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                "start_pos": 1256,
                "end_pos": 1256,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Significantly reduced interaction with PEAK1; when associated with F-1173 and F-1206.",
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                    {
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                        "url": "https://www.uniprot.org/uniprotkb/Q68CZ2"
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                "start_pos": 1188,
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                "sequence_mut": "F",
                "comment": "Fails to bind SHC1. Reduced recruitment of SHC1 to focal adhesions. Slightly reduces interaction with GRB2. Does not affect interaction with RASAL2. Does not affect association with integrin ITGB1.",
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                    {
                        "database": "UniProtKB",
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                    {
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                "start_pos": 635,
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                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Impairs interaction with tensin TNS3 and association with integrin ITGB1. 50% reduction in interaction with GRB2. No effect on interaction with unphosphorylated SHC1 but reduces interaction with tyrosine-phosphorylated SHC1. Reduces focal adhesion localization. Reduces cell migration.",
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                "sequence_org": "Y",
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                "comment": "No effect on cell surface location but impairs interaction with TNS3 and PEAK1.",
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                        "database": "UniProtKB",
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                "sequence_org": "Y",
                "sequence_mut": "A",
                "comment": "No effect on cell surface location but impairs interaction with TNS3 and PEAK1. Strongly reduces ITGB1BP1 binding; when associated with A-792.",
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                "sequence_org": "Y",
                "sequence_mut": "A",
                "comment": "No effect on cell surface location but impairs interaction with TNS3 and PEAK1.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P05106",
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                    {
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    {
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    {
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