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            "id": "25713138",
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            {
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                "protein_name": "Emerin",
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            {
                "uniprot_canonical_ac": "Q9P0L0-1",
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            {
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            {
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                "tax_name": "Human"
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            {
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                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "Q9Y6X1-1",
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            {
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                "protein_name": "Syntaxin-1A",
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                "uniprot_canonical_ac": "P05067-1",
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            {
                "uniprot_canonical_ac": "Q7L5D6-1",
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                "comment": "No effect on interaction with UBL4A. No effect on interaction with UBL4A; when associated with A-1078. Abolishes on interaction with UBL4A; when associated with R-1085.",
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            {
                "start_pos": 1078,
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                "sequence_org": "P",
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                "comment": "No effect on interaction with UBL4A. No effect on interaction with UBL4A; when associated with R-1067 or R-1085.",
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                "uniprot_canonical_ac": "P46379-1"
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            {
                "start_pos": 1085,
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                "sequence_org": "L",
                "sequence_mut": "R",
                "comment": "No effect on interaction with UBL4A. No effect on interaction with UBL4A; when associated with R-1078. Abolishes on interaction with UBL4A; when associated with R-1067.",
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                "sequence_org": "D",
                "sequence_mut": "H",
                "comment": "No effect on interaction with UBL4A.",
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                    {
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                "uniprot_canonical_ac": "P46379-1"
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            {
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                "sequence_org": "V",
                "sequence_mut": "E",
                "comment": "No effect on interaction with BAG6.",
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                    {
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                "uniprot_canonical_ac": "P11441-1"
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            {
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                "sequence_org": "V",
                "sequence_mut": "K",
                "comment": "No effect on interaction with BAG6.",
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                    {
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                        "id": "P11441",
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                    {
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                        "url": "https://pubmed.ncbi.nlm.nih.gov/25713138"
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                "uniprot_canonical_ac": "P11441-1"
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            {
                "start_pos": 105,
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                "sequence_org": "R",
                "sequence_mut": "E",
                "comment": "No effect on interaction with BAG6.",
                "evidence": [
                    {
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                        "id": "P11441",
                        "url": "https://www.uniprot.org/uniprotkb/P11441"
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                    {
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                "uniprot_canonical_ac": "P11441-1"
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    {
        "title": "Emery-Dreifuss muscular dystrophy mutations impair TRC40-mediated targeting of emerin to the inner nuclear membrane.",
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    {
        "title": "PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.",
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        "title": "Tyrosine 87 is vital for the activity of human protein arginine methyltransferase 3 (PRMT3).",
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        "title": "JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation.",
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        "authors": "Liu F, Zhao X, Perna F, Wang L, Koppikar P, Abdel-Wahab O, Harr MW, Levine RL, Xu H, Tefferi A, Deblasio A, Hatlen M, Menendez S, Nimer SD",
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