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Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils.", "journal": "J. Clin. Invest.", "date": "1996", "authors": "Ponath P D, Qin S, Ringler D J, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo J A, Newman W, Gutierrez-Ramos J C, Mackay C R", "reference": { "type": "PubMed", "id": "8609214", "url": "https://pubmed.ncbi.nlm.nih.gov/8609214" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P51671-1", "protein_name": "Eotaxin", "gene_name": "CCL11", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P51671", "url": "https://www.uniprot.org/uniprotkb/P51671" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.8609214", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", 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Biophys. Res. Commun.", "date": "1996", "authors": "Bartels J, Schl\u00fcter C, Richter E, Noso N, Kulke R, Christophers E, Schr\u00f6der J M", "reference": { "type": "PubMed", "id": "8780731", "url": "https://pubmed.ncbi.nlm.nih.gov/8780731" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P51671-1", "protein_name": "Eotaxin", "gene_name": "CCL11", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P51671", "url": "https://www.uniprot.org/uniprotkb/P51671" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.8780731", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene.", "journal": "Biochem. 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E, Dickinson P J, Van Dyke J E, Woolard K D, Berens M E, Lesniak M S, Sturges B K, Vernau K M, Li C, Miska J, Toedebusch Christine M", "reference": { "type": "PubMed", "id": "39046599", "url": "https://pubmed.ncbi.nlm.nih.gov/39046599" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P51679-1", "protein_name": "C-C chemokine receptor type 4", "gene_name": "CCR4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P51679", "url": "https://www.uniprot.org/uniprotkb/P51679" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.39046599", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", 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Small loss of sulfation; when associated with F-10 and F-14.", "evidence": [ { "database": "UniProtKB", "id": "P51681", "url": "https://www.uniprot.org/uniprotkb/P51681" }, { "database": "PubMed", "id": "11733580", "url": "https://pubmed.ncbi.nlm.nih.gov/11733580" }, { "database": "PubMed", "id": "10089882", "url": "https://pubmed.ncbi.nlm.nih.gov/10089882" } ], "uniprot_canonical_ac": "P51681-1" }, { "start_pos": 3, "end_pos": 3, "sequence_org": "Y", "sequence_mut": "D", "comment": "No sulfation and strongly decreases binding with CCL4 and CCL5; when associated with D-10; D-14 and D-15. 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Disrupts conformational integrity. Disrupts binding of CCL4. Decreases HIV cell infection.", "evidence": [ { "database": "UniProtKB", "id": "P51681", "url": "https://www.uniprot.org/uniprotkb/P51681" }, { "database": "PubMed", "id": "10383387", "url": "https://pubmed.ncbi.nlm.nih.gov/10383387" } ], "uniprot_canonical_ac": "P51681-1" }, { "start_pos": 178, "end_pos": 178, "sequence_org": "C", "sequence_mut": "A", "comment": "Decreases to 40% surface expression. Disrupts conformational integrity. Disrupts binding of CCL4. Decreases HIV cell infection.", "evidence": [ { "database": "UniProtKB", "id": "P51681", "url": "https://www.uniprot.org/uniprotkb/P51681" }, { "database": "PubMed", "id": "10383387", "url": "https://pubmed.ncbi.nlm.nih.gov/10383387" } ], "uniprot_canonical_ac": "P51681-1" }, { "start_pos": 20, "end_pos": 20, "sequence_org": "C", "sequence_mut": "A", "comment": "Decreases to 40% surface expression. No effect on conformational integrity. Disrupts binding of CCL4. 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"count": 0 } ], "sort_fields": [] } ] }, { "title": "Novel variant of the CCR5 gene in a Vietnamese population.", "journal": "Microbes and infection", "date": "1999", "authors": "Magierowska M, Lepage V, Lien TX, Lan NT, Guillotel M, Issafras H, Reynes JM, Fleury HJ, Chi NH, Follezou JY, Debre P, Theodorou I, Barre-Sinoussi F", "reference": { "type": "PubMed", "id": "10917742", "url": "https://pubmed.ncbi.nlm.nih.gov/10917742" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P51681-1", "protein_name": "C-C chemokine receptor type 5", "gene_name": "CCR5", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P51681", "url": "https://www.uniprot.org/uniprotkb/P51681" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10917742", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": 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HIV entry reduced by 50%; when associated with A-321 and A-324.", "evidence": [ { "database": "UniProtKB", "id": "P51681", "url": "https://www.uniprot.org/uniprotkb/P51681" }, { "database": "PubMed", "id": "11323418", "url": "https://pubmed.ncbi.nlm.nih.gov/11323418" } ], "uniprot_canonical_ac": "P51681-1" }, { "start_pos": 324, "end_pos": 324, "sequence_org": "C", "sequence_mut": "A", "comment": "Small reduction in palmitoylation. Cell surface expression reduced by 50%. Greatly reduced palmitoylation. Cell surface expression greatly reduced; when associated with A-321 or A-323. No palmitoylation. Cell surface expression greatly reduced. 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "A homologous naturally occurring mutation in Duffy and CCR5 leading to reduced receptor expression.", "journal": "Blood", "date": "2001", "authors": "Tamasauskas D, Powell V, Saksela K, Yazdanbakhsh K", "reference": { "type": "PubMed", "id": "11369664", "url": "https://pubmed.ncbi.nlm.nih.gov/11369664" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P51681-1", "protein_name": "C-C chemokine receptor type 5", "gene_name": "CCR5", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P51681", "url": "https://www.uniprot.org/uniprotkb/P51681" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11369664", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], 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Med.", "date": "2006", "authors": "Glass William G, McDermott David H, Lim Jean K, Lekhong Sudkamon, Yu Shuk Fong, Frank William A, Pape John, Cheshier Ronald C, Murphy Philip M", "reference": { "type": "PubMed", "id": "16418398", "url": "https://pubmed.ncbi.nlm.nih.gov/16418398" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P51681-1", "protein_name": "C-C chemokine receptor type 5", "gene_name": "CCR5", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P51681", "url": "https://www.uniprot.org/uniprotkb/P51681" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.16418398", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ 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functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha.", "journal": "The Journal of biological chemistry", "date": "1996-07-19", "authors": "Raport C J, Gosling J, Schweickart V L, Gray P W, Charo I F", "reference": { "type": "PubMed", "id": "8663314", "url": "https://pubmed.ncbi.nlm.nih.gov/8663314" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P51681-1", "protein_name": "C-C chemokine receptor type 5", "gene_name": "CCR5", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P51681", "url": "https://www.uniprot.org/uniprotkb/P51681" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.8663314", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": 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"o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES.", "journal": "Journal of leukocyte biology", "date": "1996-07", "authors": "Combadiere C, Ahuja S K, Tiffany H L, Murphy P M", "reference": { "type": "PubMed", "id": "8699119", "url": "https://pubmed.ncbi.nlm.nih.gov/8699119" }, 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}, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene.", "journal": "Nature", "date": "1996", "authors": "Samson M, Libert F, Doranz B J, Rucker J, Liesnard C, Farber C M, Saragosti S, Lapoumeroulie C, Cognaux J, Forceille C, Muyldermans G, Verhofstede C, Burtonboy G, Georges M, Imai T, Rana S, Yi Y, Smyth R J, Collman R G, Doms R W, Vassart G, Parmentier M", "reference": { "type": "PubMed", "id": "8751444", "url": "https://pubmed.ncbi.nlm.nih.gov/8751444" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P51681-1", "protein_name": "C-C chemokine receptor type 5", "gene_name": "CCR5", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P51681", "url": "https://www.uniprot.org/uniprotkb/P51681" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.8751444", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 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"Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection.", "journal": "Cell", "date": "1996", "authors": "Liu R, Paxton W A, Choe S, Ceradini D, Martin S R, Horuk R, MacDonald M E, Stuhlmann H, Koup R A, Landau N R", "reference": { "type": "PubMed", "id": "8756719", "url": "https://pubmed.ncbi.nlm.nih.gov/8756719" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P51681-1", "protein_name": "C-C chemokine receptor type 5", "gene_name": "CCR5", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P51681", "url": "https://www.uniprot.org/uniprotkb/P51681" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.8756719", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": 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"o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The extent of genetic variation in the CCR5 gene.", "journal": "Nature genetics", "date": "1997", "authors": "Ansari-Lari MA, Liu XM, Metzker ML, Rut AR, Gibbs RA", "reference": { "type": "PubMed", "id": "9207783", "url": "https://pubmed.ncbi.nlm.nih.gov/9207783" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P51681-1", "protein_name": "C-C 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