[ { "title": "TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.", "journal": "Cell", "date": "2024-08-08", "authors": "Wang Haofeng, Liu Xiaoce, Zhang Xiang, Zhao Zhuoqian, Lu Yuchi, Pu Dingzhe, Zhang Zeyang, Chen Jie, Wang Yajie, Li Mengfei, Dong Xuxue, Duan Yinkai, He Yujia, Mao Qiyu, Guo Hangtian, Sun Haoran, Zhou Yihan, Yang Qi, Gao Yan, Yang Xiuna, Cao Hongzhi, Guddat Luke, Sun Lei, Rao Zihe, Yang Haitao", "reference": { "type": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15393-1", "protein_name": "Transmembrane protease serine 2", "gene_name": "TMPRSS2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 414, "end_pos": 414, "sequence_org": "Y", "sequence_mut": "A", "comment": "No effect on catalytic activity. Almost abolishes S protein-binding and HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 414, "end_pos": 414, "sequence_org": "Y", "sequence_mut": "L", "comment": "No effect on catalytic activity. Almost abolishes S protein-binding and HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 414, "end_pos": 414, "sequence_org": "Y", "sequence_mut": "R", "comment": "No effect on catalytic activity. Almost abolishes S protein-binding and HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 414, "end_pos": 414, "sequence_org": "Y", "sequence_mut": "S", "comment": "No effect on catalytic activity. Almost abolishes S protein-binding and HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 441, "end_pos": 441, "sequence_org": "S", "sequence_mut": "A", "comment": "Loss of activity. No effect on HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "11245484", "url": "https://pubmed.ncbi.nlm.nih.gov/11245484" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 469, "end_pos": 469, "sequence_org": "Y", "sequence_mut": "A", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 469, "end_pos": 469, "sequence_org": "Y", "sequence_mut": "L", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 469, "end_pos": 469, "sequence_org": "Y", "sequence_mut": "N", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 470, "end_pos": 470, "sequence_org": "R", "sequence_mut": "A", "comment": "No effect on catalytic activity. Abolishes HKU1-CoVS protein-binding and viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 470, "end_pos": 470, "sequence_org": "R", "sequence_mut": "K", "comment": "No effect on catalytic activity. 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U.S.A.", "date": "1998", "authors": "Kwon Y T, Reiss Y, Fried V A, Hershko A, Yoon J K, Gonda D K, Sangan P, Copeland N G, Jenkins N A, Varshavsky A", "reference": { "type": "PubMed", "id": "9653112", "url": "https://pubmed.ncbi.nlm.nih.gov/9653112" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8IWV7-1", "protein_name": "E3 ubiquitin-protein ligase UBR1", "gene_name": "UBR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O70481-1", "protein_name": "E3 ubiquitin-protein ligase UBR1", "gene_name": "Ubr1", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8IWV7", "url": "https://www.uniprot.org/uniprotkb/Q8IWV7" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9653112", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { 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"authors": "Ikeda Osamu, Miyasaka Yuto, Yoshida Ryuji, Mizushima Akihiro, Oritani Kenji, Sekine Yuichi, Kuroda Makoto, Yasui Teruhito, Fujimuro Masahiro, Muromoto Ryuta, Nanbo Asuka, Matsuda Tadashi", "reference": { "type": "PubMed", "id": "20138174", "url": "https://pubmed.ncbi.nlm.nih.gov/20138174" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q15326-1", "protein_name": "Zinc finger MYND domain-containing protein 11", "gene_name": "ZMYND11", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q15326", "url": "https://www.uniprot.org/uniprotkb/Q15326" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.20138174", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": 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"count": 0 } ], "sort_fields": [] } ] }, { "title": "MicroRNA-196b promotes cell growth and metastasis of ovarian cancer by targeting ZMYND11.", "journal": "Minerva medica", "date": "2022-08", "authors": "Zhang Zhiling, Xu Ling, Hu Zheng, Yang Baohua, Xu Jun", "reference": { "type": "PubMed", "id": "32512976", "url": "https://pubmed.ncbi.nlm.nih.gov/32512976" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q15326-1", "protein_name": "Zinc finger MYND domain-containing protein 11", "gene_name": "ZMYND11", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q15326", "url": "https://www.uniprot.org/uniprotkb/Q15326" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.32512976", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { 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"field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "ZMYND11 variants are a novel cause of centrotemporal and generalised epilepsies with neurodevelopmental disorder.", "journal": "Clinical genetics", "date": "2021", "authors": "Oates S, Absoud M, Goyal S, Bayley S, Baulcomb J, Sims A, Riddett A, Allis K, Brasch-Andersen C, Balasubramanian M, Bai R, Callewaert B, Huffmeier U, Le Duc D, Radtke M, Korff C, Kennedy J, Low K, Moller RS, Nielsen JEK, Popp B, Quteineh L, Ronde G, Schonewolf-Greulich B, Shillington A, Taylor MR, Todd E, Torring PM, Tumer Z, Vasileiou G, Yates TM, Zweier C, Rosch R, Basson MA, Pal DK", "reference": { "type": "PubMed", "id": "34216016", "url": "https://pubmed.ncbi.nlm.nih.gov/34216016" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q15326-1", "protein_name": "Zinc finger MYND domain-containing protein 11", "gene_name": "ZMYND11", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q15326", "url": "https://www.uniprot.org/uniprotkb/Q15326" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.34216016", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", 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Variations in THOC2 mRNA Nuclear Export Factor.", "journal": "Frontiers in molecular neuroscience", "date": "2020", "authors": "Kumar Raman, Palmer Elizabeth, Gardner Alison E, Carroll Renee, Banka Siddharth, Abdelhadi Ola, Donnai Dian, Elgersma Ype, Curry Cynthia J, Gardham Alice, Suri Mohnish, Malla Rishikesh, Brady Lauren Ilana, Tarnopolsky Mark, Azmanov Dimitar N, Atkinson Vanessa, Black Michael, Baynam Gareth, Dreyer Lauren, Hayeems Robin Z, Marshall Christian R, Costain Gregory, Wessels Marja W, Baptista Julia, Drummond James, Leffler Melanie, Field Michael, Gecz Jozef", "reference": { "type": "PubMed", "id": "32116545", "url": "https://pubmed.ncbi.nlm.nih.gov/32116545" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NI27-1", "protein_name": "THO complex subunit 2", "gene_name": "THOC2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NI27", "url": 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