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Biol. Chem.", "date": "2018", "authors": "Gonzalez-Serrano LE, Karim L, Pierre F, Schwenzer H, Rotig A, Munnich A, Sissler M", "reference": { "type": "PubMed", "id": "30006346", "url": "https://pubmed.ncbi.nlm.nih.gov/30006346" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9Y2Z4-1", "protein_name": "Tyrosine--tRNA ligase, mitochondrial", "gene_name": "YARS2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PI48-1", "protein_name": "Aspartate--tRNA ligase, mitochondrial", "gene_name": "DARS2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5T160-1", "protein_name": "Probable arginine--tRNA ligase, mitochondrial", "gene_name": "RARS2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9Y2Z4", "url": "https://www.uniprot.org/uniprotkb/Q9Y2Z4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 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"uniprot_canonical_ac": "Q5T160-1" }, { "start_pos": 530, "end_pos": 530, "sequence_org": "H", "sequence_mut": "Y", "comment": "No effect on mitochondrial membrane localization.", "evidence": [ { "database": "UniProtKB", "id": "Q5T160", "url": "https://www.uniprot.org/uniprotkb/Q5T160" }, { "database": "PubMed", "id": "30006346", "url": "https://pubmed.ncbi.nlm.nih.gov/30006346" } ], "uniprot_canonical_ac": "Q5T160-1" }, { "start_pos": 9, "end_pos": 9, "sequence_org": "I", "sequence_mut": "V", "comment": "No effect on mitochondrial membrane localization.", "evidence": [ { "database": "UniProtKB", "id": "Q5T160", "url": "https://www.uniprot.org/uniprotkb/Q5T160" }, { "database": "PubMed", "id": "30006346", "url": "https://pubmed.ncbi.nlm.nih.gov/30006346" } ], "uniprot_canonical_ac": "Q5T160-1" } ], "record_id": "pubmed.30006346", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Contribution of a mitochondrial tyrosyl-tRNA synthetase mutation to the phenotypic expression of the deafness-associated tRNA(Ser(UCN)) 7511A>G mutation.", "journal": "The Journal of biological chemistry", "date": "2019", "authors": "Fan W, Zheng J, Kong W, Cui L, Aishanjiang M, Yi Q, Wang M, Cang X, Tang X, Chen Y, Mo JQ, Sondheimer N, Ge W, Guan MX", "reference": { "type": "PubMed", "id": "31685661", "url": 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", 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"field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Nuclear modifier YARS2 allele correction restored retinal ganglion cells-specific deficiencies in Leber's hereditary optic neuropathy.", "journal": "Human molecular genetics", "date": "2023-01-05", "authors": "Chen Jia-Rong, Chen Chao, Chen Jie, Ji Yanchun, Lian Yanna, Zhang Juanjuan, Yu Jialing, Li Xiang-Yao, Qu Jia, Guan Min-Xin", "reference": { "type": "PubMed", "id": "36611011", "url": "https://pubmed.ncbi.nlm.nih.gov/36611011" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9Y2Z4-1", "protein_name": "Tyrosine--tRNA ligase, mitochondrial", "gene_name": "YARS2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9Y2Z4", "url": "https://www.uniprot.org/uniprotkb/Q9Y2Z4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.36611011", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ 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Struct. Biol.", "date": "2000", "authors": "Suto R K, Clarkson M J, Tremethick D J, Luger K", "reference": { "type": "PubMed", "id": "11101893", "url": "https://pubmed.ncbi.nlm.nih.gov/11101893" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P0C0S5-1", "protein_name": "Histone H2A.Z", "gene_name": "H2AZ1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62806-1", "protein_name": "Histone H4", "gene_name": "H4c11; H4c12; H4c14; H4c16; H4c1; H4c2; H4c3; H4c4; H4c6; H4c8; H4c9; Hist1h4m", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P0C0S5", "url": "https://www.uniprot.org/uniprotkb/P0C0S5" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11101893", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": 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}, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry.", "journal": "Molecular & cellular proteomics : MCP", "date": "2006", "authors": "Bonenfant D, Coulot M, Towbin H, 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"total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { 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Proteome Res.", "date": "2006", "authors": "Boyne MT 2nd, Pesavento JJ, Mizzen CA, Kelleher NL", "reference": { "type": "PubMed", "id": "16457589", "url": "https://pubmed.ncbi.nlm.nih.gov/16457589" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P0C0S5-1", "protein_name": "Histone H2A.Z", "gene_name": "H2AZ1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0C0S8-1", "protein_name": "Histone H2A type 1", "gene_name": "H2AC11; H2AC13; H2AC15; H2AC16; H2AC17", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93077-1", "protein_name": "Histone H2A type 1-C", "gene_name": "H2AC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q71UI9-1", "protein_name": "Histone H2A.V", "gene_name": "H2AZ2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04908-1", "protein_name": "Histone H2A type 1-B/E", "gene_name": "H2AC4; H2AC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20671-1", "protein_name": "Histone H2A type 1-D", "gene_name": "H2AC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16777-1", "protein_name": "Histone H2A type 2-C", "gene_name": "H2AC20", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6FI13-1", "protein_name": "Histone H2A type 2-A", "gene_name": "H2AC18; 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Sequence and regulation.", "journal": "J. Biol. Chem.", "date": "1990", "authors": "Hatch C L, Bonner W M", "reference": { "type": "PubMed", "id": "1697587", "url": "https://pubmed.ncbi.nlm.nih.gov/1697587" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P0C0S5-1", "protein_name": "Histone H2A.Z", "gene_name": "H2AZ1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P0C0S5", "url": "https://www.uniprot.org/uniprotkb/P0C0S5" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.1697587", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", 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"total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation.", "journal": "EMBO J.", "date": "2010", "authors": "Cuadrado A, Corrado N, Perdiguero E, Lafarga V, Munoz-Canoves P, Nebreda AR", "reference": { "type": "PubMed", "id": "20473270", "url": "https://pubmed.ncbi.nlm.nih.gov/20473270" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P0C0S5-1", "protein_name": "Histone H2A.Z", "gene_name": "H2AZ1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8R331-1", "protein_name": "Zinc finger HIT domain-containing protein 1", "gene_name": 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}, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Modification of histones by sugar beta-N-acetylglucosamine (GlcNAc) occurs on multiple residues, including histone H3 serine 10, and is cell cycle-regulated.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Zhang S, Roche K, Nasheuer HP, Lowndes NF", "reference": { "type": "PubMed", "id": "21896475", "url": "https://pubmed.ncbi.nlm.nih.gov/21896475" }, "referenced_glycans": [ { "glytoucan_ac": "G49108TO" } ], "referenced_proteins": [ { "uniprot_canonical_ac": "P0C0S5-1", "protein_name": "Histone H2A.Z", "gene_name": "H2AZ1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P84243-1", "protein_name": 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0 }, { "field": "o_linked_glycan_sites", "count": 18 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 10 }, { "field": "exact_o_linked_sites", "count": 10 }, { "field": "exact_o_linked_glycan_sites", "count": 10 }, { "field": "exact_o_linked_glycans", "count": 1 }, { "field": "fuzzy_sites", "count": 8 }, { "field": "fuzzy_o_linked_sites", "count": 8 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 8 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl", "filter_code", "uniprot_canonical_ac" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal.", "journal": "Epigenetics", "date": "2013", "authors": "Binda O, Sevilla A, LeRoy G, Lemischka IR, Garcia BA, Richard S", "reference": { "type": "PubMed", "id": "23324626", "url": "https://pubmed.ncbi.nlm.nih.gov/23324626" 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], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1.", "journal": "Nature structural & molecular biology", "date": "2016", "authors": "Latrick CM, Marek M, Ouararhni K, Papin C, Stoll I, Ignatyeva M, Obri A, Ennifar E, Dimitrov S, Romier C, Hamiche A", "reference": { "type": "PubMed", "id": "26974126", "url": "https://pubmed.ncbi.nlm.nih.gov/26974126" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P0C0S5-1", "protein_name": 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Abolishes interaction with H2AZ1 and H2BC11 and exchange of H2A for H2AZ1 in nucleosomes; when associated with A-29--37-A.", "evidence": [ { "database": "UniProtKB", "id": "Q15906", "url": "https://www.uniprot.org/uniprotkb/Q15906" }, { "database": "PubMed", "id": "26974126", "url": "https://pubmed.ncbi.nlm.nih.gov/26974126" } ], "uniprot_canonical_ac": "Q15906-1" } ], "record_id": "pubmed.26974126", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation.", "journal": "EMBO J.", "date": "2017", "authors": "Punzeler S, Link S, Wagner G, Keilhauer EC, Kronbeck N, Spitzer RM, Leidescher S, Markaki Y, Mentele E, Regnard C, Schneider K, Takahashi D, Kusakabe M, Vardabasso C, Zink LM, Straub T, Bernstein E, Harata M, Leonhardt H, Mann M, Rupp RA, Hake SB", "reference": { "type": "PubMed", "id": "28645917", "url": "https://pubmed.ncbi.nlm.nih.gov/28645917" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P0C0S5-1", "protein_name": "Histone H2A.Z", "gene_name": "H2AZ1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96N64-1", "protein_name": "PWWP domain-containing protein 2A", "gene_name": "PWWP2A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P0C0S5", "url": "https://www.uniprot.org/uniprotkb/P0C0S5" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.28645917", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 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"DNA repair complex licenses acetylation of H2A.Z.1 by KAT2A during transcription.", "journal": "Nature chemical biology", "date": "2019", "authors": "Semer M, Bidon B, Larnicol A, Caliskan G, Catez P, Egly JM, Coin F, Le May N", "reference": { "type": "PubMed", "id": "31527837", "url": "https://pubmed.ncbi.nlm.nih.gov/31527837" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P0C0S5-1", "protein_name": "Histone H2A.Z", "gene_name": "H2AZ1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01831-1", "protein_name": "DNA repair protein complementing XP-C cells", "gene_name": "XPC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92830-1", "protein_name": "Histone acetyltransferase KAT2A", "gene_name": "KAT2A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P0C0S5", "url": "https://www.uniprot.org/uniprotkb/P0C0S5" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 12, "end_pos": 14, "sequence_org": "KAK", "sequence_mut": "AAA", "comment": "Decreased acetylation by KAT2A.", "evidence": [ { "database": "UniProtKB", "id": "P0C0S5", "url": "https://www.uniprot.org/uniprotkb/P0C0S5" }, { "database": "PubMed", "id": "31527837", "url": "https://pubmed.ncbi.nlm.nih.gov/31527837" } ], "uniprot_canonical_ac": "P0C0S5-1" }, { "start_pos": 5, "end_pos": 14, "sequence_org": "KAGKDSGKAK", "sequence_mut": "AAGKDSGAAA", "comment": "Decreased acetylation by KAT2A.", "evidence": [ { "database": "UniProtKB", "id": "P0C0S5", "url": "https://www.uniprot.org/uniprotkb/P0C0S5" }, { "database": "PubMed", "id": "31527837", "url": "https://pubmed.ncbi.nlm.nih.gov/31527837" } ], "uniprot_canonical_ac": "P0C0S5-1" }, { "start_pos": 5, "end_pos": 8, "sequence_org": "KAGK", "sequence_mut": "AAGA", "comment": "Decreased acetylation by KAT2A.", "evidence": [ { "database": "UniProtKB", "id": 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"count": 0 } ], "sort_fields": [] } ] }, { "title": "Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2.", "journal": "Cell discovery", "date": "2021-12-28", "authors": "Delaney Kyle, Tan Minjia, Zhu Zhesi, Gao Jinjun, Dai Lunzhi, Kim Sunjoo, Ding Jun, He Maomao, Halabelian Levon, Yang Lu, Nagarajan Prabakaran, Parthun Mark Robert, Lee Sangkyu, Khochbin Saadi, Zheng Yujun George, Zhao Yingming", "reference": { "type": "PubMed", "id": "34961760", "url": "https://pubmed.ncbi.nlm.nih.gov/34961760" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P0C0S5-1", "protein_name": "Histone H2A.Z", "gene_name": "H2AZ1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P84243-1", "protein_name": "Histone H3.3", "gene_name": "H3-3A; H3-3B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10412-1", "protein_name": "Histone H1.4", "gene_name": "H1-4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0C0S8-1", "protein_name": "Histone H2A type 1", "gene_name": "H2AC11; H2AC13; H2AC15; H2AC16; H2AC17", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62805-1", "protein_name": "Histone H4", "gene_name": "H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9", "tax_name": "Human" }, { "uniprot_canonical_ac": "P68431-1", "protein_name": "Histone H3.1", "gene_name": "H3C10; H3C11; H3C12; H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16778-1", "protein_name": "Histone H2B type 2-E", "gene_name": "H2BC21", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62807-1", "protein_name": "Histone H2B type 1-C/E/F/G/I", "gene_name": "H2BC10; H2BC4; H2BC6; H2BC7; H2BC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14929-1", "protein_name": "Histone acetyltransferase type B catalytic subunit", "gene_name": "HAT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q71DI3-1", "protein_name": "Histone H3.2", "gene_name": "H3C13; H3C14; H3C15", "tax_name": "Human" }, { "uniprot_canonical_ac": "P16403-1", "protein_name": "Histone H1.2", "gene_name": "H1-2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6DRA6-1", "protein_name": "Putative histone H2B type 2-D", "gene_name": "H2BC19P", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5QNW6-1", "protein_name": "Histone H2B type 2-F", "gene_name": "H2BC18", "tax_name": "Human" }, { "uniprot_canonical_ac": "P33778-1", "protein_name": "Histone H2B type 1-B", "gene_name": "H2BC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58876-1", "protein_name": "Histone H2B type 1-D", "gene_name": "H2BC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P23527-1", "protein_name": "Histone H2B type 1-O", "gene_name": "H2BC17", "tax_name": "Human" }, { "uniprot_canonical_ac": "P16401-1", "protein_name": "Histone H1.5", "gene_name": "H1-5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02539-1", "protein_name": "Histone H1.1", "gene_name": "H1-1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60814-1", "protein_name": "Histone H2B type 1-K", "gene_name": "H2BC12", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93077-1", "protein_name": "Histone H2A type 1-C", "gene_name": "H2AC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93079-1", "protein_name": "Histone H2B type 1-H", "gene_name": "H2BC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96KK5-1", "protein_name": "Histone H2A type 1-H", "gene_name": "H2AC12", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99879-1", "protein_name": "Histone H2B type 1-M", "gene_name": "H2BC14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IXJ6-1", "protein_name": "NAD-dependent protein deacetylase sirtuin-2", "gene_name": "SIRT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04908-1", "protein_name": "Histone H2A type 1-B/E", "gene_name": "H2AC4; H2AC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06899-1", "protein_name": "Histone H2B type 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Yongjun", "reference": { "type": "PubMed", "id": "36368958", "url": "https://pubmed.ncbi.nlm.nih.gov/36368958" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P0C0S5-1", "protein_name": "Histone H2A.Z", "gene_name": "H2AZ1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P0C0S5", "url": "https://www.uniprot.org/uniprotkb/P0C0S5" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.36368958", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { 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[] } ] }, { "title": "MicroRNA-455-3p accelerate malignant progression of tumor by targeting H2AFZ in colorectal cancer.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2022-12-08", "authors": "Ye Lizhen, Fan Tingting, Qin Ying, Qiu Cheng, Li Lulu, Dai Mengmeng, Zhou Yaoyao, Chen Yan, Jiang Yuyang", "reference": { "type": "PubMed", "id": "36482739", "url": "https://pubmed.ncbi.nlm.nih.gov/36482739" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P0C0S5-1", "protein_name": "Histone H2A.Z", "gene_name": "H2AZ1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P0C0S5", "url": "https://www.uniprot.org/uniprotkb/P0C0S5" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.36482739", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ 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Thromb.", "date": "2000", "authors": "Takabe W, Mataki C, Wada Y, Ishii M, Izumi A, Aburatani H, Hamakubo T, Niki E, Kodama T, Noguchi N", "reference": { "type": "PubMed", "id": "11521686", "url": "https://pubmed.ncbi.nlm.nih.gov/11521686" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P25789-1", "protein_name": "Proteasome subunit alpha type-4", "gene_name": "PSMA4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P25788-1", "protein_name": "Proteasome subunit alpha type-3", "gene_name": "PSMA3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P25787-1", "protein_name": "Proteasome subunit alpha type-2", "gene_name": "PSMA2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P25789", "url": "https://www.uniprot.org/uniprotkb/P25789" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11521686", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes).", "journal": "Biochim. 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Acta", "date": "1991", "authors": "Tamura T, Lee DH, Osaka F, Fujiwara T, Shin S, Chung CH, Tanaka K, Ichihara A", "reference": { "type": "PubMed", "id": "2025653", "url": "https://pubmed.ncbi.nlm.nih.gov/2025653" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P25789-1", "protein_name": "Proteasome subunit alpha type-4", "gene_name": "PSMA4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20618-1", "protein_name": "Proteasome subunit beta type-1", "gene_name": "PSMB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P25786-1", "protein_name": "Proteasome subunit alpha type-1", "gene_name": "PSMA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P25788-1", "protein_name": "Proteasome subunit alpha type-3", "gene_name": "PSMA3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P25787-1", "protein_name": "Proteasome subunit alpha type-2", "gene_name": "PSMA2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, 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"Potentially functional genetic variants of VAV2 and PSMA4 in the immune-activation pathway and non-small cell lung cancer survival.", "journal": "The journal of gene medicine", "date": "2022-10", "authors": "Bai Yushun, Zheng Ji, Cheng Lei, Liu Qi, Zhao Genming, Li Jingrao, Gu Yanzi, Xu Wanghong, Wang Mengyun, Wei Qingyi, Zhang Ruoxin", "reference": { "type": "PubMed", "id": "36039727", "url": "https://pubmed.ncbi.nlm.nih.gov/36039727" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P25789-1", "protein_name": "Proteasome subunit alpha type-4", "gene_name": "PSMA4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P52735-1", "protein_name": "Guanine nucleotide exchange factor VAV2", "gene_name": "VAV2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P25789", "url": "https://www.uniprot.org/uniprotkb/P25789" } ], "common_name": "Human", "glygen_name": "Human", 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A mammalian enzyme that hydrolyzes phytoceramide.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Mao C, Xu R, Szulc ZM, Bielawska A, Galadari SH, Obeid LM", "reference": { "type": "PubMed", "id": "11356846", "url": "https://pubmed.ncbi.nlm.nih.gov/11356846" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43688-1", "protein_name": "Phospholipid phosphatase 2", "gene_name": "PLPP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95470-1", "protein_name": "Sphingosine-1-phosphate lyase 1", "gene_name": "SGPL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BX95-1", "protein_name": "Sphingosine-1-phosphate phosphatase 1", "gene_name": "SGPP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IWX5-1", "protein_name": "Sphingosine-1-phosphate phosphatase 2", "gene_name": "SGPP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P48448-1", "protein_name": "Aldehyde dehydrogenase family 3 member B2", "gene_name": 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide.", "journal": "Molecular and cellular biology", "date": "2006", "authors": "Giussani P, Maceyka M, Le Stunff H, Mikami A, Lepine S, Wang E, Kelly S, Merrill AH Jr, Milstien S, Spiegel S", "reference": { "type": "PubMed", "id": "16782891", "url": "https://pubmed.ncbi.nlm.nih.gov/16782891" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43688-1", "protein_name": "Phospholipid phosphatase 2", "gene_name": "PLPP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95470-1", "protein_name": "Sphingosine-1-phosphate lyase 1", "gene_name": "SGPL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BX95-1", "protein_name": "Sphingosine-1-phosphate phosphatase 1", "gene_name": "SGPP1", "tax_name": "Human" }, { 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"count": 12 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { 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J.", "date": "2008", "authors": "Long JS, Pyne NJ, Pyne S", "reference": { "type": "PubMed", "id": "18215144", "url": "https://pubmed.ncbi.nlm.nih.gov/18215144" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43688-1", "protein_name": "Phospholipid phosphatase 2", "gene_name": "PLPP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14495-1", "protein_name": "Phospholipid phosphatase 3", "gene_name": "PLPP3", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43688", "url": "https://www.uniprot.org/uniprotkb/O43688" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.18215144", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": 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No effect on the ceramidase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q5QJU3", "url": "https://www.uniprot.org/uniprotkb/Q5QJU3" }, { "database": "PubMed", "id": "20089856", "url": "https://pubmed.ncbi.nlm.nih.gov/20089856" } ], "uniprot_canonical_ac": "Q5QJU3-1" } ], "record_id": "pubmed.20089856", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 11 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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"count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Molecular characterization, expression analysis, and role of ALDH3B1 in the cellular protection against oxidative stress.", "journal": "Free radical biology & medicine", "date": "2010", "authors": "Marchitti SA, Brocker C, Orlicky DJ, Vasiliou V", "reference": { "type": "PubMed", "id": "20699116", "url": "https://pubmed.ncbi.nlm.nih.gov/20699116" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43688-1", "protein_name": "Phospholipid phosphatase 2", "gene_name": "PLPP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95470-1", "protein_name": "Sphingosine-1-phosphate lyase 1", "gene_name": "SGPL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BX95-1", "protein_name": "Sphingosine-1-phosphate phosphatase 1", "gene_name": "SGPP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IWX5-1", "protein_name": "Sphingosine-1-phosphate phosphatase 2", "gene_name": "SGPP2", 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"evidence": [ { "database": "UniProtKB", "id": "O43688", "url": "https://www.uniprot.org/uniprotkb/O43688" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.20699116", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 11 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 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mammalian skin homeostasis and regulating whole-body energy expenditure.", "journal": "The Journal of pathology", "date": "2016-07", "authors": "Liakath-Ali Kifayathullah, Vancollie Valerie E, Lelliott Christopher J, Speak Anneliese O, Lafont David, Protheroe Hayley J, Ingvorsen Camilla, Galli Antonella, Green Angela, Gleeson Diane, Ryder Ed, Glover Leanne, Vizcay-Barrena Gema, Karp Natasha A, Arends Mark J, Brenn Thomas, Spiegel Sarah, Adams David J, Watt Fiona M, van der Weyden Louise", "reference": { "type": "PubMed", "id": "27126290", "url": "https://pubmed.ncbi.nlm.nih.gov/27126290" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43688-1", "protein_name": "Phospholipid phosphatase 2", "gene_name": "PLPP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95470-1", "protein_name": "Sphingosine-1-phosphate lyase 1", "gene_name": "SGPL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BX95-1", "protein_name": "Sphingosine-1-phosphate 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"o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells.", "journal": "DNA Cell Biol.", "date": "1998", "authors": "Leung DW, Tompkins CK, White T", "reference": { "type": "PubMed", "id": "9570154", "url": "https://pubmed.ncbi.nlm.nih.gov/9570154" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43688-1", "protein_name": "Phospholipid phosphatase 2", "gene_name": "PLPP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14494-1", "protein_name": "Phospholipid phosphatase 1", "gene_name": "PLPP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43688", "url": "https://www.uniprot.org/uniprotkb/O43688" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9570154", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Identification of a novel human phosphatidic acid phosphatase type 2 isoform.", "journal": "FEBS letters", "date": "1998", "authors": "Hooks SB, Ragan SP, Lynch KR", "reference": { "type": "PubMed", "id": "9607309", "url": "https://pubmed.ncbi.nlm.nih.gov/9607309" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43688-1", "protein_name": "Phospholipid phosphatase 2", "gene_name": "PLPP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14495-1", "protein_name": "Phospholipid phosphatase 3", "gene_name": "PLPP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14494-1", "protein_name": "Phospholipid phosphatase 1", "gene_name": "PLPP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43688", "url": "https://www.uniprot.org/uniprotkb/O43688" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9607309", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Roberts R, Sciorra VA, Morris AJ", "reference": { "type": "PubMed", "id": "9705349", "url": "https://pubmed.ncbi.nlm.nih.gov/9705349" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43688-1", "protein_name": "Phospholipid phosphatase 2", "gene_name": "PLPP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95470-1", "protein_name": "Sphingosine-1-phosphate lyase 1", "gene_name": "SGPL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BX95-1", "protein_name": "Sphingosine-1-phosphate phosphatase 1", "gene_name": "SGPP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IWX5-1", "protein_name": "Sphingosine-1-phosphate phosphatase 2", "gene_name": "SGPP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P48448-1", "protein_name": "Aldehyde dehydrogenase family 3 member B2", "gene_name": "ALDH3B2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P43353-1", "protein_name": "Aldehyde dehydrogenase family 3 member B1", "gene_name": "ALDH3B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14495-1", "protein_name": "Phospholipid phosphatase 3", "gene_name": "PLPP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14494-1", "protein_name": "Phospholipid phosphatase 1", "gene_name": "PLPP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TDN7-1", "protein_name": "Alkaline ceramidase 1", "gene_name": "ACER1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NUN7-1", "protein_name": "Alkaline ceramidase 3", "gene_name": "ACER3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5QJU3-1", "protein_name": "Alkaline ceramidase 2", "gene_name": "ACER2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43688", "url": "https://www.uniprot.org/uniprotkb/O43688" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 184, "end_pos": 184, "sequence_org": "D", "sequence_mut": "E", "comment": "Loss of binding to integrin. Loss of function in integrin-mediated cell-cell interaction.", "evidence": [ { "database": "UniProtKB", "id": "O14495", "url": "https://www.uniprot.org/uniprotkb/O14495" }, { "database": "PubMed", "id": "9705349", "url": "https://pubmed.ncbi.nlm.nih.gov/9705349" } ], "uniprot_canonical_ac": "O14495-1" } ], "record_id": "pubmed.9705349", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 11 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { 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"n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions.", "journal": "Nature", "date": "2015-02-26", "authors": "Liu Nian, Dai Qing, Zheng Guanqun, He Chuan, Parisien Marc, Pan Tao", "reference": { "type": "PubMed", "id": "25719671", "url": "https://pubmed.ncbi.nlm.nih.gov/25719671" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9HCE5-1", "protein_name": "N(6)-adenosine-methyltransferase non-catalytic subunit METTL14", "gene_name": "METTL14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86U44-1", "protein_name": "N(6)-adenosine-methyltransferase catalytic subunit METTL3", "gene_name": "METTL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07910-1", "protein_name": "Heterogeneous nuclear ribonucleoproteins C1/C2", "gene_name": "HNRNPC", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9HCE5", "url": "https://www.uniprot.org/uniprotkb/Q9HCE5" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.25719671", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex.", "journal": "Nature", "date": "2016", "authors": "Wang X, Feng J, Xue Y, Guan Z, Zhang D, Liu Z, Gong Z, Wang Q, Huang J, Tang C, Zou T, Yin P", "reference": { "type": "PubMed", "id": "27281194", "url": "https://pubmed.ncbi.nlm.nih.gov/27281194" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9HCE5-1", "protein_name": "N(6)-adenosine-methyltransferase non-catalytic subunit METTL14", "gene_name": "METTL14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86U44-1", "protein_name": "N(6)-adenosine-methyltransferase catalytic subunit METTL3", "gene_name": "METTL3", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9HCE5", "url": "https://www.uniprot.org/uniprotkb/Q9HCE5" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { 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Little or no effect on S-adenosyl-L-methionine-binding or methyltransferase activity; when associated with A-173.", "evidence": [ { "database": "UniProtKB", "id": "Q9HCE5", "url": "https://www.uniprot.org/uniprotkb/Q9HCE5" }, { "database": "PubMed", "id": "27373337", "url": "https://pubmed.ncbi.nlm.nih.gov/27373337" }, { "database": "PubMed", "id": "27281194", "url": "https://pubmed.ncbi.nlm.nih.gov/27281194" }, { "database": "PubMed", "id": "27627798", "url": "https://pubmed.ncbi.nlm.nih.gov/27627798" } ], "uniprot_canonical_ac": "Q9HCE5-1" }, { "start_pos": 245, "end_pos": 245, "sequence_org": "R", "sequence_mut": "E", "comment": "Reduced RNA-binding. 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Strong reduction in methyltransferase activity; when associated with A-550.", "evidence": [ { "database": "UniProtKB", "id": "Q86U44", "url": "https://www.uniprot.org/uniprotkb/Q86U44" }, { "database": "PubMed", "id": "27281194", "url": "https://pubmed.ncbi.nlm.nih.gov/27281194" }, { "database": "PubMed", "id": "27627798", "url": "https://pubmed.ncbi.nlm.nih.gov/27627798" } ], "uniprot_canonical_ac": "Q86U44-1" }, { "start_pos": 550, "end_pos": 550, "sequence_org": "Q", "sequence_mut": "A", "comment": "Slight reduction in methyltransferase activity. Strong reduction in methyltransferase activity; when associated with A-549.", "evidence": [ { "database": "UniProtKB", "id": "Q86U44", "url": "https://www.uniprot.org/uniprotkb/Q86U44" }, { "database": "PubMed", "id": "27281194", "url": "https://pubmed.ncbi.nlm.nih.gov/27281194" }, { "database": "PubMed", "id": "27627798", "url": "https://pubmed.ncbi.nlm.nih.gov/27627798" } ], "uniprot_canonical_ac": "Q86U44-1" } ], "phosphorylation": [ { "start_pos": 399, "end_pos": 399, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9HCE5", "url": "https://www.uniprot.org/uniprotkb/Q9HCE5" }, { "database": "PubMed", "id": "27281194", "url": "https://pubmed.ncbi.nlm.nih.gov/27281194" }, { "database": "PubMed", "id": "24275569", "url": "https://pubmed.ncbi.nlm.nih.gov/24275569" }, { "database": "PubMed", "id": "29348140", "url": "https://pubmed.ncbi.nlm.nih.gov/29348140" }, { "database": 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"count": 0 } ], "sort_fields": [] } ] }, { "title": "Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.", "journal": "Molecular cell", "date": "2016", "authors": "Wang P, Doxtader KA, Nam Y", "reference": { "type": "PubMed", "id": "27373337", "url": "https://pubmed.ncbi.nlm.nih.gov/27373337" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9HCE5-1", "protein_name": "N(6)-adenosine-methyltransferase non-catalytic subunit METTL14", "gene_name": "METTL14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N3J2-1", "protein_name": "N(6)-adenine-specific methyltransferase METTL4", "gene_name": "METTL4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86U44-1", "protein_name": "N(6)-adenosine-methyltransferase catalytic subunit METTL3", "gene_name": "METTL3", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9HCE5", "url": 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Little or no effect on S-adenosyl-L-methionine-binding or methyltransferase activity; when associated with A-173.", "evidence": [ { "database": "UniProtKB", "id": "Q9HCE5", "url": "https://www.uniprot.org/uniprotkb/Q9HCE5" }, { "database": "PubMed", "id": "27373337", "url": "https://pubmed.ncbi.nlm.nih.gov/27373337" }, { "database": "PubMed", "id": "27281194", "url": "https://pubmed.ncbi.nlm.nih.gov/27281194" }, { "database": "PubMed", "id": "27627798", "url": "https://pubmed.ncbi.nlm.nih.gov/27627798" } ], "uniprot_canonical_ac": "Q9HCE5-1" }, { "start_pos": 198, "end_pos": 198, "sequence_org": "Y", "sequence_mut": "A", "comment": "Does not affect methyltransferase activity of the heterodimer complex formed with METTL3.", "evidence": [ { "database": "UniProtKB", "id": "Q9HCE5", "url": "https://www.uniprot.org/uniprotkb/Q9HCE5" }, { "database": "PubMed", "id": "27627798", "url": "https://pubmed.ncbi.nlm.nih.gov/27627798" } ], "uniprot_canonical_ac": "Q9HCE5-1" }, { "start_pos": 254, "end_pos": 255, "sequence_org": "RR", "sequence_mut": "AA", "comment": "Strongly reduced methyltransferase activity of the heterodimer complex formed with METTL3.", "evidence": [ { "database": "UniProtKB", "id": "Q9HCE5", "url": "https://www.uniprot.org/uniprotkb/Q9HCE5" }, { "database": "PubMed", "id": "27627798", "url": "https://pubmed.ncbi.nlm.nih.gov/27627798" } ], "uniprot_canonical_ac": "Q9HCE5-1" }, { "start_pos": 338, "end_pos": 338, "sequence_org": "C", "sequence_mut": "A", "comment": "Does not affect methyltransferase activity of the heterodimer complex formed with METTL3.", "evidence": [ { "database": "UniProtKB", "id": "Q9HCE5", "url": "https://www.uniprot.org/uniprotkb/Q9HCE5" }, { "database": "PubMed", "id": "27627798", "url": "https://pubmed.ncbi.nlm.nih.gov/27627798" } ], "uniprot_canonical_ac": "Q9HCE5-1" }, { "start_pos": 362, "end_pos": 363, "sequence_org": "PT", "sequence_mut": "AA", "comment": "Little or no effect on methyltransferase activity of the heterodimer complex formed with METTL3.", "evidence": [ { "database": "UniProtKB", "id": "Q9HCE5", "url": "https://www.uniprot.org/uniprotkb/Q9HCE5" }, { "database": "PubMed", "id": "27627798", "url": "https://pubmed.ncbi.nlm.nih.gov/27627798" } ], "uniprot_canonical_ac": "Q9HCE5-1" }, { "start_pos": 395, "end_pos": 398, "sequence_org": "DPPW", "sequence_mut": "APPA", "comment": "Loss of function. Abolishes ability to regulate primary miRNA processing. Does not affect ability to promote mRNA translation. 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Strong reduction in methyltransferase activity; when associated with A-550.", "evidence": [ { "database": "UniProtKB", "id": "Q86U44", "url": "https://www.uniprot.org/uniprotkb/Q86U44" }, { "database": "PubMed", "id": "27281194", "url": "https://pubmed.ncbi.nlm.nih.gov/27281194" }, { "database": "PubMed", "id": "27627798", "url": "https://pubmed.ncbi.nlm.nih.gov/27627798" } ], "uniprot_canonical_ac": "Q86U44-1" }, { "start_pos": 550, "end_pos": 550, "sequence_org": "Q", "sequence_mut": "A", "comment": "Slight reduction in methyltransferase activity. 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lncRNA-FAS-AS1 promotes osteoarthritis progression by up-regulating ADAM8.", "journal": "International journal of rheumatic diseases", "date": "2024-09", "authors": "Zhang Zhehua, Mao Honggang, Li Fang, Wang Dahai, Liu Yan", "reference": { "type": "PubMed", "id": "39221886", "url": "https://pubmed.ncbi.nlm.nih.gov/39221886" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9HCE5-1", "protein_name": "N(6)-adenosine-methyltransferase non-catalytic subunit METTL14", "gene_name": "METTL14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q05910-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 8", "gene_name": "Adam8", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "P78325-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 8", "gene_name": "ADAM8", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9HCE5", "url": 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adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation.", "journal": "Oncogene", "date": "1999", "authors": "Garcia-Guzman M, Dolfi F, Zeh K, Vuori K", "reference": { "type": "PubMed", "id": "10618718", "url": "https://pubmed.ncbi.nlm.nih.gov/10618718" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P61224-1", "protein_name": "Ras-related protein Rap-1b", "gene_name": "RAP1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62834-1", "protein_name": "Ras-related protein Rap-1A", "gene_name": "RAP1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96N67-1", "protein_name": "Dedicator of cytokinesis protein 7", "gene_name": "DOCK7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13905-1", "protein_name": "Rap guanine nucleotide exchange factor 1", "gene_name": "RAPGEF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46109-1", "protein_name": "Crk-like protein", "gene_name": "CRKL", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63000-1", "protein_name": "Ras-related C3 botulinum toxin substrate 1", "gene_name": "RAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14210-1", "protein_name": "Hepatocyte growth factor", "gene_name": "HGF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13480-1", "protein_name": "GRB2-associated-binding protein 1", "gene_name": "GAB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08581-1", "protein_name": "Hepatocyte growth factor receptor", "gene_name": "MET", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46108-1", "protein_name": "Adapter molecule crk", "gene_name": "CRK", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P61224", "url": "https://www.uniprot.org/uniprotkb/P61224" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10618718", "abstract": "", "glycosylation": [], 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"o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Sakkab D, Lewitzky M, Posern G, Schaeper U, Sachs M, 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"gene_name": "MET", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46108-1", "protein_name": "Adapter molecule crk", "gene_name": "CRK", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P61224", "url": "https://www.uniprot.org/uniprotkb/P61224" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "phosphorylation": [ { "start_pos": 307, "end_pos": 307, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q13480", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q13480" }, { "database": "PubMed", "id": "16849525", "url": "https://pubmed.ncbi.nlm.nih.gov/16849525" }, { "database": "PubMed", "id": "19350053", "url": "https://pubmed.ncbi.nlm.nih.gov/19350053" }, { "database": "PubMed", "id": "24662916", "url": "https://pubmed.ncbi.nlm.nih.gov/24662916" }, { 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Commun.", "date": "1990", "authors": "Siess W, Winegar DA, Lapetina EG", "reference": { "type": "PubMed", "id": "1696481", "url": "https://pubmed.ncbi.nlm.nih.gov/1696481" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P61224-1", "protein_name": "Ras-related protein Rap-1b", "gene_name": "RAP1B", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P61224", "url": "https://www.uniprot.org/uniprotkb/P61224" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.1696481", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Phosphorylation-induced conformational changes in Rap1b: allosteric effects on switch domains and effector loop.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Edreira MM, Li S, Hochbaum D, Wong S, Gorfe AA, Ribeiro-Neto F, Woods VL Jr, Altschuler DL", "reference": { "type": "PubMed", "id": "19651783", "url": "https://pubmed.ncbi.nlm.nih.gov/19651783" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P61224-1", "protein_name": "Ras-related protein Rap-1b", "gene_name": "RAP1B", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P61224", "url": "https://www.uniprot.org/uniprotkb/P61224" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "phosphorylation": [ { "start_pos": 179, "end_pos": 179, "kinase_uniprot_canonical_ac": "P17612-1", "kinase_gene_name": "PRKACA", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P61224", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P61224" }, { "database": "PubMed", "id": "12089143", "url": "https://pubmed.ncbi.nlm.nih.gov/12089143" }, { "database": "PubMed", "id": "19651783", "url": "https://pubmed.ncbi.nlm.nih.gov/19651783" } ], "site_lbl": "Ser179", "uniprot_canonical_ac": "P61224-1" }, { "start_pos": 179, "end_pos": 179, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; 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