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Lower sensitivity to BTRC-triggered degradation, impaired phosphorylation by GSK3B and loss of cytoplasmic localization; when associated with A-96; A-100; A-107; A-111 and A-119.", "evidence": [ { "database": "UniProtKB", "id": "O95863", "url": "https://www.uniprot.org/uniprotkb/O95863" }, { "database": "PubMed", "id": "15448698", "url": "https://pubmed.ncbi.nlm.nih.gov/15448698" }, { "database": "PubMed", "id": "29059170", "url": "https://pubmed.ncbi.nlm.nih.gov/29059170" }, { "database": "PubMed", "id": "25827072", "url": "https://pubmed.ncbi.nlm.nih.gov/25827072" } ], "uniprot_canonical_ac": "O95863-1" }, { "start_pos": 119, "end_pos": 119, "sequence_org": "S", "sequence_mut": "E", "comment": "Predominantly localized to the cytoplasm; when associated with E-107; E-111 and E-115.", "evidence": [ { "database": "UniProtKB", "id": "O95863", "url": "https://www.uniprot.org/uniprotkb/O95863" }, { "database": "PubMed", "id": "15448698", "url": "https://pubmed.ncbi.nlm.nih.gov/15448698" }, { "database": "PubMed", "id": "29059170", "url": "https://pubmed.ncbi.nlm.nih.gov/29059170" }, { "database": "PubMed", "id": "25827072", "url": "https://pubmed.ncbi.nlm.nih.gov/25827072" } ], "uniprot_canonical_ac": "O95863-1" }, { "start_pos": 96, "end_pos": 96, "sequence_org": "S", "sequence_mut": "A", "comment": "Abolishes recognition and ubiquitination by BTRC which increases steady state level and half-life. Preferentially localizes to the nucleus. Induces a more aggressive tissue invasion program. Lower sensitivity to BTRC-triggered degradation, impairs phosphorylation by GSK3B and does not affect NOTCH1-induced degradation; when associated with A-100. Lower sensitivity to BTRC-triggered degradation, impaired phosphorylation by GSK3B and loss of cytoplasmic localization; when associated with A-100; A-107; A-111; A-115 and A-119.", "evidence": [ { "database": "UniProtKB", "id": "O95863", "url": "https://www.uniprot.org/uniprotkb/O95863" }, { "database": "PubMed", "id": "15448698", "url": "https://pubmed.ncbi.nlm.nih.gov/15448698" }, { "database": "PubMed", "id": "20305697", "url": "https://pubmed.ncbi.nlm.nih.gov/20305697" }, { "database": "PubMed", "id": "22128911", "url": "https://pubmed.ncbi.nlm.nih.gov/22128911" }, { "database": "PubMed", "id": "15647282", "url": "https://pubmed.ncbi.nlm.nih.gov/15647282" }, { "database": "PubMed", "id": "29059170", "url": "https://pubmed.ncbi.nlm.nih.gov/29059170" }, { "database": "PubMed", "id": "25827072", "url": "https://pubmed.ncbi.nlm.nih.gov/25827072" } ], "uniprot_canonical_ac": "O95863-1" } ], "record_id": "pubmed.25827072", "abstract": "", "glycosylation": [], "snv": [], 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Andr\u00e9 Van Helvoort, Da Cruz Marcelo Cavalcanti, Teixeira Silvia Aparecida, Reis Rui Manuel, Lopes Luiz Fernando, Pinto Mariana Tomazini", "reference": { "type": "PubMed", "id": "39392037", "url": "https://pubmed.ncbi.nlm.nih.gov/39392037" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43623-1", "protein_name": "Zinc finger protein SNAI2", "gene_name": "SNAI2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43623", "url": "https://www.uniprot.org/uniprotkb/O43623" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.39392037", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", 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[] } ] }, { "title": "Phosphorylation of the PCNA binding domain of the large subunit of replication factor C on Thr506 by cyclin-dependent kinases regulates binding to PCNA.", "journal": "Nucleic acids research", "date": "2003", "authors": "Salles-Passador I, Munshi A, Cannella D, Pennaneach V, Koundrioukoff S, Jaquinod M, Forest E, Podust V, Fotedar A, Fotedar R", "reference": { "type": "PubMed", "id": "12930972", "url": "https://pubmed.ncbi.nlm.nih.gov/12930972" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P35251-1", "protein_name": "Replication factor C subunit 1", "gene_name": "RFC1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P35251", "url": "https://www.uniprot.org/uniprotkb/P35251" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "phosphorylation": [ { "start_pos": 506, "end_pos": 506, 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Genet.", "date": "2019", "authors": "Cortese A, Simone R, Sullivan R, Vandrovcova J, Tariq H, Yau WY, Humphrey J, Jaunmuktane Z, Sivakumar P, Polke J, Ilyas M, Tribollet E, Tomaselli PJ, Devigili G, Callegari I, Versino M, Salpietro V, Efthymiou S, Kaski D, Wood NW, Andrade NS, Buglo E, Rebelo A, Rossor AM, Bronstein A, Fratta P, Marques WJ, Zuchner S, Reilly MM, Houlden H", "reference": { "type": "PubMed", "id": "30926972", "url": "https://pubmed.ncbi.nlm.nih.gov/30926972" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P35251-1", "protein_name": "Replication factor C subunit 1", "gene_name": "RFC1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P35251", "url": "https://www.uniprot.org/uniprotkb/P35251" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.30926972", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Bioinformatics-Based Identification of Expanded Repeats: A Non-reference Intronic Pentamer Expansion in RFC1 Causes CANVAS.", "journal": "Am. 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"journal": "Journal of neurology", "date": "2024-09", "authors": "Schaub Annalisa, Erdmann Hannes, Scholz Veronika, Timmer Manuela, Cordts Isabell, G\u00fcnther Rene, Reilich Peter, Abicht Angela, Sch\u00f6berl Florian", "reference": { "type": "PubMed", "id": "38916676", "url": "https://pubmed.ncbi.nlm.nih.gov/38916676" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P35251-1", "protein_name": "Replication factor C subunit 1", "gene_name": "RFC1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P35251", "url": "https://www.uniprot.org/uniprotkb/P35251" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.38916676", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": 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Commun.", "date": "1993", "authors": "Lu Y, Zeft AS, Riegel AT", "reference": { "type": "PubMed", "id": "8512577", "url": "https://pubmed.ncbi.nlm.nih.gov/8512577" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P35251-1", "protein_name": "Replication factor C subunit 1", "gene_name": "RFC1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P35251", "url": "https://www.uniprot.org/uniprotkb/P35251" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.8512577", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ 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[] } ] }, { "title": "Expression of the relaxin family peptide 4 receptor by enterochromaffin cells of the mouse large intestine.", "journal": "Cell and tissue research", "date": "2022", "authors": "Koo A, Pustovit RV, Woodward ORM, Lewis JE, Gribble FM, Hossain MA, Reimann F, Furness JB", "reference": { "type": "PubMed", "id": "35596811", "url": "https://pubmed.ncbi.nlm.nih.gov/35596811" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8TDU9-1", "protein_name": "Relaxin-3 receptor 2", "gene_name": "RXFP4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8TDU9", "url": "https://www.uniprot.org/uniprotkb/Q8TDU9" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.35596811", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { 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