[
    {
        "title": "Negative regulation of the heat shock transcriptional response by HSBP1.",
        "journal": "Genes &amp; development",
        "date": "1998",
        "authors": "Satyal SH, Chen D, Fox SG, Kramer JM, Morimoto RI",
        "reference": {
            "type": "PubMed",
            "id": "9649501",
            "url": "https://pubmed.ncbi.nlm.nih.gov/9649501"
        },
        "referenced_glycans": [],
        "referenced_proteins": [
            {
                "uniprot_canonical_ac": "Q92793-1",
                "protein_name": "CREB-binding protein",
                "gene_name": "CREBBP",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q15185-1",
                "protein_name": "Prostaglandin E synthase 3",
                "gene_name": "PTGES3",
                "tax_name": "Human"
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                "uniprot_canonical_ac": "P25685-1",
                "protein_name": "DnaJ homolog subfamily B member 1",
                "gene_name": "DNAJB1",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P34931-1",
                "protein_name": "Heat shock 70 kDa protein 1-like",
                "gene_name": "HSPA1L",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P54652-1",
                "protein_name": "Heat shock-related 70 kDa protein 2",
                "gene_name": "HSPA2",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P08238-1",
                "protein_name": "Heat shock protein HSP 90-beta",
                "gene_name": "HSP90AB1",
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                "uniprot_canonical_ac": "P11142-1",
                "protein_name": "Heat shock cognate 71 kDa protein",
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                "uniprot_canonical_ac": "Q09472-1",
                "protein_name": "Histone acetyltransferase p300",
                "gene_name": "EP300",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P07900-1",
                "protein_name": "Heat shock protein HSP 90-alpha",
                "gene_name": "HSP90AA1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q02790-1",
                "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP4",
                "gene_name": "FKBP4",
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            },
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                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q00613-1",
                "protein_name": "Heat shock factor protein 1",
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            },
            {
                "uniprot_canonical_ac": "P0DMV9-1",
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            },
            {
                "uniprot_canonical_ac": "P0DMV8-1",
                "protein_name": "Heat shock 70 kDa protein 1A",
                "gene_name": "HSPA1A",
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            }
        ],
        "species": [
            {
                "name": "Homo sapiens",
                "taxid": 9606,
                "evidence": [
                    {
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                        "id": "Q92793",
                        "url": "https://www.uniprot.org/uniprotkb/Q92793"
                    }
                ],
                "common_name": "Human",
                "glygen_name": "Human",
                "reference_species": "Homo sapiens [9606]"
            }
        ],
        "mutagenesis": [
            {
                "start_pos": 16,
                "end_pos": 16,
                "sequence_org": "V",
                "sequence_mut": "K",
                "comment": "Loss of interaction with HSF1; in association with K-19.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "O75506",
                        "url": "https://www.uniprot.org/uniprotkb/O75506"
                    },
                    {
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                ],
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            },
            {
                "start_pos": 19,
                "end_pos": 19,
                "sequence_org": "L",
                "sequence_mut": "K",
                "comment": "Loss of interaction with HSF1; in association with K-16.",
                "evidence": [
                    {
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                        "id": "O75506",
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                "start_pos": 45,
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                "sequence_org": "I",
                "sequence_mut": "K",
                "comment": "Loss of interaction with HSF1; in association with K-48.",
                "evidence": [
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                        "database": "UniProtKB",
                        "id": "O75506",
                        "url": "https://www.uniprot.org/uniprotkb/O75506"
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            {
                "start_pos": 48,
                "end_pos": 48,
                "sequence_org": "L",
                "sequence_mut": "K",
                "comment": "Loss of interaction with HSF1; in association with K-45.",
                "evidence": [
                    {
                        "database": "UniProtKB",
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        "abstract": "",
        "glycosylation": [],
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    {
        "title": "Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos.",
        "journal": "Current biology : CB",
        "date": "1998",
        "authors": "Lecourtois M, Schweisguth F",
        "reference": {
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                "uniprot_canonical_ac": "Q8NFT8-1",
                "protein_name": "Delta and Notch-like epidermal growth factor-related receptor",
                "gene_name": "DNER",
                "tax_name": "Human"
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                "uniprot_canonical_ac": "Q9NR61-1",
                "protein_name": "Delta-like protein 4",
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        "title": "A role for Groucho tetramerization in transcriptional repression.",
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    {
        "title": "Delta-1 activation of notch-1 signaling results in HES-1 transactivation.",
        "journal": "Molecular and cellular biology",
        "date": "1998",
        "authors": "Jarriault S, Le Bail O, Hirsinger E, Pourquie O, Logeat F, Strong CF, Brou C, Seidah NG, Isra l A",
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        "title": "Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids.",
        "journal": "The Journal of biological chemistry",
        "date": "2000",
        "authors": "Kojima Y, Fukumoto S, Furukawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, Ohta M, Furukawa K",
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        "title": "Expression cloning of human globoside synthase cDNAs. Identification of beta 3Gal-T3 as UDP-N-acetylgalactosamine:globotriaosylceramide beta 1,3-N-acetylgalactosaminyltransferase.",
        "journal": "The Journal of biological chemistry",
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        "authors": "Okajima T, Nakamura Y, Uchikawa M, Haslam DB, Numata SI, Furukawa K, Urano T, Furukawa K",
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    {
        "title": "Alteration of ganglioside biosynthesis responsible for complex hereditary spastic paraplegia.",
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        "authors": "Boukhris A, Schule R, Loureiro JL, Lourenco CM, Mundwiller E, Gonzalez MA, Charles P, Gauthier J, Rekik I, Acosta Lebrigio RF, Gaussen M, Speziani F, Ferbert A, Feki I, Caballero-Oteyza A, Dionne-Laporte A, Amri M, Noreau A, Forlani S, Cruz VT, Mochel F, Coutinho P, Dion P, Mhiri C, Schols L, Pouget J, Darios F, Rouleau GA, Marques W Jr, Brice A, Durr A, Zuchner S, Stevanin G",
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                                "id": "MONDO:0012213",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012213",
                                "name": "hereditary spastic paraplegia 26",
                                "description": "A rare, complex type of hereditary spastic paraplegia characterized by the onset in childhood/adolescence (ages 2-19) of progressive spastic paraplegia associated mainly with mild to moderate cognitive impairment and developmental delay, cerebellar ataxia, dysarthria, and peripheral neuropathy. Less commonly reported manifestations include skeletal abnormalities (i.e. pes cavus, scoliosis), dyskinesia, dystonia, cataracts, cerebellar signs (i.e. saccadic dysfunction, nystagmus, dysmetria), bladder disturbances, and behavioral problems. SPG26 is caused by mutations in the B4GALNT1 gene (12q13.3), encoding Beta-1, 4 N-acetylgalactosaminyltransferase 1."
                            },
                            {
                                "id": "MONDO:0012213",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012213",
                                "name": "GM2 synthase deficiency",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012213",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012213",
                                "name": "SPG26",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012213",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012213",
                                "name": "autosomal recessive spastic paraplegia type 26",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012213",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012213",
                                "name": "hereditary spastic paraplegia type 26",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012213",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012213",
                                "name": "spastic paraplegia 26",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012213",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012213",
                                "name": "spastic paraplegia 26, autosomal recessive",
                                "description": ""
                            },
                            {
                                "id": "MIM:609195",
                                "resource": "MIM",
                                "url": "https://www.omim.org/entry/609195",
                                "name": "Spastic paraplegia 26, autosomal recessive",
                                "description": "Spastic paraplegia 26, autosomal recessive"
                            }
                        ],
                        "unlinked_id_list": [],
                        "evidence": [
                            {
                                "id": "0012213",
                                "database": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012213"
                            },
                            {
                                "id": "609195",
                                "database": "MIM",
                                "url": "https://www.omim.org/entry/609195"
                            },
                            {
                                "id": "B4GALNT1",
                                "database": "Genomics England",
                                "url": "https://panelapp.genomicsengland.co.uk/panels/25/gene/B4GALNT1/#!details"
                            },
                            {
                                "id": "0110777",
                                "database": "AGR",
                                "url": "https://www.alliancegenome.org/disease/DOID:0110777"
                            }
                        ]
                    }
                ],
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                    {
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                ],
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        ]
    },
    {
        "title": "\u03b24GalT6 is involved in the synthesis of lactosylceramide with less intensity than \u03b24GalT5.",
        "journal": "Glycobiology",
        "date": "2013-10",
        "authors": "Tokuda Noriyo, Numata Shinichiro, Li Xiaojin, Nomura Tomoko, Takizawa Minoru, Kondo Yuji, Yamashita Yoriko, Hashimoto Noboru, Kiyono Tohru, Urano Takeshi, Furukawa Keiko, Furukawa Koichi",
        "reference": {
            "type": "PubMed",
            "id": "23882130",
            "url": "https://pubmed.ncbi.nlm.nih.gov/23882130"
        },
        "referenced_glycans": [],
        "referenced_proteins": [
            {
                "uniprot_canonical_ac": "O15466-1",
                "protein_name": "Alpha-2,8-sialyltransferase 8E",
                "gene_name": "ST8SIA5",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q16842-1",
                "protein_name": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2",
                "gene_name": "ST3GAL2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9UNP4-1",
                "protein_name": "Lactosylceramide alpha-2,3-sialyltransferase",
                "gene_name": "ST3GAL5",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O75752-1",
                "protein_name": "UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1",
                "gene_name": "B3GALNT1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9BVH7-1",
                "protein_name": "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5",
                "gene_name": "ST6GALNAC5",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q11203-1",
                "protein_name": "CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase",
                "gene_name": "ST3GAL3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q969X2-1",
                "protein_name": "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6",
                "gene_name": "ST6GALNAC6",
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            },
            {
                "uniprot_canonical_ac": "O43286-1",
                "protein_name": "Beta-1,4-galactosyltransferase 5",
                "gene_name": "B4GALT5",
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            },
            {
                "uniprot_canonical_ac": "Q16880-1",
                "protein_name": "2-hydroxyacylsphingosine 1-beta-galactosyltransferase",
                "gene_name": "UGT8",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q16739-1",
                "protein_name": "Ceramide glucosyltransferase",
                "gene_name": "UGCG",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "Q8TCT0-1",
                "protein_name": "Ceramide kinase",
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            },
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                "uniprot_canonical_ac": "Q9JMK0-1",
                "protein_name": "Beta-1,4-galactosyltransferase 5",
                "gene_name": "B4galt5",
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            },
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                "uniprot_canonical_ac": "Q9WVK5-1",
                "protein_name": "Beta-1,4-galactosyltransferase 6",
                "gene_name": "B4galt6",
                "tax_name": "Mouse"
            },
            {
                "uniprot_canonical_ac": "Q99999-1",
                "protein_name": "Galactosylceramide sulfotransferase",
                "gene_name": "GAL3ST1",
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            },
            {
                "uniprot_canonical_ac": "P19526-1",
                "protein_name": "Galactoside alpha-(1,2)-fucosyltransferase 1",
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            },
            {
                "uniprot_canonical_ac": "Q10981-1",
                "protein_name": "Galactoside alpha-(1,2)-fucosyltransferase 2",
                "gene_name": "FUT2",
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            },
            {
                "uniprot_canonical_ac": "O96024-1",
                "protein_name": "Beta-1,3-galactosyltransferase 4",
                "gene_name": "B3GALT4",
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            }
        ],
        "species": [
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                "name": "Homo sapiens",
                "taxid": 9606,
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                        "id": "O15466",
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                ],
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    },
    {
        "title": "Establishment of HeLa cell mutants deficient in sphingolipid-related genes using TALENs.",
        "journal": "PloS one",
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        "authors": "Yamaji T, Hanada K",
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            "url": "https://pubmed.ncbi.nlm.nih.gov/24498430"
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                "taxid": 9606,
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                "glygen_name": "Human",
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        ],
        "record_id": "pubmed.34982351",
        "abstract": "",
        "glycosylation": [],
        "mutagenesis": [],
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        "phosphorylation": [],
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        ]
    },
    {
        "title": "Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype.",
        "journal": "The Journal of biological chemistry",
        "date": "1995",
        "authors": "Kelly RJ, Rouquier S, Giorgi D, Lennon GG, Lowe JB",
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            {
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            {
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                "uniprot_canonical_ac": "O43825-1",
                "protein_name": "Beta-1,3-galactosyltransferase 2",
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            },
            {
                "uniprot_canonical_ac": "Q9Y2C3-1",
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            {
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            {
                "uniprot_canonical_ac": "Q16739-1",
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            {
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            {
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                            {
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                            {
                                "id": "MONDO:0016419",
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                            {
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                            },
                            {
                                "id": "MONDO:0016419",
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                                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
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                            {
                                "id": "MONDO:0016419",
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                            {
                                "id": "MONDO:0016419",
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                            {
                                "id": "MONDO:0016419",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
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                            },
                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
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                            {
                                "id": "MONDO:0007576",
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                            {
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                            {
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                            {
                                "id": "MONDO:0007576",
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                            {
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                            {
                                "id": "MONDO:0007576",
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                            {
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                                "resource": "MONDO",
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                                "description": ""
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                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
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                                "description": ""
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                            {
                                "id": "MONDO:0007576",
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                                "description": ""
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                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
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                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
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                                "description": ""
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                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
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                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
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                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
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                            {
                                "id": "MONDO:0007576",
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                            }
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    {
        "title": "Substrate specificity of beta 1,4-N-acetylgalactosaminyltransferase in vitro and in cDNA-transfected cells. GM2/GD2 synthase efficiently generates asialo-GM2 in certain cells.",
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        "title": "Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase.",
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        "title": "Cloning, characterization, and expression of human ceramide galactosyltransferase cDNA.",
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