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"date": "2008", "authors": "Vanhatupa S, Ungureanu D, Paakkunainen M, Silvennoinen O", "reference": { "type": "PubMed", "id": "17897103", "url": "https://pubmed.ncbi.nlm.nih.gov/17897103" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P42224-1", "protein_name": "Signal transducer and activator of transcription 1-alpha/beta", "gene_name": "STAT1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P42224", "url": "https://www.uniprot.org/uniprotkb/P42224" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 701, "end_pos": 701, "sequence_org": "Y", "sequence_mut": "E", "comment": "Not phosphorylated at S-708 upon IFNB induction.", "evidence": [ { "database": "UniProtKB", "id": "P42224", "url": "https://www.uniprot.org/uniprotkb/P42224" }, { "database": "PubMed", "id": "22065572", "url": 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Enhances sumoylation in the presence of MAPK stimulation. Phosphorylated at S-708 upon IFNB induction.", "evidence": [ { "database": "UniProtKB", "id": "P42224", "url": "https://www.uniprot.org/uniprotkb/P42224" }, { "database": "PubMed", "id": "22065572", "url": "https://pubmed.ncbi.nlm.nih.gov/22065572" }, { "database": "PubMed", "id": "17897103", "url": "https://pubmed.ncbi.nlm.nih.gov/17897103" } ], "uniprot_canonical_ac": "P42224-1" }, { "start_pos": 727, "end_pos": 727, "sequence_org": "S", "sequence_mut": "A", "comment": "Decreased transcriptional activation. No effect on basal sumoylation. No enhancement of sumoylation on MAPK stimulation. No PRKCD-induced apoptosis. Upon IFNB induction, phosphorylated at Y-701 but not at S-708. 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