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        "title": "Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase.",
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        "title": "G protein-coupled estrogen receptor 1 (GPER1)/GPR30 increases ERK1/2 activity through PDZ motif-dependent and -independent mechanisms.",
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        "date": "2017",
        "authors": "Gonzalez de Valdivia E, Broselid S, Kahn R, Olde B, Leeb-Lundberg LMF",
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                "common_name": "Human",
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                "reference_species": "Homo sapiens [9606]"
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        "record_id": "pubmed.17409413",
        "abstract": "",
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                    {
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        ]
    },
    {
        "title": "Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase.",
        "journal": "Molecular and cellular biology",
        "date": "2007",
        "authors": "Jones N, Hardy WR, Friese MB, Jorgensen C, Smith MJ, Woody NM, Burden SJ, Pawson T",
        "reference": {
            "type": "PubMed",
            "id": "17452444",
            "url": "https://pubmed.ncbi.nlm.nih.gov/17452444"
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            {
                "uniprot_canonical_ac": "Q6S5L8-1",
                "protein_name": "SHC-transforming protein 4",
                "gene_name": "SHC4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q6S5L9-1",
                "protein_name": "SHC-transforming protein 4",
                "gene_name": "Shc4",
                "tax_name": "Mouse"
            }
        ],
        "species": [
            {
                "name": "Homo sapiens",
                "taxid": 9606,
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                    {
                        "database": "UniProtKB",
                        "id": "Q6S5L8",
                        "url": "https://www.uniprot.org/uniprotkb/Q6S5L8"
                    }
                ],
                "common_name": "Human",
                "glygen_name": "Human",
                "reference_species": "Homo sapiens [9606]"
            }
        ],
        "mutagenesis": [
            {
                "start_pos": 315,
                "end_pos": 315,
                "sequence_org": "R",
                "sequence_mut": "Q",
                "comment": "Phosphorylation is markedly decreased. Completely reduces the phosphorylation and interaction with MUSK; when associated with K-549.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q6S5L8",
                        "url": "https://www.uniprot.org/uniprotkb/Q6S5L8"
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                        "url": "https://pubmed.ncbi.nlm.nih.gov/17452444"
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                ],
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            },
            {
                "start_pos": 374,
                "end_pos": 375,
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                "comment": "Remains phosphorylated. Contains a residual phosphorylation; when associated with F-465. Retains the ability to bind MUSK. Reduced the phosphorylation in presence of MUSK; when associated with F-424 and F-465. Completely abolishes the phosphorylation in presence of MUSK; when associated with F-403; F-413; F-424 and F-465. Retains the ability to bind MUSK; when associated with F-465. Retains the ability to bind MUSK; when associated with F-424 and F-465. Retains the ability to bind MUSK; when associated with F-403; F-413; F-424 and F-465.",
                "evidence": [
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                        "database": "UniProtKB",
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            },
            {
                "start_pos": 403,
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                "comment": "Completely abolishes the phosphorylation in presence of MUSK; when associated with 374-F-F-375; F-413; F-424 and F-465.",
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                    {
                        "database": "UniProtKB",
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                ],
                "uniprot_canonical_ac": "Q6S5L8-1"
            },
            {
                "start_pos": 413,
                "end_pos": 413,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Completely abolishes the phosphorylation in presence of MUSK; when associated with 374-F-F-375; F-403; F-424 and F-465.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q6S5L8",
                        "url": "https://www.uniprot.org/uniprotkb/Q6S5L8"
                    },
                    {
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                        "id": "17452444",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/17452444"
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                ],
                "uniprot_canonical_ac": "Q6S5L8-1"
            },
            {
                "start_pos": 424,
                "end_pos": 424,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Significantly decreased GRB2 interaction. Reduced the phosphorylation in presence of MUSK; when associated with 374-F-F-375 and F-465. Completely abolishes the phosphorylation in presence of MUSK; when associated with 374-F-F-375; F-403; F-413 and F-465.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q6S5L8",
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                "comment": "Remains phosphorylated. Contains a residual phosphorylation; when associated with 374-F-F-375. Reduced the phosphorylation in presence of MUSK; when associated with 374-F-F-375 and 424. Completely abolishes the phosphorylation in presence of MUSK; when associated with 374-F-F-375; F-403; F-413 and F-424. Retains the ability to bind MUSK. Retains the ability to bind MUSK; when associated with 374-F-F-375. Retains the ability to bind MUSK; when associated with 374-F-F-375 and F-424. Retains the ability to bind MUSK; when associated with 374-F-F-375; F-403; F-413 and F-424.",
                "evidence": [
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                        "database": "UniProtKB",
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                ],
                "uniprot_canonical_ac": "Q6S5L8-1"
            },
            {
                "start_pos": 549,
                "end_pos": 549,
                "sequence_org": "R",
                "sequence_mut": "K",
                "comment": "Completely reduces the phosphorylation and interaction with MUSK; when associated with Q-315.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q6S5L8",
                        "url": "https://www.uniprot.org/uniprotkb/Q6S5L8"
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                "start_pos": 424,
                "end_pos": 424,
                "kinase_uniprot_canonical_ac": "",
                "kinase_gene_name": "",
                "residue": "Tyr",
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                    {
                        "database": "iPTMnet",
                        "id": "Q6S5L8",
                        "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6S5L8"
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                "site_lbl": "Tyr424",
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    {
        "title": "[ShcD interacts with TrkC through its PTB and SH2 domains].",
        "journal": "Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae",
        "date": "2009",
        "authors": "You YG, Li WQ, Yin B, Peng XZ",
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        ],
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        ],
        "record_id": "pubmed.20078941",
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        "title": "Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP.",
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        "date": "2007",
        "authors": "Liu S, Li P, Dybkov O, Nottrott S, Hartmuth K, Luhrmann R, Carlomagno T, Wahl MC",
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