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    {
        "title": "Mutant Allele-Specific Uncoupling of PENETRATION3 Functions Reveals Engagement of the ATP-Binding Cassette Transporter in Distinct Tryptophan Metabolic Pathways.",
        "journal": "Plant physiology",
        "date": "2015-07",
        "authors": "Lu Xunli, Dittgen Jan, Pi\u015blewska-Bednarek Mariola, Molina Antonio, Schneider Bernd, Svato\u0161 Ale\u0161, Doubsk\u00fd Jan, Schneeberger Korbinian, Weigel Detlef, Bednarek Pawe\u0142, Schulze-Lefert Paul",
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            "id": "26023163",
            "url": "https://pubmed.ncbi.nlm.nih.gov/26023163"
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                "uniprot_canonical_ac": "Q9XIE2-1",
                "protein_name": "ABC transporter G family member 36",
                "gene_name": "ABCG36",
                "tax_name": "Mouse-ear cress"
            }
        ],
        "species": [
            {
                "name": "Arabidopsis thaliana",
                "taxid": 3702,
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                        "id": "Q9XIE2",
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                ],
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                "glygen_name": "Arabidopsis",
                "reference_species": "Arabidopsis thaliana [3702]"
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        ],
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            {
                "start_pos": 1357,
                "end_pos": 1357,
                "sequence_org": "A",
                "sequence_mut": "V",
                "comment": "In pdr8-115 and pen3-6; slight overaccumulation in leaves of 4-O-beta-D-glucosyl-indol-3-yl formamide (4OGlcI3F) upon Blumeria graminis conidiospore inoculation, a pathogen-inducible tryptophan-derived compound, which biosynthesis is dependent on the PEN2 metabolic pathway. Hypersensitivity to root growth inhibition by 2,4-dichlorophenoxybutyric acid (2,4-DB), an analog of indole 3-butyric acid (IBA), an auxin precursor. Fully defective in preinvasive defense to nonadapted powdery mildews (e.g. Blumeria graminis and Erysiphe pisi). Normal susceptibility to the host-adapted pathogen Golovinomyces orontii associated with normal salicylic acid (SA), and pathogen-inducible hydrogen peroxides levels. Retained microbe-associated molecular patterns (MAMPs)-induced (e.g. flg22) callose deposition. Suppressor of a subset of ibr5 mutant phenotypes including IBA sensitivity but without suppressing ibr5 resistance to indole-3-acetic acid (IAA). Normal accumulation (at protein level).",
                "evidence": [
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                "start_pos": 354,
                "end_pos": 354,
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                "comment": "In pen3-1; overaccumulation in leaves of 4-O-beta-D-glucosyl-indol-3-yl formamide (4OGlcI3F) upon Blumeria graminis conidiospore inoculation, a pathogen-inducible tryptophan-derived compound, which biosynthesis is dependent on the PEN2 metabolic pathway. More susceptible to the necrotrophic pathogen Plectosphaerella cucumerina, with higher frequency of fungal penetration and increased formation of elongating secondary hyphae after the first haustorium development. Fully defective in preinvasive defense to nonadapted powdery mildews (e.g. Blumeria graminis and Erysiphe pisi). Extensive leaf chlorosis and reduced fungal growth upon infection by the host-adapted pathogen Golovinomyces orontii associated with a hyperaccumulation of both free and total salicylic acid (SA) as well as pathogen-inducible hydrogen peroxides in leaves. Impaired microbe-associated molecular patterns (MAMPs)-induced (e.g. flg22) callose deposition. Hypersensitivity to root growth inhibition by indole 3-butyric acid (IBA), an auxin precursor. Reduced accumulation (at protein level).",
                "evidence": [
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                        "id": "26023163",
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            {
                "start_pos": 704,
                "end_pos": 704,
                "sequence_org": "L",
                "sequence_mut": "F",
                "comment": "In pen3-5; slight overaccumulation in leaves of 4-O-beta-D-glucosyl-indol-3-yl formamide (4OGlcI3F) upon Blumeria graminis conidiospore inoculation, a pathogen-inducible tryptophan-derived compound, which biosynthesis is dependent on the PEN2 metabolic pathway. Fully defective in preinvasive defense to nonadapted powdery mildews (e.g. Blumeria graminis and Erysiphe pisi). Normal susceptibility to the host-adapted pathogen Golovinomyces orontii associated with normal salicylic acid (SA) pathogen-inducible hydrogen peroxides levels. Retained microbe-associated molecular patterns (MAMPs)-induced (e.g. flg22) callose deposition. Increased susceptibility to the necrotrophic pathogen Plectosphaerella cucumerina. Enhancer mutation of the mutant pen2-dependent invasive growth of Blumeria graminis. Normal insensitivity to indole-3-butyric acid (IBA), an auxin precursor. Normal accumulation (at protein level).",
                "evidence": [
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                "sequence_mut": "S",
                "comment": "In pen3-2; overaccumulation in leaves of 4-O-beta-D-glucosyl-indol-3-yl formamide (4OGlcI3F) upon Blumeria graminis conidiospore inoculation, a pathogen-inducible tryptophan-derived compound, which biosynthesis is dependent on the PEN2 metabolic pathway. More susceptible to the necrotrophic pathogen P.cucumerina, with higher frequency of fungal penetration and increased formation of elongating secondary hyphae after the first haustorium development. Fully defective in preinvasive defense to nonadapted powdery mildews (e.g. Blumeria graminis and Erysiphe pisi). Extensive leaf chlorosis and reduced fungal growth upon infection by the host-adapted pathogen Golovinomyces orontii associated with an hyperaccumulation of both free and total salicylic acid (SA) as well as pathogen-inducible hydrogen peroxides in leaves. Impaired microbe-associated molecular patterns (MAMPs)-induced (e.g. flg22) callose deposition. Hypersensitivity to root growth inhibition by indole 3-butyric acid (IBA), an auxin precursor. Reduced accumulation (at protein level).",
                "evidence": [
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                        "id": "Q9XIE2",
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    {
        "title": "A framework for lateral membrane trafficking and polar tethering of the PEN3 ATP-binding cassette transporter.",
        "journal": "Plant Physiol.",
        "date": "2016",
        "authors": "Mao Hailiang, Nakamura Moritaka, Viotti Corrado, Grebe Markus",
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                "uniprot_canonical_ac": "Q9XIE2-1",
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                "tax_name": "Mouse-ear cress"
            },
            {
                "uniprot_canonical_ac": "P53492-1",
                "protein_name": "Actin-7",
                "gene_name": "ACT7",
                "tax_name": "Mouse-ear cress"
            },
            {
                "uniprot_canonical_ac": "Q9LTB0-1",
                "protein_name": "Exocyst complex component EXO84B",
                "gene_name": "EXO84B",
                "tax_name": "Mouse-ear cress"
            }
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            }
        ],
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            {
                "start_pos": 108,
                "end_pos": 108,
                "sequence_org": "T",
                "sequence_mut": "I",
                "comment": "In act7-8; impaired trafficking and endocytic recycling of ABCG36/PEN3 between the trans-Golgi network and the plasma membrane in root epidermal and cap cells.",
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            },
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                "sequence_mut": "E",
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