[
    {
        "title": "Structural requirements for interaction of peroxisomal targeting signal 2 and its receptor PEX7.",
        "journal": "The Journal of biological chemistry",
        "date": "2011",
        "authors": "Kunze M, Neuberger G, Maurer-Stroh S, Ma J, Eck T, Braverman N, Schmid JA, Eisenhaber F, Berger J",
        "reference": {
            "type": "PubMed",
            "id": "22057399",
            "url": "https://pubmed.ncbi.nlm.nih.gov/22057399"
        },
        "referenced_glycans": [],
        "referenced_proteins": [
            {
                "uniprot_canonical_ac": "Q86WA8-1",
                "protein_name": "Lon protease homolog 2, peroxisomal",
                "gene_name": "LONP2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P0C024-1",
                "protein_name": "Peroxisomal coenzyme A diphosphatase NUDT7",
                "gene_name": "NUDT7",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O14832-1",
                "protein_name": "Phytanoyl-CoA dioxygenase, peroxisomal",
                "gene_name": "PHYH",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O15228-1",
                "protein_name": "Dihydroxyacetone phosphate acyltransferase",
                "gene_name": "GNPAT",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P39210-1",
                "protein_name": "Mitochondrial inner membrane protein Mpv17",
                "gene_name": "MPV17",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P22307-1",
                "protein_name": "Sterol carrier protein 2",
                "gene_name": "SCP2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P35914-1",
                "protein_name": "Hydroxymethylglutaryl-CoA lyase, mitochondrial",
                "gene_name": "HMGCL",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "A8MXV4-1",
                "protein_name": "Acyl-coenzyme A diphosphatase NUDT19",
                "gene_name": "NUDT19",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q6PIL6-1",
                "protein_name": "Kv channel-interacting protein 4",
                "gene_name": "KCNIP4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O75381-1",
                "protein_name": "Peroxisomal membrane protein PEX14",
                "gene_name": "PEX14",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q13608-1",
                "protein_name": "Peroxisomal ATPase PEX6",
                "gene_name": "PEX6",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P28328-1",
                "protein_name": "Peroxisome biogenesis factor 2",
                "gene_name": "PEX2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O43933-1",
                "protein_name": "Peroxisomal ATPase PEX1",
                "gene_name": "PEX1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q99489-1",
                "protein_name": "D-aspartate oxidase",
                "gene_name": "DDO",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P61077-1",
                "protein_name": "Ubiquitin-conjugating enzyme E2 D3",
                "gene_name": "UBE2D3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q13011-1",
                "protein_name": "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial",
                "gene_name": "ECH1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P51668-1",
                "protein_name": "Ubiquitin-conjugating enzyme E2 D1",
                "gene_name": "UBE2D1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P04040-1",
                "protein_name": "Catalase",
                "gene_name": "CAT",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P14735-1",
                "protein_name": "Insulin-degrading enzyme",
                "gene_name": "IDE",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9Y2Q3-1",
                "protein_name": "Glutathione S-transferase kappa 1",
                "gene_name": "GSTK1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q7Z412-1",
                "protein_name": "Peroxisome assembly protein 26",
                "gene_name": "PEX26",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9P0Z9-1",
                "protein_name": "Peroxisomal sarcosine oxidase",
                "gene_name": "PIPOX",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q99424-1",
                "protein_name": "Peroxisomal acyl-coenzyme A oxidase 2",
                "gene_name": "ACOX2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q15067-1",
                "protein_name": "Peroxisomal acyl-coenzyme A oxidase 1",
                "gene_name": "ACOX1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q08426-1",
                "protein_name": "Peroxisomal bifunctional enzyme",
                "gene_name": "EHHADH",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9UHK6-1",
                "protein_name": "Alpha-methylacyl-CoA racemase",
                "gene_name": "AMACR",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P35228-1",
                "protein_name": "Nitric oxide synthase, inducible",
                "gene_name": "NOS2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q6FIF0-1",
                "protein_name": "AN1-type zinc finger protein 6",
                "gene_name": "ZFAND6",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q2T9J0-1",
                "protein_name": "Peroxisomal leader peptide-processing protease",
                "gene_name": "TYSND1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P43155-1",
                "protein_name": "Carnitine O-acetyltransferase",
                "gene_name": "CRAT",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P62979-1",
                "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein",
                "gene_name": "RPS27A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P62837-1",
                "protein_name": "Ubiquitin-conjugating enzyme E2 D2",
                "gene_name": "UBE2D2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P51659-1",
                "protein_name": "Peroxisomal multifunctional enzyme type 2",
                "gene_name": "HSD17B4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9UJM8-1",
                "protein_name": "2-Hydroxyacid oxidase 1",
                "gene_name": "HAO1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9UKG9-1",
                "protein_name": "Peroxisomal carnitine O-octanoyltransferase",
                "gene_name": "CROT",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q6QHF9-2",
                "protein_name": "Peroxisomal N(1)-acetyl-spermine/spermidine oxidase",
                "gene_name": "PAOX",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P21549-1",
                "protein_name": "Alanine--glyoxylate aminotransferase",
                "gene_name": "AGXT",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q92968-1",
                "protein_name": "Peroxisomal membrane protein PEX13",
                "gene_name": "PEX13",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O60683-1",
                "protein_name": "Peroxisome biogenesis factor 10",
                "gene_name": "PEX10",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O00623-1",
                "protein_name": "Peroxisome assembly protein 12",
                "gene_name": "PEX12",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O00628-1",
                "protein_name": "Peroxisomal targeting signal 2 receptor",
                "gene_name": "PEX7",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9BY49-1",
                "protein_name": "Peroxisomal trans-2-enoyl-CoA reductase",
                "gene_name": "PECR",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9UJ83-1",
                "protein_name": "2-hydroxyacyl-CoA lyase 1",
                "gene_name": "HACL1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9NYQ3-1",
                "protein_name": "2-Hydroxyacid oxidase 2",
                "gene_name": "HAO2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q93008-1",
                "protein_name": "Ubiquitin carboxyl-terminal hydrolase 9X",
                "gene_name": "USP9X",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O14975-1",
                "protein_name": "Long-chain fatty acid transport protein 2",
                "gene_name": "SLC27A2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q14032-1",
                "protein_name": "Bile acid-CoA:amino acid N-acyltransferase",
                "gene_name": "BAAT",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P0CG47-1",
                "protein_name": "Polyubiquitin-B",
                "gene_name": "UBB",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P62987-1",
                "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein",
                "gene_name": "UBA52",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P09110-1",
                "protein_name": "3-ketoacyl-CoA thiolase, peroxisomal",
                "gene_name": "ACAA1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9NUI1-1",
                "protein_name": "Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]",
                "gene_name": "DECR2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9BTZ2-1",
                "protein_name": "Dehydrogenase/reductase SDR family member 4",
                "gene_name": "DHRS4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O75874-1",
                "protein_name": "Isocitrate dehydrogenase [NADP] cytoplasmic",
                "gene_name": "IDH1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P34913-1",
                "protein_name": "Bifunctional epoxide hydrolase 2",
                "gene_name": "EPHX2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O00116-1",
                "protein_name": "Alkyldihydroxyacetonephosphate synthase, peroxisomal",
                "gene_name": "AGPS",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O14734-1",
                "protein_name": "Acyl-coenzyme A thioesterase 8",
                "gene_name": "ACOT8",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "P49753-1",
                "protein_name": "Acyl-coenzyme A thioesterase 2, mitochondrial",
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                "tax_name": "Human"
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            {
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                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "P14920-1",
                "protein_name": "D-amino-acid oxidase",
                "gene_name": "DAO",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "P0CG48-1",
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                "gene_name": "UBC",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "O15254-1",
                "protein_name": "Peroxisomal acyl-coenzyme A oxidase 3",
                "gene_name": "ACOX3",
                "tax_name": "Human"
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        ],
        "species": [
            {
                "name": "Homo sapiens",
                "taxid": 9606,
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                ],
                "common_name": "Human",
                "glygen_name": "Human",
                "reference_species": "Homo sapiens [9606]"
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        ],
        "mutagenesis": [
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                "start_pos": 113,
                "end_pos": 113,
                "sequence_org": "E",
                "sequence_mut": "R",
                "comment": "Impaired binding to cargo proteins containing a PTS2 peroxisomal targeting signal.",
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                ],
                "uniprot_canonical_ac": "O00628-1"
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            {
                "start_pos": 200,
                "end_pos": 200,
                "sequence_org": "E",
                "sequence_mut": "R",
                "comment": "Impaired binding to cargo proteins containing a PTS2 peroxisomal targeting signal.",
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                "start_pos": 287,
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                "sequence_org": "E",
                "sequence_mut": "R",
                "comment": "Impaired interaction with PEX5, leading to decreased peroxisomal import of proteins containing a PTS2 peroxisomal targeting signal.",
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                "comment": "In S3E mutant; Abolished localization to peroxisomes.",
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    {
        "title": "Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate.",
        "journal": "The Journal of biological chemistry",
        "date": "2012",
        "authors": "Grou CP, Francisco T, Rodrigues TA, Freitas MO, Pinto MP, Carvalho AF, Domingues P, Wood SA, Rodriguez-Borges JE, Sa-Miranda C, Fransen M, Azevedo JE",
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        "title": "Pex5p imports folded tetrameric catalase by interaction with Pex13p.",
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        "authors": "Otera H, Fujiki Y",
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        "title": "Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activity.",
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        "title": "A cargo-centered perspective on the PEX5 receptor-mediated peroxisomal protein import pathway.",
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    {
        "title": "A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes.",
        "journal": "The Journal of biological chemistry",
        "date": "2014",
        "authors": "Neuhaus A, Kooshapur H, Wolf J, Meyer NH, Madl T, Saidowsky J, Hambruch E, Lazam A, Jung M, Sattler M, Schliebs W, Erdmann R",
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                "protein_name": "Phytanoyl-CoA dioxygenase, peroxisomal",
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                "protein_name": "Sterol carrier protein 2",
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            },
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                "uniprot_canonical_ac": "P14735-1",
                "protein_name": "Insulin-degrading enzyme",
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            },
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                "uniprot_canonical_ac": "P21549-1",
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                "protein_name": "Peroxisomal targeting signal 2 receptor",
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                "protein_name": "Peroxisomal trans-2-enoyl-CoA reductase",
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            {
                "uniprot_canonical_ac": "Q9UJ83-1",
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                "uniprot_canonical_ac": "Q93008-1",
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        "abstract": "",
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    {
        "title": "AAA peroxins and their recruiter Pex26p modulate the interactions of peroxins involved in peroxisomal protein import.",
        "journal": "The Journal of biological chemistry",
        "date": "2014",
        "authors": "Tamura S, Matsumoto N, Takeba R, Fujiki Y",
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    {
        "title": "Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.",
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        "authors": "Freund A, Zhong FL, Venteicher AS, Meng Z, Veenstra TD, Frydman J, Artandi SE",
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    {
        "title": "Mechanistic insights into PTS2-mediated peroxisomal protein import: the co-receptor PEX5L drastically increases the interaction strength between the cargo protein and the receptor PEX7.",
        "journal": "The Journal of biological chemistry",
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    {
        "title": "The peroxisomal protein import machinery displays a preference for monomeric substrates.",
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        "title": "Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts.",
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    {
        "title": "Revisiting the intraperoxisomal pathway of mammalian PEX7.",
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        "authors": "Rodrigues TA, Grou CP, Azevedo JE",
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    {
        "title": "ATM functions at the peroxisome to induce pexophagy in response to ROS.",
        "journal": "Nature cell biology",
        "date": "2015",
        "authors": "Zhang J, Tripathi DN, Jing J, Alexander A, Kim J, Powell RT, Dere R, Tait-Mulder J, Lee JH, Paull TT, Pandita RK, Charaka VK, Pandita TK, Kastan MB, Walker CL",
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        "title": "PEX2 is the E3 ubiquitin ligase required for pexophagy during starvation.",
        "journal": "The Journal of cell biology",
        "date": "2016",
        "authors": "Sargent G, van Zutphen T, Shatseva T, Zhang L, Di Giovanni V, Bandsma R, Kim PK",
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    {
        "title": "The peroxisomal AAA ATPase complex prevents pexophagy and development of peroxisome biogenesis disorders.",
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        "authors": "Law KB, Bronte-Tinkew D, Di Pietro E, Snowden A, Jones RO, Moser A, Brumell JH, Braverman N, Kim PK",
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    {
        "title": "The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo.",
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        "date": "2017",
        "authors": "Dias AF, Rodrigues TA, Pedrosa AG, Barros-Barbosa A, Francisco T, Azevedo JE",
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        "title": "Protein transport into peroxisomes: Knowns and unknowns.",
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        "title": "Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders.",
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        "authors": "Dodt G, Braverman N, Wong C, Moser A, Moser HW, Watkins P, Valle D, Gould SJ",
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        "title": "Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders.",
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    {
        "title": "Characterization of the yeast and human receptors for the carboxy-terminal tripeptide peroxisomal targeting signal.",
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    {
        "title": "Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor.",
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        "abstract": "",
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    {
        "title": "Multiple PEX genes are required for proper subcellular distribution and stability of Pex5p, the PTS1 receptor: evidence that PTS1 protein import is mediated by a cycling receptor.",
        "journal": "The Journal of cell biology",
        "date": "1996",
        "authors": "Dodt G, Gould SJ",
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        "title": "Human PEX7 encodes the peroxisomal PTS2 receptor and is responsible for rhizomelic chondrodysplasia punctata.",
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        "title": "Rhizomelic chondrodysplasia punctata is a peroxisomal protein targeting disease caused by a non-functional PTS2 receptor.",
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        "title": "Rhizomelic chondrodysplasia punctata is caused by deficiency of human PEX7, a homologue of the yeast PTS2 receptor.",
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        "authors": "Purdue PE, Zhang JW, Skoneczny M, Lazarow PB",
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        "abstract": "",
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    {
        "title": "Human PEX1 cloned by functional complementation on a CHO cell mutant is responsible for peroxisome-deficient Zellweger syndrome of complementation group I.",
        "journal": "Proceedings of the National Academy of Sciences of the United States of America",
        "date": "1998",
        "authors": "Tamura S, Okumoto K, Toyama R, Shimozawa N, Tsukamoto T, Suzuki Y, Osumi T, Kondo N, Fujiki Y",
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        "title": "Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import.",
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        "title": "An isoform of pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes.",
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        "title": "Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT.",
        "journal": "Molecular and cellular biology",
        "date": "1998",
        "authors": "Won KA, Schumacher RJ, Farr GW, Horwich AL, Reed SI",
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                "taxid": 9606,
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        "title": "The difference in recognition of terminal tripeptides as peroxisomal targeting signal 1 between yeast and human is due to different affinities of their receptor Pex5p to the cognate signal and to residues adjacent to it.",
        "journal": "The Journal of biological chemistry",
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    {
        "title": "Role of the chaperonin CCT/TRiC complex in G protein betagamma-dimer assembly.",
        "journal": "The Journal of biological chemistry",
        "date": "2006",
        "authors": "Wells CA, Dingus J, Hildebrandt JD",
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    {
        "title": "Mechanism of assembly of G protein betagamma subunits by protein kinase CK2-phosphorylated phosducin-like protein and the cytosolic chaperonin complex.",
        "journal": "The Journal of biological chemistry",
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        "title": "Retinal cone photoreceptors require phosducin-like protein 1 for G protein complex assembly and signaling.",
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        "title": "Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity.",
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        "title": "The noncatalytic portion of human UDP-glucose: glycoprotein glucosyltransferase I confers UDP-glucose binding and transferase function to the catalytic domain.",
        "journal": "The Journal of biological chemistry",
        "date": "2003",
        "authors": "Arnold SM, Kaufman RJ",
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