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Struct. Biol.", "date": "1999", "authors": "Rossjohn J, Cappai R, Feil S C, Henry A, McKinstry W J, Galatis D, Hesse L, Multhaup G, Beyreuther K, Masters C L, Parker M W", "reference": { "type": "PubMed", "id": "10201399", "url": "https://pubmed.ncbi.nlm.nih.gov/10201399" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P05067-1", "protein_name": "Amyloid-beta precursor protein", "gene_name": "APP", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P05067", "url": "https://www.uniprot.org/uniprotkb/P05067" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10201399", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ 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Little APP internalization. Reduced amyloid-beta protein 42 secretion.", "evidence": [ { "database": "UniProtKB", "id": "P05067", "url": "https://www.uniprot.org/uniprotkb/P05067" }, { "database": "PubMed", "id": "10383380", "url": "https://pubmed.ncbi.nlm.nih.gov/10383380" }, { "database": "PubMed", "id": "8887653", "url": "https://pubmed.ncbi.nlm.nih.gov/8887653" } ], "uniprot_canonical_ac": "P05067-1" }, { "start_pos": 760, "end_pos": 760, "sequence_org": "P", "sequence_mut": "A", "comment": "Little APP internalization. Reduced amyloid-beta protein 42 secretion.", "evidence": [ { "database": "UniProtKB", "id": "P05067", "url": "https://www.uniprot.org/uniprotkb/P05067" }, { "database": "PubMed", "id": "10383380", "url": "https://pubmed.ncbi.nlm.nih.gov/10383380" } ], "uniprot_canonical_ac": "P05067-1" }, { "start_pos": 762, "end_pos": 762, "sequence_org": "Y", "sequence_mut": "A", "comment": "Loss of binding to APBA1 and APBB1. APP internalization unchanged. No change in amyloid-beta protein 42 secretion.", "evidence": [ { "database": "UniProtKB", "id": "P05067", "url": "https://www.uniprot.org/uniprotkb/P05067" }, { "database": "PubMed", "id": "10383380", "url": "https://pubmed.ncbi.nlm.nih.gov/10383380" }, { "database": "PubMed", "id": "8887653", "url": "https://pubmed.ncbi.nlm.nih.gov/8887653" } ], "uniprot_canonical_ac": "P05067-1" } ], "record_id": "pubmed.10383380", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Cysteine 144 is a key residue in the copper reduction by the beta-amyloid precursor protein.", "journal": "Journal of neurochemistry", "date": "1999", "authors": "Ruiz FH, Gonzalez M, Bodini M, Opazo C, Inestrosa NC", "reference": { "type": "PubMed", "id": "10461923", "url": "https://pubmed.ncbi.nlm.nih.gov/10461923" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P05067-1", "protein_name": "Amyloid-beta precursor protein", "gene_name": "APP", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P05067", "url": "https://www.uniprot.org/uniprotkb/P05067" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 144, "end_pos": 144, "sequence_org": "C", "sequence_mut": "S", "comment": "Binds copper. No dimer formation. No copper reducing activity.", "evidence": [ { "database": "UniProtKB", "id": "P05067", "url": "https://www.uniprot.org/uniprotkb/P05067" }, { "database": "PubMed", "id": "10461923", "url": "https://pubmed.ncbi.nlm.nih.gov/10461923" }, { "database": "PubMed", "id": "7913895", "url": "https://pubmed.ncbi.nlm.nih.gov/7913895" } ], "uniprot_canonical_ac": "P05067-1" }, { "start_pos": 147, "end_pos": 149, "sequence_org": "HLH", "sequence_mut": "ALA", "comment": "50% decrease in copper reducing activity.", "evidence": [ { "database": "UniProtKB", "id": "P05067", "url": "https://www.uniprot.org/uniprotkb/P05067" }, { "database": "PubMed", "id": "10461923", "url": "https://pubmed.ncbi.nlm.nih.gov/10461923" } ], "uniprot_canonical_ac": "P05067-1" } ], "record_id": "pubmed.10461923", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ 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Houlden H, Lilius L, Winblad B, Lannfelt L", "reference": { "type": "PubMed", "id": "1302033", "url": "https://pubmed.ncbi.nlm.nih.gov/1302033" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P05067-1", "protein_name": "Amyloid-beta precursor protein", "gene_name": "APP", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P05067", "url": "https://www.uniprot.org/uniprotkb/P05067" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.1302033", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", 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[] } ] }, { "title": "More missense in amyloid gene.", "journal": "Nature genetics", "date": "1992", "authors": "Carter DA, Desmarais E, Bellis M, Campion D, Clerget-Darpoux F, Brice A, Agid Y, Jaillard-Serradt A, Mallet J", "reference": { "type": "PubMed", "id": "1303275", "url": "https://pubmed.ncbi.nlm.nih.gov/1303275" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P05067-1", "protein_name": "Amyloid-beta precursor protein", "gene_name": "APP", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P05067", "url": "https://www.uniprot.org/uniprotkb/P05067" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.1303275", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": 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