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                "protein_name": "Soluble guanylate cyclase 89Db",
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            {
                "name": "Drosophila melanogaster",
                "taxid": 7227,
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                        "id": "Q9VEU6",
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            }
        ],
        "record_id": "pubmed.15485853",
        "abstract": "",
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    {
        "title": "Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila.",
        "journal": "Cell",
        "date": "1999-06-25",
        "authors": "Hing H, Xiao J, Harden N, Lim L, Zipursky S L",
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            "id": "10399914",
            "url": "https://pubmed.ncbi.nlm.nih.gov/10399914"
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                "gene_name": "Pak",
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            },
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                "protein_name": "SH2/SH3 adapter protein dreadlocks",
                "gene_name": "dock",
                "tax_name": "Fruit fly"
            }
        ],
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                "name": "Drosophila melanogaster",
                "taxid": 7227,
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9VI13",
                        "url": "https://www.uniprot.org/uniprotkb/Q9VI13"
                    }
                ],
                "common_name": "Fruit fly",
                "glygen_name": "Fruit fly",
                "reference_species": "Drosophila melanogaster [7227]"
            }
        ],
        "mutagenesis": [
            {
                "start_pos": 113,
                "end_pos": 704,
                "sequence_org": "RLLMNSNISKQEQKKNPQAVLDVLKWFDNTTKQRPSSKYMTNAITTHSGSSLSRVSSSSPSSTPTDSELHGSNSGGNLIGVQLGSMTLGPNANNVAVAGQILGNHYQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFVGHTVSSSTSQHSSANEDDMLGPQHPQQQPPPPPVASRPERTKSIYTRPIEDLQPAIIPMPVAPATTPATPLQNHRTPGGISAPAASPMMHNNATTTLDKNKNNANLYTPEPTVAQVSAGGPSSQVAGNQIAVPQAAVAPAATPNTRAANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLIMAAKEATKGN",
                "sequence_mut": "",
                "comment": "In Pak6; pharate adult lethal with some adult escapers that are uncoordinated and have crumpled wings.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9VI13",
                        "url": "https://www.uniprot.org/uniprotkb/Q9VI13"
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                        "id": "10399914",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/10399914"
                    }
                ],
                "uniprot_canonical_ac": "Q9VI13-1"
            },
            {
                "start_pos": 14,
                "end_pos": 14,
                "sequence_org": "R",
                "sequence_mut": "M",
                "comment": "Disruption of interaction with dock/dreadlocks.",
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                    {
                        "database": "UniProtKB",
                        "id": "Q9VI13",
                        "url": "https://www.uniprot.org/uniprotkb/Q9VI13"
                    },
                    {
                        "database": "PubMed",
                        "id": "10399914",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/10399914"
                    }
                ],
                "uniprot_canonical_ac": "Q9VI13-1"
            },
            {
                "start_pos": 227,
                "end_pos": 704,
                "sequence_org": "QQQQPLLHQNHNQHHMGISQSHSYNFVGHTVSSSTSQHSSANEDDMLGPQHPQQQPPPPPVASRPERTKSIYTRPIEDLQPAIIPMPVAPATTPATPLQNHRTPGGISAPAASPMMHNNATTTLDKNKNNANLYTPEPTVAQVSAGGPSSQVAGNQIAVPQAAVAPAATPNTRAANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLIMAAKEATKGN",
                "sequence_mut": "",
                "comment": "In Pak11; pharate adult lethal with some adult escapers that are uncoordinated and have crumpled wings.",
                "evidence": [
                    {
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                        "id": "Q9VI13",
                        "url": "https://www.uniprot.org/uniprotkb/Q9VI13"
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                        "id": "10399914",
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            {
                "start_pos": 459,
                "end_pos": 459,
                "sequence_org": "K",
                "sequence_mut": "A",
                "comment": "Fails to rescue mutant phenotype, probably due to disruption of kinase activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9VI13",
                        "url": "https://www.uniprot.org/uniprotkb/Q9VI13"
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                        "id": "10399914",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/10399914"
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                ],
                "uniprot_canonical_ac": "Q9VI13-1"
            },
            {
                "start_pos": 553,
                "end_pos": 553,
                "sequence_org": "D",
                "sequence_mut": "N",
                "comment": "In Pak5; pharate adult lethal with some adult escapers that are uncoordinated and have crumpled wings, probably due to disruption of kinase activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9VI13",
                        "url": "https://www.uniprot.org/uniprotkb/Q9VI13"
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                        "id": "10399914",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/10399914"
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            },
            {
                "start_pos": 569,
                "end_pos": 569,
                "sequence_org": "G",
                "sequence_mut": "D",
                "comment": "In Pak3; pharate adult lethal with some adult escapers that are uncoordinated and have crumpled wings, probably due to disruption of kinase activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9VI13",
                        "url": "https://www.uniprot.org/uniprotkb/Q9VI13"
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                        "id": "10399914",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/10399914"
                    }
                ],
                "uniprot_canonical_ac": "Q9VI13-1"
            },
            {
                "start_pos": 91,
                "end_pos": 94,
                "sequence_org": "HTVH",
                "sequence_mut": "LTVL",
                "comment": "Fails to rescue mutant phenotype, probably due to disruption of Cdc42 interaction.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9VI13",
                        "url": "https://www.uniprot.org/uniprotkb/Q9VI13"
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                    {
                        "database": "PubMed",
                        "id": "10399914",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/10399914"
                    }
                ],
                "uniprot_canonical_ac": "Q9VI13-1"
            },
            {
                "start_pos": 9,
                "end_pos": 9,
                "sequence_org": "P",
                "sequence_mut": "L",
                "comment": "Disruption of interaction with dock/dreadlocks. In Pak4; pharate adult lethal with some adult escapers that are uncoordinated and have crumpled wings.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9VI13",
                        "url": "https://www.uniprot.org/uniprotkb/Q9VI13"
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            },
            {
                "start_pos": 186,
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                "sequence_org": "W",
                "sequence_mut": "K",
                "comment": "Probably disrupts the binding pocket of SH3 domain 1. No effect on interaction with Pak. Unable to rescue R cell projection phenotype in loss of function mutants; when associated with Q-336.",
                "evidence": [
                    {
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                        "id": "Q8IPW2",
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                    {
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                        "id": "9482841",
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                    }
                ],
                "uniprot_canonical_ac": "Q8IPW2-2"
            },
            {
                "start_pos": 289,
                "end_pos": 289,
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                "sequence_mut": "K",
                "comment": "Probably disrupts the binding pocket of SH3 domain 2. Disrupts interaction with Pak. Unable to rescue R cell projection phenotype in loss of function mutants.",
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                "start_pos": 363,
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                "sequence_org": "W",
                "sequence_mut": "K",
                "comment": "Probably disrupts the binding pocket of SH3 domain 3. No effect on interaction with Pak. Unable to rescue R cell projection phenotype in loss of function mutants; when associated with Q-336.",
                "evidence": [
                    {
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                        "id": "Q8IPW2",
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    },
    {
        "title": "Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity.",
        "journal": "Cell",
        "date": "2000",
        "authors": "Schmucker D, Clemens J C, Shu H, Worby C A, Xiao J, Muda M, Dixon J E, Zipursky S L",
        "reference": {
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                "protein_name": "Serine/threonine-protein kinase Pak",
                "gene_name": "Pak",
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                "uniprot_canonical_ac": "Q0E9H9-1",
                "protein_name": "Cell adhesion molecule Dscam1",
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                "tax_name": "Fruit fly"
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                "protein_name": "SH2/SH3 adapter protein dreadlocks",
                "gene_name": "dock",
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            }
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                "taxid": 7227,
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                        "id": "Q9VI13",
                        "url": "https://www.uniprot.org/uniprotkb/Q9VI13"
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                ],
                "common_name": "Fruit fly",
                "glygen_name": "Fruit fly",
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            }
        ],
        "record_id": "pubmed.10892653",
        "abstract": "",
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