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sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q13237", "url": "https://www.uniprot.org/uniprotkb/Q13237" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.7498513", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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[] } ] }, { "title": "6-Pyruvoyl tetrahydropterin synthase, an enzyme with a novel type of active site involving both zinc binding and an intersubunit catalytic triad motif; site-directed mutagenesis of the proposed active center, characterization of the metal binding site and modelling of substrate binding.", "journal": "Journal of molecular biology", "date": "1995", "authors": "Burgisser DM, Thony B, Redweik U, Hess D, Heizmann CW, Huber R, Nar H", "reference": { "type": "PubMed", "id": "7563095", "url": "https://pubmed.ncbi.nlm.nih.gov/7563095" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q13237-1", "protein_name": "cGMP-dependent protein kinase 2", "gene_name": "PRKG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0DP23-1", "protein_name": "Calmodulin-1", "gene_name": "CALM1; CALM2; CALM3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30793-1", "protein_name": "GTP cyclohydrolase 1", "gene_name": "GCH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P29474-1", "protein_name": "Nitric oxide synthase 3", "gene_name": "NOS3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31749-1", "protein_name": "RAC-alpha serine/threonine-protein kinase", "gene_name": "AKT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07900-1", "protein_name": "Heat shock protein HSP 90-alpha", "gene_name": "HSP90AA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q03393-1", "protein_name": "6-pyruvoyl tetrahydrobiopterin synthase", "gene_name": "PTS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30047-1", "protein_name": "GTP cyclohydrolase 1 feedback regulatory protein", "gene_name": "GCHFR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00374-1", "protein_name": "Dihydrofolate reductase", "gene_name": "DHFR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35270-1", "protein_name": "Sepiapterin reductase", "gene_name": "SPR", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q13237", "url": "https://www.uniprot.org/uniprotkb/Q13237" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.7563095", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 10 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 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"Atomic structure of GTP cyclohydrolase I.", "journal": "Structure (London, England : 1993)", "date": "1995", "authors": "Nar H, Huber R, Meining W, Schmid C, Weinkauf S, Bacher A", "reference": { "type": "PubMed", "id": "7663943", "url": "https://pubmed.ncbi.nlm.nih.gov/7663943" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q13237-1", "protein_name": "cGMP-dependent protein kinase 2", "gene_name": "PRKG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0DP23-1", "protein_name": "Calmodulin-1", "gene_name": "CALM1; CALM2; CALM3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30793-1", "protein_name": "GTP cyclohydrolase 1", "gene_name": "GCH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P29474-1", "protein_name": "Nitric oxide synthase 3", "gene_name": "NOS3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31749-1", "protein_name": "RAC-alpha serine/threonine-protein kinase", "gene_name": "AKT1", "tax_name": "Human" }, { 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"uniprot_canonical_ac": "P30047-1", "protein_name": "GTP cyclohydrolase 1 feedback regulatory protein", "gene_name": "GCHFR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00374-1", "protein_name": "Dihydrofolate reductase", "gene_name": "DHFR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35270-1", "protein_name": "Sepiapterin reductase", "gene_name": "SPR", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q13237", "url": "https://www.uniprot.org/uniprotkb/Q13237" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.8137809", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 11 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { 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"P00374-1", "protein_name": "Dihydrofolate reductase", "gene_name": "DHFR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35270-1", "protein_name": "Sepiapterin reductase", "gene_name": "SPR", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q13237", "url": "https://www.uniprot.org/uniprotkb/Q13237" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.8137944", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 10 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", 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"field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { 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Modified cysteine residues inhibit the enzyme activity.", "journal": "European journal of biochemistry", "date": "1994", "authors": "Burgisser DM, Thony B, Redweik U, Hunziker P, Heizmann CW, Blau N", "reference": { "type": "PubMed", "id": "8307017", "url": "https://pubmed.ncbi.nlm.nih.gov/8307017" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q13237-1", "protein_name": "cGMP-dependent protein kinase 2", "gene_name": "PRKG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0DP23-1", "protein_name": "Calmodulin-1", "gene_name": "CALM1; CALM2; CALM3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30793-1", "protein_name": "GTP cyclohydrolase 1", "gene_name": "GCH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P29474-1", "protein_name": "Nitric oxide synthase 3", "gene_name": "NOS3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31749-1", "protein_name": "RAC-alpha serine/threonine-protein kinase", "gene_name": "AKT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07900-1", "protein_name": "Heat shock protein HSP 90-alpha", "gene_name": "HSP90AA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q03393-1", "protein_name": "6-pyruvoyl tetrahydrobiopterin synthase", "gene_name": "PTS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30047-1", "protein_name": "GTP cyclohydrolase 1 feedback regulatory protein", "gene_name": "GCHFR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00374-1", "protein_name": "Dihydrofolate reductase", "gene_name": "DHFR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35270-1", "protein_name": "Sepiapterin reductase", "gene_name": "SPR", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q13237", "url": "https://www.uniprot.org/uniprotkb/Q13237" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.8307017", "abstract": "", 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F-box and WD repeat domain-containing 7alpha (FBW7alpha).", "journal": "The Journal of biological chemistry", "date": "2014", "authors": "Bialkowska AB, Liu Y, Nandan MO, Yang VW", "reference": { "type": "PubMed", "id": "24398687", "url": "https://pubmed.ncbi.nlm.nih.gov/24398687" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q13887-1", "protein_name": "Krueppel-like factor 5", "gene_name": "KLF5", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q13887", "url": "https://www.uniprot.org/uniprotkb/Q13887" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "phosphorylation": [ { "start_pos": 303, "end_pos": 303, "kinase_uniprot_canonical_ac": "P49841-1", "kinase_gene_name": "GSK3B", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q13887", "url": 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], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "A transcription map of the 6p22.3 reading disability locus identifying candidate genes.", "journal": "BMC Genomics", "date": "2003", "authors": "Londin Eric R, Meng Haiying, Gruen Jeffrey R", "reference": { "type": "PubMed", "id": "12834540", "url": "https://pubmed.ncbi.nlm.nih.gov/12834540" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q5VV43-1", "protein_name": "Dyslexia-associated protein KIAA0319", "gene_name": "KIAA0319", "tax_name": "Human" } ], "species": [ { 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"count": 0 } ], "sort_fields": [] } ] }, { "title": "Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia.", "journal": "American journal of human genetics", "date": "2005", "authors": "Cope N, Harold D, Hill G, Moskvina V, Stevenson J, Holmans P, Owen MJ, O'Donovan MC, Williams J", "reference": { "type": "PubMed", "id": "15717286", "url": "https://pubmed.ncbi.nlm.nih.gov/15717286" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q5VV43-1", "protein_name": "Dyslexia-associated protein KIAA0319", "gene_name": "KIAA0319", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q5VV43", "url": "https://www.uniprot.org/uniprotkb/Q5VV43" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.15717286", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], 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Genome", "date": "2007", "authors": "Velayos-Baeza Antonio, Toma Claudio, da Roza Stephanie, Paracchini Silvia, Monaco Anthony P", "reference": { "type": "PubMed", "id": "17846832", "url": "https://pubmed.ncbi.nlm.nih.gov/17846832" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q5VV43-1", "protein_name": "Dyslexia-associated protein KIAA0319", "gene_name": "KIAA0319", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q5VV43", "url": "https://www.uniprot.org/uniprotkb/Q5VV43" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.17846832", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", 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], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The dyslexia-associated gene KIAA0319 encodes highly N- and O-glycosylated plasma membrane and secreted isoforms.", "journal": "Human molecular genetics", "date": "2008", "authors": "Velayos-Baeza A, Toma C, Paracchini S, Monaco AP", "reference": { "type": "PubMed", "id": "18063668", "url": "https://pubmed.ncbi.nlm.nih.gov/18063668" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q5VV43-1", "protein_name": "Dyslexia-associated protein KIAA0319", "gene_name": "KIAA0319", 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Cell physiology", "date": "2009", "authors": "Levecque C, Velayos-Baeza A, Holloway ZG, Monaco AP", "reference": { "type": "PubMed", "id": "19419997", "url": "https://pubmed.ncbi.nlm.nih.gov/19419997" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q5VV43-1", "protein_name": "Dyslexia-associated protein KIAA0319", "gene_name": "KIAA0319", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96CW1-1", "protein_name": "AP-2 complex subunit mu", "gene_name": "AP2M1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q5VV43", "url": "https://www.uniprot.org/uniprotkb/Q5VV43" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 995, "end_pos": 995, "sequence_org": "Y", "sequence_mut": "A", "comment": "Loss of interaction with AP2M1 and impaired endocytosis.", "evidence": [ { "database": "UniProtKB", "id": 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Cell Sci.", "date": "2012", "authors": "Roboti P, High S", "reference": { "type": "PubMed", "id": "22266900", "url": "https://pubmed.ncbi.nlm.nih.gov/22266900" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8N6L1-1", "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2", "gene_name": "KRTCAP2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8N6L1", "url": "https://www.uniprot.org/uniprotkb/Q8N6L1" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.22266900", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { 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B, Biointerfaces", "date": "2023-02", "authors": "Sun Pingping, Zhang Hui, Shi Jiawen, Xu Manyu, Cheng Tong, Lu Bing, Yang Lei, Zhang Xiaojing, Huang Jianfei", "reference": { "type": "PubMed", "id": "36634487", "url": "https://pubmed.ncbi.nlm.nih.gov/36634487" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8N6L1-1", "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2", "gene_name": "KRTCAP2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8N6L1", "url": "https://www.uniprot.org/uniprotkb/Q8N6L1" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.36634487", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 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0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "CircKDM1B promotes hepatocellular carcinoma progression through regulating miR-1322/PRC1 axis.", "journal": "Environmental toxicology", "date": "2023-08", "authors": "Yi Mo, Lv Samei, He Yu, Wu Youwei, Zhang Jian, Chen Qian", "reference": { "type": "PubMed", "id": "37227723", "url": "https://pubmed.ncbi.nlm.nih.gov/37227723" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NB78-1", "protein_name": "Lysine-specific histone demethylase 2", "gene_name": "KDM1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43663-1", "protein_name": "Protein regulator of cytokinesis 1", "gene_name": "PRC1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NB78", "url": "https://www.uniprot.org/uniprotkb/Q8NB78" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.37227723", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], 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"o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "A new secreted protein that binds to Wnt proteins and inhibits their activities.", "journal": "Nature", "date": "1999", "authors": "Hsieh JC, Kodjabachian L, Rebbert ML, Rattner A, Smallwood PM, Samos CH, Nusse R, Dawid IB, Nathans J", "reference": { "type": "PubMed", "id": "10201374", "url": "https://pubmed.ncbi.nlm.nih.gov/10201374" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BQB4-1", "protein_name": "Sclerostin", "gene_name": "SOST", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9W6F9-1", "protein_name": "Wnt inhibitory factor 1", "gene_name": "wif1", "tax_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q96HF1-1", "protein_name": "Secreted frizzled-related protein 2", "gene_name": "SFRP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBU2-1", "protein_name": "Dickkopf-related protein 2", "gene_name": "DKK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94907-1", "protein_name": "Dickkopf-related protein 1", "gene_name": "DKK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MU8-1", "protein_name": "Kremen protein 1", "gene_name": "KREMEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9WUA1-1", "protein_name": "Wnt inhibitory factor 1", "gene_name": "Wif1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N474-1", "protein_name": "Secreted frizzled-related protein 1", "gene_name": "SFRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75581-1", "protein_name": "Low-density lipoprotein receptor-related protein 6", "gene_name": "LRP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75197-1", "protein_name": "Low-density lipoprotein receptor-related protein 5", "gene_name": "LRP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56704-1", "protein_name": "Protein Wnt-3a", "gene_name": "WNT3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5W5-1", "protein_name": "Wnt inhibitory factor 1", "gene_name": "WIF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56705-1", "protein_name": "Protein Wnt-4", "gene_name": "WNT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41221-1", "protein_name": "Protein Wnt-5a", "gene_name": "WNT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14904-1", "protein_name": "Protein Wnt-9a", "gene_name": "WNT9A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBT3-1", "protein_name": "Dickkopf-related protein 4", "gene_name": "DKK4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NCW0", "url": "https://www.uniprot.org/uniprotkb/Q8NCW0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10201374", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 17 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Bafico A, Gazit A, Pramila T, Finch PW, Yaniv A, Aaronson SA", "reference": { "type": "PubMed", "id": "10347172", "url": "https://pubmed.ncbi.nlm.nih.gov/10347172" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BQB4-1", "protein_name": "Sclerostin", "gene_name": "SOST", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96HF1-1", "protein_name": "Secreted frizzled-related protein 2", "gene_name": "SFRP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBU2-1", "protein_name": "Dickkopf-related protein 2", "gene_name": "DKK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94907-1", "protein_name": "Dickkopf-related protein 1", "gene_name": "DKK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MU8-1", "protein_name": "Kremen protein 1", "gene_name": "KREMEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N474-1", "protein_name": "Secreted frizzled-related protein 1", "gene_name": "SFRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75581-1", "protein_name": "Low-density lipoprotein receptor-related protein 6", "gene_name": "LRP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75197-1", "protein_name": "Low-density lipoprotein receptor-related protein 5", "gene_name": "LRP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56704-1", "protein_name": "Protein Wnt-3a", "gene_name": "WNT3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5W5-1", "protein_name": "Wnt inhibitory factor 1", "gene_name": "WIF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56705-1", "protein_name": "Protein Wnt-4", "gene_name": "WNT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41221-1", "protein_name": "Protein Wnt-5a", "gene_name": "WNT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14904-1", "protein_name": "Protein Wnt-9a", "gene_name": "WNT9A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBT3-1", "protein_name": "Dickkopf-related protein 4", "gene_name": "DKK4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NCW0", "url": "https://www.uniprot.org/uniprotkb/Q8NCW0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10347172", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 15 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling.", "journal": "Current biology : CB", "date": "2000", "authors": "Wu W, Glinka A, Delius H, Niehrs C", "reference": { "type": "PubMed", "id": "11137016", "url": "https://pubmed.ncbi.nlm.nih.gov/11137016" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BQB4-1", "protein_name": "Sclerostin", "gene_name": "SOST", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96HF1-1", "protein_name": "Secreted frizzled-related protein 2", "gene_name": "SFRP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBU2-1", "protein_name": "Dickkopf-related protein 2", "gene_name": "DKK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94907-1", "protein_name": "Dickkopf-related protein 1", "gene_name": "DKK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MU8-1", "protein_name": "Kremen protein 1", "gene_name": "KREMEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N474-1", "protein_name": "Secreted frizzled-related protein 1", "gene_name": "SFRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75581-1", "protein_name": "Low-density lipoprotein receptor-related protein 6", "gene_name": "LRP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75197-1", "protein_name": "Low-density lipoprotein receptor-related protein 5", "gene_name": "LRP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56704-1", "protein_name": "Protein Wnt-3a", "gene_name": "WNT3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5W5-1", "protein_name": "Wnt inhibitory factor 1", "gene_name": "WIF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56705-1", "protein_name": "Protein Wnt-4", "gene_name": "WNT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41221-1", "protein_name": "Protein Wnt-5a", "gene_name": "WNT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14904-1", "protein_name": "Protein Wnt-9a", "gene_name": "WNT9A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBT3-1", "protein_name": "Dickkopf-related protein 4", "gene_name": "DKK4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NCW0", "url": "https://www.uniprot.org/uniprotkb/Q8NCW0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11137016", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 15 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { 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"Secreted frizzled-related protein 2", "gene_name": "SFRP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBU2-1", "protein_name": "Dickkopf-related protein 2", "gene_name": "DKK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94907-1", "protein_name": "Dickkopf-related protein 1", "gene_name": "DKK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MU8-1", "protein_name": "Kremen protein 1", "gene_name": "KREMEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N474-1", "protein_name": "Secreted frizzled-related protein 1", "gene_name": "SFRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75581-1", "protein_name": "Low-density lipoprotein receptor-related protein 6", "gene_name": "LRP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75197-1", "protein_name": "Low-density lipoprotein receptor-related protein 5", "gene_name": "LRP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56704-1", "protein_name": "Protein Wnt-3a", "gene_name": "WNT3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5W5-1", "protein_name": "Wnt inhibitory factor 1", "gene_name": "WIF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56705-1", "protein_name": "Protein Wnt-4", "gene_name": "WNT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41221-1", "protein_name": "Protein Wnt-5a", "gene_name": "WNT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14904-1", "protein_name": "Protein Wnt-9a", "gene_name": "WNT9A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBT3-1", "protein_name": "Dickkopf-related protein 4", "gene_name": "DKK4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NCW0", "url": "https://www.uniprot.org/uniprotkb/Q8NCW0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11433302", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], 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0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Li L, Mao J, Sun L, Liu W, Wu D", "reference": { "type": "PubMed", "id": "11742004", "url": "https://pubmed.ncbi.nlm.nih.gov/11742004" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BQB4-1", "protein_name": "Sclerostin", "gene_name": "SOST", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96HF1-1", "protein_name": "Secreted frizzled-related protein 2", "gene_name": "SFRP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBU2-1", "protein_name": "Dickkopf-related protein 2", "gene_name": "DKK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94907-1", "protein_name": "Dickkopf-related protein 1", "gene_name": "DKK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MU8-1", "protein_name": "Kremen protein 1", "gene_name": "KREMEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N474-1", "protein_name": "Secreted frizzled-related protein 1", "gene_name": "SFRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75581-1", "protein_name": "Low-density lipoprotein receptor-related protein 6", "gene_name": "LRP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75197-1", "protein_name": "Low-density lipoprotein receptor-related protein 5", "gene_name": "LRP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56704-1", "protein_name": "Protein Wnt-3a", "gene_name": "WNT3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5W5-1", "protein_name": "Wnt inhibitory factor 1", "gene_name": "WIF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56705-1", "protein_name": "Protein Wnt-4", "gene_name": "WNT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41221-1", "protein_name": "Protein Wnt-5a", "gene_name": "WNT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14904-1", "protein_name": "Protein Wnt-9a", "gene_name": "WNT9A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBT3-1", "protein_name": "Dickkopf-related protein 4", "gene_name": "DKK4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NCW0", "url": "https://www.uniprot.org/uniprotkb/Q8NCW0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11742004", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 15 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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"count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins.", "journal": "Molecular and cellular biology", "date": "2002", "authors": "Brott BK, Sokol SY", "reference": { "type": "PubMed", "id": "12167704", "url": "https://pubmed.ncbi.nlm.nih.gov/12167704" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BQB4-1", "protein_name": "Sclerostin", "gene_name": "SOST", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96HF1-1", "protein_name": "Secreted frizzled-related protein 2", "gene_name": "SFRP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBU2-1", "protein_name": "Dickkopf-related protein 2", "gene_name": "DKK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94907-1", "protein_name": "Dickkopf-related protein 1", "gene_name": "DKK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MU8-1", "protein_name": "Kremen protein 1", "gene_name": "KREMEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N474-1", "protein_name": "Secreted frizzled-related protein 1", "gene_name": "SFRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75581-1", "protein_name": "Low-density lipoprotein receptor-related protein 6", "gene_name": "LRP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75197-1", "protein_name": "Low-density lipoprotein receptor-related protein 5", "gene_name": "LRP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56704-1", "protein_name": "Protein Wnt-3a", "gene_name": "WNT3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5W5-1", "protein_name": "Wnt inhibitory factor 1", "gene_name": "WIF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56705-1", "protein_name": "Protein Wnt-4", "gene_name": "WNT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41221-1", "protein_name": "Protein Wnt-5a", "gene_name": "WNT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14904-1", "protein_name": "Protein Wnt-9a", "gene_name": "WNT9A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBT3-1", "protein_name": "Dickkopf-related protein 4", "gene_name": "DKK4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NCW0", "url": "https://www.uniprot.org/uniprotkb/Q8NCW0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.12167704", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 15 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling.", "journal": "Gene", "date": "2003", "authors": "Mao B, Niehrs C", "reference": { "type": "PubMed", "id": "12527209", "url": "https://pubmed.ncbi.nlm.nih.gov/12527209" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BQB4-1", "protein_name": "Sclerostin", "gene_name": "SOST", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96HF1-1", "protein_name": "Secreted frizzled-related protein 2", "gene_name": "SFRP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBU2-1", "protein_name": "Dickkopf-related protein 2", "gene_name": "DKK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94907-1", "protein_name": "Dickkopf-related protein 1", "gene_name": "DKK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MU8-1", "protein_name": "Kremen protein 1", "gene_name": "KREMEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N474-1", "protein_name": "Secreted frizzled-related protein 1", "gene_name": "SFRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75581-1", "protein_name": "Low-density lipoprotein receptor-related protein 6", "gene_name": "LRP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75197-1", "protein_name": "Low-density lipoprotein receptor-related protein 5", "gene_name": "LRP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56704-1", "protein_name": "Protein Wnt-3a", "gene_name": "WNT3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5W5-1", "protein_name": "Wnt inhibitory factor 1", "gene_name": "WIF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56705-1", "protein_name": "Protein Wnt-4", "gene_name": "WNT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41221-1", "protein_name": "Protein Wnt-5a", "gene_name": "WNT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14904-1", "protein_name": "Protein Wnt-9a", "gene_name": "WNT9A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBT3-1", "protein_name": "Dickkopf-related protein 4", "gene_name": "DKK4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NCW0", "url": "https://www.uniprot.org/uniprotkb/Q8NCW0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.12527209", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": 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"protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BQB4-1", "protein_name": "Sclerostin", "gene_name": "SOST", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96HF1-1", "protein_name": "Secreted frizzled-related protein 2", "gene_name": "SFRP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBU2-1", "protein_name": "Dickkopf-related protein 2", "gene_name": "DKK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94907-1", "protein_name": "Dickkopf-related protein 1", "gene_name": "DKK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MU8-1", "protein_name": "Kremen protein 1", "gene_name": "KREMEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N474-1", "protein_name": "Secreted frizzled-related protein 1", "gene_name": "SFRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75581-1", "protein_name": "Low-density lipoprotein receptor-related protein 6", "gene_name": "LRP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75197-1", "protein_name": "Low-density lipoprotein receptor-related protein 5", "gene_name": "LRP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56704-1", "protein_name": "Protein Wnt-3a", "gene_name": "WNT3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5W5-1", "protein_name": "Wnt inhibitory factor 1", "gene_name": "WIF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56705-1", "protein_name": "Protein Wnt-4", "gene_name": "WNT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41221-1", "protein_name": "Protein Wnt-5a", "gene_name": "WNT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14904-1", "protein_name": "Protein Wnt-9a", "gene_name": "WNT9A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBT3-1", "protein_name": "Dickkopf-related protein 4", "gene_name": "DKK4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NCW0", "url": 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"sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Liu G, Bafico A, Harris VK, Aaronson SA", "reference": { "type": "PubMed", "id": "12897152", "url": "https://pubmed.ncbi.nlm.nih.gov/12897152" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BQB4-1", "protein_name": "Sclerostin", "gene_name": "SOST", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96HF1-1", "protein_name": "Secreted frizzled-related protein 2", "gene_name": "SFRP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBU2-1", "protein_name": "Dickkopf-related protein 2", "gene_name": "DKK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94907-1", "protein_name": "Dickkopf-related protein 1", "gene_name": "DKK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MU8-1", "protein_name": "Kremen protein 1", "gene_name": "KREMEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N474-1", "protein_name": "Secreted frizzled-related protein 1", "gene_name": "SFRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75581-1", "protein_name": "Low-density lipoprotein receptor-related protein 6", "gene_name": "LRP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75197-1", "protein_name": "Low-density lipoprotein receptor-related protein 5", "gene_name": "LRP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56704-1", "protein_name": "Protein Wnt-3a", "gene_name": "WNT3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5W5-1", "protein_name": "Wnt inhibitory factor 1", "gene_name": "WIF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56705-1", "protein_name": "Protein Wnt-4", "gene_name": "WNT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41221-1", "protein_name": "Protein Wnt-5a", "gene_name": "WNT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14904-1", "protein_name": "Protein Wnt-9a", "gene_name": "WNT9A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBT3-1", "protein_name": "Dickkopf-related protein 4", "gene_name": "DKK4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NCW0", "url": "https://www.uniprot.org/uniprotkb/Q8NCW0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.12897152", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 15 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ 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], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "SFRP1 regulates the growth of retinal ganglion cell axons through the Fz2 receptor.", "journal": "Nature neuroscience", "date": "2005", "authors": "Rodriguez J, Esteve P, Weinl C, Ruiz JM, Fermin Y, Trousse F, Dwivedy A, Holt C, Bovolenta P", "reference": { "type": "PubMed", "id": "16172602", "url": "https://pubmed.ncbi.nlm.nih.gov/16172602" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines.", "journal": "Biochemical and biophysical research communications", "date": "2006", "authors": "Lin YC, You L, Xu Z, He B, Mikami I, Thung E, Chou J, Kuchenbecker K, Kim J, Raz D, Yang CT, Chen JK, Jablons DM", "reference": { "type": "PubMed", "id": "16427602", "url": "https://pubmed.ncbi.nlm.nih.gov/16427602" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BQB4-1", "protein_name": "Sclerostin", "gene_name": "SOST", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96HF1-1", "protein_name": "Secreted frizzled-related protein 2", "gene_name": "SFRP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBU2-1", "protein_name": "Dickkopf-related protein 2", "gene_name": "DKK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94907-1", "protein_name": "Dickkopf-related protein 1", "gene_name": "DKK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MU8-1", "protein_name": 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"uniprot_canonical_ac": "O94907-1", "protein_name": "Dickkopf-related protein 1", "gene_name": "DKK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MU8-1", "protein_name": "Kremen protein 1", "gene_name": "KREMEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75197-1", "protein_name": "Low-density lipoprotein receptor-related protein 5", "gene_name": "LRP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBT3-1", "protein_name": "Dickkopf-related protein 4", "gene_name": "DKK4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NCW0", "url": "https://www.uniprot.org/uniprotkb/Q8NCW0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.17047023", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": 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0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Wnt3a binds to several sFRPs in the nanomolar range.", "journal": "Biochemical and biophysical research communications", "date": "2007", "authors": "Wawrzak D, Metioui M, Willems E, Hendrickx M, de Genst E, Leyns L", "reference": { "type": "PubMed", "id": "17462603", "url": "https://pubmed.ncbi.nlm.nih.gov/17462603" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BQB4-1", "protein_name": "Sclerostin", "gene_name": "SOST", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96HF1-1", "protein_name": "Secreted frizzled-related protein 2", "gene_name": "SFRP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBU2-1", "protein_name": "Dickkopf-related protein 2", "gene_name": "DKK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94907-1", "protein_name": "Dickkopf-related protein 1", "gene_name": "DKK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MU8-1", "protein_name": "Kremen protein 1", "gene_name": "KREMEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N474-1", "protein_name": "Secreted frizzled-related protein 1", "gene_name": "SFRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75581-1", "protein_name": "Low-density lipoprotein receptor-related protein 6", "gene_name": "LRP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75197-1", "protein_name": "Low-density lipoprotein receptor-related protein 5", "gene_name": "LRP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56704-1", "protein_name": "Protein Wnt-3a", "gene_name": "WNT3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5W5-1", "protein_name": "Wnt inhibitory factor 1", "gene_name": "WIF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56705-1", "protein_name": "Protein Wnt-4", "gene_name": "WNT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41221-1", "protein_name": "Protein Wnt-5a", "gene_name": "WNT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14904-1", "protein_name": "Protein Wnt-9a", "gene_name": "WNT9A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBT3-1", "protein_name": "Dickkopf-related protein 4", "gene_name": "DKK4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NCW0", "url": "https://www.uniprot.org/uniprotkb/Q8NCW0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.17462603", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 15 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling.", "journal": "PLoS medicine", "date": "2007", "authors": "Bjorklund P, Akerstrom G, Westin G", "reference": { "type": "PubMed", "id": "18044981", "url": "https://pubmed.ncbi.nlm.nih.gov/18044981" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBU2-1", "protein_name": "Dickkopf-related protein 2", "gene_name": "DKK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94907-1", "protein_name": "Dickkopf-related protein 1", "gene_name": "DKK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MU8-1", "protein_name": "Kremen protein 1", "gene_name": "KREMEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75197-1", "protein_name": "Low-density lipoprotein receptor-related protein 5", "gene_name": "LRP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBT3-1", "protein_name": "Dickkopf-related protein 4", "gene_name": "DKK4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NCW0", "url": "https://www.uniprot.org/uniprotkb/Q8NCW0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.18044981", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 6 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease.", "journal": "Journal of cell science", "date": "2008", "authors": "Bovolenta P, Esteve P, Ruiz JM, Cisneros E, Lopez-Rios J", "reference": { "type": "PubMed", "id": "18322270", "url": "https://pubmed.ncbi.nlm.nih.gov/18322270" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BQB4-1", "protein_name": "Sclerostin", "gene_name": "SOST", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96HF1-1", "protein_name": "Secreted frizzled-related protein 2", "gene_name": "SFRP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBU2-1", "protein_name": "Dickkopf-related protein 2", "gene_name": "DKK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94907-1", "protein_name": "Dickkopf-related protein 1", "gene_name": "DKK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MU8-1", "protein_name": "Kremen protein 1", "gene_name": "KREMEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N474-1", "protein_name": "Secreted frizzled-related protein 1", "gene_name": "SFRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75581-1", "protein_name": "Low-density lipoprotein receptor-related protein 6", "gene_name": "LRP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75197-1", "protein_name": "Low-density lipoprotein receptor-related protein 5", "gene_name": "LRP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56704-1", "protein_name": "Protein Wnt-3a", "gene_name": "WNT3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5W5-1", "protein_name": "Wnt inhibitory factor 1", "gene_name": "WIF1", "tax_name": 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Wang K, Zhang Y, Li X, Chen L, Wang H, Wu J, Zheng J, Wu D", "reference": { "type": "PubMed", "id": "18502762", "url": "https://pubmed.ncbi.nlm.nih.gov/18502762" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": 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"sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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a therapeutic target in breast cancer.", "journal": "PloS one", "date": "2009", "authors": "Bjorklund P, Svedlund J, Olsson AK, Akerstrom G, Westin G", "reference": { "type": "PubMed", "id": "19158955", "url": "https://pubmed.ncbi.nlm.nih.gov/19158955" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBU2-1", "protein_name": "Dickkopf-related protein 2", "gene_name": "DKK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94907-1", "protein_name": "Dickkopf-related protein 1", "gene_name": "DKK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MU8-1", "protein_name": "Kremen protein 1", "gene_name": "KREMEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75197-1", "protein_name": "Low-density lipoprotein receptor-related protein 5", "gene_name": "LRP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBT3-1", 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0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells.", "journal": "Molecular cancer therapeutics", "date": "2009", "authors": "Tang Y, Simoneau AR, Liao WX, Yi G, Hope C, Liu F, Li S, Xie J, Holcombe RF, Jurnak FA, Mercola D, Hoang BH, Zi X", "reference": { "type": "PubMed", "id": "19174556", "url": "https://pubmed.ncbi.nlm.nih.gov/19174556" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BQB4-1", "protein_name": "Sclerostin", "gene_name": "SOST", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96HF1-1", "protein_name": "Secreted frizzled-related protein 2", "gene_name": "SFRP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBU2-1", "protein_name": "Dickkopf-related protein 2", "gene_name": "DKK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94907-1", "protein_name": "Dickkopf-related protein 1", "gene_name": "DKK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MU8-1", "protein_name": "Kremen protein 1", "gene_name": "KREMEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N474-1", "protein_name": "Secreted frizzled-related protein 1", "gene_name": "SFRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75581-1", "protein_name": "Low-density lipoprotein receptor-related protein 6", "gene_name": "LRP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75197-1", "protein_name": "Low-density lipoprotein receptor-related protein 5", "gene_name": "LRP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56704-1", "protein_name": "Protein Wnt-3a", "gene_name": "WNT3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5W5-1", "protein_name": "Wnt inhibitory factor 1", "gene_name": "WIF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56705-1", "protein_name": "Protein Wnt-4", "gene_name": "WNT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41221-1", "protein_name": "Protein Wnt-5a", "gene_name": "WNT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14904-1", "protein_name": "Protein Wnt-9a", "gene_name": "WNT9A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBT3-1", "protein_name": "Dickkopf-related protein 4", "gene_name": "DKK4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NCW0", "url": "https://www.uniprot.org/uniprotkb/Q8NCW0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.19174556", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 15 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice.", "journal": "The Journal of clinical investigation", "date": "2009", "authors": "Kansara M, Tsang M, Kodjabachian L, Sims NA, Trivett MK, Ehrich M, Dobrovic A, Slavin J, Choong PF, Simmons PJ, Dawid IB, Thomas DM", "reference": { "type": "PubMed", "id": "19307728", "url": "https://pubmed.ncbi.nlm.nih.gov/19307728" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BQB4-1", "protein_name": "Sclerostin", "gene_name": "SOST", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96HF1-1", "protein_name": "Secreted frizzled-related protein 2", "gene_name": "SFRP2", 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"n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Bourhis E, Tam C, Franke Y, Bazan JF, Ernst J, Hwang J, Costa M, Cochran AG, Hannoush RN", "reference": { "type": "PubMed", "id": "20093360", "url": "https://pubmed.ncbi.nlm.nih.gov/20093360" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BQB4-1", "protein_name": "Sclerostin", "gene_name": "SOST", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96HF1-1", "protein_name": "Secreted frizzled-related protein 2", "gene_name": "SFRP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBU2-1", "protein_name": "Dickkopf-related protein 2", "gene_name": "DKK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94907-1", "protein_name": "Dickkopf-related protein 1", "gene_name": "DKK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MU8-1", "protein_name": "Kremen protein 1", "gene_name": "KREMEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14905-1", "protein_name": "Protein Wnt-9b", "gene_name": "WNT9B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N474-1", "protein_name": "Secreted frizzled-related protein 1", "gene_name": "SFRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75581-1", "protein_name": "Low-density lipoprotein receptor-related protein 6", "gene_name": "LRP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75197-1", "protein_name": "Low-density lipoprotein receptor-related protein 5", "gene_name": "LRP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56704-1", "protein_name": "Protein Wnt-3a", "gene_name": "WNT3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5W5-1", "protein_name": "Wnt inhibitory factor 1", "gene_name": "WIF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56705-1", "protein_name": "Protein Wnt-4", "gene_name": "WNT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41221-1", "protein_name": "Protein Wnt-5a", "gene_name": "WNT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14904-1", "protein_name": "Protein Wnt-9a", "gene_name": "WNT9A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBT3-1", "protein_name": "Dickkopf-related protein 4", "gene_name": "DKK4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NCW0", "url": "https://www.uniprot.org/uniprotkb/Q8NCW0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.20093360", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 16 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma.", "journal": "Molecular cancer", "date": "2010", "authors": "Dun X, Jiang H, Zou J, Shi J, Zhou L, Zhu R, Hou J", "reference": { "type": "PubMed", "id": "20846389", "url": "https://pubmed.ncbi.nlm.nih.gov/20846389" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NCW0", "url": "https://www.uniprot.org/uniprotkb/Q8NCW0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.20846389", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1.", "journal": "Nature structural & molecular biology", "date": "2011", "authors": "Malinauskas T, Aricescu AR, Lu W, Siebold C, Jones EY", "reference": { "type": "PubMed", "id": "21743455", "url": "https://pubmed.ncbi.nlm.nih.gov/21743455" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BQB4-1", "protein_name": "Sclerostin", "gene_name": "SOST", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96HF1-1", "protein_name": "Secreted frizzled-related protein 2", "gene_name": "SFRP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBU2-1", "protein_name": "Dickkopf-related protein 2", "gene_name": "DKK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94907-1", "protein_name": "Dickkopf-related protein 1", "gene_name": "DKK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MU8-1", "protein_name": "Kremen protein 1", "gene_name": "KREMEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N474-1", "protein_name": "Secreted frizzled-related protein 1", "gene_name": "SFRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75581-1", "protein_name": "Low-density lipoprotein receptor-related protein 6", "gene_name": "LRP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75197-1", "protein_name": "Low-density lipoprotein receptor-related protein 5", "gene_name": "LRP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56704-1", "protein_name": "Protein Wnt-3a", "gene_name": "WNT3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5W5-1", "protein_name": "Wnt inhibitory factor 1", "gene_name": "WIF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56705-1", "protein_name": "Protein Wnt-4", "gene_name": "WNT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41221-1", "protein_name": "Protein Wnt-5a", "gene_name": "WNT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14904-1", "protein_name": "Protein Wnt-9a", "gene_name": "WNT9A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBT3-1", "protein_name": "Dickkopf-related protein 4", "gene_name": "DKK4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NCW0", "url": "https://www.uniprot.org/uniprotkb/Q8NCW0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.21743455", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 15 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Wnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5/6.", "journal": "Structure (London, England : 1993)", "date": "2011", "authors": "Bourhis E, Wang W, Tam C, Hwang J, Zhang Y, Spittler D, Huang OW, Gong Y, Estevez A, Zilberleyb I, Rouge L, Chiu C, Wu Y, Costa M, Hannoush RN, Franke Y, Cochran AG", "reference": { "type": "PubMed", "id": "21944579", "url": "https://pubmed.ncbi.nlm.nih.gov/21944579" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BQB4-1", "protein_name": "Sclerostin", "gene_name": "SOST", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96HF1-1", "protein_name": "Secreted frizzled-related protein 2", "gene_name": "SFRP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBU2-1", "protein_name": "Dickkopf-related protein 2", "gene_name": "DKK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94907-1", "protein_name": "Dickkopf-related protein 1", "gene_name": "DKK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MU8-1", "protein_name": "Kremen protein 1", "gene_name": "KREMEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N474-1", "protein_name": "Secreted frizzled-related protein 1", "gene_name": "SFRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75581-1", "protein_name": "Low-density lipoprotein receptor-related protein 6", "gene_name": "LRP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75197-1", "protein_name": "Low-density lipoprotein receptor-related protein 5", "gene_name": "LRP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56704-1", "protein_name": "Protein Wnt-3a", "gene_name": "WNT3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5W5-1", "protein_name": "Wnt inhibitory factor 1", "gene_name": "WIF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56705-1", "protein_name": "Protein Wnt-4", "gene_name": "WNT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41221-1", "protein_name": "Protein Wnt-5a", "gene_name": "WNT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14904-1", "protein_name": "Protein Wnt-9a", "gene_name": "WNT9A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBT3-1", "protein_name": "Dickkopf-related protein 4", "gene_name": "DKK4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NCW0", "url": "https://www.uniprot.org/uniprotkb/Q8NCW0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.21944579", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 15 } ], 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Crystal structures of the extracellular domain of LRP6 and its complex with DKK1.", "journal": "Nature structural & molecular biology", "date": "2011", "authors": "Cheng Z, Biechele T, Wei Z, Morrone S, Moon RT, Wang L, Xu W", "reference": { "type": "PubMed", "id": "21984209", "url": "https://pubmed.ncbi.nlm.nih.gov/21984209" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 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ectodomain reveal a platform for Wnt signaling.", "journal": "Developmental cell", "date": "2011", "authors": "Chen S, Bubeck D, MacDonald BT, Liang WX, Mao JH, Malinauskas T, Llorca O, Aricescu AR, Siebold C, He X, Jones EY", "reference": { "type": "PubMed", "id": "22000855", "url": "https://pubmed.ncbi.nlm.nih.gov/22000855" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BQB4-1", "protein_name": "Sclerostin", "gene_name": "SOST", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96HF1-1", "protein_name": "Secreted frizzled-related protein 2", "gene_name": "SFRP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBU2-1", "protein_name": "Dickkopf-related protein 2", "gene_name": "DKK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94907-1", "protein_name": "Dickkopf-related protein 1", "gene_name": "DKK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MU8-1", "protein_name": "Kremen protein 1", "gene_name": "KREMEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N474-1", "protein_name": "Secreted frizzled-related protein 1", "gene_name": "SFRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75581-1", "protein_name": "Low-density lipoprotein receptor-related protein 6", "gene_name": "LRP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75197-1", "protein_name": "Low-density lipoprotein receptor-related protein 5", "gene_name": "LRP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56704-1", "protein_name": "Protein Wnt-3a", "gene_name": "WNT3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5W5-1", "protein_name": "Wnt inhibitory factor 1", "gene_name": "WIF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56705-1", "protein_name": "Protein Wnt-4", "gene_name": "WNT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41221-1", "protein_name": "Protein 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}, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The WIF domain of the human and Drosophila Wif-1 secreted factors confers specificity for Wnt or Hedgehog.", "journal": "Development (Cambridge, England)", "date": "2012", "authors": "Sanchez-Hernandez D, Sierra J, Ortigao-Farias JR, Guerrero I", "reference": { "type": "PubMed", "id": "22951645", "url": "https://pubmed.ncbi.nlm.nih.gov/22951645" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BQB4-1", "protein_name": "Sclerostin", "gene_name": "SOST", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96HF1-1", "protein_name": "Secreted frizzled-related protein 2", "gene_name": "SFRP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBU2-1", "protein_name": "Dickkopf-related protein 2", "gene_name": "DKK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94907-1", "protein_name": "Dickkopf-related protein 1", "gene_name": "DKK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MU8-1", "protein_name": "Kremen protein 1", "gene_name": "KREMEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N474-1", "protein_name": "Secreted frizzled-related protein 1", "gene_name": "SFRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75581-1", "protein_name": "Low-density lipoprotein receptor-related protein 6", "gene_name": "LRP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75197-1", "protein_name": "Low-density lipoprotein receptor-related protein 5", "gene_name": "LRP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56704-1", "protein_name": "Protein Wnt-3a", "gene_name": "WNT3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5W5-1", "protein_name": "Wnt inhibitory factor 1", "gene_name": "WIF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56705-1", "protein_name": "Protein Wnt-4", "gene_name": "WNT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41221-1", "protein_name": "Protein Wnt-5a", "gene_name": "WNT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14904-1", "protein_name": "Protein Wnt-9a", "gene_name": "WNT9A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBT3-1", "protein_name": "Dickkopf-related protein 4", "gene_name": "DKK4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NCW0", "url": "https://www.uniprot.org/uniprotkb/Q8NCW0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.22951645", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 15 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Characterization of a Wnt-binding site of the WIF-domain of Wnt inhibitory factor-1.", "journal": "FEBS letters", "date": "2012", "authors": "Banyai L, Kerekes K, Patthy L", "reference": { "type": "PubMed", "id": "22986341", "url": 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"o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Kremen1-induced cell death is regulated by homo- and heterodimerization.", "journal": "Cell death discovery", "date": "2019", "authors": "Sumia I, Pierani A, Causeret F", "reference": { "type": "PubMed", "id": "31069116", "url": "https://pubmed.ncbi.nlm.nih.gov/31069116" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NCW0-1", "protein_name": "Kremen protein 2", "gene_name": "KREMEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8K1S7-1", "protein_name": "Kremen protein 2", "gene_name": "Kremen2", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NCW0", "url": "https://www.uniprot.org/uniprotkb/Q8NCW0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.31069116", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": 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