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by activating the JAK1/STAT3 pathway via sponging miR-194-5p.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2022-10", "authors": "Zhang Zhe, Sun Chengying, Zheng Yan, Gong Yanying", "reference": { "type": "PubMed", "id": "35708677", "url": "https://pubmed.ncbi.nlm.nih.gov/35708677" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q0JRZ9-1", "protein_name": "F-BAR domain only protein 2", "gene_name": "FCHO2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q0JRZ9", "url": "https://www.uniprot.org/uniprotkb/Q0JRZ9" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.35708677", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], 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"n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha).", "journal": "The Journal of biological chemistry", "date": "2003-03-14", "authors": "Schreiber Sylvia N, Knutti Darko, Brogli Kathrin, Uhlmann Thomas, Kralli Anastasia", "reference": { "type": "PubMed", "id": "12522104", "url": "https://pubmed.ncbi.nlm.nih.gov/12522104" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P11474-1", "protein_name": "Steroid hormone receptor ERR1", "gene_name": "ESRRA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P11474", "url": "https://www.uniprot.org/uniprotkb/P11474" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.12522104", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha.", "journal": "J. Biol. Chem.", "date": "2004", "authors": "Kallen Joerg, Schlaeppi Jean-Marc, Bitsch Francis, Filipuzzi Ireos, Schilb Alain, Riou Virginie, Graham Alexander, Strauss Andre, Geiser Martin, Fournier Brigitte", "reference": { "type": "PubMed", "id": "15337744", "url": "https://pubmed.ncbi.nlm.nih.gov/15337744" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P11474-1", "protein_name": "Steroid hormone receptor ERR1", "gene_name": "ESRRA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P11474", "url": "https://www.uniprot.org/uniprotkb/P11474" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.15337744", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "A single nucleotide in an estrogen-related receptor alpha site can dictate mode of binding and peroxisome proliferator-activated receptor gamma coactivator 1alpha activation of target promoters.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2006", "authors": "Barry JB, Laganiere J, Giguere V", "reference": { "type": "PubMed", "id": "16150865", "url": "https://pubmed.ncbi.nlm.nih.gov/16150865" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P11474-1", "protein_name": "Steroid hormone receptor ERR1", "gene_name": "ESRRA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P11474", "url": "https://www.uniprot.org/uniprotkb/P11474" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 118, "end_pos": 118, "sequence_org": "S", "sequence_mut": "A", "comment": "Binds DNA as a monomer or as a dimer as for wild type. No effect on interaction with PPARGC1A.", "evidence": [ { "database": "UniProtKB", "id": "P11474", "url": "https://www.uniprot.org/uniprotkb/P11474" }, { "database": "PubMed", "id": "16150865", "url": "https://pubmed.ncbi.nlm.nih.gov/16150865" } ], "uniprot_canonical_ac": "P11474-1" }, { "start_pos": 124, "end_pos": 124, "sequence_org": "T", "sequence_mut": "A", "comment": "Binds DNA predominantly as a monomer. Loss of interaction with PPARGC1A.", "evidence": [ { "database": "UniProtKB", "id": "P11474", "url": "https://www.uniprot.org/uniprotkb/P11474" }, { "database": "PubMed", "id": "16150865", "url": "https://pubmed.ncbi.nlm.nih.gov/16150865" } ], "uniprot_canonical_ac": "P11474-1" } ], "record_id": "pubmed.16150865", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Phosphorylation-dependent sumoylation of estrogen-related receptor alpha1.", "journal": "Biochemistry", "date": "2007", "authors": "Vu EH, Kraus RJ, Mertz JE", "reference": { "type": "PubMed", "id": "17676930", "url": "https://pubmed.ncbi.nlm.nih.gov/17676930" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P11474-1", "protein_name": "Steroid hormone receptor ERR1", "gene_name": "ESRRA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P11474", "url": "https://www.uniprot.org/uniprotkb/P11474" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 14, "end_pos": 14, "sequence_org": "K", "sequence_mut": "R", "comment": "Some loss of sumoylation. Complete loss of sumoylation; when associated with R-403.", "evidence": [ { "database": "UniProtKB", "id": "P11474", "url": "https://www.uniprot.org/uniprotkb/P11474" }, { "database": "PubMed", "id": "17676930", "url": "https://pubmed.ncbi.nlm.nih.gov/17676930" }, { "database": "PubMed", "id": "18063693", "url": "https://pubmed.ncbi.nlm.nih.gov/18063693" } ], "uniprot_canonical_ac": "P11474-1" }, { "start_pos": 19, "end_pos": 19, "sequence_org": "S", "sequence_mut": "A", "comment": "50% loss of phosphorylation but represses transactivation activity in the absence of coactivator. Almost complete loss of phosphorylation and 2-fold loss of repression of transactivation activity in response to coactivator; when associated with A-22.", "evidence": [ { "database": "UniProtKB", "id": "P11474", "url": "https://www.uniprot.org/uniprotkb/P11474" }, { "database": "PubMed", "id": "17676930", "url": "https://pubmed.ncbi.nlm.nih.gov/17676930" }, { "database": "PubMed", "id": "18063693", "url": "https://pubmed.ncbi.nlm.nih.gov/18063693" } ], "uniprot_canonical_ac": "P11474-1" }, { "start_pos": 19, "end_pos": 19, "sequence_org": "S", "sequence_mut": "D", "comment": "Represses transactivation activity in response to coactivator as for wild type; when associated with D-22.", "evidence": [ { "database": "UniProtKB", "id": "P11474", "url": "https://www.uniprot.org/uniprotkb/P11474" }, { "database": "PubMed", "id": "17676930", "url": "https://pubmed.ncbi.nlm.nih.gov/17676930" }, { "database": "PubMed", "id": "18063693", "url": "https://pubmed.ncbi.nlm.nih.gov/18063693" } ], "uniprot_canonical_ac": "P11474-1" }, { "start_pos": 22, "end_pos": 22, "sequence_org": "S", "sequence_mut": "A", "comment": "15% loss of phosphorylation but little transactivating activity. Almost complete loss of phosphorylation and 2-fold loss of repression of transactivation activity in the presence of coactivator; when associated with A-19.", "evidence": [ { "database": "UniProtKB", "id": "P11474", "url": "https://www.uniprot.org/uniprotkb/P11474" }, { "database": "PubMed", "id": "17676930", "url": "https://pubmed.ncbi.nlm.nih.gov/17676930" }, { "database": "PubMed", "id": "18063693", "url": "https://pubmed.ncbi.nlm.nih.gov/18063693" } ], "uniprot_canonical_ac": "P11474-1" }, { "start_pos": 22, "end_pos": 22, "sequence_org": "S", "sequence_mut": "D", "comment": "Represses transactivation activity in response to coactivator as for wild type; when associated with D-19.", "evidence": [ { "database": "UniProtKB", "id": "P11474", "url": "https://www.uniprot.org/uniprotkb/P11474" }, { "database": "PubMed", "id": "17676930", "url": "https://pubmed.ncbi.nlm.nih.gov/17676930" }, { "database": "PubMed", "id": "18063693", "url": "https://pubmed.ncbi.nlm.nih.gov/18063693" } ], "uniprot_canonical_ac": "P11474-1" }, { "start_pos": 403, "end_pos": 403, "sequence_org": "K", "sequence_mut": "R", "comment": "Decrease in sumoylation. No effect on transcriptional activity. Complete loss of sumoylation; when associated with R-14.", "evidence": [ { "database": "UniProtKB", "id": "P11474", "url": "https://www.uniprot.org/uniprotkb/P11474" }, { "database": "PubMed", "id": "17676930", "url": "https://pubmed.ncbi.nlm.nih.gov/17676930" }, { "database": "PubMed", "id": "18063693", "url": "https://pubmed.ncbi.nlm.nih.gov/18063693" } ], "uniprot_canonical_ac": "P11474-1" }, { "start_pos": 413, "end_pos": 413, "sequence_org": "L", "sequence_mut": "A", "comment": "Loss of coactivation activity; when associated with A-418. Loss of increased response to coactivator; when associated with A-19 and A-418.", "evidence": [ { "database": "UniProtKB", "id": "P11474", "url": "https://www.uniprot.org/uniprotkb/P11474" }, { "database": "PubMed", "id": "17676930", "url": "https://pubmed.ncbi.nlm.nih.gov/17676930" } ], "uniprot_canonical_ac": "P11474-1" }, { "start_pos": 418, "end_pos": 418, "sequence_org": "L", "sequence_mut": "A", "comment": "Loss of coactivation activity; when associated with A-413. 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