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United States of America", "date": "1998", "authors": "Fitzky BU, Witsch-Baumgartner M, Erdel M, Lee JN, Paik YK, Glossmann H, Utermann G, Moebius FF", "reference": { "type": "PubMed", "id": "9653161", "url": "https://pubmed.ncbi.nlm.nih.gov/9653161" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UBM7-1", "protein_name": "7-dehydrocholesterol reductase", "gene_name": "DHCR7", "tax_name": "Human" }, { "uniprot_canonical_ac": "O88455-1", "protein_name": "7-dehydrocholesterol reductase", "gene_name": "Dhcr7", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9UBM7", "url": "https://www.uniprot.org/uniprotkb/Q9UBM7" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9653161", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { 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"Molecules and cells", "date": "2018", "authors": "Wang CH, Shyu RY, Wu CC, Chen ML, Lee MC, Lin YY, Wang LK, Jiang SY, Tsai FM", "reference": { "type": "PubMed", "id": "29902837", "url": "https://pubmed.ncbi.nlm.nih.gov/29902837" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O75937-1", "protein_name": "DnaJ homolog subfamily C member 8", "gene_name": "DNAJC8", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O75937", "url": "https://www.uniprot.org/uniprotkb/O75937" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.29902837", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", 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Decreased VASH1 tyrosine carboxypeptidase activity on alpha-tubulin. Strongly decreased interaction with VASH2. Decreased VASH2 tyrosine carboxypeptidase activity on alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "Q8N300", "url": "https://www.uniprot.org/uniprotkb/Q8N300" }, { "database": "PubMed", "id": "31235911", "url": "https://pubmed.ncbi.nlm.nih.gov/31235911" }, { "database": "PubMed", "id": "31171830", "url": "https://pubmed.ncbi.nlm.nih.gov/31171830" } ], "uniprot_canonical_ac": "Q8N300-1" }, { "start_pos": 39, "end_pos": 40, "sequence_org": "IY", "sequence_mut": "AA", "comment": "Strongly decreased interaction with VASH1. Decreased VASH1 tyrosine carboxypeptidase activity on alpha-tubulin. Disrupted interaction with VASH2. Decreased VASH2 tyrosine carboxypeptidase activity on alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "Q8N300", "url": "https://www.uniprot.org/uniprotkb/Q8N300" }, { "database": "PubMed", "id": "31235911", "url": "https://pubmed.ncbi.nlm.nih.gov/31235911" }, { "database": "PubMed", "id": "31171830", "url": "https://pubmed.ncbi.nlm.nih.gov/31171830" } ], "uniprot_canonical_ac": "Q8N300-1" }, { "start_pos": 42, "end_pos": 43, "sequence_org": "LN", "sequence_mut": "AA", "comment": "Decreased interaction with VASH1. Almost abolished VASH1 tyrosine carboxypeptidase activity on alpha-tubulin. Strongly decreased interaction with VASH2. Decreased VASH2 tyrosine carboxypeptidase activity on alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "Q8N300", "url": "https://www.uniprot.org/uniprotkb/Q8N300" }, { "database": "PubMed", "id": "31235911", "url": "https://pubmed.ncbi.nlm.nih.gov/31235911" }, { "database": "PubMed", "id": "31171830", "url": "https://pubmed.ncbi.nlm.nih.gov/31171830" } ], "uniprot_canonical_ac": "Q8N300-1" }, { "start_pos": 45, "end_pos": 46, "sequence_org": "VM", "sequence_mut": "AA", "comment": "Slightly decreased interaction with VASH1. Decreased VASH1 tyrosine carboxypeptidase activity on alpha-tubulin. No effect on interaction with VASH2. No effect on VASH2 tyrosine carboxypeptidase activity on alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "Q8N300", "url": "https://www.uniprot.org/uniprotkb/Q8N300" }, { "database": "PubMed", "id": "31235911", "url": "https://pubmed.ncbi.nlm.nih.gov/31235911" }, { "database": "PubMed", "id": "31171830", "url": "https://pubmed.ncbi.nlm.nih.gov/31171830" } ], "uniprot_canonical_ac": "Q8N300-1" } ], "record_id": "pubmed.31171830", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Structural basis of tubulin detyrosination by vasohibins.", "journal": "Nature structural & molecular biology", "date": "2019", "authors": "Li F, Hu Y, Qi S, Luo X, Yu H", "reference": { "type": "PubMed", "id": "31235910", "url": "https://pubmed.ncbi.nlm.nih.gov/31235910" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q7L8A9-1", "protein_name": "Tubulinyl-Tyr carboxypeptidase 1", "gene_name": "VASH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N300-1", "protein_name": "Small vasohibin-binding protein", "gene_name": "SVBP", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q7L8A9", "url": "https://www.uniprot.org/uniprotkb/Q7L8A9" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 134, "end_pos": 134, "sequence_org": "Y", "sequence_mut": "A", "comment": "Abolished tyrosine carboxypeptidase activity on alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "Q7L8A9", "url": "https://www.uniprot.org/uniprotkb/Q7L8A9" }, { "database": "PubMed", "id": "31270470", "url": "https://pubmed.ncbi.nlm.nih.gov/31270470" }, { "database": "PubMed", "id": "31171830", "url": "https://pubmed.ncbi.nlm.nih.gov/31171830" }, { "database": "PubMed", "id": "31235910", "url": "https://pubmed.ncbi.nlm.nih.gov/31235910" } ], "uniprot_canonical_ac": "Q7L8A9-1" }, { "start_pos": 134, "end_pos": 134, "sequence_org": "Y", "sequence_mut": "F", "comment": "Abolished tyrosine carboxypeptidase activity on alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "Q7L8A9", "url": "https://www.uniprot.org/uniprotkb/Q7L8A9" }, { "database": "PubMed", "id": "31270470", "url": 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Reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with R-77. Reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with R-81. Abolished tyrosine carboxypeptidase activity on alpha-tubulin; when associated with R-77 and R-81.", "evidence": [ { "database": "UniProtKB", "id": "Q7L8A9", "url": "https://www.uniprot.org/uniprotkb/Q7L8A9" }, { "database": "PubMed", "id": "31235910", "url": "https://pubmed.ncbi.nlm.nih.gov/31235910" } ], "uniprot_canonical_ac": "Q7L8A9-1" }, { "start_pos": 146, "end_pos": 146, "sequence_org": "K", "sequence_mut": "A", "comment": "Abolished tyrosine carboxypeptidase activity on alpha-tubulin. Abolished tyrosine carboxypeptidase activity on alpha-tubulin; when associated with A-222.", "evidence": [ { "database": "UniProtKB", "id": "Q7L8A9", "url": "https://www.uniprot.org/uniprotkb/Q7L8A9" }, { "database": "PubMed", "id": "31270470", "url": "https://pubmed.ncbi.nlm.nih.gov/31270470" }, { "database": "PubMed", "id": "31171830", "url": "https://pubmed.ncbi.nlm.nih.gov/31171830" }, { "database": "PubMed", "id": "31235910", "url": "https://pubmed.ncbi.nlm.nih.gov/31235910" } ], "uniprot_canonical_ac": "Q7L8A9-1" }, { "start_pos": 146, "end_pos": 146, "sequence_org": "K", "sequence_mut": "E", "comment": "Abolished tyrosine carboxypeptidase activity on alpha-tubulin. Abolished tyrosine carboxypeptidase activity on alpha-tubulin; when associated with A-222.", "evidence": [ { "database": "UniProtKB", "id": "Q7L8A9", "url": "https://www.uniprot.org/uniprotkb/Q7L8A9" }, { "database": "PubMed", "id": "31270470", "url": "https://pubmed.ncbi.nlm.nih.gov/31270470" }, { "database": "PubMed", "id": "31171830", "url": "https://pubmed.ncbi.nlm.nih.gov/31171830" }, { "database": "PubMed", "id": "31235910", "url": "https://pubmed.ncbi.nlm.nih.gov/31235910" } ], "uniprot_canonical_ac": "Q7L8A9-1" }, { "start_pos": 168, "end_pos": 168, "sequence_org": "K", "sequence_mut": "E", "comment": "Abolished tyrosine carboxypeptidase activity on alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "Q7L8A9", "url": "https://www.uniprot.org/uniprotkb/Q7L8A9" }, { "database": "PubMed", "id": "31270470", "url": "https://pubmed.ncbi.nlm.nih.gov/31270470" }, { "database": "PubMed", "id": "31235910", "url": "https://pubmed.ncbi.nlm.nih.gov/31235910" } ], "uniprot_canonical_ac": "Q7L8A9-1" }, { "start_pos": 169, "end_pos": 169, "sequence_org": "C", "sequence_mut": "A", "comment": "Abolished tyrosine carboxypeptidase activity on alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "Q7L8A9", "url": "https://www.uniprot.org/uniprotkb/Q7L8A9" }, { "database": "PubMed", "id": "29146869", "url": "https://pubmed.ncbi.nlm.nih.gov/29146869" }, { "database": "PubMed", "id": "31270470", "url": "https://pubmed.ncbi.nlm.nih.gov/31270470" }, { "database": "PubMed", "id": "31171830", "url": "https://pubmed.ncbi.nlm.nih.gov/31171830" }, { "database": "PubMed", "id": "31235910", "url": "https://pubmed.ncbi.nlm.nih.gov/31235910" } ], "uniprot_canonical_ac": "Q7L8A9-1" }, { "start_pos": 169, "end_pos": 169, "sequence_org": "C", "sequence_mut": "S", "comment": "Abolished tyrosine carboxypeptidase activity on alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "Q7L8A9", "url": "https://www.uniprot.org/uniprotkb/Q7L8A9" }, { "database": "PubMed", "id": "29146869", "url": "https://pubmed.ncbi.nlm.nih.gov/29146869" }, { "database": "PubMed", "id": "31270470", "url": "https://pubmed.ncbi.nlm.nih.gov/31270470" }, { "database": "PubMed", "id": "31171830", "url": "https://pubmed.ncbi.nlm.nih.gov/31171830" }, { "database": "PubMed", "id": "31235910", "url": "https://pubmed.ncbi.nlm.nih.gov/31235910" } ], "uniprot_canonical_ac": "Q7L8A9-1" }, { "start_pos": 194, "end_pos": 194, "sequence_org": "K", "sequence_mut": "E", "comment": "No effect on tyrosine carboxypeptidase activity on alpha-tubulin. No effect on tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-256. No effect on tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-258. No effect on tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-276.", "evidence": [ { "database": "UniProtKB", "id": "Q7L8A9", "url": "https://www.uniprot.org/uniprotkb/Q7L8A9" }, { "database": "PubMed", "id": "31270470", "url": "https://pubmed.ncbi.nlm.nih.gov/31270470" }, { "database": "PubMed", "id": "31235910", "url": "https://pubmed.ncbi.nlm.nih.gov/31235910" } ], "uniprot_canonical_ac": "Q7L8A9-1" }, { "start_pos": 203, "end_pos": 203, "sequence_org": "R", "sequence_mut": "E", "comment": "No effect on tyrosine carboxypeptidase activity on alpha-tubulin. Strongly reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-258. Reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-258. Reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-256. Reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-276.", "evidence": [ { "database": "UniProtKB", "id": "Q7L8A9", "url": "https://www.uniprot.org/uniprotkb/Q7L8A9" }, { "database": "PubMed", "id": "31270470", "url": "https://pubmed.ncbi.nlm.nih.gov/31270470" }, { "database": "PubMed", "id": "31235910", "url": "https://pubmed.ncbi.nlm.nih.gov/31235910" } ], "uniprot_canonical_ac": "Q7L8A9-1" }, { "start_pos": 204, "end_pos": 204, "sequence_org": "H", "sequence_mut": "A", "comment": "Abolished tyrosine carboxypeptidase activity on alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "Q7L8A9", "url": "https://www.uniprot.org/uniprotkb/Q7L8A9" }, { "database": "PubMed", "id": "31270470", "url": "https://pubmed.ncbi.nlm.nih.gov/31270470" }, { "database": "PubMed", "id": "31171830", "url": "https://pubmed.ncbi.nlm.nih.gov/31171830" }, { "database": "PubMed", "id": "31235910", "url": "https://pubmed.ncbi.nlm.nih.gov/31235910" } ], "uniprot_canonical_ac": "Q7L8A9-1" }, { "start_pos": 221, "end_pos": 221, "sequence_org": "S", "sequence_mut": "A", "comment": "Abolished tyrosine carboxypeptidase activity on alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "Q7L8A9", "url": "https://www.uniprot.org/uniprotkb/Q7L8A9" }, { "database": "PubMed", "id": "31270470", "url": "https://pubmed.ncbi.nlm.nih.gov/31270470" }, { "database": "PubMed", "id": "31171830", "url": "https://pubmed.ncbi.nlm.nih.gov/31171830" }, { "database": "PubMed", "id": "31235910", "url": "https://pubmed.ncbi.nlm.nih.gov/31235910" } ], "uniprot_canonical_ac": "Q7L8A9-1" }, { "start_pos": 222, "end_pos": 222, "sequence_org": "R", "sequence_mut": "A", "comment": "Abolished tyrosine carboxypeptidase activity on alpha-tubulin. Abolished tyrosine carboxypeptidase activity on alpha-tubulin; when associated with A-146.", "evidence": [ { "database": "UniProtKB", "id": "Q7L8A9", "url": "https://www.uniprot.org/uniprotkb/Q7L8A9" }, { "database": "PubMed", "id": "31270470", "url": "https://pubmed.ncbi.nlm.nih.gov/31270470" }, { "database": "PubMed", "id": "31171830", "url": "https://pubmed.ncbi.nlm.nih.gov/31171830" }, { "database": "PubMed", "id": "31235910", "url": "https://pubmed.ncbi.nlm.nih.gov/31235910" }, { "database": "PubMed", "id": "31235911", "url": "https://pubmed.ncbi.nlm.nih.gov/31235911" } ], "uniprot_canonical_ac": "Q7L8A9-1" }, { "start_pos": 222, "end_pos": 222, "sequence_org": "R", "sequence_mut": "E", "comment": "Abolished tyrosine carboxypeptidase activity on alpha-tubulin. Abolished tyrosine carboxypeptidase activity on alpha-tubulin; when associated with A-146.", "evidence": [ { "database": "UniProtKB", "id": "Q7L8A9", "url": "https://www.uniprot.org/uniprotkb/Q7L8A9" }, { "database": "PubMed", "id": "31270470", "url": "https://pubmed.ncbi.nlm.nih.gov/31270470" }, { "database": "PubMed", "id": "31171830", "url": "https://pubmed.ncbi.nlm.nih.gov/31171830" }, { "database": "PubMed", "id": "31235910", "url": "https://pubmed.ncbi.nlm.nih.gov/31235910" }, { "database": "PubMed", "id": "31235911", "url": "https://pubmed.ncbi.nlm.nih.gov/31235911" } ], "uniprot_canonical_ac": "Q7L8A9-1" }, { "start_pos": 256, "end_pos": 256, "sequence_org": "K", "sequence_mut": "E", "comment": "No effect on tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-194. Reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-203.", "evidence": [ { "database": "UniProtKB", "id": "Q7L8A9", "url": "https://www.uniprot.org/uniprotkb/Q7L8A9" }, { "database": "PubMed", "id": "31235910", "url": "https://pubmed.ncbi.nlm.nih.gov/31235910" } ], "uniprot_canonical_ac": "Q7L8A9-1" }, { "start_pos": 258, "end_pos": 258, "sequence_org": "K", "sequence_mut": "E", "comment": "No effect on tyrosine carboxypeptidase activity on alpha-tubulin. No effect on tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-194. Strognly reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-203.", "evidence": [ { "database": "UniProtKB", "id": "Q7L8A9", "url": "https://www.uniprot.org/uniprotkb/Q7L8A9" }, { "database": "PubMed", "id": "31270470", "url": "https://pubmed.ncbi.nlm.nih.gov/31270470" }, { "database": "PubMed", "id": "31235910", "url": "https://pubmed.ncbi.nlm.nih.gov/31235910" } ], "uniprot_canonical_ac": "Q7L8A9-1" }, { "start_pos": 276, "end_pos": 276, "sequence_org": "K", "sequence_mut": "E", "comment": "No effect on tyrosine carboxypeptidase activity on alpha-tubulin. No effect on tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-194. Reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-203.", "evidence": [ { "database": "UniProtKB", "id": "Q7L8A9", "url": "https://www.uniprot.org/uniprotkb/Q7L8A9" }, { "database": "PubMed", "id": "31270470", "url": "https://pubmed.ncbi.nlm.nih.gov/31270470" }, { "database": "PubMed", "id": "31235910", "url": "https://pubmed.ncbi.nlm.nih.gov/31235910" } ], "uniprot_canonical_ac": "Q7L8A9-1" }, { "start_pos": 77, "end_pos": 77, "sequence_org": "M", "sequence_mut": "R", "comment": "No effect on tyrosine carboxypeptidase activity on alpha-tubulin. Reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with R-141. Abolished tyrosine carboxypeptidase activity on alpha-tubulin; when associated with R-81 and R-141.", "evidence": [ { "database": "UniProtKB", "id": "Q7L8A9", "url": "https://www.uniprot.org/uniprotkb/Q7L8A9" }, { "database": "PubMed", "id": "31235910", "url": "https://pubmed.ncbi.nlm.nih.gov/31235910" } ], "uniprot_canonical_ac": "Q7L8A9-1" }, { "start_pos": 77, "end_pos": 81, "sequence_org": "MWKHV", "sequence_mut": "RWKHR", "comment": "No effect on tyrosine carboxypeptidase activity on alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "Q7L8A9", "url": "https://www.uniprot.org/uniprotkb/Q7L8A9" }, { "database": "PubMed", "id": "31235910", "url": "https://pubmed.ncbi.nlm.nih.gov/31235910" } ], "uniprot_canonical_ac": "Q7L8A9-1" }, { "start_pos": 81, "end_pos": 81, "sequence_org": "V", "sequence_mut": "R", "comment": "No effect on tyrosine carboxypeptidase activity on alpha-tubulin. Reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with R-141. Abolished tyrosine carboxypeptidase activity on alpha-tubulin; when associated with R-77 and R-141.", "evidence": [ { "database": "UniProtKB", "id": "Q7L8A9", "url": "https://www.uniprot.org/uniprotkb/Q7L8A9" }, { "database": "PubMed", "id": "31235910", "url": "https://pubmed.ncbi.nlm.nih.gov/31235910" } ], "uniprot_canonical_ac": "Q7L8A9-1" }, { "start_pos": 39, "end_pos": 39, "sequence_org": "I", "sequence_mut": "E", "comment": "No effect on VASH1 tyrosine carboxypeptidase activity on alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "Q8N300", "url": "https://www.uniprot.org/uniprotkb/Q8N300" }, { "database": "PubMed", "id": "31235910", "url": "https://pubmed.ncbi.nlm.nih.gov/31235910" } ], "uniprot_canonical_ac": "Q8N300-1" }, { "start_pos": 39, "end_pos": 42, "sequence_org": "IYAL", "sequence_mut": "EALE", "comment": "Strongly decreased VASH1 tyrosine carboxypeptidase activity on alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "Q8N300", "url": 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Reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-203.", "evidence": [ { "database": "UniProtKB", "id": "Q7L8A9", "url": "https://www.uniprot.org/uniprotkb/Q7L8A9" }, { "database": "PubMed", "id": "31270470", "url": "https://pubmed.ncbi.nlm.nih.gov/31270470" }, { "database": "PubMed", "id": "31235910", "url": "https://pubmed.ncbi.nlm.nih.gov/31235910" } ], "uniprot_canonical_ac": "Q7L8A9-1" }, { "start_pos": 32, "end_pos": 32, "sequence_org": "K", "sequence_mut": "E", "comment": "Decreased VASH1 tyrosine carboxypeptidase activity on alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "Q8N300", "url": "https://www.uniprot.org/uniprotkb/Q8N300" }, { "database": "PubMed", "id": "31270470", "url": "https://pubmed.ncbi.nlm.nih.gov/31270470" } ], "uniprot_canonical_ac": "Q8N300-1" }, { "start_pos": 34, "end_pos": 34, "sequence_org": "R", "sequence_mut": "E", "comment": "No effect on VASH1 tyrosine carboxypeptidase activity on alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "Q8N300", "url": "https://www.uniprot.org/uniprotkb/Q8N300" }, { "database": "PubMed", "id": "31270470", "url": "https://pubmed.ncbi.nlm.nih.gov/31270470" } ], "uniprot_canonical_ac": "Q8N300-1" }, { "start_pos": 35, "end_pos": 35, "sequence_org": "Q", "sequence_mut": "A", "comment": "Decreased VASH1 tyrosine carboxypeptidase activity on alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "Q8N300", "url": "https://www.uniprot.org/uniprotkb/Q8N300" }, { "database": "PubMed", "id": "31270470", "url": "https://pubmed.ncbi.nlm.nih.gov/31270470" } ], "uniprot_canonical_ac": "Q8N300-1" }, { "start_pos": 36, "end_pos": 36, "sequence_org": "R", "sequence_mut": "E", "comment": "Decreased VASH1 tyrosine carboxypeptidase activity on alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "Q8N300", "url": "https://www.uniprot.org/uniprotkb/Q8N300" }, { "database": "PubMed", "id": "31270470", "url": 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tyrosine carboxypeptidase activity on alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "Q8N300", "url": "https://www.uniprot.org/uniprotkb/Q8N300" }, { "database": "PubMed", "id": "31270470", "url": "https://pubmed.ncbi.nlm.nih.gov/31270470" } ], "uniprot_canonical_ac": "Q8N300-1" } ], "record_id": "pubmed.31270470", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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"glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA.", "journal": "Molecular cell", "date": "1999", "authors": "Gradia S, Subramanian D, Wilson T, Acharya S, Makhov A, Griffith J, Fishel R", "reference": { "type": "PubMed", "id": "10078208", "url": "https://pubmed.ncbi.nlm.nih.gov/10078208" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9HCU8-1", "protein_name": "DNA polymerase delta subunit 4", "gene_name": "POLD4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28340-1", "protein_name": "DNA polymerase delta catalytic subunit", "gene_name": "POLD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35244-1", "protein_name": "Replication protein A 14 kDa subunit", "gene_name": "RPA3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18858-1", "protein_name": "DNA ligase 1", "gene_name": "LIG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27694-1", "protein_name": "Replication protein A 70 kDa DNA-binding subunit", "gene_name": "RPA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P52701-1", "protein_name": "DNA mismatch repair protein Msh6", "gene_name": "MSH6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15054-1", "protein_name": "DNA polymerase delta subunit 3", "gene_name": "POLD3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49005-1", "protein_name": "DNA polymerase delta subunit 2", "gene_name": "POLD2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15927-1", "protein_name": "Replication protein A 32 kDa subunit", "gene_name": "RPA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12004-1", "protein_name": "DNA sliding clamp PCNA", "gene_name": "PCNA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQ84-1", "protein_name": "Exonuclease 1", "gene_name": "EXO1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P43246-1", "protein_name": "DNA mismatch repair protein Msh2", "gene_name": "MSH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54278-1", "protein_name": "Mismatch repair endonuclease PMS2", "gene_name": "PMS2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P40692-1", "protein_name": "DNA mismatch repair protein Mlh1", "gene_name": "MLH1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9HCU8", "url": "https://www.uniprot.org/uniprotkb/Q9HCU8" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10078208", "abstract": "", 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