": "65" }, { "start_pos": "69", "end_pos": "69" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "72", "end_pos": "72" }, { "start_pos": "73", "end_pos": "73" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "88", "end_pos": "88" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "P35225-1.88.88", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "P35225-1.141.141", "start_pos": 141, "end_pos": 141, "uniprot_canonical_ac": "P35225-1", "length": 146, "uniprot_id": "IL13_HUMAN", "protein_name": "Interleukin-13", "refseq_ac": "NP_002179", "refseq_name": "interleukin-13 isoform 1 precursor", "gene_name": "IL13", "gene_names_uniprotkb": "IL13; NC30", "gene_names_refseq": "IL-13; IL13; P600", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P35225", "url": "https://www.uniprot.org/uniprotkb/P35225" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "P35225", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/P35225", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "TKIEVAQFVKDLLLHLKKLF", "down_seq": "EGQFN", "snv": [ { "evidence": [ { "id": "P35225", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/P35225" } ], "glycoeffect": [], "subjects_tested": "2053", "subjects_positive": "4", "frequency": "0.2", "sequence_org": "R", "sequence_mut": "C", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "5", "chr_pos": "132660262", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "R141", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "52", "end_pos": "52" }, { "start_pos": "63", "end_pos": "63" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "86", "end_pos": "86" } ] }, { "type": "snv", "site_list": [ { "start_pos": "107", "end_pos": "107" }, { "start_pos": "141", "end_pos": "141" }, { "start_pos": "3", "end_pos": "3" }, { "start_pos": "65", "end_pos": "65" }, { "start_pos": "69", "end_pos": "69" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "72", "end_pos": "72" }, { "start_pos": "73", "end_pos": "73" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "88", "end_pos": "88" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "P35225-1.3.3", "start_pos": 3, "end_pos": 3, "uniprot_canonical_ac": "P35225-1", "length": 146, "uniprot_id": "IL13_HUMAN", "protein_name": "Interleukin-13", "refseq_ac": "NP_002179", "refseq_name": "interleukin-13 isoform 1 precursor", "gene_name": "IL13", "gene_names_uniprotkb": "IL13; NC30", "gene_names_refseq": "IL-13; IL13; P600", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P35225", "url": "https://www.uniprot.org/uniprotkb/P35225" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "P35225", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/P35225", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "P", "start_aa": "P", "up_seq": "MH", "down_seq": "LLNPLLLALGLMALLLTTVI", "snv": [ { "evidence": [ { "id": "P35225", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/P35225" } ], "glycoeffect": [], "subjects_tested": "720", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "P", "sequence_mut": "L", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "5", "chr_pos": "132658194", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "P3", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "52", "end_pos": "52" }, { "start_pos": "63", "end_pos": "63" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "86", "end_pos": "86" } ] }, { "type": "snv", "site_list": [ { "start_pos": "107", "end_pos": "107" }, { "start_pos": "141", "end_pos": "141" }, { "start_pos": "3", "end_pos": "3" }, { "start_pos": "65", "end_pos": "65" }, { "start_pos": "69", "end_pos": "69" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "72", "end_pos": "72" }, { "start_pos": "73", "end_pos": "73" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "88", "end_pos": "88" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "P35225-1.65.65", "start_pos": 65, "end_pos": 65, "uniprot_canonical_ac": "P35225-1", "length": 146, "uniprot_id": "IL13_HUMAN", "protein_name": "Interleukin-13", "refseq_ac": "NP_002179", "refseq_name": "interleukin-13 isoform 1 precursor", "gene_name": "IL13", "gene_names_uniprotkb": "IL13; NC30", "gene_names_refseq": "IL-13; IL13; P600", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P35225", "url": "https://www.uniprot.org/uniprotkb/P35225" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "P35225", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/P35225", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "ELIEELVNITQNQKAPLCNG", "down_seq": "MVWSINLTAGMYCAALESLI", "snv": [ { "evidence": [ { "id": "P35225", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/P35225" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "subjects_tested": "3601", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "N", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-loss (NGS->NGN).", "chr_id": "5", "chr_pos": "132659437", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "S65", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "52", "end_pos": "52" }, { "start_pos": "63", "end_pos": "63" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "86", "end_pos": "86" } ] }, { "type": "snv", "site_list": [ { "start_pos": "107", "end_pos": "107" }, { "start_pos": "141", "end_pos": "141" }, { "start_pos": "3", "end_pos": "3" }, { "start_pos": "65", "end_pos": "65" }, { "start_pos": "69", "end_pos": "69" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "72", "end_pos": "72" }, { "start_pos": "73", "end_pos": "73" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "88", "end_pos": "88" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 13, "direction": "downstream", "id": "P35225-1.52.52", "categories": [ "glycosylation_flag" ] }, { "distance": 2, "direction": "downstream", "id": "P35225-1.63.63", "categories": [ "glycosylation_flag" ] }, { "distance": 4, "direction": "upstream", "id": "P35225-1.69.69", "categories": [ "snv_flag" ] }, { "distance": 6, "direction": "upstream", "id": "P35225-1.71.71", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 7, "direction": "upstream", "id": "P35225-1.72.72", "categories": [ "snv_flag" ] }, { "distance": 8, "direction": "upstream", "id": "P35225-1.73.73", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "P35225-1.69.69", "start_pos": 69, "end_pos": 69, "uniprot_canonical_ac": "P35225-1", "length": 146, "uniprot_id": "IL13_HUMAN", "protein_name": "Interleukin-13", "refseq_ac": "NP_002179", "refseq_name": "interleukin-13 isoform 1 precursor", "gene_name": "IL13", "gene_names_uniprotkb": "IL13; NC30", "gene_names_refseq": "IL-13; IL13; P600", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P35225", "url": "https://www.uniprot.org/uniprotkb/P35225" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "P35225", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/P35225", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "ELVNITQNQKAPLCNGSMVW", "down_seq": "INLTAGMYCAALESLINVSG", "snv": [ { "evidence": [ { "id": "P35225", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/P35225" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "1773", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "S", "sequence_mut": "N", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "5", "chr_pos": "132659449", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "S69", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "52", "end_pos": "52" }, { "start_pos": "63", "end_pos": "63" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "86", "end_pos": "86" } ] }, { "type": "snv", "site_list": [ { "start_pos": "107", "end_pos": "107" }, { "start_pos": "141", "end_pos": "141" }, { "start_pos": "3", "end_pos": "3" }, { "start_pos": "65", "end_pos": "65" }, { "start_pos": "69", "end_pos": "69" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "72", "end_pos": "72" }, { "start_pos": "73", "end_pos": "73" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "88", "end_pos": "88" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 17, "direction": "downstream", "id": "P35225-1.52.52", "categories": [ "glycosylation_flag" ] }, { "distance": 6, "direction": "downstream", "id": "P35225-1.63.63", "categories": [ "glycosylation_flag" ] }, { "distance": 4, "direction": "downstream", "id": "P35225-1.65.65", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "upstream", "id": "P35225-1.71.71", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 3, "direction": "upstream", "id": "P35225-1.72.72", "categories": [ "snv_flag" ] }, { "distance": 4, "direction": "upstream", "id": "P35225-1.73.73", "categories": [ "snv_flag" ] }, { "distance": 17, "direction": "upstream", "id": "P35225-1.86.86", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 19, "direction": "upstream", "id": "P35225-1.88.88", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "P35225-1.72.72", "start_pos": 72, "end_pos": 72, "uniprot_canonical_ac": "P35225-1", "length": 146, "uniprot_id": "IL13_HUMAN", "protein_name": "Interleukin-13", "refseq_ac": "NP_002179", "refseq_name": "interleukin-13 isoform 1 precursor", "gene_name": "IL13", "gene_names_uniprotkb": "IL13; NC30", "gene_names_refseq": "IL-13; IL13; P600", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P35225", "url": "https://www.uniprot.org/uniprotkb/P35225" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs148077750", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148077750", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs148077750", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148077750", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs148077750", "url": "https://www.ncbi.nlm.nih.gov/snp/rs148077750#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs148077750", "url": "http://gnomad.broadinstitute.org/awesome?query=rs148077750", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "rs148077750", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs148077750", "database": "COSMIC", "categories": [ "Other" ] } ], "site_seq": "L", "start_aa": "L", "up_seq": "NITQNQKAPLCNGSMVWSIN", "down_seq": "TAGMYCAALESLINVSGCSA", "snv": [ { "evidence": [ { "id": "rs148077750", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148077750" }, { "id": "rs148077750", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148077750" }, { "id": "rs148077750", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs148077750#frequency_tab" }, { "id": "rs148077750", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs148077750" }, { "id": "rs148077750", "database": "COSMIC", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs148077750" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "L", "sequence_mut": "P", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-loss (NLT->NPT).", "chr_id": "5", "chr_pos": "132659458", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "L72", "keywords": [ "ebi", "somatic" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "52", "end_pos": "52" }, { "start_pos": "63", "end_pos": "63" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "86", "end_pos": "86" } ] }, { "type": "snv", "site_list": [ { "start_pos": "107", "end_pos": "107" }, { "start_pos": "141", "end_pos": "141" }, { "start_pos": "3", "end_pos": "3" }, { "start_pos": "65", "end_pos": "65" }, { "start_pos": "69", "end_pos": "69" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "72", "end_pos": "72" }, { "start_pos": "73", "end_pos": "73" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "88", "end_pos": "88" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 20, "direction": "downstream", "id": "P35225-1.52.52", "categories": [ "glycosylation_flag" ] }, { "distance": 9, "direction": "downstream", "id": "P35225-1.63.63", "categories": [ "glycosylation_flag" ] }, { "distance": 7, "direction": "downstream", "id": "P35225-1.65.65", "categories": [ "snv_flag" ] }, { "distance": 3, "direction": "downstream", "id": "P35225-1.69.69", "categories": [ "snv_flag" ] }, { "distance": 1, "direction": "downstream", "id": "P35225-1.71.71", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 1, "direction": "upstream", "id": "P35225-1.73.73", "categories": [ "snv_flag" ] }, { "distance": 14, "direction": "upstream", "id": "P35225-1.86.86", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 16, "direction": "upstream", "id": "P35225-1.88.88", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "P35225-1.73.73", "start_pos": 73, "end_pos": 73, "uniprot_canonical_ac": "P35225-1", "length": 146, "uniprot_id": "IL13_HUMAN", "protein_name": "Interleukin-13", "refseq_ac": "NP_002179", "refseq_name": "interleukin-13 isoform 1 precursor", "gene_name": "IL13", "gene_names_uniprotkb": "IL13; NC30", "gene_names_refseq": "IL-13; IL13; P600", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P35225", "url": "https://www.uniprot.org/uniprotkb/P35225" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1752105646", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1752105646", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1752105646", "url": "https://www.ensembl.org/id/rs1752105646", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ITQNQKAPLCNGSMVWSINL", "down_seq": "AGMYCAALESLINVSGCSAI", "snv": [ { "evidence": [ { "id": "rs1752105646", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1752105646" }, { "id": "rs1752105646", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1752105646" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NLT->NLI).", "chr_id": "5", "chr_pos": "132659461", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T73", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "52", "end_pos": "52" }, { "start_pos": "63", "end_pos": "63" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "86", "end_pos": "86" } ] }, { "type": "snv", "site_list": [ { "start_pos": "107", "end_pos": "107" }, { "start_pos": "141", "end_pos": "141" }, { "start_pos": "3", "end_pos": "3" }, { "start_pos": "65", "end_pos": "65" }, { "start_pos": "69", "end_pos": "69" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "72", "end_pos": "72" }, { "start_pos": "73", "end_pos": "73" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "88", "end_pos": "88" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 10, "direction": "downstream", "id": "P35225-1.63.63", "categories": [ "glycosylation_flag" ] }, { "distance": 8, "direction": "downstream", "id": "P35225-1.65.65", "categories": [ "snv_flag" ] }, { "distance": 4, "direction": "downstream", "id": "P35225-1.69.69", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "downstream", "id": "P35225-1.71.71", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 1, "direction": "downstream", "id": "P35225-1.72.72", "categories": [ "snv_flag" ] }, { "distance": 13, "direction": "upstream", "id": "P35225-1.86.86", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 15, "direction": "upstream", "id": "P35225-1.88.88", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "P35225-1.88.88", "start_pos": 88, "end_pos": 88, "uniprot_canonical_ac": "P35225-1", "length": 146, "uniprot_id": "IL13_HUMAN", "protein_name": "Interleukin-13", "refseq_ac": "NP_002179", "refseq_name": "interleukin-13 isoform 1 precursor", "gene_name": "IL13", "gene_names_uniprotkb": "IL13; NC30", "gene_names_refseq": "IL-13; IL13; P600", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P35225", "url": "https://www.uniprot.org/uniprotkb/P35225" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1752112025", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1752112025", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1752112025", "url": "https://www.ensembl.org/id/rs1752112025", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "WSINLTAGMYCAALESLINV", "down_seq": "GCSAIEKTQRMLSGFCPHKV", "snv": [ { "evidence": [ { "id": "rs1752112025", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1752112025" }, { "id": "rs1752112025", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1752112025" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "L", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NVS->NVL).", "chr_id": "5", "chr_pos": "132659758", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S88", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "52", "end_pos": "52" }, { "start_pos": "63", "end_pos": "63" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "86", "end_pos": "86" } ] }, { "type": "snv", "site_list": [ { "start_pos": "107", "end_pos": "107" }, { "start_pos": "141", "end_pos": "141" }, { "start_pos": "3", "end_pos": "3" }, { "start_pos": "65", "end_pos": "65" }, { "start_pos": "69", "end_pos": "69" }, { "start_pos": "71", "end_pos": "71" }, { "start_pos": "72", "end_pos": "72" }, { "start_pos": "73", "end_pos": "73" }, { "start_pos": "86", "end_pos": "86" }, { "start_pos": "88", "end_pos": "88" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "P35225-1.69.69", "categories": [ "snv_flag" ] }, { "distance": 17, "direction": "downstream", "id": "P35225-1.71.71", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 16, "direction": "downstream", "id": "P35225-1.72.72", "categories": [ "snv_flag" ] }, { "distance": 15, "direction": "downstream", "id": "P35225-1.73.73", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "downstream", "id": "P35225-1.86.86", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 19, "direction": "upstream", "id": "P35225-1.107.107", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "Q9H1X1-1.0.0", "start_pos": 0, "end_pos": 0, "uniprot_canonical_ac": "Q9H1X1-1", "length": 276, "uniprot_id": "RSPH9_HUMAN", "protein_name": "Radial spoke head protein 9 homolog", "refseq_ac": "NP_001180270", "refseq_name": "radial spoke head protein 9 homolog isoform 2", "gene_name": "RSPH9", "gene_names_uniprotkb": "RSPH9; C6orf206; MRPS18AL1", "gene_names_refseq": "C6orf206; CILD12; MRPS18AL1; RSPH9", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9H1X1", "url": "https://www.uniprot.org/uniprotkb/Q9H1X1" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9H1X1", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9H1X1" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] } ], "crossref": [ { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q9H1X1", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9H1X1", "database": "O-GlcNAc Database", "categories": [ "Other" ] } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "evidence": [ { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "Q9H1X1", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9H1X1" } ] } ], "all_sites": [], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "O95714-1.1370.1370", "start_pos": 1370, "end_pos": 1370, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "GLY_001151", "url": "https://data.glygen.org/GLY_001151", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "QIHYSYNEEKDEDHCSSPGG", "down_seq": "PASKSRLCSHRRALGDHSQA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1370", "evidence": [ { "id": "GLY_001151", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001151" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 8, "direction": "downstream", "id": "O95714-1.1362.1362", "categories": [ "snv_flag" ] }, { "distance": 16, "direction": "upstream", "id": "O95714-1.1386.1386", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1851.1851", "start_pos": 1851, "end_pos": 1851, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" }, { "database": "O-GlcNAc Atlas", "id": "O95714", "url": "https://oglcnac.org/atlas/detail/O95714" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Extracellular arginine availability modulates eIF2\u03b1 O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis.", "journal": "Journal of biomedical science", "date": "2023-05-22", "authors": "Hung Yu-Wen, Ouyang Ching, Ping Xiaoli, Qi Yue, Wang Yi-Chang, Kung Hsing-Jien, Ann David K", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" } ], "reference": [ { "type": "PubMed", "id": "37217939", "url": "https://glygen.org/publication/PubMed/37217939" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" }, { "database": "O-GlcNAc Atlas", "id": "O95714", "url": "https://oglcnac.org/atlas/detail/O95714" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] } ], "crossref": [ { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "37217939", "url": "https://glygen.org/publication/PubMed/37217939", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "O95714", "url": "https://oglcnac.org/atlas/detail/O95714", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "rs1263914415", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1263914415", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1263914415", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1263914415", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "rs749025739", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs749025739", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs749025739", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs749025739", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs749025739", "url": "https://www.ncbi.nlm.nih.gov/snp/rs749025739#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs749025739", "url": "http://gnomad.broadinstitute.org/awesome?query=rs749025739", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DMNASAQGASATVLEETRKE", "down_seq": "APVQLPVSGPELAAMMKIGT", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1851", "evidence": [ { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "O95714", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "O95714", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O95714" } ] } ], "snv": [ { "evidence": [ { "id": "rs1263914415", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1263914415" }, { "id": "rs1263914415", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1263914415" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (T->A).", "chr_id": "15", "chr_pos": "28222129", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T1851", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs749025739", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs749025739" }, { "id": "rs749025739", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs749025739" }, { "id": "rs749025739", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs749025739#frequency_tab" }, { "id": "rs749025739", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs749025739" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "T", "sequence_mut": "M", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (T->M).", "chr_id": "15", "chr_pos": "28222128", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T1851", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "O95714-1.2790.2790", "start_pos": 2790, "end_pos": 2790, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Site-Specific Profiling of Serum Glycoproteins Using N-Linked Glycan and Glycosite Analysis Revealing Atypical N-Glycosylation Sites on Albumin and alpha-1B-Glycoprotein.", "journal": "Analytical chemistry", "date": "2018", "authors": "Sun S, Hu Y, Jia L, Eshghi ST, Liu Y, Shah P, Zhang H", "evidence": [ { "database": "UniCarbKB", "id": "GLY_000040", "url": "http://data.glygen.org/GLY_000040" }, { "database": "GlyConnect", "id": "1191", "url": "https://glyconnect.expasy.org/browser/proteins/1191" } ], "reference": [ { "type": "PubMed", "id": "29671580", "url": "https://glygen.org/publication/PubMed/29671580" } ] }, { "title": "Deep quantitative glycoproteomics reveals gut microbiome induced remodeling of the brain glycoproteome", "journal": "bioRxiv", "date": "2023", "authors": "Potel C.M., Burtscher M.L., Garrido-Rodriguez M., Brauer-Nikonow A., Becher I., Typas A., Zimmermann M., Savitski M.", "evidence": [ { "database": "Data Submission", "id": "GLY_000888", "url": "http://data.glygen.org/GLY_000888" } ], "reference": [ { "type": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" } ] } ], "crossref": [ { "id": "29671580", "url": "https://glygen.org/publication/PubMed/29671580", "database": "PubMed", "categories": [ "Other" ] }, { "id": "1191", "url": "https://glyconnect.expasy.org/browser/proteins/1191", "database": "GlyConnect", "categories": [ "Glycomics", "Glycoproteomics" ] }, { "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529", "database": "DOI", "categories": [ "Other" ] }, { "id": "GLY_000888", "url": "http://data.glygen.org/GLY_000888", "database": "Data Submission", "categories": [ "Other" ] }, { "id": "GLY_000040", "url": "http://data.glygen.org/GLY_000040", "database": "UniCarbKB", "categories": [] } ], "site_seq": "N", "start_aa": "N", "up_seq": "CHSSQPGMLLDSWSRMVKSL", "down_seq": "VSSSVNQASRLIDGSEPCWQ", "glycosylation": [ { "glytoucan_ac": "G06356OH", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn2790", "evidence": [ { "id": "29671580", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29671580" }, { "id": "1191", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1191" } ] }, { "glytoucan_ac": "G27058EU", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "SLNVSSSVNQASRLIDGSEPCWQSSGSQGK", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn2790", "evidence": [ { "id": "10.1101/2023.09.13.557529", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "id": "GLY_000888", "database": "Data Submission", "url": "http://data.glygen.org/GLY_000888" } ] }, { "glytoucan_ac": "G59626AS", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn2790", "evidence": [ { "id": "29671580", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29671580" }, { "id": "GLY_000040", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000040" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 9, "direction": "downstream", "id": "O95714-1.2781.2781", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "upstream", "id": "O95714-1.2792.2792", "categories": [ "snv_flag" ] }, { "distance": 8, "direction": "upstream", "id": "O95714-1.2798.2798", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 3 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycans", "count": 3 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 3 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycans", "count": 3 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "O95714-1.3136.3136", "start_pos": 3136, "end_pos": 3136, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Deep quantitative glycoproteomics reveals gut microbiome induced remodeling of the brain glycoproteome", "journal": "bioRxiv", "date": "2023", "authors": "Potel C.M., Burtscher M.L., Garrido-Rodriguez M., Brauer-Nikonow A., Becher I., Typas A., Zimmermann M., Savitski M.", "evidence": [ { "database": "Data Submission", "id": "GLY_000888", "url": "http://data.glygen.org/GLY_000888" } ], "reference": [ { "type": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" } ] } ], "crossref": [ { "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529", "database": "DOI", "categories": [ "Other" ] }, { "id": "GLY_000888", "url": "http://data.glygen.org/GLY_000888", "database": "Data Submission", "categories": [ "Other" ] }, { "id": "rs1319009134", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1319009134", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1319009134", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1319009134", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "SSGELYTWGLGEYGRLGHGD", "down_seq": "TTQLKPKMVKVLLGHRVIQV", "glycosylation": [ { "glytoucan_ac": "G62765YT", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "LGHGDNTTQLK", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn3136", "evidence": [ { "id": "10.1101/2023.09.13.557529", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "id": "GLY_000888", "database": "Data Submission", "url": "http://data.glygen.org/GLY_000888" } ] } ], "snv": [ { "evidence": [ { "id": "rs1319009134", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1319009134" }, { "id": "rs1319009134", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1319009134" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "N", "sequence_mut": "D", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NTT->DTT).", "chr_id": "15", "chr_pos": "28176976", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N3136", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "O95714-1.3331.3331", "start_pos": 3331, "end_pos": 3331, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "GLY_001151", "url": "https://data.glygen.org/GLY_001151", "database": "GlyGen", "categories": [ "Other" ] }, { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs140440992", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs140440992", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs140440992", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs140440992", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs140440992", "url": "http://gnomad.broadinstitute.org/awesome?query=rs140440992", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ITRVACGSSHSVAWTTVDVA", "down_seq": "PSVHEPVLFQTARDPLGASY", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3331", "evidence": [ { "id": "GLY_001151", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001151" } ] } ], "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" }, { "id": "rs140440992", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs140440992" }, { "id": "rs140440992", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs140440992" }, { "id": "rs140440992", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs140440992" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "4484", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "T", "sequence_mut": "M", "comment": "Somatic mutation passed 1 filters: o-glyco-site-loss (T->M).", "chr_id": "15", "chr_pos": "28174460", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "T3331", "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:0081203", "recommended_name": { "id": "DOID:0081203", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0081203", "name": "autosomal recessive intellectual developmental disorder 38", "description": "An autosomal recessive intellectual developmental disorder that has_material_basis_in homozygous mutation in the HERC2 gene on chromosome 15q13." }, "synonyms": [ { "id": "MONDO:0014224", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014224", "name": "developmental delay with autism spectrum disorder and gait instability", "description": "Developmental delay with autism spectrum disorder and gait instability is a rare, genetic, neurological disorder characterized by infant hypotonia and feeding difficulties, global development delay, mild to moderated intellectual disability, delayed independent ambulation, broad-based gait with arms upheld and flexed at the elbow with brisk walking or running, and limited language skills. Behavior patterns are highly variable and range from sociable and affectionate to autistic behavior." }, { "id": "MONDO:0014224", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014224", "name": "developmental delay with ASD and gait instability", "description": "" }, { "id": "MONDO:0014224", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014224", "name": "intellectual developmental disorder, autosomal recessive 38", "description": "" }, { "id": "MONDO:0014224", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014224", "name": "intellectual disability, autosomal recessive type 38", "description": "" }, { "id": "MONDO:0014224", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014224", "name": "mental retardation, autosomal recessive type 38", "description": "" }, { "id": "MONDO:0014224", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014224", "name": "MRT38", "description": "" }, { "id": "MONDO:0014224", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014224", "name": "intellectual disability, autosomal recessive 38", "description": "" }, { "id": "MONDO:0014224", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014224", "name": "mental retardation, autosomal recessive 38", "description": "" }, { "id": "MIM:615516", "resource": "MIM", "url": "https://www.omim.org/entry/615516", "name": "Intellectual developmental disorder, autosomal recessive 38", "description": "Intellectual developmental disorder, autosomal recessive 38" } ], "unlinked_id_list": [], "evidence": [ { "id": "615516", "database": "MIM", "url": "https://www.omim.org/entry/615516" }, { "id": "0081203", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0081203" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 18, "direction": "downstream", "id": "O95714-1.3313.3313", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3475.3475", "start_pos": 3475, "end_pos": 3475, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" }, { "database": "O-GlcNAc Atlas", "id": "O95714", "url": "https://oglcnac.org/atlas/detail/O95714" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Extracellular arginine availability modulates eIF2\u03b1 O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis.", "journal": "Journal of biomedical science", "date": "2023-05-22", "authors": "Hung Yu-Wen, Ouyang Ching, Ping Xiaoli, Qi Yue, Wang Yi-Chang, Kung Hsing-Jien, Ann David K", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" } ], "reference": [ { "type": "PubMed", "id": "37217939", "url": "https://glygen.org/publication/PubMed/37217939" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" }, { "database": "O-GlcNAc Atlas", "id": "O95714", "url": "https://oglcnac.org/atlas/detail/O95714" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] } ], "crossref": [ { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "37217939", "url": "https://glygen.org/publication/PubMed/37217939", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "O95714", "url": "https://oglcnac.org/atlas/detail/O95714", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs148150960", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148150960", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs148150960", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs148150960", "database": "1000Genomes", "categories": [ "Other" ] }, { "id": "rs148150960", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148150960", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs148150960", "url": "https://www.ncbi.nlm.nih.gov/snp/rs148150960#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs148150960", "url": "http://gnomad.broadinstitute.org/awesome?query=rs148150960", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "VDIEDRLSPNPWQEKREIVS", "down_seq": "EDAVTPSAVTPSAPSASARP", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser3475", "evidence": [ { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "O95714", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "O95714", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O95714" } ] } ], "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" }, { "id": "rs148150960", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148150960" }, { "id": "rs148150960", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs148150960" }, { "id": "rs148150960", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148150960" }, { "id": "rs148150960", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs148150960#frequency_tab" }, { "id": "rs148150960", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs148150960" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "4484", "subjects_positive": "2", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "F", "comment": "Somatic mutation passed 1 filters: o-glyco-site-loss (S->F).", "chr_id": "15", "chr_pos": "28167817", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "S3475", "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:11983", "recommended_name": { "id": "DOID:11983", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11983", "name": "Prader-Willi syndrome", "description": "A chromosomal disease that is characterized by weak muscle tone, feeding difficulties, poor growth, and delayed development. Beginning in childhood, affected individuals develop an insatiable appetite, which leads to chronic overeating and obesity." }, "synonyms": [ { "id": "DOID:11983", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11983", "name": "Prader Willi syndrome", "description": "" }, { "id": "MONDO:0008300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008300", "name": "Prader-Willi syndrome", "description": "Prader-Willi syndrome is a rare genetic disorder characterized by hypothalamic-pituitary abnormalities with severe hypotonia during the neonatal period and first two years of life and the onset of hyperphagia with a risk of morbid obesity during infancy and adulthood, learning difficulties and behavioral problems or severe psychiatric problems." }, { "id": "MONDO:0008300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008300", "name": "Prader-Labhart-Willi syndrome", "description": "" }, { "id": "MONDO:0008300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008300", "name": "Prader-Willi syndrome", "description": "" }, { "id": "MONDO:0008300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008300", "name": "Prader-Willi-Labhart syndrome", "description": "" }, { "id": "MONDO:0008300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008300", "name": "Willi-Prader syndrome", "description": "" }, { "id": "MONDO:0008300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008300", "name": "PWS", "description": "" }, { "id": "MONDO:0008300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008300", "name": "obesity, muscular hypotonia, intellectual disability, short stature, hypogonadotropic hypogonadism, and small hands and feet", "description": "" }, { "id": "MONDO:0008300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008300", "name": "obesity, muscular hypotonia, mental retardation, short stature, hypogonadotropic hypogonadism, and small hands and feet", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "11983", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11983" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 10, "direction": "upstream", "id": "O95714-1.3485.3485", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 12, "direction": "upstream", "id": "O95714-1.3487.3487", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "O95714-1.3485.3485", "start_pos": 3485, "end_pos": 3485, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "GLY_001151", "url": "https://data.glygen.org/GLY_001151", "database": "GlyGen", "categories": [ "Other" ] }, { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "PWQEKREIVSSEDAVTPSAV", "down_seq": "PSAPSASARPFIPVTDDLGA", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3485", "evidence": [ { "id": "GLY_001151", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001151" } ] } ], "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "2053", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "T", "sequence_mut": "I", "comment": "Somatic mutation passed 1 filters: o-glyco-site-loss (T->I).", "chr_id": "15", "chr_pos": "28167787", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "T3485", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 10, "direction": "downstream", "id": "O95714-1.3475.3475", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 2, "direction": "upstream", "id": "O95714-1.3487.3487", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3487.3487", "start_pos": 3487, "end_pos": 3487, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" }, { "database": "O-GlcNAc Atlas", "id": "O95714", "url": "https://oglcnac.org/atlas/detail/O95714" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Extracellular arginine availability modulates eIF2\u03b1 O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis.", "journal": "Journal of biomedical science", "date": "2023-05-22", "authors": "Hung Yu-Wen, Ouyang Ching, Ping Xiaoli, Qi Yue, Wang Yi-Chang, Kung Hsing-Jien, Ann David K", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" } ], "reference": [ { "type": "PubMed", "id": "37217939", "url": "https://glygen.org/publication/PubMed/37217939" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" }, { "database": "O-GlcNAc Atlas", "id": "O95714", "url": "https://oglcnac.org/atlas/detail/O95714" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] } ], "crossref": [ { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "37217939", "url": "https://glygen.org/publication/PubMed/37217939", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "O95714", "url": "https://oglcnac.org/atlas/detail/O95714", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs146303265", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs146303265", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs146303265", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs146303265", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs146303265", "url": "https://www.ncbi.nlm.nih.gov/snp/rs146303265#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs146303265", "url": "http://gnomad.broadinstitute.org/awesome?query=rs146303265", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "rs772814784", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs772814784", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs772814784", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs772814784", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs772814784", "url": "https://www.ncbi.nlm.nih.gov/snp/rs772814784#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs772814784", "url": "http://gnomad.broadinstitute.org/awesome?query=rs772814784", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "QEKREIVSSEDAVTPSAVTP", "down_seq": "APSASARPFIPVTDDLGAAS", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser3487", "evidence": [ { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "O95714", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "O95714", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O95714" } ] } ], "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" }, { "id": "rs146303265", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs146303265" }, { "id": "rs146303265", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs146303265" }, { "id": "rs146303265", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs146303265#frequency_tab" }, { "id": "rs146303265", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs146303265" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "720", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "S", "sequence_mut": "L", "comment": "Somatic mutation passed 2 filters: num. of cancers (3); o-glyco-site-loss (S->L).", "chr_id": "15", "chr_pos": "28167781", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "S3487", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] }, { "evidence": [ { "id": "rs772814784", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs772814784" }, { "id": "rs772814784", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs772814784" }, { "id": "rs772814784", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs772814784#frequency_tab" }, { "id": "rs772814784", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs772814784" } ], "glycoeffect": [ "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "P", "comment": "Germline mutation passed 1 filters: o-glyco-site-loss (S->P).", "chr_id": "15", "chr_pos": "28167782", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S3487", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 12, "direction": "downstream", "id": "O95714-1.3475.3475", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 2, "direction": "downstream", "id": "O95714-1.3485.3485", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "O95714-1.3746.3746", "start_pos": 3746, "end_pos": 3746, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Deep quantitative glycoproteomics reveals gut microbiome induced remodeling of the brain glycoproteome", "journal": "bioRxiv", "date": "2023", "authors": "Potel C.M., Burtscher M.L., Garrido-Rodriguez M., Brauer-Nikonow A., Becher I., Typas A., Zimmermann M., Savitski M.", "evidence": [ { "database": "Data Submission", "id": "GLY_000888", "url": "http://data.glygen.org/GLY_000888" } ], "reference": [ { "type": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" } ] }, { "title": "Reanalysis of Global Proteomic and Phosphoproteomic Data Identified a Large Number of Glycopeptides.", "journal": "Analytical chemistry", "date": "2018", "authors": "Hu Y, Shah P, Clark DJ, Ao M, Zhang H", "evidence": [ { "database": "GlyConnect", "id": "1191", "url": "https://glyconnect.expasy.org/browser/proteins/1191" } ], "reference": [ { "type": "PubMed", "id": "29741879", "url": "https://glygen.org/publication/PubMed/29741879" } ] } ], "crossref": [ { "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529", "database": "DOI", "categories": [ "Other" ] }, { "id": "GLY_000888", "url": "http://data.glygen.org/GLY_000888", "database": "Data Submission", "categories": [ "Other" ] }, { "id": "29741879", "url": "https://glygen.org/publication/PubMed/29741879", "database": "PubMed", "categories": [ "Other" ] }, { "id": "1191", "url": "https://glyconnect.expasy.org/browser/proteins/1191", "database": "GlyConnect", "categories": [ "Glycomics", "Glycoproteomics" ] }, { "id": "rs114532098", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs114532098", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs114532098", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs114532098", "database": "1000Genomes", "categories": [ "Other" ] }, { "id": "rs114532098", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs114532098", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs114532098", "url": "https://www.ncbi.nlm.nih.gov/snp/rs114532098#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs114532098", "url": "http://gnomad.broadinstitute.org/awesome?query=rs114532098", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "rs1480398247", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1480398247", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1480398247", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1480398247", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "SCPSMDLVTCLLDFRLNLAS", "down_seq": "RSIVPRLAASLAACAQLSAL", "glycosylation": [ { "glytoucan_ac": "G02815KT", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "LNLASNR", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn3746", "evidence": [ { "id": "10.1101/2023.09.13.557529", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "id": "GLY_000888", "database": "Data Submission", "url": "http://data.glygen.org/GLY_000888" } ] }, { "glytoucan_ac": "G39188ZX", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn3746", "evidence": [ { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" }, { "id": "1191", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1191" } ] } ], "snv": [ { "evidence": [ { "id": "rs114532098", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs114532098" }, { "id": "rs114532098", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs114532098" }, { "id": "rs114532098", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs114532098" }, { "id": "rs114532098", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs114532098#frequency_tab" }, { "id": "rs114532098", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs114532098" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "N", "sequence_mut": "K", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NRS->KRS).", "chr_id": "15", "chr_pos": "28144138", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "0.00294349", "site_lbl": "N3746", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1480398247", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1480398247" }, { "id": "rs1480398247", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1480398247" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "N", "sequence_mut": "T", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NRS->TRS).", "chr_id": "15", "chr_pos": "28144139", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N3746", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "downstream", "id": "O95714-1.3744.3744", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "upstream", "id": "O95714-1.3748.3748", "categories": [ "snv_flag" ] }, { "distance": 8, "direction": "upstream", "id": "O95714-1.3754.3754", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 2 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycans", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 2 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycans", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "O95714-1.4022.4022", "start_pos": 4022, "end_pos": 4022, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "GLY_001151", "url": "https://data.glygen.org/GLY_001151", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ADGKLYATGYGAGGRLGIGG", "down_seq": "ESVSTPTLLESIQHVFIKKV", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr4022", "evidence": [ { "id": "GLY_001151", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001151" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 7, "direction": "upstream", "id": "O95714-1.4029.4029", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.4075.4075", "start_pos": 4075, "end_pos": 4075, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Deep quantitative glycoproteomics reveals gut microbiome induced remodeling of the brain glycoproteome", "journal": "bioRxiv", "date": "2023", "authors": "Potel C.M., Burtscher M.L., Garrido-Rodriguez M., Brauer-Nikonow A., Becher I., Typas A., Zimmermann M., Savitski M.", "evidence": [ { "database": "Data Submission", "id": "GLY_000888", "url": "http://data.glygen.org/GLY_000888" } ], "reference": [ { "type": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" } ] } ], "crossref": [ { "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529", "database": "DOI", "categories": [ "Other" ] }, { "id": "GLY_000888", "url": "http://data.glygen.org/GLY_000888", "database": "Data Submission", "categories": [ "Other" ] }, { "id": "rs780656191", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs780656191", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs780656191", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs780656191", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs780656191", "url": "https://www.ncbi.nlm.nih.gov/snp/rs780656191#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs780656191", "url": "http://gnomad.broadinstitute.org/awesome?query=rs780656191", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "rs1390479912", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1390479912", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1390479912", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1390479912#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs1390479912", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1390479912", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "SSEGEVYSWGEAEDGKLGHG", "down_seq": "RSPCDRPRVIESLRGIEVVD", "glycosylation": [ { "glytoucan_ac": "G62765YT", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "LGHGNRSPCDRPR", "relation": "attached", "comment": "", "icn3d_view": {}, "start_aa": "Asn", "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn4075", "evidence": [ { "id": "10.1101/2023.09.13.557529", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "id": "GLY_000888", "database": "Data Submission", "url": "http://data.glygen.org/GLY_000888" } ] } ], "snv": [ { "evidence": [ { "id": "rs780656191", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs780656191" }, { "id": "rs780656191", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs780656191" }, { "id": "rs780656191", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs780656191#frequency_tab" }, { "id": "rs780656191", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs780656191" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "N", "sequence_mut": "D", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NRS->DRS).", "chr_id": "15", "chr_pos": "28135485", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N4075", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs780656191", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs780656191" }, { "id": "rs780656191", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs780656191" }, { "id": "rs780656191", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs780656191#frequency_tab" }, { "id": "rs780656191", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs780656191" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "N", "sequence_mut": "H", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NRS->HRS).", "chr_id": "15", "chr_pos": "28135485", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N4075", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1390479912", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1390479912" }, { "id": "rs1390479912", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1390479912#frequency_tab" }, { "id": "rs1390479912", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1390479912" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_org": "N", "sequence_mut": "K", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NRS->KRS).", "chr_id": "15", "chr_pos": "28135483", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N4075", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "upstream", "id": "O95714-1.4077.4077", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_n_linked_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_n_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "O95714-1.4182.4182", "start_pos": 4182, "end_pos": 4182, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" }, { "database": "O-GlcNAc Atlas", "id": "O95714", "url": "https://oglcnac.org/atlas/detail/O95714" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Extracellular arginine availability modulates eIF2\u03b1 O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis.", "journal": "Journal of biomedical science", "date": "2023-05-22", "authors": "Hung Yu-Wen, Ouyang Ching, Ping Xiaoli, Qi Yue, Wang Yi-Chang, Kung Hsing-Jien, Ann David K", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" } ], "reference": [ { "type": "PubMed", "id": "37217939", "url": "https://glygen.org/publication/PubMed/37217939" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" }, { "database": "O-GlcNAc Atlas", "id": "O95714", "url": "https://oglcnac.org/atlas/detail/O95714" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] } ], "crossref": [ { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "37217939", "url": "https://glygen.org/publication/PubMed/37217939", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "O95714", "url": "https://oglcnac.org/atlas/detail/O95714", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "DDDTVWSWGDGDYGKLGRGG", "down_seq": "DGCKVPMKIDSLTGLGVVKV", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Ser", "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser4182", "evidence": [ { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "O95714", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "O95714", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O95714" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "glycosylation_flag" ], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 1, "direction": "upstream", "id": "O95714-1.4183.4183", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": false, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "O95714-1.995.995", "start_pos": 995, "end_pos": 995, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" }, { "database": "O-GlcNAc Atlas", "id": "O95714", "url": "https://oglcnac.org/atlas/detail/O95714" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Extracellular arginine availability modulates eIF2\u03b1 O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis.", "journal": "Journal of biomedical science", "date": "2023-05-22", "authors": "Hung Yu-Wen, Ouyang Ching, Ping Xiaoli, Qi Yue, Wang Yi-Chang, Kung Hsing-Jien, Ann David K", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" } ], "reference": [ { "type": "PubMed", "id": "37217939", "url": "https://glygen.org/publication/PubMed/37217939" } ] }, { "title": "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells.", "journal": "Nature communications", "date": "2025-04-30", "authors": "Xu Senhan, Yin Kejun, Xu Xing, Fu Longping, Wu Ronghu", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" } ], "reference": [ { "type": "PubMed", "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" }, { "database": "O-GlcNAc Atlas", "id": "O95714", "url": "https://oglcnac.org/atlas/detail/O95714" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] } ], "crossref": [ { "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171", "database": "PubMed", "categories": [ "Other" ] }, { "id": "O95714", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714", "database": "O-GlcNAc Database", "categories": [ "Other" ] }, { "id": "37217939", "url": "https://glygen.org/publication/PubMed/37217939", "database": "PubMed", "categories": [ "Other" ] }, { "id": "40307207", "url": "https://glygen.org/publication/PubMed/40307207", "database": "PubMed", "categories": [ "Other" ] }, { "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928", "database": "PubMed", "categories": [ "Other" ] }, { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs147116947", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs147116947", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs147116947", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs147116947", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs147116947", "url": "https://www.ncbi.nlm.nih.gov/snp/rs147116947#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs147116947", "url": "http://gnomad.broadinstitute.org/awesome?query=rs147116947", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EANASTFHRSRTPLDKDLIN", "down_seq": "GICESSGKQCLPLVQLIQQL", "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_aa": "Thr", "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr995", "evidence": [ { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "O95714", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95714" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "40307207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40307207" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" } ] } ], "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" }, { "id": "rs147116947", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs147116947" }, { "id": "rs147116947", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs147116947" }, { "id": "rs147116947", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs147116947#frequency_tab" }, { "id": "rs147116947", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs147116947" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "1704", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "T", "sequence_mut": "M", "comment": "Somatic mutation passed 1 filters: o-glyco-site-loss (T->M).", "chr_id": "15", "chr_pos": "28254406", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "T995", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "glycosylation_flag", "snv_flag" ], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 11, "direction": "downstream", "id": "O95714-1.984.984", "categories": [ "snv_flag" ] } ], "glycosylation_flag": true, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_aa", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "O95714-1.2708.2708", "start_pos": 2708, "end_pos": 2708, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger.", "journal": "The Journal of cell biology", "date": "2012", "authors": "Danielsen JR, Povlsen LK, Villumsen BH, Streicher W, Nilsson J, Wikstrom M, Bekker-Jensen S, Mailand N", "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" }, { "database": "Reactome", "id": "R-HSA-3108214", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3108214" }, { "database": "iPTMnet", "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714" } ], "reference": [ { "type": "PubMed", "id": "22508508", "url": "https://glygen.org/publication/PubMed/22508508" } ] } ], "crossref": [ { "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "22508508", "url": "https://glygen.org/publication/PubMed/22508508", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "C", "start_aa": "C", "up_seq": "HWTGLLSEMELVPSIHPGVT", "down_seq": "DGCQMFPINGSRFKCRNCDD", "mutagenesis": [ { "sequence_org": "C", "sequence_mut": "S", "comment": "Abolishes binding to SUMO; when associated with S-2711.", "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" }, { "database": "PubMed", "id": "22508508", "url": "https://glygen.org/publication/PubMed/22508508" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 1, "direction": "downstream", "id": "O95714-1.2707.2707", "categories": [ "snv_flag" ] }, { "distance": 3, "direction": "upstream", "id": "O95714-1.2711.2711", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "O95714-1.2711.2711", "start_pos": 2711, "end_pos": 2711, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger.", "journal": "The Journal of cell biology", "date": "2012", "authors": "Danielsen JR, Povlsen LK, Villumsen BH, Streicher W, Nilsson J, Wikstrom M, Bekker-Jensen S, Mailand N", "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" }, { "database": "Reactome", "id": "R-HSA-3108214", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3108214" }, { "database": "iPTMnet", "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714" } ], "reference": [ { "type": "PubMed", "id": "22508508", "url": "https://glygen.org/publication/PubMed/22508508" } ] } ], "crossref": [ { "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "22508508", "url": "https://glygen.org/publication/PubMed/22508508", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "C", "start_aa": "C", "up_seq": "GLLSEMELVPSIHPGVTCDG", "down_seq": "QMFPINGSRFKCRNCDDFDF", "mutagenesis": [ { "sequence_org": "C", "sequence_mut": "S", "comment": "Abolishes binding to SUMO; when associated with S-2708.", "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" }, { "database": "PubMed", "id": "22508508", "url": "https://glygen.org/publication/PubMed/22508508" } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "mutagenesis_flag" ], "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "downstream", "id": "O95714-1.2707.2707", "categories": [ "snv_flag" ] }, { "distance": 3, "direction": "downstream", "id": "O95714-1.2708.2708", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "O95714-1.4827.4827", "start_pos": 4827, "end_pos": 4827, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes.", "journal": "Nature cell biology", "date": "2010", "authors": "Bekker-Jensen S, Rendtlew Danielsen J, Fugger K, Gromova I, Nerstedt A, Lukas C, Bartek J, Lukas J, Mailand N", "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" }, { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" }, { "database": "iPTMnet", "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714" } ], "reference": [ { "type": "PubMed", "id": "20023648", "url": "https://glygen.org/publication/PubMed/20023648" } ] }, { "title": "DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger.", "journal": "The Journal of cell biology", "date": "2012", "authors": "Danielsen JR, Povlsen LK, Villumsen BH, Streicher W, Nilsson J, Wikstrom M, Bekker-Jensen S, Mailand N", "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" }, { "database": "Reactome", "id": "R-HSA-3108214", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3108214" }, { "database": "iPTMnet", "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714" } ], "reference": [ { "type": "PubMed", "id": "22508508", "url": "https://glygen.org/publication/PubMed/22508508" } ] } ], "crossref": [ { "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "20023648", "url": "https://glygen.org/publication/PubMed/20023648", "database": "PubMed", "categories": [ "Other" ] }, { "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "22508508", "url": "https://glygen.org/publication/PubMed/22508508", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ADDSSDDSDNEDVDSFASDS", "down_seq": "QDYLTGH", "mutagenesis": [ { "sequence_org": "T", "sequence_mut": "A", "comment": "Prevents HERC2 C-terminal fragment binding to endogenous RNF8.", "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" }, { "database": "PubMed", "id": "20023648", "url": "https://glygen.org/publication/PubMed/20023648" } ] } ], "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" }, { "database": "PubMed", "id": "20023648", "url": "https://glygen.org/publication/PubMed/20023648" }, { "database": "iPTMnet", "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714" }, { "database": "PubMed", "id": "22508508", "url": "https://glygen.org/publication/PubMed/22508508" } ], "site_lbl": "Thr4827" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "mutagenesis_flag", "phosphorylation_flag" ], "glycosylation": [], "snv": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "O95714-1.4808.4808", "categories": [ "snv_flag" ] }, { "distance": 18, "direction": "downstream", "id": "O95714-1.4809.4809", "categories": [ "snv_flag" ] }, { "distance": 17, "direction": "downstream", "id": "O95714-1.4810.4810", "categories": [ "phosphorylation_flag" ] }, { "distance": 16, "direction": "downstream", "id": "O95714-1.4811.4811", "categories": [ "phosphorylation_flag" ] }, { "distance": 15, "direction": "downstream", "id": "O95714-1.4812.4812", "categories": [ "snv_flag" ] }, { "distance": 13, "direction": "downstream", "id": "O95714-1.4814.4814", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": false, "mutagenesis_flag": true, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "O95714-1.3543.3543", "start_pos": 3543, "end_pos": 3543, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "A", "start_aa": "A", "up_seq": "QNKAAGPEPQALDEFTSLLI", "down_seq": "DDTRVVVDLLKLSVCSRAGD", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "92", "subjects_positive": "1", "frequency": "1.1", "sequence_org": "A", "sequence_mut": "V", "comment": "Somatic mutation passed 2 filters: patient freq. (1.1%); num. of cancers (3).", "chr_id": "15", "chr_pos": "28163212", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "A3543", "keywords": [ "biomuta", "somatic", "cancer", "disease" ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 17, "direction": "downstream", "id": "O95714-1.3526.3526", "categories": [ "snv_flag" ] }, { "distance": 1, "direction": "upstream", "id": "O95714-1.3544.3544", "categories": [ "snv_flag" ] }, { "distance": 4, "direction": "upstream", "id": "O95714-1.3547.3547", "categories": [ "snv_flag" ] }, { "distance": 11, "direction": "upstream", "id": "O95714-1.3554.3554", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.4628.4628", "start_pos": 4628, "end_pos": 4628, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs200741102", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs200741102", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs200741102", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs200741102", "database": "1000Genomes", "categories": [ "Other" ] }, { "id": "rs200741102", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs200741102", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs200741102", "url": "http://gnomad.broadinstitute.org/awesome?query=rs200741102", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "A", "start_aa": "A", "up_seq": "ASGQDIQLSSKHTHITLDNR", "down_seq": "EYVRLAINYRLHEFDEQVAA", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" }, { "id": "rs200741102", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs200741102" }, { "id": "rs200741102", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs200741102" }, { "id": "rs200741102", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs200741102" }, { "id": "rs200741102", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs200741102" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "subjects_tested": "1704", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "A", "sequence_mut": "T", "comment": "Somatic mutation passed 2 filters: num. of cancers (3); n-glyco-sequon-gain (NRA->NRT).", "chr_id": "15", "chr_pos": "28114643", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "A4628", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1020.1020", "start_pos": 1020, "end_pos": 1020, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs778601927", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778601927", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs778601927", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778601927", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs778601927", "url": "https://www.ncbi.nlm.nih.gov/snp/rs778601927#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs778601927", "url": "http://gnomad.broadinstitute.org/awesome?query=rs778601927", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "A", "start_aa": "A", "up_seq": "SSGKQCLPLVQLIQQLLRNI", "down_seq": "SQTVARLKDVARRISSCLDF", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" }, { "id": "rs778601927", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778601927" }, { "id": "rs778601927", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778601927" }, { "id": "rs778601927", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs778601927#frequency_tab" }, { "id": "rs778601927", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs778601927" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "subjects_tested": "4799", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "A", "sequence_mut": "S", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (NIA->NIS).", "chr_id": "15", "chr_pos": "28248729", "ref_nt": "C", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "A1020", "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "unlinked_id_list": [ "DOID:4765" ], "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1056.1056", "start_pos": 1056, "end_pos": 1056, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "SCLDFEQHSRERSASLDLLL", "down_seq": "FQRLLISKLYPGESIGQTSD", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "720", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "R", "sequence_mut": "C", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28248621", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "R1056", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 3, "direction": "upstream", "id": "O95714-1.1059.1059", "categories": [ "snv_flag" ] }, { "distance": 20, "direction": "upstream", "id": "O95714-1.1076.1076", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1059.1059", "start_pos": 1059, "end_pos": 1059, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "DFEQHSRERSASLDLLLRFQ", "down_seq": "LLISKLYPGESIGQTSDISS", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "4484", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "H", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28248611", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "R1059", "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3675", "DOID:4455" ], "evidence": [ { "id": "263", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:263" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 3, "direction": "downstream", "id": "O95714-1.1056.1056", "categories": [ "snv_flag" ] }, { "distance": 17, "direction": "upstream", "id": "O95714-1.1076.1076", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1076.1076", "start_pos": 1076, "end_pos": 1076, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=", "database": "dbSNP", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "RFQRLLISKLYPGESIGQTS", "down_seq": "ISSPELMGVGSLLKKYTALL", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" }, { "id": "", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "subjects_tested": "2053", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (DIS->NIS).", "chr_id": "15", "chr_pos": "28248561", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "D1076", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 20, "direction": "downstream", "id": "O95714-1.1056.1056", "categories": [ "snv_flag" ] }, { "distance": 17, "direction": "downstream", "id": "O95714-1.1059.1059", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1150.1150", "start_pos": 1150, "end_pos": 1150, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1376931206", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1376931206", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1376931206", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1376931206#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs1376931206", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1376931206", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "G", "start_aa": "G", "up_seq": "TGVLLPELVVSIVLLLSKNA", "down_seq": "LMQEAGAVPLLGGLLEHLDR", "snv": [ { "evidence": [ { "id": "rs1376931206", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1376931206" }, { "id": "rs1376931206", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1376931206#frequency_tab" }, { "id": "rs1376931206", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1376931206" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "G", "sequence_mut": "S", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (NAG->NAS).", "chr_id": "15", "chr_pos": "28246010", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "G1150", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1198.1198", "start_pos": 1198, "end_pos": 1198, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "G", "start_aa": "G", "up_seq": "KERDDHEELAWPGIMESFFT", "down_seq": "QNCRNNEEVTLIRKADLENH", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "1773", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "G", "sequence_mut": "V", "comment": "Somatic mutation passed 1 filters: num. of cancers (5).", "chr_id": "15", "chr_pos": "28238757", "ref_nt": "C", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "G1198", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ], "unlinked_id_list": [ "DOID:4203", "DOID:3541", "DOID:4706", "DOID:1659", "DOID:368" ], "evidence": [ { "id": "1319", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1319" } ] }, { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3675", "DOID:4455" ], "evidence": [ { "id": "263", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:263" } ] }, { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematological tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "blood cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:0081452", "DOID:706", "DOID:1039", "DOID:5604", "DOID:6536", "DOID:0080638", "DOID:7757", "DOID:0050743", "DOID:4960", "DOID:8527", "DOID:1036", "DOID:5772" ], "evidence": [ { "id": "2531", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2531" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 13, "direction": "upstream", "id": "O95714-1.1211.1211", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.11.11", "start_pos": 11, "end_pos": 11, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "Q", "start_aa": "Q", "up_seq": "MPSESFCLAA", "down_seq": "ARLDSKWLKTDIQLAFTRDG", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "2617", "subjects_positive": "2", "frequency": "0.1", "sequence_org": "Q", "sequence_mut": "R", "comment": "Somatic mutation passed 1 filters: num. of cancers (4).", "chr_id": "15", "chr_pos": "28321402", "ref_nt": "T", "alt_nt": "C", "minor_allelic_frequency": "", "site_lbl": "Q11", "disease": [ { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ], "unlinked_id_list": [ "DOID:1795" ], "evidence": [ { "id": "1793", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1793" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] }, { "disease_id": "DOID:4362", "recommended_name": { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervical cancer", "description": "A female reproductive organ cancer that is located_in the cervix." }, "synonyms": [ { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervical neoplasm", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervix cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervix uteri cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "neoplasm of uterine cervix", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "tumor of the Cervix Uteri", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer", "description": "A primary or metastatic malignant neoplasm involving the cervix." }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cancer of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer, somatic", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervix cancer", "description": "" }, { "id": "MIM:603956", "resource": "MIM", "url": "https://www.omim.org/entry/603956", "name": "Cervical cancer", "description": "Cervical cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "4362", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4362" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1211.1211", "start_pos": 1211, "end_pos": 1211, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "IMESFFTGQNCRNNEEVTLI", "down_seq": "KADLENHNKDGGFWTVIDGK", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "2617", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "C", "comment": "Somatic mutation passed 1 filters: num. of cancers (4).", "chr_id": "15", "chr_pos": "28238719", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "R1211", "disease": [ { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ], "unlinked_id_list": [ "DOID:1795" ], "evidence": [ { "id": "1793", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1793" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematological tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "blood cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:0081452", "DOID:706", "DOID:1039", "DOID:5604", "DOID:6536", "DOID:0080638", "DOID:7757", "DOID:0050743", "DOID:4960", "DOID:8527", "DOID:1036", "DOID:5772" ], "evidence": [ { "id": "2531", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2531" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 13, "direction": "downstream", "id": "O95714-1.1198.1198", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1310.1310", "start_pos": 1310, "end_pos": 1310, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "G", "start_aa": "G", "up_seq": "VTIPDLGSLSSPLIDTERNL", "down_seq": "LLLGLHASYLAMSTPLSPVE", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "subjects_tested": "4799", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "G", "sequence_mut": "C", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (NLG->NLC).", "chr_id": "15", "chr_pos": "28237038", "ref_nt": "C", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "G1310", "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "unlinked_id_list": [ "DOID:4765" ], "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 8, "direction": "upstream", "id": "O95714-1.1318.1318", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1318.1318", "start_pos": 1318, "end_pos": 1318, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "LSSPLIDTERNLGLLLGLHA", "down_seq": "YLAMSTPLSPVEIECAKWLQ", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "4484", "subjects_positive": "2", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "L", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28237013", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "S1318", "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "unlinked_id_list": [ "DOID:4765" ], "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 8, "direction": "downstream", "id": "O95714-1.1310.1310", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1362.1362", "start_pos": 1362, "end_pos": 1362, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1228096748", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1228096748", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1228096748", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1228096748", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "FSGGLQTSQIHYSYNEEKDE", "down_seq": "HCSSPGGTPASKSRLCSHRR", "snv": [ { "evidence": [ { "id": "rs1228096748", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1228096748" }, { "id": "rs1228096748", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1228096748" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (DHC->NHC).", "chr_id": "15", "chr_pos": "28234204", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D1362", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 8, "direction": "upstream", "id": "O95714-1.1370.1370", "categories": [ "glycosylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1386.1386", "start_pos": 1386, "end_pos": 1386, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1902173739", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1902173739", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1902173739", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1902173739#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "SPGGTPASKSRLCSHRRALG", "down_seq": "HSQAFLQAIADNNIQDHNVK", "snv": [ { "evidence": [ { "id": "rs1902173739", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1902173739" }, { "id": "rs1902173739", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1902173739#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (DHS->NHS).", "chr_id": "15", "chr_pos": "28234132", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D1386", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 16, "direction": "downstream", "id": "O95714-1.1370.1370", "categories": [ "glycosylation_flag" ] }, { "distance": 14, "direction": "upstream", "id": "O95714-1.1400.1400", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1400.1400", "start_pos": 1400, "end_pos": 1400, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1902170036", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1902170036", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1902170036", "url": "https://www.ensembl.org/id/rs1902170036", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "I", "start_aa": "I", "up_seq": "HRRALGDHSQAFLQAIADNN", "down_seq": "QDHNVKDFLCQIERYCRQCH", "snv": [ { "evidence": [ { "id": "rs1902170036", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1902170036" }, { "id": "rs1902170036", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1902170036" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "I", "sequence_mut": "T", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (NNI->NNT).", "chr_id": "15", "chr_pos": "28234089", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I1400", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 14, "direction": "downstream", "id": "O95714-1.1386.1386", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1428.1428", "start_pos": 1428, "end_pos": 1428, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "P", "start_aa": "P", "up_seq": "FLCQIERYCRQCHLTTPIMF", "down_seq": "PEHPVEEVGRLLLCCLLKHE", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "3601", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "P", "sequence_mut": "S", "comment": "Somatic mutation passed 1 filters: num. of cancers (4).", "chr_id": "15", "chr_pos": "28233733", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "P1428", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3675", "DOID:4455" ], "evidence": [ { "id": "263", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:263" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1479.1479", "start_pos": 1479, "end_pos": 1479, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1902095127", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1902095127", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1902095127", "url": "https://www.ensembl.org/id/rs1902095127", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "HAGALGIEQVKHRTLPKSVV", "down_seq": "VCRVVYQAKCSLIKTHQEQG", "snv": [ { "evidence": [ { "id": "rs1902095127", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1902095127" }, { "id": "rs1902095127", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1902095127" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (DVC->NVC).", "chr_id": "15", "chr_pos": "28233478", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D1479", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1542.1542", "start_pos": 1542, "end_pos": 1542, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "PAVCNDLSIMSKFKLLSSLP", "down_seq": "WRRIAQKIIRERRKKRVPKK", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "720", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "R", "sequence_mut": "H", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28233196", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "R1542", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 10, "direction": "upstream", "id": "O95714-1.1552.1552", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1552.1552", "start_pos": 1552, "end_pos": 1552, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "SKFKLLSSLPRWRRIAQKII", "down_seq": "ERRKKRVPKKPESTDDEEKI", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "3601", "subjects_positive": "2", "frequency": "0.1", "sequence_org": "R", "sequence_mut": "*", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28233167", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "R1552", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] }, { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematological tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "blood cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:0081452", "DOID:706", "DOID:1039", "DOID:5604", "DOID:6536", "DOID:0080638", "DOID:7757", "DOID:0050743", "DOID:4960", "DOID:8527", "DOID:1036", "DOID:5772" ], "evidence": [ { "id": "2531", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2531" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 10, "direction": "downstream", "id": "O95714-1.1542.1542", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1656.1656", "start_pos": 1656, "end_pos": 1656, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "LSTIAEFALKEEPVDVEKMR", "down_seq": "CLLKQLERAEVRLEGIDTIL", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "2617", "subjects_positive": "2", "frequency": "0.1", "sequence_org": "K", "sequence_mut": "*", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28229691", "ref_nt": "T", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "K1656", "disease": [ { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ], "unlinked_id_list": [ "DOID:1795" ], "evidence": [ { "id": "1793", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1793" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 12, "direction": "upstream", "id": "O95714-1.1668.1668", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1668.1668", "start_pos": 1668, "end_pos": 1668, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "PVDVEKMRKCLLKQLERAEV", "down_seq": "LEGIDTILKLASKNFLLPSV", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "2053", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "C", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28229578", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "R1668", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 12, "direction": "downstream", "id": "O95714-1.1656.1656", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1725.1725", "start_pos": 1725, "end_pos": 1725, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "DIGEPLTDCLKDVDLIPPFN", "down_seq": "MLLEVTFGKLYAWAVQNIRN", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "589", "subjects_positive": "1", "frequency": "0.2", "sequence_org": "R", "sequence_mut": "W", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28229294", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "R1725", "disease": [ { "disease_id": "DOID:2394", "recommended_name": { "id": "DOID:2394", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary." }, "synonyms": [ { "id": "DOID:2394", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2394", "name": "malignant Ovarian tumor", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2394", "name": "malignant tumour of ovary", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2394", "name": "ovarian neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2394", "name": "ovary neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2394", "name": "primary ovarian cancer", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2394", "name": "tumor of the Ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas." }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumour of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumour", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, somatic", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumour", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary cancer", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "OVCAS1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MIM:167000", "resource": "MIM", "url": "https://www.omim.org/entry/167000", "name": "Ovarian cancer", "description": "Ovarian cancer" } ], "unlinked_id_list": [ "DOID:2151" ], "evidence": [ { "id": "2394", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2394" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ], "unlinked_id_list": [ "DOID:1795" ], "evidence": [ { "id": "1793", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1793" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "upstream", "id": "O95714-1.1744.1744", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1744.1744", "start_pos": 1744, "end_pos": 1744, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "NRMLLEVTFGKLYAWAVQNI", "down_seq": "NVLMDASAKFKELGIQPVPL", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "1704", "subjects_positive": "3", "frequency": "0.2", "sequence_org": "R", "sequence_mut": "Q", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28229236", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "R1744", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ], "unlinked_id_list": [ "DOID:4203", "DOID:3541", "DOID:4706", "DOID:1659", "DOID:368" ], "evidence": [ { "id": "1319", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1319" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "unlinked_id_list": [ "DOID:4765" ], "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "O95714-1.1725.1725", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1771.1771", "start_pos": 1771, "end_pos": 1771, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1596284273", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1596284273", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1596284273", "url": "https://www.ensembl.org/id/rs1596284273", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "SAKFKELGIQPVPLQTITNE", "down_seq": "PSGPSLGTIPQARFLLVMLS", "snv": [ { "evidence": [ { "id": "rs1596284273", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1596284273" }, { "id": "rs1596284273", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1596284273" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "N", "sequence_mut": "T", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (NEN->NET).", "chr_id": "15", "chr_pos": "28228370", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N1771", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 1, "direction": "upstream", "id": "O95714-1.1772.1772", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1772.1772", "start_pos": 1772, "end_pos": 1772, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs756054844", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs756054844", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs756054844", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs756054844", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs756054844", "url": "https://www.ncbi.nlm.nih.gov/snp/rs756054844#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs756054844", "url": "http://gnomad.broadinstitute.org/awesome?query=rs756054844", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "rs148787940", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148787940", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs148787940", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs148787940", "database": "1000Genomes", "categories": [ "Other" ] }, { "id": "rs148787940", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148787940", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs148787940", "url": "https://www.ncbi.nlm.nih.gov/snp/rs148787940#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs148787940", "url": "http://gnomad.broadinstitute.org/awesome?query=rs148787940", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "P", "start_aa": "P", "up_seq": "AKFKELGIQPVPLQTITNEN", "down_seq": "SGPSLGTIPQARFLLVMLSM", "snv": [ { "evidence": [ { "id": "rs756054844", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs756054844" }, { "id": "rs756054844", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs756054844" }, { "id": "rs756054844", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs756054844#frequency_tab" }, { "id": "rs756054844", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs756054844" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "P", "sequence_mut": "L", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (NPS->NLS).", "chr_id": "15", "chr_pos": "28228367", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P1772", "disease": [ { "disease_id": "DOID:0081203", "recommended_name": { "id": "DOID:0081203", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0081203", "name": "autosomal recessive intellectual developmental disorder 38", "description": "An autosomal recessive intellectual developmental disorder that has_material_basis_in homozygous mutation in the HERC2 gene on chromosome 15q13." }, "synonyms": [ { "id": "MONDO:0014224", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014224", "name": "developmental delay with autism spectrum disorder and gait instability", "description": "Developmental delay with autism spectrum disorder and gait instability is a rare, genetic, neurological disorder characterized by infant hypotonia and feeding difficulties, global development delay, mild to moderated intellectual disability, delayed independent ambulation, broad-based gait with arms upheld and flexed at the elbow with brisk walking or running, and limited language skills. Behavior patterns are highly variable and range from sociable and affectionate to autistic behavior." }, { "id": "MONDO:0014224", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014224", "name": "developmental delay with ASD and gait instability", "description": "" }, { "id": "MONDO:0014224", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014224", "name": "intellectual developmental disorder, autosomal recessive 38", "description": "" }, { "id": "MONDO:0014224", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014224", "name": "intellectual disability, autosomal recessive type 38", "description": "" }, { "id": "MONDO:0014224", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014224", "name": "mental retardation, autosomal recessive type 38", "description": "" }, { "id": "MONDO:0014224", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014224", "name": "MRT38", "description": "" }, { "id": "MONDO:0014224", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014224", "name": "intellectual disability, autosomal recessive 38", "description": "" }, { "id": "MONDO:0014224", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014224", "name": "mental retardation, autosomal recessive 38", "description": "" }, { "id": "MIM:615516", "resource": "MIM", "url": "https://www.omim.org/entry/615516", "name": "Intellectual developmental disorder, autosomal recessive 38", "description": "Intellectual developmental disorder, autosomal recessive 38" } ], "unlinked_id_list": [], "evidence": [ { "id": "615516", "database": "MIM", "url": "https://www.omim.org/entry/615516" }, { "id": "0081203", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0081203" } ] } ], "keywords": [ "ebi", "germline", "disease" ] }, { "evidence": [ { "id": "rs148787940", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148787940" }, { "id": "rs148787940", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs148787940" }, { "id": "rs148787940", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148787940" }, { "id": "rs148787940", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs148787940#frequency_tab" }, { "id": "rs148787940", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs148787940" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "P", "sequence_mut": "S", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (NPS->NSS).", "chr_id": "15", "chr_pos": "28228368", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "0.000196232", "site_lbl": "P1772", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 1, "direction": "downstream", "id": "O95714-1.1771.1771", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.179.179", "start_pos": 179, "end_pos": 179, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs148005149", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148005149", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs148005149", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs148005149", "database": "1000Genomes", "categories": [ "Other" ] }, { "id": "rs148005149", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148005149", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs148005149", "url": "https://www.ncbi.nlm.nih.gov/snp/rs148005149#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs148005149", "url": "http://gnomad.broadinstitute.org/awesome?query=rs148005149", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "FQENVKVKWKSSGISLPPVD", "down_seq": "KSSRPAGKGVEGLARVGSRA", "snv": [ { "evidence": [ { "id": "rs148005149", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148005149" }, { "id": "rs148005149", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs148005149" }, { "id": "rs148005149", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148005149" }, { "id": "rs148005149", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs148005149#frequency_tab" }, { "id": "rs148005149", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs148005149" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (KKS->NKS).", "chr_id": "15", "chr_pos": "28280073", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "0.000196232", "site_lbl": "K179", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1809.1809", "start_pos": 1809, "end_pos": 1809, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1191505026", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1191505026", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1191505026", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1191505026#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs1191505026", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1191505026", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "G", "start_aa": "G", "up_seq": "MLSMLTLQHGANNLDLLLNS", "down_seq": "MLALTQTALRLIGPSCDNVE", "snv": [ { "evidence": [ { "id": "rs1191505026", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1191505026" }, { "id": "rs1191505026", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1191505026#frequency_tab" }, { "id": "rs1191505026", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1191505026" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "G", "sequence_mut": "S", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (NSG->NSS).", "chr_id": "15", "chr_pos": "28228257", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "G1809", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1942.1942", "start_pos": 1942, "end_pos": 1942, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.", "journal": "Cell", "date": "2006", "authors": "Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M", "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" }, { "database": "iPTMnet", "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714" } ], "reference": [ { "type": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" }, { "database": "iPTMnet", "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.", "journal": "Analytical chemistry", "date": "2009", "authors": "Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S", "evidence": [ { "database": "iPTMnet", "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714" } ], "reference": [ { "type": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] } ], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983", "database": "PubMed", "categories": [ "Other" ] }, { "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "GKYDLKLAELPAAAQPSAED", "down_seq": "DTEDDSEAEQTERNIHPTAM", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "720", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "S", "sequence_mut": "L", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28220472", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "S1942", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:4362", "recommended_name": { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervical cancer", "description": "A female reproductive organ cancer that is located_in the cervix." }, "synonyms": [ { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervical neoplasm", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervix cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervix uteri cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "neoplasm of uterine cervix", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "tumor of the Cervix Uteri", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer", "description": "A primary or metastatic malignant neoplasm involving the cervix." }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cancer of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer, somatic", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervix cancer", "description": "" }, { "id": "MIM:603956", "resource": "MIM", "url": "https://www.omim.org/entry/603956", "name": "Cervical cancer", "description": "Cervical cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "4362", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4362" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" }, { "database": "iPTMnet", "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ], "site_lbl": "Ser1942" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag", "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "downstream", "id": "O95714-1.1938.1938", "categories": [ "phosphorylation_flag" ] }, { "distance": 2, "direction": "upstream", "id": "O95714-1.1944.1944", "categories": [ "phosphorylation_flag" ] }, { "distance": 6, "direction": "upstream", "id": "O95714-1.1948.1948", "categories": [ "phosphorylation_flag" ] }, { "distance": 9, "direction": "upstream", "id": "O95714-1.1951.1951", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "O95714-1.1951.1951", "start_pos": 1951, "end_pos": 1951, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "E", "start_aa": "E", "up_seq": "LPAAAQPSAEDSDTEDDSEA", "down_seq": "QTERNIHPTAMMFTSTINLL", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "1773", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "E", "sequence_mut": "K", "comment": "Somatic mutation passed 1 filters: num. of cancers (4).", "chr_id": "15", "chr_pos": "28218666", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "E1951", "disease": [ { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 13, "direction": "downstream", "id": "O95714-1.1938.1938", "categories": [ "phosphorylation_flag" ] }, { "distance": 9, "direction": "downstream", "id": "O95714-1.1942.1942", "categories": [ "snv_flag", "phosphorylation_flag" ] }, { "distance": 7, "direction": "downstream", "id": "O95714-1.1944.1944", "categories": [ "phosphorylation_flag" ] }, { "distance": 3, "direction": "downstream", "id": "O95714-1.1948.1948", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.1990.1990", "start_pos": 1990, "end_pos": 1990, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1900176155", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1900176155", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1900176155", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1900176155#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LLQTLCLSAGVHAEIMQSEA", "down_seq": "KTLCGLLRMLVESGTTDKTS", "snv": [ { "evidence": [ { "id": "rs1900176155", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1900176155" }, { "id": "rs1900176155", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1900176155#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (TKT->NKT).", "chr_id": "15", "chr_pos": "28218548", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T1990", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 13, "direction": "upstream", "id": "O95714-1.2003.2003", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2003.2003", "start_pos": 2003, "end_pos": 2003, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "EIMQSEATKTLCGLLRMLVE", "down_seq": "GTTDKTSSPNRLVYREQHRS", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "subjects_tested": "2053", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "N", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (SGT->NGT).", "chr_id": "15", "chr_pos": "28218509", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "S2003", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 13, "direction": "downstream", "id": "O95714-1.1990.1990", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2031.2031", "start_pos": 2031, "end_pos": 2031, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "SPNRLVYREQHRSWCTLGFV", "down_seq": "SIALTPQVCGALSSPQWITL", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "4484", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "Q", "comment": "Somatic mutation passed 1 filters: num. of cancers (4).", "chr_id": "15", "chr_pos": "28215739", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "R2031", "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematological tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "blood cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:0081452", "DOID:706", "DOID:1039", "DOID:5604", "DOID:6536", "DOID:0080638", "DOID:7757", "DOID:0050743", "DOID:4960", "DOID:8527", "DOID:1036", "DOID:5772" ], "evidence": [ { "id": "2531", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2531" } ] }, { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ], "unlinked_id_list": [ "DOID:1795" ], "evidence": [ { "id": "1793", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1793" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 15, "direction": "upstream", "id": "O95714-1.2046.2046", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2046.2046", "start_pos": 2046, "end_pos": 2046, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "P", "start_aa": "P", "up_seq": "TLGFVRSIALTPQVCGALSS", "down_seq": "QWITLLMKVVEGHAPFTATS", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "720", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "P", "sequence_mut": "L", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28215694", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "P2046", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 15, "direction": "downstream", "id": "O95714-1.2031.2031", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2085.2085", "start_pos": 2085, "end_pos": 2085, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "TSLQRQILAVHLLQAVLPSW", "down_seq": "KTERARDMKCLVEKLFDFLG", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "subjects_tested": "1704", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (DKT->NKT).", "chr_id": "15", "chr_pos": "28214760", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "D2085", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2143.2143", "start_pos": 2143, "end_pos": 2143, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "A", "start_aa": "A", "up_seq": "LRRRRVRPQASLTATHSSTL", "down_seq": "EEVVALLRTLHSLTQWNGLI", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "1773", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "A", "sequence_mut": "V", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28214203", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "A2143", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 8, "direction": "upstream", "id": "O95714-1.2151.2151", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2151.2151", "start_pos": 2151, "end_pos": 2151, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "QASLTATHSSTLAEEVVALL", "down_seq": "TLHSLTQWNGLINKYINSQL", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "9251", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "H", "comment": "Somatic mutation passed 1 filters: num. of cancers (4).", "chr_id": "15", "chr_pos": "28214179", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "R2151", "disease": [ { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematological tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "blood cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:0081452", "DOID:706", "DOID:1039", "DOID:5604", "DOID:6536", "DOID:0080638", "DOID:7757", "DOID:0050743", "DOID:4960", "DOID:8527", "DOID:1036", "DOID:5772" ], "evidence": [ { "id": "2531", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2531" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 8, "direction": "downstream", "id": "O95714-1.2143.2143", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2184.2184", "start_pos": 2184, "end_pos": 2184, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "E", "start_aa": "E", "up_seq": "NKYINSQLRSITHSFVGRPS", "down_seq": "GAQLEDYFPDSENPEVGGLM", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "9251", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "E", "sequence_mut": "K", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28214081", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "E2184", "disease": [ { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematological tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "blood cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:0081452", "DOID:706", "DOID:1039", "DOID:5604", "DOID:6536", "DOID:0080638", "DOID:7757", "DOID:0050743", "DOID:4960", "DOID:8527", "DOID:1036", "DOID:5772" ], "evidence": [ { "id": "2531", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2531" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 1, "direction": "upstream", "id": "O95714-1.2185.2185", "categories": [ "snv_flag" ] }, { "distance": 5, "direction": "upstream", "id": "O95714-1.2189.2189", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2185.2185", "start_pos": 2185, "end_pos": 2185, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "G", "start_aa": "G", "up_seq": "KYINSQLRSITHSFVGRPSE", "down_seq": "AQLEDYFPDSENPEVGGLMA", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "1773", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "G", "sequence_mut": "W", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28214078", "ref_nt": "C", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "G2185", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "unlinked_id_list": [ "DOID:4765" ], "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 1, "direction": "downstream", "id": "O95714-1.2184.2184", "categories": [ "snv_flag" ] }, { "distance": 4, "direction": "upstream", "id": "O95714-1.2189.2189", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2189.2189", "start_pos": 2189, "end_pos": 2189, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "E", "start_aa": "E", "up_seq": "SQLRSITHSFVGRPSEGAQL", "down_seq": "DYFPDSENPEVGGLMAVLAV", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "720", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "E", "sequence_mut": "K", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28213963", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "E2189", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ], "unlinked_id_list": [ "DOID:1542" ], "evidence": [ { "id": "11934", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11934" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 5, "direction": "downstream", "id": "O95714-1.2184.2184", "categories": [ "snv_flag" ] }, { "distance": 4, "direction": "downstream", "id": "O95714-1.2185.2185", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.219.219", "start_pos": 219, "end_pos": 219, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs150593330", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs150593330", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs150593330", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs150593330", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs150593330", "url": "https://www.ncbi.nlm.nih.gov/snp/rs150593330#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs150593330", "url": "http://gnomad.broadinstitute.org/awesome?query=rs150593330", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "AALSFAFAFLRRAWRSGEDA", "down_seq": "LCSELLQESLDALRALPEAS", "snv": [ { "evidence": [ { "id": "rs150593330", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs150593330" }, { "id": "rs150593330", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs150593330" }, { "id": "rs150593330", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs150593330#frequency_tab" }, { "id": "rs150593330", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs150593330" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (DLC->NLC).", "chr_id": "15", "chr_pos": "28274436", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D219", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2232.2232", "start_pos": 2232, "end_pos": 2232, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "GIDGRLRLGGQVMHDEFGEG", "down_seq": "VTRITPKGKITVQFSDMRTC", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "subjects_tested": "1704", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "T", "sequence_mut": "N", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (TVT->NVT).", "chr_id": "15", "chr_pos": "28213833", "ref_nt": "G", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "T2232", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2274.2274", "start_pos": 2274, "end_pos": 2274, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1207256292", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1207256292", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1207256292", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1207256292", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "P", "start_aa": "P", "up_seq": "VCPLNQLKPLPAVAFNVNNL", "down_seq": "FTEPMLSVWAQLVNLAGSKL", "snv": [ { "evidence": [ { "id": "rs1207256292", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1207256292" }, { "id": "rs1207256292", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1207256292" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "P", "sequence_mut": "S", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (NLP->NLS).", "chr_id": "15", "chr_pos": "28212550", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P2274", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 16, "direction": "upstream", "id": "O95714-1.2290.2290", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2290.2290", "start_pos": 2290, "end_pos": 2290, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs978465712", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs978465712", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs978465712", "url": "https://www.ncbi.nlm.nih.gov/snp/rs978465712#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs978465712", "url": "http://gnomad.broadinstitute.org/awesome?query=rs978465712", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "A", "start_aa": "A", "up_seq": "VNNLPFTEPMLSVWAQLVNL", "down_seq": "GSKLEKHKIKKSTKQAFAGQ", "snv": [ { "evidence": [ { "id": "rs978465712", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs978465712" }, { "id": "rs978465712", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs978465712#frequency_tab" }, { "id": "rs978465712", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs978465712" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "A", "sequence_mut": "S", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (NLA->NLS).", "chr_id": "15", "chr_pos": "28212502", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A2290", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs978465712", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs978465712" }, { "id": "rs978465712", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs978465712#frequency_tab" }, { "id": "rs978465712", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs978465712" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "A", "sequence_mut": "T", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (NLA->NLT).", "chr_id": "15", "chr_pos": "28212502", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A2290", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 16, "direction": "downstream", "id": "O95714-1.2274.2274", "categories": [ "snv_flag" ] }, { "distance": 10, "direction": "upstream", "id": "O95714-1.2300.2300", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2300.2300", "start_pos": 2300, "end_pos": 2300, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs779041581", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs779041581", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs779041581", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs779041581", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs779041581", "url": "https://www.ncbi.nlm.nih.gov/snp/rs779041581#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs779041581", "url": "http://gnomad.broadinstitute.org/awesome?query=rs779041581", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "LSVWAQLVNLAGSKLEKHKI", "down_seq": "KSTKQAFAGQVDLDLLRCQQ", "snv": [ { "evidence": [ { "id": "rs779041581", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs779041581" }, { "id": "rs779041581", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs779041581" }, { "id": "rs779041581", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs779041581#frequency_tab" }, { "id": "rs779041581", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs779041581" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (KKS->NKS).", "chr_id": "15", "chr_pos": "28212470", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K2300", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 10, "direction": "downstream", "id": "O95714-1.2290.2290", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2333.2333", "start_pos": 2333, "end_pos": 2333, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "L", "start_aa": "L", "up_seq": "LDLLRCQQLKLYILKAGRAL", "down_seq": "SHQDKLRQILSQPAVQETGT", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "4177", "subjects_positive": "3", "frequency": "0.1", "sequence_org": "L", "sequence_mut": "F", "comment": "Somatic mutation passed 1 filters: num. of cancers (4).", "chr_id": "15", "chr_pos": "28211074", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "L2333", "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "unlinked_id_list": [ "DOID:4765" ], "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematological tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "blood cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:0081452", "DOID:706", "DOID:1039", "DOID:5604", "DOID:6536", "DOID:0080638", "DOID:7757", "DOID:0050743", "DOID:4960", "DOID:8527", "DOID:1036", "DOID:5772" ], "evidence": [ { "id": "2531", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2531" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 20, "direction": "upstream", "id": "O95714-1.2353.2353", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2353.2353", "start_pos": 2353, "end_pos": 2353, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "LSHQDKLRQILSQPAVQETG", "down_seq": "VHTDDGAVVSPDLGDMSPEG", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "4799", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "T", "sequence_mut": "S", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28211013", "ref_nt": "G", "alt_nt": "C", "minor_allelic_frequency": "", "site_lbl": "T2353", "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "unlinked_id_list": [ "DOID:4765" ], "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 20, "direction": "downstream", "id": "O95714-1.2333.2333", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.242.242", "start_pos": 242, "end_pos": 242, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs769326690", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs769326690", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs769326690", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs769326690", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs769326690", "url": "http://gnomad.broadinstitute.org/awesome?query=rs769326690", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "SELLQESLDALRALPEASLF", "down_seq": "ESTVSSVWLEVVERATRFLR", "snv": [ { "evidence": [ { "id": "rs769326690", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs769326690" }, { "id": "rs769326690", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs769326690" }, { "id": "rs769326690", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs769326690" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (DES->NES).", "chr_id": "15", "chr_pos": "28274367", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D242", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2504.2504", "start_pos": 2504, "end_pos": 2504, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "GASGNASSLPGVEALVGWLL", "down_seq": "HSDIQVTELSDADTVSDEYS", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "subjects_tested": "2670", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (DHS->NHS).", "chr_id": "15", "chr_pos": "28202220", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "D2504", "disease": [ { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ], "unlinked_id_list": [ "DOID:4203", "DOID:3541", "DOID:4706", "DOID:1659", "DOID:368" ], "evidence": [ { "id": "1319", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1319" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2546.2546", "start_pos": 2546, "end_pos": 2546, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "EEVVEDVDDAAYSMSTGAVV", "down_seq": "ESQTYKKRADFLSNDDYAVY", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "1773", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "T", "sequence_mut": "M", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28201535", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "T2546", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2630.2630", "start_pos": 2630, "end_pos": 2630, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "Y", "start_aa": "Y", "up_seq": "DWQQKGGTYWVRYIHVELIG", "down_seq": "PPPSSSSHIKIGDKVRVKAS", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "92", "subjects_positive": "1", "frequency": "1.1", "sequence_org": "Y", "sequence_mut": "H", "comment": "Somatic mutation passed 1 filters: patient freq. (1.1%).", "chr_id": "15", "chr_pos": "28198501", "ref_nt": "A", "alt_nt": "G", "minor_allelic_frequency": "", "site_lbl": "Y2630", "keywords": [ "biomuta", "somatic", "cancer" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2674.2674", "start_pos": 2674, "end_pos": 2674, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "A", "start_aa": "A", "up_seq": "PKYKWGSVTHQSVGVVKAFS", "down_seq": "NGKDIIVDFPQQSHWTGLLS", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "92", "subjects_positive": "1", "frequency": "1.1", "sequence_org": "A", "sequence_mut": "S", "comment": "Somatic mutation passed 1 filters: patient freq. (1.1%).", "chr_id": "15", "chr_pos": "28196561", "ref_nt": "C", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "A2674", "keywords": [ "biomuta", "somatic", "cancer" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2707.2707", "start_pos": 2707, "end_pos": 2707, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "SHWTGLLSEMELVPSIHPGV", "down_seq": "CDGCQMFPINGSRFKCRNCD", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "4177", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "T", "sequence_mut": "M", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28196461", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "T2707", "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] }, { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ], "unlinked_id_list": [ "DOID:4203", "DOID:3541", "DOID:4706", "DOID:1659", "DOID:368" ], "evidence": [ { "id": "1319", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1319" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 1, "direction": "upstream", "id": "O95714-1.2708.2708", "categories": [ "mutagenesis_flag" ] }, { "distance": 4, "direction": "upstream", "id": "O95714-1.2711.2711", "categories": [ "mutagenesis_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.274.274", "start_pos": 274, "end_pos": 274, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "A", "start_aa": "A", "up_seq": "VERATRFLRSVVTGDVHGTP", "down_seq": "TKGPGSIPLQDQHLALAILL", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "9251", "subjects_positive": "42", "frequency": "0.5", "sequence_org": "A", "sequence_mut": "G", "comment": "Somatic mutation passed 1 filters: patient count (42/9251).", "chr_id": "15", "chr_pos": "28272984", "ref_nt": "G", "alt_nt": "C", "minor_allelic_frequency": "", "site_lbl": "A274", "disease": [ { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematological tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "blood cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:0081452", "DOID:706", "DOID:1039", "DOID:5604", "DOID:6536", "DOID:0080638", "DOID:7757", "DOID:0050743", "DOID:4960", "DOID:8527", "DOID:1036", "DOID:5772" ], "evidence": [ { "id": "2531", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2531" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "downstream", "id": "O95714-1.272.272", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2757.2757", "start_pos": 2757, "end_pos": 2757, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "A", "start_aa": "A", "up_seq": "KTKKHNTRHTFGRINEPGQS", "down_seq": "VFCGRSGKQLKRCHSSQPGM", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "720", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "A", "sequence_mut": "V", "comment": "Somatic mutation passed 1 filters: num. of cancers (4).", "chr_id": "15", "chr_pos": "28192142", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "A2757", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 5, "direction": "upstream", "id": "O95714-1.2762.2762", "categories": [ "snv_flag" ] }, { "distance": 11, "direction": "upstream", "id": "O95714-1.2768.2768", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2762.2762", "start_pos": 2762, "end_pos": 2762, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "NTRHTFGRINEPGQSAVFCG", "down_seq": "SGKQLKRCHSSQPGMLLDSW", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "1557", "subjects_positive": "2", "frequency": "0.1", "sequence_org": "R", "sequence_mut": "G", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28192128", "ref_nt": "G", "alt_nt": "C", "minor_allelic_frequency": "", "site_lbl": "R2762", "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3675", "DOID:4455" ], "evidence": [ { "id": "263", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:263" } ] }, { "disease_id": "DOID:2394", "recommended_name": { "id": "DOID:2394", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary." }, "synonyms": [ { "id": "DOID:2394", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2394", "name": "malignant Ovarian tumor", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2394", "name": "malignant tumour of ovary", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2394", "name": "ovarian neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2394", "name": "ovary neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2394", "name": "primary ovarian cancer", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2394", "name": "tumor of the Ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas." }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumour of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumour", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, somatic", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumour", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary cancer", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "OVCAS1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MIM:167000", "resource": "MIM", "url": "https://www.omim.org/entry/167000", "name": "Ovarian cancer", "description": "Ovarian cancer" } ], "unlinked_id_list": [ "DOID:2151" ], "evidence": [ { "id": "2394", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2394" } ] }, { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ], "unlinked_id_list": [ "DOID:4203", "DOID:3541", "DOID:4706", "DOID:1659", "DOID:368" ], "evidence": [ { "id": "1319", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1319" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 5, "direction": "downstream", "id": "O95714-1.2757.2757", "categories": [ "snv_flag" ] }, { "distance": 6, "direction": "upstream", "id": "O95714-1.2768.2768", "categories": [ "snv_flag" ] }, { "distance": 19, "direction": "upstream", "id": "O95714-1.2781.2781", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2768.2768", "start_pos": 2768, "end_pos": 2768, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1411819357", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1411819357", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1411819357", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1411819357#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "GRINEPGQSAVFCGRSGKQL", "down_seq": "RCHSSQPGMLLDSWSRMVKS", "snv": [ { "evidence": [ { "id": "rs1411819357", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1411819357" }, { "id": "rs1411819357", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1411819357#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (KRC->NRC).", "chr_id": "15", "chr_pos": "28192108", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K2768", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 11, "direction": "downstream", "id": "O95714-1.2757.2757", "categories": [ "snv_flag" ] }, { "distance": 6, "direction": "downstream", "id": "O95714-1.2762.2762", "categories": [ "snv_flag" ] }, { "distance": 13, "direction": "upstream", "id": "O95714-1.2781.2781", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2781.2781", "start_pos": 2781, "end_pos": 2781, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs146558015", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs146558015", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs146558015", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs146558015", "database": "1000Genomes", "categories": [ "Other" ] }, { "id": "rs146558015", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs146558015", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs146558015", "url": "https://www.ncbi.nlm.nih.gov/snp/rs146558015#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs146558015", "url": "http://gnomad.broadinstitute.org/awesome?query=rs146558015", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "GRSGKQLKRCHSSQPGMLLD", "down_seq": "WSRMVKSLNVSSSVNQASRL", "snv": [ { "evidence": [ { "id": "rs146558015", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs146558015" }, { "id": "rs146558015", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs146558015" }, { "id": "rs146558015", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs146558015" }, { "id": "rs146558015", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs146558015#frequency_tab" }, { "id": "rs146558015", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs146558015" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (SWS->NWS).", "chr_id": "15", "chr_pos": "28192070", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "0.000392465", "site_lbl": "S2781", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "O95714-1.2762.2762", "categories": [ "snv_flag" ] }, { "distance": 13, "direction": "downstream", "id": "O95714-1.2768.2768", "categories": [ "snv_flag" ] }, { "distance": 9, "direction": "upstream", "id": "O95714-1.2790.2790", "categories": [ "glycosylation_flag" ] }, { "distance": 11, "direction": "upstream", "id": "O95714-1.2792.2792", "categories": [ "snv_flag" ] }, { "distance": 17, "direction": "upstream", "id": "O95714-1.2798.2798", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2792.2792", "start_pos": 2792, "end_pos": 2792, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "SSQPGMLLDSWSRMVKSLNV", "down_seq": "SSVNQASRLIDGSEPCWQSS", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "subjects_tested": "1906", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "S", "sequence_mut": "L", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-loss (NVS->NVL).", "chr_id": "15", "chr_pos": "28192037", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "S2792", "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "11054", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 11, "direction": "downstream", "id": "O95714-1.2781.2781", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "downstream", "id": "O95714-1.2790.2790", "categories": [ "glycosylation_flag" ] }, { "distance": 6, "direction": "upstream", "id": "O95714-1.2798.2798", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2798.2798", "start_pos": 2798, "end_pos": 2798, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "A", "start_aa": "A", "up_seq": "LLDSWSRMVKSLNVSSSVNQ", "down_seq": "SRLIDGSEPCWQSSGSQGKH", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "subjects_tested": "9251", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "A", "sequence_mut": "T", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (NQA->NQT).", "chr_id": "15", "chr_pos": "28192020", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "A2798", "disease": [ { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematological tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "blood cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:0081452", "DOID:706", "DOID:1039", "DOID:5604", "DOID:6536", "DOID:0080638", "DOID:7757", "DOID:0050743", "DOID:4960", "DOID:8527", "DOID:1036", "DOID:5772" ], "evidence": [ { "id": "2531", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2531" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 17, "direction": "downstream", "id": "O95714-1.2781.2781", "categories": [ "snv_flag" ] }, { "distance": 8, "direction": "downstream", "id": "O95714-1.2790.2790", "categories": [ "glycosylation_flag" ] }, { "distance": 6, "direction": "downstream", "id": "O95714-1.2792.2792", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2841.2841", "start_pos": 2841, "end_pos": 2841, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1353995088", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1353995088", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1353995088", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1353995088", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "RLEIFPDVLVHRLKMIVDPA", "down_seq": "SSYMPSLVVVSGGNSLNNLI", "snv": [ { "evidence": [ { "id": "rs1353995088", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1353995088" }, { "id": "rs1353995088", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1353995088" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (DSS->NSS).", "chr_id": "15", "chr_pos": "28191175", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D2841", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 20, "direction": "upstream", "id": "O95714-1.2861.2861", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2861.2861", "start_pos": 2861, "end_pos": 2861, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs767335178", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs767335178", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs767335178", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs767335178", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs767335178", "url": "https://www.ncbi.nlm.nih.gov/snp/rs767335178#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs767335178", "url": "http://gnomad.broadinstitute.org/awesome?query=rs767335178", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "I", "start_aa": "I", "up_seq": "DSSYMPSLVVVSGGNSLNNL", "down_seq": "ELKTININPSDTTVPLLNDC", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" }, { "id": "rs767335178", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs767335178" }, { "id": "rs767335178", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs767335178" }, { "id": "rs767335178", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs767335178#frequency_tab" }, { "id": "rs767335178", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs767335178" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "subjects_tested": "2617", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "I", "sequence_mut": "T", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (NLI->NLT).", "chr_id": "15", "chr_pos": "28191032", "ref_nt": "A", "alt_nt": "G", "minor_allelic_frequency": "", "site_lbl": "I2861", "disease": [ { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ], "unlinked_id_list": [ "DOID:1795" ], "evidence": [ { "id": "1793", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1793" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 20, "direction": "downstream", "id": "O95714-1.2841.2841", "categories": [ "snv_flag" ] }, { "distance": 9, "direction": "upstream", "id": "O95714-1.2870.2870", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2870.2870", "start_pos": 2870, "end_pos": 2870, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1284541506", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1284541506", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1284541506", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1284541506", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "P", "start_aa": "P", "up_seq": "VVSGGNSLNNLIELKTININ", "down_seq": "SDTTVPLLNDCTEYHRYIEI", "snv": [ { "evidence": [ { "id": "rs1284541506", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1284541506" }, { "id": "rs1284541506", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1284541506" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "P", "sequence_mut": "L", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (NPS->NLS).", "chr_id": "15", "chr_pos": "28191005", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P2870", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 9, "direction": "downstream", "id": "O95714-1.2861.2861", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2901.2901", "start_pos": 2901, "end_pos": 2901, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "CTEYHRYIEIAIKQCRSSGI", "down_seq": "CKIHGLILLGRIRAEEEDLA", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "4484", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28186701", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "D2901", "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "unlinked_id_list": [ "DOID:4765" ], "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.2928.2928", "start_pos": 2928, "end_pos": 2928, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [ { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" }, { "database": "iPTMnet", "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" }, { "database": "iPTMnet", "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.", "journal": "Cell", "date": "2006", "authors": "Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M", "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" }, { "database": "iPTMnet", "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714" } ], "reference": [ { "type": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" }, { "database": "iPTMnet", "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.", "journal": "Science signaling", "date": "2011", "authors": "Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B", "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" }, { "database": "iPTMnet", "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714" } ], "reference": [ { "type": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" } ] }, { "title": "Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications.", "journal": "Molecular & cellular proteomics : MCP", "date": "2007", "authors": "Sugiyama N, Masuda T, Shinoda K, Nakamura A, Tomita M, Ishihama Y", "evidence": [ { "database": "iPTMnet", "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714" } ], "reference": [ { "type": "PubMed", "id": "17322306", "url": "https://glygen.org/publication/PubMed/17322306" } ] }, { "title": "Phosphoproteome analysis of the human Chang liver cells using SCX and a complementary mass spectrometric strategy.", "journal": "Proteomics", "date": "2008", "authors": "Sui S, Wang J, Yang B, Song L, Zhang J, Chen M, Liu J, Lu Z, Cai Y, Chen S, Bi W, Zhu Y, He F, Qian X", "evidence": [ { "database": "iPTMnet", "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714" } ], "reference": [ { "type": "PubMed", "id": "18491316", "url": "https://glygen.org/publication/PubMed/18491316" } ] }, { "title": "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.", "journal": "Molecular cell", "date": "2008", "authors": "Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M", "evidence": [ { "database": "iPTMnet", "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714" } ], "reference": [ { "type": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] } ], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648", "database": "PubMed", "categories": [ "Other" ] }, { "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163", "database": "PubMed", "categories": [ "Other" ] }, { "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983", "database": "PubMed", "categories": [ "Other" ] }, { "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231", "database": "PubMed", "categories": [ "Other" ] }, { "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692", "database": "PubMed", "categories": [ "Other" ] }, { "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "17322306", "url": "https://glygen.org/publication/PubMed/17322306", "database": "PubMed", "categories": [ "Other" ] }, { "id": "18491316", "url": "https://glygen.org/publication/PubMed/18491316", "database": "PubMed", "categories": [ "Other" ] }, { "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976", "database": "PubMed", "categories": [ "Other" ] }, { "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "ILLGRIRAEEEDLAAVPFLA", "down_seq": "DNEEEEDEKGNSGSLIRKKA", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "4484", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "L", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28186619", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "S2928", "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "iPTMnet", "id": "O95714", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95714" }, { "database": "PubMed", "id": "17322306", "url": "https://glygen.org/publication/PubMed/17322306" }, { "database": "PubMed", "id": "18491316", "url": "https://glygen.org/publication/PubMed/18491316" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ], "site_lbl": "Ser2928" } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag", "phosphorylation_flag" ], "glycosylation": [], "mutagenesis": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 14, "direction": "upstream", "id": "O95714-1.2942.2942", "categories": [ "phosphorylation_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": true, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 9 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "O95714-1.3030.3030", "start_pos": 3030, "end_pos": 3030, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs201973387", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs201973387", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs201973387", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs201973387", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs201973387", "url": "https://www.ncbi.nlm.nih.gov/snp/rs201973387#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs201973387", "url": "http://gnomad.broadinstitute.org/awesome?query=rs201973387", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "EGKVYACGEATNGRLGLGIS", "down_seq": "GTVPIPRQITALSSYVVKKV", "snv": [ { "evidence": [ { "id": "rs201973387", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs201973387" }, { "id": "rs201973387", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs201973387" }, { "id": "rs201973387", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs201973387#frequency_tab" }, { "id": "rs201973387", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs201973387" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (SGT->NGT).", "chr_id": "15", "chr_pos": "28178961", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S3030", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3065.3065", "start_pos": 3065, "end_pos": 3065, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "YVVKKVAVHSGGRHATALTV", "down_seq": "GKVFSWGEGDDGKLGHFSRM", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "2003", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "Y", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28177480", "ref_nt": "C", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "D3065", "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "3571", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3571" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "unlinked_id_list": [ "DOID:4765" ], "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.328.328", "start_pos": 328, "end_pos": 328, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1334175429", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1334175429", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1334175429", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1334175429", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "SAILLLLQLWDSGAQETDNE", "down_seq": "SAQGTSAPLLPLLQRFQSII", "snv": [ { "evidence": [ { "id": "rs1334175429", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1334175429" }, { "id": "rs1334175429", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1334175429" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "R", "sequence_mut": "C", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (NER->NEC).", "chr_id": "15", "chr_pos": "28272316", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "R328", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "upstream", "id": "O95714-1.347.347", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3303.3303", "start_pos": 3303, "end_pos": 3303, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "V", "start_aa": "V", "up_seq": "DNDHGQQGNGTTTVNRKPTL", "down_seq": "QGLEGQKITRVACGSSHSVA", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "4484", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "V", "sequence_mut": "M", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28174545", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "V3303", "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ], "unlinked_id_list": [ "DOID:4203", "DOID:3541", "DOID:4706", "DOID:1659", "DOID:368" ], "evidence": [ { "id": "1319", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1319" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 7, "direction": "upstream", "id": "O95714-1.3310.3310", "categories": [ "snv_flag" ] }, { "distance": 10, "direction": "upstream", "id": "O95714-1.3313.3313", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3310.3310", "start_pos": 3310, "end_pos": 3310, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "GNGTTTVNRKPTLVQGLEGQ", "down_seq": "ITRVACGSSHSVAWTTVDVA", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "subjects_tested": "4799", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "K", "sequence_mut": "N", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (KIT->NIT).", "chr_id": "15", "chr_pos": "28174522", "ref_nt": "C", "alt_nt": "G", "minor_allelic_frequency": "", "site_lbl": "K3310", "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "unlinked_id_list": [ "DOID:4765" ], "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 7, "direction": "downstream", "id": "O95714-1.3303.3303", "categories": [ "snv_flag" ] }, { "distance": 3, "direction": "upstream", "id": "O95714-1.3313.3313", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3313.3313", "start_pos": 3313, "end_pos": 3313, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "TTTVNRKPTLVQGLEGQKIT", "down_seq": "VACGSSHSVAWTTVDVATPS", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "4484", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "H", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28174514", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "R3313", "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "unlinked_id_list": [ "DOID:4765" ], "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] }, { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "11054", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 10, "direction": "downstream", "id": "O95714-1.3303.3303", "categories": [ "snv_flag" ] }, { "distance": 3, "direction": "downstream", "id": "O95714-1.3310.3310", "categories": [ "snv_flag" ] }, { "distance": 18, "direction": "upstream", "id": "O95714-1.3331.3331", "categories": [ "glycosylation_flag", "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3374.3374", "start_pos": 3374, "end_pos": 3374, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1894489394", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1894489394", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1894489394", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1894489394#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "VPSDADSSAASNKISGASNS", "down_seq": "PNRPSLAKILLSLDGNLAKQ", "snv": [ { "evidence": [ { "id": "rs1894489394", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1894489394" }, { "id": "rs1894489394", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1894489394#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "K", "sequence_mut": "T", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (NSK->NST).", "chr_id": "15", "chr_pos": "28169592", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K3374", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3438.3438", "start_pos": 3438, "end_pos": 3438, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs763806394", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs763806394", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs763806394", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs763806394", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs763806394", "url": "https://www.ncbi.nlm.nih.gov/snp/rs763806394#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs763806394", "url": "http://gnomad.broadinstitute.org/awesome?query=rs763806394", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "MPAAMIAPVECPSFSSAAPS", "down_seq": "ASAMASPMNGEECMLAVDIE", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" }, { "id": "rs763806394", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs763806394" }, { "id": "rs763806394", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs763806394" }, { "id": "rs763806394", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs763806394#frequency_tab" }, { "id": "rs763806394", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs763806394" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "subjects_tested": "720", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (DAS->NAS).", "chr_id": "15", "chr_pos": "28168508", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "D3438", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.347.347", "start_pos": 347, "end_pos": 347, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs2140996910", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2140996910", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs2140996910", "url": "https://www.ensembl.org/id/rs2140996910", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "I", "start_aa": "I", "up_seq": "ERSAQGTSAPLLPLLQRFQS", "down_seq": "ICRKDAPHSEGDMHLLSGPL", "snv": [ { "evidence": [ { "id": "rs2140996910", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2140996910" }, { "id": "rs2140996910", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs2140996910" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "I", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (IIC->NIC).", "chr_id": "15", "chr_pos": "28272258", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I347", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "O95714-1.328.328", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3526.3526", "start_pos": 3526, "end_pos": 3526, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs765652137", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765652137", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs765652137", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765652137", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs765652137", "url": "http://gnomad.broadinstitute.org/awesome?query=rs765652137", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "A", "start_aa": "A", "up_seq": "ASIIAETMTKTKEDVESQNK", "down_seq": "AGPEPQALDEFTSLLIADDT", "snv": [ { "evidence": [ { "id": "rs765652137", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765652137" }, { "id": "rs765652137", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765652137" }, { "id": "rs765652137", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs765652137" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "A", "sequence_mut": "S", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (NKA->NKS).", "chr_id": "15", "chr_pos": "28163264", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A3526", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs765652137", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765652137" }, { "id": "rs765652137", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765652137" }, { "id": "rs765652137", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs765652137" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "A", "sequence_mut": "T", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (NKA->NKT).", "chr_id": "15", "chr_pos": "28163264", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A3526", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 17, "direction": "upstream", "id": "O95714-1.3543.3543", "categories": [ "snv_flag" ] }, { "distance": 18, "direction": "upstream", "id": "O95714-1.3544.3544", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3544.3544", "start_pos": 3544, "end_pos": 3544, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1289486718", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1289486718", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1289486718", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1289486718", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "NKAAGPEPQALDEFTSLLIA", "down_seq": "DTRVVVDLLKLSVCSRAGDR", "snv": [ { "evidence": [ { "id": "rs1289486718", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1289486718" }, { "id": "rs1289486718", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1289486718" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (DDT->NDT).", "chr_id": "15", "chr_pos": "28163210", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D3544", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 18, "direction": "downstream", "id": "O95714-1.3526.3526", "categories": [ "snv_flag" ] }, { "distance": 1, "direction": "downstream", "id": "O95714-1.3543.3543", "categories": [ "snv_flag" ] }, { "distance": 3, "direction": "upstream", "id": "O95714-1.3547.3547", "categories": [ "snv_flag" ] }, { "distance": 10, "direction": "upstream", "id": "O95714-1.3554.3554", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3547.3547", "start_pos": 3547, "end_pos": 3547, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "AGPEPQALDEFTSLLIADDT", "down_seq": "VVVDLLKLSVCSRAGDRGRD", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "4484", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "C", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28163201", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "R3547", "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "downstream", "id": "O95714-1.3543.3543", "categories": [ "snv_flag" ] }, { "distance": 3, "direction": "downstream", "id": "O95714-1.3544.3544", "categories": [ "snv_flag" ] }, { "distance": 7, "direction": "upstream", "id": "O95714-1.3554.3554", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3554.3554", "start_pos": 3554, "end_pos": 3554, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1342080194", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1342080194", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1342080194", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1342080194", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "K", "start_aa": "K", "up_seq": "LDEFTSLLIADDTRVVVDLL", "down_seq": "LSVCSRAGDRGRDVLSAVLS", "snv": [ { "evidence": [ { "id": "rs1342080194", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1342080194" }, { "id": "rs1342080194", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1342080194" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (KLS->NLS).", "chr_id": "15", "chr_pos": "28163178", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K3554", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 11, "direction": "downstream", "id": "O95714-1.3543.3543", "categories": [ "snv_flag" ] }, { "distance": 10, "direction": "downstream", "id": "O95714-1.3544.3544", "categories": [ "snv_flag" ] }, { "distance": 7, "direction": "downstream", "id": "O95714-1.3547.3547", "categories": [ "snv_flag" ] }, { "distance": 17, "direction": "upstream", "id": "O95714-1.3571.3571", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3571.3571", "start_pos": 3571, "end_pos": 3571, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "A", "start_aa": "A", "up_seq": "DLLKLSVCSRAGDRGRDVLS", "down_seq": "VLSGMGTAYPQVADMLLELC", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "719", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "A", "sequence_mut": "V", "comment": "Somatic mutation passed 1 filters: num. of cancers (5).", "chr_id": "15", "chr_pos": "28163128", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "A3571", "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ], "unlinked_id_list": [ "DOID:1542" ], "evidence": [ { "id": "11934", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11934" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "unlinked_id_list": [ "DOID:4765" ], "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 17, "direction": "downstream", "id": "O95714-1.3554.3554", "categories": [ "snv_flag" ] }, { "distance": 4, "direction": "upstream", "id": "O95714-1.3575.3575", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3575.3575", "start_pos": 3575, "end_pos": 3575, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "G", "start_aa": "G", "up_seq": "LSVCSRAGDRGRDVLSAVLS", "down_seq": "MGTAYPQVADMLLELCVTEL", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "719", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "G", "sequence_mut": "S", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28163117", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "G3575", "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ], "unlinked_id_list": [ "DOID:1542" ], "evidence": [ { "id": "11934", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11934" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "downstream", "id": "O95714-1.3571.3571", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3622.3622", "start_pos": 3622, "end_pos": 3622, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1407543642", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1407543642", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1407543642", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1407543642#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs1407543642", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1407543642", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "SQSGRLSSQPVVVESSHPYT", "down_seq": "DTSTSGTVKIPGAEGLRVEF", "snv": [ { "evidence": [ { "id": "rs1407543642", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1407543642" }, { "id": "rs1407543642", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1407543642#frequency_tab" }, { "id": "rs1407543642", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1407543642" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (DDT->NDT).", "chr_id": "15", "chr_pos": "28152713", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D3622", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 1, "direction": "upstream", "id": "O95714-1.3623.3623", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3623.3623", "start_pos": 3623, "end_pos": 3623, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1047573613", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1047573613", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1047573613", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1047573613#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs1047573613", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1047573613", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "QSGRLSSQPVVVESSHPYTD", "down_seq": "TSTSGTVKIPGAEGLRVEFD", "snv": [ { "evidence": [ { "id": "rs1047573613", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1047573613" }, { "id": "rs1047573613", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1047573613#frequency_tab" }, { "id": "rs1047573613", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1047573613" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (DTS->NTS).", "chr_id": "15", "chr_pos": "28152710", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D3623", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 1, "direction": "downstream", "id": "O95714-1.3622.3622", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3661.3661", "start_pos": 3661, "end_pos": 3661, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "V", "start_aa": "V", "up_seq": "EFDRQCSTERRHDPLTVMDG", "down_seq": "NRIVSVRSGREWSDWSSELR", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "4799", "subjects_positive": "2", "frequency": "0.0", "sequence_org": "V", "sequence_mut": "I", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28146264", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "V3661", "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "unlinked_id_list": [ "DOID:4765" ], "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "upstream", "id": "O95714-1.3665.3665", "categories": [ "snv_flag" ] }, { "distance": 5, "direction": "upstream", "id": "O95714-1.3666.3666", "categories": [ "snv_flag" ] }, { "distance": 14, "direction": "upstream", "id": "O95714-1.3675.3675", "categories": [ "snv_flag" ] }, { "distance": 20, "direction": "upstream", "id": "O95714-1.3681.3681", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3665.3665", "start_pos": 3665, "end_pos": 3665, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "V", "start_aa": "V", "up_seq": "QCSTERRHDPLTVMDGVNRI", "down_seq": "SVRSGREWSDWSSELRIPGD", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "3601", "subjects_positive": "3", "frequency": "0.1", "sequence_org": "V", "sequence_mut": "I", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28146252", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "V3665", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematological tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "blood cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:0081452", "DOID:706", "DOID:1039", "DOID:5604", "DOID:6536", "DOID:0080638", "DOID:7757", "DOID:0050743", "DOID:4960", "DOID:8527", "DOID:1036", "DOID:5772" ], "evidence": [ { "id": "2531", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2531" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "downstream", "id": "O95714-1.3661.3661", "categories": [ "snv_flag" ] }, { "distance": 1, "direction": "upstream", "id": "O95714-1.3666.3666", "categories": [ "snv_flag" ] }, { "distance": 10, "direction": "upstream", "id": "O95714-1.3675.3675", "categories": [ "snv_flag" ] }, { "distance": 16, "direction": "upstream", "id": "O95714-1.3681.3681", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3666.3666", "start_pos": 3666, "end_pos": 3666, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "CSTERRHDPLTVMDGVNRIV", "down_seq": "VRSGREWSDWSSELRIPGDE", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [ "o-glyco-site-loss" ], "subjects_tested": "2053", "subjects_positive": "5", "frequency": "0.2", "sequence_org": "S", "sequence_mut": "F", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28146248", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "S3666", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 5, "direction": "downstream", "id": "O95714-1.3661.3661", "categories": [ "snv_flag" ] }, { "distance": 1, "direction": "downstream", "id": "O95714-1.3665.3665", "categories": [ "snv_flag" ] }, { "distance": 9, "direction": "upstream", "id": "O95714-1.3675.3675", "categories": [ "snv_flag" ] }, { "distance": 15, "direction": "upstream", "id": "O95714-1.3681.3681", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3675.3675", "start_pos": 3675, "end_pos": 3675, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs754991203", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs754991203", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs754991203", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs754991203", "database": "ExAC", "categories": [ "Other" ] }, { "id": "rs754991203", "url": "https://www.ncbi.nlm.nih.gov/snp/rs754991203#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs754991203", "url": "http://gnomad.broadinstitute.org/awesome?query=rs754991203", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "LTVMDGVNRIVSVRSGREWS", "down_seq": "WSSELRIPGDELKWKFISDG", "snv": [ { "evidence": [ { "id": "rs754991203", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs754991203" }, { "id": "rs754991203", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs754991203" }, { "id": "rs754991203", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs754991203#frequency_tab" }, { "id": "rs754991203", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs754991203" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (DWS->NWS).", "chr_id": "15", "chr_pos": "28144790", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D3675", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 14, "direction": "downstream", "id": "O95714-1.3661.3661", "categories": [ "snv_flag" ] }, { "distance": 10, "direction": "downstream", "id": "O95714-1.3665.3665", "categories": [ "snv_flag" ] }, { "distance": 9, "direction": "downstream", "id": "O95714-1.3666.3666", "categories": [ "snv_flag" ] }, { "distance": 6, "direction": "upstream", "id": "O95714-1.3681.3681", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3681.3681", "start_pos": 3681, "end_pos": 3681, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "VNRIVSVRSGREWSDWSSEL", "down_seq": "IPGDELKWKFISDGSVNGWG", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "720", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "R", "sequence_mut": "C", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28144772", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "R3681", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 20, "direction": "downstream", "id": "O95714-1.3661.3661", "categories": [ "snv_flag" ] }, { "distance": 16, "direction": "downstream", "id": "O95714-1.3665.3665", "categories": [ "snv_flag" ] }, { "distance": 15, "direction": "downstream", "id": "O95714-1.3666.3666", "categories": [ "snv_flag" ] }, { "distance": 6, "direction": "downstream", "id": "O95714-1.3675.3675", "categories": [ "snv_flag" ] }, { "distance": 19, "direction": "upstream", "id": "O95714-1.3700.3700", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3700.3700", "start_pos": 3700, "end_pos": 3700, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "W", "start_aa": "W", "up_seq": "LRIPGDELKWKFISDGSVNG", "down_seq": "GWRFTVYPIMPAAGPKELLS", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "subjects_tested": "3601", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "W", "sequence_mut": "C", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (NGW->NGC).", "chr_id": "15", "chr_pos": "28144713", "ref_nt": "C", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "W3700", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 19, "direction": "downstream", "id": "O95714-1.3681.3681", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3721.3721", "start_pos": 3721, "end_pos": 3721, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "D", "start_aa": "D", "up_seq": "GWRFTVYPIMPAAGPKELLS", "down_seq": "RCVLSCPSMDLVTCLLDFRL", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "subjects_tested": "2053", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (DRC->NRC).", "chr_id": "15", "chr_pos": "28144215", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "D3721", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3744.3744", "start_pos": 3744, "end_pos": 3744, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1315814960", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1315814960", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1315814960", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1315814960#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs1315814960", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1315814960", "database": "gnomAD", "categories": [ "Other" ] }, { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "A", "start_aa": "A", "up_seq": "VLSCPSMDLVTCLLDFRLNL", "down_seq": "SNRSIVPRLAASLAACAQLS", "snv": [ { "evidence": [ { "id": "rs1315814960", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1315814960" }, { "id": "rs1315814960", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1315814960#frequency_tab" }, { "id": "rs1315814960", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1315814960" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_org": "A", "sequence_mut": "S", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (NLA->NLS).", "chr_id": "15", "chr_pos": "28144146", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A3744", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "subjects_tested": "320", "subjects_positive": "1", "frequency": "0.3", "sequence_org": "A", "sequence_mut": "T", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (NLA->NLT).", "chr_id": "15", "chr_pos": "28144146", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "A3744", "disease": [ { "disease_id": "DOID:4362", "recommended_name": { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervical cancer", "description": "A female reproductive organ cancer that is located_in the cervix." }, "synonyms": [ { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervical neoplasm", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervix cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervix uteri cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "neoplasm of uterine cervix", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "tumor of the Cervix Uteri", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer", "description": "A primary or metastatic malignant neoplasm involving the cervix." }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cancer of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer, somatic", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervix cancer", "description": "" }, { "id": "MIM:603956", "resource": "MIM", "url": "https://www.omim.org/entry/603956", "name": "Cervical cancer", "description": "Cervical cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "4362", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4362" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 2, "direction": "upstream", "id": "O95714-1.3746.3746", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 4, "direction": "upstream", "id": "O95714-1.3748.3748", "categories": [ "snv_flag" ] }, { "distance": 10, "direction": "upstream", "id": "O95714-1.3754.3754", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3748.3748", "start_pos": 3748, "end_pos": 3748, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1250585808", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1250585808", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1250585808", "url": "https://www.ensembl.org/id/rs1250585808", "database": "ENSEMBL", "categories": [ "Other" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "PSMDLVTCLLDFRLNLASNR", "down_seq": "IVPRLAASLAACAQLSALAA", "snv": [ { "evidence": [ { "id": "rs1250585808", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1250585808" }, { "id": "rs1250585808", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1250585808" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-loss (NRS->NRN).", "chr_id": "15", "chr_pos": "28144133", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S3748", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 4, "direction": "downstream", "id": "O95714-1.3744.3744", "categories": [ "snv_flag" ] }, { "distance": 2, "direction": "downstream", "id": "O95714-1.3746.3746", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 6, "direction": "upstream", "id": "O95714-1.3754.3754", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3754.3754", "start_pos": 3754, "end_pos": 3754, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "A", "start_aa": "A", "up_seq": "TCLLDFRLNLASNRSIVPRL", "down_seq": "ASLAACAQLSALAASHRMWA", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "4484", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "A", "sequence_mut": "V", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "15", "chr_pos": "28144115", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "A3754", "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ], "unlinked_id_list": [ "DOID:4203", "DOID:3541", "DOID:4706", "DOID:1659", "DOID:368" ], "evidence": [ { "id": "1319", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1319" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 10, "direction": "downstream", "id": "O95714-1.3744.3744", "categories": [ "snv_flag" ] }, { "distance": 8, "direction": "downstream", "id": "O95714-1.3746.3746", "categories": [ "glycosylation_flag", "snv_flag" ] }, { "distance": 6, "direction": "downstream", "id": "O95714-1.3748.3748", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3793.3793", "start_pos": 3793, "end_pos": 3793, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "rs1486170977", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1486170977", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1486170977", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1486170977", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "N", "start_aa": "N", "up_seq": "WALQRLRKLLTTEFGQSINI", "down_seq": "RLLGENDGETRALSFTGSAL", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" }, { "id": "rs1486170977", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1486170977" }, { "id": "rs1486170977", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1486170977" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "subjects_tested": "3601", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "N", "sequence_mut": "S", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (NIN->NIS).", "chr_id": "15", "chr_pos": "28143913", "ref_nt": "T", "alt_nt": "C", "minor_allelic_frequency": "", "site_lbl": "N3793", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] }, { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ], "unlinked_id_list": [ "DOID:4203", "DOID:3541", "DOID:4706", "DOID:1659", "DOID:368" ], "evidence": [ { "id": "1319", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1319" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 14, "direction": "upstream", "id": "O95714-1.3807.3807", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3807.3807", "start_pos": 3807, "end_pos": 3807, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "S", "start_aa": "S", "up_seq": "GQSININRLLGENDGETRAL", "down_seq": "FTGSALAALVKGLPEALQRQ", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "subjects_tested": "2670", "subjects_positive": "1", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "N", "comment": "Somatic mutation passed 1 filters: n-glyco-sequon-gain (SFT->NFT).", "chr_id": "15", "chr_pos": "28142951", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "S3807", "disease": [ { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ], "unlinked_id_list": [ "DOID:4203", "DOID:3541", "DOID:4706", "DOID:1659", "DOID:368" ], "evidence": [ { "id": "1319", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1319" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 14, "direction": "downstream", "id": "O95714-1.3793.3793", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3906.3906", "start_pos": 3906, "end_pos": 3906, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "ALDKRTPLPRLFLDEVAKKI", "down_seq": "ELMADSENMDVLHESHDIFK", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "1704", "subjects_positive": "6", "frequency": "0.4", "sequence_org": "R", "sequence_mut": "C", "comment": "Somatic mutation passed 1 filters: num. of cancers (7).", "chr_id": "15", "chr_pos": "28141831", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "R3906", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ], "unlinked_id_list": [ "DOID:4203", "DOID:3541", "DOID:4706", "DOID:1659", "DOID:368" ], "evidence": [ { "id": "1319", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1319" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3940.3940", "start_pos": 3940, "end_pos": 3940, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "O95714", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714", "database": "BioMuta", "categories": [ "Variation" ] } ], "site_seq": "R", "start_aa": "R", "up_seq": "ESHDIFKREQDEQLVQWMNR", "down_seq": "PDDWTLSAGGSGTIYGWGHN", "snv": [ { "evidence": [ { "id": "O95714", "database": "BioMuta", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/O95714" } ], "glycoeffect": [], "subjects_tested": "720", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "R", "sequence_mut": "*", "comment": "Somatic mutation passed 1 filters: num. of cancers (5).", "chr_id": "15", "chr_pos": "28141629", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "R3940", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:4362", "recommended_name": { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervical cancer", "description": "A female reproductive organ cancer that is located_in the cervix." }, "synonyms": [ { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervical neoplasm", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervix cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervix uteri cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "neoplasm of uterine cervix", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "tumor of the Cervix Uteri", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer", "description": "A primary or metastatic malignant neoplasm involving the cervix." }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cancer of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer, somatic", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervix cancer", "description": "" }, { "id": "MIM:603956", "resource": "MIM", "url": "https://www.omim.org/entry/603956", "name": "Cervical cancer", "description": "Cervical cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "4362", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4362" } ] }, { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "unlinked_id_list": [ "DOID:4765" ], "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 5, "direction": "upstream", "id": "O95714-1.3945.3945", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "id": "O95714-1.3945.3945", "start_pos": 3945, "end_pos": 3945, "uniprot_canonical_ac": "O95714-1", "length": 4834, "uniprot_id": "HERC2_HUMAN", "protein_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": "NP_004658", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528", "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95714", "url": "https://www.uniprot.org/uniprotkb/O95714" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "publication": [], "crossref": [ { "id": "rs1268524670", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1268524670", "database": "dbSNP", "categories": [ "Other" ] }, { "id": "rs1268524670", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1268524670#frequency_tab", "database": "TOPMed", "categories": [ "Other" ] }, { "id": "rs1268524670", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1268524670", "database": "gnomAD", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "FKREQDEQLVQWMNRRPDDW", "down_seq": "LSAGGSGTIYGWGHNHRGQL", "snv": [ { "evidence": [ { "id": "rs1268524670", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1268524670" }, { "id": "rs1268524670", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1268524670#frequency_tab" }, { "id": "rs1268524670", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1268524670" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (TLS->NLS).", "chr_id": "15", "chr_pos": "28141613", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T3945", "keywords": [ "ebi", "germline" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "1370", "end_pos": "1370" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "2790", "end_pos": "2790" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "4022", "end_pos": "4022" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4182", "end_pos": "4182" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "mutagenesis", "site_list": [ { "start_pos": "2708", "end_pos": "2708" }, { "start_pos": "2711", "end_pos": "2711" }, { "start_pos": "4827", "end_pos": "4827" } ] }, { "type": "snv", "site_list": [ { "start_pos": "3487", "end_pos": "3487" }, { "start_pos": "3543", "end_pos": "3543" }, { "start_pos": "4628", "end_pos": "4628" }, { "start_pos": "1020", "end_pos": "1020" }, { "start_pos": "1056", "end_pos": "1056" }, { "start_pos": "1059", "end_pos": "1059" }, { "start_pos": "1076", "end_pos": "1076" }, { "start_pos": "1150", "end_pos": "1150" }, { "start_pos": "1198", "end_pos": "1198" }, { "start_pos": "11", "end_pos": "11" }, { "start_pos": "1211", "end_pos": "1211" }, { "start_pos": "1310", "end_pos": "1310" }, { "start_pos": "1318", "end_pos": "1318" }, { "start_pos": "1362", "end_pos": "1362" }, { "start_pos": "1386", "end_pos": "1386" }, { "start_pos": "1400", "end_pos": "1400" }, { "start_pos": "1428", "end_pos": "1428" }, { "start_pos": "1479", "end_pos": "1479" }, { "start_pos": "1542", "end_pos": "1542" }, { "start_pos": "1552", "end_pos": "1552" }, { "start_pos": "1656", "end_pos": "1656" }, { "start_pos": "1668", "end_pos": "1668" }, { "start_pos": "1725", "end_pos": "1725" }, { "start_pos": "1744", "end_pos": "1744" }, { "start_pos": "1771", "end_pos": "1771" }, { "start_pos": "1772", "end_pos": "1772" }, { "start_pos": "179", "end_pos": "179" }, { "start_pos": "1809", "end_pos": "1809" }, { "start_pos": "1851", "end_pos": "1851" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1951", "end_pos": "1951" }, { "start_pos": "1990", "end_pos": "1990" }, { "start_pos": "2003", "end_pos": "2003" }, { "start_pos": "2031", "end_pos": "2031" }, { "start_pos": "2046", "end_pos": "2046" }, { "start_pos": "2085", "end_pos": "2085" }, { "start_pos": "2143", "end_pos": "2143" }, { "start_pos": "2151", "end_pos": "2151" }, { "start_pos": "2184", "end_pos": "2184" }, { "start_pos": "2185", "end_pos": "2185" }, { "start_pos": "2189", "end_pos": "2189" }, { "start_pos": "219", "end_pos": "219" }, { "start_pos": "2232", "end_pos": "2232" }, { "start_pos": "2274", "end_pos": "2274" }, { "start_pos": "2290", "end_pos": "2290" }, { "start_pos": "2300", "end_pos": "2300" }, { "start_pos": "2333", "end_pos": "2333" }, { "start_pos": "2353", "end_pos": "2353" }, { "start_pos": "242", "end_pos": "242" }, { "start_pos": "2504", "end_pos": "2504" }, { "start_pos": "2546", "end_pos": "2546" }, { "start_pos": "2630", "end_pos": "2630" }, { "start_pos": "2674", "end_pos": "2674" }, { "start_pos": "2707", "end_pos": "2707" }, { "start_pos": "274", "end_pos": "274" }, { "start_pos": "2757", "end_pos": "2757" }, { "start_pos": "2762", "end_pos": "2762" }, { "start_pos": "2768", "end_pos": "2768" }, { "start_pos": "2781", "end_pos": "2781" }, { "start_pos": "2792", "end_pos": "2792" }, { "start_pos": "2798", "end_pos": "2798" }, { "start_pos": "2841", "end_pos": "2841" }, { "start_pos": "2861", "end_pos": "2861" }, { "start_pos": "2870", "end_pos": "2870" }, { "start_pos": "2901", "end_pos": "2901" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "3030", "end_pos": "3030" }, { "start_pos": "3065", "end_pos": "3065" }, { "start_pos": "3136", "end_pos": "3136" }, { "start_pos": "328", "end_pos": "328" }, { "start_pos": "3303", "end_pos": "3303" }, { "start_pos": "3310", "end_pos": "3310" }, { "start_pos": "3313", "end_pos": "3313" }, { "start_pos": "3331", "end_pos": "3331" }, { "start_pos": "3374", "end_pos": "3374" }, { "start_pos": "3438", "end_pos": "3438" }, { "start_pos": "3475", "end_pos": "3475" }, { "start_pos": "347", "end_pos": "347" }, { "start_pos": "3485", "end_pos": "3485" }, { "start_pos": "3526", "end_pos": "3526" }, { "start_pos": "3544", "end_pos": "3544" }, { "start_pos": "3547", "end_pos": "3547" }, { "start_pos": "3554", "end_pos": "3554" }, { "start_pos": "3571", "end_pos": "3571" }, { "start_pos": "3575", "end_pos": "3575" }, { "start_pos": "3622", "end_pos": "3622" }, { "start_pos": "3623", "end_pos": "3623" }, { "start_pos": "3661", "end_pos": "3661" }, { "start_pos": "3665", "end_pos": "3665" }, { "start_pos": "3666", "end_pos": "3666" }, { "start_pos": "3675", "end_pos": "3675" }, { "start_pos": "3681", "end_pos": "3681" }, { "start_pos": "3700", "end_pos": "3700" }, { "start_pos": "3721", "end_pos": "3721" }, { "start_pos": "3744", "end_pos": "3744" }, { "start_pos": "3746", "end_pos": "3746" }, { "start_pos": "3748", "end_pos": "3748" }, { "start_pos": "3754", "end_pos": "3754" }, { "start_pos": "3793", "end_pos": "3793" }, { "start_pos": "3807", "end_pos": "3807" }, { "start_pos": "3906", "end_pos": "3906" }, { "start_pos": "3940", "end_pos": "3940" }, { "start_pos": "3945", "end_pos": "3945" }, { "start_pos": "4029", "end_pos": "4029" }, { "start_pos": "4075", "end_pos": "4075" }, { "start_pos": "4077", "end_pos": "4077" }, { "start_pos": "4183", "end_pos": "4183" }, { "start_pos": "4213", "end_pos": "4213" }, { "start_pos": "4238", "end_pos": "4238" }, { "start_pos": "4283", "end_pos": "4283" }, { "start_pos": "4355", "end_pos": "4355" }, { "start_pos": "4372", "end_pos": "4372" }, { "start_pos": "4374", "end_pos": "4374" }, { "start_pos": "4401", "end_pos": "4401" }, { "start_pos": "4410", "end_pos": "4410" }, { "start_pos": "4438", "end_pos": "4438" }, { "start_pos": "4476", "end_pos": "4476" }, { "start_pos": "4650", "end_pos": "4650" }, { "start_pos": "4716", "end_pos": "4716" }, { "start_pos": "471", "end_pos": "471" }, { "start_pos": "4726", "end_pos": "4726" }, { "start_pos": "4769", "end_pos": "4769" }, { "start_pos": "4808", "end_pos": "4808" }, { "start_pos": "4809", "end_pos": "4809" }, { "start_pos": "4812", "end_pos": "4812" }, { "start_pos": "543", "end_pos": "543" }, { "start_pos": "559", "end_pos": "559" }, { "start_pos": "561", "end_pos": "561" }, { "start_pos": "581", "end_pos": "581" }, { "start_pos": "594", "end_pos": "594" }, { "start_pos": "737", "end_pos": "737" }, { "start_pos": "886", "end_pos": "886" }, { "start_pos": "984", "end_pos": "984" }, { "start_pos": "995", "end_pos": "995" } ] }, { "type": "phosphorylation", "site_list": [ { "start_pos": "1577", "end_pos": "1577" }, { "start_pos": "1938", "end_pos": "1938" }, { "start_pos": "1942", "end_pos": "1942" }, { "start_pos": "1944", "end_pos": "1944" }, { "start_pos": "1948", "end_pos": "1948" }, { "start_pos": "2454", "end_pos": "2454" }, { "start_pos": "272", "end_pos": "272" }, { "start_pos": "2928", "end_pos": "2928" }, { "start_pos": "2942", "end_pos": "2942" }, { "start_pos": "4687", "end_pos": "4687" }, { "start_pos": "4690", "end_pos": "4690" }, { "start_pos": "4710", "end_pos": "4710" }, { "start_pos": "4810", "end_pos": "4810" }, { "start_pos": "4811", "end_pos": "4811" }, { "start_pos": "4814", "end_pos": "4814" }, { "start_pos": "4827", "end_pos": "4827" }, { "start_pos": "647", "end_pos": "647" } ] } ], "categories": [ "snv_flag" ], "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "biomarkers": [], "neighbors": [ { "distance": 5, "direction": "downstream", "id": "O95714-1.3940.3940", "categories": [ "snv_flag" ] } ], "glycosylation_flag": false, "snv_flag": true, "mutagenesis_flag": false, "phosphorylation_flag": false, "glycation_flag": false, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] } ]