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Biol.", "date": "1987", "authors": "MacLeod AR, Talbot K, Smillie LB, Houlker C", "reference": { "type": "PubMed", "id": "3612796", "url": "https://pubmed.ncbi.nlm.nih.gov/3612796" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P67936-1", "protein_name": "Tropomyosin alpha-4 chain", "gene_name": "TPM4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P67936", "url": "https://www.uniprot.org/uniprotkb/P67936" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.3612796", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", 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J. 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Are sex discordant outcomes in COVID-19 related to sex hormones?", "journal": "Seminars in oncology", "date": "2020", "authors": "Strope JD, Chau CH, Figg WD", "reference": { "type": "PubMed", "id": "32660890", "url": "https://pubmed.ncbi.nlm.nih.gov/32660890" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15393-1", "protein_name": "Transmembrane protease serine 2", "gene_name": "TMPRSS2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "biomarkers": [ { "best_biomarker_role": [ "prognostic" ], "biomarker_canonical_id": "AN6310", "assessed_biomarker_entity": [ "Transmembrane protease serine 2" ], "biomarker_id": "AN6310-1", "biomarker": [ "increased TMPRSS2 level" ], "condition": { "id": "DOID:0080600", "recommended_name": { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0080600", "name": "COVID-19", "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a subtype of Betacoronavirus pandemicum." }, "name_list": [ "COVID-19", "2019 Novel Coronavirus (2019-nCoV)", "2019-nCoV infection", "COVID19", "SARS-CoV-2 infection", "2019 novel coronavirus infection", "coronavirus disease 2019", "severe acute respiratory syndrome coronavirus 2 infectious disease", "2019 novel coronavirus", "2019-nCoV", "SARS-CoV-2", "SARS-coronavirus 2", "beta-CoV", "beta-CoVs", "betacoronavirus", "severe acute respiratory syndrome coronavirus 2", "-CoV", "-CoVs", "-coronavirus" ], "id_list": [ "DOID:0080600", "MONDO:0100096" ] } } ], "record_id": "pubmed.32660890", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation.", "journal": "Nature chemical biology", "date": "2022-09", "authors": "Fraser Bryan J, Beldar Serap, Seitova Almagul, Hutchinson Ashley, Mannar Dhiraj, Li Yanjun, Kwon Daniel, Tan Ruiyan, Wilson Ryan P, Leopold Karoline, Subramaniam Sriram, Halabelian Levon, Arrowsmith Cheryl H, B\u00e9nard Fran\u00e7ois", "reference": { "type": "PubMed", "id": "35676539", "url": "https://pubmed.ncbi.nlm.nih.gov/35676539" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15393-1", "protein_name": "Transmembrane protease serine 2", "gene_name": "TMPRSS2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.35676539", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Association of ACE2 and TMPRSS2 genes variants with disease severity and most important biomarkers in COVID-19 patients in Bosnia and Herzegovina.", "journal": "Croatian medical journal", "date": "2024-06-13", "authors": "Meseld\u017ei\u0107 Neven, Prnjavorac Besim, Duji\u0107 Tanja, Malenica Maja, Glamo\u010dlija Una, Prnjavorac Lejla, Bedak Omer, Imamovi\u0107 Kadri\u0107 Selma, Marjanovi\u0107 Damir, Bego Tamer", "reference": { "type": "PubMed", "id": "38868968", "url": "https://pubmed.ncbi.nlm.nih.gov/38868968" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15393-1", "protein_name": "Transmembrane protease serine 2", "gene_name": "TMPRSS2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.38868968", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus.", "journal": "Cell", "date": "2024-08-08", "authors": "Fern\u00e1ndez Ignacio, Saunders Nell, Duquerroy St\u00e9phane, Bolland William H, Arbabian Atousa, Baquero Eduard, Blanc Catherine, Lafaye Pierre, Haouz Ahmed, Buchrieser Julian, Schwartz Olivier, Rey F\u00e9lix A", "reference": { "type": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15393-1", "protein_name": "Transmembrane protease serine 2", "gene_name": "TMPRSS2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": { "label": "iCn3D", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?bcifid=7XYD&bu=0&command=select+.B:213;+center+selection;+zoom+selection" }, "start_pos": 213, "start_aa": "Asn", "end_pos": 213, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn213", "evidence": [ { "id": "O15393", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O15393#ptm_processing" }, { "id": "37990007", "database": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/37990007" }, { "id": "7XYD", "database": "PDB", "url": "https://www.rcsb.org/sequence/7XYD" }, { "id": "7Y0E", "database": "PDB", "url": "https://www.rcsb.org/sequence/7Y0E" }, { "id": "38964326", "database": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "id": "8HD8", "database": "PDB", "url": "https://www.rcsb.org/sequence/8HD8" }, { "id": "8S0L", "database": "PDB", "url": "https://www.rcsb.org/sequence/8S0L" }, { "id": "7Y0F", "database": "PDB", "url": "https://www.rcsb.org/sequence/7Y0F" }, { "id": "8S0M", "database": "PDB", "url": "https://www.rcsb.org/sequence/8S0M" }, { "id": "8V04", "database": "PDB", "url": "https://www.rcsb.org/structure/8V04" }, { "id": "9JCX", "database": "PDB", "url": "https://www.rcsb.org/structure/9JCX" }, { "id": "9JD0", "database": "PDB", "url": "https://www.rcsb.org/structure/9JD0" }, { "id": "9OPQ", "database": "PDB", "url": "https://www.rcsb.org/structure/9OPQ" }, { "id": "9U8G", "database": "PDB", "url": "https://www.rcsb.org/structure/9U8G" } ], "filter_code": "001000000000000000000.00010000000000.00.01001", "uniprot_canonical_ac": "O15393-1" } ], "mutagenesis": [ { "start_pos": 255, "end_pos": 255, "sequence_org": "R", "sequence_mut": "Q", "comment": "Loss of cleavage. No effect on HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "11245484", "url": "https://pubmed.ncbi.nlm.nih.gov/11245484" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 316, "end_pos": 316, "sequence_org": "R", "sequence_mut": "A", "comment": "No effect on catalytic activity or HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 341, "end_pos": 341, "sequence_org": "T", "sequence_mut": "A", "comment": "No effect on catalytic activity or HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 341, "end_pos": 341, "sequence_org": "T", "sequence_mut": "S", "comment": "No effect on catalytic activity or HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 409, "end_pos": 409, "sequence_org": "R", "sequence_mut": "A", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 409, "end_pos": 409, "sequence_org": "R", "sequence_mut": "T", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 412, "end_pos": 412, "sequence_org": "S", "sequence_mut": "A", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 412, "end_pos": 412, "sequence_org": "S", "sequence_mut": "N", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 413, "end_pos": 413, "sequence_org": "R", "sequence_mut": "A", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 413, "end_pos": 413, "sequence_org": "R", "sequence_mut": "K", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 413, "end_pos": 413, "sequence_org": "R", "sequence_mut": "V", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 414, "end_pos": 414, "sequence_org": "Y", "sequence_mut": "A", "comment": "No effect on catalytic activity. Almost abolishes S protein-binding and HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 414, "end_pos": 414, "sequence_org": "Y", "sequence_mut": "L", "comment": "No effect on catalytic activity. Almost abolishes S protein-binding and HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 414, "end_pos": 414, "sequence_org": "Y", "sequence_mut": "R", "comment": "No effect on catalytic activity. Almost abolishes S protein-binding and HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 414, "end_pos": 414, "sequence_org": "Y", "sequence_mut": "S", "comment": "No effect on catalytic activity. Almost abolishes S protein-binding and HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 416, "end_pos": 416, "sequence_org": "Y", "sequence_mut": "A", "comment": "No effect on catalytic activity. Almost abolishes HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 417, "end_pos": 417, "sequence_org": "D", "sequence_mut": "A", "comment": "No effect on catalytic activity. Almost abolishes HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 417, "end_pos": 417, "sequence_org": "D", "sequence_mut": "N", "comment": "No effect on catalytic activity. Almost abolishes HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 419, "end_pos": 419, "sequence_org": "L", "sequence_mut": "A", "comment": "No effect on catalytic activity. Abolishes HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 419, "end_pos": 419, "sequence_org": "L", "sequence_mut": "M", "comment": "No effect on catalytic activity. Abolishes HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 419, "end_pos": 419, "sequence_org": "L", "sequence_mut": "R", "comment": "No effect on catalytic activity. Abolishes HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 430, "end_pos": 430, "sequence_org": "L", "sequence_mut": "R", "comment": "No effect on catalytic activity. Abolishes HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 431, "end_pos": 431, "sequence_org": "Q", "sequence_mut": "A", "comment": "No effect on catalytic activity or HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 433, "end_pos": 433, "sequence_org": "N", "sequence_mut": "A", "comment": "No effect on catalytic activity or HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 441, "end_pos": 441, "sequence_org": "S", "sequence_mut": "A", "comment": "Loss of activity. No effect on HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "11245484", "url": "https://pubmed.ncbi.nlm.nih.gov/11245484" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 461, "end_pos": 461, "sequence_org": "W", "sequence_mut": "A", "comment": "No effect on catalytic activity. Abolishes HKU1-CoVS protein-binding and viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 463, "end_pos": 463, "sequence_org": "S", "sequence_mut": "A", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 463, "end_pos": 463, "sequence_org": "S", "sequence_mut": "F", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 463, "end_pos": 463, "sequence_org": "S", "sequence_mut": "T", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 463, "end_pos": 463, "sequence_org": "S", "sequence_mut": "Y", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 467, "end_pos": 467, "sequence_org": "K", "sequence_mut": "A", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 469, "end_pos": 469, "sequence_org": "Y", "sequence_mut": "A", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 469, "end_pos": 469, "sequence_org": "Y", "sequence_mut": "L", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 469, "end_pos": 469, "sequence_org": "Y", "sequence_mut": "N", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 470, "end_pos": 470, "sequence_org": "R", "sequence_mut": "A", "comment": "No effect on catalytic activity. Abolishes HKU1-CoVS protein-binding and viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 470, "end_pos": 470, "sequence_org": "R", "sequence_mut": "K", "comment": "No effect on catalytic activity. Abolishes HKU1-CoVS protein-binding and viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" } ], "record_id": "pubmed.38964326", "abstract": "", "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "icn3d_view.label", "icn3d_view.url", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl", "filter_code", "uniprot_canonical_ac" ] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", 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0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Human coronavirus HKU1 recognition of the TMPRSS2 host receptor.", "journal": "Cell", "date": "2024-08-08", "authors": "McCallum Matthew, Park Young-Jun, Stewart Cameron, Sprouse Kaitlin R, Addetia Amin, Brown Jack, Tortorici M Alejandra, Gibson Cecily, Wong Emily, Ieven Margareta, Telenti Amalio, Veesler David", "reference": { "type": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15393-1", "protein_name": "Transmembrane protease serine 2", "gene_name": "TMPRSS2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 340, "end_pos": 340, "sequence_org": "K", "sequence_mut": "D", "comment": "No effect on HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 341, "end_pos": 341, "sequence_org": "T", "sequence_mut": "A", "comment": "No effect on catalytic activity or HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 341, "end_pos": 341, "sequence_org": "T", "sequence_mut": "S", "comment": "No effect on catalytic activity or HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 409, "end_pos": 409, "sequence_org": "R", "sequence_mut": "A", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 409, "end_pos": 409, "sequence_org": "R", "sequence_mut": "T", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 412, "end_pos": 412, "sequence_org": "S", "sequence_mut": "A", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 412, "end_pos": 412, "sequence_org": "S", "sequence_mut": "N", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 413, "end_pos": 413, "sequence_org": "R", "sequence_mut": "A", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 413, "end_pos": 413, "sequence_org": "R", "sequence_mut": "K", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 413, "end_pos": 413, "sequence_org": "R", "sequence_mut": "V", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 414, "end_pos": 414, "sequence_org": "Y", "sequence_mut": "A", "comment": "No effect on catalytic activity. Almost abolishes S protein-binding and HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 414, "end_pos": 414, "sequence_org": "Y", "sequence_mut": "L", "comment": "No effect on catalytic activity. Almost abolishes S protein-binding and HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 414, "end_pos": 414, "sequence_org": "Y", "sequence_mut": "R", "comment": "No effect on catalytic activity. Almost abolishes S protein-binding and HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 414, "end_pos": 414, "sequence_org": "Y", "sequence_mut": "S", "comment": "No effect on catalytic activity. Almost abolishes S protein-binding and HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 415, "end_pos": 415, "sequence_org": "V", "sequence_mut": "I", "comment": "No effect on HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 417, "end_pos": 417, "sequence_org": "D", "sequence_mut": "A", "comment": "No effect on catalytic activity. Almost abolishes HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 417, "end_pos": 417, "sequence_org": "D", "sequence_mut": "N", "comment": "No effect on catalytic activity. Almost abolishes HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 419, "end_pos": 419, "sequence_org": "L", "sequence_mut": "A", "comment": "No effect on catalytic activity. Abolishes HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 419, "end_pos": 419, "sequence_org": "L", "sequence_mut": "M", "comment": "No effect on catalytic activity. Abolishes HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 419, "end_pos": 419, "sequence_org": "L", "sequence_mut": "R", "comment": "No effect on catalytic activity. Abolishes HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 441, "end_pos": 441, "sequence_org": "S", "sequence_mut": "A", "comment": "Loss of activity. No effect on HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "11245484", "url": "https://pubmed.ncbi.nlm.nih.gov/11245484" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 461, "end_pos": 461, "sequence_org": "W", "sequence_mut": "A", "comment": "No effect on catalytic activity. Abolishes HKU1-CoVS protein-binding and viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 463, "end_pos": 463, "sequence_org": "S", "sequence_mut": "A", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 463, "end_pos": 463, "sequence_org": "S", "sequence_mut": "F", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 463, "end_pos": 463, "sequence_org": "S", "sequence_mut": "T", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 463, "end_pos": 463, "sequence_org": "S", "sequence_mut": "Y", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 468, "end_pos": 468, "sequence_org": "A", "sequence_mut": "P", "comment": "No effect on HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 469, "end_pos": 469, "sequence_org": "Y", "sequence_mut": "A", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 469, "end_pos": 469, "sequence_org": "Y", "sequence_mut": "L", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 469, "end_pos": 469, "sequence_org": "Y", "sequence_mut": "N", "comment": "No effect on catalytic activity. Reduces HKU1-CoV viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 470, "end_pos": 470, "sequence_org": "R", "sequence_mut": "A", "comment": "No effect on catalytic activity. Abolishes HKU1-CoVS protein-binding and viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" }, { "start_pos": 470, "end_pos": 470, "sequence_org": "R", "sequence_mut": "K", "comment": "No effect on catalytic activity. Abolishes HKU1-CoVS protein-binding and viral entry.", "evidence": [ { "database": "UniProtKB", "id": "O15393", "url": "https://www.uniprot.org/uniprotkb/O15393" }, { "database": "PubMed", "id": "38964326", "url": "https://pubmed.ncbi.nlm.nih.gov/38964326" }, { "database": "PubMed", "id": "38964328", "url": "https://pubmed.ncbi.nlm.nih.gov/38964328" }, { "database": "PubMed", "id": "38964329", "url": "https://pubmed.ncbi.nlm.nih.gov/38964329" } ], "uniprot_canonical_ac": "O15393-1" } ], "record_id": "pubmed.38964328", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] } ]