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N-glycosylation site.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1989", "authors": "Gieselmann V, Polten A, Kreysing J, von Figura K", "reference": { "type": "PubMed", "id": "2574462", "url": "https://pubmed.ncbi.nlm.nih.gov/2574462" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P15289-1", "protein_name": "Arylsulfatase A", "gene_name": "ARSA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P15289", "url": "https://www.uniprot.org/uniprotkb/P15289" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.2574462", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ 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Irina, Timofeeva Alla, Emelyanov Anton, Trempe Jean-Fran\u00e7ois, Zakharova Ekaterina, Alcalay Roy N, Pchelina Sofya, Gan-Or Ziv", "reference": { "type": "PubMed", "id": "37381728", "url": "https://pubmed.ncbi.nlm.nih.gov/37381728" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P15289-1", "protein_name": "Arylsulfatase A", "gene_name": "ARSA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P15289", "url": "https://www.uniprot.org/uniprotkb/P15289" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.37381728", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] 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Commun.", "date": "1991", "authors": "Higuti T, Tsurumi C, Kawamura Y, Tsujita H, Osaka F, Yoshihara Y, Tani I, Tanaka K, Ichihara A", "reference": { "type": "PubMed", "id": "1830479", "url": "https://pubmed.ncbi.nlm.nih.gov/1830479" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P18859-1", "protein_name": "ATP synthase peripheral stalk subunit F6, mitochondrial", "gene_name": "ATP5PF", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P18859", "url": "https://www.uniprot.org/uniprotkb/P18859" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.1830479", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", 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], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death.", "journal": "Apoptosis : an international journal on programmed cell death", "date": "2012", "authors": "Oral O, Oz-Arslan D, Itah Z, Naghavi A, Deveci R, Karacali S, Gozuacik D", "reference": { "type": "PubMed", "id": "22644571", "url": "https://pubmed.ncbi.nlm.nih.gov/22644571" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9NT62-1", "protein_name": "Ubiquitin-like-conjugating enzyme ATG3", "gene_name": "ATG3", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NT62", "url": "https://www.uniprot.org/uniprotkb/Q9NT62" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.22644571", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 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"o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Binding to E1 and E3 is mutually exclusive for the human autophagy E2 Atg3.", "journal": "Protein science : a publication of the Protein Society", "date": "2013-12", "authors": "Qiu Yu, Hofmann Kay, Coats Julie E, Schulman Brenda A, Kaiser Stephen E", "reference": { "type": "PubMed", "id": "24186333", "url": "https://pubmed.ncbi.nlm.nih.gov/24186333" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9NT62-1", "protein_name": "Ubiquitin-like-conjugating enzyme ATG3", "gene_name": "ATG3", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NT62", "url": "https://www.uniprot.org/uniprotkb/Q9NT62" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.24186333", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "PTK2-mediated degradation of ATG3 impedes cancer cells susceptible to DNA damage treatment.", "journal": "Autophagy", "date": "2017", "authors": "Ma K, Fu W, Tang M, Zhang C, Hou T, Li R, Lu X, Wang Y, Zhou J, Li X, Zhang L, Wang L, Zhao Y, Zhu 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"table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Human ATG3 binding to lipid bilayers: role of lipid geometry, and electric charge.", "journal": "Scientific reports", "date": "2017", "authors": "Hervas JH, Landajuela A, Anton Z, Shnyrova AV, Goni FM, Alonso A", "reference": { "type": "PubMed", "id": "29142222", "url": "https://pubmed.ncbi.nlm.nih.gov/29142222" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9NT62-1", "protein_name": "Ubiquitin-like-conjugating enzyme ATG3", "gene_name": "ATG3", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NT62", "url": "https://www.uniprot.org/uniprotkb/Q9NT62" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 11, "end_pos": 11, "sequence_org": "K", "sequence_mut": "D", "comment": "Slightly decreases interaction with lipid monolayers; when associated with D-9. Slightly decreases insertion into lipid monolayers; when associated with D-9. Decreases affinity for monolayers containing cardiolipin (CL); when associated with D-9. Cancels selectivity for anionic phospholipids; when associated with D-11. Impairs binding to lipid bilayers; when associated with D-11. Impairs insertion into lipid bilayers; when associated with D-11. Does not induce vesicle tethering; when associated with D-11.", "evidence": [ { "database": "UniProtKB", "id": "Q9NT62", "url": "https://www.uniprot.org/uniprotkb/Q9NT62" }, { "database": "PubMed", "id": "29142222", "url": "https://pubmed.ncbi.nlm.nih.gov/29142222" } ], "uniprot_canonical_ac": "Q9NT62-1" }, { "start_pos": 9, "end_pos": 9, "sequence_org": "K", "sequence_mut": "D", "comment": "Slightly decreases interaction with lipid monolayers; when associated with D-11. Slightly decreases insertion into lipid monolayers; when associated with D-11. Decreases affinity for monolayers containing cardiolipin (CL); when associated with D-11. Cancels selectivity for anionic phospholipids; when associated with D-11. Impairs binding to lipid bilayers; when associated with D-11. Impairs insertion into lipid bilayers; when associated with D-11. Does not induce vesicle tethering; when associated with D-11.", "evidence": [ { "database": "UniProtKB", "id": "Q9NT62", "url": "https://www.uniprot.org/uniprotkb/Q9NT62" }, { "database": "PubMed", "id": "29142222", "url": "https://pubmed.ncbi.nlm.nih.gov/29142222" } ], "uniprot_canonical_ac": "Q9NT62-1" } ], "record_id": "pubmed.29142222", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "An N-terminal conserved region in human Atg3 couples membrane curvature sensitivity to conjugase activity during autophagy.", "journal": "Nature communications", "date": "2021", "authors": "Ye Y, Tyndall ER, Bui V, Tang Z, Shen Y, Jiang X, Flanagan JM, Wang HG, Tian F", "reference": { "type": "PubMed", "id": "33446636", "url": "https://pubmed.ncbi.nlm.nih.gov/33446636" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9NT62-1", "protein_name": "Ubiquitin-like-conjugating enzyme ATG3", "gene_name": "ATG3", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NT62", "url": "https://www.uniprot.org/uniprotkb/Q9NT62" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 15, "end_pos": 15, "sequence_org": "V", "sequence_mut": "K", "comment": "Significantly reduces ATG8-family conjugating enzyme activity; when associated with D-8. Decreases protein membrane interactions; when associated with D-8. Does not affect formation of the covalent thioester intermediate with MAP1LC3B; when associated with D-8.", "evidence": [ { "database": "UniProtKB", "id": "Q9NT62", "url": "https://www.uniprot.org/uniprotkb/Q9NT62" }, { "database": "PubMed", "id": "33446636", "url": "https://pubmed.ncbi.nlm.nih.gov/33446636" } ], "uniprot_canonical_ac": "Q9NT62-1" }, { "start_pos": 21, "end_pos": 21, "sequence_org": "P", "sequence_mut": "A", "comment": "Impairs ATG8-family conjugating enzyme activity. Does not affect protein membrane interactions. Does not affect formation of the covalent thioester intermediate with MAP1LC3B. Partially rescues MAP1LC3B lipidation in cell lacking ATG3.", "evidence": [ { "database": "UniProtKB", "id": "Q9NT62", "url": "https://www.uniprot.org/uniprotkb/Q9NT62" }, { "database": "PubMed", "id": "33446636", "url": "https://pubmed.ncbi.nlm.nih.gov/33446636" } ], "uniprot_canonical_ac": "Q9NT62-1" }, { "start_pos": 23, "end_pos": 23, "sequence_org": "L", "sequence_mut": "T", "comment": "Severely reduces ATG8-family conjugating enzyme activity. Reduces of about 40% protein membrane interactions. Does not affect formation of the covalent thioester intermediate with MAP1LC3B. 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Immunol.", "date": "1993", "authors": "Turman M A, Yabe T, McSherry C, Bach F H, Houchins J P", "reference": { "type": "PubMed", "id": "8458737", "url": "https://pubmed.ncbi.nlm.nih.gov/8458737" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16617-1", "protein_name": "Protein NKG7", "gene_name": "NKG7", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16617", "url": "https://www.uniprot.org/uniprotkb/Q16617" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.8458737", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition.", "journal": "Proc. 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