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        "title": "Isoforms of mammalian ubiquitin-activating enzyme.",
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        "title": "Protein ubiquitination is modulated by O-GlcNAc glycosylation.",
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        "title": "Expression, purification, and crystal structure of N-terminal domains of human ubiquitin-activating enzyme (E1).",
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                                "description": "A rare form of spinal muscular atrophy characterized by the neonatal onset of severe hypotonia, areflexia, profound weakness, multiple congenital contractures, facial dysmorphic features (myopathic face with open, tent-shaped mouth), cryptorchidism, and mild skeletal abnormalities (i.e. kyphosis, scoliosis), that is often preceded by polyhydramnios and reduced fetal movements in utero and followed by bone fractures shortly after birth. SMAX2 patients often have a limited life span, often succumbing to the disease within 2 years, as muscle weakness is progressive and chest muscle involvement eventually leads to ventilatory insufficiency and respiratory failure."
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                            {
                                "id": "MONDO:0010532",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0010532",
                                "name": "X-linked distal arthrogryposis multiplex congenita",
                                "description": ""
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                            {
                                "id": "MONDO:0010532",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0010532",
                                "name": "X-linked spinal muscular atrophy type 2",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0010532",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0010532",
                                "name": "spinal muscular atrophy with arthrogryposis",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0010532",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0010532",
                                "name": "spinal muscular atrophy, X-linked 2, infantile, X-linked recessive",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0010532",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0010532",
                                "name": "spinal muscular atrophy, X-linked type 2",
                                "description": ""
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                            {
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    {
        "title": "Translation of cytoplasmic UBA1 contributes to VEXAS syndrome pathogenesis.",
        "journal": "Blood",
        "date": "2022-09-29",
        "authors": "Ferrada Marcela A, Savic Sinisa, Cardona Daniela Ospina, Collins Jason C, Alessi Hugh, Gutierrez-Rodrigues Fernanda, Kumar Dinesh Babu Uthaya, Wilson Lorena, Goodspeed Wendy, Topilow James S, Paik Julie J, Poulter James A, Kermani Tanaz A, Koster Matthew J, Warrington Kenneth J, Cargo Catherine, Tattersall Rachel S, Duncan Christopher J A, Cantor Anna, Hoffmann Patrycja, Payne Elspeth M, Bonnekoh Hanna, Krause Karoline, Cowen Edward W, Calvo Katherine R, Patel Bhavisha A, Ombrello Amanda K, Kastner Daniel L, Young Neal S, Werner Achim, Grayson Peter C, Beck David B",
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                "alt_nt": "null",
                "minor_allelic_frequency": "",
                "site_lbl": "M41",
                "disease": [
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                        "recommended_name": {
                            "id": "DOID:0111827",
                            "resource": "Disease Ontology",
                            "url": "https://disease-ontology.org/term/DOID:0111827",
                            "name": "X-linked spinal muscular atrophy 2",
                            "description": "A spinal muscular atrophy characterized by neonatal onset of severe hypotonia, areflexia, and multiple congenital contractures associated with loss of anterior horn cells and infantile death that has_material_basis_in hemizygous mutation in the UBA1 gene on chromosome Xp11.3."
                        },
                        "synonyms": [
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                                "resource": "Disease Ontology",
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                                "name": "SMAX2",
                                "description": ""
                            },
                            {
                                "id": "DOID:0111827",
                                "resource": "Disease Ontology",
                                "url": "https://disease-ontology.org/term/DOID:0111827",
                                "name": "X-linked distal arthrogryposis multiplex congenita",
                                "description": ""
                            },
                            {
                                "id": "DOID:0111827",
                                "resource": "Disease Ontology",
                                "url": "https://disease-ontology.org/term/DOID:0111827",
                                "name": "X-linked spinal muscular atrophy type 2",
                                "description": ""
                            },
                            {
                                "id": "DOID:0111827",
                                "resource": "Disease Ontology",
                                "url": "https://disease-ontology.org/term/DOID:0111827",
                                "name": "infantile-onset X-linked spinal muscular atrophy",
                                "description": ""
                            },
                            {
                                "id": "DOID:0111827",
                                "resource": "Disease Ontology",
                                "url": "https://disease-ontology.org/term/DOID:0111827",
                                "name": "spinal muscular atrophy with arthrogryposis",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0010532",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0010532",
                                "name": "infantile-onset X-linked spinal muscular atrophy",
                                "description": "A rare form of spinal muscular atrophy characterized by the neonatal onset of severe hypotonia, areflexia, profound weakness, multiple congenital contractures, facial dysmorphic features (myopathic face with open, tent-shaped mouth), cryptorchidism, and mild skeletal abnormalities (i.e. kyphosis, scoliosis), that is often preceded by polyhydramnios and reduced fetal movements in utero and followed by bone fractures shortly after birth. SMAX2 patients often have a limited life span, often succumbing to the disease within 2 years, as muscle weakness is progressive and chest muscle involvement eventually leads to ventilatory insufficiency and respiratory failure."
                            },
                            {
                                "id": "MONDO:0010532",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0010532",
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                            },
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                                "name": "X-linked distal arthrogryposis multiplex congenita",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0010532",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0010532",
                                "name": "X-linked spinal muscular atrophy type 2",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0010532",
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                                "url": "https://monarchinitiative.org/disease/MONDO:0010532",
                                "name": "spinal muscular atrophy with arthrogryposis",
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                            },
                            {
                                "id": "MONDO:0010532",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0010532",
                                "name": "spinal muscular atrophy, X-linked 2, infantile, X-linked recessive",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0010532",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0010532",
                                "name": "spinal muscular atrophy, X-linked type 2",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0010532",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0010532",
                                "name": "spinal muscular atrophy, X-linked 2",
                                "description": ""
                            },
                            {
                                "id": "MIM:301830",
                                "resource": "MIM",
                                "url": "https://www.omim.org/entry/301830",
                                "name": "Spinal muscular atrophy X-linked 2",
                                "description": "Spinal muscular atrophy X-linked 2"
                            }
                        ],
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                        "evidence": [
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                                "id": "301830",
                                "database": "MIM",
                                "url": "https://www.omim.org/entry/301830"
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                                "id": "0111827",
                                "database": "AGR",
                                "url": "https://www.alliancegenome.org/disease/DOID:0111827"
                            }
                        ]
                    },
                    {
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                        "recommended_name": {
                            "id": "DOID:0080828",
                            "resource": "Disease Ontology",
                            "url": "https://disease-ontology.org/term/DOID:0080828",
                            "name": "VEXAS syndrome",
                            "description": "A syndrome that is characterized by blood clots in veins, recurrent fevers, pulmonary abnormalities and vacuoles in myeloid cells and that has_material_basis_in mutation in the UBA1 gene on chromosome Xp11."
                        },
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                            {
                                "id": "DOID:0080828",
                                "resource": "Disease Ontology",
                                "url": "https://disease-ontology.org/term/DOID:0080828",
                                "name": "vacuoles, E1 enzyme, X-linked, autoinflammatory and somatic syndrome",
                                "description": ""
                            },
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                                "url": "https://monarchinitiative.org/disease/MONDO:0026777",
                                "name": "VEXAS syndrome",
                                "description": "An adult-onset inflammatory disease that affects only males and is caused by somatic, not germline, mutations. The disorder is characterized by adult onset of rheumatologic symptoms at a mean age of 64 years. Features include recurrent fevers, pulmonary and dermatologic inflammatory manifestations, vasculitis, deep vein thrombosis, arthralgias, and ear and nose chondritis. Laboratory studies indicate hematologic abnormalities, including macrocytic anemia, as well as increased levels of acute-phase reactants; about half of patients have positive autoantibodies. Bone marrow biopsy shows degenerative vacuolization restricted to myeloid and erythroid precursor cells, as well as variable hematopoietic dyspoiesis and dysplasias. The condition does not respond to rheumatologic medications and the features may result in premature death."
                            },
                            {
                                "id": "MONDO:0026777",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0026777",
                                "name": "VEXAS",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0026777",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0026777",
                                "name": "VEXAS syndrome, somatic",
                                "description": ""
                            },
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                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0026777",
                                "name": "vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic syndrome",
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                            },
                            {
                                "id": "MIM:301054",
                                "resource": "MIM",
                                "url": "https://www.omim.org/entry/301054",
                                "name": "VEXAS syndrome",
                                "description": "VEXAS syndrome"
                            }
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                                "database": "AGR",
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        "title": "VEXAS-Defining UBA1 Somatic Variants in 245,368 Diverse Individuals in the NIH All Of Us Cohort.",
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