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No effect on SRC-induced enzyme activity. Little effect on TRAF6-mediated activation of NF-kappa-B. Decreased binding to KPNB1/importin-beta.", "evidence": [ { "database": "UniProtKB", "id": "P41743", "url": "https://www.uniprot.org/uniprotkb/P41743" }, { "database": "PubMed", "id": "11891849", "url": "https://pubmed.ncbi.nlm.nih.gov/11891849" }, { "database": "PubMed", "id": "11713277", "url": "https://pubmed.ncbi.nlm.nih.gov/11713277" } ], "uniprot_canonical_ac": "P41743-1" }, { "start_pos": 280, "end_pos": 280, "sequence_org": "Y", "sequence_mut": "F", "comment": "No effect on the SRC-mediated phosphorylation state. No effect on SRC-induced enzyme activity. No effect on TRAF6-mediated activation of NF-kappa-B.", "evidence": [ { "database": "UniProtKB", "id": "P41743", "url": "https://www.uniprot.org/uniprotkb/P41743" }, { "database": "PubMed", "id": "11713277", "url": "https://pubmed.ncbi.nlm.nih.gov/11713277" } ], "uniprot_canonical_ac": "P41743-1" }, { "start_pos": 334, "end_pos": 334, "sequence_org": "Y", "sequence_mut": "F", "comment": "No effect on the SRC-mediated phosphorylation state. Significant reduction of SRC-induced enzyme activity. Greatly reduced TRAF6-mediated activation of NF-kappa-B. Reduces NGF-dependent cell survival.", "evidence": [ { "database": "UniProtKB", "id": "P41743", "url": "https://www.uniprot.org/uniprotkb/P41743" }, { "database": "PubMed", "id": "11713277", "url": "https://pubmed.ncbi.nlm.nih.gov/11713277" } ], "uniprot_canonical_ac": "P41743-1" } ], "phosphorylation": [ { "start_pos": 265, "end_pos": 265, "kinase_uniprot_canonical_ac": "P12931-1", "kinase_gene_name": "SRC", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P41743", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P41743" }, { "database": "PubMed", "id": "11713277", "url": "https://pubmed.ncbi.nlm.nih.gov/11713277" }, { "database": "PubMed", "id": "16452474", "url": "https://pubmed.ncbi.nlm.nih.gov/16452474" } ], "site_lbl": "Tyr265", "uniprot_canonical_ac": "P41743-1" }, { "start_pos": 265, "end_pos": 265, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine; by SRC", "evidence": [ { "database": "UniProtKB", "id": "P41743", "url": "https://www.uniprot.org/uniprotkb/P41743" }, { "database": "iPTMnet", "id": "P41743", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P41743" }, { "database": "PubMed", "id": "11891849", "url": "https://pubmed.ncbi.nlm.nih.gov/11891849" }, { "database": "PubMed", "id": "11713277", "url": "https://pubmed.ncbi.nlm.nih.gov/11713277" } ], "site_lbl": "Tyr265", "uniprot_canonical_ac": "P41743-1" }, { "start_pos": 280, "end_pos": 280, "kinase_uniprot_canonical_ac": "P12931-1", "kinase_gene_name": "SRC", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P41743", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P41743" }, { "database": "PubMed", "id": "11713277", "url": "https://pubmed.ncbi.nlm.nih.gov/11713277" }, { "database": "PubMed", "id": "16452474", "url": "https://pubmed.ncbi.nlm.nih.gov/16452474" } ], "site_lbl": "Tyr280", "uniprot_canonical_ac": "P41743-1" }, { "start_pos": 280, "end_pos": 280, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine; by SRC", "evidence": [ { "database": "UniProtKB", "id": "P41743", "url": "https://www.uniprot.org/uniprotkb/P41743" }, { "database": "iPTMnet", "id": "P41743", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P41743" }, { "database": "PubMed", "id": "11713277", "url": "https://pubmed.ncbi.nlm.nih.gov/11713277" } ], "site_lbl": "Tyr280", "uniprot_canonical_ac": "P41743-1" }, { "start_pos": 334, "end_pos": 334, "kinase_uniprot_canonical_ac": "P12931-1", "kinase_gene_name": "SRC", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P41743", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P41743" }, { "database": "PubMed", "id": "11713277", "url": "https://pubmed.ncbi.nlm.nih.gov/11713277" }, { "database": "PubMed", "id": "16452474", "url": "https://pubmed.ncbi.nlm.nih.gov/16452474" } ], "site_lbl": "Tyr334", "uniprot_canonical_ac": "P41743-1" }, { "start_pos": 334, "end_pos": 334, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine; by SRC", "evidence": [ { "database": "UniProtKB", "id": "P41743", "url": "https://www.uniprot.org/uniprotkb/P41743" }, { "database": "iPTMnet", "id": "P41743", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P41743" }, { "database": "PubMed", "id": "11713277", "url": "https://pubmed.ncbi.nlm.nih.gov/11713277" } ], "site_lbl": "Tyr334", "uniprot_canonical_ac": "P41743-1" } ], "record_id": "pubmed.11713277", "abstract": "", "glycosylation": [], "snv": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Structure of a cell polarity regulator, a complex between atypical PKC and Par6 PB1 domains.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Hirano Y, Yoshinaga S, Takeya R, Suzuki NN, Horiuchi M, Kohjima M, Sumimoto H, Inagaki F", "reference": { "type": "PubMed", "id": "15590654", "url": "https://pubmed.ncbi.nlm.nih.gov/15590654" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P41743-1", "protein_name": "Protein kinase C iota type", "gene_name": "PRKCI", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NPB6-1", "protein_name": "Partitioning defective 6 homolog alpha", "gene_name": "PARD6A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P41743", "url": "https://www.uniprot.org/uniprotkb/P41743" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 72, "end_pos": 72, "sequence_org": "D", "sequence_mut": "A", "comment": "Loss of interaction with ECT2, PARD6A and with SQSTM1.", "evidence": [ { "database": "UniProtKB", "id": "P41743", "url": "https://www.uniprot.org/uniprotkb/P41743" }, { "database": "PubMed", "id": "19617897", "url": "https://pubmed.ncbi.nlm.nih.gov/19617897" }, { "database": "PubMed", "id": "15143057", "url": "https://pubmed.ncbi.nlm.nih.gov/15143057" }, { "database": "PubMed", "id": "15590654", "url": "https://pubmed.ncbi.nlm.nih.gov/15590654" } ], "uniprot_canonical_ac": "P41743-1" }, { "start_pos": 85, "end_pos": 85, "sequence_org": "E", "sequence_mut": "A", "comment": "Slight decrease of interaction with PARD6A. 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Loss of interaction with PARD6A; when associated with A-85.", "evidence": [ { "database": "UniProtKB", "id": "P41743", "url": "https://www.uniprot.org/uniprotkb/P41743" }, { "database": "PubMed", "id": "15590654", "url": "https://pubmed.ncbi.nlm.nih.gov/15590654" } ], "uniprot_canonical_ac": "P41743-1" }, { "start_pos": 19, "end_pos": 19, "sequence_org": "K", "sequence_mut": "A", "comment": "Loss of interaction with ECT2 and PRKCI.", "evidence": [ { "database": "UniProtKB", "id": "Q9NPB6", "url": "https://www.uniprot.org/uniprotkb/Q9NPB6" }, { "database": "PubMed", "id": "19617897", "url": "https://pubmed.ncbi.nlm.nih.gov/19617897" }, { "database": "PubMed", "id": "15590654", "url": "https://pubmed.ncbi.nlm.nih.gov/15590654" } ], "uniprot_canonical_ac": "Q9NPB6-1" }, { "start_pos": 28, "end_pos": 28, "sequence_org": "R", "sequence_mut": "A", "comment": "Slight decrease of interaction with PRKCI. 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